FlyBase Gene Report: Dmel\sta

General Information

Symbol

Dmel\sta

Species

D. melanogaster

Name

stubarista

Annotation Symbol

CG14792

Feature Type

protein_coding_gene

FlyBase ID

FBgn0003517

Gene Model Status

Current

Stock Availability

13 publicly available

Gene Snapshot

Contributions welcome

Other Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Red Book
Interactive Fly

Also Known As

EG:80H7.6 , l(1)G0130, RpSA, l(1)G0448, P40

Key Links

Genomic Location

Cytogenetic map

2B1-2B1

Sequence location

X:1,481,797..1,483,413 [-]

Recombination map

1-0.2

RefSeq locus

NC_004354 REGION:1481797..1483413

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (8 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables ribosome binding

inferred from physical interaction with UniProtKB:O76927

(Torok et al., 1999)

enables structural constituent of ribosome

inferred from high throughput direct assay

(Alonso and Santaren, 2006)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables structural constituent of ribosome

inferred from biological aspect of ancestor with PANTHER:PTN000160708

(assigned by GO_Central )

(Gaudet et al., 2011)

traceable author statement

(Marygold et al., 2007)

Biological Process (3 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in cytoplasmic translation

inferred from biological aspect of ancestor with PANTHER:PTN000160709

(assigned by GO_Central )

(Gaudet et al., 2011)

traceable author statement

(Marygold et al., 2007)

inferred by curator from GO:0022626

(Alonso and Santaren, 2006)

involved_in ribosomal small subunit assembly

inferred from biological aspect of ancestor with PANTHER:PTN000160708

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in translation

inferred from biological aspect of ancestor with PANTHER:PTN000160708

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

located_in cytosolic ribosome

inferred from high throughput direct assay

(Alonso and Santaren, 2006)

located_in ribosome

inferred from direct assay

(Torok et al., 1999)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

part_of cytosolic small ribosomal subunit

inferred from biological aspect of ancestor with PANTHER:PTN000160708

(assigned by GO_Central )

(Gaudet et al., 2011)

traceable author statement

(Marygold et al., 2007)

Gene Group (FlyBase)

CYTOPLASMIC SMALL RIBOSOMAL PROTEINS

Protein Family (UniProt)

Belongs to the universal ribosomal protein uS2 family. (P38979)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

CYTOPLASMIC SMALL RIBOSOMAL PROTEINS -: Cytoplasmic ribosomes are found on the endoplasmic reticulum and in the cytoplasm. They translate all mRNAs produced from nuclear genes and perform the majority of cellular protein synthesis. Ribosomes are formed by two ribonucleoprotein subunits, large and small. The principle function of the small subunit is to bind mRNA. (Adapted from FBrf0205398)

Protein Function (UniProtKB)

Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Required during oogenesis and imaginal development.

(UniProt, P38979)

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

sta: stubarista

sta: stubarista

From Bridges and Brehme, 1944, Carnegie Inst. Washington Publ. No. 552: 180.

Third joints of antennae short, blunt, free of hairs, and yellowish. Aristae bases thickened, axes sometimes short, and branches irregular. All bristles and hairs extremely short and sparse. Eyes rotated on head slightly so that the long axis is vertical. Homozygous sta1 females unable to oviposit; stage 14 oocytes appear normal (King, 1970, Ovarian Development in Drosophila, Academic Press, New York). Lethal allele (sta2) in combination with variegating translocation (T(1;2)dorvar7) produces incised wing margins, small rough eyes with missing facets, and missing head macrochaetae [Demakova and Belyaeva, 1988, DIS 67: 21 (fig.)]. RK2A.

