FB2019_04, released Aug 22, 2019

Gene: Dmel\stau

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General Information
Symbol
Dmel\stau
Species
D. melanogaster
Name
staufen
Annotation Symbol
CG5753
Feature Type
protein_coding_gene
FlyBase ID
FBgn0003520
Gene Model Status
Current
Stock Availability
14 publicly available
Gene Snapshot
staufen (stau) encodes a double-stranded RNA binding protein involved in mRNA localization. It contributes to anterior and posterior patterning, nervous system development and long term memory. [Date last reviewed: 2019-03-14]
Other Summaries
Also Known As
dStau
Key Links
Genomic Location
Cytogenetic map
55B5-55B7
Sequence location
2R:18,117,896..18,125,779 [-]
Recombination map
2-84
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
mRNA 3'-UTR binding; mRNA binding; protein binding; RNA binding
Predictions / Assertions
double-stranded RNA binding; microtubule binding; mRNA binding
Summaries
Protein Function (UniProtKB)
RNA-binding protein which forms ribonucleoprotein complexes (RNPs) that play critical roles in the localization, translational repression and turnover of RNAs during embryogenesis, neurotransmission and neurogenesis (PubMed:10698941, PubMed:1712672, PubMed:8001156, PubMed:17178403). In the oocyte, essential for the localization of both the osk/oskar mRNA to the posterior pole and bcd/bicoid RNA to the anterior pole, and is therefore required for the correct anterior-posterior patterning of the developing embryo (PubMed:10698941, PubMed:1712672, PubMed:8001156). Association with osk or bcd at their respective poles, appears to promote the formation and stabilization of the ribonucleoprotein complexes (PubMed:1712672, PubMed:8001156). Integral component of diverse neuritic ribonucleoprotein complexes (RNPs) that mediate the transport, translation and turnover of neuronal RNAs during neuorgenesis and the translation repression of synaptic transcripts in preparation for their dendritic targeting (PubMed:17178403).
(UniProt, P25159)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
stau: staufen (T. Schupbach)
Maternal-effect lethal. Embryos from homozygous mothers exhibit a so-called "grandchildless-knirps" phenotype; all eggs lack polar granules and no pole cells are formed; most embryos show variable deletions of abdominal segments, whereby segment A4 is deleted most frequently; larger deletions may delete segments A2 through A7; in extreme cases, anterior parts of segment A1 become fused to posterior parts of segment A8, but telson elements are always present and relatively normal. In addition, embryos show deletions of the anterior-most head structures and the cephalic furrow is shifted anteriorly at gastrulation. Analysis of germline clones indicates that the mutation is germline autonomous (Schupbach and Wieschaus, 1986, Dev. Biol. 113: 443-48).
Summary (Interactive Fly)
Double stranded RNA binding protein - required for the localization of multiple mRNA species during oogenesis and zygotic development -direct binding of Staufen to and mRNAs is a requirement for their subcellular distribution - as a posterior group protein Staufen required for the localization of mRNA to the posterior pole of the oocyte
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
3

