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General Information
Symbol
Dmel\stau
Species
D. melanogaster
Name
staufen
Annotation Symbol
CG5753
Feature Type
FlyBase ID
FBgn0003520
Gene Model Status
Stock Availability
Gene Snapshot
staufen (stau) encodes a double-stranded RNA binding protein involved in mRNA localization. It contributes to anterior and posterior patterning, nervous system development and long term memory. [Date last reviewed: 2019-03-14]
Also Known As
dStau
Key Links
Genomic Location
Cytogenetic map
Sequence location
2R:18,117,896..18,125,779 [-]
Recombination map
2-84
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Protein Family (UniProt)
-
Summaries
Protein Function (UniProtKB)
RNA-binding protein which forms ribonucleoprotein complexes (RNPs) that play critical roles in the localization, translational repression and turnover of RNAs during embryogenesis, neurotransmission and neurogenesis (PubMed:10698941, PubMed:1712672, PubMed:8001156, PubMed:17178403). In the oocyte, essential for the localization of both the osk/oskar mRNA to the posterior pole and bcd/bicoid RNA to the anterior pole, and is therefore required for the correct anterior-posterior patterning of the developing embryo (PubMed:10698941, PubMed:1712672, PubMed:8001156). Association with osk or bcd at their respective poles, appears to promote the formation and stabilization of the ribonucleoprotein complexes (PubMed:1712672, PubMed:8001156). Integral component of diverse neuritic ribonucleoprotein complexes (RNPs) that mediate the transport, translation and turnover of neuronal RNAs during neuorgenesis and the translation repression of synaptic transcripts in preparation for their dendritic targeting (PubMed:17178403).
(UniProt, P25159)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
stau: staufen (T. Schupbach)
Maternal-effect lethal. Embryos from homozygous mothers exhibit a so-called "grandchildless-knirps" phenotype; all eggs lack polar granules and no pole cells are formed; most embryos show variable deletions of abdominal segments, whereby segment A4 is deleted most frequently; larger deletions may delete segments A2 through A7; in extreme cases, anterior parts of segment A1 become fused to posterior parts of segment A8, but telson elements are always present and relatively normal. In addition, embryos show deletions of the anterior-most head structures and the cephalic furrow is shifted anteriorly at gastrulation. Analysis of germline clones indicates that the mutation is germline autonomous (Schupbach and Wieschaus, 1986, Dev. Biol. 113: 443-48).
Summary (Interactive Fly)
Double stranded RNA binding protein - required for the localization of multiple mRNA species during oogenesis and zygotic development -direct binding of Staufen to and mRNAs is a requirement for their subcellular distribution - as a posterior group protein Staufen required for the localization of mRNA to the posterior pole of the oocyte
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
3

Please see the GBrowse view of Dmel\stau or the JBrowse view of Dmel\stau for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.50
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0086783
5240
1026
FBtr0086784
4910
914
FBtr0301614
3509
1025
Additional Transcript Data and Comments
Reported size (kB)
5.3 (northern blot)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0085962
110.3
1026
9.63
FBpp0085963
98.0
914
9.51
FBpp0290829
110.2
1025
9.63
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
1026 (aa); 150 (kD observed)
Comments
External Data
Subunit Structure (UniProtKB)
Component of neuronal ribonucleoprotein complexes (RNPs) that contains at least various translational repressor and mRNA turnover proteins such as me31B, tral, Upf1, AGO2 and sometimes Fmr1.
(UniProt, P25159)
Domain
Contains a proline-rich domain. The insertion of this domain in the DRBM 2 domain is required for stau-oskar mRNA localization. DRBM 3 domain binds optimally to stem-loops containing 12 bp (in vitro).
(UniProt, P25159)
Crossreferences
InterPro - A database of protein families, domains and functional sites
PDB - An information portal to biological macromolecular structures
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\stau using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (39 terms)
Molecular Function (6 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
inferred from direct assay
inferred from physical interaction with FLYBASE:mira; FB:FBgn0021776
inferred from direct assay
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
inferred from sequence or structural similarity
traceable author statement
non-traceable author statement
non-traceable author statement
Biological Process (20 terms)
Terms Based on Experimental Evidence (10 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (13 terms)
CV Term
Evidence
References
Cellular Component (13 terms)
Terms Based on Experimental Evidence (13 terms)
CV Term
Evidence
References
inferred from direct assay
inferred from direct assay
inferred from direct assay
inferred from direct assay
inferred from direct assay
inferred from direct assay
(assigned by BHF-UCL )
inferred from direct assay
(assigned by UniProt )
inferred from direct assay
(assigned by UniProt )
inferred from direct assay
(assigned by UniProt )
inferred from direct assay
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
non-traceable author statement
traceable author statement
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
organism

