General Information Symbol Dmel\ Su(var)3-7Species D. melanogaster Name Suppressor of variegation 3-7 Annotation symbol CG8599 Feature type protein_coding_gene FlyBase ID FBgn0003598 Gene Model Status Current Stock availability 4 publicly
available Also Known As Suvar(3)7, Su-var(3)7 Genomic Location Chromosome (arm) 3R Recombination map 3-50.9 Cytogenetic map 87E3-87E3 Sequence location 3R:9,090,086..9,095,760 [+]
Genomic Maps
Summary Information Automatically generated summary
See sections below for more information The gene
Suppressor of variegation 3-7 is referred to in FlyBase by the symbol
Dmel\Su(var)3-7 (CG8599, FBgn0003598). It is a protein_coding_gene from
Drosophila melanogaster . There is experimental evidence that it has the
molecular function : protein binding; chromatin binding. There is experimental evidence that it is involved in the
biological process : dosage compensation by inactivation of X chromosome; positive regulation of chromatin silencing at centromere.
51 alleles are reported . The
phenotypes of these alleles are annotated with: macrochaeta; humeral bristle; sex comb; wing; ommatidium; polytene chromosome chromocenter; prothoracic gland. It has
2 annotated transcripts and
2 annotated polypeptides .
Protein features are: BESS motif; Zinc finger, C2H2-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1626862_at completely aligns to an exonic region of only a subset of 1 of the 2 FlyBase-annotated transcript isoforms of Su(var)3-7. Gene sequence location is
3R:9090086..9095760 .
User Contributed Data External Summaries
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Detailed Mapping Data
FlyBase Computed Cytological Location
Experimentally Determined Cytological Location
87E-87E
(determined by in situ hybridisation)
87E4-87E5
Location based on deficiency mapping. (determined by in situ hybridisation)
Experimentally Determined Recombination Data
Location Left of (cM) Right of (cM) Notes Gene Model & Products Comments on Gene
Model Gene model reviewed during 5.47
Transcript Data Annotated Transcripts Additional Transcript Data
& Comments Reported size (kB) Comments External Data Crossreferences
Polypeptide Data Annotated
Polypeptides Additional Polypeptide
Data & Comments Reported size (kDa) Comments External Data Linkouts Crossreferences
domains - A database of protein families, domains, and functional sites
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank UniProtKB/Swiss-Prot UniProtKB/TrEMBL Mapped Features Mapped Features have been reorganized, please
see this article for details. Additional mapped features and mutations can
be found on GBrowse or related reports. External Data Linkouts Crossreferences Expression Data Transcript ExpressionComment: maternally deposited
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm anlage
Comment: reported as ventral nerve cord anlage
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Additional Descriptive Data
Marker for Subcellular Localization CV Term Polypeptide Expression
Additional Descriptive Data
Marker for Subcellular Localization (GO Cellular Component) inferred from direct assay
inferred from direct assay
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference
FlyAtlas Anatomy Microarray
Linear, scaled to maximum expression level
Tissue
Expression Level
Larval Central Nervous System
58.625
Larval Midgut
5.7
Larval Hindgut
10.8
Larval Malpighian Tubules
7.5
Larval Fat Body
21.2
Larval Salivary Gland
11.1
Larval Trachea
24.8
Larval Carcass
13.15
Adult Head
13.2
Adult Eye
18.05
Adult Brain
37.6
Adult Thoracic-Abdominal Ganglion
36
Adult Crop
13.6
Adult Midgut
7
Adult Hindgut
12
Adult Malpighian Tubules
10.9
Adult Fat Body
14.4
Adult Salivary Gland
8.1
Adult Heart
15.025
Adult VirginFemale Spermatheca
26.7
Adult InseminatedFemale Spermatheca
23
Adult Ovary
30
Adult Testis
2.9
Adult Male Accessory Gland
15.9
Adult Carcass
16.6
Expression Level Scale
None
Low
Linear, scaled to Moderate expression
Tissue
Expression Level
Larval Central Nervous System
58.625
Larval Midgut
5.7
Larval Hindgut
10.8
Larval Malpighian Tubules
7.5
Larval Fat Body
21.2
Larval Salivary Gland
11.1
Larval Trachea
24.8
Larval Carcass
13.15
Adult Head
13.2
Adult Eye
18.05
Adult Brain
37.6
Adult Thoracic-Abdominal Ganglion
36
Adult Crop
13.6
Adult Midgut
7
Adult Hindgut
12
Adult Malpighian Tubules
10.9
Adult Fat Body
14.4
Adult Salivary Gland
8.1
Adult Heart
15.025
Adult VirginFemale Spermatheca
26.7
Adult InseminatedFemale Spermatheca
23
Adult Ovary
30
Adult Testis
2.9
Adult Male Accessory Gland
15.9
Adult Carcass
16.6
Expression Level Scale
None
Low
Moderate
High
Linear, scaled to High level expression
Tissue
Expression Level
Larval Central Nervous System
58.625
Larval Midgut
5.7
Larval Hindgut
10.8
Larval Malpighian Tubules
7.5
Larval Fat Body
21.2
Larval Salivary Gland
11.1
Larval Trachea
24.8
Larval Carcass
13.15
Adult Head
13.2
Adult Eye
18.05
Adult Brain
37.6
Adult Thoracic-Abdominal Ganglion
36
Adult Crop
13.6
Adult Midgut
7
Adult Hindgut
12
Adult Malpighian Tubules
10.9
Adult Fat Body
14.4
Adult Salivary Gland
8.1
Adult Heart
15.025
Adult VirginFemale Spermatheca
26.7
Adult InseminatedFemale Spermatheca
23
Adult Ovary
30
Adult Testis
2.9
Adult Male Accessory Gland
15.9
Adult Carcass
16.6
Expression Level Scale
None
Low
Moderate
High
Very high
Linear, scaled to Very high expression
Tissue
Expression Level
Larval Central Nervous System
58.625
Larval Midgut
5.7
Larval Hindgut
10.8
Larval Malpighian Tubules
7.5
Larval Fat Body
21.2
Larval Salivary Gland
11.1
Larval Trachea
24.8
Larval Carcass
13.15
Adult Head
13.2
Adult Eye
18.05
Adult Brain
