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Gene Dmel\su(s)

General Information
Symbol	Dmel\su(s)	Species	D. melanogaster
Name	suppressor of sable	Annotation symbol	CG6222
Feature type	protein_coding_gene	FlyBase ID	FBgn0003575
Gene Model Status	Current	Stock availability	13 publicly available
Also Known As	EG:115C2.3, su-s
Genomic Location
Chromosome (arm)	X	Recombination map	1-0+
Cytogenetic map	1B13-1B13	Sequence location	X:529,923..537,793 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene suppressor of sable is referred to in FlyBase by the symbol Dmel\su(s) (CG6222, FBgn0003575). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: RNA binding. There is experimental evidence that it is involved in the biological process: nuclear RNA surveillance. 153 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; mesothoracic tergum. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Zinc finger, CCCH-type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, during early pupal stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, adult crop, larval hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1626259_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of su(s). Gene sequence location is X:529923..537793.
User Contributed Data
	Beta version, feedback welcome
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	su(s): suppressor of sable (R.A. Voelker) In hemizygous or homozygous condition suppresses certain spontaneous alleles that contain 412 insertions at several loci (e.g., v, v2, vk, pr, prbw, sp) or hybrid dysgenesis-induced alleles that contain P element insertions (e.g., snw, y76d28). s is suppressible but does not have a 412 insertion (Searles and Voelker, 1986). bx is caused by a 412 insertion but is not suppressed (Voelker et al., 1989). Not all su(s) alleles suppress all suppressible alleles (Jacobson et al., 1982a). Although reported as recessive, some alleles show a slight dominance (Shapard, 1960; Baglioni, 1960). No lethal alleles recovered in a lethal saturation screen of the su(s) region, but a number of X-ray-, EMS- and ENU-induced alleles exhibit sterility or reduced male fertility when reared at 18C (Voelker et al., 1989). Some alleles cause a slight spreading of the wings, especially in males. Suppression of v and y76d28 occurs by elevating the levels of pseudo-wild-type, presumably translatable, message (Searles, Ruth, Pret, Fridell, and Ali, submitted; P. Geyer, V. Corces and M. Green, personal communication). Some alleles enhance some gypsy-caused mutations (Rutledge et al., 1988). A duplication of su(s)+ enhances suppressible pr alleles (Jacobson et al., 1982b).
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 1B13-1B13   Limits computationally determined from genome sequence between P{EP}DreddEP1412&P{EP}Suv4-20EP1216a and P{EP}sdkEP369
Experimentally Determined Cytological Location
Cytogenetic map Notes References 1B13-1C1   (determined by in situ hybridisation)   (Voelker et al., 1991) 1B11-1B13   (determined by in situ hybridisation)   (Chang et al., 1986)
Experimentally Determined Recombination Data
Location	1-0+
Left of (cM)	brc (Maddern, 1972)
Right of (cM)
Notes	Rare crossovers occur between y and su(s).
Gene Model & Products
Please see the GBrowse view of Dmel\su(s) for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.50 Annotated transcripts do not represent all supported alternative splices within 5' UTR. Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) su(s)-RA FBtr0070120  NM_057406   4901   1325 su(s)-RB FBtr0340081     4889   1321 su(s)-RC FBtr0340082     4657   1325
Additional Transcript Data & Comments
Reported size (kB)	5.0 (northern blot) (Voelker et al., 1989, Voelker et al., 1991)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein su(s)-PA   FBpp0070115   143.8   1325   5.22     NP_476754   AAF45534 su(s)-PB   FBpp0309080   143.4   1321   5.26       su(s)-PC   FBpp0309081   143.8   1325   5.22
Additional Polypeptide Data & Comments
Reported size (kDa)	1322 (aa); 150 (kD observed) (Voelker et al., 1991)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, CCCH-type (IPR000571)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA247027   AA263667   AA439704   AA816943   AE014298 AAF45534   AI296355   AI514981   AI543841   AY071563 AAL49185   BI216860   BI228966   BI354042   BI354984   BI354987   BI375271   BI640734   CO178829   CO307248   CO315522   CO325481   EC089280   EC218645   EV597523   GH753631   GH754222   GH754505   GH755889   GH757840   GH771988   GH773927   GH774526   GH778527   GH781285   GH785521   GH786330   GH792531   GH794979   GH796278   GH806000   GH806019   GH806569   GH807215   GH809684   GH812814   GH821981   GH826450   GH832218   GH839409   GH840581   GH841098   GH853872   GH855640   GH855750   GH863643   GH881458   GH882103   GH891193   GH893497   GH895211   GH897999   GH900254   GH903927   GH905210   GH909478   GH910652   GH910689   GH911679   GH916562   GH917919   GH918782   GH920887   GH921263   GH928324   M57889 AAA28920   X59364 CAA42010   Z32182
UniProtKB/Swiss-Prot	P22293
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References regulatory region FBsf0000161273 X:529,619..529,626 comment= DNA replication-related element (DRE)(TATCGATA) acts as a promoter activating element for the mus209 and DNApol-α180 genes. evidence=predicted (Matsukage et al., 1995)
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference adult stage     (Voelker et al., 1989) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage     (Voelker et al., 1989) embryonic stage -- adult stage     (Voelker et al., 1991)
Additional Descriptive Data
	su(s) transcripts are much more abundant in embryos than adults. (Voelker et al., 1989) su(s) transcript is detected at nearly constant levels in all developmental stages. (Voelker et al., 1991)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage     (Murray et al., 1997) third instar larval stage   salivary gland   • nucleus (Murray et al., 1997) western blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage     (Voelker et al., 1991)
Additional Descriptive Data
	su(s) protein is detected in a reticulated pattern in embryonic and salivary gland nuclei. In the salivary gland the staining localizes mainly to the nucleoplasm. Fewer than 20 sites on salivary gland chromosomes stain strongly with anti-su(s) antibody, and a larger number of sites stain weakly. Most chromosome puffs do not stain strongly. Many (but not all) sites that stain with anti-su(s) antibody also stain with anti-snRNP-U1-70K antibody. (Murray et al., 1997) A 150 kD su(s) protein is observed in nuclear extracts of 0-24 hr embryos; trace amounts are detected in the cytoplasmic fraction. (Voelker et al., 1991)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
