cry, crystal, SuSte, rasi4, Ste
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Su(Ste) using the Feature Mapper tool.
Su(Ste) transcript is detected in the nuclei of early and mature primary spermatocytes. In early spermatocytes, Su(Ste) transcript has a diffuse nuclear localization, while in mature spermatocytes, transcript is observed in one or two bright discrete dots. The antisense probe does not distinguish between Su(Ste) and Ste transcripts.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Su(Ste) in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: Su(Ste) anon- EST:fe1B7
Repeat-associated small interfering RNAs (rasiRNAs) are produced from the Su(Ste) locus.
Extrachromosomal circular DNA (eccDNA) is present throughout the fly's life cycle. The eccDNA population contains circular multimers of tandemly repeated genes, including Su(Ste).
"Stellate-like" sequences (Ste, Su(Ste), SteXh and Ste12DOR) contain a common region of sequence, defined as the "Stellate-specific central core". Specific regions at either the 5' or 3' end of this core sequence distinguish different Stellate-like sequences from each other.
The high extent of homology between Ste and Su(Ste) repeats suggested a possibility of Ste suppression by antisense transcription of Su(Ste) elements: however the detection of only "sense" Su(Ste) cDNAs in testis cDNA library argues against this proposal.
Su(Ste) genes are transcribed and can encode a variant of the β-subunit of casein kinase 2.
The Su(Ste) locus consists of short subarrays of tandem repeats separated by members of other moderately repeated families. Molecular analysis indicates that recombination among tandem Su(Ste) repeats occurs at much higher frequencies between close neighbors than distant ones, and that gene conversion rather than sister chromatid exchange may be the primary recombinational mechanism for spreading variation among the repeats.
The relationship of Ste copy number and organisation to meiotic behaviour in Su(Ste)- males has been examined genetically and cytologically. Heterochromatic and euchromatic Ste repeats are functional, the abnormalities in chromosome condensation and frequency of nondisjunction is related to the Ste copy number. Meiosis is disrupted after synapsis and Su(Ste) induced meiotic drive is probably not mediated by Ste.
The Su(Ste) tandemly arranged repeat unit consists of a Ste-homologous region, a Y-specific region and an inserted 1360 mobile element. The location of 1360 suggests that the Ste-region and the Y-specific region were joined first, followed by the insertion of the 1360 element and subsequent amplification of the entire structure.
Designates the region of the Y chromosome whose presence decreases both abundance and splicing of the X-linked Ste transcripts. Ste males deficient for Su(Ste) display abundant star-shaped aggregates of needle-shaped crystals in the nuclei and cytoplasm of their primary spermatocytes; their spermatids contain micronuclei and nebenkerne of nonuniform size; and they are sterile. Ste+ males deficient for Su(Ste) have one or more long needle-shaped crystals in their primary spermatocytes and micronuclei and irregular nebenkerne in their spermatids; these males are fertile and display irregular disjunction as follows: (1) both the sex chromosomes and the large autosomes undergo nondisjunction, (2) the fourth chromosomes disjoin regularly, (3) sex chromosome nondisjunction is more frequent in cells in which the second or third chromosomes nondisjoin than in cells in which autosomal disjunction is regular, (4) in doubly exceptional cells, the sex chromosomes tend to segregate to the opposite pole from the autosomes and (5) there is meiotic drive; i.e., reciprocal meiotic products are not recovered with equal frequencies, complements with fewer chromosomes being recovered more frequently than those with more chromosomes. Two smaller component deficiencies of the Su(Ste) deficiency display a normal meiotic phenotype in Ste+ males and low levels of meiotic nondisjunction in Ste males.