37.6
Adult Thoracic-Abdominal Ganglion
36
Adult Crop
13.6
Adult Midgut
7
Adult Hindgut
12
Adult Malpighian Tubules
10.9
Adult Fat Body
14.4
Adult Salivary Gland
8.1
Adult Heart
15.025
Adult VirginFemale Spermatheca
26.7
Adult InseminatedFemale Spermatheca
23
Adult Ovary
30
Adult Testis
2.9
Adult Male Accessory Gland
15.9
Adult Carcass
16.6
Expression Level Scale
Very high
log, scaled to maximum expression level
Tissue
Expression Level
Larval Central Nervous System
58.625
Larval Midgut
5.7
Larval Hindgut
10.8
Larval Malpighian Tubules
7.5
Larval Fat Body
21.2
Larval Salivary Gland
11.1
Larval Trachea
24.8
Larval Carcass
13.15
Adult Head
13.2
Adult Eye
18.05
Adult Brain
37.6
Adult Thoracic-Abdominal Ganglion
36
Adult Crop
13.6
Adult Midgut
7
Adult Hindgut
12
Adult Malpighian Tubules
10.9
Adult Fat Body
14.4
Adult Salivary Gland
8.1
Adult Heart
15.025
Adult VirginFemale Spermatheca
26.7
Adult InseminatedFemale Spermatheca
23
Adult Ovary
30
Adult Testis
2.9
Adult Male Accessory Gland
15.9
Adult Carcass
16.6
Expression Level Scale
None
Low
log, scaled to Moderate expression
Tissue
Expression Level
Larval Central Nervous System
58.625
Larval Midgut
5.7
Larval Hindgut
10.8
Larval Malpighian Tubules
7.5
Larval Fat Body
21.2
Larval Salivary Gland
11.1
Larval Trachea
24.8
Larval Carcass
13.15
Adult Head
13.2
Adult Eye
18.05
Adult Brain
37.6
Adult Thoracic-Abdominal Ganglion
36
Adult Crop
13.6
Adult Midgut
7
Adult Hindgut
12
Adult Malpighian Tubules
10.9
Adult Fat Body
14.4
Adult Salivary Gland
8.1
Adult Heart
15.025
Adult VirginFemale Spermatheca
26.7
Adult InseminatedFemale Spermatheca
23
Adult Ovary
30
Adult Testis
2.9
Adult Male Accessory Gland
15.9
Adult Carcass
16.6
Expression Level Scale
None
Low
Moderate
High
log, scaled to High level expression
Tissue
Expression Level
Larval Central Nervous System
58.625
Larval Midgut
5.7
Larval Hindgut
10.8
Larval Malpighian Tubules
7.5
Larval Fat Body
21.2
Larval Salivary Gland
11.1
Larval Trachea
24.8
Larval Carcass
13.15
Adult Head
13.2
Adult Eye
18.05
Adult Brain
37.6
Adult Thoracic-Abdominal Ganglion
36
Adult Crop
13.6
Adult Midgut
7
Adult Hindgut
12
Adult Malpighian Tubules
10.9
Adult Fat Body
14.4
Adult Salivary Gland
8.1
Adult Heart
15.025
Adult VirginFemale Spermatheca
26.7
Adult InseminatedFemale Spermatheca
23
Adult Ovary
30
Adult Testis
2.9
Adult Male Accessory Gland
15.9
Adult Carcass
16.6
Expression Level Scale
None
Low
Moderate
High
Very high
log, scaled to Very high expression
Tissue
Expression Level
Larval Central Nervous System
58.625
Larval Midgut
5.7
Larval Hindgut
10.8
Larval Malpighian Tubules
7.5
Larval Fat Body
21.2
Larval Salivary Gland
11.1
Larval Trachea
24.8
Larval Carcass
13.15
Adult Head
13.2
Adult Eye
18.05
Adult Brain
37.6
Adult Thoracic-Abdominal Ganglion
36
Adult Crop
13.6
Adult Midgut
7
Adult Hindgut
12
Adult Malpighian Tubules
10.9
Adult Fat Body
14.4
Adult Salivary Gland
8.1
Adult Heart
15.025
Adult VirginFemale Spermatheca
26.7
Adult InseminatedFemale Spermatheca
23
Adult Ovary
30
Adult Testis
2.9
Adult Male Accessory Gland
15.9
Adult Carcass
16.6
Expression Level Scale
None
Low
Moderate
High
Very high
Heatmap
Tissue
Expression Level
Larval Central Nervous System
Larval Midgut
Larval Hindgut
Larval Malpighian Tubules
Larval Fat Body
Larval Salivary Gland
Larval Trachea
Larval Carcass
Adult Head
Adult Eye
Adult Brain
Adult Thoracic-Abdominal Ganglion
Adult Crop
Adult Midgut
Adult Hindgut
Adult Malpighian Tubules
Adult Fat Body
Adult Salivary Gland
Adult Heart
Adult VirginFemale Spermatheca
Adult InseminatedFemale Spermatheca
Adult Ovary
Adult Testis
Adult Male Accessory Gland
Adult Carcass
FlyAtlas Organ/Tissue Expression, larval vs. adult
Larval Expression Level
Tissue
Adult Expression Level
NA
Head
13.2
NA
Eye
18.05
NA
Brain
37.6
58.625
Central Nervous System
NA
NA
Thoracic-Abdominal Ganglion
36
NA
Crop
13.6
5.7
Midgut
7
10.8
Hindgut
12
7.5
Malpighian Tubules
no informative data
21.2
Fat Body
14.4
no informative data
Salivary Gland
8.1
NA
Heart
15.025
24.8
Trachea
NA
NA
VirginFemale Spermatheca
26.7
NA
InseminatedFemale Spermatheca
23
NA
Ovary
30
NA
Testis
2.9
NA
Male Accessory Gland
no informative data
no informative data
Carcass
16.6
modENCODE Anatomy RNA-Seq
Linear, scaled to maximum expression level
Tissue
Expression Level
imaginal disc, larvae L3 wandering
24
central nervous system, larvae L3
35
central nervous system, pupae P8
18
head, virgin 1-day female
6
head, virgin 4-day female
8
head, virgin 20-day female
5
head, mated 1-day female
8
head, mated 4-day female
8
head, mated 20-day female
6
head, mated 1-day male
10
head, mated 4-day male
10
head, mated 20-day male
12
salivary gland, larvae L3 wandering
1
salivary gland, white prepupae
4
digestive system, larvae L3 wandering
5
digestive system, 1-day adult
3
digestive system, 4-day adult
8
digestive system, 20-day adult
5
fat body, larvae L3 wandering
4
fat body, white prepupae
8
fat body, pupae P8
11
carcass, larvae L3 wandering
19
carcass, 1-day adult
5
carcass, 4-day adult
9
carcass, 20-day adult
7
ovary, virgin 4-day female
107
ovary, mated 4-day female
115
testis, mated 4-day male
9
accessory gland, mated 4-day male
5
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Moderate expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
24
central nervous system, larvae L3
(35)
central nervous system, pupae P8
18
head, virgin 1-day female
6
head, virgin 4-day female
8
head, virgin 20-day female
5
head, mated 1-day female
8
head, mated 4-day female
8
head, mated 20-day female
6
head, mated 1-day male
10
head, mated 4-day male
10
head, mated 20-day male
12