nucleoplasm inferred from direct assay (Murray et al., 1997) colocalizes_with transcriptionally active chromatin inferred from direct assay (Kuan et al., 2009)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, adult crop, larval hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    212.675 Larval Midgut    89.8 Larval Hindgut    118.2 Larval Malpighian Tubules    121.6 Larval Fat Body    100 Larval Salivary Gland    157.4 Larval Trachea    173.75 Larval Carcass    131.975 Adult Head    93.4 Adult Eye    106.075 Adult Brain    153.2 Adult Thoracic-Abdominal Ganglion    115.8 Adult Crop    118.2 Adult Midgut    88.5 Adult Hindgut    96.7 Adult Malpighian Tubules    122 Adult Fat Body    115 Adult Salivary Gland    121.6 Adult Heart    105.4 Adult VirginFemale Spermatheca    113.6 Adult InseminatedFemale Spermatheca    111.2 Adult Ovary    229.2 Adult Testis    31.9 Adult Male Accessory Gland    283.9 Adult Carcass    93.5 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    212.675 Larval Midgut    89.8 Larval Hindgut    118.2 Larval Malpighian Tubules    121.6 Larval Fat Body    100 Larval Salivary Gland    157.4 Larval Trachea    173.75 Larval Carcass    131.975 Adult Head    93.4 Adult Eye    106.075 Adult Brain    153.2 Adult Thoracic-Abdominal Ganglion    115.8 Adult Crop    118.2 Adult Midgut    88.5 Adult Hindgut    96.7 Adult Malpighian Tubules    122 Adult Fat Body    115 Adult Salivary Gland    121.6 Adult Heart    105.4 Adult VirginFemale Spermatheca    113.6 Adult InseminatedFemale Spermatheca    111.2 Adult Ovary    229.2 Adult Testis    31.9 Adult Male Accessory Gland    283.9 Adult Carcass    93.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    212.675 Larval Midgut    89.8 Larval Hindgut    118.2 Larval Malpighian Tubules    121.6 Larval Fat Body    100 Larval Salivary Gland    157.4 Larval Trachea    173.75 Larval Carcass    131.975 Adult Head    93.4 Adult Eye    106.075 Adult Brain    153.2 Adult Thoracic-Abdominal Ganglion    115.8 Adult Crop    118.2 Adult Midgut    88.5 Adult Hindgut    96.7 Adult Malpighian Tubules    122 Adult Fat Body    115 Adult Salivary Gland    121.6 Adult Heart    105.4 Adult VirginFemale Spermatheca    113.6 Adult InseminatedFemale Spermatheca    111.2 Adult Ovary    229.2 Adult Testis    31.9 Adult Male Accessory Gland    283.9 Adult Carcass    93.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    212.675 Larval Midgut    89.8 Larval Hindgut    118.2 Larval Malpighian Tubules    121.6 Larval Fat Body    100 Larval Salivary Gland    157.4 Larval Trachea    173.75 Larval Carcass    131.975 Adult Head    93.4 Adult Eye    106.075 Adult Brain    153.2 Adult Thoracic-Abdominal Ganglion    115.8 Adult Crop    118.2 Adult Midgut    88.5 Adult Hindgut    96.7 Adult Malpighian Tubules    122 Adult Fat Body    115 Adult Salivary Gland    121.6 Adult Heart    105.4 Adult VirginFemale Spermatheca    113.6 Adult InseminatedFemale Spermatheca    111.2 Adult Ovary    229.2 Adult Testis    31.9 Adult Male Accessory Gland    283.9 Adult Carcass    93.5 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    212.675 Larval Midgut    89.8 Larval Hindgut    118.2 Larval Malpighian Tubules    121.6 Larval Fat Body    100 Larval Salivary Gland    157.4 Larval Trachea    173.75 Larval Carcass    131.975 Adult Head    93.4 Adult Eye    106.075 Adult Brain    153.2 Adult Thoracic-Abdominal Ganglion    115.8 Adult Crop    118.2 Adult Midgut    88.5 Adult Hindgut    96.7 Adult Malpighian Tubules    122 Adult Fat Body    115 Adult Salivary Gland    121.6 Adult Heart    105.4 Adult VirginFemale Spermatheca    113.6 Adult InseminatedFemale Spermatheca    111.2 Adult Ovary    229.2 Adult Testis    31.9 Adult Male Accessory Gland    283.9 Adult Carcass    93.5 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    212.675 Larval Midgut    89.8 Larval Hindgut    118.2 Larval Malpighian Tubules    121.6 Larval Fat Body    100 Larval Salivary Gland    157.4 Larval Trachea    173.75 Larval Carcass    131.975 Adult Head    93.4 Adult Eye    106.075 Adult Brain    153.2 Adult Thoracic-Abdominal Ganglion    115.8 Adult Crop    118.2 Adult Midgut    88.5 Adult Hindgut    96.7 Adult Malpighian Tubules    122 Adult Fat Body    115 Adult Salivary Gland    121.6 Adult Heart    105.4 Adult VirginFemale Spermatheca    113.6 Adult InseminatedFemale Spermatheca    111.2 Adult Ovary    229.2 Adult Testis    31.9 Adult Male Accessory Gland    283.9 Adult Carcass    93.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    212.675 Larval Midgut    89.8 Larval Hindgut    118.2 Larval Malpighian Tubules    121.6 Larval Fat Body    100 Larval Salivary Gland    157.4 Larval Trachea    173.75 Larval Carcass    131.975 Adult Head    93.4 Adult Eye    106.075 Adult Brain    153.2 Adult Thoracic-Abdominal Ganglion    115.8 Adult Crop    118.2 Adult Midgut    88.5 Adult Hindgut    96.7 Adult Malpighian Tubules    122 Adult Fat Body    115 Adult Salivary Gland    121.6 Adult Heart    105.4 Adult VirginFemale Spermatheca    113.6 Adult InseminatedFemale Spermatheca    111.2 Adult Ovary    229.2 Adult Testis    31.9 Adult Male Accessory Gland    283.9 Adult Carcass    93.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    212.675 Larval Midgut    89.8 Larval Hindgut    118.2 Larval Malpighian Tubules    121.6 Larval Fat Body    100 Larval Salivary Gland    157.4 Larval Trachea    173.75 Larval Carcass    131.975 Adult Head    93.4 Adult Eye    106.075 Adult Brain    153.2 Adult Thoracic-Abdominal Ganglion    115.8 Adult Crop    118.2 Adult Midgut    88.5 Adult Hindgut    96.7 Adult Malpighian Tubules    122 Adult Fat Body    115 Adult Salivary Gland    121.6 Adult Heart    105.4 Adult VirginFemale Spermatheca    113.6 Adult InseminatedFemale Spermatheca    111.2 Adult Ovary    229.2 Adult Testis    31.9 Adult Male Accessory Gland    283.9 Adult Carcass    93.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    93.4   NA  Eye    106.075   NA  Brain    153.2   212.675  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    115.8   NA  Crop    118.2   89.8  Midgut    88.5   118.2  Hindgut    96.7   121.6  Malpighian Tubules    122   100  Fat Body    115   157.4  Salivary Gland    121.6   NA  Heart    105.4   173.75  Trachea    NA   NA  VirginFemale Spermatheca    113.6   NA  InseminatedFemale Spermatheca    111.2   NA  Ovary    229.2   NA  Testis    31.9   NA  Male Accessory Gland    283.9   131.975  Carcass    93.5 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    25 central nervous system, pupae P8    14 head, virgin 1-day female    10 head, virgin 4-day female    11 head, virgin 20-day female    11 head, mated 1-day female    10 head, mated 4-day female    11 head, mated 20-day female    10 head, mated 1-day male    14 head, mated 4-day male    16 head, mated 20-day male    16 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    17 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    9 digestive system, 4-day adult    10 digestive system, 20-day adult    10 fat body, larvae L3 wandering    9 fat body, white prepupae    13 fat body, pupae P8    12 carcass, larvae L3 wandering    18 