Comment: maternally deposited

antennal primordium

Comment: reported as procephalic ectoderm primordium

central brain primordium

Comment: reported as procephalic ectoderm primordium

visual primordium

Comment: reported as procephalic ectoderm primordium

dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

Additional Descriptive Data
stau is maternally expressed in the embryo and later expression is observed in a symmetric pattern along the ventral nerve cord.
stau transcript is first detected in germline cells at stage S3-S4 of oogenesis. By stage S6, stau expression is concentrated in the presumptive oocyte, but is also detected in the nurse cells. By stage S10, stau transcript is predominantly in the nurse cells, which later transfer their cytoplasm to the oocyte. Thus, stau transcript is uniformly distributed in the freshly laid egg. At cellularization, stau transcript is found in the basal regions of the blastoderm cells, and persists until after gastrulation.
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference
distribution deduced from reporter or direct label
Stage
Tissue/Position (including subcellular localization)
Reference
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic neuroblast

Comment: localized in a dense basal cresent as cells enter mitosis

embryonic neuroblast

Comment: localized in a diffuse apical cresent in mitotic cells

Additional Descriptive Data
stau protein localizes to the apical cortex of mitotic neuroblasts in late interphase and early prophase. It then localizes to the basal cortex in late prophase, metaphase, anaphase, and telophase. After mitosis, it segregates into the basal daughter cell.
stau protein is localized to the apical cortex and cytoplasm in late interphase neuroblasts. From metaphase through to telophase, stau protein is localized in a basal cortical crescent. At cytokinesis, it segregates into the daughter ganglion mother cell (GMC). stau protein localization is not microtubule-dependent.
A GFP-stau protein fusion was localized in live oocytes to the anterior region in the same position as the bcd transcript.
In a freshly laid fertilized embryo, stau protein is detected at the anterior and posterior poles. An unfertilized egg displays initial stau protein localization, which diffuses as the egg ages.
stau protein localizes to the apical side of neuroblasts at interphase. During prophase it forms a crescent on the basal side of the cell and remains there through the rest of mitosis. It partitions to the GMC when the cell divides. stau protein is often associated with the centrosome on the apical side of the neuroblast during anaphase. The carboxy-terminal 157 amino acids of stau are required for its localization to the cortex in neuroblasts.
In stage 10 oocytes, vas protein, osk protein, and stau protein colocalize at the posterior pole. In early embryos, vas protein and osk protein localize to the polar granules but stau protein does not colocalize with them. It is present in a thin crescent apposed closely to the posterior cortex and disappears before the pole cell stage. A GFP-Vas fusion protein was used to determine the vas protein distribution.
Marker for
 
Subcellular Localization
CV Term
Evidence
References
inferred from direct assay
inferred from direct assay
inferred from direct assay
inferred from direct assay
inferred from direct assay
inferred from direct assay
(assigned by BHF-UCL )
inferred from direct assay
(assigned by UniProt )
inferred from direct assay
(assigned by UniProt )
inferred from direct assay
(assigned by UniProt )
inferred from direct assay
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\stau in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 11-12
  • Stages(s) 13-16
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 18 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 23 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of stau
Transgenic constructs containing regulatory region of stau
Deletions and Duplications ( 24 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (4)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
11 of 15
Yes
Yes
11 of 15
Yes
Yes
1 of 15
No
No
1 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (5)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
10 of 15
Yes
Yes
8 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Rattus norvegicus (Norway rat) (5)
7 of 13
Yes
Yes
4 of 13
No
Yes
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (4)
8 of 12
Yes
Yes
5 of 12
No
Yes
1 of 12
No
No
1 of 12
No
No
Danio rerio (Zebrafish) (4)
11 of 15
Yes
Yes
11 of 15
Yes
Yes
1 of 15
No
No
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (1)
13 of 15
Yes
Yes
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091906QT )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150495 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W05H4 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X04V8 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G07A0 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (2)
2 of 10
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 3 )
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser

    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    RNA-protein
    Physical Interaction
    Assay
    References
    RNA-RNA
    Physical Interaction
    Assay
    References
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement

    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Subunit Structure (UniProtKB)
    Component of neuronal ribonucleoprotein complexes (RNPs) that contains at least various translational repressor and mRNA turnover proteins such as me31B, tral, Upf1, AGO2 and sometimes Fmr1.
    (UniProt, P25159 )
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Gene Group - Pathway Membership (FlyBase)
    External Data
    Linkouts
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    2R
    Recombination map
    2-84
    Cytogenetic map
    Sequence location
    2R:18,117,896..18,125,779 [-]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    55B5-55B7
    Limits computationally determined from genome sequence between P{PZ}grh06850&P{lacW}olf186-Fk11505 and P{PZ}Hsf03091&P{EP}Dgp-1EP731
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    55A-55B
    (determined by in situ hybridisation)
    Experimentally Determined Recombination Data
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (14)
    Genomic Clones (22)
    cDNA Clones (102)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequences
    BDGP DGC clones
    Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      Antibody Information
      Laboratory Generated Antibodies
      Commercially Available Antibodies
       
      Other Information
      Relationship to Other Genes
      Source for database identify of
      Source for identity of: stau CG5753
      Source for database merge of
      Additional comments
      Other Comments
      stau is required for localisation of cora mRNA and protein at the postsynaptic side of the neuromuscular junction.
      stau has a role in long-term memory.
      dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
      stau is not required for the cell fate decision in the NB6-4T lineage.
      Distinct domains of stau mediate microtubule and actin based MRNA transport.
      pros mRNA and the RNA-binding protein stau are asymmetrically localised in mitotic neuroblasts and are specifically partitioned into the GMC, as is pros protein. stau is required for localisation of pros RNA but not of pros protein. Loss of localisation of stau or of pros RNA alters GMC development, but only in embryos with reduced levels of pros protein, suggesting that pros RNA and pros protein act redundantly to specify GMC fate. GMCs do not transcribe the pros gene, showing that inheritance of pros RNA and/or pros proteins from the neuroblast is essential for GMC specification.
      mira function is required for asymmetrical localisation of stau protein.
      insc, pros and stau localisation in neuroblasts in vitro is studied. Extrinsic and intrinsic cues and microfilaments regulate the subcellular localisation of the pros, insc and stau proteins in neuroblasts.
      Binding of the bcd 3'UTR by stau protein requires a double stranded conformation of the stems within the bcd RNA localisation signal.
      insc and stau mediate asymmetric localization and segregation of pros RNA during neuroblast cell divisions. stau protein binds the pros RNA 3'UTR, via stau residues 565-661, which lie amino terminal to and distinct from the region of stau required to interact with the insc protein.
      osk, stau, vas and tud are essential for pole plasm formation. stau is required for both osk RNA localisation and translation.
      Mutants in chic resemble those in capu in that they fail to localize stau protein and osk mRNA to the posterior pole of the developing oocyte.
      Multinuclear/multidimensional NMR methods have been used to determine that the stau double stranded RNA binding domain (dsRBD) 3 forms a compact protein domain with an α-β-β-β-α structure. In vitro mutagenesis has identified F43 and T50 as two residues essential for RNA binding.
      Nurse cell-specific genes are functional in the pseudonurse cells of otu mutants, but the transport of pum, otu, ovo and bcd RNAs to the cytoplasm is affected.
      The stau product associates specifically with both osk and bcd mRNAs to mediate their localizations, but at two distinct stages of development. stau protein is required to anchor bcd mRNA at the anterior of the egg, and is transported with osk mRNA during oogenesis.
      Distribution of tud protein in mutant embryos has been studied.
      Comparison of bcd and hts transcript distribution in swa, exu and stau mutant embryos indicates different genetic requirements for proper localization of bcd and hts RNAs.
      The localization of the osk RNA and stau protein in oogenesis do not depend of the product of the psq locus.
      Only vas and tud are essential for osk-induced pole cell and abdomen formation, stau is not.
      vas, vls and tud (but not stau, capu, or spir) are necessary for the 6xosk mutant phenotypes.
      Deletion analysis and computer analysis identifies a 65 to 68 amino acid consensus sequence defining the minimal dsDNA binding domain.
