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General Information
Symbol
Dmel\su(Hw)
Species
D. melanogaster
Name
suppressor of Hairy wing
Annotation Symbol
CG8573
Feature Type
FlyBase ID
FBgn0003567
Gene Model Status
Stock Availability
Gene Snapshot
Also Known As

suHw

Key Links
Genomic Location
Cytogenetic map
Sequence location
3R:14,304,455..14,308,589 [-]
Recombination map

3-55

RefSeq locus
NT_033777 REGION:14304455..14308589
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (12 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
inferred from direct assay
inferred from mutant phenotype
(assigned by UniProt )
inferred from direct assay
inferred from physical interaction with UniProtKB:Q9V8P9
(assigned by UniProt )
inferred from physical interaction with UniProtKB:Q86B87
(assigned by UniProt )
inferred from physical interaction with UniProtKB:Q24478
(assigned by UniProt )
inferred from physical interaction with UniProtKB:Q9VCH5
(assigned by UniProt )
inferred from physical interaction with UniProtKB:Q9VYX1
(assigned by UniProt )
Terms Based on Predictions or Assertions (0 terms)
Biological Process (4 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
inferred from mutant phenotype
(assigned by UniProt )
inferred from mutant phenotype
inferred from direct assay
(assigned by UniProt )
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
inferred from direct assay
inferred from direct assay
(assigned by UniProt )
inferred from direct assay
inferred from direct assay
Terms Based on Predictions or Assertions (0 terms)
Protein Family (UniProt)
-
Summaries
Gene Group (FlyBase)
C2H2 ZINC FINGER TRANSCRIPTION FACTORS -
Zinc finger C2H2 transcription factors are sequence-specific DNA binding proteins that regulate transcription. They possess DNA-binding domains that are formed from repeated Cys2His2 zinc finger motifs. (Adapted from PMID:1835093, FBrf0220103 and FBrf0155739).
Protein Function (UniProtKB)
Component of the gypsy chromatin insulator complex which is required for the function of the gypsy chromatin insulator and other endogenous chromatin insulators. Chromatin insulators are regulatory elements which establish independent domains of transcriptional activity within eukaryotic genomes. Insulators have two defining properties; they can block the communication between an enhancer and a promoter when placed between them and can also buffer transgenes from position effect variegation (PEV). Insulators are proposed to structure the chromatin fiber into independent domains of differing transcriptional potential by promoting the formation of distinct chromatin loops. This chromatin looping may involve the formation of insulator bodies, where homotypic interactions between individual subunits of the insulator complex could promote the clustering of widely spaced insulators at the nuclear periphery. Within the gypsy insulator complex, this protein binds specifically to a region of the gypsy element located 3' of the 5' long terminal repeat (LTR), and may also mediate interaction with other endogenous insulators at sites distinct from those recognized by Cp190.
(UniProt, P08970)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
su(Hw): suppressor of Hairy wing
In homozygous condition (e.g., su(Hw)2/su(Hw)2 or su(Hw)2/su(Hw)7) suppresses certain spontaneous alleles that contain gypsy inserts at a number of different loci, e.g., y2, Hw1, sc1, scD2, dm1, ct6, ctK, lz1, f1, f5, fK, B, Bxd2, h1, bx3, bx34e, bxd, bxd51j, bxd55i, bxdK, and ci1; alleles without gypsy inserts are not suppressed (see Lewis, 1949). Apparent exceptions to the above generalizations are scD1, which is suppressed and reportedly X ray induced and rsP1 and rsP2, both of which show temperature-sensitive suppression but no evidence of gypsy insertion. With the exception of lz37, which is enhanced by su(Hw), alleles not known, or known not, to contain gypsy, but which are modified by other suppressors are unaffected by su(Hw). Two alleles, ctK and fK, exhibit suppression in heterozygotes for either su(Hw) or a deficiency for su(Hw). su(Hw) causes accumulation of f transcript in flies carrying f alleles that ordinarily display low levels to return to wild-type levels (Parkhurst and Corces, 1985, Cell 41: 429-37); judging from results with y2, this is caused by reduction of transcription from the associated gypsy element (Parkhurst and Corces, 1986, Mol. Cell. Biol. 6: 47-53). Females homozygous for su(Hw)1, su(Hw)2, su(Hw)3, and su(Hw)4 are sterile; females homozygous for su(Hw)8 and transheterozygotes of su(Hw)7 with other allelles are fertile; su(Hw)7/su(Hw)2 are fertile and, in fact, suppress the female sterility of dm and lz (Grell). In sterile combinations, vitellogenesis inhibited leading to smaller-than-normal cysts surrounded by multiple layers of follicle cells; nurse cell chromosomes remain condensed until stage 9, after which egg chambers degenerate; ovarian phenotype autonomous in transplants (Klug et al., 1968, 1970). Reduced viability attributed to some alleles apparently caused by extraneous genes, since those alleles are perfectly viable in combination with su(Hw) deficiencies.
Summary (Interactive Fly)

