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Gene Dmel\stau

General Information
Symbol	Dmel\stau	Species	D. melanogaster
Name	staufen	Annotation symbol	CG5753
Feature type	protein_coding_gene	FlyBase ID	FBgn0003520
Created / Updated	2003-12-01/2003-12-01
Genomic Location
Chromosome (arm)	2R	Recombination map	2-83.5
Cytogenetic map	55B5-55B7	Sequence location	2R:14,005,401..14,013,337 [-]
Map ( GBrowse )	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene staufen is referred to in FlyBase by the symbol stau (CG5753, FBgn0003520). It has the cytological map location 55B5-55B7. Its sequence location is 2R:14005401..14013337. Its molecular function is described as: mRNA 3'-UTR binding; microtubule binding; double-stranded RNA binding; mRNA binding. It is involved in the biological processes described with 19 unique terms, many of which group under: anterior/posterior axis specification; oocyte axis determination; oocyte anterior/posterior axis determination; cell fate commitment; pole plasm assembly; regulation of metabolic process; anatomical structure development; cellular macromolecule metabolic process; organelle organization and biogenesis; neuroblast fate commitment; positive regulation of cellular biosynthetic process; memory. 25 alleles are reported. The phenotypes of these alleles are annotated with 20 unique terms, many of which group under: embryonic abdomen; embryonic segment; embryonic tagma; anatomical structure; gastrula embryo; embryonic abdominal segment 4; egg; embryonic head; abdominal segment 7; blastoderm embryo; cell part. It has 2 annotated transcripts and 2 annotated polypeptides.
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	stau: staufen (T. Schupbach) Maternal-effect lethal. Embryos from homozygous mothers exhibit a so-called "grandchildless-knirps" phenotype; all eggs lack polar granules and no pole cells are formed; most embryos show variable deletions of abdominal segments, whereby segment A4 is deleted most frequently; larger deletions may delete segments A2 through A7; in extreme cases, anterior parts of segment A1 become fused to posterior parts of segment A8, but telson elements are always present and relatively normal. In addition, embryos show deletions of the anterior-most head structures and the cephalic furrow is shifted anteriorly at gastrulation. Analysis of germline clones indicates that the mutation is germline autonomous (Schupbach and Wieschaus, 1986, Dev. Biol. 113: 443-48).
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 55B5-55B7   Limits computationally determined from genome sequence between P{PZ}grh06850&P{lacW}olf186-Fk11505 and P{PZ}Hsf03091&P{EP}Dgp-1EP731
Experimentally Determined Cytological Location
Cytogenetic map Notes References 55A-55B (determined by in situ hybridisation)   (St. Johnston et al., 1991)
Experimentally Determined Recombination Data
Location	2-83.5 (Tearle and Nusslein-Volhard, 1987) 2-86 (Schupbach and Wieschaus, 1989)
Left of (cM)
Right of (cM)	c (Doane, 1999)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology) References In direction of increasing cytology: stau- Hsf- Pcl+ (Jedlicka et al., 1997) Gene Order (overall orientation not stated) References
Gene Model & Products
Please see the GBrowse view of Dmel\stau for information on other features
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) stau-RA FBtr0086783  NM_057403   5293   1026 stau-RB FBtr0086784  NM_166263   4898   914
Additional Transcript Data & Comments
Reported size (kB)	5.3 (northern blot) (St. Johnston et al., 1991)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kD) Length (aa) Theoretical pI RefSeq ID GenBank protein stau-PA   FBpp0085962   110.3   1026   9.63     NP_476751   AAF57752 stau-PB   FBpp0085963   98.0   914   9.51     NP_725748   AAF57753
Additional Polypeptide Data & Comments
Reported size (kD)	1026 (aa); 150 (kD observed) (St. Johnston et al., 1991)
Comments
External Data