      stau is required specifically for the localization of the posterior signal in the embryo, not the synthesis of the signal. BicD,stau embryos exhibit a duplication of the posterior telson at the anterior: the posterior signal can be active at the anterior independent of stau function. stau gene function is unique among maternal genes as it is required for both the accumulation of the anterior bcd-dependent signal and the posterior nos-dependent signal.
      Mutations in maternal posterior class gene stau do not interact with RpII140wimp.
      The posterior group gene stau is required both for the localization of maternal determinants to the posterior pole of the egg and for bcd RNA to localize correctly to the anterior pole. The stau product is one of the first molecules to localize to the posterior pole of the oocyte, perhaps in association with osk RNA. Once localized, stau product is found in the polar granules and is required to hold other polar granule components at the posterior pole. By the time the egg is laid, stau protein is also concentrated at the anterior pole, in the same region as bcd RNA.
      stau mutants exhibit deletion of the abdomen and pole plasm and anterior head defects.
      Mature follicles are immunologically stained for asymmetric distribution of ecdysteroid-related antigen. During late oogenesis localisation of the antigen changes dramatically suggesting the antigen plays a role in early embryogenesis and, perhaps, in pattern formation.
      In stau mutant females vas synthesis appears normal but the vas protein is not localized.
      stau plays a role in polar granule formation.
      Mutation in stau results in a maternal effect "grandchildless knirps-like" phenotype.
      stau mutations disrupt the fourth stage of bcd RNA localization during oogenesis: localization to a spherical region that occupies a slightly dorsal position of the anterior pole.
      Mutations in stau cause failure of germ cell formation and deletions in the abdominal segments in the embryo.
      Origin and Etymology
      Discoverer
      Etymology
      Identification
      External Crossreferences and Linkouts ( 50 )
      Sequence Crossreferences
      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
      UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
      Other crossreferences
      BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
      Flygut - An atlas of the Drosophila adult midgut
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
      InterPro - A database of protein families, domains and functional sites
      KEGG Genes - Molecular building blocks of life in the genomic space.
      modMine - A data warehouse for the modENCODE project
      PDB - An information portal to biological macromolecular structures
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      DRSC - Results frm RNAi screens
      FLIGHT - Cell culture data for RNAi and other high-throughput technologies
      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
      FlyMine - An integrated database for Drosophila genomics
      Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Synonyms and Secondary IDs (11)
      Reported As
      Symbol Synonym
      Name Synonyms
      Staufen
      (Baskar et al., 2019, Gáspár et al., 2017, Nieuwburg et al., 2017, Mahoney et al., 2016, Nashchekin et al., 2016, Gardiol and St Johnston, 2014, Gaspar et al., 2014, Ghosh et al., 2014, Leibfried et al., 2013, Timmerman et al., 2013, Jansen and Niessing, 2012, Kelsom and Lu, 2012, Ottone et al., 2012, Sanghavi et al., 2012, Parton et al., 2011, Poulton et al., 2011, Sun et al., 2011, Tanaka et al., 2011, van Eyk et al., 2011, Vazquez-Pianzola et al., 2011, Yan et al., 2011, Doerflinger et al., 2010, Gonsalvez et al., 2010, Hillebrand et al., 2010, Klusza and Deng, 2010, Krahn et al., 2010, Kim et al., 2009, Krauss et al., 2009, Krauss et al., 2009, McNeil et al., 2009, Mhlanga et al., 2009, Piccioni et al., 2009, Shyu et al., 2009, Snee and Macdonald, 2009, Tian and Deng, 2009, Boylan et al., 2008, Chia et al., 2008, Gervais et al., 2008, Li et al., 2008, Lin, 2008, Lin et al., 2008, Sousa-Nunes et al., 2008, Sung et al., 2008, Weil et al., 2008, Yu et al., 2008, Zimyanin et al., 2008, Barbosa et al., 2007, Coutelis and Ephrussi, 2007, Eulalio et al., 2007, Irion and St Johnston, 2007, Klusza and Deng, 2007, Meignin et al., 2007, Mische et al., 2007, Polesello and Tapon, 2007, Rusten and Stenmark, 2007, Slack et al., 2007, Weil et al., 2007, Zimyanin et al., 2007, Zimyanin et al., 2007, Barbee et al., 2006, Betschinger et al., 2006, Choksi et al., 2006, Denman, 2006, Doerflinger et al., 2006, Geng and Macdonald, 2006, Irion et al., 2006, Jenny et al., 2006, Kiebler and Bassell, 2006, Poulton and Deng, 2006, Shav-Tal and Singer, 2005)
      Secondary FlyBase IDs
        Datasets (1)
        Study focus (1)
        Experimental Role
        Project
        Project Type
        Title
        • transgene_used
        Interaction map generated by purification of stau, with identificaiton of copurifying RNA transcripts by microarray.
        References (503)