transcription factor - zinc finger - insulator protein - blocks enhancer-promoter interactions - required for proper ring canal development during oogenesis

Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\su(Hw) or the JBrowse view of Dmel\su(Hw) for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.41

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.53

Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0082946
3260
941
FBtr0082945
3508
941
FBtr0310002
3682
941
Additional Transcript Data and Comments
Reported size (kB)

3.3 (northern blot)

Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0082405
105.8
941
6.70
FBpp0082404
105.8
941
6.70
FBpp0301708
105.8
941
6.70
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

941 aa isoforms: su(Hw)-PA, su(Hw)-PB, su(Hw)-PC
Additional Polypeptide Data and Comments
Reported size (kDa)

944 (aa); 109 (kD)

Comments
External Data
Subunit Structure (UniProtKB)

Component of the gypsy chromatin insulator complex, composed of Cp190, mod(mdg4) and su(Hw) (PubMed:7664338, PubMed:11350941, PubMed:11416154, PubMed:15574329). The gypsy chromatin insulator complex interacts with Topors via mod(mdg4) and su(Hw) (PubMed:16209949). Upon ecdysone stimulation, interacts with Nup98 (PubMed:28366641).

(UniProt, P08970)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\su(Hw) using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
organism

Comment: maternally deposited

antennal anlage

Comment: reported as procephalic ectoderm anlage

central brain anlage

Comment: reported as procephalic ectoderm anlage

dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

visual anlage

Comment: reported as procephalic ectoderm anlage

northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data

su(Hw) transcripts are expressed throughout development and in ovaries.

The su(Hw) transcript is nearly absent in su(Hw)8 ovaries.

Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data

su(Hw) protein is detected in the nucleus of all cells.

levels in the GSCs and daughter cystoblasts and is absent in regions of the germarium where the 16-cell cyst is formed and meiosis is initiated (regions 1 and 2a). su(Hw) reappears in region 2b and increases during egg chamber formation.

su(Hw) is present in all somatic cells within the germarium. It is present at low levels in germline stem cells and is absent in mitotically active germ cells in region 2. su(Hw) accumulation increases in region 3, with protein localized to nurse cell chromosomes, but excluded from the oocyte nucleus. It remains assoicated with nurse cell chromosomes to late stages of oogenesis.

su(Hw) protein is a ubiquitous nuclear protein detected in all developmental stages and in both sexes.