carcass, 1-day adult    10 carcass, 4-day adult    9 carcass, 20-day adult    9 ovary, virgin 4-day female    34 ovary, mated 4-day female    32 testis, mated 4-day male    8 accessory gland, mated 4-day male    11 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    25 central nervous system, pupae P8    14 head, virgin 1-day female    10 head, virgin 4-day female    11 head, virgin 20-day female    11 head, mated 1-day female    10 head, mated 4-day female    11 head, mated 20-day female    10 head, mated 1-day male    14 head, mated 4-day male    16 head, mated 20-day male    16 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    17 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    9 digestive system, 4-day adult    10 digestive system, 20-day adult    10 fat body, larvae L3 wandering    9 fat body, white prepupae    13 fat body, pupae P8    12 carcass, larvae L3 wandering    18 carcass, 1-day adult    10 carcass, 4-day adult    9 carcass, 20-day adult    9 ovary, virgin 4-day female  (34) ovary, mated 4-day female  (32) testis, mated 4-day male    8 accessory gland, mated 4-day male    11 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    25 central nervous system, pupae P8    14 head, virgin 1-day female    10 head, virgin 4-day female    11 head, virgin 20-day female    11 head, mated 1-day female    10 head, mated 4-day female    11 head, mated 20-day female    10 head, mated 1-day male    14 head, mated 4-day male    16 head, mated 20-day male    16 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    17 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    9 digestive system, 4-day adult    10 digestive system, 20-day adult    10 fat body, larvae L3 wandering    9 fat body, white prepupae    13 fat body, pupae P8    12 carcass, larvae L3 wandering    18 carcass, 1-day adult    10 carcass, 4-day adult    9 carcass, 20-day adult    9 ovary, virgin 4-day female    34 ovary, mated 4-day female    32 testis, mated 4-day male    8 accessory gland, mated 4-day male    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    25 central nervous system, pupae P8    14 head, virgin 1-day female    10 head, virgin 4-day female    11 head, virgin 20-day female    11 head, mated 1-day female    10 head, mated 4-day female    11 head, mated 20-day female    10 head, mated 1-day male    14 head, mated 4-day male    16 head, mated 20-day male    16 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    17 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    9 digestive system, 4-day adult    10 digestive system, 20-day adult    10 fat body, larvae L3 wandering    9 fat body, white prepupae    13 fat body, pupae P8    12 carcass, larvae L3 wandering    18 carcass, 1-day adult    10 carcass, 4-day adult    9 carcass, 20-day adult    9 ovary, virgin 4-day female    34 ovary, mated 4-day female    32 testis, mated 4-day male    8 accessory gland, mated 4-day male    11 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    25 central nervous system, pupae P8    14 head, virgin 1-day female    10 head, virgin 4-day female    11 head, virgin 20-day female    11 head, mated 1-day female    10 head, mated 4-day female    11 head, mated 20-day female    10 head, mated 1-day male    14 head, mated 4-day male    16 head, mated 20-day male    16 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    17 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    9 digestive system, 4-day adult    10 digestive system, 20-day adult    10 fat body, larvae L3 wandering    9 fat body, white prepupae    13 fat body, pupae P8    12 carcass, larvae L3 wandering    18 carcass, 1-day adult    10 carcass, 4-day adult    9 carcass, 20-day adult    9 ovary, virgin 4-day female    34 ovary, mated 4-day female    32 testis, mated 4-day male    8 accessory gland, mated 4-day male    11 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    25 central nervous system, pupae P8    14 head, virgin 1-day female    10 head, virgin 4-day female    11 head, virgin 20-day female    11 head, mated 1-day female    10 head, mated 4-day female    11 head, mated 20-day female    10 head, mated 1-day male    14 head, mated 4-day male    16 head, mated 20-day male    16 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    17 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    9 digestive system, 4-day adult    10 digestive system, 20-day adult    10 fat body, larvae L3 wandering    9 fat body, white prepupae    13 fat body, pupae P8    12 carcass, larvae L3 wandering    18 carcass, 1-day adult    10 carcass, 4-day adult    9 carcass, 20-day adult    9 ovary, virgin 4-day female  (34) ovary, mated 4-day female  32 testis, mated 4-day male    8 accessory gland, mated 4-day male    11 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    25 central nervous system, pupae P8    14 head, virgin 1-day female    10 head, virgin 4-day female    11 head, virgin 20-day female    11 head, mated 1-day female    10 head, mated 4-day female    11 head, mated 20-day female    10 head, mated 1-day male    14 head, mated 4-day male    16 head, mated 20-day male    16 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    17 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    9 digestive system, 4-day adult    10 digestive system, 20-day adult    10 fat body, larvae L3 wandering    9 fat body, white prepupae    13 fat body, pupae P8    12 carcass, larvae L3 wandering    18 carcass, 1-day adult    10 carcass, 4-day adult    9 carcass, 20-day adult    9 ovary, virgin 4-day female    34 ovary, mated 4-day female    32 testis, mated 4-day male    8 accessory gland, mated 4-day male    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    25 central nervous system, pupae P8    14 head, virgin 1-day female    10 head, virgin 4-day female    11 head, virgin 20-day female    11 head, mated 1-day female    10 head, mated 4-day female    11 head, mated 20-day female    10 head, mated 1-day male    14 head, mated 4-day male    16 head, mated 20-day male    16 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    17 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    9 digestive system, 4-day adult    10 digestive system, 20-day adult    10 fat body, larvae L3 wandering    9 fat body, white prepupae    13 fat body, pupae P8    12 carcass, larvae L3 wandering    18 carcass, 1-day adult    10 carcass, 4-day adult    9 carcass, 20-day adult    9 ovary, virgin 4-day female    34 ovary, mated 4-day female    32 testis, mated 4-day male    8 accessory gland, mated 4-day male    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, during early pupal stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    30 embryo 02-04hr    43 embryo 04-06hr    28 embryo 06-08hr    28 embryo 08-10hr    26 embryo 10-12hr    22 embryo 12-14hr    19 embryo 14-16hr    24 embryo 16-18hr    20 embryo 18-20hr    17 embryo 20-22hr    26 embryo 22-24hr    22 larva L1    12 larva L2    9 