salivary gland, larvae L3 wandering
1
salivary gland, white prepupae
4
digestive system, larvae L3 wandering
5
digestive system, 1-day adult
3
digestive system, 4-day adult
8
digestive system, 20-day adult
5
fat body, larvae L3 wandering
4
fat body, white prepupae
8
fat body, pupae P8
11
carcass, larvae L3 wandering
19
carcass, 1-day adult
5
carcass, 4-day adult
9
carcass, 20-day adult
7
ovary, virgin 4-day female
(107)
ovary, mated 4-day female
(115)
testis, mated 4-day male
9
accessory gland, mated 4-day male
5
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to High expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
24
central nervous system, larvae L3
35
central nervous system, pupae P8
18
head, virgin 1-day female
6
head, virgin 4-day female
8
head, virgin 20-day female
5
head, mated 1-day female
8
head, mated 4-day female
8
head, mated 20-day female
6
head, mated 1-day male
10
head, mated 4-day male
10
head, mated 20-day male
12
salivary gland, larvae L3 wandering
1
salivary gland, white prepupae
4
digestive system, larvae L3 wandering
5
digestive system, 1-day adult
3
digestive system, 4-day adult
8
digestive system, 20-day adult
5
fat body, larvae L3 wandering
4
fat body, white prepupae
8
fat body, pupae P8
11
carcass, larvae L3 wandering
19
carcass, 1-day adult
5
carcass, 4-day adult
9
carcass, 20-day adult
7
ovary, virgin 4-day female
107
ovary, mated 4-day female
(115)
testis, mated 4-day male
9
accessory gland, mated 4-day male
5
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Extremely high expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
24
central nervous system, larvae L3
35
central nervous system, pupae P8
18
head, virgin 1-day female
6
head, virgin 4-day female
8
head, virgin 20-day female
5
head, mated 1-day female
8
head, mated 4-day female
8
head, mated 20-day female
6
head, mated 1-day male
10
head, mated 4-day male
10
head, mated 20-day male
12
salivary gland, larvae L3 wandering
1
salivary gland, white prepupae
4
digestive system, larvae L3 wandering
5
digestive system, 1-day adult
3
digestive system, 4-day adult
8
digestive system, 20-day adult
5
fat body, larvae L3 wandering
4
fat body, white prepupae
8
fat body, pupae P8
11
carcass, larvae L3 wandering
19
carcass, 1-day adult
5
carcass, 4-day adult
9
carcass, 20-day adult
7
ovary, virgin 4-day female
107
ovary, mated 4-day female
115
testis, mated 4-day male
9
accessory gland, mated 4-day male
5
Expression Level Scale
Extremely high
log, scaled to maximum expression level
Tissue
Expression Level
imaginal disc, larvae L3 wandering
24
central nervous system, larvae L3
35
central nervous system, pupae P8
18
head, virgin 1-day female
6
head, virgin 4-day female
8
head, virgin 20-day female
5
head, mated 1-day female
8
head, mated 4-day female
8
head, mated 20-day female
6
head, mated 1-day male
10
head, mated 4-day male
10
head, mated 20-day male
12
salivary gland, larvae L3 wandering
1
salivary gland, white prepupae
4
digestive system, larvae L3 wandering
5
digestive system, 1-day adult
3
digestive system, 4-day adult
8
digestive system, 20-day adult
5
fat body, larvae L3 wandering
4
fat body, white prepupae
8
fat body, pupae P8
11
carcass, larvae L3 wandering
19
carcass, 1-day adult
5
carcass, 4-day adult
9
carcass, 20-day adult
7
ovary, virgin 4-day female
107
ovary, mated 4-day female
115
testis, mated 4-day male
9
accessory gland, mated 4-day male
5
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Moderate expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
24
central nervous system, larvae L3
(35)
central nervous system, pupae P8
18
head, virgin 1-day female
6
head, virgin 4-day female
8
head, virgin 20-day female
5
head, mated 1-day female
8
head, mated 4-day female
8
head, mated 20-day female
6
head, mated 1-day male
10
head, mated 4-day male
10
head, mated 20-day male
12
salivary gland, larvae L3 wandering
1
salivary gland, white prepupae
4
digestive system, larvae L3 wandering
5
digestive system, 1-day adult
3
digestive system, 4-day adult
8
digestive system, 20-day adult
5
fat body, larvae L3 wandering
4
fat body, white prepupae
8
fat body, pupae P8
11
carcass, larvae L3 wandering
19
carcass, 1-day adult
5
carcass, 4-day adult
9
carcass, 20-day adult
7
ovary, virgin 4-day female
(107)
ovary, mated 4-day female
(115)
testis, mated 4-day male
9
accessory gland, mated 4-day male
5
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to High expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
24
central nervous system, larvae L3
35
central nervous system, pupae P8
18
head, virgin 1-day female
6
head, virgin 4-day female
8
head, virgin 20-day female
5
head, mated 1-day female
8
head, mated 4-day female
8
head, mated 20-day female
6
head, mated 1-day male
10
head, mated 4-day male
10
head, mated 20-day male
12
salivary gland, larvae L3 wandering
1
salivary gland, white prepupae
4
digestive system, larvae L3 wandering
5
digestive system, 1-day adult
3
digestive system, 4-day adult
8
digestive system, 20-day adult
5
fat body, larvae L3 wandering
4
fat body, white prepupae
8
fat body, pupae P8
11
carcass, larvae L3 wandering
19
carcass, 1-day adult
5
carcass, 4-day adult
9
carcass, 20-day adult
7
ovary, virgin 4-day female
107
ovary, mated 4-day female
115
testis, mated 4-day male
9
accessory gland, mated 4-day male
5
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Extremely high expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
24
central nervous system, larvae L3
35
central nervous system, pupae P8
18
head, virgin 1-day female
6
head, virgin 4-day female
8
head, virgin 20-day female
5
