General Information
Symbol
Dmel\Ste
Species
D. melanogaster
Name
Stellate
Annotation Symbol
Feature Type
FlyBase ID
FBgn0003523
Gene Model Status
Stock Availability
GO Summary Ribbons
Families, Domains and Molecular Function
Gene Group Membership (FlyBase)
Protein Family (UniProt, Sequence Similarities)
Belongs to the casein kinase 2 subunit beta family. (Q7KV12)
Molecular Function (see GO section for details)
Experimental Evidence
Predictions / Assertions
Summaries
UniProt Contributed Function Data
Unknown. In males lacking the Y chromosome, its strong overexpression leads to the appearance of proteinaceous star-shaped crystals in the primary spermatocytes causing meiotic drive, possibly by interfering with normal casein kinase 2 activity.
(UniProt, Q7KV12)
Phenotypic Description from the Red Book (Lindsley and Zimm 1992)
Ste: Stellate
This locus is responsible for the appearance of crystals in the nuclei and cytoplasm of primary spermatocytes of XO males. Enzymatic treatments indicate that these crystals are proteinaceous in nature (Meyer et al.). The suppression of crystal formation by the Y chromosome is attributable to a sequence designated Su(Ste).
Gene Model and Products
Number of Transcripts
0
Number of Unique Polypeptides
0

Please see the GBrowse view of Dmel\Ste or the JBrowse view of Dmel\Ste for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Polypeptides with Identical Sequences

 

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)
Interacts in vitro with the casein kinase 2 alpha subunit (CkII-alpha). The relevance of such interaction is however unclear in vivo.
(UniProt, Q7KV12)
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ste using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Gene Ontology (6 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
inferred from sequence or structural similarity
Biological Process (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
traceable author statement
Cellular Component (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (0 terms)
Expression Data
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Ste transcript is detected in the nuclei of early and mature primary spermatocytes. In early spermatocytes, Ste transcript has a diffuse nuclear localization, while in mature spermatocytes, transcript is observed in one or two bright discrete dots. The antisense probe does not distinguish between Ste and Su(Ste) transcripts.
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Ste in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
Images
Alleles, Insertions, Transgenic Constructs and Phenotypes
Classical and Insertion Alleles ( 5 )
For All Classical and Insertion Alleles Show
 
Allele of Ste
Class
Mutagen
Associated Insertion
Stocks
Known lesion
Other relevant insertions
insertion of mobile activating element
Name
Expression Data
Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Ste
Allele of Ste
Mutagen
Associated Transgenic Construct
Stocks
Transgenic constructs containing regulatory region of Ste
reporter construct
Deletions and Duplications ( 2 )
Summary of Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Phenotype manifest in
Allele
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (0)
No orthologs reported.
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (0)
No orthologs reported.
Rattus norvegicus (Norway rat) (0)
No orthologs reported.
Xenopus tropicalis (Western clawed frog) (0)
No orthologs reported.
Danio rerio (Zebrafish) (0)
No orthologs reported.
Caenorhabditis elegans (Nematode, roundworm) (0)
No orthologs reported.
Arabidopsis thaliana (thale-cress) (0)
No orthologs reported.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No orthologs reported.
Schizosaccharomyces pombe (Fission yeast) (0)
No orthologs reported.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( None identified )
No orthologies identified
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( None identified )
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( None identified )
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( None identified )
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
No non-Arthropod Metazoa orthologies identified
Human Disease Model Data
FlyBase Human Disease Model Reports
    Alleles Reported to Model Human Disease (Disease Ontology)
    Download
    Models ( 0 )
    Allele
    Disease
    Evidence
    References
    Interactions ( 0 )
    Allele
    Disease
    Interaction
    References
    Comments ( 0 )
     
    Human Orthologs (via DIOPT v7.1)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
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    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser

    Please look at the Interaction Group reports for full details of the physical interactions
    protein-protein
    Interacting group
    Assay
    References
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement

    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Subunit Structure (UniProtKB)
    Interacts in vitro with the casein kinase 2 alpha subunit (CkII-alpha). The relevance of such interaction is however unclear in vivo.
    (UniProt, Q7KV12 )
    Linkouts
    DroID - A comprehensive database of gene and protein interactions.
    Pathways
    Gene Group - Pathway Membership (FlyBase)
    External Data
    Linkouts
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    Recombination map
    1-45.7
    Cytogenetic map
    Sequence location
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    12E1-12E2
    Left limit from inclusion within Df(1)R12.1 (FBrf0079138) Right limit from in situ hybridisation (FBrf0079138)
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    12E1-12E2
    (determined by in situ hybridisation)
    12D1-12F2
    (determined by in situ hybridisation)
    Experimentally Determined Recombination Data
    Location
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (5)
    Genomic Clones (0)
     
      cDNA Clones (0)
       

      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

      cDNA clones, fully sequences
      BDGP DGC clones
        Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

            cDNA Clones, End Sequenced (ESTs)
            BDGP DGC clones
              Other clones
                RNAi and Array Information
                Linkouts
                Antibody Information
                Laboratory Generated Antibodies
                 
                Commercially Available Antibodies
                 
                Other Information
                Relationship to Other Genes
                Source for database identify of
                Source for database merge of
                Source for merge of: Ste BcDNA:GM31840
                Additional comments
                Annotation CG32605 split into 12 annotations, each representing a member of the Ste cluster, in release 3.2 of the genome annotation. The 12 annotations are: Ste:CG33236, Ste:CG33237, Ste:CG33238, Ste:CG33239, Ste:CG33240, Ste:CG33241, Ste:CG33242, Ste:CG33243, Ste:CG33244, Ste:CG33245, Ste:CG33246 and Ste:CG33247.
                Other Comments
                Extrachromosomal circular DNA (eccDNA) is present throughout the fly's life cycle. The eccDNA population contains circular multimers of tandemly repeated genes, including Ste.
                "Stellate-like" sequences (Ste, Su(Ste), SteXh and Ste12DOR) contain a common region of sequence, defined as the "Stellate-specific central core". Specific regions at either the 5' or 3' end of this core sequence distinguish different Stellate-like sequences from each other. Euchromatic Ste sequences all contain at their 5' end a region corresponding to the 3' end of the ben gene.
                Ste-/Su(Ste)- males have exactly the same meiotic drive phenotype as Ste+/Su(Ste)- males.
                The high extent of homology between Ste and Su(Ste) repeats suggested a possibility of Ste suppression by antisense transcription of Su(Ste) elements: however the detection of only "sense" Su(Ste) cDNAs in testis cDNA library argues against this proposal.
                One of a class of genes with TATA-less promoters that have a subset of the conserved DPE sequence.
                The relationship of Ste copy number and organisation to meiotic behaviour in Su(Ste)- males has been examined genetically and cytologically. Heterochromatic and euchromatic Ste repeats are functional, the abnormalities in chromosome condensation and frequency of nondisjunction is related to the Ste copy number. Meiosis is disrupted after synapsis and Su(Ste) induced meiotic drive is probably not mediated by Ste.
                The Ste locus contains two major size classes of a tandemly repeated gene. Analysis using segmental Y deficiencies shows that Su(Ste) represses both the high levels and efficient splicing of Ste RNA.
                "1-45.7" was stated as revision.
                This locus is responsible for the appearance of crystals in the nuclei and cytoplasm of primary spermatocytes of X0 males. Enzymatic treatments indicate that these crystals are proteinaceous in nature (Meyer, Hess and Beermann, 1961). The suppression of crystal formation by the Y chromosome is attributable to a sequence designated Su(Ste).
                Origin and Etymology
                Discoverer
                Etymology
                Identification
                External Crossreferences and Linkouts ( 12 )
                Crossreferences
                GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                Other crossreferences
                Linkouts
                DroID - A comprehensive database of gene and protein interactions.
                FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                Synonyms and Secondary IDs (11)
                Datasets (0)
                Study focus (0)
                Experimental Role
                Project
                Project Type
                Title
                References (143)