Please see the GBrowse view of Dmel\stau or the JBrowse view of Dmel\stau for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.50
Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
stau-RA
FBtr0086783
NM_057403
5240
1026
stau-RB
FBtr0086784
NM_166263
4910
914
stau-RC
FBtr0301614
NM_001169714
3509
1025
Additional Transcript Data and Comments
Reported size (kB)
5.3 (northern blot)
(St. Johnston et al., 1991)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
stau-PA
FBpp0085962
110.3
1026
9.63
NP_476751
AAF57752
stau-PB
FBpp0085963
98.0
914
9.51
NP_725748
AAF57753
stau-PC
FBpp0290829
110.2
1025
9.63
NP_001163185
ACZ94457
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
1026 (aa); 150 (kD observed)
(St. Johnston et al., 1991)
Comments
External Data
Subunit Structure (UniProtKB)
Component of neuronal ribonucleoprotein complexes (RNPs) that contains at least various translational repressor and mRNA turnover proteins such as me31B, tral, Upf1, AGO2 and sometimes Fmr1.
(UniProt, P25159)
Domain
Contains a proline-rich domain. The insertion of this domain in the DRBM 2 domain is required for stau-oskar mRNA localization. DRBM 3 domain binds optimally to stem-loops containing 12 bp (in vitro).
(UniProt, P25159)
Crossreferences
InterPro - A database of protein families, domains and functional sites
PDB - An information portal to biological macromolecular structures
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\stau using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (39 terms)
Molecular Function (6 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
mRNA 3'-UTR binding
inferred from direct assay
(Jenny et al., 2006, Li et al., 1997)
mRNA binding
inferred from direct assay
(Mahoney et al., 2016)
protein binding
inferred from physical interaction with FLYBASE:mira; FB:FBgn0021776
(Jia et al., 2015)
RNA binding
inferred from direct assay
(Landskron et al., 2018)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
double-stranded RNA binding
inferred from sequence or structural similarity
(Lasko, 2000)
traceable author statement
(van Eeden and St. Johnston, 1999)
microtubule binding
non-traceable author statement
(Holloway et al., 2002)
mRNA binding
non-traceable author statement
(Holloway et al., 2002)
Biological Process (20 terms)
Terms Based on Experimental Evidence (10 terms)
CV Term
Evidence
References
anterior/posterior axis specification, embryo
inferred from genetic interaction with FLYBASE:mira; FB:FBgn0021776
(Irion et al., 2006)
intracellular mRNA localization
inferred from mutant phenotype
(Landskron et al., 2018)
pole plasm assembly
inferred from mutant phenotype
(Raff et al., 1990)
pole plasm protein localization
inferred from mutant phenotype
(Irion et al., 2006)
pole plasm RNA localization
inferred from mutant phenotype
(Raff et al., 1990)
positive regulation of cytoplasmic mRNA processing body assembly
inferred from mutant phenotype
(Eulalio et al., 2007)
positive regulation of synaptic growth at neuromuscular junction
inferred from mutant phenotype
(Gardiol and St Johnston, 2014)
protein localization to synapse
inferred from mutant phenotype
(Gardiol and St Johnston, 2014)
regulation of pole plasm oskar mRNA localization
inferred from genetic interaction with FLYBASE:mira; FB:FBgn0021776
(Irion et al., 2006)
RNA localization
inferred from mutant phenotype
(Li et al., 1997)
Terms Based on Predictions or Assertions (13 terms)
CV Term
Evidence
References
asymmetric neuroblast division
non-traceable author statement
(Li et al., 1997)
asymmetric protein localization involved in cell fate determination
traceable author statement
(Bardin et al., 2004)
bicoid mRNA localization
traceable author statement
(Johnstone and Lasko, 2001, Ding et al., 1993)
non-traceable author statement
(van Eeden and St. Johnston, 1999)
intracellular mRNA localization
traceable author statement
(Holloway et al., 2002, Sardet et al., 2002)
long-term memory
traceable author statement
(Greenspan, 2003)
neuroblast fate determination
traceable author statement
(Bardin et al., 2004)
oogenesis
traceable author statement
(Wylie, 1999)
pole plasm oskar mRNA localization
traceable author statement
(Farina and Singer, 2002, Johnstone and Lasko, 2001, Mahowald, 2001)
pole plasm protein localization
traceable author statement
(Breitwieser et al., 1996)
positive regulation of oskar mRNA translation
non-traceable author statement
(Leatherman and Jongens, 2003, Tekotte and Davis, 2002)
protein localization
traceable author statement
(Sardet et al., 2002)
regulation of oskar mRNA translation
traceable author statement
(Mahowald, 2001, van Eeden and St. Johnston, 1999)
regulation of pole plasm oskar mRNA localization
traceable author statement
(van Eeden and St. Johnston, 1999)
Cellular Component (13 terms)
Terms Based on Experimental Evidence (13 terms)
CV Term
Evidence
References
apical cortex
inferred from direct assay
(Li et al., 1997)
apical part of cell
inferred from direct assay
(Fuerstenberg et al., 1998)
apical plasma membrane
inferred from direct assay
(Shen et al., 1998)
basal cortex
inferred from direct assay
(Landskron et al., 2018, Fuerstenberg et al., 1998)
basal plasma membrane
inferred from direct assay
(Shen et al., 1998)
cell cortex
inferred from direct assay
(Li et al., 1997)
cytoplasm
inferred from direct assay
(Fuerstenberg et al., 1998)
germ plasm
inferred from direct assay
(assigned by BHF-UCL )
(Li et al., 2009)
messenger ribonucleoprotein complex
inferred from direct assay
(assigned by UniProt )
(Barbee et al., 2006)
neuronal cell body
inferred from direct assay
(assigned by UniProt )
(Hillebrand et al., 2010, Barbee et al., 2006)
neuronal ribonucleoprotein granule
inferred from direct assay
(assigned by UniProt )
(Hillebrand et al., 2010, Barbee et al., 2006)
P-body
inferred from direct assay
(Eulalio et al., 2007)
subsynaptic reticulum
inferred from direct assay
(Gardiol and St Johnston, 2014)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
basal cortex
non-traceable author statement
(Cayouette and Raff, 2002)
traceable author statement
(Bardin et al., 2004)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
fertilized egg stage
fertilized egg | ubiquitous
(St. Johnston et al., 1991)
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 1 -- 4
organism
(Kang et al., 2009)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal ectoderm
(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 11 -- 12
anterior midgut primordium
(Fisher et al., 2012)
central brain primordium
(Fisher et al., 2012)
dorsal epidermis primordium
(Fisher et al., 2012)
dorsal sensory complex primordium
(Fisher et al., 2012)
posterior midgut primordium
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
embryonic hindgut
(Fisher et al., 2012)
embryonic/larval midgut
(Fisher et al., 2012)
embryonic/larval nervous system
(Fisher et al., 2012)
ventral nerve cord
(Fisher et al., 2012)
embryonic stage 14
ventral nerve cord
(Kang et al., 2009)
adult stageoogenesis stage S3 -- S4
female germline stem cell
(St. Johnston et al., 1991)
adult stage & oogenesis stage S6
oocyte | presumptive
(St. Johnston et al., 1991)
adult stageoogenesis stage S6 -- S10
nurse cell
(St. Johnston et al., 1991)
Additional Descriptive Data
stau is maternally expressed in the embryo and later expression is observed in a symmetric pattern along the ventral nerve cord.
(Kang et al., 2009)
stau transcript is first detected in germline cells at stage S3-S4 of oogenesis. By stage S6, stau expression is concentrated in the presumptive oocyte, but is also detected in the nurse cells. By stage S10, stau transcript is predominantly in the nurse cells, which later transfer their cytoplasm to the oocyte. Thus, stau transcript is uniformly distributed in the freshly laid egg. At cellularization, stau transcript is found in the basal regions of the blastoderm cells, and persists until after gastrulation.
(St. Johnston et al., 1991)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage & oogenesis stage S10
oocyte | posterior
(Breitwieser et al., 1996)
distribution deduced from reporter or direct label
Stage
Tissue/Position (including subcellular localization)
Reference
oogenesis stage S11
oocyte | anterior
(Martin et al., 2003)
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
embryonic neuroblast

Comment: localized in a dense basal cresent as cells enter mitosis

(Fuerstenberg et al., 1998)
embryonic neuroblast

Comment: localized in a diffuse apical cresent in mitotic cells

(Fuerstenberg et al., 1998)
embryonic ganglion mother cell

Comment: post-mitotic localization

(Fuerstenberg et al., 1998)
cleavage stage
organism | anterior
(St. Johnston et al., 1991)
embryonic stage 1
organism | 90-100% egg length

Comment: 95-100% egg length

(Ferrandon et al., 1994)
organism | 0-10% egg length

Comment: 0-5% egg length

(Ferrandon et al., 1994)
organism | terminal expression pattern
(Ferrandon et al., 1994)
embryonic stage 1 -- 5
organism | posterior
(Breitwieser et al., 1996)
embryonic stage 4
pole cell
(St. Johnston et al., 1991)
extended germ band stage
presumptive embryonic/larval nervous system
(St. Johnston et al., 1991)
embryonic stage 13
central nervous system
(St. Johnston et al., 1991)
third instar larval stage
embryonic/larval neuromuscular junction
(Gardiol and St Johnston, 2014)
type I bouton