head, mated 1-day female
8
head, mated 4-day female
8
head, mated 20-day female
6
head, mated 1-day male
10
head, mated 4-day male
10
head, mated 20-day male
12
salivary gland, larvae L3 wandering
1
salivary gland, white prepupae
4
digestive system, larvae L3 wandering
5
digestive system, 1-day adult
3
digestive system, 4-day adult
8
digestive system, 20-day adult
5
fat body, larvae L3 wandering
4
fat body, white prepupae
8
fat body, pupae P8
11
carcass, larvae L3 wandering
19
carcass, 1-day adult
5
carcass, 4-day adult
9
carcass, 20-day adult
7
ovary, virgin 4-day female
107
ovary, mated 4-day female
115
testis, mated 4-day male
9
accessory gland, mated 4-day male
5
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
Heatmap
Tissue
Expression Level
imaginal disc, larvae L3 wandering
central nervous system, larvae L3
central nervous system, pupae P8
head, virgin 1-day female
head, virgin 4-day female
head, virgin 20-day female
head, mated 1-day female
head, mated 4-day female
head, mated 20-day female
head, mated 1-day male
head, mated 4-day male
head, mated 20-day male
salivary gland, larvae L3 wandering
salivary gland, white prepupae
digestive system, larvae L3 wandering
digestive system, 1-day adult
digestive system, 4-day adult
digestive system, 20-day adult
fat body, larvae L3 wandering
fat body, white prepupae
fat body, pupae P8
carcass, larvae L3 wandering
carcass, 1-day adult
carcass, 4-day adult
carcass, 20-day adult
ovary, virgin 4-day female
ovary, mated 4-day female
testis, mated 4-day male
accessory gland, mated 4-day male
modENCODE Development RNA-Seq
Linear, scaled to maximum expression level
Developmental Stage
Expression Level
embryo 00-02hr
103
embryo 02-04hr
108
embryo 04-06hr
59
embryo 06-08hr
49
embryo 08-10hr
53
embryo 10-12hr
33
embryo 12-14hr
30
embryo 14-16hr
34
embryo 16-18hr
26
embryo 18-20hr
13
embryo 20-22hr
33
embryo 22-24hr
30
larva L1
6
larva L2
6
larva L3 12hr old
5
larva L3 puffstage 1-2
7
larva L3 puffstage 3-6
12
larva L3 puffstage 7-9
12
white prepupae new
13
white prepupae 12hr
16
white prepupae 24hr
19
pupae 2d postWPP
13
pupae 3d postWPP
7
pupae 4d postWPP
5
adult male 01day
6
adult male 05day
8
adult male 30day
8
adult female 01day
25
adult female 05day
52
adult female 30day
52
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Moderate expression
Developmental Stage
Expression Level
embryo 00-02hr
(103)
embryo 02-04hr
(108)
embryo 04-06hr
(59)
embryo 06-08hr
(49)
embryo 08-10hr
(53)
embryo 10-12hr
(33)
embryo 12-14hr
(30)
embryo 14-16hr
(34)
embryo 16-18hr
26
embryo 18-20hr
13
embryo 20-22hr
(33)
embryo 22-24hr
(30)
larva L1
6
larva L2
6
larva L3 12hr old
5
larva L3 puffstage 1-2
7
larva L3 puffstage 3-6
12
larva L3 puffstage 7-9
12
white prepupae new
13
white prepupae 12hr
16
white prepupae 24hr
19
pupae 2d postWPP
13
pupae 3d postWPP
7
pupae 4d postWPP
5
adult male 01day
6
adult male 05day
8
adult male 30day
8
adult female 01day
25
adult female 05day
(52)
adult female 30day
(52)
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to High expression
Developmental Stage
Expression Level
embryo 00-02hr
103
embryo 02-04hr
(108)
embryo 04-06hr
59
embryo 06-08hr
49
embryo 08-10hr
53
embryo 10-12hr
33
embryo 12-14hr
30
embryo 14-16hr
34
embryo 16-18hr
26
embryo 18-20hr
13
embryo 20-22hr
33
embryo 22-24hr
30
larva L1
6
larva L2
6
larva L3 12hr old
5
larva L3 puffstage 1-2
7
larva L3 puffstage 3-6
12
larva L3 puffstage 7-9
12
white prepupae new
13
white prepupae 12hr
16
white prepupae 24hr
19
pupae 2d postWPP
13
pupae 3d postWPP
7
pupae 4d postWPP
5
adult male 01day
6
adult male 05day
8
adult male 30day
8
adult female 01day
25
adult female 05day
52
adult female 30day
52
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Extremely high expression
Developmental Stage
Expression Level
embryo 00-02hr
103
embryo 02-04hr
108
embryo 04-06hr
59
embryo 06-08hr
49
embryo 08-10hr
53
embryo 10-12hr
33
embryo 12-14hr
30
embryo 14-16hr
34
embryo 16-18hr
26
embryo 18-20hr
13
embryo 20-22hr
33
embryo 22-24hr
30
larva L1
6
larva L2
6
larva L3 12hr old
5
larva L3 puffstage 1-2
7
larva L3 puffstage 3-6
12
larva L3 puffstage 7-9
12
white prepupae new
13
white prepupae 12hr
16
white prepupae 24hr
19
pupae 2d postWPP
13
pupae 3d postWPP
7
pupae 4d postWPP
5
adult male 01day
6
adult male 05day
8
adult male 30day
8
adult female 01day
25
adult female 05day
52
adult female 30day
52
Expression Level Scale
Extremely high
log, scaled to maximum expression level
Developmental Stage
Expression Level
embryo 00-02hr
103
embryo 02-04hr
108
embryo 04-06hr
59
embryo 06-08hr
49
embryo 08-10hr
53
embryo 10-12hr
33
embryo 12-14hr
30
embryo 14-16hr
34
embryo 16-18hr
26
embryo 18-20hr
13
embryo 20-22hr
33
embryo 22-24hr
30
larva L1
6
larva L2
6
larva L3 12hr old
5
larva L3 puffstage 1-2
7
larva L3 puffstage 3-6
12
larva L3 puffstage 7-9
12
white prepupae new
13
white prepupae 12hr
16
white prepupae 24hr
19
pupae 2d postWPP
13
pupae 3d postWPP
7
pupae 4d postWPP
5
adult male 01day
6
adult male 05day
8
adult male 30day
8
adult female 01day
25
adult female 05day
52
adult female 30day
52
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Moderate expression
Developmental Stage
Expression Level
embryo 00-02hr
(103)
embryo 02-04hr
(108)
embryo 04-06hr
(59)
embryo 06-08hr
(49)
embryo 08-10hr
(53)
embryo 10-12hr
(33)
embryo 12-14hr
30
embryo 14-16hr
(34)
embryo 16-18hr
26
embryo 18-20hr
13
embryo 20-22hr
(33)
embryo 22-24hr
30
larva L1
6
larva L2
6
larva L3 12hr old
5
larva L3 puffstage 1-2
7
larva L3 puffstage 3-6
12
larva L3 puffstage 7-9
12
white prepupae new
13
white prepupae 12hr
16
white prepupae 24hr
19
