General Information
Symbol
Dmel\Su(Ste)
Species
D. melanogaster
Name
Suppressor of Stellate
Annotation Symbol
Feature Type
FlyBase ID
FBgn0003582
Gene Model Status
Stock Availability
Also Known As
cry, SuSte, Ste, rasi4
GO Summary Ribbons
Families, Domains and Molecular Function
Gene Group Membership (FlyBase)
Protein Family (UniProt, Sequence Similarities)
-
Molecular Function (see GO section for details)
Experimental Evidence
-
Predictions / Assertions
Summaries
Phenotypic Description from the Red Book (Lindsley and Zimm 1992)
Su(Ste): Suppressor of Stellate
Designates the region of the Y chromosome whose presence decreases both abundance and splicing of the X-linked Ste transcripts. Ste males deficient for Su(Ste) display abundant star-shaped aggregates of needle-shaped crystals in the nuclei and cytoplasm of their primary spermatocytes; their spermatids contain micronuclei and nebenkerne of nonuniform size; and they are sterile. Ste+ males deficient for Su(Ste) have one or more long needle-shaped crystals in their primary spermatocytes and micronuclei and irregular nebenkerne in their spermatids; these males are fertile and display irregular disjunction as follows: (1) both the sex chromosomes and the large autosomes undergo nondisjunction, (2) the fourth chromosomes disjoin regularly, (3) sex chromosome nondisjunction is more frequent in cells in which the second or third chromosomes nondisjoin than in cells in which autosomal disjunction is regular, (4) in doubly exceptional cells, the sex chromosomes tend to segregate to the opposite pole from the autosomes, and (5) there is meiotic drive; i.e., reciprocal meiotic products are not recovered with equal frequencies, complements with fewer chromosomes being recovered more frequently than those with more chromosomes. Two smaller component deficiencies of the Su(Ste) deficiency display a normal meiotic phenotype in Ste+ males and low levels of meiotic non-disjunction in Ste males.
Gene Model and Products
Number of Transcripts
0
Number of Unique Polypeptides
0

Please see the GBrowse view of Dmel\Su(Ste) or the JBrowse view of Dmel\Su(Ste) for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Polypeptides with Identical Sequences

 

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Su(Ste) using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Gene Ontology (3 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
Biological Process (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
Expression Data
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Su(Ste) transcript is detected in the nuclei of early and mature primary spermatocytes. In early spermatocytes, Su(Ste) transcript has a diffuse nuclear localization, while in mature spermatocytes, transcript is observed in one or two bright discrete dots. The antisense probe does not distinguish between Su(Ste) and Ste transcripts.
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Su(Ste) in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Alleles, Insertions, Transgenic Constructs and Phenotypes
Classical and Insertion Alleles ( 1 )
For All Classical and Insertion Alleles Show
 
Allele of Su(Ste)
Class
Mutagen
Associated Insertion
Stocks
Known lesion
Other relevant insertions
Transgenic Constructs ( 1 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Su(Ste)
Allele of Su(Ste)
Mutagen
Associated Transgenic Construct
Stocks
Transgenic constructs containing regulatory region of Su(Ste)
Deletions and Duplications ( 1 )
Summary of Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (0)
No orthologs reported.
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (0)
No orthologs reported.
Rattus norvegicus (Norway rat) (0)
No orthologs reported.
Xenopus tropicalis (Western clawed frog) (0)
No orthologs reported.
Danio rerio (Zebrafish) (0)
No orthologs reported.
Caenorhabditis elegans (Nematode, roundworm) (0)
No orthologs reported.
Arabidopsis thaliana (thale-cress) (0)
No orthologs reported.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No orthologs reported.
Schizosaccharomyces pombe (Fission yeast) (0)
No orthologs reported.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( None identified )
No orthologies identified
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( None identified )
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( None identified )
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( None identified )
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
No non-Arthropod Metazoa orthologies identified
Human Disease Model Data
FlyBase Human Disease Model Reports
    Alleles Reported to Model Human Disease (Disease Ontology)
    Download
    Models ( 0 )
    Allele
    Disease
    Evidence
    References
    Interactions ( 0 )
    Allele
    Disease
    Interaction
    References
    Comments ( 0 )
     
    Human Orthologs (via DIOPT v7.1)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Interactions Browser
    Summary of Genetic Interactions
    esyN Network Diagram
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    Pathways
    Gene Group - Pathway Membership (FlyBase)
    External Data
    Linkouts
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    Recombination map
    Y-
    Cytogenetic map
    Sequence location
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    h11-h11
    Left limit from sequence databank entry L42286 Right limit from sequence databank entry L42286
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    Experimentally Determined Recombination Data
    Location
    Y-
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (0)
    Genomic Clones (0)
     
      cDNA Clones (0)
       