Comment: postsynaptic side

(Gardiol and St Johnston, 2014)
adult stageoogenesis stage S8 -- S10B
oocyte | posterior
(St. Johnston et al., 1991)
adult stageoogenesis stage S10B -- S14
nurse cell
(St. Johnston et al., 1991)
oogenesis stage S3 -- S4
oocyte | presumptive
(St. Johnston et al., 1991)
oogenesis stage S6 -- S8
polar follicle cell | posterior
(Xi et al., 2003)
Additional Descriptive Data
stau protein is localized to the apical cortex and cytoplasm in late interphase neuroblasts. From metaphase through to telophase, stau protein is localized in a basal cortical crescent. At cytokinesis, it segregates into the daughter ganglion mother cell (GMC). stau protein localization is not microtubule-dependent.
(Gardiol and St Johnston, 2014, Broadus et al., 1998)
A GFP-stau protein fusion was localized in live oocytes to the anterior region in the same position as the bcd transcript.
(Martin et al., 2003)
In stage 10 oocytes, vas protein, osk protein, and stau protein colocalize at the posterior pole. In early embryos, vas protein and osk protein localize to the polar granules but stau protein does not colocalize with them. It is present in a thin crescent apposed closely to the posterior cortex and disappears before the pole cell stage. A GFP-Vas fusion protein was used to determine the vas protein distribution.
(Matsuzaki et al., 1998, Breitwieser et al., 1996)
In a freshly laid fertilized embryo, stau protein is detected at the anterior and posterior poles. An unfertilized egg displays initial stau protein localization, which diffuses as the egg ages.
(Schuldt et al., 1998, Ferrandon et al., 1994)
stau protein localizes to the apical cortex of mitotic neuroblasts in late interphase and early prophase. It then localizes to the basal cortex in late prophase, metaphase, anaphase, and telophase. After mitosis, it segregates into the basal daughter cell.
(Shen et al., 1998, St. Johnston et al., 1991)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
apical cortex
inferred from direct assay
(Li et al., 1997)
apical part of cell
inferred from direct assay
(Fuerstenberg et al., 1998)
apical plasma membrane
inferred from direct assay
(Shen et al., 1998)
basal cortex
inferred from direct assay
(Landskron et al., 2018, Fuerstenberg et al., 1998)
basal plasma membrane
inferred from direct assay
(Shen et al., 1998)
cell cortex
inferred from direct assay
(Li et al., 1997)
cytoplasm
inferred from direct assay
(Fuerstenberg et al., 1998)
germ plasm
inferred from direct assay
(assigned by BHF-UCL )
(Li et al., 2009)
messenger ribonucleoprotein complex
inferred from direct assay
(assigned by UniProt )
(Barbee et al., 2006)
neuronal cell body
inferred from direct assay
(assigned by UniProt )
(Hillebrand et al., 2010, Barbee et al., 2006)
neuronal ribonucleoprotein granule
inferred from direct assay
(assigned by UniProt )
(Hillebrand et al., 2010, Barbee et al., 2006)
P-body
inferred from direct assay
(Eulalio et al., 2007)
subsynaptic reticulum
inferred from direct assay
(Gardiol and St Johnston, 2014)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\stau in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 18 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 23 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of stau
Transgenic constructs containing regulatory region of stau
Deletions and Duplications ( 24 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal | maternal effect
lethal | maternal effect | recessive
lethal | maternal effect | recessive | heat sensitive
lethal | non-rescuable maternal effect
lethal - all die before end of embryonic stage | germline clone | non-rescuable maternal effect | recessive
lethal - all die before end of embryonic stage | maternal effect | recessive
lethal - all die before end of pupal stage, with Scer\GAL4pnr-MD237
Sterility
Allele
female sterile (with Df(2R)BSC334)
female sterile (with Df(2R)ED3610)
female sterile | maternal effect
female sterile | recessive
grandchildless
grandchildless | recessive
male sterile | maternal effect
Other Phenotypes
Allele
memory defective | heat sensitive (with stau2)
memory defective | heat sensitive (with stau3)
neuroanatomy defective | somatic clone, with Scer\FLP1UAS.cUa, Scer\GAL4Act.PU, Scer\GAL4eve.RRK
neuroanatomy defective | third instar larval stage (with Df(2R)Pcl7B)
some die during embryonic stage | non-rescuable maternal effect | recessive
some die during embryonic stage | recessive | maternal effect | recessive
some die during pupal stage, with Scer\GAL4pnr-MD237
wild-type
Phenotype manifest in
Allele
abdominal segment
cephalic furrow | maternal effect
dendrite | somatic clone, with Scer\FLP1UAS.cUa, Scer\GAL4Act.PU, Scer\GAL4eve.RRK
dorsal arm of pharyngeal sclerite | maternal effect (with Df(2R)PC4)
embryo | germline clone | maternal effect | posterior
embryonic/larval neuromuscular junction | third instar larval stage (with Df(2R)Pcl7B)
embryonic abdomen
embryonic abdomen | maternal effect
embryonic abdominal segment 1
embryonic abdominal segment 2
embryonic abdominal segment 3
embryonic abdominal segment 4
embryonic abdominal segment 5
embryonic abdominal segment 6
embryonic abdominal segment 7
embryonic abdominal segment 8
embryonic abdominal segment 9
embryonic abdominal segment 10
embryonic abdominal segment 11
embryonic abdominal segment | maternal effect
embryonic abdominal segment | maternal effect (with Df(2R)PC4)
embryonic abdominal segment | non-rescuable maternal effect
embryonic head
embryonic head | anterior
embryonic head | anterior | maternal effect
embryonic head | germline clone | maternal effect
embryonic head | maternal effect
embryonic labral segment | non-rescuable maternal effect
median tooth | maternal effect (with Df(2R)PC4)
pole cell
pole cell | maternal effect
pole cell | non-rescuable maternal effect
pole granule | maternal effect
pole plasm
RP2 motor neuron | somatic clone, with Scer\FLP1UAS.cUa, Scer\GAL4Act.PU, Scer\GAL4eve.RRK
type Ib terminal bouton | third instar larval stage (with Df(2R)Pcl7B)
ventral arm of pharyngeal sclerite | maternal effect (with Df(2R)PC4)
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (4)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\STAU1
11 of 15
Yes
Yes
Hsap\STAU2
11 of 15
Yes
Yes
Hsap\PRKRA
1 of 15
No
No
Hsap\TARBP2
1 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (5)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Stau1
10 of 15
Yes
Yes
Mmus\Stau2
8 of 15
No
Yes
Mmus\Adarb1
1 of 15
No
No
Mmus\Prkra
1 of 15
No
No
Mmus\Tarbp2
1 of 15
No
No
Rattus norvegicus (Norway rat) (5)
Rnor\Stau1
7 of 13
Yes
Yes
Rnor\Stau2
4 of 13
No
Yes
Rnor\Adarb1
1 of 13
No
No
Rnor\Prkra
1 of 13
No
No
Rnor\Tarbp2
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (4)
Xtro\stau2
8 of 12
Yes
Yes
Xtro\stau1
5 of 12
No
Yes
Xtro\adarb1
1 of 12
No
No
Xtro\tarbp2
1 of 12
No
No
Danio rerio (Zebrafish) (4)
Drer\stau1
11 of 15
Yes
Yes
Drer\stau2
11 of 15
Yes
Yes
Drer\prkra
1 of 15
No
No
Drer\tarbp2
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\stau-1
13 of 15
Yes
Yes
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091906QT )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\stau
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00003128
Drosophila simulans
Dsim\GD25416
Drosophila sechellia
Dsec\GM19927
Drosophila erecta
Dere\GG20993
Drosophila yakuba
Dyak\GE13936
Drosophila ananassae
Dana\GF13203
