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Gene Dmel\su(Hw)

General Information
Symbol	Dmel\su(Hw)	Species	D. melanogaster
Name	suppressor of Hairy wing	Annotation symbol	CG8573
Feature type	protein_coding_gene	FlyBase ID	FBgn0003567
Gene Model Status	Current	Stock availability	24 publicly available
Also Known As	suHw
Genomic Location
Chromosome (arm)	3R	Recombination map	3-54.8
Cytogenetic map	88B3-88B3	Sequence location	3R:10,130,177..10,134,309 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene suppressor of Hairy wing is referred to in FlyBase by the symbol Dmel\su(Hw) (CG8573, FBgn0003567). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding; sequence-specific DNA binding; DNA binding; chromatin insulator sequence binding. There is experimental evidence that it is involved in the biological process: negative regulation of chromatin silencing; negative regulation of transcription, DNA-dependent. 58 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; cuticle; egg chamber. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Zinc finger C2H2-type/integrase DNA-binding domain; Zinc finger, C2H2; Zinc finger, C2H2-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval hindgut, larval Malpighian tubules, larval salivary gland, larval trachea, adult female reproductive system, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1631004_s_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of su(Hw). Gene sequence location is 3R:10130177..10134309.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	su(Hw): suppressor of Hairy wing In homozygous condition (e.g., su(Hw)2/su(Hw)2 or su(Hw)2/su(Hw)7) suppresses certain spontaneous alleles that contain gypsy inserts at a number of different loci, e.g., y2, Hw1, sc1, scD2, dm1, ct6, ctK, lz1, f1, f5, fK, B, Bxd2, h1, bx3, bx34e, bxd, bxd51j, bxd55i, bxdK, and ci1; alleles without gypsy inserts are not suppressed (see Lewis, 1949). Apparent exceptions to the above generalizations are scD1, which is suppressed and reportedly X ray induced and rsP1 and rsP2, both of which show temperature-sensitive suppression but no evidence of gypsy insertion. With the exception of lz37, which is enhanced by su(Hw), alleles not known, or known not, to contain gypsy, but which are modified by other suppressors are unaffected by su(Hw). Two alleles, ctK and fK, exhibit suppression in heterozygotes for either su(Hw) or a deficiency for su(Hw). su(Hw) causes accumulation of f transcript in flies carrying f alleles that ordinarily display low levels to return to wild-type levels (Parkhurst and Corces, 1985, Cell 41: 429-37); judging from results with y2, this is caused by reduction of transcription from the associated gypsy element (Parkhurst and Corces, 1986, Mol. Cell. Biol. 6: 47-53). Females homozygous for su(Hw)1, su(Hw)2, su(Hw)3, and su(Hw)4 are sterile; females homozygous for su(Hw)8 and transheterozygotes of su(Hw)7 with other allelles are fertile; su(Hw)7/su(Hw)2 are fertile and, in fact, suppress the female sterility of dm and lz (Grell). In sterile combinations, vitellogenesis inhibited leading to smaller-than-normal cysts surrounded by multiple layers of follicle cells; nurse cell chromosomes remain condensed until stage 9, after which egg chambers degenerate; ovarian phenotype autonomous in transplants (Klug et al., 1968, 1970). Reduced viability attributed to some alleles apparently caused by extraneous genes, since those alleles are perfectly viable in combination with su(Hw) deficiencies.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02	Controlled Vocabulary Terms sequence-specific DNA binding
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 88B3-88B3   Limits computationally determined from genome sequence between P{lacW}trxj14A6&P{PZ}trx00347 and P{PZ}cv-c06951
Experimentally Determined Cytological Location
Cytogenetic map Notes References 88B-88C   (determined by in situ hybridisation)   (Parkhurst et al., 1988)
Experimentally Determined Recombination Data
Location	3-54.8 (Georgiev and Gerasimova, 1989)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\su(Hw) for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.41
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) su(Hw)-RA FBtr0082946  NM_079625   3238   941 su(Hw)-RB FBtr0082945  NM_169574   3506   941 su(Hw)-RC FBtr0310002  NM_001260169   3680   941
Additional Transcript Data & Comments
Reported size (kB)	3.3 (northern blot) (Parkhurst et al., 1988)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein su(Hw)-PA   FBpp0082405   105.8   941   6.70     NP_524349   AAF55044 su(Hw)-PB   FBpp0082404   105.8   941   6.70     NP_731897   AAF55043 su(Hw)-PC   FBpp0301708   105.8   941   6.70     NP_001247098   AFH06416
Additional Polypeptide Data & Comments
Reported size (kDa)	944 (aa); 109 (kD) (Parkhurst et al., 1988)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger C2H2-type/integrase DNA-binding domain (IPR013087) Zinc finger, C2H2-like (IPR015880) Zinc finger, C2H2 (IPR007087)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA140853   AA140965   AA141301   AA392909   AA441105   AA539447   AA540805   AA816822   AE014297 AAF55043   AE014297 AAF55044   AE014297 AFH06416   AI515507   AI531212   AW942383   BI165862   BI165975   BI169559   BI173604   BI232361   BT003273 AAO25030   CK661356   CO184976   CO189979   CO283810   CO300157   CO304450   CO307959   CO310141   CO313917   CO317234   CO320313   CO324530   EC067157   EC076687   EC089059   EC195261   EC195460   EC200859   EC214917   EC219795   EC223128   EC224468   EC236546   EL879059   EV600216   Y00228 CAA68371
UniProtKB/Swiss-Prot	P08970
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Parkhurst et al., 1988) in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   antennal anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage central brain anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage dorsal head epidermis anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage visual anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage head mesoderm   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) ventral ectoderm   (Fisher et al., 2012) embryonic stage 9 -- 10   antennal primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium central brain primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium visual primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium dorsal head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium lateral head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium ventral head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium anterior endoderm   (Fisher et al., 2012) foregut primordium   (Fisher et al., 2012) head mesoderm   (Fisher et al., 2012) inclusive hindgut primordium   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 11 -- 12   anterior midgut primordium   (Fisher et al., 2012) cardiogenic mesoderm   (Fisher et al., 2012) central brain primordium   (Fisher et al., 2012) dorsal pharyngeal muscle primordium   (Fisher et al., 2012) fat body primordium   (Fisher et al., 2012) Comment:reported as fat body specific anlage fat body/gonad primordium   (Fisher et al., 2012) foregut primordium   (Fisher et al., 2012) head mesoderm   (Fisher et al., 2012) hindgut proper primordium   (Fisher et al., 2012) longitudinal visceral muscle primordium   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) posterior midgut primordium   (Fisher et al., 2012) proventriculus primordium   (Fisher et al., 2012) salivary gland body primordium   (Fisher et al., 2012) Comment:reported as salivary gland primordium somatic muscle primordium   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) visceral muscle primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic brain   (Fisher et al., 2012) embryonic foregut   (Fisher et al., 2012) embryonic hindgut   (Fisher et al., 2012) embryonic neuroblast of embryonic central brain   (Fisher et al., 2012) embryonic/larval midgut   (Fisher et al., 2012) embryonic/larval nervous system   (Fisher et al., 2012) embryonic/larval salivary gland   (Fisher et al., 2012) lateral cord surface glial cell   (Fisher et al., 2012) neuroblast of ventral nerve cord primordium   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012) northern blot Stage Tissue/Position (including subcellular localization) Reference oogenesis & adult stage | female   ovary   (Parkhurst et al., 1988)
Additional Descriptive Data
	The su(Hw) transcript is nearly absent in su(Hw)8 ovaries. (Parkhurst et al., 1988) su(Hw) transcripts are expressed throughout development and in ovaries. (Parkhurst et al., 1988)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Harrison et al., 1993) adult stage | female     (Harrison et al., 1993) adult stage | male     (Harrison et al., 1993)
Additional Descriptive Data
	su(Hw) protein is a ubiquitous nuclear protein detected in all developmental stages and in both sexes. (Harrison et al., 1993)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