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\sta for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

snoRNA:M inserted in intron.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.49

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

sta-RA

FBtr0070289

NM_057402

1109

270

sta-RB

FBtr0070290

NM_166889

1083

270

sta-RE

FBtr0339593

NM_166890

1035

270

sta-RF

FBtr0339594

NM_001297856

1088

270

Additional Transcript Data and Comments

Reported size (kB)

1.0 (northern blot)

(Melnick et al., 1993)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

sta-PA

FBpp0070277

30.2

270

4.50

NP_476750

AAF45638

sta-PB

FBpp0070278

30.2

270

4.50

NP_726744

AAN09049

sta-PE

FBpp0308665

30.2

270

4.50

NP_726745

AAN09050

sta-PF

FBpp0308666

30.2

270

4.50

NP_001284785

AHN59256

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

270 aa isoforms: sta-PA, sta-PB, sta-PE, sta-PF

Additional Polypeptide Data and Comments

Reported size (kDa)

270 (aa)

(Melnick et al., 1993)

Comments

External Data

Subunit Structure (UniProtKB)

Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with oho23B/rpS21.

(UniProt, P38979)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

P38979

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\sta using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

sta_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

expression microarray

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage | female

(Arbeitman et al., 2004)

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 13 -- 16

embryonic/larval midgut

(Fisher et al., 2012)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage | female

(Arbeitman et al., 2004)

Additional Descriptive Data

sta is expressed maternally and throughout development. It is ubiquitously expressed in embryos.

(Melnick et al., 1993)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

day 5 of adulthood & male -- day 7 of adulthood & male

spermatozoon

(Wasbrough et al., 2010)

day 7 of adulthood -- day 49 of adulthood

adult heart

(Cammarato et al., 2011)

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

sta was found to be equally distributed among ribosomal particles, including polysomes, monomeric 80S ribosomes, and native ribosomal subunits.

(Torok et al., 1999)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in cytosolic ribosome

inferred from high throughput direct assay

(Alonso and Santaren, 2006)

located_in ribosome

inferred from direct assay

(Torok et al., 1999)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\sta in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\sta

View exonic expression by tissue for Dmel\sta

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0003517

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0003517

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG14792-RA

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG14792

Flygut - An atlas of the Drosophila adult midgut

FBgn0003517

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\sta

Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 25 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 10 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of sta

Transgenic constructs containing regulatory region of sta

Deletions and Duplications ( 43 )

Disrupted in

Df(1)A94

(Marygold et al., 2007, Craymer and Roy, 1980)

Df(1)br²⁵

(Mazina et al., 1991, Belyaeva et al., 1987, Belyaeva et al., 1982)

Df(1)br-rv1

(Belyaeva et al., 1987)

Df(1)BSC719

(Christensen et al., 2008.12.28)

Df(1)Exel8196

(Marygold et al., 2007, Ryder, 2004.4.26)

Df(1)H27.2

(Prudhommeau and Proust, 1990)

Df(1)JTΔ1

(Mazina et al., 1991)

Df(1)RA19

(Aizenzon and Belyaeva, 1982, Belyaeva et al., 1982)

Df(1)rush⁴

(Gailite et al., 2012)

Df(1)S39

(Marygold et al., 2007, Belyaeva et al., 1987, Aizenzon and Belyaeva, 1982, Craymer and Roy, 1980)

Df(1)St469

(Belyaeva et al., 1987)

Df(1)St490

(Mazina et al., 1991, Belyaeva et al., 1987)

Df(1)sta

(Melnick et al., 1993, Pokholkova et al., 1993, Mazina et al., 1991, Belyaeva et al., 1987, Aizenzon and Belyaeva, 1982, Belyaeva et al., 1982)

In(1)br¹⁰³

(Belyaeva et al., 1987)

T(1;3)sc^J4

(Marygold et al., 2007)

Tp(1;3)sta

(Mazina et al., 1991, Rayle and Hoar, 1969)

Not duplicated in

Dp(1;3)w^vco

(Rayle and Hoar, 1969)

Dp(1;f)3

(Rayle and Hoar, 1969)

Dp(1;f)18

(Rayle and Hoar, 1969)

Dp(1;f)101

(Melnick et al., 1993, Rayle and Hoar, 1969)

Dp(1;f)112

(Belyaeva et al., 1982)

Dp(1;Y)2E-C

(Rayle and Hoar, 1969)