Drosophila pseudoobscura pseudoobscura
Dpse\GA19106
Drosophila persimilis
Dper\GL10536
Drosophila willistoni
Dwil\GK22054
Drosophila virilis
Dvir\stau
Drosophila mojavensis
Dmoj\GI19273
Drosophila grimshawi
Dgri\GH20445
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150495 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_13803
Mayetiola destructor
Hessian fly
Mdes\Mdes012280
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL007470
Anopheles darlingi
American malaria mosquito
Adar\ADAC002263
Anopheles gambiae
Malaria mosquito
Agam\AGAP007478
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ000296
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W05H4 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA002695
Danaus plexippus
Monarch butterfly
Dple\DPOGS201522-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL015506
Apis florea
Little honeybee
Aflo\2345803364
Apis mellifera
Western honey bee
Amel\GB54264
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP10755
Bombus terrestris
Buff-tailed bumblebee
Bter\15213444
Linepithema humile
Argentine ant
Lhum\LH20434
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002503
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG013994
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_06727
Tribolium castaneum
Red flour beetle
Tcas\GLEAN_08157
Tribolium castaneum
Red flour beetle
Tcas\stau
Pediculus humanus
Human body louse
Phum\PHUM616960
Rhodnius prolixus
Kissing bug
Rpro\RPRC010019
Cimex lectularius
Bed bug
Clec\CLEC007684
Cimex lectularius
Bed bug
Clec\CLEC007684-PB
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI008002
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_08079
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X04V8 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR004496
Ixodes scapularis
Black-legged tick
Isca\ISCW004051
Stegodyphus mimosarum
African social velvet spider
Smim\KFM77620.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur29g00400
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_321006
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_324210
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G07A0 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Staufen1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Staufen2
Gallus gallus
Domestic chicken
Ggal\STAU2
Gallus gallus
Domestic chicken
Ggal\STAU1
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (2)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
r2d2
2 of 10
loqs
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 3 )
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    STAU1; staufen double-stranded RNA binding protein 1
    11 of 15
    601716
        STAU2; staufen double-stranded RNA binding protein 2
        11 of 15
        605920
            Functional Complementation Data
            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
            Interactions
            Summary of Physical Interactions
            esyN Network Diagram
            Show neighbor-neighbor interactions:
            Select Layout:
            Legend:
            Protein
            RNA
            Selected Interactor(s)
            Interactions Browser
            View in Interactions Browser
            Please see the Physical Interaction reports below for full details
            protein-protein
            Physical Interaction
            Assay
            References
            stau
            anti tag coimmunoprecipitation, western blot, anti bait coimmunoprecipitation, partial DNA sequence identification by hybridization
            (Lu et al., 2018, Laver et al., 2013)
            stau - Khc
            anti tag coimmunoprecipitation, western blot
            (Lu et al., 2018)
            stau - SmB
            anti tag coimmunoprecipitation, western blot
            (Gonsalvez et al., 2010)
            stau - Syp
            anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation
            (Landskron et al., 2018)
            stau - Tm1
            anti tag coimmunoprecipitation, western blot
            (Gáspár et al., 2017)
            stau - baz
            anti bait coimmunoprecipitation, western blot
            (Wodarz et al., 1999)
            stau - brat
            anti tag coimmunoprecipitation, primer specific pcr, pull down, molecular weight estimation by staining
            (Jia et al., 2015, Loedige et al., 2015)
            stau - cup
            anti bait coimmunoprecipitation, western blot, pull down
            (Piccioni et al., 2009)
            stau - didum
            anti tag coimmunoprecipitation, western blot
            (Lu et al., 2018)
            stau - insc
            pull down, autoradiography, two hybrid
            (Li et al., 1997)
            stau - klar
            anti tag coimmunoprecipitation, western blot, anti bait coimmunoprecipitation
            (Gaspar et al., 2014)
            stau - mira
            molecular sieving, predetermined participant, pull down, autoradiography, two hybrid, x-ray crystallography, anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, anti tag western blot, isothermal titration calorimetry
            (Jia et al., 2015, Petritsch et al., 2003, Schuldt et al., 1998, Shen et al., 1998)
            stau - osk
            anti tag coimmunoprecipitation, partial DNA sequence identification by hybridization, two hybrid, quantitative reverse transcription pcr, anti bait coimmunoprecipitation, pull down, autoradiography
            (Lu et al., 2018, Gaspar et al., 2014, Laver et al., 2013, Breitwieser et al., 1996)
            RNA-protein
            Physical Interaction
            Assay
            References
            stau
            anti tag coimmunoprecipitation, western blot, anti bait coimmunoprecipitation, partial DNA sequence identification by hybridization
            (Lu et al., 2018, Laver et al., 2013)
            stau - 825-Oak
            anti bait coimmunoprecipitation, partial DNA sequence identification by hybridization
            (Laver et al., 2013)
            stau - AhcyL1
            anti bait coimmunoprecipitation, partial DNA sequence identification by hybridization
            (Laver et al., 2013)
            stau - CG12519
            anti bait coimmunoprecipitation, partial DNA sequence identification by hybridization
            (Laver et al., 2013)
            stau - CG14100
            anti tag coimmunoprecipitation, partial DNA sequence identification by hybridization, anti bait coimmunoprecipitation
            (Laver et al., 2013)
            stau - CG14915
            anti bait coimmunoprecipitation, partial DNA sequence identification by hybridization
            (Laver et al., 2013)
            stau - CG17270
            anti bait coimmunoprecipitation, partial DNA sequence identification by hybridization
            (Laver et al., 2013)
            stau - CG17724
            anti tag coimmunoprecipitation, partial DNA sequence identification by hybridization, anti bait coimmunoprecipitation
            (Laver et al., 2013)
            stau - CG18273
            anti bait coimmunoprecipitation, partial DNA sequence identification by hybridization, anti tag coimmunoprecipitation
            (Laver et al., 2013)
            stau - CG31688
            anti bait coimmunoprecipitation, partial DNA sequence identification by hybridization, anti tag coimmunoprecipitation