pupae 2d postWPP
13
pupae 3d postWPP
7
pupae 4d postWPP
5
adult male 01day
6
adult male 05day
8
adult male 30day
8
adult female 01day
25
adult female 05day
(52)
adult female 30day
(52)
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to High expression
Developmental Stage
Expression Level
embryo 00-02hr
103
embryo 02-04hr
108
embryo 04-06hr
59
embryo 06-08hr
49
embryo 08-10hr
53
embryo 10-12hr
33
embryo 12-14hr
30
embryo 14-16hr
34
embryo 16-18hr
26
embryo 18-20hr
13
embryo 20-22hr
33
embryo 22-24hr
30
larva L1
6
larva L2
6
larva L3 12hr old
5
larva L3 puffstage 1-2
7
larva L3 puffstage 3-6
12
larva L3 puffstage 7-9
12
white prepupae new
13
white prepupae 12hr
16
white prepupae 24hr
19
pupae 2d postWPP
13
pupae 3d postWPP
7
pupae 4d postWPP
5
adult male 01day
6
adult male 05day
8
adult male 30day
8
adult female 01day
25
adult female 05day
52
adult female 30day
52
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Extremely high expression
Developmental Stage
Expression Level
embryo 00-02hr
103
embryo 02-04hr
108
embryo 04-06hr
59
embryo 06-08hr
49
embryo 08-10hr
53
embryo 10-12hr
33
embryo 12-14hr
30
embryo 14-16hr
34
embryo 16-18hr
26
embryo 18-20hr
13
embryo 20-22hr
33
embryo 22-24hr
30
larva L1
6
larva L2
6
larva L3 12hr old
5
larva L3 puffstage 1-2
7
larva L3 puffstage 3-6
12
larva L3 puffstage 7-9
12
white prepupae new
13
white prepupae 12hr
16
white prepupae 24hr
19
pupae 2d postWPP
13
pupae 3d postWPP
7
pupae 4d postWPP
5
adult male 01day
6
adult male 05day
8
adult male 30day
8
adult female 01day
25
adult female 05day
52
adult female 30day
52
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
Heatmap
Developmental Stage
Expression Level
embryo 00-02hr
embryo 02-04hr
embryo 04-06hr
embryo 06-08hr
embryo 08-10hr
embryo 10-12hr
embryo 12-14hr
embryo 14-16hr
embryo 16-18hr
embryo 18-20hr
embryo 20-22hr
embryo 22-24hr
larva L1
larva L2
larva L3 12hr old
larva L3 puffstage 1-2
larva L3 puffstage 3-6
larva L3 puffstage 7-9
white prepupae new
white prepupae 12hr
white prepupae 24hr
pupae 2d postWPP
pupae 3d postWPP
pupae 4d postWPP
adult male 01day
adult male 05day
adult male 30day
adult female 01day
adult female 05day
adult female 30day
modENCODE Cell Lines RNA-Seq
Linear, scaled to maximum expression level
Cell Line
Expression Level
Schneider line 2 S2R+
17
Schneider line 2 Sg4
14
embryonic 1182-4H
17
embryonic GM2
16
embryonic Kc167
11
embryonic S1
26
embryonic S3
14
leg disc CME L1
18
wing disc CME-W2
14
wing disc ML-DmD8
18
wing disc ML-DmD9
21
wing disc ML-DmD16-c3
26
wing disc ML-DmD21
14
wing disc ML-DmD32
18
haltere disc ML-DmD17-c3
25
eye-antennal disc ML-DmD11
14
antennal disc ML-DmD20-c5
13
mixed discs ML-DmD4-c1
19
CNS ML-DmBG1-c1
20
CNS ML-DmBG2-c2
16
tumorous blood cells mbn2
12
ovary fGS/OSS
51
ovary OSC
35
ovary OSS
22
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Linear, scaled to Moderate expression
Cell Line
Expression Level
Schneider line 2 S2R+
17
Schneider line 2 Sg4
14
embryonic 1182-4H
17
embryonic GM2
16
embryonic Kc167
11
embryonic S1
26
embryonic S3
14
leg disc CME L1
18
wing disc CME-W2
14
wing disc ML-DmD8
18
wing disc ML-DmD9
21
wing disc ML-DmD16-c3
26
wing disc ML-DmD21
14
wing disc ML-DmD32
18
haltere disc ML-DmD17-c3
25
eye-antennal disc ML-DmD11
14
antennal disc ML-DmD20-c5
13
mixed discs ML-DmD4-c1
19
CNS ML-DmBG1-c1
20
CNS ML-DmBG2-c2
16
tumorous blood cells mbn2
12
ovary fGS/OSS
(51)
ovary OSC
(35)
ovary OSS
22
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to High expression
Cell Line
Expression Level
Schneider line 2 S2R+
17
Schneider line 2 Sg4
14
embryonic 1182-4H
17
embryonic GM2
16
embryonic Kc167
11
embryonic S1
26
embryonic S3
14
leg disc CME L1
18
wing disc CME-W2
14
wing disc ML-DmD8
18
wing disc ML-DmD9
21
wing disc ML-DmD16-c3
26
wing disc ML-DmD21
14
wing disc ML-DmD32
18
haltere disc ML-DmD17-c3
25
eye-antennal disc ML-DmD11
14
antennal disc ML-DmD20-c5
13
mixed discs ML-DmD4-c1
19
CNS ML-DmBG1-c1
20
CNS ML-DmBG2-c2
16
tumorous blood cells mbn2
12
ovary fGS/OSS
51
ovary OSC
35
ovary OSS
22
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Extremely high expression
Cell Line
Expression Level
Schneider line 2 S2R+
17
Schneider line 2 Sg4
14
embryonic 1182-4H
17
embryonic GM2
16
embryonic Kc167
11
embryonic S1
26
embryonic S3
14
leg disc CME L1
18
wing disc CME-W2
14
wing disc ML-DmD8
18
wing disc ML-DmD9
21
wing disc ML-DmD16-c3
26
wing disc ML-DmD21
14
wing disc ML-DmD32
18
haltere disc ML-DmD17-c3
25
eye-antennal disc ML-DmD11
14
antennal disc ML-DmD20-c5
13
mixed discs ML-DmD4-c1
19
CNS ML-DmBG1-c1
20
CNS ML-DmBG2-c2
16
tumorous blood cells mbn2
12
ovary fGS/OSS
51
ovary OSC
35
ovary OSS
22
Expression Level Scale
Extremely high
log, scaled to maximum expression level
Cell Line
Expression Level
Schneider line 2 S2R+
17
Schneider line 2 Sg4
14
embryonic 1182-4H
17
embryonic GM2
16
embryonic Kc167
11
embryonic S1
26
embryonic S3
14
leg disc CME L1
18
wing disc CME-W2
14
wing disc ML-DmD8
18
wing disc ML-DmD9
21
wing disc ML-DmD16-c3
26
wing disc ML-DmD21
14
wing disc ML-DmD32
18
haltere disc ML-DmD17-c3
25
eye-antennal disc ML-DmD11
14
antennal disc ML-DmD20-c5
13
mixed discs ML-DmD4-c1
19
CNS ML-DmBG1-c1
20
CNS ML-DmBG2-c2
16
tumorous blood cells mbn2
12
ovary fGS/OSS
51
ovary OSC
35
ovary OSS
22
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
log, scaled to Moderate expression
Cell Line
Expression Level
Schneider line 2 S2R+
17
Schneider line 2 Sg4
14
embryonic 1182-4H
17
embryonic GM2
16
embryonic Kc167
11
embryonic S1
26
embryonic S3
14
leg disc CME L1
18
wing disc CME-W2
14
wing disc ML-DmD8
18
wing disc ML-DmD9
21
wing disc ML-DmD16-c3