larva L3 12hr old    8 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    12 white prepupae new    14 white prepupae 12hr    16 white prepupae 24hr    19 pupae 2d postWPP    17 pupae 3d postWPP    13 pupae 4d postWPP    11 adult male 01day    10 adult male 05day    11 adult male 30day    11 adult female 01day    16 adult female 05day    20 adult female 30day    21 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (30) embryo 02-04hr  (43) embryo 04-06hr  (28) embryo 06-08hr  (28) embryo 08-10hr  26 embryo 10-12hr    22 embryo 12-14hr    19 embryo 14-16hr    24 embryo 16-18hr    20 embryo 18-20hr    17 embryo 20-22hr  26 embryo 22-24hr    22 larva L1    12 larva L2    9 larva L3 12hr old    8 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    12 white prepupae new    14 white prepupae 12hr    16 white prepupae 24hr    19 pupae 2d postWPP    17 pupae 3d postWPP    13 pupae 4d postWPP    11 adult male 01day    10 adult male 05day    11 adult male 30day    11 adult female 01day    16 adult female 05day    20 adult female 30day    21 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    30 embryo 02-04hr    43 embryo 04-06hr    28 embryo 06-08hr    28 embryo 08-10hr    26 embryo 10-12hr    22 embryo 12-14hr    19 embryo 14-16hr    24 embryo 16-18hr    20 embryo 18-20hr    17 embryo 20-22hr    26 embryo 22-24hr    22 larva L1    12 larva L2    9 larva L3 12hr old    8 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    12 white prepupae new    14 white prepupae 12hr    16 white prepupae 24hr    19 pupae 2d postWPP    17 pupae 3d postWPP    13 pupae 4d postWPP    11 adult male 01day    10 adult male 05day    11 adult male 30day    11 adult female 01day    16 adult female 05day    20 adult female 30day    21 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    30 embryo 02-04hr    43 embryo 04-06hr    28 embryo 06-08hr    28 embryo 08-10hr    26 embryo 10-12hr    22 embryo 12-14hr    19 embryo 14-16hr    24 embryo 16-18hr    20 embryo 18-20hr    17 embryo 20-22hr    26 embryo 22-24hr    22 larva L1    12 larva L2    9 larva L3 12hr old    8 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    12 white prepupae new    14 white prepupae 12hr    16 white prepupae 24hr    19 pupae 2d postWPP    17 pupae 3d postWPP    13 pupae 4d postWPP    11 adult male 01day    10 adult male 05day    11 adult male 30day    11 adult female 01day    16 adult female 05day    20 adult female 30day    21 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    30 embryo 02-04hr    43 embryo 04-06hr    28 embryo 06-08hr    28 embryo 08-10hr    26 embryo 10-12hr    22 embryo 12-14hr    19 embryo 14-16hr    24 embryo 16-18hr    20 embryo 18-20hr    17 embryo 20-22hr    26 embryo 22-24hr    22 larva L1    12 larva L2    9 larva L3 12hr old    8 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    12 white prepupae new    14 white prepupae 12hr    16 white prepupae 24hr    19 pupae 2d postWPP    17 pupae 3d postWPP    13 pupae 4d postWPP    11 adult male 01day    10 adult male 05day    11 adult male 30day    11 adult female 01day    16 adult female 05day    20 adult female 30day    21 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  30 embryo 02-04hr  (43) embryo 04-06hr  28 embryo 06-08hr  28 embryo 08-10hr  26 embryo 10-12hr    22 embryo 12-14hr    19 embryo 14-16hr    24 embryo 16-18hr    20 embryo 18-20hr    17 embryo 20-22hr  26 embryo 22-24hr    22 larva L1    12 larva L2    9 larva L3 12hr old    8 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    12 white prepupae new    14 white prepupae 12hr    16 white prepupae 24hr    19 pupae 2d postWPP    17 pupae 3d postWPP    13 pupae 4d postWPP    11 adult male 01day    10 adult male 05day    11 adult male 30day    11 adult female 01day    16 adult female 05day    20 adult female 30day    21 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    30 embryo 02-04hr    43 embryo 04-06hr    28 embryo 06-08hr    28 embryo 08-10hr    26 embryo 10-12hr    22 embryo 12-14hr    19 embryo 14-16hr    24 embryo 16-18hr    20 embryo 18-20hr    17 embryo 20-22hr    26 embryo 22-24hr    22 larva L1    12 larva L2    9 larva L3 12hr old    8 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    12 white prepupae new    14 white prepupae 12hr    16 white prepupae 24hr    19 pupae 2d postWPP    17 pupae 3d postWPP    13 pupae 4d postWPP    11 adult male 01day    10 adult male 05day    11 adult male 30day    11 adult female 01day    16 adult female 05day    20 adult female 30day    21 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    30 embryo 02-04hr    43 embryo 04-06hr    28 embryo 06-08hr    28 embryo 08-10hr    26 embryo 10-12hr    22 embryo 12-14hr    19 embryo 14-16hr    24 embryo 16-18hr    20 embryo 18-20hr    17 embryo 20-22hr    26 embryo 22-24hr    22 larva L1    12 larva L2    9 larva L3 12hr old    8 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    12 white prepupae new    14 white prepupae 12hr    16 white prepupae 24hr    19 pupae 2d postWPP    17 pupae 3d postWPP    13 pupae 4d postWPP    11 adult male 01day    10 adult male 05day    11 adult male 30day    11 adult female 01day    16 adult female 05day    20 adult female 30day    21 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    27 Schneider line 2 Sg4    23 embryonic 1182-4H    18 embryonic GM2    11 embryonic Kc167    16 embryonic S1    17 embryonic S3    13 leg disc CME L1    20 wing disc CME-W2    11 wing disc ML-DmD8    13 wing disc ML-DmD9    23 wing disc ML-DmD16-c3    18 wing disc ML-DmD21    15 wing disc ML-DmD32    16 haltere disc ML-DmD17-c3    16 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    10 CNS ML-DmBG2-c2    9 tumorous blood cells mbn2    14 ovary fGS/OSS    33 ovary OSC    32 ovary OSS    16 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (27) Schneider line 2 Sg4    23 embryonic 1182-4H    18 embryonic GM2    11 embryonic Kc167    16 embryonic S1    17 embryonic S3    13 leg disc CME L1    20 wing disc CME-W2    11 wing disc ML-DmD8    13 wing disc ML-DmD9    23 wing disc ML-DmD16-c3    18 wing disc ML-DmD21    15 wing disc ML-DmD32    16 haltere disc ML-DmD17-c3    16 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    10 CNS ML-DmBG2-c2    9 tumorous blood cells mbn2    14 ovary fGS/OSS  (33) ovary OSC  (32) ovary OSS    16 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    27 Schneider line 2 Sg4    23 embryonic 1182-4H    18 embryonic GM2    11 embryonic Kc167    16 embryonic S1    17 embryonic S3    13 leg disc CME L1    20 wing disc CME-W2    11 wing disc ML-DmD8    13 wing disc ML-DmD9    23 wing disc ML-DmD16-c3    18 wing disc ML-DmD21    15 wing disc ML-DmD32    16 haltere disc ML-DmD17-c3    16 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    10 CNS ML-DmBG2-c2    9 tumorous blood cells mbn2    14 ovary fGS/OSS    33 ovary OSC    32 ovary OSS    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    27 Schneider line 2 Sg4    23 embryonic 1182-4H    