            (Laver et al., 2013)
            stau - CG32212
            anti bait coimmunoprecipitation, partial DNA sequence identification by hybridization, anti tag coimmunoprecipitation
            (Laver et al., 2013)
            stau - CG32214
            anti bait coimmunoprecipitation, partial DNA sequence identification by hybridization, anti tag coimmunoprecipitation
            (Laver et al., 2013)
            stau - CG32267
            anti bait coimmunoprecipitation, partial DNA sequence identification by hybridization
            (Laver et al., 2013)
            stau - CG32756
            anti tag coimmunoprecipitation, partial DNA sequence identification by hybridization
            (Laver et al., 2013)
            stau - CG32767
            anti tag coimmunoprecipitation, partial DNA sequence identification by hybridization
            (Laver et al., 2013)
            stau - CG33932
            anti tag coimmunoprecipitation, partial DNA sequence identification by hybridization
            (Laver et al., 2013)
            stau - CG43736
            anti tag coimmunoprecipitation, partial DNA sequence identification by hybridization
            (Laver et al., 2013)
            stau - CG44774
            anti bait coimmunoprecipitation, partial DNA sequence identification by hybridization, anti tag coimmunoprecipitation
            (Laver et al., 2013)
            stau - CG4788
            anti bait coimmunoprecipitation, partial DNA sequence identification by hybridization
            (Laver et al., 2013)
            stau - CG5830
            anti tag coimmunoprecipitation, partial DNA sequence identification by hybridization
            (Laver et al., 2013)
            stau - CG5966
            anti tag coimmunoprecipitation, partial DNA sequence identification by hybridization
            (Laver et al., 2013)
            stau - CR14578
            anti bait coimmunoprecipitation, partial DNA sequence identification by hybridization
            (Laver et al., 2013)
            stau - CR18166
            anti bait coimmunoprecipitation, partial DNA sequence identification by hybridization
            (Laver et al., 2013)
            stau - Dsp1
            anti bait coimmunoprecipitation, partial DNA sequence identification by hybridization, anti tag coimmunoprecipitation
            (Laver et al., 2013)
            stau - FASN1
            anti tag coimmunoprecipitation, partial DNA sequence identification by hybridization, anti bait coimmunoprecipitation
            (Laver et al., 2013)
            stau - Flo2
            anti tag coimmunoprecipitation, partial DNA sequence identification by hybridization
            (Laver et al., 2013)
            stau - Kdm4B
            anti bait coimmunoprecipitation, partial DNA sequence identification by hybridization
            (Laver et al., 2013)
            stau - MED14
            anti bait coimmunoprecipitation, partial DNA sequence identification by hybridization
            (Laver et al., 2013)
            stau - Mms19
            anti bait coimmunoprecipitation, partial DNA sequence identification by hybridization
            (Laver et al., 2013)
            stau - Nf1
            anti bait coimmunoprecipitation, partial DNA sequence identification by hybridization
            (Laver et al., 2013)
            stau - Pc
            anti bait coimmunoprecipitation, partial DNA sequence identification by hybridization, anti tag coimmunoprecipitation
            (Laver et al., 2013)
            stau - Pepck1
            anti bait coimmunoprecipitation, partial DNA sequence identification by hybridization
            (Laver et al., 2013)
            stau - Pka-R1
            anti tag coimmunoprecipitation, partial DNA sequence identification by hybridization
            (Laver et al., 2013)
            stau - Pp4-19C
            anti bait coimmunoprecipitation, partial DNA sequence identification by hybridization, anti tag coimmunoprecipitation
            (Laver et al., 2013)
            stau - Ppa
            anti tag coimmunoprecipitation, partial DNA sequence identification by hybridization, anti bait coimmunoprecipitation
            (Laver et al., 2013)
            stau - Prx6005
            anti bait coimmunoprecipitation, partial DNA sequence identification by hybridization, anti tag coimmunoprecipitation
            (Laver et al., 2013)
            stau - Rap1
            anti tag coimmunoprecipitation, partial DNA sequence identification by hybridization
            (Laver et al., 2013)
            stau - RpS27
            anti bait coimmunoprecipitation, partial DNA sequence identification by hybridization
            (Laver et al., 2013)
            stau - Spred
            anti tag coimmunoprecipitation, partial DNA sequence identification by hybridization
            (Laver et al., 2013)
            stau - Thor
            anti tag coimmunoprecipitation, quantitative reverse transcription pcr
            (Mahoney et al., 2016)
            stau - Tob
            anti tag coimmunoprecipitation, partial DNA sequence identification by hybridization
            (Laver et al., 2013)
            stau - Traf6
            anti tag coimmunoprecipitation, partial DNA sequence identification by hybridization
            (Laver et al., 2013)
            stau - Vha26
            anti bait coimmunoprecipitation, partial DNA sequence identification by hybridization
            (Laver et al., 2013)
            stau - VhaAC45
            anti bait coimmunoprecipitation, partial DNA sequence identification by hybridization, anti tag coimmunoprecipitation
            (Laver et al., 2013)
            stau - VhaPPA1-1
            anti bait coimmunoprecipitation, partial DNA sequence identification by hybridization, anti tag coimmunoprecipitation
            (Laver et al., 2013)
            stau - bcd
            anti bait coimmunoprecipitation, partial DNA sequence identification by hybridization, anti tag coimmunoprecipitation, primer specific pcr, rna three hybrid
            (Laver et al., 2013, Laver et al., 2012, Irion and St Johnston, 2007)
            stau - brat
            anti tag coimmunoprecipitation, primer specific pcr, pull down, molecular weight estimation by staining
            (Jia et al., 2015, Loedige et al., 2015)
            stau - bves
            anti tag coimmunoprecipitation, partial DNA sequence identification by hybridization
            (Laver et al., 2013)
            stau - cpb
            anti bait coimmunoprecipitation, partial DNA sequence identification by hybridization, anti tag coimmunoprecipitation
            (Laver et al., 2013)
            stau - cpx
            anti tag coimmunoprecipitation, quantitative reverse transcription pcr
            (Mahoney et al., 2016)
            stau - dap
            anti tag coimmunoprecipitation, partial DNA sequence identification by hybridization, anti bait coimmunoprecipitation
            (Laver et al., 2013)
            stau - flfl
            anti bait coimmunoprecipitation, partial DNA sequence identification by hybridization, anti tag coimmunoprecipitation
            (Laver et al., 2013)
            stau - fus
            anti tag coimmunoprecipitation, partial DNA sequence identification by hybridization
            (Laver et al., 2013)
            stau - hpRNA:CR32207