Marker for
 
Subcellular Localization
CV Term
Evidence
References
inferred from direct assay
inferred from direct assay
(assigned by UniProt )
inferred from direct assay
inferred from direct assay
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\su(Hw) in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 26 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 61 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of su(Hw)
Transgenic constructs containing regulatory region of su(Hw)
Deletions and Duplications ( 23 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (24)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
2 of 15
Yes
Yes
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
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Yes
1 of 15
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No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
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Yes
1 of 15
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Yes
1 of 15
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Yes
1 of 15
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No
1 of 15
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No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (18)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
1 of 15
Yes
Yes
1 of 15
Yes
Yes
1 of 15
Yes
Yes
1 of 15
Yes
Yes
1 of 15
Yes
Yes
1 of 15
Yes
Yes
1 of 15
Yes
Yes
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No
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Yes
No
1 of 15
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Yes
1 of 15
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Yes
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Yes
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Yes
Yes
1 of 15
Yes
No
1 of 15
Yes
Yes
1 of 15
Yes
No
1 of 15
Yes
Yes
1 of 15
Yes
Yes
Rattus norvegicus (Norway rat) (15)
1 of 13
Yes
Yes
1 of 13
Yes
Yes
1 of 13
Yes
Yes
1 of 13
Yes
Yes
1 of 13
Yes
Yes
1 of 13
Yes
Yes
1 of 13
Yes
Yes
1 of 13
Yes
No
1 of 13
Yes
No
1 of 13
Yes
Yes
1 of 13
Yes
Yes
1 of 13
Yes
Yes
1 of 13
Yes
No
1 of 13
Yes
Yes
1 of 13
Yes
Yes
Xenopus tropicalis (Western clawed frog) (5)
1 of 12
Yes
No
1 of 12
Yes
Yes
1 of 12
Yes
Yes
1 of 12
Yes
No
1 of 12
Yes
Yes
Danio rerio (Zebrafish) (27)
1 of 15
Yes
Yes
1 of 15
Yes
Yes
1 of 15
Yes
No
1 of 15
Yes
Yes
1 of 15
Yes
Yes
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Yes
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Yes
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Yes
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Yes
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Yes
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Yes
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Yes
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Yes
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Yes
Yes
1 of 15
Yes
No
1 of 15
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (7)
1 of 15
Yes
Yes
1 of 15
Yes
No
1 of 15
Yes
Yes
1 of 15
Yes
No
1 of 15
Yes
Yes
1 of 15
Yes
No
1 of 15
Yes
No
Arabidopsis thaliana (thale-cress) (2)
1 of 9
Yes
No
1 of 9
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (3)
1 of 15
Yes
No
1 of 15
Yes
Yes
1 of 15
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091903U0 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091501AH )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W04J7 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X04FP )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Ixodes scapularis
Black-legged tick
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G02KC )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Ciona intestinalis
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Gallus gallus
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Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (49)
2 of 10
2 of 10
2 of 10
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2 of 10
2 of 10
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Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
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    OMIM
    OMIM Phenotype
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    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
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    Please see the Physical Interaction reports below for full details
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    protein-protein
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    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
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    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
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    Starting gene(s)
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    External Data
    Subunit Structure (UniProtKB)
    Component of the gypsy chromatin insulator complex, composed of Cp190, mod(mdg4) and su(Hw) (PubMed:7664338, PubMed:11350941, PubMed:11416154, PubMed:15574329). The gypsy chromatin insulator complex interacts with Topors via mod(mdg4) and su(Hw) (PubMed:16209949). Upon ecdysone stimulation, interacts with Nup98 (PubMed:28366641).
    (UniProt, P08970 )
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
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    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3R
    Recombination map

    3-55

    Cytogenetic map
    Sequence location
    3R:14,304,455..14,308,589 [-]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    88B3-88B3
    Limits computationally determined from genome sequence between P{lacW}trxj14A6&P{PZ}trx00347 and P{PZ}cv-c06951
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    88B-88C
    (determined by in situ hybridisation)
    Experimentally Determined Recombination Data
    Left of (cM)
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    Stocks and Reagents
    Stocks (26)
    Genomic Clones (15)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (41)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    RNAi and Array Information
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    DRSC - Results frm RNAi screens
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Antibody Information
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    Relationship to Other Genes
    Source for database identify of

    Source for identity of: su(Hw) CG8573

    Source for database merge of
    Additional comments
    Other Comments

    The insulator and fertility functions of su(Hw) are genetically separable.

    DNA-protein interactions: genome-wide binding profile assayed for su(Hw) protein in Kc167 cells; see Chromatin_types_NKI collection report. Individual protein-binding experiments listed under "Samples" at GEO_GSE22069 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE22069).