18 embryonic GM2    11 embryonic Kc167    16 embryonic S1    17 embryonic S3    13 leg disc CME L1    20 wing disc CME-W2    11 wing disc ML-DmD8    13 wing disc ML-DmD9    23 wing disc ML-DmD16-c3    18 wing disc ML-DmD21    15 wing disc ML-DmD32    16 haltere disc ML-DmD17-c3    16 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    10 CNS ML-DmBG2-c2    9 tumorous blood cells mbn2    14 ovary fGS/OSS    33 ovary OSC    32 ovary OSS    16 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    27 Schneider line 2 Sg4    23 embryonic 1182-4H    18 embryonic GM2    11 embryonic Kc167    16 embryonic S1    17 embryonic S3    13 leg disc CME L1    20 wing disc CME-W2    11 wing disc ML-DmD8    13 wing disc ML-DmD9    23 wing disc ML-DmD16-c3    18 wing disc ML-DmD21    15 wing disc ML-DmD32    16 haltere disc ML-DmD17-c3    16 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    10 CNS ML-DmBG2-c2    9 tumorous blood cells mbn2    14 ovary fGS/OSS    33 ovary OSC    32 ovary OSS    16 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  27 Schneider line 2 Sg4    23 embryonic 1182-4H    18 embryonic GM2    11 embryonic Kc167    16 embryonic S1    17 embryonic S3    13 leg disc CME L1    20 wing disc CME-W2    11 wing disc ML-DmD8    13 wing disc ML-DmD9    23 wing disc ML-DmD16-c3    18 wing disc ML-DmD21    15 wing disc ML-DmD32    16 haltere disc ML-DmD17-c3    16 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    10 CNS ML-DmBG2-c2    9 tumorous blood cells mbn2    14 ovary fGS/OSS  (33) ovary OSC  32 ovary OSS    16 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    27 Schneider line 2 Sg4    23 embryonic 1182-4H    18 embryonic GM2    11 embryonic Kc167    16 embryonic S1    17 embryonic S3    13 leg disc CME L1    20 wing disc CME-W2    11 wing disc ML-DmD8    13 wing disc ML-DmD9    23 wing disc ML-DmD16-c3    18 wing disc ML-DmD21    15 wing disc ML-DmD32    16 haltere disc ML-DmD17-c3    16 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    10 CNS ML-DmBG2-c2    9 tumorous blood cells mbn2    14 ovary fGS/OSS    33 ovary OSC    32 ovary OSS    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    27 Schneider line 2 Sg4    23 embryonic 1182-4H    18 embryonic GM2    11 embryonic Kc167    16 embryonic S1    17 embryonic S3    13 leg disc CME L1    20 wing disc CME-W2    11 wing disc ML-DmD8    13 wing disc ML-DmD9    23 wing disc ML-DmD16-c3    18 wing disc ML-DmD21    15 wing disc ML-DmD32    16 haltere disc ML-DmD17-c3    16 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    10 CNS ML-DmBG2-c2    9 tumorous blood cells mbn2    14 ovary fGS/OSS    33 ovary OSC    32 ovary OSS    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    14 cold shock, 4-day adult    11 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    22 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    24 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    18 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    18 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    14 cold shock, 4-day adult    11 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    22 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    24 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    18 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    18 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    14 cold shock, 4-day adult    11 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    22 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    24 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    18 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    18 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    14 cold shock, 4-day adult    11 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    22 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    24 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    18 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    18 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    14 cold shock, 4-day adult    11 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    22 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    24 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    18 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    18 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    14 cold shock, 4-day adult    11 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    22 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    24 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    18 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    18 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    14 cold shock, 4-day adult    11 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    22 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    24 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    18 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    18 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    14 cold shock, 4-day adult    11 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    22 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    24 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    18 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    18 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_01 mE1_20_mRNA_expression_cluster_09
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003575 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6222-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4e22c su(s)Scer\UAS.cTa lethal | recessive su(s)38 partially lethal - majority die, with Scer\GAL4T80 su(s)Scer\UAS.cTa partially lethal - majority die | pupal stage, with Scer\GAL4pnr-MD237 su(s)GD4413 partially lethal - majority live su(s)11 su(s)17 partially lethal - majority live, with Scer\GAL469B su(s)Scer\UAS.cTa partially lethal - majority live, with Scer\GAL4hs.2sev su(s)Scer\UAS.cTa su(s)ΔARM1,2.Scer\UAS su(s)ΔARM1.Scer\UAS su(s)ΔARM2.Scer\UAS viable, with Scer\GAL430A su(s)Scer\UAS.cTa viable, with Scer\GAL4hs.PB su(s)Scer\UAS.cTa viable | good su(s)9 su(s)13 su(s)21 su(s)22 su(s)23 su(s)25 su(s)26 su(s)27 viable | reduced su(s)10 su(s)12 su(s)14 su(s)15 su(s)16 su(s)24 Sterility Allele male fertile | cold sensitive su(s)35 su(s)49 su(s)61 male sterile | partially | recessive su(s)3 su(s)35 male sterile | recessive su(s)38 male sterile | recessive | cold sensitive su(s)37 su(s)52 su(s)54 su(s)56 su(s)57 su(s)59 su(s)60 su(s)62 su(s)63 su(s)65 su(s)67 su(s)69 su(s)70 Other Phenotypes Allele visible, with Scer\GAL4pnr-MD237 su(s)GD4413 wild-type su(s)#4 su(s)+t12 Phenotype manifest in Allele mesothoracic tergum, with Scer\GAL4pnr-MD237 su(s)GD4413 trichogen cell, with Scer\GAL4pnr-MD237 su(s)GD4413
Classical Alleles ( 143 )
For All Classical Alleles Show