Dp(1;Y)Sz280

(Belyaeva et al., 1987)

Dp(1;Y)y⁺

(Proust et al., 1992)

Not disrupted in

Df(1)At127

(Aizenzon and Belyaeva, 1982, Belyaeva et al., 1982)

Df(1)P154

(Mazina et al., 1991)

Df(1)St472

(Mazina et al., 1991, Belyaeva et al., 1987, Aizenzon and Belyaeva, 1982)

Df(1)svr

(California Institute of Technology, 1940)

T(1;3)JTΔ3

(Mazina et al., 1991)

Ts(1Lt;YLt)G20

(Belyaeva et al., 1987)

Ts(1Lt;YSt)B131

(Belyaeva et al., 1987)

Ts(1Rt;2Rt)Bld

(California Institute of Technology, 1940)

Partially duplicated in

Dp(1;Y)y^59b

(Belyaeva et al., 1982)

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal

lethal, with Scer\GAL4^pnr-MD237

sta^GD8443

lethal | recessive

lethal - all die before end of larval stage

lethal - all die before end of larval stage | recessive

sta²

lethal - all die before end of pupal stage, with Scer\GAL4^pnr-MD237

sta^GD16287

lethal - all die during larval stage, with Scer\GAL4^Mef2.PR

sta^GD8443

partially lethal, with Scer\GAL4^tin.CΔ4

sta^GD8443

viable

sta¹

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

sta^GD8443

Sterility

Allele

female sterile

sta¹

Other Phenotypes

Allele

developmental rate defective | larval stage

sta²

size defective | larval stage

sta²

some die during larval stage

some die during larval stage | recessive

sta²

some die during pupal stage, with Scer\GAL4^pnr-MD237

sta^GD16287

visible

wild-type

sta^+t4.4

Phenotype manifest in

Allele

antenna

sta¹

arista

sta¹

embryonic/larval lymph gland

sta²

embryonic/larval somatic muscle, with Scer\GAL4^Mef2.PR

sta^GD8443

imaginal disc | larval stage

sta²

macrochaeta

sta¹

primary lobe of embryonic/larval lymph gland

sta²

sarcomere, with Scer\GAL4^Mef2.PR

sta^GD8443

Z disc, with Scer\GAL4^Mef2.PR

sta^GD8443

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (4)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\RPSA

13 of 15

Yes

Hsap\RPSAP58

2 of 15

Yes

Hsap\MRPS2

1 of 15

Hsap\SMKR1

1 of 15

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (2)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Rpsa

12 of 15

Yes

Mmus\Mrps2

1 of 15

Rattus norvegicus (Norway rat) (2)

Rnor\Rpsa

12 of 13

Yes

Rnor\Mrps2

1 of 13

Xenopus tropicalis (Western clawed frog) (2)

Xtro\rpsa

12 of 12

Yes

Xtro\mrps2

1 of 12

Danio rerio (Zebrafish) (3)

Drer\rpsa

13 of 15

Yes

Drer\zgc:110181

2 of 15

Yes

Drer\mrps2

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (1)

Cele\rps-0

12 of 15

Yes

Arabidopsis thaliana (thale-cress) (2)

Atha\P40

9 of 9

Yes

Atha\RPSAb

9 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (3)

Scer\RPS0A

13 of 15

Yes

Scer\RPS0B

13 of 15

Yes

Scer\MRP4

1 of 15

Schizosaccharomyces pombe (Fission yeast) (2)

Spom\rps001

11 of 12

Yes

Spom\rps002

11 of 12

Yes

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190DSL )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA13249

Drosophila persimilis

Dper\GL14373

Drosophila willistoni

Dwil\GK14587

Drosophila virilis

Dvir\GJ15549

Drosophila mojavensis

Dmoj\GI16040

Drosophila grimshawi

Dgri\GH17574

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091508EV )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17021702