26
wing disc ML-DmD21
14
wing disc ML-DmD32
18
haltere disc ML-DmD17-c3
25
eye-antennal disc ML-DmD11
14
antennal disc ML-DmD20-c5
13
mixed discs ML-DmD4-c1
19
CNS ML-DmBG1-c1
20
CNS ML-DmBG2-c2
16
tumorous blood cells mbn2
12
ovary fGS/OSS
(51)
ovary OSC
(35)
ovary OSS
22
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to High expression
Cell Line
Expression Level
Schneider line 2 S2R+
17
Schneider line 2 Sg4
14
embryonic 1182-4H
17
embryonic GM2
16
embryonic Kc167
11
embryonic S1
26
embryonic S3
14
leg disc CME L1
18
wing disc CME-W2
14
wing disc ML-DmD8
18
wing disc ML-DmD9
21
wing disc ML-DmD16-c3
26
wing disc ML-DmD21
14
wing disc ML-DmD32
18
haltere disc ML-DmD17-c3
25
eye-antennal disc ML-DmD11
14
antennal disc ML-DmD20-c5
13
mixed discs ML-DmD4-c1
19
CNS ML-DmBG1-c1
20
CNS ML-DmBG2-c2
16
tumorous blood cells mbn2
12
ovary fGS/OSS
51
ovary OSC
35
ovary OSS
22
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Extremely high expression
Cell Line
Expression Level
Schneider line 2 S2R+
17
Schneider line 2 Sg4
14
embryonic 1182-4H
17
embryonic GM2
16
embryonic Kc167
11
embryonic S1
26
embryonic S3
14
leg disc CME L1
18
wing disc CME-W2
14
wing disc ML-DmD8
18
wing disc ML-DmD9
21
wing disc ML-DmD16-c3
26
wing disc ML-DmD21
14
wing disc ML-DmD32
18
haltere disc ML-DmD17-c3
25
eye-antennal disc ML-DmD11
14
antennal disc ML-DmD20-c5
13
mixed discs ML-DmD4-c1
19
CNS ML-DmBG1-c1
20
CNS ML-DmBG2-c2
16
tumorous blood cells mbn2
12
ovary fGS/OSS
51
ovary OSC
35
ovary OSS
22
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
Heatmap
Cell Line
Expression Level
Schneider line 2 S2R+
Schneider line 2 Sg4
embryonic 1182-4H
embryonic GM2
embryonic Kc167
embryonic S1
embryonic S3
leg disc CME L1
wing disc CME-W2
wing disc ML-DmD8
wing disc ML-DmD9
wing disc ML-DmD16-c3
wing disc ML-DmD21
wing disc ML-DmD32
haltere disc ML-DmD17-c3
eye-antennal disc ML-DmD11
antennal disc ML-DmD20-c5
mixed discs ML-DmD4-c1
CNS ML-DmBG1-c1
CNS ML-DmBG2-c2
tumorous blood cells mbn2
ovary fGS/OSS
ovary OSC
ovary OSS
modENCODE Treatments RNA-Seq
Linear, scaled to maximum expression level
Treatment
Expression Level
extended cold, 4-day adult
30
cold shock, 4-day adult
19
heat shock, 4-day adult
25
Cadmium 50 mM 6 hrs, larvae L3
4
Cadmium 50 mM 12 hrs, larvae L3
4
Cadmium 50 mM 48 hrs, 4-day adult
30
Cadmium 100 mM 48 hrs, 4-day adult
78
Copper 0.5 mM 12 hrs, larvae L3
5
Copper 15 mM 48 hrs, 4-day adult
57
Zinc 5 mM 12 hrs, larvae L3
8
Zinc 4.5 mM 48 hrs, 4-day adult
22
Ethanol 2.5% 3 hrs, larvae L3
63
Ethanol 5% 3 hrs, larvae L3
5
Ethanol 10% 3 hrs, larvae L3
5
Caffeine 1.5 mg/ml 4 hrs, larvae L3
5
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
68
Caffeine 25 mg/ml 48 hrs, 4-day adult
35
Paraquat 5 mM 48 hrs, 4-day adult
54
Paraquat 10 mM 48 hrs, 4-day adult
38
Rotenone 2 μg 12 hrs, larvae L3
4
Rotenone 8 μg 12 hrs, larvae L3
3
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Linear, scaled to Moderate expression
Treatment
Expression Level
extended cold, 4-day adult
(30)
cold shock, 4-day adult
19
heat shock, 4-day adult
25
Cadmium 50 mM 6 hrs, larvae L3
4
Cadmium 50 mM 12 hrs, larvae L3
4
Cadmium 50 mM 48 hrs, 4-day adult
(30)
Cadmium 100 mM 48 hrs, 4-day adult
(78)
Copper 0.5 mM 12 hrs, larvae L3
5
Copper 15 mM 48 hrs, 4-day adult
(57)
Zinc 5 mM 12 hrs, larvae L3
8
Zinc 4.5 mM 48 hrs, 4-day adult
22
Ethanol 2.5% 3 hrs, larvae L3
(63)
Ethanol 5% 3 hrs, larvae L3
5
Ethanol 10% 3 hrs, larvae L3
5
Caffeine 1.5 mg/ml 4 hrs, larvae L3
5
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
(68)
Caffeine 25 mg/ml 48 hrs, 4-day adult
(35)
Paraquat 5 mM 48 hrs, 4-day adult
(54)
Paraquat 10 mM 48 hrs, 4-day adult
(38)
Rotenone 2 μg 12 hrs, larvae L3
4
Rotenone 8 μg 12 hrs, larvae L3
3
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to High expression
Treatment
Expression Level
extended cold, 4-day adult
30
cold shock, 4-day adult
19
heat shock, 4-day adult
25
Cadmium 50 mM 6 hrs, larvae L3
4
Cadmium 50 mM 12 hrs, larvae L3
4
Cadmium 50 mM 48 hrs, 4-day adult
30
Cadmium 100 mM 48 hrs, 4-day adult
78
Copper 0.5 mM 12 hrs, larvae L3
5
Copper 15 mM 48 hrs, 4-day adult
57
Zinc 5 mM 12 hrs, larvae L3
8
Zinc 4.5 mM 48 hrs, 4-day adult
22
Ethanol 2.5% 3 hrs, larvae L3
63
Ethanol 5% 3 hrs, larvae L3
5
Ethanol 10% 3 hrs, larvae L3
5
Caffeine 1.5 mg/ml 4 hrs, larvae L3
5
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
68
Caffeine 25 mg/ml 48 hrs, 4-day adult
35
Paraquat 5 mM 48 hrs, 4-day adult
54
Paraquat 10 mM 48 hrs, 4-day adult
38
Rotenone 2 μg 12 hrs, larvae L3
4
Rotenone 8 μg 12 hrs, larvae L3
3
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Extremely high expression
Treatment
Expression Level
extended cold, 4-day adult
30
cold shock, 4-day adult
19
heat shock, 4-day adult
25
Cadmium 50 mM 6 hrs, larvae L3
4
Cadmium 50 mM 12 hrs, larvae L3
4
Cadmium 50 mM 48 hrs, 4-day adult
30
Cadmium 100 mM 48 hrs, 4-day adult
78
Copper 0.5 mM 12 hrs, larvae L3
5
Copper 15 mM 48 hrs, 4-day adult
57
Zinc 5 mM 12 hrs, larvae L3
8
Zinc 4.5 mM 48 hrs, 4-day adult
22
Ethanol 2.5% 3 hrs, larvae L3
63
Ethanol 5% 3 hrs, larvae L3
5
Ethanol 10% 3 hrs, larvae L3
5
Caffeine 1.5 mg/ml 4 hrs, larvae L3
5
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
68
Caffeine 25 mg/ml 48 hrs, 4-day adult
35
Paraquat 5 mM 48 hrs, 4-day adult
54
Paraquat 10 mM 48 hrs, 4-day adult
38
Rotenone 2 μg 12 hrs, larvae L3
4
Rotenone 8 μg 12 hrs, larvae L3
3
Expression Level Scale
Extremely high
log, scaled to maximum expression level
Treatment
Expression Level
extended cold, 4-day adult
30
cold shock, 4-day adult
19
heat shock, 4-day adult
25
