Dub, mei-1794, Double or nothing, Mklp2
kinesin-6 homolog - bundles antiparallel microtubules - required for cytokinesis in mitosis and spindle organization and chromosome segregation in female meiosis
Please see the JBrowse view of Dmel\sub for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.50
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\sub using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signals
View Dmel\sub in GBrowse 22-84
2-86.8
2-82.6
Mapping based on 33 recombinants.
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: mei-1794 CG12298
Source for merge of: sub Dub mei-1794
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in S2R+ cells: cell morphology is aberrant and there is an increased frequency of microtubule-based mitotic spindles, indicative of a failure in mitosis. This phenotype is not seen in Kc167 cells.
Identification: genetic screen for meiotic mutants.
Required for spindle assembly during meiosis, and specifically, the formation of the two spindle poles.
Mutants show defective meiosis.
Mutations of sub primarily affect the homolog segregation during the first meiotic division of both males and females (FBrf0073960).
sub is unusual in that mutations cause aberrant chromosome segregation almost exclusively in meiosis I in both sexes.
Mutations in sub show a strict maternal effect phenotype with defects in fertilisation or early embryonic development.