    DNA-protein interactions: genome-wide binding profile assayed for su(Hw) protein in 0-12 hr embryos; see Insulator_Class_II.mE01 collection report. Individual protein-binding experiments listed under "Samples" at GEO: 16245 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE16245).

    The su(Hw) chromatin insulator protein alters double-strand break repair frequencies in the Drosophila germ line.

    Two out of three regions of the su(Hw) protein that are located adjacent to the leucine zipper motif and conserved across Drosophila species are necessary for both unidirectional and bidirectional repression of transcription by su(Hw). Two acidic domains that are dispensable for the unidirectional repression of enhancer elements are critical for the bidirectional silencing of enhancer activity observed in mutants lacking functional mod(mdg4) protein.

    Phenotypic analysis of flies with combinations of mod(mdg4) and su(Hw) mutations suggests that the carboxy-terminal acidic domain of the su(Hw) protein is important for direct inhibition of y transcription in bristles, while the amino-terminal acidic domain is more essential for insulation.

    The roles of each of the 12 zinc fingers of su(Hw) in binding gypsy DNA have been examined and they been classified into four groups: essential (fingers 6 to 10), beneficial but nonessential (fingers 1, 2, 3 and 11), unimportant (fingers 5 and 12), and inhibitory (finger 4). The region between amino acids 737 and 880 contains the residues required for female fertility and the most important domain involved in altering the expression of gypsy element insertion alleles.

    A leucine zipper region of su(Hw) is essential for the repressive effect as well as the enhancement of the y phenotype by mod(mdg4).

    The repressive effect of su(Hw) on y2 expression is limited to the chromosome in which the su(Hw) binding sites in gypsy are present. The negative effect of the su(Hw) protein can be transmitted to the gene present on the other homologous paired chromosome in the presence of mod(mdg4) mutations. They allow the su(Hw) protein to act in trans and inhibit the action of the y enhancers located in the homologous chromosome on the promoter of their gene.

    Enhancement of the y phenotype of gypsy-induced alleles by mutations in mod(mdg4) requires an intact su(Hw)-binding region and the su(Hw) protein itself.

    The C terminal portion of the su(Hw) protein is sufficient to block enhancer function of the w reporter gene, blocked enhancer elements are still functional. The su(Hw) protein interrupts the process by which enhancers and promoters communicate with one another to stimulate activated transcription.

    Dosage compensation of autosomally integrated mini-w genes flanked by gypsy\su(Hw)BR sequences is greatly improved compared to insertions not flanked by gypsy\su(Hw)BR, such that complete or nearly complete compensation was observed at the majority of X and autosomal insertion sites. The su(Hw) protein is essential for this enhanced dosage compensation. gypsy\su(Hw)BR may protect the mini-w gene from a negative autosomal chromatin environment. su(Hw) mutations do not affect dosage compensation of the endogenous w gene.

    22% of recessive lethal mutations caused by the insertion of P{SUPor-P}, which contains gypsy\su(Hw)BR sequences, are suppressed by mutations in su(Hw), indicating that they would not have been detected by a standard P-element insertion.

    su(Hw) acts as a transcriptional activator of gypsy expression during development. Ecol\lacZ reporter gene constructs containing the su(Hw) binding region upstream suggest that su(Hw) activates the tissue-specific expression of gypsy at the level of transcription initiation. Analysis of specific su(Hw) mutant alleles on the expression of this reporter gene indicate that both the amino terminal acidic and the leucine zipper domains of su(Hw) are essential for the proper regulation of gypsy expression in the larval tissues and adult ovaries. This data suggests that the su(Hw) protein interacts with other proteins through its acidic and leucine zipper domains to produce the tissue-specific expression of gypsy.

    su(Hw) protein bound to DNA induces a change in DNA structure that is not a directed DNA bend. The DNA distortion requires a domain of the su(Hw) protein that is not required for DNA binding.