Linkouts	PANTHER - Protein classification by function, families, and pathways • FBgn0003520
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Double-stranded RNA binding (IPR001159) Double-stranded RNA-binding-like (IPR014720) PDB - Protein Data Bank. An information portal to biological macromolecular structures • 1EKZ 1STU
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA246476   AA263692   AA263727   AA391245   AA391333   AA392961   AA438844   AA440970   AA538776   AA540227   AA540668   AA540765   AA803013   AA820187   AA941481   AA941542   AA979020   AC004336   AE003800 AAF57752   AE003800 AAF57753   AI113506   AI293283   AI293349   AI295203   AI519468   AI534077   AI947147   AW942263   BG639405   BI234307   BI242620   BI352319   BI366962   BI579149   BI585686   BI588991   BI612089   BI622362   BI631799   BP550282   BP550283   BQ102781   BQ103518   BT003228 AAO24983   BT010297 AAQ23615   CK658551   CO193397   CO265226   CO273247   CO275026   CO275923   CO277146   CO277862   CO279777   CO280657   CO281477   CO282505   CO286949   CO289175   CO298169   CO306792   CO308565   CO311310   CO317454   CO319355   CO320181   CO321878   CO333455   CO333731   CO335531   CO339401   CO340755   CZ489632   EC060470   EC061336   EC067628   EC070226   EC071484   EC073420   EC078366   EC083143   EC084811   EC089116   EC090755   EC195122   EC204954   EC206591   EC207417   EC208447   EC208879   EC208895   EC209916   EC213491   EC221116   EC227560   EC228366   EC229379   EC229647   EC233142   EC247924   EC251734   EC253380   EC259307   EC263143   EL883165   EL883166   M69111 AAA73062   Z32009
UniProtKB/Swiss-Prot	P25159
UniProtKB/TrEMBL
Maps to	DS03544 (FlyBase, 1992-)
Does NOT map to
Identified with	GH16566 bs35f05.y1 (Oliver, 2001.8.16) LD13210 LP08764 (BDGP Project Members, 2000-)
Mapped Features & Mutations
Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here Type Symbol & Location Additional Notes References rescue fragment stau[+t16.3] 2R:14,004,679..14,020,979 comment=Position of restriction fragment on reference sequence inferred by FlyBase curator. Downstream boundary of rescue fragment is approximate due to lack of SalI site at reported location in reference genomic sequence. evidence=experimental linked_to=SalI-END_rfrag (St. Johnston et al., 1991)
External Data
Linkouts	DEDB - Drosophila exon database: splicing graphs • 12029
Crossreferences
Expression Data
FlyBase-Curated Data
Transcript and Protein data	Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
Summary of Transcript Expression
Stage Tissue/Position Reference  oogenesis stage,adult stage | stage S6  oocyte | presumptive (St. Johnston et al., 1991)  oogenesis stage,adult stage | stage S6-S10  nurse cell (St. Johnston et al., 1991)  oogenesis stage,adult stage | stage S3-S4  female germline stem cell (St. Johnston et al., 1991)  embryonic stage | fertilized egg   (St. Johnston et al., 1991)
Marker for
Subcellular Localization
CV Term
Summary of Polypeptide Expression
Stage Tissue/Position Reference  embryonic stage | contracted germ band  central nervous system (St. Johnston et al., 1991)  oogenesis stage | stage S6-8  polar follicle cell (Xi et al., 2003)  oogenesis stage | stage S3-S4  oocyte | presumptive (St. Johnston et al., 1991)  embryonic stage | stage 1   (Ferrandon et al., 1994)  oogenesis stage,adult stage | stage >=S10B  nurse cell (St. Johnston et al., 1991)  embryonic stage | stage 1   (Ferrandon et al., 1994)  oogenesis stage,adult stage | stage S10  oocyte | posterior (Breitwieser et al., 1996)  embryonic stage | extended germ band stage  embryonic nervous system (St. Johnston et al., 1991)  embryonic stage | early   (St. Johnston et al., 1991)  embryonic stage | early  pole plasm (St. Johnston et al., 1991)  adult stage  > stage S11 oocyte | anterior (Martin et al., 2003)  embryo | early  embryo | posterior (Breitwieser et al., 1996)  embryonic stage | stage 1   (Ferrandon et al., 1994)  oogenesis stage,adult stage | stage S8-S10B  oocyte | posterior (St. Johnston et al., 1991)