            anti tag coimmunoprecipitation, partial DNA sequence identification by hybridization, anti bait coimmunoprecipitation
            (Laver et al., 2013)
            stau - kuk
            anti bait coimmunoprecipitation, partial DNA sequence identification by hybridization
            (Laver et al., 2013)
            stau - l(3)neo38
            anti tag coimmunoprecipitation, partial DNA sequence identification by hybridization
            (Laver et al., 2013)
            stau - lncRNA:cherub
            anti bait coimmunoprecipitation, quantitative reverse transcription pcr
            (Landskron et al., 2018)
            stau - mahe
            anti tag coimmunoprecipitation, partial DNA sequence identification by hybridization
            (Laver et al., 2013)
            stau - nonA
            anti tag coimmunoprecipitation, partial DNA sequence identification by hybridization
            (Laver et al., 2013)
            stau - nub
            anti tag coimmunoprecipitation, partial DNA sequence identification by hybridization
            (Laver et al., 2013)
            stau - oc
            anti tag coimmunoprecipitation, partial DNA sequence identification by hybridization
            (Laver et al., 2013)
            stau - osk
            anti tag coimmunoprecipitation, partial DNA sequence identification by hybridization, two hybrid, quantitative reverse transcription pcr, anti bait coimmunoprecipitation, pull down, autoradiography
            (Lu et al., 2018, Gaspar et al., 2014, Laver et al., 2013, Breitwieser et al., 1996)
            stau - pros
            pull down, autoradiography, anti tag coimmunoprecipitation, partial DNA sequence identification by hybridization, anti bait coimmunoprecipitation
            (Laver et al., 2013, Li et al., 1997)
            stau - ps
            anti tag coimmunoprecipitation, partial DNA sequence identification by hybridization
            (Laver et al., 2013)
            stau - put
            anti tag coimmunoprecipitation, partial DNA sequence identification by hybridization
            (Laver et al., 2013)
            stau - seq
            anti bait coimmunoprecipitation, partial DNA sequence identification by hybridization
            (Laver et al., 2013)
            stau - sl
            anti tag coimmunoprecipitation, partial DNA sequence identification by hybridization
            (Laver et al., 2013)
            stau - spen
            anti bait coimmunoprecipitation, partial DNA sequence identification by hybridization
            (Laver et al., 2013)
            stau - sqz
            anti tag coimmunoprecipitation, partial DNA sequence identification by hybridization, anti bait coimmunoprecipitation
            (Laver et al., 2013)
            stau - vir
            anti bait coimmunoprecipitation, partial DNA sequence identification by hybridization
            (Laver et al., 2013)
            stau - vn
            anti tag coimmunoprecipitation, partial DNA sequence identification by hybridization
            (Laver et al., 2013)
            stau - zld
            anti bait coimmunoprecipitation, partial DNA sequence identification by hybridization
            (Laver et al., 2013)
            RNA-RNA
            Physical Interaction
            Assay
            References
            stau - mir-184
            luminiscence technology
            (Iovino et al., 2009)
            Summary of Genetic Interactions
            esyN Network Diagram
            esyN Network Key:
            Suppression
            Enhancement
            View in Interactions Browser
            Please look at the allele data for full details of the genetic interactions
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            BicD|stau
            suppressible
            ctp
            (Navarro et al., 2004)
            BicD|stau
            suppressible
            Dhc64C
            (Navarro et al., 2004)
            BicD|stau
            suppressible
            egl
            (Navarro et al., 2004)
            stau
            enhanceable
            Fmr1
            (Bolduc et al., 2008)
            BicD|stau
            suppressible
            Lis-1
            (Navarro et al., 2004)
            stau
            enhanceable
            neb
            (Ruden et al., 1997)
            stau
            suppressible
            stau::Mdoa\stau
            (Micklem et al., 2000)
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            Adf1
            suppressible
            stau
            (Timmerman et al., 2013)
            BicD
            suppressible
            Lis-1|stau
            (Navarro et al., 2004)
            BicD
            suppressible
            ctp|stau
            (Navarro et al., 2004)
            BicD
            suppressible
            Dhc64C|stau
            (Navarro et al., 2004)
            BicD
            suppressible
            egl|stau
            (Navarro et al., 2004)
            Dref
            suppressible
            stau
            (Ida et al., 2009)
            Fmr1
            enhanceable
            stau
            (Bolduc et al., 2008)
            Ge-1
            enhanceable
            stau
            (Fan et al., 2011)
            mira
            suppressible
            stau
            (Irion et al., 2006)
            neb
            enhanceable
            stau
            (Ruden et al., 1997)
            osk
            suppressible
            stau
            (Micklem et al., 2000)
            External Data
            Subunit Structure (UniProtKB)
            Component of neuronal ribonucleoprotein complexes (RNPs) that contains at least various translational repressor and mRNA turnover proteins such as me31B, tral, Upf1, AGO2 and sometimes Fmr1.
            (UniProt, P25159 )
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            DroID - A comprehensive database of gene and protein interactions.
            InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Pathways
            Gene Group - Pathway Membership (FlyBase)
            External Data
            Linkouts
            Genomic Location and Detailed Mapping Data
            Chromosome (arm)
            2R
            Recombination map
            2-84
            Cytogenetic map
            55B5-55B7
            Sequence location
            2R:18,117,896..18,125,779 [-]
            FlyBase Computed Cytological Location
            Cytogenetic map
            Evidence for location
            55B5-55B7
            Limits computationally determined from genome sequence between P{PZ}grh06850&P{lacW}olf186-Fk11505 and P{PZ}Hsf03091&P{EP}Dgp-1EP731
            Experimentally Determined Cytological Location
            Cytogenetic map
            Notes
            References
            55A-55B
            (determined by in situ hybridisation)
            (St. Johnston et al., 1991)
            Experimentally Determined Recombination Data
            Location
            2-84
            (FlyBase, 2016)
            2-88.7
            (Comeron et al., 2012)
            2-86
            (Schupbach and Wieschaus, 1989)
            2-83.5
            (Tearle and Nusslein-Volhard, 1987)
            Left of (cM)
            Right of (cM)
            (Doane, 1999)
            Notes
            Stocks and Reagents
            Stocks (14)
            Genomic Clones (22)
            cDNA Clones (102)
             