chromatin inferred from direct assay (Kurshakova et al., 2007) nucleus inferred from direct assay (Kurshakova et al., 2007) inferred from direct assay (assigned by UniProtKB) (Harrison et al., 1993) polytene chromosome inferred from direct assay (Spana et al., 1988)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval hindgut, larval Malpighian tubules, larval salivary gland, larval trachea, adult female reproductive system, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    214.7 Larval Midgut    64 Larval Hindgut    113.7 Larval Malpighian Tubules    119 Larval Fat Body    69.3 Larval Salivary Gland    303.5 Larval Trachea    140.7 Larval Carcass    118.2 Adult Head    60.3 Adult Eye    50.8 Adult Brain    75.1 Adult Thoracic-Abdominal Ganglion    55.1 Adult Crop    92.1 Adult Midgut    64.4 Adult Hindgut    64.6 Adult Malpighian Tubules    99.8 Adult Fat Body    86.9 Adult Salivary Gland    85.2 Adult Heart    61.775 Adult VirginFemale Spermatheca    101.3 Adult InseminatedFemale Spermatheca    147.4 Adult Ovary    398.4 Adult Testis    89.2 Adult Male Accessory Gland    89.4 Adult Carcass    59.7 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    214.7 Larval Midgut    64 Larval Hindgut    113.7 Larval Malpighian Tubules    119 Larval Fat Body    69.3 Larval Salivary Gland    303.5 Larval Trachea    140.7 Larval Carcass    118.2 Adult Head    60.3 Adult Eye    50.8 Adult Brain    75.1 Adult Thoracic-Abdominal Ganglion    55.1 Adult Crop    92.1 Adult Midgut    64.4 Adult Hindgut    64.6 Adult Malpighian Tubules    99.8 Adult Fat Body    86.9 Adult Salivary Gland    85.2 Adult Heart    61.775 Adult VirginFemale Spermatheca    101.3 Adult InseminatedFemale Spermatheca    147.4 Adult Ovary    398.4 Adult Testis    89.2 Adult Male Accessory Gland    89.4 Adult Carcass    59.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    214.7 Larval Midgut    64 Larval Hindgut    113.7 Larval Malpighian Tubules    119 Larval Fat Body    69.3 Larval Salivary Gland    303.5 Larval Trachea    140.7 Larval Carcass    118.2 Adult Head    60.3 Adult Eye    50.8 Adult Brain    75.1 Adult Thoracic-Abdominal Ganglion    55.1 Adult Crop    92.1 Adult Midgut    64.4 Adult Hindgut    64.6 Adult Malpighian Tubules    99.8 Adult Fat Body    86.9 Adult Salivary Gland    85.2 Adult Heart    61.775 Adult VirginFemale Spermatheca    101.3 Adult InseminatedFemale Spermatheca    147.4 Adult Ovary    398.4 Adult Testis    89.2 Adult Male Accessory Gland    89.4 Adult Carcass    59.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    214.7 Larval Midgut    64 Larval Hindgut    113.7 Larval Malpighian Tubules    119 Larval Fat Body    69.3 Larval Salivary Gland    303.5 Larval Trachea    140.7 Larval Carcass    118.2 Adult Head    60.3 Adult Eye    50.8 Adult Brain    75.1 Adult Thoracic-Abdominal Ganglion    55.1 Adult Crop    92.1 Adult Midgut    64.4 Adult Hindgut    64.6 Adult Malpighian Tubules    99.8 Adult Fat Body    86.9 Adult Salivary Gland    85.2 Adult Heart    61.775 Adult VirginFemale Spermatheca    101.3 Adult InseminatedFemale Spermatheca    147.4 Adult Ovary    398.4 Adult Testis    89.2 Adult Male Accessory Gland    89.4 Adult Carcass    59.7 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    214.7 Larval Midgut    64 Larval Hindgut    113.7 Larval Malpighian Tubules    119 Larval Fat Body    69.3 Larval Salivary Gland    303.5 Larval Trachea    140.7 Larval Carcass    118.2 Adult Head    60.3 Adult Eye    50.8 Adult Brain    75.1 Adult Thoracic-Abdominal Ganglion    55.1 Adult Crop    92.1 Adult Midgut    64.4 Adult Hindgut    64.6 Adult Malpighian Tubules    99.8 Adult Fat Body    86.9 Adult Salivary Gland    85.2 Adult Heart    61.775 Adult VirginFemale Spermatheca    101.3 Adult InseminatedFemale Spermatheca    147.4 Adult Ovary    398.4 Adult Testis    89.2 Adult Male Accessory Gland    89.4 Adult Carcass    59.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    214.7 Larval Midgut    64 Larval Hindgut    113.7 Larval Malpighian Tubules    119 Larval Fat Body    69.3 Larval Salivary Gland    303.5 Larval Trachea    140.7 Larval Carcass    118.2 Adult Head    60.3 Adult Eye    50.8 Adult Brain    75.1 Adult Thoracic-Abdominal Ganglion    55.1 Adult Crop    92.1 Adult Midgut    64.4 Adult Hindgut    64.6 Adult Malpighian Tubules    99.8 Adult Fat Body    86.9 Adult Salivary Gland    85.2 Adult Heart    61.775 Adult VirginFemale Spermatheca    101.3 Adult InseminatedFemale Spermatheca    147.4 Adult Ovary    398.4 Adult Testis    89.2 Adult Male Accessory Gland    89.4 Adult Carcass    59.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    214.7 Larval Midgut    64 Larval Hindgut    113.7 Larval Malpighian Tubules    119 Larval Fat Body    69.3 Larval Salivary Gland    303.5 Larval Trachea    140.7 Larval Carcass    118.2 Adult Head    60.3 Adult Eye    50.8 Adult Brain    75.1 Adult Thoracic-Abdominal Ganglion    55.1 Adult Crop    92.1 Adult Midgut    64.4 Adult Hindgut    64.6 Adult Malpighian Tubules    99.8 Adult Fat Body    86.9 Adult Salivary Gland    85.2 Adult Heart    61.775 Adult VirginFemale Spermatheca    101.3 Adult InseminatedFemale Spermatheca    147.4 Adult Ovary    398.4 Adult Testis    89.2 Adult Male Accessory Gland    89.4 Adult Carcass    59.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    214.7 Larval Midgut    64 Larval Hindgut    113.7 Larval Malpighian Tubules    119 Larval Fat Body    69.3 Larval Salivary Gland    303.5 Larval Trachea    140.7 Larval Carcass    118.2 Adult Head    60.3 Adult Eye    50.8 Adult Brain    75.1 Adult Thoracic-Abdominal Ganglion    55.1 Adult Crop    92.1 Adult Midgut    64.4 Adult Hindgut    64.6 Adult Malpighian Tubules    99.8 Adult Fat Body    86.9 Adult Salivary Gland    85.2 Adult Heart    61.775 Adult VirginFemale Spermatheca    101.3 Adult InseminatedFemale Spermatheca    147.4 Adult Ovary    398.4 Adult Testis    89.2 Adult Male Accessory Gland    89.4 Adult Carcass    59.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    60.3   NA  Eye    50.8   NA  Brain    75.1   214.7  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    55.1   NA  Crop    92.1   64  Midgut    64.4   113.7  Hindgut    64.6   119  Malpighian Tubules    99.8   69.3  Fat Body    86.9   303.5  Salivary Gland    85.2   NA  Heart    61.775   140.7  Trachea    NA   NA  VirginFemale Spermatheca    101.3   NA  InseminatedFemale Spermatheca    147.4   NA  Ovary    398.4   NA  Testis    89.2   NA  Male Accessory Gland    89.4   118.2  Carcass    59.7 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    31 central nervous system, larvae L3    20 central nervous system, pupae P8    9 head, virgin 1-day female    6 head, virgin 4-day female    6 head, virgin 20-day female    4 head, mated 1-day female    7 head, mated 4-day female    6 head, mated 20-day female    5 head, mated 1-day male    7 head, mated 4-day male    9 head, mated 20-day male    11 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    15 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    6 digestive system, 4-day adult    10 digestive system, 20-day adult    7 fat body, larvae L3 wandering    3 fat body, white prepupae    14 fat body, pupae P8    27 carcass, larvae L3 wandering    25 carcass, 1-day adult    7 carcass, 4-day adult    10 carcass, 20-day adult    6 ovary, virgin 4-day female    76 ovary, mated 4-day female    69 testis, mated 4-day male    17 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (31) central nervous system, larvae L3    20 central nervous system, pupae P8    9 head, virgin 1-day female    6 head, virgin 4-day female    6 head, virgin 20-day female    4 head, mated 1-day female    7 head, mated 4-day female    6 head, mated 20-day female    5 head, mated 1-day male    7 head, mated 4-day male    9 head, mated 20-day male    11 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    15 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    6 digestive system, 4-day adult    10 digestive system, 20-day adult    7 fat body, larvae L3 wandering    3 fat body, white prepupae    14 fat body, pupae P8  (27) carcass, larvae L3 wandering    25 carcass, 1-day adult    7 carcass, 4-day adult    10 carcass, 20-day adult    6 ovary, virgin 4-day female  (76) ovary, mated 4-day female  (69) testis, mated 4-day male    17 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    31 central nervous system, larvae L3    20 central nervous system, pupae P8    9 head, virgin 1-day female    6 head, virgin 4-day female    6 head, virgin 20-day female    4 head, mated 1-day female    7 head, mated 4-day female    6 head, mated 20-day female    5 head, mated 1-day male    7 head, mated 4-day male    9 head, mated 20-day male    11 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    15 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    6 digestive system, 4-day adult    10 digestive system, 20-day adult    7 fat body, larvae L3 wandering    3 fat body, white prepupae    14 fat body, pupae P8    27 carcass, larvae L3 