Cadmium 50 mM 6 hrs, larvae L3
4
Cadmium 50 mM 12 hrs, larvae L3
4
Cadmium 50 mM 48 hrs, 4-day adult
30
Cadmium 100 mM 48 hrs, 4-day adult
78
Copper 0.5 mM 12 hrs, larvae L3
5
Copper 15 mM 48 hrs, 4-day adult
57
Zinc 5 mM 12 hrs, larvae L3
8
Zinc 4.5 mM 48 hrs, 4-day adult
22
Ethanol 2.5% 3 hrs, larvae L3
63
Ethanol 5% 3 hrs, larvae L3
5
Ethanol 10% 3 hrs, larvae L3
5
Caffeine 1.5 mg/ml 4 hrs, larvae L3
5
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
68
Caffeine 25 mg/ml 48 hrs, 4-day adult
35
Paraquat 5 mM 48 hrs, 4-day adult
54
Paraquat 10 mM 48 hrs, 4-day adult
38
Rotenone 2 μg 12 hrs, larvae L3
4
Rotenone 8 μg 12 hrs, larvae L3
3
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Moderate expression
Treatment
Expression Level
extended cold, 4-day adult
30
cold shock, 4-day adult
19
heat shock, 4-day adult
25
Cadmium 50 mM 6 hrs, larvae L3
4
Cadmium 50 mM 12 hrs, larvae L3
4
Cadmium 50 mM 48 hrs, 4-day adult
30
Cadmium 100 mM 48 hrs, 4-day adult
(78)
Copper 0.5 mM 12 hrs, larvae L3
5
Copper 15 mM 48 hrs, 4-day adult
(57)
Zinc 5 mM 12 hrs, larvae L3
8
Zinc 4.5 mM 48 hrs, 4-day adult
22
Ethanol 2.5% 3 hrs, larvae L3
(63)
Ethanol 5% 3 hrs, larvae L3
5
Ethanol 10% 3 hrs, larvae L3
5
Caffeine 1.5 mg/ml 4 hrs, larvae L3
5
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
(68)
Caffeine 25 mg/ml 48 hrs, 4-day adult
(35)
Paraquat 5 mM 48 hrs, 4-day adult
(54)
Paraquat 10 mM 48 hrs, 4-day adult
(38)
Rotenone 2 μg 12 hrs, larvae L3
4
Rotenone 8 μg 12 hrs, larvae L3
3
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to High expression
Treatment
Expression Level
extended cold, 4-day adult
30
cold shock, 4-day adult
19
heat shock, 4-day adult
25
Cadmium 50 mM 6 hrs, larvae L3
4
Cadmium 50 mM 12 hrs, larvae L3
4
Cadmium 50 mM 48 hrs, 4-day adult
30
Cadmium 100 mM 48 hrs, 4-day adult
78
Copper 0.5 mM 12 hrs, larvae L3
5
Copper 15 mM 48 hrs, 4-day adult
57
Zinc 5 mM 12 hrs, larvae L3
8
Zinc 4.5 mM 48 hrs, 4-day adult
22
Ethanol 2.5% 3 hrs, larvae L3
63
Ethanol 5% 3 hrs, larvae L3
5
Ethanol 10% 3 hrs, larvae L3
5
Caffeine 1.5 mg/ml 4 hrs, larvae L3
5
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
68
Caffeine 25 mg/ml 48 hrs, 4-day adult
35
Paraquat 5 mM 48 hrs, 4-day adult
54
Paraquat 10 mM 48 hrs, 4-day adult
38
Rotenone 2 μg 12 hrs, larvae L3
4
Rotenone 8 μg 12 hrs, larvae L3
3
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Extremely high expression
Treatment
Expression Level
extended cold, 4-day adult
30
cold shock, 4-day adult
19
heat shock, 4-day adult
25
Cadmium 50 mM 6 hrs, larvae L3
4
Cadmium 50 mM 12 hrs, larvae L3
4
Cadmium 50 mM 48 hrs, 4-day adult
30
Cadmium 100 mM 48 hrs, 4-day adult
78
Copper 0.5 mM 12 hrs, larvae L3
5
Copper 15 mM 48 hrs, 4-day adult
57
Zinc 5 mM 12 hrs, larvae L3
8
Zinc 4.5 mM 48 hrs, 4-day adult
22
Ethanol 2.5% 3 hrs, larvae L3
63
Ethanol 5% 3 hrs, larvae L3
5
Ethanol 10% 3 hrs, larvae L3
5
Caffeine 1.5 mg/ml 4 hrs, larvae L3
5
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
68
Caffeine 25 mg/ml 48 hrs, 4-day adult
35
Paraquat 5 mM 48 hrs, 4-day adult
54
Paraquat 10 mM 48 hrs, 4-day adult
38
Rotenone 2 μg 12 hrs, larvae L3
4
Rotenone 8 μg 12 hrs, larvae L3
3
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
Heatmap
Treatment
Expression Level
extended cold, 4-day adult
cold shock, 4-day adult
heat shock, 4-day adult
Cadmium 50 mM 6 hrs, larvae L3
Cadmium 50 mM 12 hrs, larvae L3
Cadmium 50 mM 48 hrs, 4-day adult
Cadmium 100 mM 48 hrs, 4-day adult
Copper 0.5 mM 12 hrs, larvae L3
Copper 15 mM 48 hrs, 4-day adult
Zinc 5 mM 12 hrs, larvae L3
Zinc 4.5 mM 48 hrs, 4-day adult
Ethanol 2.5% 3 hrs, larvae L3
Ethanol 5% 3 hrs, larvae L3
Ethanol 10% 3 hrs, larvae L3
Caffeine 1.5 mg/ml 4 hrs, larvae L3
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
Caffeine 25 mg/ml 48 hrs, 4-day adult
Paraquat 5 mM 48 hrs, 4-day adult
Paraquat 10 mM 48 hrs, 4-day adult
Rotenone 2 μg 12 hrs, larvae L3
Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
A cluster of genes with similar mRNA expression dynamics across development.
External Data & Images
Linkouts
- Cell culture data for RNAi and other high-throughput technologies
- Adult expression by tissue, using Affymetrix Dros2 array
Alleles & Phenotypes Summary of Allele Phenotypes Classical Alleles ( 20 ) For All Classical Alleles Show Alleles Carried on Transgenic Constructs
( 31 ) For All Alleles Carried on Transgenic
Constructs Show Aneuploid Aberrations Disrupted in Duplicated in Not disrupted in Not duplicated in Transgenic Constructs & Insertions
Transgenic Constructs heat-shock construct
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
characterization construct
Insertions insertion of mobile activating element
Gene Ontology: Function, Process
& Cellular Component ( 10 unique terms ) Terms Based on
Experimental Evidence ( 6 terms ) Molecular Function inferred from direct assay
inferred from physical interaction with
Su(var)205 Biological Process inferred from direct assay
inferred from mutant phenotype
Cellular Component inferred from direct assay
inferred from direct assay
Terms Based on Predictions or
Assertions ( 5 terms ) Molecular Function Biological Process ( 0 terms) Cellular Component traceable author statement
traceable author statement
non-traceable author statement
traceable author statement
Sequence Ontology: Class of Gene Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions Interacts with Please look at the allele data
for full details of the genetic interactions
External Data Linkouts
- A database of protein and genetic interactions
- A comprehensive database of gene and protein interactions.
