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General Information
Symbol
Dmel\su(f)
Species
D. melanogaster
Name
suppressor of forked
Annotation Symbol
CG17170
Feature Type
FlyBase ID
FBgn0003559
Gene Model Status
Stock Availability
Gene Summary
suppressor of forked (su(f)) is an essential gene that encodes a protein involved in mRNA 3'-end processing (the nuclear cleavage/polyadenylation reaction) and alternative poly(A) site utilization. su(f) product accumulates in dividing cells where it is required for mitosis progression. [Date last reviewed: 2019-09-26] (FlyBase Gene Snapshot)
Also Known As

su-f, CstF77, l(1)R-9-18, R9-18, l(1)su(f)

Key Links
Genomic Location
Cytogenetic map
Sequence location
X:23,096,771..23,101,431 [+]
Recombination map
1-66
RefSeq locus
NC_004354 REGION:23096771..23101431
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (6 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables mRNA binding
inferred from biological aspect of ancestor with PANTHER:PTN000463331
(assigned by GO_Central )
Biological Process (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in mRNA processing
inferred from electronic annotation with InterPro:IPR008847
(assigned by InterPro )
inferred from biological aspect of ancestor with PANTHER:PTN000463331
(assigned by GO_Central )
Cellular Component (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000463331
(assigned by GO_Central )
Protein Family (UniProt)
-
Summaries
Gene Snapshot
suppressor of forked (su(f)) is an essential gene that encodes a protein involved in mRNA 3'-end processing (the nuclear cleavage/polyadenylation reaction) and alternative poly(A) site utilization. su(f) product accumulates in dividing cells where it is required for mitosis progression. [Date last reviewed: 2019-09-26]
Gene Group (FlyBase)
HISTONE PRE-MRNA CLEAVAGE COMPLEX -
Histone cleavage complex includes endonucleases and polyadenylation factors involved in processing of histone pre-mRNA. (Adapted from FBrf0223323 and PMID:23071092).
POLYADENYLATION FACTORS -
Polyadenylation factors associate with snRNPs, cleavage complexes and other factors to mediate the 3' end processing of pre-mRNA. (Adapted from FBrf0223323).
Protein Function (UniProtKB)
Essential protein, may play a role in mRNA production or stability.
(UniProt, P25991)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
su(f): suppressor of forked
su(f) mutations are found with several levels of reduced expression, and some if not all mutant alleles are sensitive to temperature. The weakest exhibit no phenotype when raised at 25 other than modification of the expression of specific alleles at other loci; increasingly reduced expression leads to a specific phenotype, which variably includes Minute-like bristles, rough eyes with some anterior indentation, reduced or absent ocelli, missing ocellar and other head and thoracic bristles, irregular acrostichal rows, excessive melanization, especially on head, and some crippling of legs; also wings may be blistery, broader, with extra veins and may be held upward and outward (Grell, CP627; Schalet, 1968, DIS 44: 125). The most severely affected alleles are lethal, the lethal period becoming earlier with increasing severity. At least one instance of interallelic complementation has been reported by an allele which in surviving adults exhibits pale yellow thread-like chaetae. Viable alleles act as allele-specific but locus-nonspecific modifiers. The locus was recognized by the nearly wild-type bristle phenotype of f su(f); some bristles slightly shortened or twisted at tips. Autonomous in gynandromorphs. f alleles fall into two classes: suppressible (f1, f4, and f5) and insuppressible (f3 and f3N)(Green, 1959, Heredity 13: 303-15). Suppressible alleles are spontaneous and contain insertions of transposable sequences; such alleles are also frequently modified by mutations in other modifier genes. For example, among alleles with gypsy inserts, su(f) suppresses ctk, lz1, f1, f5, bx34e, but not y2, Hw1, sc1, or ct6; all are suppressed by su(Hw). In addition, su(f) enhances the spontaneous mutants wa (copia) and lz37, but not we, lz34, lzk, s1, or v1 (412); all of these are affected by one or more other suppressor genotypes (Rutledge, Mortin, Schwarz, Thierry-Mieg, and Meselson, 1988, Genetics 119: 391-97). Does not suppress the effect of f on the phenotype of dvr, i.e. crumpled wings (Lee, 1974, Aust. J. Biol. Sci. 27: 305-7).
su(f)1
Wild type in appearance with normal viability and fertility when raised at 25; however, both su(f) flies raised at 29-30 and su(f)/Df(1)su(f) flies raised at 25 display the Minute-like syndrome. The same phenotype is seen in combinations with su(f)2 and su(f)6 raised at 29. su(f)/Df(1)su(f) is lethal when raised at 29; viability also temperature sensitive in combination with su(f)3 and su(f)5 (Schalet and Lefevre, 1976). su(f) enhances wa; wa su(f) eyes nearly white at 25 and white at 18 but apricot in flies raised at 29; suppresses lz1 and enhances lz37 at all temperatures. Increases the accumulation of gypsy transcript, suggesting that the wild-type allele represses gypsy (Parkhurst and Corces, 1986, Mol. Cell. Biol. 6: 2271-74); protein binding to a negative regulatory sequence of gypsy is reduced in nuclear extracts from su(f) pupae compared with those from wild type, again suggesting gypsy repression by su(f)+ (Mazo, Mizrokhi, Karavanov, Sedkov, Krichevskaha, and Ilyn, 1989, EMBO J. 8: 903-11).