wandering    25 carcass, 1-day adult    7 carcass, 4-day adult    10 carcass, 20-day adult    6 ovary, virgin 4-day female    76 ovary, mated 4-day female    69 testis, mated 4-day male    17 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    31 central nervous system, larvae L3    20 central nervous system, pupae P8    9 head, virgin 1-day female    6 head, virgin 4-day female    6 head, virgin 20-day female    4 head, mated 1-day female    7 head, mated 4-day female    6 head, mated 20-day female    5 head, mated 1-day male    7 head, mated 4-day male    9 head, mated 20-day male    11 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    15 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    6 digestive system, 4-day adult    10 digestive system, 20-day adult    7 fat body, larvae L3 wandering    3 fat body, white prepupae    14 fat body, pupae P8    27 carcass, larvae L3 wandering    25 carcass, 1-day adult    7 carcass, 4-day adult    10 carcass, 20-day adult    6 ovary, virgin 4-day female    76 ovary, mated 4-day female    69 testis, mated 4-day male    17 accessory gland, mated 4-day male    8 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    31 central nervous system, larvae L3    20 central nervous system, pupae P8    9 head, virgin 1-day female    6 head, virgin 4-day female    6 head, virgin 20-day female    4 head, mated 1-day female    7 head, mated 4-day female    6 head, mated 20-day female    5 head, mated 1-day male    7 head, mated 4-day male    9 head, mated 20-day male    11 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    15 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    6 digestive system, 4-day adult    10 digestive system, 20-day adult    7 fat body, larvae L3 wandering    3 fat body, white prepupae    14 fat body, pupae P8    27 carcass, larvae L3 wandering    25 carcass, 1-day adult    7 carcass, 4-day adult    10 carcass, 20-day adult    6 ovary, virgin 4-day female    76 ovary, mated 4-day female    69 testis, mated 4-day male    17 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  31 central nervous system, larvae L3    20 central nervous system, pupae P8    9 head, virgin 1-day female    6 head, virgin 4-day female    6 head, virgin 20-day female    4 head, mated 1-day female    7 head, mated 4-day female    6 head, mated 20-day female    5 head, mated 1-day male    7 head, mated 4-day male    9 head, mated 20-day male    11 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    15 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    6 digestive system, 4-day adult    10 digestive system, 20-day adult    7 fat body, larvae L3 wandering    3 fat body, white prepupae    14 fat body, pupae P8  27 carcass, larvae L3 wandering    25 carcass, 1-day adult    7 carcass, 4-day adult    10 carcass, 20-day adult    6 ovary, virgin 4-day female  (76) ovary, mated 4-day female  (69) testis, mated 4-day male    17 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    31 central nervous system, larvae L3    20 central nervous system, pupae P8    9 head, virgin 1-day female    6 head, virgin 4-day female    6 head, virgin 20-day female    4 head, mated 1-day female    7 head, mated 4-day female    6 head, mated 20-day female    5 head, mated 1-day male    7 head, mated 4-day male    9 head, mated 20-day male    11 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    15 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    6 digestive system, 4-day adult    10 digestive system, 20-day adult    7 fat body, larvae L3 wandering    3 fat body, white prepupae    14 fat body, pupae P8    27 carcass, larvae L3 wandering    25 carcass, 1-day adult    7 carcass, 4-day adult    10 carcass, 20-day adult    6 ovary, virgin 4-day female    76 ovary, mated 4-day female    69 testis, mated 4-day male    17 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    31 central nervous system, larvae L3    20 central nervous system, pupae P8    9 head, virgin 1-day female    6 head, virgin 4-day female    6 head, virgin 20-day female    4 head, mated 1-day female    7 head, mated 4-day female    6 head, mated 20-day female    5 head, mated 1-day male    7 head, mated 4-day male    9 head, mated 20-day male    11 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    15 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    6 digestive system, 4-day adult    10 digestive system, 20-day adult    7 fat body, larvae L3 wandering    3 fat body, white prepupae    14 fat body, pupae P8    27 carcass, larvae L3 wandering    25 carcass, 1-day adult    7 carcass, 4-day adult    10 carcass, 20-day adult    6 ovary, virgin 4-day female    76 ovary, mated 4-day female    69 testis, mated 4-day male    17 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    52 embryo 02-04hr    84 embryo 04-06hr    64 embryo 06-08hr    77 embryo 08-10hr    73 embryo 10-12hr    66 embryo 12-14hr    44 embryo 14-16hr    30 embryo 16-18hr    23 embryo 18-20hr    14 embryo 20-22hr    32 embryo 22-24hr    27 larva L1    9 larva L2    13 larva L3 12hr old    8 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    18 white prepupae new    19 white prepupae 12hr    20 white prepupae 24hr    25 pupae 2d postWPP    20 pupae 3d postWPP    9 pupae 4d postWPP    7 adult male 01day    8 adult male 05day    10 adult male 30day    8 adult female 01day    16 adult female 05day    29 adult female 30day    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (52) embryo 02-04hr  (84) embryo 04-06hr  (64) embryo 06-08hr  (77) embryo 08-10hr  (73) embryo 10-12hr  (66) embryo 12-14hr  (44) embryo 14-16hr  (30) embryo 16-18hr    23 embryo 18-20hr    14 embryo 20-22hr  (32) embryo 22-24hr  (27) larva L1    9 larva L2    13 larva L3 12hr old    8 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    18 white prepupae new    19 white prepupae 12hr    20 white prepupae 24hr    25 pupae 2d postWPP    20 pupae 3d postWPP    9 pupae 4d postWPP    7 adult male 01day    8 adult male 05day    10 adult male 30day    8 adult female 01day    16 adult female 05day  (29) adult female 30day  (29) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    52 embryo 02-04hr    84 embryo 04-06hr    64 embryo 06-08hr    77 embryo 08-10hr    73 embryo 10-12hr    66 embryo 12-14hr    44 embryo 14-16hr    30 embryo 16-18hr    23 embryo 18-20hr    14 embryo 20-22hr    32 embryo 22-24hr    27 larva L1    9 larva L2    13 larva L3 12hr old    8 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    18 white prepupae new    19 white prepupae 12hr    20 white prepupae 24hr    25 pupae 2d postWPP    20 pupae 3d postWPP    9 pupae 4d postWPP    7 adult male 01day    8 adult male 05day    10 adult male 30day    8 adult female 01day    16 adult female 05day    29 adult female 30day    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    52 embryo 02-04hr    84 embryo 04-06hr    64 embryo 06-08hr    77 embryo 08-10hr    73 embryo 10-12hr    66 embryo 12-14hr    44 embryo 14-16hr    30 embryo 16-18hr    23 embryo 18-20hr    14 embryo 20-22hr    32 embryo 22-24hr    27 larva L1    9 larva L2    13 larva L3 12hr old    8 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    18 white prepupae new    19 white prepupae 12hr    20 white prepupae 24hr    25 pupae 2d postWPP    20 pupae 3d postWPP    9 pupae 4d postWPP    7 adult male 01day    8 adult male 05day    10 adult male 30day    8 adult female 01day    16 adult female 05day    29 adult female 30day    29 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    52 embryo 02-04hr    84 embryo 04-06hr    64 embryo 06-08hr    77 embryo 08-10hr    73 embryo 10-12hr    66 embryo 12-14hr    44 embryo 14-16hr    30 embryo 16-18hr    23 embryo 18-20hr    14 embryo 20-22hr    32 embryo 22-24hr    27 larva L1    9 larva L2    13 larva L3 12hr old    8 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    18 white prepupae new    19 white prepupae 12hr    20 white prepupae 24hr    25 pupae 2d postWPP    20 pupae 3d postWPP    9 pupae 4d postWPP    7 adult male 01day    8 adult male 05day    10 adult male 30day    8 adult female 01day    16 adult female 05day    29 adult female 30day    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (52) embryo 02-04hr  (84) embryo 04-06hr  (64) embryo 06-08hr  (77) embryo 08-10hr  (73) embryo 10-12hr  (66) embryo 12-14hr  (44) embryo 14-16hr  30 embryo 16-18hr    23 embryo 18-20hr    14 embryo 20-22hr  32 embryo 22-24hr  27 larva L1    9 larva L2    13 larva L3 12hr old    8 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    18 white prepupae new    19 white prepupae 12hr    20 white prepupae 24hr    25 pupae 2d postWPP    20 pupae 3d postWPP    9 pupae 4d postWPP    7 adult male 01day    8 adult male 05day    10 adult male 30day    8 adult female 01day    16 adult female 05day  29 adult female 30day  29 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    52 embryo 02-04hr    84 embryo 04-06hr    64 embryo 06-08hr    77 embryo 08-10hr    73 embryo 10-12hr    66 embryo 12-14hr    44 embryo 