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General Information
Symbol
Dmel\sqh
Species
D. melanogaster
Name
spaghetti squash
Annotation Symbol
CG3595
Feature Type
FlyBase ID
FBgn0003514
Gene Model Status
Stock Availability
Gene Snapshot
spaghetti squash (sqh) encodes the regulatory light chain of the nonmuscle type 2 myosin. Its phosphorylation through the Rho-Rho Kinase pathway is predicted to activate myosin motor activity. The product of sqh and myosin function in cellular processes such as cytokinesis, and also contribute to tissue morphogenesis. [Date last reviewed: 2019-03-14]
Also Known As
MRLC, myosin II, myosin regulatory light chain, MyoII, RLC
Key Links
Genomic Location
Cytogenetic map
Sequence location
X:6,223,061..6,225,140 [-]
Recombination map
1-16
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
-
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
Predictions / Assertions
Summaries
Gene Group (FlyBase)
MYOSIN LIGHT CHAINS -
Myosin light chains (MLC) bind myosin heavy chains via an IQ motif in the neck region. They are involved in myosin motor-based movement along actin filaments, regulating ATP hydrolysis or providing a structural function. The calmodulins included in this group have been shown to act as MLCs. (Adapted from FBrf0134714).
Protein Function (UniProtKB)
Required for cytokinesis, could regulate contractile ring function.
(UniProt, P40423)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
sqh: spaghetti squash (D. P. Kiehart)
The structural gene for cytoplasmic myosin light chain (Chang et al.) In the homozygous sqh1 mutant, the normally diploid larval tissues (e.g., brain, imaginal disc, and gonad) possess numerous polyploid cells resulting from an intermittent failure of cytokinesis. Repeated rounds of apparently normal mitosis without cytokinesis produce cells containing hundreds of chromosomes. The mutant is a late larval-early pupal lethal with an extended larval period (10-14 days), during which the brain grows to enormous size. Imaginal discs are small and poorly formed (Karess).
Summary (Interactive Fly)
EF-hand, calcium binding motif protein that serves as the regulatory light chain of nonmuscle myosin II
Gene Model and Products
Number of Transcripts
5
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\sqh or the JBrowse view of Dmel\sqh for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.49
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.55
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0070877
1117
174
FBtr0339502
1093
174
FBtr0339503
1403
174
FBtr0339504
1097
174
FBtr0345294
1024
174
Additional Transcript Data and Comments
Reported size (kB)
1.2 (northern blot)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0070842
20.0
174
4.40
FBpp0308586
20.0
174
4.40
FBpp0308587
20.0
174
4.40
FBpp0308588
20.0
174
4.40
FBpp0311461
20.0
174
4.40
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

174 aa isoforms: sqh-PA, sqh-PB, sqh-PC, sqh-PD, sqh-PE
Additional Polypeptide Data and Comments
Reported size (kDa)
174 (aa); 20 (kD)
Comments
External Data
Subunit Structure (UniProtKB)
Myosin is a hexamer of 2 heavy chains and 4 light chains.
(UniProt, P40423)
Post Translational Modification
Phosphorylation plays a central role in myosin regulation.
(UniProt, P40423)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\sqh using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (38 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
inferred from electronic annotation with InterPro:IPR002048
(assigned by InterPro )
Biological Process (19 terms)
Terms Based on Experimental Evidence (16 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from direct assay
inferred from mutant phenotype
inferred from mutant phenotype
inferred from expression pattern
inferred from mutant phenotype
inferred from mutant phenotype
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
Cellular Component (17 terms)
Terms Based on Experimental Evidence (17 terms)
CV Term
Evidence
References
colocalizes_with adherens junction
inferred from direct assay
inferred from direct assay
inferred from direct assay
inferred from direct assay
colocalizes_with cell-cell junction
inferred from direct assay
inferred from direct assay
inferred from direct assay
inferred from physical interaction with FLYBASE:zip; FB:FBgn0265434
inferred from direct assay
inferred from high throughput direct assay
inferred from direct assay
inferred from direct assay
Terms Based on Predictions or Assertions (0 terms)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
organism