su(f)2
Homozygotes lethal at the larval stage; homozygous germ-line clones don't survive; no effect on development of peripheral or central nervous systems (Perrimon, Smouse, and Miklos, 1989, Genetics 121: 313-31). Survives and suppresses f in combination with su(f)1 at 25, and exhibits M-like syndrome in flies raised at 18. wa displays dilute apricot pigmentation in su(f)1/su(f)2 flies raised at 25 but white eyes when raised at 18 (Schalet and Lefevre, 1976). su(f)2 shown to be proximal to su(f)1 by recombination (Schalet).
su(f)3
Homozygous lethal. Fails to complement lethality of either su(f)3 or su(f)5. In combination with su(f)1 shows the M-like syndrome at 25 and is lethal at 29.
su(f)4
May be the only pale-bristle allele. One other allele of this type was found by Dale Grace as a sex-lined lethal (Schalet). Recovered originally as a sex-linked recessive lethal, but fully viable, though weak, and suppresses f when raised at 18. Survivors exhibit pale-yellow, thread-like bristles, darker pigmentation dorsoanteriorly on thorax, and curled or wrinkled wings. Lethality at late pupal stage; homozygous germ-line clones show no maternal effect; also, no zygotic effects on development of peripheral or central nervous systems (Perrimon, Smouse, and Miklos, 1989, Genetics 121: 313-31). Interactions of su(f)4 with other su(f) alleles are as follows: su(f)1, same as su(f)1 homozygotes at all temperatures; su(f)2, complementation for viability and bristle color and slight complementation for suppression of f; su(f)3, lethal at the time of puparium formation at 25, fully viable with some chaetae of all individuals showing the pale-bristle phenotype and the texture of the wings appearing abnormal at 18; su(f)5, fully viable and normal at 18, variable viability with a broad streak of dark pigment on thorax, which sometimes is concentrated at dorsal anterior region, and wings which may extend upward and outward at 25, lethal prior to puparium formation at 29; su(f)6, fully viable and normal at 18 and 25 but exhibiting the M-like syndrome at 29; Df(1)su(f), lethal at the time of puparium formation at 25 and just prior to eclosion at 18. Enhances wa; wa su(f) eyes white in flies raised at 25 and dilute apricot at 18; also enhances lz37 at 18.
su(f)6
Homozygotes lethal at the larval stage; homozygous germ-line clones don't survive; no effect on development of peripheral or central nervous systems (Perrimon, Smouse, and Miklos, 1989, Genetics 121: 313-31). Lethal with su(f)3 at 25 and with su(f)4 at 29. In combination with su(f)1, displays the M-like syndrome at 25 and lethal at 29.
su(f)8
The first allele recovered specifically as a temperature-sensitive lethal; completely lethal at 29; suppresses f at 25 but not at 18. Temperature-sensitive period for lethality from 50 to 140 h after oviposition, for f suppression coincident with bristle differentiation. Shift up to 30 before end of the second instar causes failure to pupariate; full-sized third instar larvae produced, which live 10-14 days; salivary-gland-secretion proteins specifically reduced or absent in these larvae, although the associated chromosome puffs appear normally; other proteins unaffected (Hansson, Lineruth, and Lambertsson, 1982, Wilhelm Roux's Arch. Dev. Biol. 190: 308-12); shift up prior to 70 h leads to little or no accumulation of Sgs transcripts as detected in Northern blots probed with sequences from Sgs3, Sgs4, Sgs7, and Sgs8, whereas a 48-h pulse beginning at 75 h is without effect on transcription or translation of Sgs genes (Hansson and Lambertsson, 1983, Mol. Gen. Genet. 192: 395-40). Shift up to 30 in early third instar blocks the increase in ecdysterone titer normally occurring at the end of L3; ecdysterone supplementation induces abortive pupariation and stimulates prepupal polypeptide synthesis (Hansson and Lambertsson, 1984, Wilhelm Roux's Arch. Dev. Biol. 193: 48-51); leg discs of such larvae unable to evert, either in vivo or in vitro (Fekete and Lambertsson, 1980, Hereditas 93: 169-76). Homozygous females raised under permissive conditions, when shifted up to 30 cease laying eggs and the ovarian oocytes degenerate; fertility recoverable after pulses of three but not eleven hours (Dudick et al.). Heterozygotes with Df(1)su(f) at 25, su(f)1 at 29, and su(f)3 at 30 exhibit the M-like syndrome. Enhances M(3)67C, as indicated by reduced viability of su(f)8 versus su(f)+ sibs that are M(3)67C/+ (Girton, Langner, and Cejka, 1986, Roux's Arch. Dev. Biol. 195: 334-37). Enhances gypsy expression, more at 25 than at 18 (Parkhurst and Corces, 1986, Mol. Cell. Biol. 6: 2271-74).