14-16hr    30 embryo 16-18hr    23 embryo 18-20hr    14 embryo 20-22hr    32 embryo 22-24hr    27 larva L1    9 larva L2    13 larva L3 12hr old    8 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    18 white prepupae new    19 white prepupae 12hr    20 white prepupae 24hr    25 pupae 2d postWPP    20 pupae 3d postWPP    9 pupae 4d postWPP    7 adult male 01day    8 adult male 05day    10 adult male 30day    8 adult female 01day    16 adult female 05day    29 adult female 30day    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    52 embryo 02-04hr    84 embryo 04-06hr    64 embryo 06-08hr    77 embryo 08-10hr    73 embryo 10-12hr    66 embryo 12-14hr    44 embryo 14-16hr    30 embryo 16-18hr    23 embryo 18-20hr    14 embryo 20-22hr    32 embryo 22-24hr    27 larva L1    9 larva L2    13 larva L3 12hr old    8 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    18 white prepupae new    19 white prepupae 12hr    20 white prepupae 24hr    25 pupae 2d postWPP    20 pupae 3d postWPP    9 pupae 4d postWPP    7 adult male 01day    8 adult male 05day    10 adult male 30day    8 adult female 01day    16 adult female 05day    29 adult female 30day    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    43 Schneider line 2 Sg4    39 embryonic 1182-4H    31 embryonic GM2    29 embryonic Kc167    30 embryonic S1    39 embryonic S3    48 leg disc CME L1    28 wing disc CME-W2    19 wing disc ML-DmD8    21 wing disc ML-DmD9    21 wing disc ML-DmD16-c3    30 wing disc ML-DmD21    44 wing disc ML-DmD32    22 haltere disc ML-DmD17-c3    33 eye-antennal disc ML-DmD11    19 antennal disc ML-DmD20-c5    16 mixed discs ML-DmD4-c1    42 CNS ML-DmBG1-c1    37 CNS ML-DmBG2-c2    37 tumorous blood cells mbn2    21 ovary fGS/OSS    30 ovary OSC    34 ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (43) Schneider line 2 Sg4  (39) embryonic 1182-4H  (31) embryonic GM2  (29) embryonic Kc167  (30) embryonic S1  (39) embryonic S3  (48) leg disc CME L1  (28) wing disc CME-W2    19 wing disc ML-DmD8    21 wing disc ML-DmD9    21 wing disc ML-DmD16-c3  (30) wing disc ML-DmD21  (44) wing disc ML-DmD32    22 haltere disc ML-DmD17-c3  (33) eye-antennal disc ML-DmD11    19 antennal disc ML-DmD20-c5    16 mixed discs ML-DmD4-c1  (42) CNS ML-DmBG1-c1  (37) CNS ML-DmBG2-c2  (37) tumorous blood cells mbn2    21 ovary fGS/OSS  (30) ovary OSC  (34) ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    43 Schneider line 2 Sg4    39 embryonic 1182-4H    31 embryonic GM2    29 embryonic Kc167    30 embryonic S1    39 embryonic S3    48 leg disc CME L1    28 wing disc CME-W2    19 wing disc ML-DmD8    21 wing disc ML-DmD9    21 wing disc ML-DmD16-c3    30 wing disc ML-DmD21    44 wing disc ML-DmD32    22 haltere disc ML-DmD17-c3    33 eye-antennal disc ML-DmD11    19 antennal disc ML-DmD20-c5    16 mixed discs ML-DmD4-c1    42 CNS ML-DmBG1-c1    37 CNS ML-DmBG2-c2    37 tumorous blood cells mbn2    21 ovary fGS/OSS    30 ovary OSC    34 ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    43 Schneider line 2 Sg4    39 embryonic 1182-4H    31 embryonic GM2    29 embryonic Kc167    30 embryonic S1    39 embryonic S3    48 leg disc CME L1    28 wing disc CME-W2    19 wing disc ML-DmD8    21 wing disc ML-DmD9    21 wing disc ML-DmD16-c3    30 wing disc ML-DmD21    44 wing disc ML-DmD32    22 haltere disc ML-DmD17-c3    33 eye-antennal disc ML-DmD11    19 antennal disc ML-DmD20-c5    16 mixed discs ML-DmD4-c1    42 CNS ML-DmBG1-c1    37 CNS ML-DmBG2-c2    37 tumorous blood cells mbn2    21 ovary fGS/OSS    30 ovary OSC    34 ovary OSS    19 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    43 Schneider line 2 Sg4    39 embryonic 1182-4H    31 embryonic GM2    29 embryonic Kc167    30 embryonic S1    39 embryonic S3    48 leg disc CME L1    28 wing disc CME-W2    19 wing disc ML-DmD8    21 wing disc ML-DmD9    21 wing disc ML-DmD16-c3    30 wing disc ML-DmD21    44 wing disc ML-DmD32    22 haltere disc ML-DmD17-c3    33 eye-antennal disc ML-DmD11    19 antennal disc ML-DmD20-c5    16 mixed discs ML-DmD4-c1    42 CNS ML-DmBG1-c1    37 CNS ML-DmBG2-c2    37 tumorous blood cells mbn2    21 ovary fGS/OSS    30 ovary OSC    34 ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (43) Schneider line 2 Sg4  (39) embryonic 1182-4H  31 embryonic GM2  29 embryonic Kc167  30 embryonic S1  (39) embryonic S3  (48) leg disc CME L1  28 wing disc CME-W2    19 wing disc ML-DmD8    21 wing disc ML-DmD9    21 wing disc ML-DmD16-c3  30 wing disc ML-DmD21  (44) wing disc ML-DmD32    22 haltere disc ML-DmD17-c3  (33) eye-antennal disc ML-DmD11    19 antennal disc ML-DmD20-c5    16 mixed discs ML-DmD4-c1  (42) CNS ML-DmBG1-c1  (37) CNS ML-DmBG2-c2  (37) tumorous blood cells mbn2    21 ovary fGS/OSS  30 ovary OSC  (34) ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    43 Schneider line 2 Sg4    39 embryonic 1182-4H    31 embryonic GM2    29 embryonic Kc167    30 embryonic S1    39 embryonic S3    48 leg disc CME L1    28 wing disc CME-W2    19 wing disc ML-DmD8    21 wing disc ML-DmD9    21 wing disc ML-DmD16-c3    30 wing disc ML-DmD21    44 wing disc ML-DmD32    22 haltere disc ML-DmD17-c3    33 eye-antennal disc ML-DmD11    19 antennal disc ML-DmD20-c5    16 mixed discs ML-DmD4-c1    42 CNS ML-DmBG1-c1    37 CNS ML-DmBG2-c2    37 tumorous blood cells mbn2    21 ovary fGS/OSS    30 ovary OSC    34 ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    43 Schneider line 2 Sg4    39 embryonic 1182-4H    31 embryonic GM2    29 embryonic Kc167    30 embryonic S1    39 embryonic S3    48 leg disc CME L1    28 wing disc CME-W2    19 wing disc ML-DmD8    21 wing disc ML-DmD9    21 wing disc ML-DmD16-c3    30 wing disc ML-DmD21    44 wing disc ML-DmD32    22 haltere disc ML-DmD17-c3    33 eye-antennal disc ML-DmD11    19 antennal disc ML-DmD20-c5    16 mixed discs ML-DmD4-c1    42 CNS ML-DmBG1-c1    37 CNS ML-DmBG2-c2    37 tumorous blood cells mbn2    21 ovary fGS/OSS    30 ovary OSC    34 ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    9 heat shock, 4-day adult    20 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    22 Cadmium 100 mM 48 hrs, 4-day adult    43 Copper 0.5 mM 12 hrs, larvae L3    11 Copper 15 mM 48 hrs, 4-day adult    37 Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3    35 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    36 Caffeine 25 mg/ml 48 hrs, 4-day adult    17 Paraquat 5 mM 48 hrs, 4-day adult    35 Paraquat 10 mM 48 hrs, 4-day adult    25 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    9 heat shock, 4-day adult    20 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    22 Cadmium 100 mM 48 hrs, 4-day adult  (43) Copper 0.5 mM 12 hrs, larvae L3    11 Copper 15 mM 48 hrs, 4-day adult  (37) Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3  (35) Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (36) Caffeine 25 mg/ml 48 hrs, 4-day adult    17 Paraquat 5 mM 48 hrs, 4-day adult  (35) Paraquat 10 mM 48 hrs, 4-day adult    25 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    9 heat shock, 4-day adult    20 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    22 Cadmium 100 mM 48 hrs, 4-day adult    43 Copper 0.5 mM 12 hrs, larvae L3    11 Copper 15 mM 48 hrs, 4-day adult    37 Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3    35 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    36 Caffeine 25 mg/ml 48 hrs, 4-day adult    17 Paraquat 5 mM 48 hrs, 4-day adult    35 Paraquat 10 mM 48 hrs, 4-day adult    25 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    9 heat shock, 4-day adult    20 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    22 Cadmium 100 mM 48 hrs, 4-day adult    43 Copper 0.5 mM 12 hrs, larvae L3    11 Copper 15 mM 48 hrs, 4-day adult    37 Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3    35 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    36 Caffeine 25 mg/ml 48 hrs, 4-day adult    17 Paraquat 5 mM 48 hrs, 4-day adult    35 Paraquat 10 mM 48 hrs, 4-day adult    25 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    9 heat shock, 4-day adult    20 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    22 Cadmium 100 mM 48 hrs, 4-day adult    43 Copper 0.5 mM 12 hrs, larvae L3    11 Copper 15 mM 48 hrs, 4-day adult    37 Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3    35 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    36 Caffeine 25 mg/ml 48 hrs, 4-day adult    17 Paraquat 5 mM 48 hrs, 4-day adult    35 Paraquat 10 mM 48 hrs, 4-day adult    25 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    9 heat shock, 4-day adult    20 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    22 Cadmium 100 mM 48 hrs, 4-day adult  (43) Copper 0.5 mM 12 hrs, larvae L3    11 Copper 15 mM 48 hrs, 4-day adult  (37) Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3  (35) Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (36) Caffeine 25 mg/ml 48 hrs, 4-day adult    17 Paraquat 5 mM 48 hrs, 4-day adult  (35) Paraquat 10 mM 48 hrs, 4-day adult    25 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    9 heat shock, 4-day adult    20 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    22 Cadmium 100 mM 48 hrs, 4-day adult    43 Copper 0.5 mM 12 hrs, larvae L3    11 Copper 15 mM 48 hrs, 4-day adult    37 Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3    35 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    36 Caffeine 25 mg/ml 48 hrs, 4-day adult    17 Paraquat 5 mM 48 hrs, 4-day adult    35 Paraquat 10 mM 48 hrs, 4-day adult    25 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    9 heat shock, 4-day adult    20 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    22 Cadmium 100 mM 48 hrs, 4-day adult    43 Copper 0.5 mM 12 hrs, larvae L3    11 Copper 15 mM 48 hrs, 4-day adult    37 Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3    35 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    36 Caffeine 25 mg/ml 48 hrs, 4-day adult    17 Paraquat 5 mM 48 hrs, 4-day adult    35 Paraquat 10 mM 48 hrs, 4-day adult    25 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_17 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	BDGP expression data • LD15893 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003567 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8573-RB