Comment: maternally deposited

Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
epithelial furrow

Comment: monophosphorylated and total sqh

proctodeum

Comment: diphosphorylated sqh

epithelial cell

Comment: monophosphorylated and total sqh

embryonic/larval salivary gland

Comment: monophosphorylated and total sqh

embryonic/larval pharynx

Comment: monophosphorylated and total sqh

embryonic/larval foregut

Comment: monophosphorylated and total sqh

embryonic/larval hindgut

Comment: monophosphorylated and total sqh

embryonic/larval epidermis

Comment: monophosphorylated and total sqh

ventral nerve cord

Comment: monophosphorylated and total sqh

dorsal pouch

Comment: diphosphorylated sqh

mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
The distribution of monophosphorylated squ (designated Sqh1P) and diphosphorylated sqh (designated Sqh2P) were compared. In embryos, Sqh1P is fairly ubiquitously expressed and has a pattern that is indistinguishable from total sqh and zip. In cellularizing embryos, staining is observed at the leading edge of cleavage furrows. In gastrulating embryos, it is observed in the cytoplasm with enrichment near the basal membrane in dorsal and lateral cells with more apical enrichment in gastrulating cells. In stage 12 embryos, epithelial cells appear to be outlined. In the salivary gland Sqh1P is localized apically. In stage 14 embryos, high levels of Sqh1P are seen in the ventral nerve cord relative to the rest of the embryo and expression is also strong in the pharynx, foregut, hindgut and epidermis. Sqh2P is expressed in the invaginating stomodeum and proctodeum in stage 10 embryos. At stage 11, it is strongly expressed in the tracheal placodes and can still be observed in the proctodeal opening. In stage 12, Sqh2P is expressed in the invaginating tracheal metameres. At stage 13, it is expressed in the tracheal system as adjacent metemeres are fusing. It is also expressed strongly in epidermal cells that line the segmental boundary but not in intersegmental epidermal cells. Strong localization is seen at stage 14 in the dorsal pouch.
Marker for
 
Subcellular Localization
CV Term
Evidence
References
colocalizes_with adherens junction
inferred from direct assay
inferred from direct assay
inferred from direct assay
inferred from direct assay
colocalizes_with cell-cell junction
inferred from direct assay
inferred from direct assay
inferred from direct assay
inferred from physical interaction with FLYBASE:zip; FB:FBgn0265434
inferred from direct assay
inferred from high throughput direct assay
inferred from direct assay
inferred from direct assay
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\sqh in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 10 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 53 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of sqh
Transgenic constructs containing regulatory region of sqh
Deletions and Duplications ( 4 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (8)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
13 of 15
Yes
Yes
 
12 of 15
No
Yes
 
8 of 15
No
Yes
 
4 of 15
No
No
3 of 15
No
No
3 of 15
No
No
2 of 15
No
No
2 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (7)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
14 of 15
Yes
Yes
13 of 15
No
Yes
13 of 15
No
Yes
3 of 15
No
No
3 of 15
No
No
3 of 15
No
No
2 of 15
No
No
Rattus norvegicus (Norway rat) (7)
13 of 13
Yes
Yes
11 of 13
No
Yes
10 of 13
No
Yes
3 of 13
No
No
3 of 13
No
No
1 of 13
No
Yes
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (6)
12 of 12
Yes
Yes
6 of 12
No
Yes
2 of 12
No
No
2 of 12
No
No
2 of 12
No
No
1 of 12
No
No
Danio rerio (Zebrafish) (11)
14 of 15
Yes
Yes
12 of 15
No
Yes
11 of 15
No
Yes
8 of 15
No
Yes
3 of 15
No
No
3 of 15
No
No
3 of 15
No
No
3 of 15
No
No
3 of 15
No
No
3 of 15
No
No
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (3)
13 of 15
Yes
Yes
4 of 15
No
No
3 of 15
No
No
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (1)
2 of 15
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (1)
6 of 12
Yes
Yes
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG09190HCB )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150C61 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Anopheles gambiae
Malaria mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0FQK )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0G96 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Ixodes scapularis
Black-legged tick
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0QF6 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (2)
5 of 10
3 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 2 )
    Allele
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser

    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement

    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    suppressible
    External Data
    Subunit Structure (UniProtKB)
    Myosin is a hexamer of 2 heavy chains and 4 light chains.
    (UniProt, P40423 )
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    X
    Recombination map
    1-16
    Cytogenetic map
    Sequence location
    X:6,223,061..6,225,140 [-]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    5E1-5E1
    Limits computationally determined from genome sequence between P{EP}EP1457EP1457&P{EP}CG5928EP1083 and P{EP}EP1311&P{EP}EP1384
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    5D5-5D6
    (determined by in situ hybridisation)
    Experimentally Determined Recombination Data
    Location
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (21)
    Genomic Clones (13)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (227)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequences
    BDGP DGC clones
    Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      Other clones
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      Antibody Information
      Laboratory Generated Antibodies
      Commercially Available Antibodies
       
      Cell Signaling Technology - Commercial vendor for primary antibodies and antibody conjugates.
      Other Information
      Relationship to Other Genes
      Source for database identify of
      Source for database merge of
      Additional comments
      Other Comments
      Inhibition of sqh by injection of Y-27632 in embryos results in cuticle shaping defects.
      dsRNA directed against this gene causes defects in cytokinesis when tested in an RNAi screen in S2 cells.
      Pharmacological and genetic analyses show that sqh is not necessary for the first phase of cellularization in embryos, but is needed for basal closure of the cellularization furrows.
      Reduction in the gene dosage of sqh is not sufficient to elicit the malformed phenotype in combination with zip alleles.
      Mutant analysis indicates that phosphorylation sites of sqh protein are essential for its function in vivo.
      sqh mutant phenotypes are chiefly caused by sequestration of myosin into inactive aggregates.
      Phosphorylation at the putative target of myosin light chain kinase is essential for the in vivo activity of the sqh product. Altered sqh lacking all three putative targets of protein kinase C and p34/cdc2 kinase still functions adequately during cytokinesis, but not wing formation.
      Supply of sqh by the maternal germ line is required normal embryonic development, specifically for both dumping, rapid phase of cytoplasmic transport, and axial expansion of the cloud of cleavage nuclei during the first 6 cycles of nuclear division.
      A weak allele is 100% lethal due to failure of larval cytokinesis, insertions of a heat shock inducible sqh cDNA rescue larvae to adulthood.
      sqh encodes the regulatory light chain of the nonmuscle myosin.
      sqh is essential for successful cytokinesis.
      The structural gene for cytoplasmic myosin light chain (Chang, Edwards and Kiehart, Karess, Kulkarni and Aguilera, 1991).
      Origin and Etymology
      Discoverer
      Etymology
      Identification
      External Crossreferences and Linkouts ( 177 )
      Sequence Crossreferences
      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
      UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
      Other crossreferences
      BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
      Flygut - An atlas of the Drosophila adult midgut
      Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
      InterPro - A database of protein families, domains and functional sites