su(f)9
Recovered as a surviving son of su(f)3; still suppresses f, but is no longer lethal. X/Y males survive and have small rough eyes, broad outstretched wings and irregular abdominal pigmentation; homozygous females usually lethal with escapers showing the same phenotype as the males. XXY females survive and resemble XY males. X0 males die. su(f)9/su(f)3 never survives. Attributed by authors to a recessive variegated-position-effect suppressor of the lethality of su(f)3; locates to proximal extremity of the X; complements bb.
su(f)12
Selected as a cell-autonomous, temperature-sensitive lethal. Relative survival is 85% at 22, 75% at 25 and 1% at 29; temperature-sensitive period from first larval instar to early pupa. Homozygous females become sterile after two days at 29, whereas males so treated remain fertile. 23% of eggs laid at 29 fail to hatch; surviving larvae grow at subnormal rate and survive for up to twelve days, reaching the third instar; imaginal discs reduced greatly in size. 48-h pulses of 30 during late second and third instars results in considerable cell death in imaginal discs with a consequent deletion of some pattern elements and duplications of others in the head and legs; head duplications occur only in association with deficiencies; leg duplications seen as simply and complexly branched appendages involving variable numbers of joints. Pulses applied to early pupae lead to failure of histoblast differentiation and applied later to the lack of chaetae (Russell, Girton, and Morgan, 1977, Wilhelm Roux's Arch. Dev. Biol. 183: 41-59). Extensive use made of leg duplications induced in su(f)12 in investigations of pattern formation (Tiong, Girton, Hayes, and Russell, 1977, Nature 268: 435-37; Postlethwait, 1978, Wilhelm Roux's Arch. Dev. Biol. 185: 37-57; Girton and Russell, 1980, Dev. Biol. 77: 1-21; Girton, 1981, Dev. Biol. 84: 164-72; Girton and Russell, 1981, Dev. Biol. 85: 55-64). Enhances M(3)67C, as indicated by reduced viability of su(f)12 versus su(f)+ sibs that are M(3)67C/+ (Girton, Langner, and Cejka, 1986, Roux's Arch. Dev. Biol. 195: 334-37).
su(f)13
A cell-autonomous, temperature-sensitive recessive allele. Phenotype similar to that of su(f)12 except that trypan-blue staining provides no evidence of cell death resulting from heat shock at stages of development in which such treatment induces leg duplications. Authors postulate that su(f)12 discs developmentally impaired by heat shock, giving rise to observed abnormalities. Temperature-sensitive period from late second instar until two hours into pupariation. Shifts from 22 to 29 during the first larval instar leads to inability to pupariate; shifts between 112 and 164 h arrests adult development; shifts within the first six hours after the temperature for lethality removes bristles from the tergites. Gynandromorphs and somatic clones formed normally at permissive temperatures, but are not observed in adults produced at 29. Ecdysteroid level of larvae raised at 29 are less than one-tenth that of wild type; pupariation can be induced by ecdysterone supplementation (Klose, Gateff, Emmerich, and Beikirch, 1980, Wilhelm Roux's Arch. Dev. Biol. 189: 57-67).
su(f)14
Temperature-sensitive lethal allele. Temperature-sensitive period for lethality extends from the second larval instar until twelve hours after pupariation. Shifting adult females to restrictive conditions results in the gradual abolition of oviposition; during the first day normal appearing eggs, many of which hatch, are produced, on the second day the hatchability of the eggs is reduced, and by day four the eggs are small and misshapen and lack chorions; oviposition ceases on the fifth or sixth day after shift up; at this time the ovary is deficient in stage 8-11 oocytes and lacks follicle cells indicating a breakdown in vitellogenesis. Shift back down to 25 leads to resumption of egg laying after four days. Ovarian response is autonomous in ovarian transplants. Fertility of males irreversibly impaired by shift up to 29.
su(f)23
Homozygotes and hemizygotes survive at all temperatures from 18 to 29; complements the lethality of lethal alleles. The suppression of f is temperature sensitive, but the sensitivity is of opposite sign from that of other temperature-sensitive alleles; f su(f)23 flies raised at 18 have suppressed forked bristles, whereas those raised at 29 are forked; the temperature-sensitive period sharply confined to the short interval at which bristle development is initiated. Does not appear to enhance M(3)67C.
su(f)24
Similar to su(f)1; enhancement of wa, however, seen only in su(f)1/su(f)24. Closely linked to or inseparable from a variable recessive abnormality giving small misshapen eyes.
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\su(f) for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.41