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | heat sensitive su(Hw)GAL4BD.hs lethal | recessive su(Hw)e7 partially lethal - majority die | pupal stage, with Scer\GAL4pnr-MD237 su(Hw)GD4493 viable su(Hw)V Sterility Allele female sterile su(Hw)2 su(Hw)3 su(Hw)5 su(Hw)6 su(Hw)E8 su(Hw)V su(Hw)Δ100 female sterile | recessive su(Hw)V male sterile su(Hw)5 su(Hw)6 Other Phenotypes Allele visible, with Scer\GAL4pnr-MD237 su(Hw)GD4493 wild-type su(Hw)+t5.2 su(Hw)+t9.5 su(Hw)+t18 su(Hw)wt su(Hw)Δ2-203 su(Hw)Δ656-705 su(Hw)Δ706-736 su(Hw)Δ881-944 Phenotype manifest in Allele cuticle su(Hw)ΔB su(Hw)ΔC egg chamber su(Hw)V trichogen cell, with Scer\GAL4pnr-MD237 su(Hw)GD4493
Classical Alleles ( 23 )
For All Classical Alleles Show
Allele of su(Hw) Class Mutagen Stocks Known lesion su(Hw)2 hypomorphic allele - genetic evidence spontaneous 12 Yes su(Hw)3 ethyl methanesulfonate 2 Yes su(Hw)5 gamma ray 2 Yes su(Hw)8 spontaneous 2 Yes su(Hw)e04061 piggyBac transposase 2 -- su(Hw)V loss of function allele, amorphic allele - genetic evidence gamma ray ethyl methanesulfonate 0 Yes su(Hw)10l25 spontaneous 0 -- su(Hw)1 spontaneous 0 -- su(Hw)29 spontaneous 0 -- su(Hw)4 ethyl methanesulfonate 0 -- su(Hw)6 gamma ray 0 Yes su(Hw)7 hypomorphic allele - genetic evidence ethyl methanesulfonate spontaneous 0 Yes su(Hw)7a24 spontaneous 0 -- su(Hw)e1 loss of function allele 0 -- su(Hw)e2 ethyl methanesulfonate 0 Yes su(Hw)e3 loss of function allele 0 -- su(Hw)e7 ethyl methanesulfonate 0 Yes su(Hw)E8 ethyl methanesulfonate 0 Yes su(Hw)J ethyl methanesulfonate 0 Yes su(Hw)MC 0 -- su(Hw)u1 transposable element activity 0 -- su(Hw)u2 transposable element activity 0 -- su(Hw)unspecified 0 --
Alleles Carried on Transgenic Constructs ( 35 )
For All Alleles Carried on Transgenic Constructs Show
Allele of su(Hw) Class Mutagen Stocks Known lesion su(Hw)GAL4BD.hs in vitro construct - regulatory fusion in vitro construct - coding region fusion 1 Yes su(Hw)GD4493 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes su(Hw)HMS00848 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes su(Hw)HMS00970 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes su(Hw)JF01189 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes su(Hw)KK104142 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes su(Hw)+t18 in vitro construct - genomic fragment 0 Yes su(Hw)+t5.2 in vitro construct - genomic fragment 0 Yes su(Hw)+t9.5 in vitro construct - genomic fragment 0 Yes su(Hw)5.3.T:Avic\GFP in vitro construct - coding region fusion 0 Yes su(Hw)D765N in vitro construct - amino acid replacement 0 Yes su(Hw)L775K in vitro construct - amino acid replacement 0 Yes su(Hw)NIG.8573R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes su(Hw)NoAD2 in vitro construct 0 Yes su(Hw)NoAD in vitro construct - deletion 0 Yes su(Hw)Scer\UAS.cBa in vitro construct - regulatory fusion 0 Yes su(Hw)T:Scer\GAL4 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes su(Hw)tHa in vitro construct - genomic fragment 0 Yes su(Hw)tR144Xb14 in vitro construct - genomic fragment 0 Yes su(Hw)wt in vitro construct 0 Yes su(Hw)Δ100 in vitro construct - deletion 0 Yes su(Hw)Δ2-203.673-943 in vitro construct - deletion 0 Yes su(Hw)Δ2-203 in vitro construct - deletion 0 Yes su(Hw)Δ283 in vitro construct - deletion 0 Yes su(Hw)Δ656-705 in vitro construct - deletion 0 Yes su(Hw)Δ673-943 in vitro construct - deletion 0 Yes su(Hw)Δ706-736 in vitro construct - deletion 0 Yes su(Hw)Δ738-780 in vitro construct - deletion 0 Yes su(Hw)Δ782-944 in vitro construct - deletion 0 Yes su(Hw)Δ853-880 in vitro construct - deletion 0 Yes su(Hw)Δ881-944 in vitro construct - deletion 0 Yes su(Hw)ΔA in vitro construct - deletion 0 Yes su(Hw)ΔB in vitro construct - deletion 0 Yes su(Hw)ΔC in vitro construct - deletion 0 Yes su(Hw)ΔCTAD in vitro construct - deletion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)BSC487 (Christensen et al., 2008.4.15) Df(3R)Exel6267 (Ryder, 2004.4.26) Df(3R)red2l (Breen and Harte, 1991) Df(3R)red3l (Jarman and Collett, 1998) Df(3R)red-P1 (Jarman and Collett, 1998, Mortin et al., 1992) Df(3R)red-P6 (Breen and Harte, 1991, Mortin et al., 1992) Df(3R)red-P52 (Jarman and Collett, 1998, Breen and Harte, 1991, Mortin et al., 1992, Lewis, 1981, Landis et al., 1997) Df(3R)red-P93 (Breen and Harte, 1991, Mortin et al., 1992, Landis et al., 1997) Df(3R)su(Hw)7 (Jarman and Collett, 1998) Df(3R)su(Hw)V (Breen and Harte, 1991, Mortin et al., 1992, Harrison et al., 1992, Roseman et al., 1995) Df(3R)trxE12 (Breen and Harte, 1991)
Duplicated in	Dp(3;1)O5
Not disrupted in	Df(3R)293γ5 (Jarman and Collett, 1998, Mortin et al., 1992, Landis et al., 1997) Df(3R)293γ7 (Jarman and Collett, 1998, Landis et al., 1997) Df(3R)JY19 (Breen and Harte, 1991) Df(3R)JY28 (Breen and Harte, 1991) Df(3R)l26c (Jarman and Collett, 1998) Df(3R)M36 (Jarman and Collett, 1998) Df(3R)M49 (Jarman and Collett, 1998) Df(3R)urd (Jarman and Collett, 1998) T(Y;3)redP4 (Breen and Harte, 1991)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4493} NA P{KK104142} NA P{NIG.8573R} NA P{TRiP.HMS00848} NA P{TRiP.HMS00970} NA P{TRiP.JF01189} NA P{UAS-su(Hw).B} NA GAL4 construct P{GAL4::su(Hw)-hb} No characterization construct P{CaSX/K5.3} NA P{mod(mdg4)::su(Hw).G} NA P{R144Xb14} NA P{su(Hw)5.2} NA P{su(Hw)9.5} NA P{su(Hw)18} NA P{su(Hw)D765N} NA P{su(Hw)L775K} NA P{su(Hw)NoAD2} NA P{su(Hw)NoAD} NA P{su(Hw)Δ100} NA P{su(Hw)Δ283} NA P{su(Hw)ΔA} NA P{su(Hw)ΔB} NA P{su(Hw)ΔC} NA P{su(Hw)ΔCTAD} NA P{su(Hw)wt} NA P{Δ2-203;673-943} NA P{Δ2-203} NA P{Δ656-705} NA P{Δ673-943} NA P{Δ706-736} NA P{Δ738-780} NA P{Δ782-944} NA P{Δ853-880} NA P{Δ881-944} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions ?{}su(Hw)2 NA jockey{}su(Hw)8 NA PBac{RB}su(Hw)e04061 NA
Gene Ontology: Function, Process & Cellular Component ( 10 unique terms )
Terms Based on Experimental Evidence ( 9 terms )
Molecular Function
CV term Evidence References
chromatin insulator sequence binding inferred from direct assay (Kurshakova et al., 2007) DNA binding inferred from mutant phenotype (assigned by UniProtKB) (Harrison et al., 1993) protein binding inferred from physical interaction with mod(mdg4) (assigned by UniProtKB) (Gerasimova et al., 1995) inferred from physical interaction with UniProtKB:Q24478 (assigned by UniProtKB) (Pai et al., 2004) sequence-specific DNA binding inferred from direct assay (Spana et al., 1988)
Biological Process
CV term Evidence References
negative regulation of chromatin silencing inferred from mutant phenotype (Kurshakova et al., 2007) negative regulation of transcription, DNA-dependent inferred from mutant phenotype (Wei and Brennan, 2000) inferred from mutant phenotype (assigned by UniProtKB) (Harrison et al., 1993)
Cellular Component
CV term Evidence References
chromatin inferred from direct assay (Kurshakova et al., 2007) nucleus inferred from direct assay (Kurshakova et al., 2007) inferred from direct assay (assigned by UniProtKB) (Harrison et al., 1993) polytene chromosome inferred from direct assay (Spana et al., 1988)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
DNA binding non-traceable author statement (Swiss-Prot Project Members, 1988.11.1) zinc ion binding inferred from electronic annotation with InterPro:IPR007087, InterPro:IPR015880 (FlyBase Curators et al., 2004-)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
nucleus inferred from sequence or structural similarity with mouse Zfp2 (FlyBase, 1992-) non-traceable author statement (Swiss-Prot Project Members, 1988.11.1)
Sequence Ontology: Class of Gene
	gene_with_edited_transcript (Graveley et al., 2011) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