Marker for
Subcellular Localization
CV Term	plasma membrane | apical & adjacent to cytoplasm | apical plasma membrane | basal & adjacent to (Broadus et al., 1998) plasma membrane | apical plasma membrane | basal centrosome (Schuldt et al., 1998) plasma membrane | apical plasma membrane | basal (Shen et al., 1998)
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003520 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • FBgn0003520 GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies • FBgn0003520 BDGP expression data • Show all BDGP original images, annotations and embryonic microarray data for stau FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for stau Stage(s) 1-3 Stage(s) 4-6 Stage(s) 9-10 Stage(s) 11-12 Stage(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | maternal effect stauunspecified lethal | maternal effect | recessive stau1 stau2 stau4 lethal | maternal effect | recessive | conditional - heat sensitive stau3 lethal | embryonic stage | maternal effect | recessive staury9 stauunspecified lethal | embryonic stage | germ-line clone | non-rescuable maternal effect | recessive stau2R-224-13 stau2R-3-30 stau2R-302-27 stau2R-46-15 stau2R-98-28 Other Phenotypes Allele wild-type stau+t16.3 stauΔN.αTub67C.T:Hsap\MYC stauαTub67C.T:Avic\GFP-m6 memory defective | conditional - heat sensitive (with stau2) stau3 memory defective | conditional - heat sensitive (with stau3) stau2 Sterility Allele female sterile | maternal effect stau1 stau2 female sterile | recessive stauunspecified male sterile | maternal effect stau1 stau2 grandchildless | recessive stauunspecified Phenotype manifest in Allele pole cell stau1 stau2 staudsRBD3mut stauunspecified abdominal segment stau1 embryonic head stau2 staudsRBD3mut embryonic abdomen stau2 staudsRBD3mut embryonic head | germ-line clone | maternal effect stau2R-224-13 stau2R-3-30 stau2R-302-27 stau2R-46-15 stau2R-98-28 embryo | germ-line clone | maternal effect | posterior stau2R-224-13 stau2R-3-30 stau2R-302-27 stau2R-46-15 stau2R-98-28 embryonic head | maternal effect staury9 embryonic abdomen | maternal effect staury9 pole granule | maternal effect stauunspecified pole cell | maternal effect stauunspecified embryonic abdominal segment | maternal effect stauunspecified cephalic furrow | maternal effect stauunspecified embryonic head | anterior | maternal effect stauunspecified pole plasm stauunspecified embryonic abdominal segment 1 stauunspecified embryonic abdominal segment 2 stauunspecified embryonic abdominal segment 3 stauunspecified embryonic abdominal segment 4 stauunspecified embryonic abdominal segment 5 stauunspecified embryonic abdominal segment 6 stauunspecified embryonic abdominal segment 7 stauunspecified embryonic abdominal segment 8 stauunspecified embryonic abdominal segment 9 stauunspecified embryonic abdominal segment 10 stauunspecified embryonic abdominal segment 11 stauunspecified embryonic head | anterior stauunspecified
Classical Alleles ( 15 )
For All Classical Alleles Show
Allele of stau Class Mutagen Stocks Known lesion stau1 hypomorph ethyl methanesulfonate 8 Yes stau2 loss of function ethyl methanesulfonate 0 Yes stau2R-224-13 ethyl methanesulfonate 0 -- stau2R-3-30 ethyl methanesulfonate 0 -- stau2R-302-27 ethyl methanesulfonate 0 -- stau2R-46-15 ethyl methanesulfonate 0 -- stau2R-98-28 ethyl methanesulfonate 0 -- stau3 hypomorph ethyl methanesulfonate 0 Yes stau4 hypomorph ethyl methanesulfonate 0 Yes stauCC8 0 -- stauRY 0 -- stauf06894 piggyBac transposase 1 -- staur9 0 -- staury9 loss of function P-element activity 1 Yes stauunspecified ethyl methanesulfonate 0 --
Alleles Carried on Transgenic Constructs ( 10 )
For All Alleles Carried on Transgenic Constructs Show
Allele of stau Class Mutagen Stocks Known lesion stau+t16.3 in vitro construct | genomic fragment 0 Yes stau17ΔN.T:Avic\GFP in vitro construct | coding region fusion 0 Yes stauGD11758</