Glossina morsitans

Tsetse fly

Gmor\GMOY000522

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_04894

Mayetiola destructor

Hessian fly

Mdes\Mdes015255

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL008083

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL013694

Anopheles darlingi

American malaria mosquito

Adar\ADAC000612

Anopheles gambiae

Malaria mosquito

Agam\RpsA

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ013899

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0928 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA007311

Danaus plexippus

Monarch butterfly

Dple\DPOGS205356-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL004550

Apis florea

Little honeybee

Aflo\2265097396

Apis mellifera

Western honey bee

Amel\GB43548

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP16487

Bombus terrestris

Buff-tailed bumblebee

Bter\15209083

Linepithema humile

Argentine ant

Lhum\LH16246

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:002a2a

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG008863

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_05782

Tribolium castaneum

Red flour beetle

Tcas\TC006550

Pediculus humanus

Human body louse

Phum\PHUM327370

Rhodnius prolixus

Kissing bug

Rpro\RPRC000499

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI004271

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI080575

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_06420

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X08YD )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR013873

Stegodyphus mimosarum

African social velvet spider

Smim\KFM74400.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM76188.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur32g02010

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_320706

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0J0Q )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Rpsa

Ciona intestinalis

Vase tunicate

Cint\LOC100184655

Gallus gallus

Domestic chicken

Ggal\RPSA

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (1)

Gene Symbol

Score

Source

Alignment

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

RPSA; ribosomal protein SA

13 of 15

150370

ASPLENIA, ISOLATED CONGENITAL; ICAS

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

sta - InR

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

sta - Myc

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

sta - Pi3K92E

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

sta - Pten

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

sta - Rack1

cosedimentation, electron microscopy

(Anger et al., 2013)

sta - RasGAP1

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

sta - RpL10

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

sta - RpL10Ab

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

sta - RpL11

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

sta - RpL12

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

sta - RpL13

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

sta - RpL13A

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

sta - RpL14

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

sta - RpL15

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

sta - RpL17

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

sta - RpL18

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

sta - RpL18A

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

sta - RpL19

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

sta - RpL21

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

sta - RpL22

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

sta - RpL23

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

sta - RpL23A

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

sta - RpL24

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

sta - RpL26

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

sta - RpL27

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

sta - RpL27A

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

sta - RpL28

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

sta - RpL29

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

sta - RpL3

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

sta - RpL30

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

sta - RpL31

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

sta - RpL32

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

sta - RpL34a

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

sta - RpL35

cosedimentation, electron microscopy

(Anger et al., 2013)

sta - RpL35A

cosedimentation, electron microscopy

(Anger et al., 2013)

sta - RpL36

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

sta - RpL36A

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

sta - RpL37A

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

sta - RpL37a

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

sta - RpL38

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

sta - RpL39

cosedimentation, electron microscopy

(Anger et al., 2013)

sta - RpL4

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

sta - RpL40

cosedimentation, electron microscopy

(Anger et al., 2013)

sta - RpL41

cosedimentation, electron microscopy

(Anger et al., 2013)

sta - RpL5

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

sta - RpL6

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

sta - RpL7

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

sta - RpL7A

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

sta - RpL8

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

sta - RpL9

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

sta - RpLP0

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

sta - RpLP1

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

sta - RpLP2

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

sta - RpS10a

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

sta - RpS11

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

sta - RpS12

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

sta - RpS13

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

sta - RpS14a

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

sta - RpS14b

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

sta - RpS15

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

sta - RpS15Aa

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

sta - RpS16

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

sta - RpS17

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

sta - RpS18

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

sta - RpS19a

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

sta - RpS2

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

sta - RpS20

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

sta - RpS21

cosedimentation, Identification by mass spectrometry, electron microscopy, pull down, autoradiography, western blot