su(Hw) - CG10077 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) su(Hw) - CG11107 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) su(Hw) - CG11266 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) su(Hw) - CG13472 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) su(Hw) - CG1416 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) su(Hw) - CG1785 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) su(Hw) - CG3689 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) su(Hw) - CG43444 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) su(Hw) - CG4730 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) su(Hw) - CG5746 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) su(Hw) - CG6701 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) su(Hw) - CG6937 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) su(Hw) - CG7878 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) su(Hw) - CG8545 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) su(Hw) - CG8801 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) su(Hw) - CG8939 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) su(Hw) - CG9797 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) su(Hw) - Cdc5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) su(Hw) - Cp1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) su(Hw) - Dp1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) su(Hw) - Fmr1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) su(Hw) - Gale anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) su(Hw) - Imp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) su(Hw) - Jupiter anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) su(Hw) - Mtpα anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) su(Hw) - Ns1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) su(Hw) - Rbp1-like anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) su(Hw) - Rpb8 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) su(Hw) - Rs1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) su(Hw) - SC35 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) su(Hw) - SmG anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) su(Hw) - Syp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) su(Hw) - Thiolase anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) su(Hw) - U4-U6-60K anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) su(Hw) - Zn72D anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) su(Hw) - bol anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) su(Hw) - brm anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) su(Hw) - larp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) su(Hw) - mRpL3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) su(Hw) - mod(mdg4) anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) su(Hw) - nito anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) su(Hw) - nop5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) su(Hw) - qkr58E-3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) su(Hw) - smt3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) su(Hw) - snama anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) su(Hw) - spoon anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions su(Hw) allele Gene References su(Hw)2 abd-A (Busturia et al., 1989, Macias et al., 1990) BEAF-32 (Yamaguchi et al., 2001) Bx (Georgiev and Gerasimova, 1989) ct (Georgiev and Gerasimova, 1989) mod(mdg4) (Georgiev and Kozycina, 1996) r (Zerges et al., 1992, Craymer, 1980) sc (Georgiev and Gerasimova, 1989, Golovnin et al., 1999) y (Georgiev and Gerasimova, 1989, Smith and Corces, 1992, Georgiev and Kozycina, 1996, Georgiev et al., 1997) su(Hw)7 ct (Hoover et al., 1992) r (Zerges et al., 1992) y (Smith and Corces, 1992, Golovnin et al., 2003) su(Hw)8 BEAF-32 (Yamaguchi et al., 2001) mod(mdg4) (Georgiev and Kozycina, 1996) r (Zerges et al., 1992) y (Georgiev and Kozycina, 1996) su(Hw)e2 ct (Dorsett, 1993, Morcillo et al., 1996) Ubx (Dorsett, 1993, Morcillo et al., 1996) su(Hw)E8 y (Harrison et al., 1993) su(Hw)J mod(mdg4) (Georgiev and Kozycina, 1996) sc (Golovnin et al., 1999) y (Gerasimova et al., 1995) su(Hw)L775K y (Gerasimova et al., 1995) su(Hw)NoAD y (Gerasimova et al., 1995) su(Hw)u1 Bx (Georgiev and Gerasimova, 1989) ct (Georgiev and Gerasimova, 1989) sc (Georgiev and Gerasimova, 1989) y (Georgiev and Gerasimova, 1989) su(Hw)u2 Bx (Georgiev and Gerasimova, 1989) ct (Georgiev and Gerasimova, 1989) sc (Georgiev and Gerasimova, 1989) y (Georgiev and Gerasimova, 1989) su(Hw)V ct (Hoover et al., 1992, Melnikova et al., 1996) f (Hoover et al., 1992) w (Parnell and Geyer, 2000) y (Gerasimova et al., 1995, Golovnin et al., 2003) su(Hw)Δ100 mod(mdg4) (Georgiev and Kozycina, 1996) sc (Golovnin et al., 1999) su(Hw)Δ283 sc (Golovnin et al., 1999) y (Gerasimova et al., 1995) su(Hw)ΔA y (Gdula and Corces, 1997) su(Hw)ΔB y (Gdula and Corces, 1997) su(Hw)ΔC y (Gdula and Corces, 1997) su(Hw)ΔCTAD y (Gdula and Corces, 1997) unspecified ac (Lindsley and Grell, 1968) B (Lindsley and Grell, 1968) Chi (Morcillo et al., 1996) ci (Lindsley and Grell, 1968) ct (Lindsley and Grell, 1968) dm (Lindsley and Grell, 1968) f (Lindsley and Grell, 1968) gypsy\su(Hw)BR (Golovnin et al., 1999, Parnell and Geyer, 2000) lz (Lindsley and Grell, 1968) mam (Morcillo et al., 1996) mod(mdg4) (Gdula and Corces, 1997) sc (Lindsley and Grell, 1968, Golovnin et al., 1999) sd (Morcillo et al., 1996) Ubx (Lindsley and Grell, 1968) y (Lindsley and Grell, 1968)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 66816 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0003567 DroID - A comprehensive database of gene and protein interactions. • FBgn0003567 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41740 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • P08970
Orthologs
OrthoDB Orthologs (37) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6VMG0T Dipteran inclusive ortholog search EOG6N04P5 Insect inclusive ortholog search EOG69065K Arthropod inclusive ortholog search EOG6NGF37 Metazoa inclusive ortholog search EOG6B35QT
Orthologs in Drosophila Species (EOG6VMG0T)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\su(Hw)     Drosophila simulans   Dsim\GD20429 Y   Drosophila sechellia   Dsec\GM25860 Y   Drosophila erecta   Dere\GG21375 Y   Drosophila yakuba   Dyak\GE26458 Y   Drosophila ananassae   Dana\su(Hw) Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA21173 Y   Drosophila persimilis   Dper\GL24262 Y   Drosophila willistoni   Dwil\GK11747 Y   Drosophila virilis   Dvir\su(Hw) Y   Drosophila mojavensis   Dmoj\GI21955 Y   Drosophila grimshawi   Dgri\GH22065 Y
Orthologs in non-Drosophila Dipterans (EOG6N04P5)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL002145   Anopheles gambiae Malaria mosquito  Agam\AGAP003111   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ007394
Orthologs in non-Dipteran Insects (EOG69065K)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB44418   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG020275   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH18181   Atta cephalotes Leafcutter ant  Acep\ACEP15894   Atta cephalotes Leafcutter ant  Acep\ACEP15898   Camponotus floridanus Florida carpenter ant  Cflo\CFLO27003   Linepithema humile Argentine ant  Lhum\LH23045   Pogonomyrmex barbatus Red harvester ant  Pbar\PB13398   Solenopsis invicta Red fire ant  Sinv\SINV21795   Acyrthosiphon pisum Pea aphid  Apim\ACYPI009751   Pediculus humanus Human body louse  Phum\PHUM450590   Tribolium castaneum Red flour beetle  Tcas\TC008904
Orthologs in non-Insect Arthropods (EOG6NGF37)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Ixodes scapularis Deer tick  Isca\ISCW001569   Ixodes scapularis Deer tick  Isca\ISCW001573
Orthologs in non-Arthropod Metazoa (EOG6B35QT)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Danio rerio Zebrafish  Drer\CABZ01057951.1   Danio rerio Zebrafish  Drer\ENSDARG00000087255   Mus musculus House mouse  Mmus\Zfp40   Mus musculus House mouse  Mmus\Gm13139   Mus musculus House mouse  Mmus\Gm13251   Mus musculus House mouse  Mmus\Gm13248   Rattus norvegicus Norway rat  Rnor\Zfp40   Homo sapiens Human  Hsap\ZNF726
Human Orthologs (1)
Gene OMIM HGNC Hsap\ZNF726
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD20429 Drosophila sechellia Dsec\GM25860 Drosophila erecta Dere\GG21375 Drosophila yakuba Dyak\GE26458 Drosophila ananassae Dana\su(Hw) Drosophila pseudoobscura pseudoobscura Dpse\GA21173 Drosophila persimilis Dper\GL24262 Drosophila willistoni Dwil\GK11747 Drosophila virilis Dvir\su(Hw) Drosophila mojavensis Dmoj\GI21955 Drosophila grimshawi Dgri\GH22065
Stocks & Reagents
Stocks Listed in FlyBase ( 24 )
Bloomington	672 su(Hw)3/MKRS 9526 w1118; P{hs-su(Hw).GAL4BD}22 1053 y2 sc1 v1; su(Hw)8 33906 y1 sc* v1; P{TRiP.HMS00848}attP2 34006 y1 sc* v1; P{TRiP.HMS00970}attP2 18224 w1118; PBac{RB}su(Hw)e04061/TM6B, Tb1 31600 y1 v1; P{TRiP.JF01189}attP2/TM3, Ser1
Harvard	- PBac{RB}su(Hw)e04061
Kyoto	106033 su(Hw)3/MKRS 106185 y2 sc1 v1; su(Hw)8
VDRC	v100395 P{KK104142}VIE-260B v10724 w1118; P{GD4493}v10724
	More stocks available...