Protein-protein interactions (PPI) from both known and predicted PPI data sets.
Orthologs
OrthoDB Orthologs (13)
- based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
OrthoDB orthology group searches
Drosophila inclusive ortholog search
Dipteran inclusive ortholog search
No orthologs identified
Insect inclusive ortholog search
No orthologs identified
Arthropod inclusive ortholog search
No orthologs identified
Metazoa inclusive ortholog search
No orthologs identified
Orthologs in Drosophila Species
(EOG6F1XNF )
Drosophila melanogaster
fruit fly
Drosophila pseudoobscura pseudoobscura
Y
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (None identified)
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)AAA Orthologs (11)
based on analysis using Dmel annotation version 4.3
Drosophila pseudoobscura pseudoobscura
Stocks & Reagents Stocks Listed in FlyBase ( 4 )Bloomington VDRC Genomic Clones ( 1 )Please Note FlyBase no
longer curates genomic clone accessions so this list
may not be complete
cDNA Clones ( 51 )Please Note This section lists
cDNAs and ESTs that fall within the genomic extent
of the gene model, which may include cDNAs and ESTs
of genes within introns, or of overlapping genes.
Please see
GBrowse for alignment of the cDNAs and ESTs
to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones Other clones cDNA Clones, End Sequenced
(ESTs) BDGP DGC clones Other clones RNAi & Array Information Linkouts
- Results from RNAi screens.
- GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
Antibody Information
Other Information Discoverer Etymology Identification Relationship to Other Genes Source for database identity of Source for database merge of Additional comments Complements all lethals in the region except
Acej41 ;
Acej41 has a weak dominant variegation suppression effect.
Other Comments DNA-protein interactions: genome-wide binding profile assayed for
Su(var)3-7 protein in
Kc167 cells; see
Chromatin_types_NKI collection report. Individual protein-binding experiments listed under "Samples" at GEO_GSE22069 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE22069).
The genomic organisation and pattern of expression of the
Su(var)3-7 locus have been characterised.
Su(var)3-7 is a haplo suppressor and a triplo enhancer. The suppressor effect of
Su(var)3-9 cannot dominate the enhancer effect displayed by two extra doses of
Su(var)3-7 .
Deletion of one wild type copy of Su(var)3-7 reduces
In(1)wm4 position effect variegation and duplication of Su(var)3-7 enhances variegation. A 6.5kb EcoRV gene fragment from Su(var)3-7 is capable of enhancing variegation in a dose-dependent manner.
Duplications of Su(var)3-7 were found to considerably reduce the haplo-abnormal effect of heterozygous Su(var)3-7 point mutations.
External Crossreferences & Linkouts
Sequence Crossreferences
- A searchable database of RefSeq genes.
Other Crossreferences
domains - A database of protein families, domains, and functional sites
- Patterns of gene expression in Drosophila embryogenesis
Linkouts
- A database of protein and genetic interactions
- A comprehensive database of gene and protein interactions.
- Results from RNAi screens.
- Cell culture data for RNAi and other high-throughput technologies
- Adult expression by tissue, using Affymetrix Dros2 array
- Integrated genomics database for Drosophila, Anopheles, and C.elegans
- GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
- A cyberspace guide to Drosophila development and metazoan evolution
Protein-protein interactions (PPI) from both known and predicted PPI data sets.
- Data generated by the modENCODE project.
Synonyms & Secondary IDs
( 11 )Reported As Symbol Synonym Su(var)3-7
(
Nisha et al., 2008 ,
Bayes and Malik, 2007 ,
Doheny et al., 2008 ,
Haynes et al., 2007 ,
Lam et al., 2005 ,
Ronsseray et al., 2008 ,
Minidorff et al., 2007 ,
Josse et al., 2007 ,
Reo et al., 2010 ,
Kallappagoudar et al., 2010 ,
Abramov et al., 2011 ,
Deng et al., 2010 ,
Johansson et al., 2007 ,
Delattre et al., 2004 ,
Spierer et al., 2005 ,
Cleard and Spierer, 2001 ,
Bazin et al., 2004 ,
Menon and Meller, 2009 ,
Balasov, 2002 ,
de Wit et al., 2008 ,
Spierer et al., 2008 ,
Baig et al., 2010 ,
Prabhakaran and Kelley, 2010 ,
Sakoparnig et al., 2012 ,
Japanese National Institute of Genetics, 2012.5.21 )
SU(VAR)3-7
(
Perrini et al., 2004 ,
Grade et al., 2002 ,
Schotta et al., 2001 ,
Straub and Becker, 2007 ,
Grewal and Elgin, 2007 ,
Demakova et al., 2007 ,
Ronsseray et al., 2007 ,
Ronsseray et al., 2007 ,
Li et al., 2002 ,
Andreyeva et al., 2007 ,
Andreyeva et al., 2005 ,
van Steensel et al., 2010 ,
Spierer et al., 2008 ,
Filion et al., 2010 ,
Demakov et al., 2011 )
Suvar(3)7
(
Reuter, 1998.12.3 ,
Peterson and Sapienza, 1993 ,
Spierer et al., 1992 ,
Henikoff, 1996 ,
Cleard et al., 1995 ,
Reuter and Spierer, 1992 ,
Chan et al., 1994 ,
Paro, 1990 ,
Reuter et al., 1990 ,
Spradling and Karpen, 1990 ,
Elgin, 1990 ,
Pardue and Hennig, 1990 )
Name Synonym Suppressor of variegation 3-7
Secondary FlyBase
IDs References ( 121 )Generate a list of List References by type
Recent research papers ( 4 )
Riddle et al., 2012, PLoS Genet. 8(9): e1002954Enrichment of HP1a on Drosophila Chromosome 4 Genes Creates an Alternate Chromatin Structure Critical for Regulation in this Heterochromatic Domain. [FBrf0219520] Sakoparnig et al., 2012, J. Comput. Biol. 19(2): 126--138Binding profiles of chromatin-modifying proteins are predictive for transcriptional activity and promoter-proximal pausing. [FBrf0217402] Abramov et al., 2011, Dokl. Biochem. Biophys. 437(1): 72--76Genetic and molecular analysis of gene trans-inactivation caused by homologous eu-heterochromatic chromosome rearrangement in Drosophila melanogaster. [FBrf0213780] Demakov et al., 2011, BMC Genomics 12: 566Protein composition of interband regions in polytene and cell line chromosomes of Drosophila melanogaster. [FBrf0216974]
Recent reviews (0)
All reviews listed in FlyBase were published before 2011