      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

      cDNA clones, fully sequences
      BDGP DGC clones
        Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

            cDNA Clones, End Sequenced (ESTs)
            BDGP DGC clones
              Other clones
                RNAi and Array Information
                Linkouts
                Antibody Information
                Laboratory Generated Antibodies
                 
                Commercially Available Antibodies
                 
                Other Information
                Relationship to Other Genes
                Source for database identify of
                Source for database merge of
                Source for merge of: Su(Ste) anon- EST:fe1B7
                Additional comments
                Other Comments
                Repeat-associated small interfering RNAs (rasiRNAs) are produced from the Su(Ste) locus.
                Extrachromosomal circular DNA (eccDNA) is present throughout the fly's life cycle. The eccDNA population contains circular multimers of tandemly repeated genes, including Su(Ste).
                "Stellate-like" sequences (Ste, Su(Ste), SteXh and Ste12DOR) contain a common region of sequence, defined as the "Stellate-specific central core". Specific regions at either the 5' or 3' end of this core sequence distinguish different Stellate-like sequences from each other.
                Ste-/Su(Ste)- males have exactly the same meiotic drive phenotype as Ste+/Su(Ste)- males.
                Alternative ways of Su(Ste) transcript processing caused by the divergence of the Su(Ste) repeats have been detected.
                The high extent of homology between Ste and Su(Ste) repeats suggested a possibility of Ste suppression by antisense transcription of Su(Ste) elements: however the detection of only "sense" Su(Ste) cDNAs in testis cDNA library argues against this proposal.
                Su(Ste) genes are transcribed and can encode a variant of the β-subunit of casein kinase 2.
                The Su(Ste) locus consists of short subarrays of tandem repeats separated by members of other moderately repeated families. Molecular analysis indicates that recombination among tandem Su(Ste) repeats occurs at much higher frequencies between close neighbors than distant ones, and that gene conversion rather than sister chromatid exchange may be the primary recombinational mechanism for spreading variation among the repeats.
                The relationship of Ste copy number and organisation to meiotic behaviour in Su(Ste)- males has been examined genetically and cytologically. Heterochromatic and euchromatic Ste repeats are functional, the abnormalities in chromosome condensation and frequency of nondisjunction is related to the Ste copy number. Meiosis is disrupted after synapsis and Su(Ste) induced meiotic drive is probably not mediated by Ste.
                The Su(Ste) tandemly arranged repeat unit consists of a Ste-homologous region, a Y-specific region and an inserted 1360 mobile element. The location of 1360 suggests that the Ste-region and the Y-specific region were joined first, followed by the insertion of the 1360 element and subsequent amplification of the entire structure.
                Designates the region of the Y chromosome whose presence decreases both abundance and splicing of the X-linked Ste transcripts. Ste males deficient for Su(Ste) display abundant star-shaped aggregates of needle-shaped crystals in the nuclei and cytoplasm of their primary spermatocytes; their spermatids contain micronuclei and nebenkerne of nonuniform size; and they are sterile. Ste+ males deficient for Su(Ste) have one or more long needle-shaped crystals in their primary spermatocytes and micronuclei and irregular nebenkerne in their spermatids; these males are fertile and display irregular disjunction as follows: (1) both the sex chromosomes and the large autosomes undergo nondisjunction, (2) the fourth chromosomes disjoin regularly, (3) sex chromosome nondisjunction is more frequent in cells in which the second or third chromosomes nondisjoin than in cells in which autosomal disjunction is regular, (4) in doubly exceptional cells, the sex chromosomes tend to segregate to the opposite pole from the autosomes and (5) there is meiotic drive; i.e., reciprocal meiotic products are not recovered with equal frequencies, complements with fewer chromosomes being recovered more frequently than those with more chromosomes. Two smaller component deficiencies of the Su(Ste) deficiency display a normal meiotic phenotype in Ste+ males and low levels of meiotic nondisjunction in Ste males.
                Analysis using segmental Y deficiencies shows that Su(Ste) represses both the high levels and efficient splicing of Ste RNA.
                Origin and Etymology
                Discoverer
                Etymology
                Identification
                External Crossreferences and Linkouts ( 18 )
                Crossreferences
                GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                Other crossreferences
                Synonyms and Secondary IDs (20)
                Reported As
                Secondary FlyBase IDs
                • FBgn0025265
                • FBgn0005668
                Datasets (0)
                Study focus (0)
                Experimental Role
                Project
                Project Type
                Title
                References (129)