(Anger et al., 2013, Torok et al., 1999)

sta - RpS23

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

sta - RpS24

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

sta - RpS25

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

sta - RpS26

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

sta - RpS27

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

sta - RpS27A

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

sta - RpS28b

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

sta - RpS29

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

sta - RpS3

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

sta - RpS30

cosedimentation, electron microscopy

(Anger et al., 2013)

sta - RpS3A

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

sta - RpS4

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

sta - RpS5a

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

sta - RpS6

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

sta - RpS7

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

sta - RpS8

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

sta - RpS9

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

sta - UQCR-C2

experimental knowledge based

(Guruharsha et al., 2011)

sta - cnk

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

sta - eEF2

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

sta - ksr

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

sta - sav

anti tag coimmunoprecipitation, peptide massfingerprinting

(Kwon et al., 2013)

sta - vig2

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RNA-protein

Physical Interaction

Assay

References

sta - 18SrRNA

cosedimentation, electron microscopy

(Anger et al., 2013)

sta - 28SrRNA

cosedimentation, electron microscopy

(Anger et al., 2013)

sta - 2SrRNA

cosedimentation, electron microscopy

(Anger et al., 2013)

sta - 5.8SrRNA

cosedimentation, electron microscopy

(Anger et al., 2013)

sta - 5SrRNA

cosedimentation, electron microscopy

(Anger et al., 2013)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

sta

enhanceable

RpS21

(Torok et al., 1999)

Rab5|sta

suppressible

rush

(Gailite et al., 2012)

Hrs|sta

suppressible

rush

(Gailite et al., 2012)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

car|rush

suppressible

sta

(Gailite et al., 2012)

Gdi|rush

suppressible

sta

(Gailite et al., 2012)

Hrs

enhanceable

sta

(Gailite et al., 2012)

RpS21

enhanceable

sta

(Torok et al., 1999)

enhanceable

sta

(Melnick et al., 1993)

VhaSFD|rush

suppressible

sta

(Gailite et al., 2012)

External Data

Subunit Structure (UniProtKB)

(UniProt, P38979 )

Linkouts

BioGRID - A database of protein and genetic interactions.

57663

DroID - A comprehensive database of gene and protein interactions.

FBgn0003517

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

31106

MIST (protein-protein) - An integrated Molecular Interaction Database

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

Ribosome

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-0.2

Cytogenetic map

2B1-2B1

Sequence location

X:1,481,797..1,483,413 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

2B1-2B1

Limits computationally determined from genome sequence between P{EP}futsch^EP1419 and P{EP}br^EP1515

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

2B1-2B2

(determined by in situ hybridisation) 2B1--4 (determined by in situ hybridisation)

(Peter et al., 2002)

2B1-2B4

(determined by in situ hybridisation)

(Schäfer et al., 1999.6.15, Schäfer et al., 1999.12.14)

2B1-2B2

(determined by in situ hybridisation)

(Schäfer et al., 1999.3.29)

2A3-2B2

(determined by in situ hybridisation)

(Melnick et al., 1993)

2B-2B

(determined by in situ hybridisation)

(Proust et al., 1992)

Experimentally Determined Recombination Data

Location

1-0.2

(FlyBase, 2016)

1-0.1

(Comeron et al., 2012)

Left of (cM)

(Aizenzon and Belyaeva, 1982)

Right of (cM)

Notes

Stocks and Reagents

Stocks (13)

Bloomington

4324

sta¹/FM7c

844

Tp(1;3)sta, sta¹: ss^sta/FM3

11834

P{lacW}sta^G0130 w^67c23/FM7c

76949

y¹ sc^* v¹ sev²¹; P{TKO.GS00678}attP40

78627

y¹ sc^* v¹ sev²¹; P{TOE.GS01860}attP40

Kyoto

106094

Tp(1;3)sta, sta¹: ss^sta/FM3

111791

P{lacW}sta^G0130 w^* P{neoFRT}19A/FM7c; P{ey-FLP.N}5

111945

P{lacW}sta^G0448 w^* P{neoFRT}19A/FM7c; P{ey-FLP.N}5

VDRC

v101495

P{KK108871}VIE-260B

v38823

w¹¹¹⁸; P{GD8443}v38823

v38822

w¹¹¹⁸; P{GD8443}v38822/CyO

v50129

w¹¹¹⁸; P{GD16287}v50129/TM3

More stocks available...