      KEGG Genes - Molecular building blocks of life in the genomic space.
      modMine - A data warehouse for the modENCODE project
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      Cell Signaling Technology - Commercial vendor for primary antibodies and antibody conjugates.
      Cell Signaling Technology - Commercial vendor for primary antibodies and antibody conjugates.
      DroID - A comprehensive database of gene and protein interactions.
      DRSC - Results frm RNAi screens
      FLIGHT - Cell culture data for RNAi and other high-throughput technologies
      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
      FlyMine - An integrated database for Drosophila genomics
      Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
      MIST (genetic) - An integrated Molecular Interaction Database
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Synonyms and Secondary IDs (66)
      Reported As
      Symbol Synonym
      Sqh
      (D'Angelo et al., 2019, Das Gupta and Narasimha, 2019, Finegan et al., 2019, Qin et al., 2018, Segal et al., 2018, Tsoumpekos et al., 2018, Xu et al., 2018, Chan et al., 2017, Ly et al., 2017, Tran and Ten Hagen, 2017, Bielmeier et al., 2016, Pasakarnis et al., 2016, Valencia-Expósito et al., 2016, Vasquez et al., 2016, Vega-Macaya et al., 2016, Lim et al., 2015, Lim et al., 2015, Liu et al., 2015, Rodrigues et al., 2015, Rosa et al., 2015, Spencer et al., 2015, Carvalho et al., 2014, He et al., 2014, Kitazawa et al., 2014, Sechi et al., 2014, Yashiro et al., 2014, Antunes et al., 2013, Fuse et al., 2013, Herszterg et al., 2013, Jauffred et al., 2013, Levayer and Lecuit, 2013, Manning et al., 2013, Mao et al., 2013, Morais-de-Sá and Sunkel, 2013, Osterfield et al., 2013, Pronovost et al., 2013, Belloni et al., 2012, Giansanti and Fuller, 2012, Giansanti et al., 2012, Sen et al., 2012, Wainman et al., 2012, Azevedo et al., 2011, Ben El Kadhi et al., 2011, Cheng et al., 2011, Hatan et al., 2011, Levayer et al., 2011, Szafer-Glusman et al., 2011, He et al., 2010, Coumailleau et al., 2009, Grusche et al., 2009, McCleland et al., 2009, Mirouse et al., 2009, Robinett et al., 2009, Carrasco-Rando and Ruiz-Gómez, 2008, Carreno et al., 2008, Caussinus et al., 2008, Homem and Peifer, 2008, Mulinari et al., 2008, Pope and Harris, 2008, Roy et al., 2008, Simone and DiNardo, 2008, Szafer-Glusman et al., 2008, Witzberger et al., 2008, Wong et al., 2008, Chandraratna et al., 2007, Frei et al., 2007, Wong et al., 2007, Blankenship et al., 2006, Pearson et al., 2006, Winter et al., 2001)
      sqh
      (Chen et al., 2019, Johnson and Toettcher, 2019, Moreno et al., 2019, Proag et al., 2019, Córdoba and Estella, 2018, Dunn et al., 2018, Franz et al., 2018, Ikawa and Sugimura, 2018, Inaki et al., 2018, Kale et al., 2018, Lebreton et al., 2018, Ogura et al., 2018, Richardson and Portela, 2018, Sharma et al., 2018, Sui et al., 2018, Toret et al., 2018, Tsoumpekos et al., 2018, Tsuboi et al., 2018, Wang et al., 2018, An et al., 2017, Bianchi et al., 2017, Chung et al., 2017, Clément et al., 2017, Curran et al., 2017, Harmansa et al., 2017, Hayes and Solon, 2017, Jewett et al., 2017, Rothenbusch-Fender et al., 2017, Simões et al., 2017, Sun et al., 2017, Tsankova et al., 2017, Zihni et al., 2017, Aigouy and Le Bivic, 2016, Chan, 2016.3.5, Czerniak et al., 2016, Duque and Gorfinkiel, 2016, Hara et al., 2016, Jurado et al., 2016, Kerridge et al., 2016, Ng et al., 2016, Sarov et al., 2016, Tetley et al., 2016, Weavers et al., 2016, Weng and Wieschaus, 2016, Álvarez-Fernández et al., 2015, Chan, 2015.10.20, Hosono et al., 2015, Hunter et al., 2015, Levayer et al., 2015, Munjal et al., 2015, Sato et al., 2015, Booth et al., 2014, Cook, 2014.8.25, Ferreira