            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

            cDNA clones, fully sequences
            BDGP DGC clones
            Other clones
              Drosophila Genomics Resource Center cDNA clones

              For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

              cDNA Clones, End Sequenced (ESTs)
              BDGP DGC clones
              Other clones
              RNAi and Array Information
              Linkouts
              DRSC - Results frm RNAi screens
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              Antibody Information
              Laboratory Generated Antibodies
               
              monoclonal
              (Laver et al., 2012)
              polyclonal
              (Krauss et al., 2009, St. Johnston et al., 1991)
              Commercially Available Antibodies
               
              Other Information
              Relationship to Other Genes
              Source for database identify of
              Source for identity of: stau CG5753
              (Li, 1999.11)
              Source for database merge of
              Additional comments
              Other Comments
              stau is required for localisation of cora mRNA and protein at the postsynaptic side of the neuromuscular junction.
              (Gardiol and St Johnston, 2014)
              stau has a role in long-term memory.
              (Dubnau et al., 2003)
              dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
              (Kiger et al., 2003)
              stau is not required for the cell fate decision in the NB6-4T lineage.
              (Akiyama-Oda et al., 2000)
              Distinct domains of stau mediate microtubule and actin based MRNA transport.
              (Micklem et al., 2000)
              pros mRNA and the RNA-binding protein stau are asymmetrically localised in mitotic neuroblasts and are specifically partitioned into the GMC, as is pros protein. stau is required for localisation of pros RNA but not of pros protein. Loss of localisation of stau or of pros RNA alters GMC development, but only in embryos with reduced levels of pros protein, suggesting that pros RNA and pros protein act redundantly to specify GMC fate. GMCs do not transcribe the pros gene, showing that inheritance of pros RNA and/or pros proteins from the neuroblast is essential for GMC specification.
              (Broadus et al., 1998)
              mira function is required for asymmetrical localisation of stau protein.
              (Shen et al., 1998)
              insc, pros and stau localisation in neuroblasts in vitro is studied. Extrinsic and intrinsic cues and microfilaments regulate the subcellular localisation of the pros, insc and stau proteins in neuroblasts.
              (Broadus and Doe, 1997)
              Binding of the bcd 3'UTR by stau protein requires a double stranded conformation of the stems within the bcd RNA localisation signal.
              (Ferrandon et al., 1997)
              insc and stau mediate asymmetric localization and segregation of pros RNA during neuroblast cell divisions. stau protein binds the pros RNA 3'UTR, via stau residues 565-661, which lie amino terminal to and distinct from the region of stau required to interact with the insc protein.
              (Li et al., 1997)
              osk, stau, vas and tud are essential for pole plasm formation. stau is required for both osk RNA localisation and translation.
              (Breitwieser et al., 1996)
              Mutants in chic resemble those in capu in that they fail to localize stau protein and osk mRNA to the posterior pole of the developing oocyte.
              (Manseau et al., 1996)
              Multinuclear/multidimensional NMR methods have been used to determine that the stau double stranded RNA binding domain (dsRBD) 3 forms a compact protein domain with an α-β-β-β-α structure. In vitro mutagenesis has identified F43 and T50 as two residues essential for RNA binding.
              (Bycroft et al., 1995)
              Nurse cell-specific genes are functional in the pseudonurse cells of otu mutants, but the transport of pum, otu, ovo and bcd RNAs to the cytoplasm is affected.
              (Heino et al., 1995)
              The stau product associates specifically with both osk and bcd mRNAs to mediate their localizations, but at two distinct stages of development. stau protein is required to anchor bcd mRNA at the anterior of the egg, and is transported with osk mRNA during oogenesis.
              (Ferrandon et al., 1994)
              Distribution of tud protein in mutant embryos has been studied.
              (Bardsley et al., 1993)
              Comparison of bcd and hts transcript distribution in swa, exu and stau mutant embryos indicates different genetic requirements for proper localization of bcd and hts RNAs.
              (Ding et al., 1993)
              The localization of the osk RNA and stau protein in oogenesis do not depend of the product of the psq locus.
              (Siegel et al., 1993)
              Only vas and tud are essential for osk-induced pole cell and abdomen formation, stau is not.
              (Ephrussi and Lehmann, 1992)
              vas, vls and tud (but not stau, capu, or spir) are necessary for the 6xosk mutant phenotypes.
              (Smith et al., 1992)
              Deletion analysis and computer analysis identifies a 65 to 68 amino acid consensus sequence defining the minimal dsDNA binding domain.
              (St. Johnston et al., 1992)
              stau is required specifically for the localization of the posterior signal in the embryo, not the synthesis of the signal. BicD,stau embryos exhibit a duplication of the posterior telson at the anterior: the posterior signal can be active at the anterior independent of stau function. stau gene function is unique among maternal genes as it is required for both the accumulation of the anterior bcd-dependent signal and the posterior nos-dependent signal.
              (Lehmann and Nusslein-Volhard, 1991)
              Mutations in maternal posterior class gene stau do not interact with RpII140wimp.
              (Parkhurst and Ish-Horowicz, 1991)
              The posterior group gene stau is required both for the localization of maternal determinants to the posterior pole of the egg and for bcd RNA to localize correctly to the anterior pole. The stau product is one of the first molecules to localize to the posterior pole of the oocyte, perhaps in association with osk RNA. Once localized, stau product is found in the polar granules and is required to hold other polar granule components at the posterior pole. By the time the egg is laid, stau protein is also concentrated at the anterior pole, in the same region as bcd RNA.
              (St. Johnston et al., 1991)
              stau mutants exhibit deletion of the abdomen and pole plasm and anterior head defects.
              (Gaul and Jäckle, 1990)
              Mature follicles are immunologically stained for asymmetric distribution of ecdysteroid-related antigen. During late oogenesis localisation of the antigen changes dramatically suggesting the antigen plays a role in early embryogenesis and, perhaps, in pattern formation.
              (Grau and Gutzeit, 1990)
              In stau mutant females vas synthesis appears normal but the vas protein is not localized.
              (Hay et al., 1990)
              stau plays a role in polar granule formation.
              (Raff et al., 1990)
              Mutation in stau results in a maternal effect "grandchildless knirps-like" phenotype.
