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General Information
Symbol
Dmel\Ste
Species
D. melanogaster
Name
Stellate
Annotation Symbol
Feature Type
FlyBase ID
FBgn0003523
Gene Model Status
Stock Availability
Gene Summary
Unknown. In males lacking the Y chromosome, its strong overexpression leads to the appearance of proteinaceous star-shaped crystals in the primary spermatocytes causing meiotic drive, possibly by interfering with normal casein kinase 2 activity. (UniProt, Q7KV12)
Contribute a Gene Snapshot for this gene.
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (6 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
inferred from mutant phenotype
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
inferred from sequence or structural similarity
Biological Process (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
involved_in spermatogenesis
inferred from genetic interaction with FLYBASE:Su(Ste); FB:FBgn0003582
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in spermatogenesis
traceable author statement
Cellular Component (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
located_in cytoplasm
inferred from direct assay
located_in nucleus
inferred from direct assay
inferred from direct assay
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the casein kinase 2 subunit beta family. (Q7KV12)
Summaries
Protein Function (UniProtKB)
Unknown. In males lacking the Y chromosome, its strong overexpression leads to the appearance of proteinaceous star-shaped crystals in the primary spermatocytes causing meiotic drive, possibly by interfering with normal casein kinase 2 activity.
(UniProt, Q7KV12)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
Ste: Stellate
This locus is responsible for the appearance of crystals in the nuclei and cytoplasm of primary spermatocytes of XO males. Enzymatic treatments indicate that these crystals are proteinaceous in nature (Meyer et al.). The suppression of crystal formation by the Y chromosome is attributable to a sequence designated Su(Ste).
Gene Model and Products
Number of Transcripts
0
Number of Unique Polypeptides
0
Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Polypeptides with Identical Sequences

 

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Interacts in vitro with the casein kinase 2 alpha subunit (CkII-alpha). The relevance of such interaction is however unclear in vivo.

(UniProt, Q7KV12)
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ste using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data

Ste transcript is detected in the nuclei of early and mature primary spermatocytes. In early spermatocytes, Ste transcript has a diffuse nuclear localization, while in mature spermatocytes, transcript is observed in one or two bright discrete dots. The antisense probe does not distinguish between Ste and Su(Ste) transcripts.

Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cytoplasm
inferred from direct assay
located_in nucleus
inferred from direct assay
inferred from direct assay
Expression Deduced from Reporters
Reporter: P{Ste-lacZ.134}
Stage
Tissue/Position (including subcellular localization)
Reference
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Ste in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 5 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Ste
Transgenic constructs containing regulatory region of Ste
Aberrations (Deficiencies and Duplications) ( 2 )
Inferred from experimentation ( 2 )
Gene disrupted in
Inferred from location ( 0 )
    Alleles Representing Disease-Implicated Variants
    Phenotypes
    For more details about a specific phenotype click on the relevant allele symbol.
    Lethality
    Allele
    Sterility
    Allele
    Phenotype manifest in
    Allele
    Orthologs
    Human Orthologs (via DIOPT v8.0)
    Homo sapiens (Human) (0)
    No records found.
    Model Organism Orthologs (via DIOPT v8.0)
    Mus musculus (laboratory mouse) (0)
    No records found.
    Rattus norvegicus (Norway rat) (0)
    No records found.
    Xenopus tropicalis (Western clawed frog) (0)
    No records found.
    Danio rerio (Zebrafish) (0)
    No records found.
    Caenorhabditis elegans (Nematode, roundworm) (0)
    No records found.
    Arabidopsis thaliana (thale-cress) (0)
    No records found.
    Saccharomyces cerevisiae (Brewer's yeast) (0)
    No records found.
    Schizosaccharomyces pombe (Fission yeast) (0)
    No records found.
    Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( None identified )
    No orthologies identified
    Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( None identified )
    No non-Drosophilid orthologies identified
    Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( None identified )
    No non-Dipteran orthologies identified
    Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( None identified )
    No non-Insect Arthropod orthologies identified
    Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
    No non-Arthropod Metazoa orthologies identified
    Paralogs
    Paralogs (via DIOPT v8.0)
    Drosophila melanogaster (Fruit fly) (0)
    No records found.
    Human Disease Associations
    FlyBase Human Disease Model Reports
      Disease Model Summary Ribbon
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Allele
      Disease
      Evidence
      References
      Potential Models Based on Orthology ( 0 )
      Human Ortholog
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Allele
      Disease
      Interaction
      References
      Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
      Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
      Homo sapiens (Human)
      Gene name
      Score
      OMIM
      OMIM Phenotype
      DO term
      Complementation?
      Transgene?
      Functional Complementation Data
      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
      Interactions
      Summary of Physical Interactions
      esyN Network Diagram
      Show neighbor-neighbor interactions:
      Select Layout:
      Legend:
      Protein
      RNA
      Selected Interactor(s)
      Interactions Browser