et al., 2014, Kasza et al., 2014, Merlo et al., 2014, Muliyil and Narasimha, 2014, Nie et al., 2014, Rauskolb et al., 2014, Razzell et al., 2014, Reversi et al., 2014, Singari et al., 2014, Taniguchi et al., 2014, Vasquez et al., 2014, Zulueta-Coarasa et al., 2014, Aldaz et al., 2013, Fernandez-Gonzalez and Zallen, 2013, Khoo et al., 2013, Külshammer and Uhlirova, 2013, Kwon et al., 2013, Moon and Matsuzaki, 2013, Saravanan et al., 2013, Thomae et al., 2013, Yamamoto et al., 2013, Abreu-Blanco et al., 2012, Andersen et al., 2012, Bosveld et al., 2012, Crest et al., 2012, Duboff et al., 2012, Foronda et al., 2012, Förster and Luschnig, 2012, Gault et al., 2012, Giansanti et al., 2012, Ishihara and Sugimura, 2012, Kaushik et al., 2012, Lesch and Page, 2012, Roper, 2012, Abreu-Blanco et al., 2011, Bassi et al., 2011, Becam et al., 2011, Caussinus et al., 2011, Fernandez-Gonzalez and Zallen, 2011, Friedman et al., 2011, Geiger et al., 2011, Hampoelz et al., 2011, Jiang et al., 2011, Meghana et al., 2011, Monier et al., 2011, Muyskens and Guillemin, 2011, Neumüller et al., 2011, Sawyer et al., 2011, Sommi et al., 2011, Sun et al., 2011, Szafer-Glusman et al., 2011, Tang et al., 2011, Vlachos and Harden, 2011, Zhang and Ward, 2011, Aldaz et al., 2010, Baer et al., 2010, Blanchard et al., 2010, Bland et al., 2010, David et al., 2010, Djiane and Mlodzik, 2010, Franke et al., 2010, Goldbach et al., 2010, Kwon et al., 2010, Martin et al., 2010, Montembault et al., 2010, Neubueser and Hipfner, 2010, Okumura et al., 2010, Popodi et al., 2010-, Rauzi et al., 2010, Sánchez-Soriano et al., 2010, Simões et al., 2010, Simone and DiNardo, 2010, Venken et al., 2010, Wang and Ward, 2010, Zimmerman et al., 2010, Atallah et al., 2009, Atwood and Prehoda, 2009, Ayers et al., 2009, Bertet et al., 2009, Bischoff and Cseresnyés, 2009, Chung et al., 2009, Desai et al., 2009, Fernandez-Gonzalez et al., 2009, Mirouse et al., 2009, Nicolas et al., 2009, Polevoy et al., 2009, Venken et al., 2009, Venken et al., 2009, Warner and Longmore, 2009, Widmann and Dahmann, 2009, Alves-Silva et al., 2008, D'Avino et al., 2008, Franciscovich et al., 2008, Okumura et al., 2008, Todi et al., 2008, Chung et al., 2007, Corrigall et al., 2007, Dorsten et al., 2007, Dyer et al., 2007, Escudero et al., 2007, Kirchner et al., 2007, Kolesnikov and Beckendorf, 2007, Lai et al., 2007, Mitonaka et al., 2007, Ninov et al., 2007, Song et al., 2007, Wang and Riechmann, 2007, Borghese et al., 2006, Brodu and Casanova, 2006, Franke et al., 2006, Hickson et al., 2006, Montana and Littleton, 2006, Simoes et al., 2006, Verdier et al., 2006, Walters et al., 2006, Haddrill et al., 2005, Padash Barmchi et al., 2005, Papoulas et al., 2005, Royou et al., 2004, Vereshchagina et al., 2004, Winter et al., 2001)
      Name Synonyms
      MyoII regulatory light chain
      Myosin II regulatory light chain
      Myosin II regulatory subunit
      Myosin Regulatory Light Chain
      Myosin regulatory light chain
      Myosin-II light chain
      light chain of nonmuscle Myosin II
      myo-II regulatory light chain
      myosin II regulatory light chain
      myosin-II light chain
      myosinII
      non-muscle Myosin II
      non-muscle myosin II regulatory light chain
      non-muscle myosin-II
      nonmuscle myosin II regulatory light chain
      phospho-Myosin light chain 2
      regulatory light chain
      regulatory light chain of Myosin II
      regulatory light chain of myosin
      regulatory light chain of nonmuscle myosin II
      regulatory light chain of nonmuscle myosin-II
      regulatory myosin light chain
      type II myosin regulatory light chain
      Secondary FlyBase IDs
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        References (549)