Allele of su(s) Class Mutagen Stocks Known lesion su(s)2 spontaneous 3 Yes su(s)1 spontaneous 1 -- su(s)28 DNA 1 Yes su(s)2rv spontaneous 1 Yes su(s)37 ethyl methanesulfonate 1 Yes su(s)40 spontaneous 1 Yes su(s)6 spontaneous 1 Yes su(s)KG05922 1 -- su(s)100 gamma ray 0 -- su(s)101 gamma ray 0 -- su(s)102 gamma ray 0 -- su(s)103 gamma ray 0 -- su(s)104 gamma ray 0 -- su(s)105 gamma ray 0 -- su(s)106 gamma ray 0 -- su(s)107 gamma ray 0 -- su(s)108 gamma ray 0 -- su(s)109 gamma ray 0 -- su(s)10 ethyl methanesulfonate 0 -- su(s)110 gamma ray 0 -- su(s)111 gamma ray 0 -- su(s)112 gamma ray 0 -- su(s)113 gamma ray 0 -- su(s)114 gamma ray 0 -- su(s)115 gamma ray 0 -- su(s)116 gamma ray 0 -- su(s)117 gamma ray 0 -- su(s)118 gamma ray 0 -- su(s)119 gamma ray 0 -- su(s)11 N-methyl-N'-nitro-N-nitrosoguanidine 0 -- su(s)120 gamma ray 0 -- su(s)121 gamma ray 0 -- su(s)122 gamma ray 0 -- su(s)123 gamma ray 0 -- su(s)124 gamma ray 0 -- su(s)125 gamma ray 0 -- su(s)126 gamma ray 0 -- su(s)127 gamma ray 0 -- su(s)128 gamma ray 0 -- su(s)129 gamma ray 0 -- su(s)12 N-methyl-N'-nitro-N-nitrosoguanidine 0 -- su(s)130 gamma ray 0 -- su(s)131 gamma ray 0 -- su(s)132 gamma ray 0 -- su(s)133 gamma ray 0 -- su(s)13 ethyl methanesulfonate 0 -- su(s)14 ethyl methanesulfonate 0 -- su(s)15 ethyl methanesulfonate 0 -- su(s)16 ethyl methanesulfonate 0 -- su(s)17 ethyl methanesulfonate 0 -- su(s)18-19 PM hybrid dysgenesis 0 -- su(s)18-2 PM hybrid dysgenesis 0 -- su(s)18 ethyl methanesulfonate 0 -- su(s)19 ethyl methanesulfonate 0 -- su(s)20 ethyl methanesulfonate 0 -- su(s)21 X ray 0 -- su(s)22 X ray 0 -- su(s)23 X ray 0 -- su(s)24 X ray 0 -- su(s)25 X ray 0 -- su(s)26 X ray 0 -- su(s)27 X ray 0 -- su(s)29 DNA 0 Yes su(s)30 ethyl methanesulfonate 0 Yes su(s)31 ethyl methanesulfonate 0 Yes su(s)32 ethyl methanesulfonate 0 Yes su(s)33 ethyl methanesulfonate 0 Yes su(s)34 ethyl methanesulfonate 0 Yes su(s)35 X ray ethyl methanesulfonate 0 Yes su(s)36 X ray 0 Yes su(s)38 ethyl methanesulfonate 0 Yes su(s)39 PM hybrid dysgenesis P-element activity 0 Yes su(s)3 X ray 0 Yes su(s)41 spontaneous 0 Yes su(s)42 PM hybrid dysgenesis MR 0 Yes su(s)43 PM hybrid dysgenesis MR 0 Yes su(s)44 PM hybrid dysgenesis MR 0 Yes su(s)45 PM hybrid dysgenesis MR 0 Yes su(s)46 PM hybrid dysgenesis 0 -- su(s)47 spontaneous 0 Yes su(s)48 ethyl nitrosourea 0 Yes su(s)49 ethyl nitrosourea 0 Yes su(s)4 spontaneous 0 Yes su(s)5-HA-2184 0 -- su(s)50 ethyl nitrosourea 0 Yes su(s)51 spontaneous 0 Yes su(s)52 ethyl nitrosourea 0 Yes su(s)53 ethyl nitrosourea 0 Yes su(s)54 ethyl nitrosourea 0 Yes su(s)55 ethyl nitrosourea 0 Yes su(s)56 ethyl nitrosourea 0 Yes su(s)57 ethyl nitrosourea 0 Yes su(s)58 ethyl nitrosourea 0 -- su(s)59 ethyl nitrosourea 0 Yes su(s)5 X ray 0 -- su(s)60 ethyl nitrosourea 0 Yes su(s)61 ethyl nitrosourea 0 Yes su(s)62 ethyl nitrosourea 0 Yes su(s)63 ethyl nitrosourea 0 Yes su(s)64 ethyl nitrosourea 0 Yes su(s)65 ethyl nitrosourea 0 Yes su(s)66 ethyl nitrosourea 0 -- su(s)67 ethyl nitrosourea 0 Yes su(s)68 ethyl nitrosourea 0 -- su(s)69 ethyl methanesulfonate 0 Yes su(s)70 ethyl methanesulfonate 0 Yes su(s)71 spontaneous 0 Yes su(s)72 ethyl methanesulfonate 0 -- su(s)73 gamma ray 0 -- su(s)74 gamma ray 0 -- su(s)75 gamma ray 0 -- su(s)76 gamma ray 0 -- su(s)77 gamma ray 0 -- su(s)78 gamma ray 0 -- su(s)79 gamma ray 0 -- su(s)7 spontaneous 0 Yes su(s)80 gamma ray 0 -- su(s)81 gamma ray 0 -- su(s)82 gamma ray 0 -- su(s)83 gamma ray 0 -- su(s)84 gamma ray 0 -- su(s)85 gamma ray 0 -- su(s)86 gamma ray 0 -- su(s)87 gamma ray 0 -- su(s)88 gamma ray 0 -- su(s)89 gamma ray 0 -- su(s)8 spontaneous 0 -- su(s)90 gamma ray 0 -- su(s)91 gamma ray 0 -- su(s)92 gamma ray 0 -- su(s)93 gamma ray 0 -- su(s)94 PM hybrid dysgenesis 0 Yes su(s)95 PM hybrid dysgenesis 0 Yes su(s)96 gamma ray 0 -- su(s)97 gamma ray 0 -- su(s)98 gamma ray 0 -- su(s)99 gamma ray 0 -- su(s)9 hypomorphic allele - genetic evidence spontaneous 0 Yes su(s)GG01023 0 -- su(s)R39 loss of function allele 0 -- su(s)RT423 irradiation 0 -- su(s)RT464 irradiation 0 -- su(s)sn-w:R spontaneous 0 Yes
Alleles Carried on Transgenic Constructs ( 10 )
For All Alleles Carried on Transgenic Constructs Show
Allele of su(s) Class Mutagen Stocks Known lesion su(s)GD4413 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes su(s)HMS00942 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes su(s)#4 in vitro construct - genomic fragment 0 Yes su(s)+t12 in vitro construct - genomic fragment 0 Yes su(s)NIG.6222R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes su(s)Scer\UAS.cTa in vitro construct - regulatory fusion 0 Yes su(s)tCa in vitro construct 0 Yes su(s)ΔARM1,2.Scer\UAS in vitro construct - deletion 0 Yes su(s)ΔARM1.Scer\UAS in vitro construct - deletion 0 Yes su(s)ΔARM2.Scer\UAS in vitro construct - deletion 0 Yes
Aneuploid Aberrations
Duplicated in	Dp(1;f)3 (Rayle and Hoar, 1969) Dp(1;f)18 (Rayle and Hoar, 1969) Dp(1;f)101 (Rayle and Hoar, 1969) Dp(1;f)1337 (Rayle and Hoar, 1969) Dp(1;Y)1E (Masterson, 1968) Dp(1;Y)2E (Masterson, 1968) Dp(1;Y)59k9-1 (Rayle and Hoar, 1969) Dp(1;Y)60e17.4-3 (Rayle and Hoar, 1969) Dp(1;Y)68h20 (Rayle and Hoar, 1969) Ts(1Lt;2Lt)Bld
Not duplicated in	Dp(1;3)wvco (Rayle and Hoar, 1969) Dp(1;Y)2E-C (Rayle and Hoar, 1969)
Not disrupted in	Df(1)svr (Voelker et al., 1989, California Institute of Technology, 1940) Df(1)y74k10.1 (Voelker et al., 1989) Df(1)y74k24.1 (Voelker et al., 1989) Df(1)yT4-8 (Sherald and Voelker, 1985) Df(1)yT4-20 (Sherald and Voelker, 1985) Df(1)yT9-7 (Voelker et al., 1989) Df(1)yT9-21 (Voelker et al., 1989) Df(1)yT9-220 (Voelker et al., 1989) Df(1)yT9-275 (Voelker et al., 1989) Df(1)yT10-102 (Voelker et al., 1989) Df(1)yT10-106 (Voelker et al., 1989) Df(1)yT10-581 (Voelker et al., 1989) Df(1)yT10-665 (Voelker et al., 1989) Df(1)yT10-673 (Voelker et al., 1989) Df(1)yT10-677 (Voelker et al., 1989)
Disrupted in	Df(1)su(s)2 (Voelker et al., 1989) Df(1)su(s)3 (Voelker et al., 1989) Df(1)su(s)83 (Voelker et al., 1989) Df(1)su(s)R194 (Duffy et al., 1996) Df(1)yT13-423 (Voelker et al., 1989) Df(1)yT13-464 (Voelker et al., 1989) Df(1)yT14-546 (Voelker et al., 1989) Df(1)yT14-576 (Voelker et al., 1989) Df(1)yT15-5 (Voelker et al., 1989) Df(1)yT15-6 (Voelker et al., 1989) Df(1)yT15-28 (Voelker et al., 1989) Df(1)yT15-56 (Voelker et al., 1989) Df(1)yT15-105 (Voelker et al., 1989) Df(1)yT15-158b (Voelker et al., 1989) Df(1)yT15-161 (Voelker et al., 1989) Df(1)yT15-171 (Voelker et al., 1989) Df(1)yT15-177 (Voelker et al., 1989) Df(1)yT15-183 (Voelker et al., 1989) Df(1)yT15-189 (Voelker et al., 1989) Df(1)yT15-219 (Voelker et al., 1989) Df(1)yT15-222 (Voelker et al., 1989) Df(1)yT15-270 (Voelker et al., 1989) Df(1)yT15-274 (Voelker et al., 1989) Df(1)yT15-286 (Voelker et al., 1989) Df(1)yT15-300 (Voelker et al., 1989) Df(1)yT15-318 (Voelker et al., 1989) Df(1)yT15-325 (Voelker et al., 1989) Df(1)yT15-327 (Voelker et al., 1989) Df(1)yT15-334 (Voelker et al., 1989) Df(1)yT15-364 (Voelker et al., 1989) Df(1)yT15-365 (Voelker et al., 1989) Df(1)yT15-383 (Voelker et al., 1989) Df(1)yT15-390 (Voelker et al., 1989) Df(1)yT15-392 (Voelker