Gene model reviewed during 5.40

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.49

Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0113733
2574
733
FBtr0306544
2909
765
FBtr0306545
2668
733
Additional Transcript Data and Comments
Reported size (kB)

2.9, 2.6, 1.3 (northern blot)

Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0112456
84.5
733
8.45
FBpp0297502
88.2
765
8.39
FBpp0297503
84.5
733
8.45
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

733 aa isoforms: su(f)-PE, su(f)-PG
Additional Polypeptide Data and Comments
Reported size (kDa)

733, 351 (aa); 84, 39 (kD predicted)

Comments
External Data
Subunit Structure (UniProtKB)

Probably interacts with an RNA-binding protein.

(UniProt, P25991)
Crossreferences
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\su(f) using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
organism | ubiquitous

Comment: maternally deposited

northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data

su(f) protein accumulates in mitotically active cells in the embryo and larva.

Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\su(f) in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
EMBL-EBI Single Cell Expression Atlas
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 41 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 13 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of su(f)
Transgenic constructs containing regulatory region of su(f)
Aberrations (Deficiencies and Duplications) ( 339 )
Inferred from experimentation ( 339 )
Gene disrupted in
Gene not duplicated in
Gene not disrupted in
Gene duplicated in
Inferred from location ( 0 )
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
imaginal disc & metaphase & condensed nuclear chromosome | conditional ts
imaginal disc & mitotic metaphase | conditional ts
imaginal disc & spindle | conditional ts
larval brain & mitotic cell cycle
mitotic cell cycle & larval brain | conditional ts
nuclear chromosome & larval brain | conditional ts
Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
13 of 15
Yes
Yes
1  
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
13 of 15
Yes
Yes
Rattus norvegicus (Norway rat) (1)
8 of 13
Yes
Yes
Xenopus tropicalis (Western clawed frog) (9)
8 of 12
Yes
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
Danio rerio (Zebrafish) (1)
11 of 15
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (2)
11 of 15
Yes
Yes
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (1)
8 of 9
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (1)
11 of 15
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (1)
11 of 12
Yes
Yes
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091902YP )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091501OZ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W01KF )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X026K )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G02LY )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Ciona intestinalis
Vase tunicate
Gallus gallus
Domestic chicken
Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (0)
No records found.
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser

    Please see the Physical Interaction reports below for full details
    RNA-protein
    Physical Interaction
    Assay
    References
    protein-protein
    Physical Interaction
    Assay
    References
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement

    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    suppressible
    External Data
    Subunit Structure (UniProtKB)
    Probably interacts with an RNA-binding protein.
    (UniProt, P25991 )
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    External Data
    Linkouts
    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    X
    Recombination map
    1-66
    Cytogenetic map
    Sequence location
    X:23,096,771..23,101,431 [+]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    20E-20E
    Left limit from inclusion within Df(1)n23 (FBrf0055741) Right limit from inclusion within Df(1)EA113 (FBrf0046783)
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    20A-20B
    (determined by in situ hybridisation)
    20E-20F
    (determined by in situ hybridisation)
    20F-20F
    (determined by in situ hybridisation)
    20E-20E
    (determined by in situ hybridisation)
    su(f) is very close to the border between the polytenized and nonpolytenized regions of the X chromosome.
    Experimentally Determined Recombination Data
    Location
    Left of (cM)
    Notes

    Maps immediately proximal to sph.

    Maps adjacent to bb.