Genomic Clones (9)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (1293)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

RE42047

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0003517

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0003517

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

31106

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Creagh et al., 2009)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for database merge of

Source for merge of: sta l(1)G0130 l(1)G0448

(Peter et al., 2002)

Additional comments

"l(1)G0129" may affect "sta".

(Peter et al., 2002)

Other Comments

Nonsense-mediated mRNA decay (NMD) down-regulates a distinct splice isoform(s) of this gene.

(Hansen et al., 2009)

RNAi screen using dsRNA made from templates generated with primers directed against this gene results in aberrantly short, monopolar spindles when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA.

(Goshima et al., 2007)

Not a Minute gene.

(Marygold et al., 2007)

Deletions removing sta but no other cytoplasmic ribosomal protein-encoding genes do not show Minute phenotypes.

(Marygold et al., 2007)

Molecularly-defined mutations in sta do not result in Minute phenotypes.

(Marygold et al., 2007)

sta gene product is required during oogenesis and imaginal development.

(Melnick et al., 1993)

The sta locus is subject to T(1;2)dor^var7 position effect variegation.

(Demakova et al., 1988)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 63 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

31106

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

P38979

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0003517

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0003517

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

sta_1

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG14792

Flygut - An atlas of the Drosophila adult midgut

FBgn0003517

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

31106

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC006550

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG14792

modMine - A data warehouse for the modENCODE project

FBgn0003517

Linkouts

BioGRID - A database of protein and genetic interactions.

57663

DroID - A comprehensive database of gene and protein interactions.

FBgn0003517

DRSC - Results frm RNAi screens

FBgn0003517

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0003517

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG14792-RA

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0003517

FlyMine - An integrated database for Drosophila genomics

FBgn0003517

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

31106

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

Ribosome

MIST (protein-protein) - An integrated Molecular Interaction Database

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synonyms and Secondary IDs (24)

Reported As

Symbol Synonym

37LRP/p40

(Ardini et al., 1998)

CG14792

(Kolkhof et al., 2017, Rosa-Ferreira et al., 2015, Fukuoh et al., 2014, Schertel et al., 2013, Jaspers et al., 2012, Cammarato et al., 2011, Müller et al., 2010, Hansen et al., 2009, Keleman et al., 2009.8.5, Liu et al., 2009, Perkins et al., 2009, Hughes et al., 2008, Goshima et al., 2007, Marygold et al., 2007, Huang et al., 2005, Nakahara et al., 2005, Arbeitman et al., 2004, Benos, 2000.12.13)

EG:80H7.6

(Benos et al., 2001, Benos, 2000.12.13)

Lam-r

P40

(Marhold et al., 2002, Torok et al., 1999)

Rp 40

(Alonso and Santaren, 2006)

Rp40

(Kiss et al., 1998)

RpSA

(Marygold et al., 2007, Ashburner and Marygold, 2004.7.2)

STA

(Liu et al., 2009)

(Brogna et al., 2002)

Sta

(Tokusumi et al., 2012)

anon-EST:Liang-2.56

chrX:1339078..1339216

(Will et al., 2013)

clone 2.56

(Liang and Biggin, 1998)

k14

(Kim, 1991)

l(1)2Af

l(1)G0130

(Schäfer et al., 1999.3.29, Schäfer et al., 1999.6.15)

l(1)G0448

(Schäfer et al., 1999.12.14)

Name Synonyms

Laminin receptor

(de Morais Guedes et al., 2003)

Laminin-receptor

Ribosomal protein SA

(Ashburner and Marygold, 2004.7.2)

Stubarista

(Liu et al., 2009, Bielinski and Mumby, 2007, Melnick, 1992)

stubarista

(Jaspers et al., 2012, Cammarato et al., 2011, Carpenter et al., 2009, Creagh et al., 2009, Martin et al., 2005)

Secondary FlyBase IDs

FBgn0010239
FBgn0026668
FBgn0029057

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (132)

The following external sites may use different assemblies or annotations than FlyBase.

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