Interacts in vitro with the casein kinase 2 alpha subunit (CkII-alpha). The relevance of such interaction is however unclear in vivo.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ste using the Feature Mapper tool.
Ste transcript is detected in the nuclei of early and mature primary spermatocytes. In early spermatocytes, Ste transcript has a diffuse nuclear localization, while in mature spermatocytes, transcript is observed in one or two bright discrete dots. The antisense probe does not distinguish between Ste and Su(Ste) transcripts.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Ste in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: Ste BcDNA:GM31840
Annotation CG32605 split into 12 annotations, each representing a member of the Ste cluster, in release 3.2 of the genome annotation. The 12 annotations are: Ste:CG33236, Ste:CG33237, Ste:CG33238, Ste:CG33239, Ste:CG33240, Ste:CG33241, Ste:CG33242, Ste:CG33243, Ste:CG33244, Ste:CG33245, Ste:CG33246 and Ste:CG33247.
Extrachromosomal circular DNA (eccDNA) is present throughout the fly's life cycle. The eccDNA population contains circular multimers of tandemly repeated genes, including Ste.
"Stellate-like" sequences (Ste, Su(Ste), SteXh and Ste12DOR) contain a common region of sequence, defined as the "Stellate-specific central core". Specific regions at either the 5' or 3' end of this core sequence distinguish different Stellate-like sequences from each other. Euchromatic Ste sequences all contain at their 5' end a region corresponding to the 3' end of the ben gene.
The high extent of homology between Ste and Su(Ste) repeats suggested a possibility of Ste suppression by antisense transcription of Su(Ste) elements: however the detection of only "sense" Su(Ste) cDNAs in testis cDNA library argues against this proposal.
One of a class of genes with TATA-less promoters that have a subset of the conserved DPE sequence.
The relationship of Ste copy number and organisation to meiotic behaviour in Su(Ste)- males has been examined genetically and cytologically. Heterochromatic and euchromatic Ste repeats are functional, the abnormalities in chromosome condensation and frequency of nondisjunction is related to the Ste copy number. Meiosis is disrupted after synapsis and Su(Ste) induced meiotic drive is probably not mediated by Ste.
"1-45.7" was stated as revision.
This locus is responsible for the appearance of crystals in the nuclei and cytoplasm of primary spermatocytes of X0 males. Enzymatic treatments indicate that these crystals are proteinaceous in nature (Meyer, Hess and Beermann, 1961). The suppression of crystal formation by the Y chromosome is attributable to a sequence designated Su(Ste).