Genomic Clones ( 2 )
	BACR01H04 BACR26A02 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 41 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD15893
Other clones	DPiM_LD15893
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LD12052 LD14402 LD17575 LD20623 LD47370 LP20805 RE05844 RE05980 RE10771 RE16556 RE28415 SD02155
Other clones	57444 66287 76861 98106 107892 148947 153051 178563 CK01.45A.H7 CK01.56D.H7 CK01.109D.E7 CK00517 CK01044 CK01530 Dmel_neb_014350_0945_2319 EC29017 EK045832 EK164507 EK177510 EK194055 EK220563 EK234309 EK244722 EK256263 EK267408 EK283723 IP08967
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0003567 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41740
Antibody Information
	polyclonal (Moshkovich et al., 2011, Matzat et al., 2012, Spana et al., 1988, Baxley et al., 2011, Golovnin et al., 2007, Golovnin et al., 2008, Wallace et al., 2010)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: su(Hw) CG8573 (Zheng, 1999.11)
Source for database merge of
Additional comments
Other Comments
	DNA-protein interactions: genome-wide binding profile assayed for su(Hw) protein in Kc167 cells; see Chromatin_types_NKI collection report. Individual protein-binding experiments listed under "Samples" at GEO_GSE22069 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE22069). (Filion et al., 2010) DNA-protein interactions: genome-wide binding profile assayed for su(Hw) protein in 0-12 hr embryos; see Insulator_Class_II.mE01 collection report. Individual protein-binding experiments listed under "Samples" at GEO: 16245 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE16245). (Nègre et al., 2010) The su(Hw) chromatin insulator protein alters double-strand break repair frequencies in the Drosophila germ line. (Lankenau et al., 2000) Two out of three regions of the su(Hw) protein that are located adjacent to the leucine zipper motif and conserved across Drosophila species are necessary for both unidirectional and bidirectional repression of transcription by su(Hw). Two acidic domains that are dispensable for the unidirectional repression of enhancer elements are critical for the bidirectional silencing of enhancer activity observed in mutants lacking functional mod(mdg4) protein. (Gdula and Corces, 1997) Phenotypic analysis of flies with combinations of mod(mdg4) and su(Hw) mutations suggests that the carboxy-terminal acidic domain of the su(Hw) protein is important for direct inhibition of y transcription in bristles, while the amino-terminal acidic domain is more essential for insulation. (Georgiev and Kozycina, 1996) The roles of each of the 12 zinc fingers of su(Hw) in binding gypsy DNA have been examined and they been classified into four groups: essential (fingers 6 to 10), beneficial but nonessential (fingers 1, 2, 3 and 11), unimportant (fingers 5 and 12), and inhibitory (finger 4). The region between amino acids 737 and 880 contains the residues required for female fertility and the most important domain involved in altering the expression of gypsy element insertion alleles. (Kim et al., 1996) A leucine zipper region of su(Hw) is essential for the repressive effect as well as the enhancement of the y phenotype by mod(mdg4). (Gdula et al., 1995) The repressive effect of su(Hw) on y2 expression is limited to the chromosome in which the su(Hw) binding sites in gypsy are present. The negative effect of the su(Hw) protein can be transmitted to the gene present on the other homologous paired chromosome in the presence of mod(mdg4) mutations. They allow the su(Hw) protein to act in trans and inhibit the action of the y enhancers located in the homologous chromosome on the promoter of their gene. (Georgiev and Corces, 1995) Enhancement of the y phenotype of gypsy-induced alleles by mutations in mod(mdg4) requires an intact su(Hw)-binding region and the su(Hw) protein itself. (Gerasimova et al., 1995) The C terminal portion of the su(Hw) protein is sufficient to block enhancer function of the w reporter gene, blocked enhancer elements are still functional. The su(Hw) protein interrupts the process by which enhancers and promoters communicate with one another to stimulate activated transcription. (Mallin et al., 1995) 22% of recessive lethal mutations caused by the insertion of P{SUPor-P}, which contains gypsy\su(Hw)BR sequences, are suppressed by mutations in su(Hw), indicating that they would not have been detected by a standard P-element insertion. (Roseman et al., 1995) Dosage compensation of autosomally integrated mini-w genes flanked by gypsy\su(Hw)BR sequences is greatly improved compared to insertions not flanked by gypsy\su(Hw)BR, such that complete or nearly complete compensation was observed at the majority of X and autosomal insertion sites. The su(Hw) protein is essential for this enhanced dosage compensation. gypsy\su(Hw)BR may protect the mini-w gene from a negative autosomal chromatin environment. su(Hw) mutations do not affect dosage compensation of the endogenous w gene. (Roseman et al., 1995) su(Hw) acts as a transcriptional activator of gypsy expression during development. Ecol\lacZ reporter gene constructs containing the su(Hw) binding region upstream suggest that su(Hw) activates the tissue-specific expression of gypsy at the level of transcription initiation. Analysis of specific su(Hw) mutant alleles on the expression of this reporter gene indicate that both the amino terminal acidic and the leucine zipper domains of su(Hw) are essential for the proper regulation of gypsy expression in the larval tissues and adult ovaries. This data suggests that the su(Hw) protein interacts with other proteins through its acidic and leucine zipper domains to produce the tissue-specific expression of gypsy. (Smith and Corces, 1995) su(Hw) protein bound to DNA induces a change in DNA structure that is not a directed DNA bend. The DNA distortion requires a domain of the su(Hw) protein that is not required for DNA binding. (Shen et al., 1994) The ct wing phenotype is caused by activation of the wing margin enhancer at pupariation, the su(Hw) gene product is only active when the enhancer is active, thereby blocking the enhancer by binding to gypsy. Enhancer blocking by su(Hw) protein is reversible. (Dorsett, 1993) Interactions between mod(mdg4) and su(Hw) mutations have been studied by their effect on the phenotypic expression of mutations induced by insertion of a gypsy element. (Georgiev and Kozycina, 1993) A structural and functional analysis of the su(Hw) gene product has identified protein domains responsible for its negative effect on enhancer action. su(Hw) is required in females during oogenesis and may be required for decondensation of nurse cell chromosomes. (Harrison et al., 1993) su(Hw) gene product is capable of potentiation of poly(A) sites and enhancer blocking when bound to gypsy inserts. When the su(Hw) gene product is expressed in S.cerevisiae the protein enters the nucleus and binds DNA but only has minor effects on utilization of poly(A) sites. These events therefore require precise interactions with other factors and these either do not have yeast homologs or the homologs are unrecognisable. (Kim et al., 1993) su(Hw) may operate by altering the organization of chromatin creating a new boundary in a preexisting domain of higher order chromatin structure. This separates enhancers and silencers distal to the su(Hw) binding region into an independent unit of gene activity, thereby causing their inactivation. (Roseman et al., 1993) The effects of su(Hw) and mod(mdg4) on a set of y alleles derived in a super-unstable system has been assessed: results suggests that the same regulatory protein may influence gene expression in opposite directions. (Georgiev et al., 1992) DNA bound su(Hw) product interferes with the action of enhancers more distal to but not those more proximal to the y promoter. (Geyer and Corces, 1992) A P element transformation vector developed, named "Y.E.S.", that uses y as the selectable marker and buffers the y coding region from neighbouring enhancers or silencers with su(Hw) binding regions. (Patton et al., 1992) Deletion analysis of gypsy (the insertion into y causing y2) demonstrates that the region to which su(Hw) protein binds is required for the generation of the mutant phenotype by gypsy. (Smith and Corces, 1992) Mutations at su(Hw) found to suppress alleles of r that are not caused by insertions of the gypsy element. Phenotypic suppression correlates with enhanced levels of transcription in these cases. (Zerges et al., 1992) The interaction of su(Hw) protein with its target site in gypsy has been studied. (Spana and Corces, 1990) The su(Hw) gene encodes a protein which activates gypsy transcription. (Mizrokhi et al., 1989) Cloning and characterization of su(Hw) suggests that the gene encodes a DNA-binding protein. The protein may interact with the gypsy element to control its transcription and, as a consequence, its mutagenic effect. su(Hw) gene has been cloned and characterised. (Parkhurst et al., 1988) su(Hw) has been shown to bind specifically to gypsy\su(Hw)BR in vitro. (Spana et al., 1988) In homozygous condition (e.g., su(Hw)2/su(Hw)2 or su(Hw)2/su(Hw)7) suppresses certain spontaneous alleles that contain gypsy inserts at a number of different loci, e.g., y2, acHw-1, sc1, scD2, dm1, ct6, ctK, lz1, f1, f5, fK, B, h1, Ubxbx-3, Ubxbx-34e, bxd, Ubxbxd-51j, Ubxbxd-55i, Ubxbxd-K and ci1; alleles without gypsy inserts are not suppressed (see Lewis, 1949). Apparent exceptions to the above generalizations are scD1, which is suppressed and reportedly X ray induced and rsP1 and rsP2, both of which show temperature-sensitive suppression but no evidence of gypsy insertion. With the exception of lz37, which is enhanced by su(Hw), alleles not known, or known not, to contain gypsy, but which are modified by other suppressors are unaffected by su(Hw). Two alleles, ctK and fK, exhibit suppression in heterozygotes for either su(Hw) or a deficiency for su(Hw). su(Hw) causes accumulation of f transcript in flies carrying f alleles that ordinarily display low levels to return to wild-type levels (Parkhurst and Corces, 1985); judging from results with y2, this is caused by reduction of transcription from the associated gypsy element (Parkhurst and Corces, 1986). Females homozygous for su(Hw)1, su(Hw)2, su(Hw)3 and su(Hw)4 are sterile; females homozygous for su(Hw)8 and transheterozygotes of su(Hw)7 with other alleles are fertile; su(Hw)7/su(Hw)2 are fertile and, in fact, suppress the female sterility of dm and lz (Grell). In sterile combinations, vitellogenesis inhibited leading to smaller-than-normal cysts surrounded by multiple layers of follicle cells; nurse cell chromosomes remain condensed until stage 9, after which egg chambers degenerate; ovarian phenotype autonomous in transplants (Klug et al., 1968; Klug et al., 1970). Reduced viability attributed to some alleles apparently caused by extraneous genes, since those alleles are perfectly viable in combination with su(Hw) deficiencies.