      Please see the Physical Interaction reports below for full details
      protein-protein
      Physical Interaction
      Assay
      References
      Summary of Genetic Interactions
      esyN Network Diagram
      esyN Network Key:
      Suppression
      Enhancement

      Please look at the allele data for full details of the genetic interactions
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      External Data
      Subunit Structure (UniProtKB)
      Interacts in vitro with the casein kinase 2 alpha subunit (CkII-alpha). The relevance of such interaction is however unclear in vivo.
      (UniProt, Q7KV12 )
      Linkouts
      DroID - A comprehensive database of gene and protein interactions.
      Pathways
      Signaling Pathways (FlyBase)
      Metabolic Pathways
      External Data
      Linkouts
      Genomic Location and Detailed Mapping Data
      Chromosome (arm)
      Recombination map
      1-45.7
      Cytogenetic map
      Sequence location
      FlyBase Computed Cytological Location
      Cytogenetic map
      Evidence for location
      12E1-12E2
      Left limit from inclusion within Df(1)R12.1 (FBrf0079138) Right limit from in situ hybridisation (FBrf0079138)
      Experimentally Determined Cytological Location
      Cytogenetic map
      Notes
      References
      12E1-12E2
      (determined by in situ hybridisation)
      12D1-12F2
      (determined by in situ hybridisation)
      Experimentally Determined Recombination Data
      Location
      Left of (cM)
      Right of (cM)
      Notes
      Stocks and Reagents
      Stocks (4)
      Genomic Clones (0)
       
        cDNA Clones (0)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
          Other clones
            Drosophila Genomics Resource Center cDNA clones

            For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

              cDNA Clones, End Sequenced (ESTs)
              BDGP DGC clones
                Other clones
                  RNAi and Array Information
                  Linkouts
                  Antibody Information
                  Laboratory Generated Antibodies
                   
                  Commercially Available Antibodies
                   
                  Other Information
                  Relationship to Other Genes
                  Source for database identify of
                  Source for database merge of

                  Source for merge of: Ste BcDNA:GM31840

                  Additional comments

                  Annotation CG32605 split into 12 annotations, each representing a member of the Ste cluster, in release 3.2 of the genome annotation. The 12 annotations are: Ste:CG33236, Ste:CG33237, Ste:CG33238, Ste:CG33239, Ste:CG33240, Ste:CG33241, Ste:CG33242, Ste:CG33243, Ste:CG33244, Ste:CG33245, Ste:CG33246 and Ste:CG33247.

                  Other Comments

                  Extrachromosomal circular DNA (eccDNA) is present throughout the fly's life cycle. The eccDNA population contains circular multimers of tandemly repeated genes, including Ste.

                  "Stellate-like" sequences (Ste, Su(Ste), SteXh and Ste12DOR) contain a common region of sequence, defined as the "Stellate-specific central core". Specific regions at either the 5' or 3' end of this core sequence distinguish different Stellate-like sequences from each other. Euchromatic Ste sequences all contain at their 5' end a region corresponding to the 3' end of the ben gene.

                  Ste-/Su(Ste)- males have exactly the same meiotic drive phenotype as Ste+/Su(Ste)- males.

                  The high extent of homology between Ste and Su(Ste) repeats suggested a possibility of Ste suppression by antisense transcription of Su(Ste) elements: however the detection of only "sense" Su(Ste) cDNAs in testis cDNA library argues against this proposal.

                  One of a class of genes with TATA-less promoters that have a subset of the conserved DPE sequence.

                  The relationship of Ste copy number and organisation to meiotic behaviour in Su(Ste)- males has been examined genetically and cytologically. Heterochromatic and euchromatic Ste repeats are functional, the abnormalities in chromosome condensation and frequency of nondisjunction is related to the Ste copy number. Meiosis is disrupted after synapsis and Su(Ste) induced meiotic drive is probably not mediated by Ste.

                  The Ste locus contains two major size classes of a tandemly repeated gene. Analysis using segmental Y deficiencies shows that Su(Ste) represses both the high levels and efficient splicing of Ste RNA.

                  "1-45.7" was stated as revision.

                  This locus is responsible for the appearance of crystals in the nuclei and cytoplasm of primary spermatocytes of X0 males. Enzymatic treatments indicate that these crystals are proteinaceous in nature (Meyer, Hess and Beermann, 1961). The suppression of crystal formation by the Y chromosome is attributable to a sequence designated Su(Ste).

                  Origin and Etymology
                  Discoverer
                  Etymology
                  Identification
                  External Crossreferences and Linkouts ( 12 )
                  Sequence Crossreferences
                  GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                  GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                  UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                  UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                  Other crossreferences
                  Linkouts
                  DroID - A comprehensive database of gene and protein interactions.
                  FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                  Synonyms and Secondary IDs (11)
                  Reported As
                  Secondary FlyBase IDs
                  • FBgn0063181
                  Datasets (0)
                  Study focus (0)
                  Experimental Role
                  Project
                  Project Type
                  Title
                  References (149)