    The ct wing phenotype is caused by activation of the wing margin enhancer at pupariation, the su(Hw) gene product is only active when the enhancer is active, thereby blocking the enhancer by binding to gypsy. Enhancer blocking by su(Hw) protein is reversible.

    Interactions between mod(mdg4) and su(Hw) mutations have been studied by their effect on the phenotypic expression of mutations induced by insertion of a gypsy element.

    A structural and functional analysis of the su(Hw) gene product has identified protein domains responsible for its negative effect on enhancer action. su(Hw) is required in females during oogenesis and may be required for decondensation of nurse cell chromosomes.

    su(Hw) gene product is capable of potentiation of poly(A) sites and enhancer blocking when bound to gypsy inserts. When the su(Hw) gene product is expressed in S.cerevisiae the protein enters the nucleus and binds DNA but only has minor effects on utilization of poly(A) sites. These events therefore require precise interactions with other factors and these either do not have yeast homologs or the homologs are unrecognisable.

    su(Hw) may operate by altering the organization of chromatin creating a new boundary in a preexisting domain of higher order chromatin structure. This separates enhancers and silencers distal to the su(Hw) binding region into an independent unit of gene activity, thereby causing their inactivation.

    The effects of su(Hw) and mod(mdg4) on a set of y alleles derived in a super-unstable system has been assessed: results suggests that the same regulatory protein may influence gene expression in opposite directions.

    DNA bound su(Hw) product interferes with the action of enhancers more distal to but not those more proximal to the y promoter.

    A P element transformation vector developed, named "Y.E.S.", that uses y as the selectable marker and buffers the y coding region from neighbouring enhancers or silencers with su(Hw) binding regions.

    Deletion analysis of gypsy (the insertion into y causing y2) demonstrates that the region to which su(Hw) protein binds is required for the generation of the mutant phenotype by gypsy.

    Mutations at su(Hw) found to suppress alleles of r that are not caused by insertions of the gypsy element. Phenotypic suppression correlates with enhanced levels of transcription in these cases.

    The interaction of su(Hw) protein with its target site in gypsy has been studied.

    The su(Hw) gene encodes a protein which activates gypsy transcription.

    Cloning and characterization of su(Hw) suggests that the gene encodes a DNA-binding protein. The protein may interact with the gypsy element to control its transcription and, as a consequence, its mutagenic effect. su(Hw) gene has been cloned and characterised.

    su(Hw) has been shown to bind specifically to gypsy\su(Hw)BR in vitro.

    In homozygous condition (e.g., su(Hw)2/su(Hw)2 or su(Hw)2/su(Hw)7) suppresses certain spontaneous alleles that contain gypsy inserts at a number of different loci, e.g., y2, acHw-1, sc1, scD2, dm1, ct6, ctK, lz1, f1, f5, fK, B, h1, Ubxbx-3, Ubxbx-34e, bxd, Ubxbxd-51j, Ubxbxd-55i, Ubxbxd-K and ci1; alleles without gypsy inserts are not suppressed (see Lewis, 1949). Apparent exceptions to the above generalizations are scD1, which is suppressed and reportedly X ray induced and rsP1 and rsP2, both of which show temperature-sensitive suppression but no evidence of gypsy insertion. With the exception of lz37, which is enhanced by su(Hw), alleles not known, or known not, to contain gypsy, but which are modified by other suppressors are unaffected by su(Hw). Two alleles, ctK and fK, exhibit suppression in heterozygotes for either su(Hw) or a deficiency for su(Hw). su(Hw) causes accumulation of f transcript in flies carrying f alleles that ordinarily display low levels to return to wild-type levels (Parkhurst and Corces, 1985); judging from results with y2, this is caused by reduction of transcription from the associated gypsy element (Parkhurst and Corces, 1986). Females homozygous for su(Hw)1, su(Hw)2, su(Hw)3 and su(Hw)4 are sterile; females homozygous for su(Hw)8 and transheterozygotes of su(Hw)7 with other alleles are fertile; su(Hw)7/su(Hw)2 are fertile and, in fact, suppress the female sterility of dm and lz (Grell). In sterile combinations, vitellogenesis inhibited leading to smaller-than-normal cysts surrounded by multiple layers of follicle cells; nurse cell chromosomes remain condensed until stage 9, after which egg chambers degenerate; ovarian phenotype autonomous in transplants (Klug et al., 1968; Klug et al., 1970). Reduced viability attributed to some alleles apparently caused by extraneous genes, since those alleles are perfectly viable in combination with su(Hw) deficiencies.