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079625 NM_169574 NM_001260169 RefSeq (Proteins) • NP_524349 NP_731897 NP_001247098 DDBJ / EMBL / GenBank • AA441105 AAF55043 AAF55044 AAO25030 AFH06416 AW942383 BT003273 CAA68371 Y00228 Entrez Gene - A searchable database of RefSeq genes. • 41740 UniProtKB/Swiss-Prot • P08970
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger C2H2-type/integrase DNA-binding domain (IPR013087) Zinc finger, C2H2-like (IPR015880) Zinc finger, C2H2 (IPR007087) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD15893
Linkouts
	BioGRID - A database of protein and genetic interactions • 66816 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0003567 DroID - A comprehensive database of gene and protein interactions. • FBgn0003567 DRSC - Results from RNAi screens. • FBgn0003567 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003567 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8573-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0003567 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41740 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /polycomb/su(hw)1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41740 modMine - Data generated by the modENCODE project. • FBgn0003567 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • P08970
Synonyms & Secondary IDs ( 19 )
Reported As
Symbol Synonym	CG8573 (Klebes et al., 2005, Keleman et al., 2009.8.5, Ni et al., 2008, Ni et al., 2010.12.1) su(HW) (Kai et al., 2005) Su(Hw) (Byrd and Corces, 2003, Geyer and Clark, 2002, Chambeyron and Bickmore, 2004, Pirrotta, 2002, Dorsett et al., 2002, Coveny et al., 2002, Clark et al., 2001, Muller, 2000, Parnell et al., 2000, Torigoi et al., 2000, Mansfield et al., 1994, Melnikova et al., 2006, Kahn et al., 2006, Capelson and Corces, 2005, Akbari et al., 2007, McCluskey et al., 2007, Capelson and Corces, 2006, Pascual et al., 2005, Moon et al., 2005, Ramos et al., 2006, Richter et al., 2011, Kahn et al., 2006, Gause et al., 2001, Georgiev et al., 2008, Levine and Tjian, 2003, Gerasimova et al., 2007, Kurshakova et al., 2007, Kulkarni and Arnosti, 2005, Golovnin et al., 2007, Parnell et al., 2006, Ramos et al., 2011, Erokhin et al., 2011, Bushey et al., 2009, Soshnev et al., 2008, Nègre et al., 2011, Wood et al., 2011, Alic et al., 2011, Mohan et al., 2007, Smith et al., 2009, Golovnin et al., 2008, Kyrchanova et al., 2008, Capelson et al., 2010, Golovnin et al., 2008, Adryan et al., 2007, Rach et al., 2011, Minervini et al., 2010, Nègre et al., 2010, She et al., 2010, Schoborg and Labrador, 2010, Berkaeva et al., 2009, Vorobyeva et al., 2011, Liu et al., 2010, Kostyuchenko et al., 2008, Mel'nik et al., 2004, Gohl et al., 2008, Sakoparnig et al., 2012, Philip et al., 2012, Golovnin et al., 2012, Soshnev et al., 2012) Su(HW) (Cohen et al., 2001) Su(hw) (Marshall, 2003) su(hw) (McVean and Vieira, 1999) su(Hw) (Lee and Wu, 2006, Pai et al., 2004, Gohl et al., 2008, Izutsu et al., 2012, Gause and Georgiev, 2000, Roy et al., 2007, Gerasimova et al., 2000, Wei and Brennan, 2001, Christensen et al., 2008.4.15, Wei and Brennan, 2000, Ivaldi et al., 2007, Baxley et al., 2011, Kravchenko et al., 2005, Savitskaya et al., 2006, Kwong et al., 2008, Weedmark, 2008.10.21, Kalverda and Fornerod, 2010, Jiang et al., 2009, Comet et al., 2011, Gohl et al., 2011, Toku et al., 2011, Comet et al., 2006, Kuhn-Parnell et al., 2008, Gause et al., 2008, Chetverina et al., 2008, Bartkuhn et al., 2009, Xie and Orr-Weaver, 2008, Kostyuchenko et al., 2009, Kurshakova et al., 2007, Li et al., 2008, Jung et al., 2010, Roy et al., 2011, Oliver et al., 2010, Wallace et al., 2010, Erokhin et al., 2010, Karam et al., 2010, Guertin and Lis, 2010, Kostyuchenko et al., 2008, Berger et al., 2012, Japanese National Institute of Genetics, 2012.5.21) SU(HW) (Frydrychova et al., 2007, van Steensel et al., 2010, Filion et al., 2010, van Bemmel et al., 2010, modENCODE Consortium et al., 2010, Vatolina et al., 2011, Vatolina et al., 2011, Demakov et al., 2011) Su[Hw] (Aasland, 1998) SuHw (Wood et al., 2011) suHw (Xu et al., 2004, Li et al., 2008) SUHW (modENCODE Consortium et al., 2010)
Name Synonym	Suppressor of Hair-Wing (Bushey et al., 2009) suppressor of hairy-wing (Chambeyron and Bickmore, 2004) suppressor of Hairy wing (Nègre et al., 2011) Suppressor of Hairy-wing (Pai et al., 2004, Wei and Brennan, 2001, Parnell et al., 2006, Soshnev et al., 2008, Xie and Orr-Weaver, 2008, Soshnev et al., 2012) suppressor of hairy wing (Roy et al., 2007) Suppressor of Hairy wing (Baxley et al., 2011, Golovnin et al., 2008) suppressor of Hairy-wing (Wood et al., 2011)
Secondary FlyBase IDs
	FBgn0015225
References ( 339 )
Generate a list of	All references relating to this gene ( 339 )
List References by type	Research paper  ( 203 ) Supplementary material  ( 6 ) Review  ( 50 ) Personal communication to FlyBase  ( 12 ) Abstract  ( 55 ) FlyBase analysis  ( 1 ) Note  ( 1 ) Stock list  ( 1 ) Curated genome annotation  ( 3 ) Protein sequence record  ( 1 ) Website  ( 1 ) Book  ( 3 ) Conference report  ( 1 )
Recent research papers ( 29 )
	Lim et al., 2013, Nucleic Acids Res. 41(5): 2963--2980 Genome-wide localization of exosome components to active promoters and chromatin insulators in Drosophila. [FBrf0221054] Baradaran-Heravi et al., 2012, Hum. Mol. Genet. 21(11): 2572--2587 Penetrance of biallelic SMARCAL1 mutations is associated with environmental and genetic disturbances of gene expression. [FBrf0218299] Berger et al., 2012, Cell Rep. 2(2): 407--418 FACS Purification and Transcriptome Analysis of Drosophila Neural Stem Cells Reveals a Role for Klumpfuss in Self-Renewal. [FBrf0219320] Crawford et al., 2012, Cell Death Differ. 19(12): 2040--2048 Conservation of caspase substrates across metazoans suggests hierarchical importance of signaling pathways over specific targets and cleavage site motifs in apoptosis. [FBrf0220233] Golovnin et al., 2012, J. Cell Sci. 125(8): 2064--2074 SUMO conjugation is required for the assembly of Drosophila Su(Hw) and Mod(mdg4) into insulator bodies that facilitate insulator complex formation. [FBrf0218398] Izutsu et al., 2012, PLoS ONE 7(3): e33288 Genome features of "dark-fly", a Drosophila line reared long-term in a dark environment. [FBrf0217825] Matzat et al., 2012, PLoS Genet. 8(11): e1003069 Tissue-specific regulation of chromatin insulator function. [FBrf0220170] Philip et al., 2012, BMC Genomics 13(1): 97 Sequence signatures involved in targeting the male-specific lethal complex to X-chromosomal genes in Drosophila melanogaster. [FBrf0218340] Riddle et al., 2012, PLoS Genet. 8(9): e1002954 Enrichment of HP1a on Drosophila Chromosome 4 Genes Creates an Alternate Chromatin Structure Critical for Regulation in this Heterochromatic Domain. [FBrf0219520] Sakoparnig et al., 2012, J. Comput. Biol. 19(2): 126--138 Binding profiles of chromatin-modifying proteins are predictive for transcriptional activity and promoter-proximal pausing. [FBrf0217402] Schwartz et al., 2012, Genome Res. 22(11): 2188--2198 Nature and function of insulator protein binding sites in the Drosophila genome. [FBrf0219925] Soshnev et al., 2012, Nucleic Acids Res. 40(12): 5415--5431 Genome-wide studies of the multi-zinc finger Drosophila Suppressor of Hairy-wing protein in the ovary. [FBrf0218724] Alic et al., 2011, Mol. Syst. Biol. 7: 502 Genome-wide dFOXO targets and topology of the transcriptomic response to stress and insulin signalling. [FBrf0214014] Baxley et al., 2011, Dev. Biol. 356(2): 398--410 The role of the Suppressor of Hairy-wing insulator protein in Drosophila oogenesis. [FBrf0214454] Comet et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(6): 2294--2299 A chromatin insulator driving three-dimensional Polycomb response element (PRE) contacts and Polycomb association with the chromatin fiber. [FBrf0213029] Demakov et al., 2011, BMC Genomics 12: 566 Protein composition of interband regions in polytene and cell line chromosomes of Drosophila melanogaster. [FBrf0216974] Erokhin et al., 2011, Development 138(18): 4097--4106 Insulators form gene loops by interacting with promoters in Drosophila. [FBrf0214806] Gohl et al., 2011, Genetics 187(3): 731--748 Mechanism of chromosomal boundary action: roadblock, sink, or loop? [FBrf0214438] Moshkovich et al., 2011, Genes Dev. 25(16): 1686--1701 RNAi-independent role for Argonaute2 in CTCF/CP190 chromatin insulator function. [FBrf0214686] Nègre et al., 2011, Nature 471(7339): 527--531 A cis-regulatory map of the Drosophila genome. [FBrf0213303] Rach et al., 2011, PLoS Genet. 7(1): e1001274 Transcription initiation patterns indicate divergent strategies for gene regulation at the chromatin level. [FBrf0214353] Ramos et al., 2011, PLoS ONE 6(1): e16562 DNA Topoisomerase II Modulates Insulator Function in Drosophila. [FBrf0213027] Richter et al., 2011, Nat. Cell Biol. 13(9): 1029--1039 The tumour suppressor L(3)mbt inhibits neuroepithelial proliferation and acts on insulator elements. [FBrf0215050] Roy et al., 2011, Mol. Genet. Genomics 285(2): 113--123 Lack of the Drosophila BEAF insulator proteins alters regulation of genes in the Antennapedia complex. [FBrf0212912] Toku et al., 2011, Comput. Biol. Chem. 35(5): 282--292 Reconstruction and crosstalk of protein-protein interaction networks of Wnt and Hedgehog signaling in Drosophila melanogaster. [FBrf0216393] Vatolina et al., 2011, Genetika, Moscow 47(5): 597--609 [Identification and molecular genetic characterization of the polytene chromosome interbands in Drosophila melanogaster]. [FBrf0214456] Vatolina et al., 2011, Russ. J. Genet. 47(5): 521--532 Identification and molecular genetic characterization of the polytene chromosome interbands in Drosophila melanogaster. [FBrf0216692] Vorobyeva et al., 2011, Cell Cycle 10(11): 1821--1827 SAYP interacts with DHR3 nuclear receptor and participates in ecdysone-dependent transcription regulation. [FBrf0213948] Wood et al., 2011, Mol. Cell 44(1): 29--38 Regulation of chromatin organization and inducible gene expression by a Drosophila insulator. [FBrf0216321] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...