su(s), EG:115C2.3 , su-s
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.50
1322 (aa); 150 (kD observed)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\su(sable) using the Feature Mapper tool.
su(s) protein is detected in a reticulated pattern in embryonic nuclei. A similar reticulated pattern is observed in larval salivary gland nuclei.
su(s) protein is detected in a reticulated pattern in embryonic and salivary gland nuclei. In the salivary gland the staining localizes mainly to the nucleoplasm. Fewer than 20 sites on salivary gland chromosomes stain strongly with anti-su(s) antibody, and a larger number of sites stain weakly. Most chromosome puffs do not stain strongly. Many (but not all) sites that stain with anti-su(s) antibody also stain with anti-snRNP-U1-70K antibody.
GBrowse - Visual display of RNA-Seq signalsView Dmel\su(sable) in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
The gene symbol "su(s)" has been changed to "su(sable)" in order to reduce confusion with the "Su(S)" ("Suppressor of Star") gene symbol, from which it differed only by case.
"Gene order: In direction of increasing cytology: RpL36+ l(1)1Bi+ Dredd- su(s)+" was stated as revision.
In a sample of 79 genes with multiple introns, 33 showed significant heterogeneity in G+C content among introns of the same gene and significant positive correspondence between the intron and the third codon position G+C content within genes. These results are consistent with selection adding against preferred codons at the start of genes.
"Gene order: In direction of increasing cytology: RpL36? l(1)1Bi+ Dredd- su(s)+ CG13367? l(1)1Bk?" was stated as revision.
Expression of derivatives of a vs allele with a smaller 412 insertion and alterations in the 412-associated splice sites is examined in su(s) wild type and su(s) mutant backgrounds after germ line transformation. Results provide strong support for a role of the su(s) protein in the pre-mRNA splicing pathway.
Strains carrying both the v+37 allele and one of three su(s) alleles were used to demonstrate how su(s) mutants affect transcript level of v mutant alleles: increased v mRNA accumulation was observed.
Three alleles of the vermilion gene, containing identically located 412 retrotransposon insertions are suppressed by recessive mutations at the su(s) locus.
Mutant phenotype can be rescued by the introduction of a wild type gene by P element mediated transformation. Recessive mutations at the su(s) locus result in the suppression of second site mutations caused by insertions of the 412-element.
In hemizygous or homozygous condition suppresses certain spontaneous alleles that contain 412 insertions at several loci (e.g., v, v2, vk, pr, prbw, sp) or hybrid dysgenesis-induced alleles that contain P element insertions (e.g., snw, y76d28). s is suppressible but does not have a 412 insertion (Searles and Voelker, 1986). bx is caused by a 412 insertion but is not suppressed (Voelker et al., 1989). Not all su(s) alleles suppress all suppressible alleles (Jacobson et al., 1982). Although reported as recessive, some alleles show a slight dominance (Shapard, 1960; Baglioni, 1960). No lethal alleles recovered in a lethal saturation screen of the su(s) region, but a number of X-ray-, EMS- and ENU-induced alleles exhibit sterility or reduced male fertility when reared at 18oC (Voelker et al., 1989). Some alleles cause a slight spreading of the wings, especially in males. Suppression of v and y76d28 occurs by elevating the levels of pseudo-wild-type, presumably translatable, message (Searles, Ruth, Pret, Fridell and Ali, submitted; P. Geyer, V. Corces and M. Green, personal communication). Some alleles enhance some gypsy-caused mutations (Rutledge et al., 1988). A duplication of su(s)+ enhances suppressible pr alleles (Jacobson et al., 1982).