    Stocks and Reagents
    Stocks (26)
    Genomic Clones (13)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (158)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
      Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        Antibody Information
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        Source for merge of: su(f) l(1)G0393

        Additional comments
        Other Comments

        su(f) is required during cell division for progression through metaphase.

        The su(f) protein is involved in mRNA 3' formation, probably as part of the cleavage stimulation factor (CstF) complex. The su(f) protein specifically accumulates in mitotically-active cells.

        The level of Adh and Adhr transcripts in su(f) mutant and wild type background demonstrates the accumulation of the dicistronic messenger is controlled by a temperature-sensitive post-transcriptional mechanism.

        su(f) is closely flanked by 1.5kb repeated sequence (anon-k) in the same orientation. The sequences do not appear to be mobile. Database searches reveal that homologous sequences are often in the intervals between genes.

        Elimination of introns at su(f) by P-element mediated gene conversion shows that an RNA lacking a stop codon is dispensable.

        su(f) may regulate polyadenylation of one or several genes required for progression of the cell cycle.

        Does not have any effect on expression of the copia insertion mutant AdhRI-42.

        su(f) regulates its own expression as well as that of other genes at the level of polyA site selection.

        su(f) is not involved in the regulation of gypsy expression by flam.

        The wild type su(f) gene product either stimulates premature termination at the gypsy LTR or inhibits normal splicing.

        Recessive mutations at su(f) increase the fraction of wild type f transcripts.

        su(f) gene encodes a vital cell-autonomous function that is related to the phenotypic suppression of some mutants caused by insertion of transposable elements.

        Analysis of su(f) mutant alleles suggests that the su(f) locus contains multiple genetic functions. There are two distinct modifier functions and two vital functions. One modifier function is specific for enhancement and the other for suppression. One vital function is required for normal ecdysterone production in the third larval instar, the other is not.

        The most severely affected alleles are lethal, the lethal period becoming earlier with increasing severity. At least one instance of interallelic complementation has been reported by an allele which in surviving adults exhibits pale yellow thread-like chaetae. Viable alleles act as allele-specific but locus-nonspecific modifiers. The locus was recognized by the nearly wild-type bristle phenotype of f1 su(f)1; some bristles slightly shortened or twisted at tips. Autonomous in gynandromorphs.

        Mutations at su(f) and su(wa) modify the wa phenotype. Effects were determined in pairwise combinations and found to be additive or epistatic.

        The su(f) gene encodes a protein capable of gypsy repression.

        Mutant allele of su(f) exert no effect on wild type expression of Adh. Results suggest that loss of function results in partial suppression of the qualitative aspect of the AdhRI-42 phenotype.

        Suppressible alleles are spontaneous and contain insertions of transposable sequences; such alleles are also frequently modified by mutations in other modifier genes. For example, among alleles with gypsy inserts, su(f)1 suppresses ctK, lz1, f1, f5, Ubxbx-34e, but not y2, acHw-1, sc1, or ct6; all are suppressed by su(Hw)2. In addition, su(f)1 enhances the spontaneous mutants wa (copia) and lz37, but not we, lz34, lzK, s1, or v1 (412); all of these are affected by one or more other suppressor genotypes.

        Does not suppress the effect of f1 on the phenotype of dvr1, i.e. crumpled wings.

        su(f) mutations are found with several levels of reduced expression and some if not all mutant alleles are sensitive to temperature. The weakest exhibit no phenotype when raised at 25oC other than modification of the expression of specific alleles at other loci; increasingly reduced expression leads to a the visible phenotype.

        Mutant phenotype includes reduced or absent ocelli, missing ocellar bristles, irregular acrostichal rows, excessive melanization, especially on head and some crippling of legs.

        Minute-like bristles, rough eyes with some anterior indentation, missing head and thoracic bristles; also wings may be blistery, broader, with extra veins and may be held upward and outward.

        f alleles fall into two classes: suppressible (f1 and f5) and insuppressible (f3 and f3N).

        Origin and Etymology
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        External Crossreferences and Linkouts ( 51 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
        Other crossreferences
        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        EMBL-EBI Single Cell Expression Atlas
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        Flygut - An atlas of the Drosophila adult midgut
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
        KEGG Genes - Molecular building blocks of life in the genomic space.
        MARRVEL_MODEL
        modMine - A data warehouse for the modENCODE project
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
        FlyMine - An integrated database for Drosophila genomics
        KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
        MIST (genetic) - An integrated Molecular Interaction Database
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Synonyms and Secondary IDs (31)
        Reported As
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        Secondary FlyBase IDs
        • FBgn0028293
        • FBan0017170
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        References (228)