et al., 1989) Df(1)yT15-405 (Voelker et al., 1989) Df(1)yT15-408 (Voelker et al., 1989) Df(1)yT15-410 (Voelker et al., 1989) Df(1)yT15-412 (Voelker et al., 1989) Df(1)yT15-433 (Voelker et al., 1989) Df(1)yT15-449 (Voelker et al., 1989) Df(1)yT15-460 (Voelker et al., 1989) Df(1)yT15-468 (Voelker et al., 1989) Df(1)yT15-502 (Voelker et al., 1989) Df(1)yT15-509 (Voelker et al., 1989) Df(1)yT15-511 (Voelker et al., 1989) Df(1)yT15-517 (Voelker et al., 1989) Df(1)yT15-533 (Voelker et al., 1989) Df(1)yT15-543 (Voelker et al., 1989) Df(1)yT15-548 (Voelker et al., 1989) Df(1)yT15-552 (Voelker et al., 1989) Df(1)yT15-564 (Voelker et al., 1989) Df(1)yT15-568 (Voelker et al., 1989) Df(1)yT15-575 (Voelker et al., 1989) Df(1)yT15-586 (Voelker et al., 1989) Df(1)yT15-597 (Voelker et al., 1989) Df(1)yT15-599 (Voelker et al., 1989) Df(1)yT16-14 (Voelker et al., 1989) Df(1)yT16-411 (Voelker et al., 1989) Df(1)yT16-499 (Voelker et al., 1989) Df(1)yT16-534 (Voelker et al., 1989) Df(1)yT16-554 (Voelker et al., 1989) Df(1)yT17-570 (Voelker et al., 1989) Df(1)yT17-600 (Voelker et al., 1989) Df(1)yT18-319 (Voelker et al., 1989) Df(1)yT19-16 (Voelker et al., 1989) Df(1)yT19-253 (Voelker et al., 1989) Dp(1;3)su(s)E2 (Voelker et al., 1989) Ts(1Rt;2Rt)Bld (California Institute of Technology, 1940)
Partially disrupted in	Df(1)yT8-206 (Voelker et al., 1989) Df(1)yT12-173 (Voelker et al., 1989) Df(1)yT12-187 (Voelker et al., 1989) Df(1)yT12-200 (Voelker et al., 1989) Df(1)yT12-246 (Voelker et al., 1989) Df(1)yT12-667 (Voelker et al., 1989)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4413} NA P{NIG.6222R} NA P{TRiP.HMS00942} NA P{UAS-su(s).T} NA P{UAS-su(s).ΔARM1,2} NA P{UAS-su(s).ΔARM1} NA P{UAS-su(s).ΔARM2} NA characterization construct P{18D#3} NA P{18D#4} NA P{MtnvkLTR5'con} NA P{MtnvkLTR} NA P{MtnvkLTRΔ5'3'ss} NA P{MtnvkLTRΔ5'ss} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions 17.6{}su(s)29 NA Delta88{}su(s)28 NA gypsy{?'}su(s)2rv NA gypsy{}su(s)2 NA gypsy{}su(s)6 NA gypsy{}su(s)7 NA HMS-Beagle{}su(s)40 NA P{}su(s)39 NA P{}su(s)42 NA P{}su(s)43 NA P{}su(s)44 NA P{}su(s)45 NA P{}su(s)94 NA P{}su(s)95 NA P{RS5}su(s)5-HA-2184 NA P{SUPor-P}su(s)KG05922 NA roamer{}su(s)41 NA roamer{}su(s)51 NA rover{}su(s)9 NA S{}su(s)71 NA springer{}su(s)47 NA Stalker{}su(s)4 NA insertion of mobile activating element P{Mae-UAS.6.11}su(s)GG01023 NA
Gene Ontology: Function, Process & Cellular Component ( 7 unique terms )
Terms Based on Experimental Evidence ( 4 terms )
Molecular Function
CV term Evidence References
RNA binding inferred from direct assay (Murray et al., 1997)
Biological Process
CV term Evidence References
nuclear RNA surveillance inferred from mutant phenotype (Kuan et al., 2009)
Cellular Component
CV term Evidence References
nucleoplasm inferred from direct assay (Murray et al., 1997) colocalizes_with transcriptionally active chromatin inferred from direct assay (Kuan et al., 2009)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
mRNA binding non-traceable author statement (Kuan and Searles, 2002) zinc ion binding inferred from electronic annotation with InterPro:IPR000571 (FlyBase Curators et al., 2004-)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
nucleus non-traceable author statement (Swiss-Prot Project Members, 1991.8.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions su(s) allele Gene References su(s)2 pr (Kim et al., 1996) su(s)30 s (Voelker et al., 1989) su(s)31 s (Voelker et al., 1989) su(s)32 s (Voelker et al., 1989) su(s)33 s (Voelker et al., 1989) su(s)39 v (Voelker et al., 1989) su(s)48 v (Voelker et al., 1989) su(s)49 v (Voelker et al., 1989) su(s)50 v (Voelker et al., 1989) unspecified s (Voelker et al., 1989, Kim et al., 1996) sp (Warner et al., 1975) v (Schultz and Bridges, 1932, Green, 1952, Shapard, 1960, Baglioni, 1960, Kaufman, 1962, Marzluf, 1965, Tartof, 1969, Voelker et al., 1989, Fridell et al., 1990, Jacobson et al., 1982) y (Geyer et al., 1991)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 57580 DroID - A comprehensive database of gene and protein interactions. • FBgn0003575 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31012
Orthologs
OrthoDB Orthologs (29) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6XKVTR Dipteran inclusive ortholog search EOG680J58 Insect inclusive ortholog search EOG6R22PX Arthropod inclusive ortholog search EOG6NGF2Q Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG6XKVTR)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\su(s)     Drosophila sechellia   Dsec\GM19080 Y   Drosophila erecta   Dere\su(s) Y   Drosophila yakuba   Dyak\su(s) Y   Drosophila ananassae   Dana\GF20966 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA19452 Y   Drosophila persimilis   Dper\GL26884 Y   Drosophila willistoni   Dwil\GK16443 Y   Drosophila virilis   Dvir\GJ16696     Drosophila mojavensis   Dmoj\GI21572 Y   Drosophila grimshawi   Dgri\GH24171 Y
Orthologs in non-Drosophila Dipterans (EOG680J58)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL010074   Anopheles gambiae Malaria mosquito  Agam\AGAP011127   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ002528
Orthologs in non-Dipteran Insects (EOG6R22PX)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB54658   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG011900   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH12725   Atta cephalotes Leafcutter ant  Acep\ACEP16487   Camponotus floridanus Florida carpenter ant  Cflo\CFLO17754   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL14056   Linepithema humile Argentine ant  Lhum\LH25707   Pogonomyrmex barbatus Red harvester ant  Pbar\PB22517   Solenopsis invicta Red fire ant  Sinv\SINV22264   Acyrthosiphon pisum Pea aphid  Apim\ACYPI004857   Bombyx mori Silkmoth  Bmor\BGIBMGA005470   Pediculus humanus Human body louse  Phum\PHUM156690   Tribolium castaneum Red flour beetle  Tcas\TC006035
Orthologs in non-Insect Arthropods (EOG6NGF2Q)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_303546   Ixodes scapularis Deer tick  Isca\ISCW015961
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (10) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila sechellia Dsec\GM19080 Drosophila erecta Dere\su(s) Drosophila yakuba Dyak\su(s) Drosophila ananassae Dana\GF20966 Drosophila pseudoobscura pseudoobscura Dpse\GA19452 Drosophila persimilis Dper\GL26884 Drosophila willistoni Dwil\GK16443 Drosophila virilis Dvir\su(s) Drosophila mojavensis Dmoj\GI21572 Drosophila grimshawi Dgri\GH24171
Stocks & Reagents
Stocks Listed in FlyBase ( 13 )
Bloomington	14461 y1 P{SUPor-P}su(s)KG05922 121 su(s)2rv wa cv1 t1 33982 y1 sc* v1; P{TRiP.HMS00942}attP2 2232 y2 su(s)6 ras2 v1 f1 su(f)1 1157 y2 sc1 su(s)2 lz1 f1 su(f)8/FM6 4152 y2 su(s)37 lz1/C(1)DX, y1 w1 f1
Kyoto	101190 su(s)1 101830 su(s)28 v1 ; bw1 103226 y1 su(s)40 / Dp(1;Y)y+ 101193 Dp(1;Y)59k9-2, y2 sc+ su(s)2 su(wa)+ sta+ / y59b z1
VDRC	v10853 w1118 P{GD4413}v10853 v10854 w1118 P{GD4413}v10854
	More stocks available...