    Origin and Etymology
    Discoverer
    Etymology
    Identification
    External Crossreferences and Linkouts ( 42 )
    Sequence Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
    Other crossreferences
    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    Flygut - An atlas of the Drosophila adult midgut
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
    InterPro - A database of protein families, domains and functional sites
    KEGG Genes - Molecular building blocks of life in the genomic space.
    modMine - A data warehouse for the modENCODE project
    SignaLink - A signaling pathway resource with multi-layered regulatory networks.
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DPiM - Drosophila Protein interaction map
    DroID - A comprehensive database of gene and protein interactions.
    DRSC - Results frm RNAi screens
    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
    FlyMine - An integrated database for Drosophila genomics
    Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Synonyms and Secondary IDs (19)
    Reported As
    Symbol Synonym
    Su(Hw)
    (Arzate-Mejía et al., 2020, Dong et al., 2020, Bag et al., 2019, Chen and Lei, 2019, Chen et al., 2019, Kostyuchenko et al., 2019, Melnikova et al., 2019, Melnikova et al., 2019, Vorobyeva and Mazina, 2019, Fedoseeva et al., 2018, Maksimenko et al., 2018, Melnikova et al., 2018, Melnikova et al., 2018, Mourad and Cuvier, 2018, Wang et al., 2018, El-Sharnouby et al., 2017, Gerland et al., 2017, Kravchuk et al., 2017, Lomaev et al., 2017, Mourad et al., 2017, Pascual-Garcia et al., 2017, Golovnin et al., 2016, Guida et al., 2016, Kwon et al., 2016, Kyrchanova et al., 2016, Savitsky et al., 2016, Xu et al., 2016, Golovnin et al., 2015, Hsu et al., 2015, Li et al., 2015, Magbanua et al., 2015, Maksimenko et al., 2015, Nikalayevich and Ohkura, 2015, Wolle et al., 2015, Alekseyenko et al., 2014, Comoglio and Paro, 2014, Cuartero et al., 2014, Dale et al., 2014, Jiang and Singh, 2014, Korenjak et al., 2014, Kyrchanova and Georgiev, 2014, Matzat and Lei, 2014, McElroy et al., 2014, Rhee et al., 2014, Van Bortle et al., 2014, Fedoseeva and Tchurikov, 2013, Gurudatta et al., 2013, Kellner et al., 2013, Li and Zhou, 2013, Matzat et al., 2013, Ong et al., 2013, Rohrbaugh et al., 2013, Rubin and Green, 2013, Soshnev et al., 2013, Golovnin et al., 2012, Hou et al., 2012, Matzat et al., 2012, McKee et al., 2012, Philip et al., 2012, Sakoparnig et al., 2012, Soshnev et al., 2012, Stefanov et al., 2012, Van Bortle et al., 2012, Alic et al., 2011, Erokhin et al., 2011, Nègre et al., 2011, Rach et al., 2011, Ramos et al., 2011, Richter et al., 2011, Vogelmann et al., 2011, Vorobyeva et al., 2011, Wood et al., 2011, Capelson et al., 2010, Erokhin et al., 2010, Liu et al., 2010, Minervini et al., 2010, Nègre et al., 2010, Schoborg and Labrador, 2010, She et al., 2010, Berkaeva et al., 2009, Bushey et al., 2009, Smith et al., 2009, Georgiev et al., 2008, Gohl et al., 2008, Golovnin et al., 2008, Golovnin et al., 2008, Kostyuchenko et al., 2008, Kyrchanova et al., 2008, Soshnev et al., 2008, Adryan et al., 2007, Akbari