              (Schupbach and Wieschaus, 1989)
              stau mutations disrupt the fourth stage of bcd RNA localization during oogenesis: localization to a spherical region that occupies a slightly dorsal position of the anterior pole.
              (St. Johnston et al., 1989)
              Mutations in stau cause failure of germ cell formation and deletions in the abdominal segments in the embryo.
              (Schupbach and Wieschaus, 1986)
              Origin and Etymology
              Discoverer
              Etymology
              Identification
              External Crossreferences and Linkouts ( 51 )
              Sequence Crossreferences
              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
              UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
              UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
              Other crossreferences
              BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
              Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
              Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
              Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
              Flygut - An atlas of the Drosophila adult midgut
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
              InterPro - A database of protein families, domains and functional sites
              KEGG Genes - Molecular building blocks of life in the genomic space.
              modMine - A data warehouse for the modENCODE project
              PDB - An information portal to biological macromolecular structures
              Linkouts
              BioGRID - A database of protein and genetic interactions.
              DroID - A comprehensive database of gene and protein interactions.
              DRSC - Results frm RNAi screens
              FLIGHT - Cell culture data for RNAi and other high-throughput technologies
              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
              FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
              FlyMine - An integrated database for Drosophila genomics
              Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
              InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
              MIST (protein-protein) - An integrated Molecular Interaction Database
              Synonyms and Secondary IDs (11)
              Reported As
              Symbol Synonym
              CG5753
              (Meadows, 2017.1.11, Ni et al., 2011.7.19, Ni et al., 2010.12.1, Ida et al., 2009, Keleman et al., 2009.8.5, Perkins et al., 2009, Ni et al., 2008, Molnar et al., 2006, Goldstein and Gunawardena, 2000)
              Dmstau
              (DeSousa et al., 2003)
              STAU
              (Sofola et al., 2007, Fierro-Monti and Mathews, 2000)
              Stau
              (Gáspár et al., 2017, Jansen and Niessing, 2012, Ottone et al., 2012, Parton et al., 2011, Poulton et al., 2011, Sun et al., 2011, Tanaka et al., 2011, Vazquez-Pianzola et al., 2011, Yan et al., 2011, Klusza and Deng, 2010, Krahn et al., 2010, Weil et al., 2010, Yu et al., 2010, Yu et al., 2010, McNeil et al., 2009, Shyu et al., 2009, Snee and Macdonald, 2009, Tian and Deng, 2009, Gervais et al., 2008, Li et al., 2008, Lin et al., 2008, Tanaka and Nakamura, 2008, Tian and Deng, 2008, Weil et al., 2008, Yu et al., 2008, Eulalio et al., 2007, Geng and MacDonald, 2007, Irion and St Johnston, 2007, Januschke et al., 2007, Meignin et al., 2007, Nurminsky, 2007, Polesello and Tapon, 2007, Sofola et al., 2007, Song et al., 2007, Geng and Macdonald, 2006, Poulton and Deng, 2006, Yucel and Small, 2006, Minakhina and Steward, 2005)
              Stauf
              (Slack et al., 2007)
              Staufen
              (Landskron et al., 2018)
              dStau
              (Macchi et al., 2003, Daviet et al., 2000)
              stau
              (Whittle and Extavour, 2019, Cao et al., 2016, Sarov et al., 2016, Schwartz et al., 2016, Jambor et al., 2015, Jia et al., 2015, Kavi et al., 2015, Loedige et al., 2015, Gardiol and St Johnston, 2014, Williams et al., 2014, Laver et al., 2013, Morais-de-Sá et al., 2013, Sanghavi et al., 2012, Fan et al., 2011, Chang et al., 2010, Gonsalvez et al., 2010, Besse et al., 2009, Ida et al., 2009, Iovino et al., 2009, Kang et al., 2009, Li et al., 2009, Mhlanga et al., 2009, Sousa-Nunes et al., 2009, Spirov et al., 2009, Venken et al., 2009, Bolduc et al., 2008, Christensen et al., 2008.4.15, He et al., 2008, Zimyanin et al., 2008, Bakal et al., 2007, Christensen et al., 2007.10.29, Irion and St Johnston, 2007, Serbus and Sullivan, 2007, Snee et al., 2007, Sofola et al., 2007, Stark et al., 2007, Ashraf et al., 2006, Doerflinger et al., 2006, Lin et al., 2006, Molnar et al., 2006, Munro et al., 2006, Ni et al., 2006, Weil et al., 2006, Navarro et al., 2004, Hall, 2003, Wang et al., 1994)
              Name Synonyms
              STAUFEN
              (Beraud et al., 2007)
              Staufen
              (Baskar et al., 2019, Gáspár et al., 2017, Nieuwburg et al., 2017, Mahoney et al., 2016, Nashchekin et al., 2016, Gardiol and St Johnston, 2014, Gaspar et al., 2014, Ghosh et al., 2014, Leibfried et al., 2013, Timmerman et al., 2013, Jansen and Niessing, 2012, Kelsom and Lu, 2012, Ottone et al., 2012, Sanghavi et al., 2012, Parton et al., 2011, Poulton et al., 2011, Sun et al., 2011, Tanaka et al., 2011, van Eyk et al., 2011, Vazquez-Pianzola et al., 2011, Yan et al., 2011, Doerflinger et al., 2010, Gonsalvez et al., 2010, Hillebrand et al., 2010, Klusza and Deng, 2010, Krahn et al., 2010, Kim et al., 2009, Krauss et al., 2009, Krauss et al., 2009, McNeil et al., 2009, Mhlanga et al., 2009, Piccioni et al., 2009, Shyu et al., 2009, Snee and Macdonald, 2009, Tian and Deng, 2009, Boylan et al., 2008, Chia et al., 2008, Gervais et al., 2008, Li et al., 2008, Lin, 2008, Lin et al., 2008, Sousa-Nunes et al., 2008, Sung et al., 2008, Weil et al., 2008, Yu et al., 2008, Zimyanin et al., 2008, Barbosa et al., 2007, Coutelis and Ephrussi, 2007, Eulalio et al., 2007, Irion and St Johnston, 2007, Klusza and Deng, 2007, Meignin et al., 2007, Mische et al., 2007, Polesello and Tapon, 2007, Rusten and Stenmark, 2007, Slack et al., 2007, Weil et al., 2007, Zimyanin et al., 2007, Zimyanin et al., 2007, Barbee et al., 2006, Betschinger et al., 2006, Choksi et al., 2006, Denman, 2006, Doerflinger et al., 2006, Geng and Macdonald, 2006, Irion et al., 2006, Jenny et al., 2006, Kiebler and Bassell, 2006, Poulton and Deng, 2006, Shav-Tal and Singer, 2005)
              Stauffen
              (Dollar et al., 2002)
              staufen
              (Davis, 2015, Cheung et al., 2014, Morais-de-Sá et al., 2014, Laver et al., 2013, Miyashita et al., 2012, Winbush et al., 2012, Furman and Bukharina, 2011, Jambor et al., 2011, Loiseau et al., 2010, Weil et al., 2010, Besse et al., 2009, Kang et al., 2009, Spirov et al., 2009, Bolduc et al., 2008, He et al., 2008, Stark et al., 2007, Yucel and Small, 2006, Hall, 2003, Fuerstenberg et al., 1998)
              Secondary FlyBase IDs
                Datasets (1)
                Study focus (1)
                Experimental Role
                Project
                Project Type
                Title
                • transgene_used
                Stau_RIP_interaction_map
                Interaction map generated by purification of stau, with identificaiton of copurifying RNA transcripts by microarray.
                References (501)