Genomic Clones ( 1 )
	BACR16G06 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 71 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE63043
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GM26077 GM29128 GM29137 LD06130 LD06838 LD14339 LD21817 LD39941 LD46632 LP10222 RE24142 RE26640 SD23720
Other clones	158870 CK01.72D.F4 Dmel_neb_012012_0902_3128 EK057654 EK196626 EK254201 EK261736 RP003024157 RP003028662 RP003037637 RP003042425 RP003048509 RP003051791 RP003074090 RP003074590 RP003075879 RP003085044 RP003090075 RP003093769 RP003120903 RP003134266 RP003135309 RP003158419 RP003170333 RP003171873 RP003172848 RP003173395 RP003186209 RP003192175 RP003195810 RP003230923 RP003240093 RP003247556 RP003253083 RP003273534 RP003276332 RP003277666 RP003294745 RP003305919 RP003310217 RP003314116 RP003388587 RP003407990 RP003420484 RP003422957 RP003432835 RP003440633 RP003512998 RP003524745 RP003527315 RP003552385 RP003553124 RP003571799 RP003585203 RP003610849 RP003643932 RP003678539
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0003575 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31012
Antibody Information
	polyclonal (Kuan et al., 2009, Voelker et al., 1991, Murray et al., 1997)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: su(s) CG6222 (Nusskern, 1999.11)
Source for database merge of
Additional comments
Other Comments
	"Gene order: In direction of increasing cytology: RpL36+ l(1)1Bi+ Dredd- su(s)+" was stated as revision. (Chen et al., 1998) In a sample of 79 genes with multiple introns, 33 showed significant heterogeneity in G+C content among introns of the same gene and significant positive correspondence between the intron and the third codon position G+C content within genes. These results are consistent with selection adding against preferred codons at the start of genes. (Kliman and Eyre-Walker, 1998) Recombinant su(s) protein is capable of binding RNA, consistent with previous results indicating that su(s) mutations affect mRNA processing (FBrf0051854, FBrf0068496 and FBrf0055001). (Murray et al., 1997) "Gene order: In direction of increasing cytology: RpL36? l(1)1Bi+ Dredd- su(s)+ CG13367? l(1)1Bk?" was stated as revision. (Rodriguez, 1997.9.8) Expression of derivatives of a vs allele with a smaller 412 insertion and alterations in the 412-associated splice sites is examined in su(s) wild type and su(s) mutant backgrounds after germ line transformation. Results provide strong support for a role of the su(s) protein in the pre-mRNA splicing pathway. (Fridell and Searles, 1994) Strains carrying both the v+37 allele and one of three su(s) alleles were used to demonstrate how su(s) mutants affect transcript level of v mutant alleles: increased v mRNA accumulation was observed. (Pret and Searles, 1991) su(s) has been cloned and sequenced. (Voelker et al., 1991) Three alleles of the vermilion gene, containing identically located 412 retrotransposon insertions are suppressed by recessive mutations at the su(s) locus. (Fridell et al., 1990) FlyBase curator comment: Gene order described in this paper is "l(1)1Bi? RpL36+ Dredd- su(s)+ CG13367? l(1)1Bk?". FBrf0098592 subsequently reversed the order of l(1)1Bi and RpL36. (Voelker et al., 1989) Mutant phenotype can be rescued by the introduction of a wild type gene by P element mediated transformation. Recessive mutations at the su(s) locus result in the suppression of second site mutations caused by insertions of the 412-element. (Voelker et al., 1989) In hemizygous or homozygous condition suppresses certain spontaneous alleles that contain 412 insertions at several loci (e.g., v, v2, vk, pr, prbw, sp) or hybrid dysgenesis-induced alleles that contain P element insertions (e.g., snw, y76d28). s is suppressible but does not have a 412 insertion (Searles and Voelker, 1986). bx is caused by a 412 insertion but is not suppressed (Voelker et al., 1989). Not all su(s) alleles suppress all suppressible alleles (Jacobson et al., 1982). Although reported as recessive, some alleles show a slight dominance (Shapard, 1960; Baglioni, 1960). No lethal alleles recovered in a lethal saturation screen of the su(s) region, but a number of X-ray-, EMS- and ENU-induced alleles exhibit sterility or reduced male fertility when reared at 18oC (Voelker et al., 1989). Some alleles cause a slight spreading of the wings, especially in males. Suppression of v and y76d28 occurs by elevating the levels of pseudo-wild-type, presumably translatable, message (Searles, Ruth, Pret, Fridell and Ali, submitted; P. Geyer, V. Corces and M. Green, personal communication). Some alleles enhance some gypsy-caused mutations (Rutledge et al., 1988). A duplication of su(s)+ enhances suppressible pr alleles (Jacobson et al., 1982).
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057406 RefSeq (Proteins) • NP_476754 DDBJ / EMBL / GenBank • AA263667 AAA28920 AAF45534 AAL49185 AL031581 AY071563 BI375271 CAA42010 M57889 X59364 Z32182 Entrez Gene - A searchable database of RefSeq genes. • 31012 UniProtKB/Swiss-Prot • P22293
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, CCCH-type (IPR000571)
Linkouts
	BioGRID - A database of protein and genetic interactions • 57580 DroID - A comprehensive database of gene and protein interactions. • FBgn0003575 DRSC - Results from RNAi screens. • FBgn0003575 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003575 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6222-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0003575 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31012 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31012 modMine - Data generated by the modENCODE project. • FBgn0003575
Synonyms & Secondary IDs ( 7 )
Reported As
Symbol Synonym	CG6222 (Benos, 2000.12.13, Legube et al., 2006, Ni et al., 2010.12.1) EG:115C2.3 (Benos et al., 2001, Benos, 2000.12.13, ) su(s) (Voelker et al., 1989, Kuan et al., 2009, Kuan et al., 2004, Walser et al., 2006, Gay et al., 2007, Mudiganti et al., 2010, Wright, 1987, Yin et al., 2009, Zhou et al., 2008, Japanese National Institute of Genetics, 2012.5.21) su-s (California Institute of Technology, 1940, Padhukasahasram and Rannala, 2011) su-v (Masterson, 1968)
Name Synonym	suppressor of sable (Voelker, 1992.7.23, Kuan et al., 2009, Liu et al., 2008, Wright, 1987) Suppressor of sable (Kuan et al., 2004)
Secondary FlyBase IDs
References ( 112 )
Generate a list of	All references relating to this gene ( 112 )
List References by type	Research paper  ( 75 ) Supplementary material  ( 4 ) Review  ( 2 ) Personal communication to FlyBase  ( 10 ) Abstract  ( 6 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 4 ) Stock list  ( 1 ) Curated genome annotation  ( 3 ) Protein sequence record  ( 1 ) Book  ( 2 ) Thesis  ( 1 )
Recent research papers ( 1 )
	Padhukasahasram and Rannala, 2011, Genetics 189(2): 607--619 Bayesian population genomic inference of crossing over and gene conversion. [FBrf0216405] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...