et al., 2007, Gerasimova et al., 2007, Golovnin et al., 2007, Kurshakova et al., 2007, McCluskey et al., 2007, Mohan et al., 2007, Capelson and Corces, 2006, Kahn et al., 2006, Kahn et al., 2006, Lei and Corces, 2006, Melnikova et al., 2006, Parnell et al., 2006, Ramos et al., 2006, Capelson and Corces, 2005, Kulkarni and Arnosti, 2005, Moon et al., 2005, Pascual et al., 2005, Chambeyron and Bickmore, 2004, Mel'nik et al., 2004, Byrd and Corces, 2003, Levine and Tjian, 2003, Coveny et al., 2002, Dorsett et al., 2002, Geyer and Clark, 2002, Pirrotta, 2002, Clark et al., 2001, Gause et al., 2001, Muller, 2000, Parnell et al., 2000, Torigoi et al., 2000, Mansfield et al., 1994)
    su(Hw)
    (Hinnant et al., 2020, Glenn and Geyer, 2019, Kyrchanova et al., 2019, Luzhin et al., 2019, Melnikova et al., 2019, Meltzer et al., 2019, Piwko et al., 2019, Radion et al., 2019, Shokri et al., 2019, Baldi et al., 2018, Cho et al., 2018, Baxley et al., 2017, Chen et al., 2017, Ciabrelli et al., 2017, Melnikova et al., 2017, Melnikova et al., 2017, Kahn et al., 2016, Lo et al., 2016, Lu et al., 2016, Ulianov et al., 2016, model organism Encyclopedia of Regulatory Network (modERN) Project, 2015-, Boyle et al., 2014, Slattery et al., 2014, Kyrchanova et al., 2013, Matzat et al., 2013, Schoborg et al., 2013, Thomae et al., 2013, Berger et al., 2012, Izutsu et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Matzat et al., 2012, Stefanov et al., 2012, Baxley et al., 2011, Comet et al., 2011, Gohl et al., 2011, Roy et al., 2011, Toku et al., 2011, Bulger and Groudine, 2010, Erokhin et al., 2010, Guertin and Lis, 2010, Jung et al., 2010, Kalverda and Fornerod, 2010, Karam et al., 2010, Krivega et al., 2010, Oliver et al., 2010, Wallace et al., 2010, Bartkuhn et al., 2009, Jiang et al., 2009, Kostyuchenko et al., 2009, Chetverina et al., 2008, Christensen et al., 2008.4.15, Gause et al., 2008, Gohl et al., 2008, Kostyuchenko et al., 2008, Kuhn-Parnell et al., 2008, Kwong et al., 2008, Li et al., 2008, Weedmark, 2008.10.21, Xie and Orr-Weaver, 2008, Ivaldi et al., 2007, Kurshakova et al., 2007, Roy et al., 2007, Comet et al., 2006, Lee and Wu, 2006, Savitskaya et al., 2006, Kravchenko et al., 2005, Pai et al., 2004, Wei and Brennan, 2001, Gause and Georgiev, 2000, Gerasimova et al., 2000, Wei and Brennan, 2000)
    Secondary FlyBase IDs
    • FBgn0015225
    Datasets (6)
    Study focus (6)
    Experimental Role
    Project
    Project Type
    Title
    • transgene_used
    The insulator protein SU(HW) modulates nuclear lamina interactions of the Drosophila genome.
    • transgene_used
    Protein profiling reveals five principal chromatin types in Drosophila cells.
    • RNAi_target
    Genome-wide localization of chromosomal proteins in cell lines by ChIP-chip and ChIP-Seq.
    • bait_protein
    Genome-wide localization of chromosomal proteins in fly tissues by ChIP-chip and ChIP-Seq.
    • RNAi_target
    Genome-wide localization of histones and their modifications in cell lines by ChIP-chip and ChIP-Seq.
    • bait_protein
    Genome-wide localization of insulator proteins by ChIP-chip and ChIP-Seq.
    References (461)