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General Information
Symbol
Dmel\Su(var)205
Species
D. melanogaster
Name
Suppressor of variegation 205
Annotation Symbol
CG8409
Feature Type
FlyBase ID
FBgn0003607
Gene Model Status
Stock Availability
Gene Snapshot
In progress.Contributions welcome.
Also Known As
HP1, Su(var)2-5, HP1a, heterochromatin protein 1, HP-1
Key Links
Genomic Location
Cytogenetic map
Sequence location
2L:8,209,626..8,211,122 [-]
Recombination map
2-30
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Protein Family (UniProt)
-
Summaries
Gene Group (FlyBase)
HETEROCHROMATIN PROTEIN 1 FAMILY -
Heterochromatin Protein 1 (HP1, Su(var)205) was first discovered in Drosophila as a dominant suppressor of position-effect variegation and a major component of heterochromatin. Members of the HP1 family are characterised by the presence of an N-terminal chromodomain and a C-terminal chromoshadow domain. In addition to heterochromatin packaging and silencing, HP1 proteins have diverse roles in the nucleus, including the regulation of euchromatic genes. (Adapted from FBrf0193304).
Protein Function (UniProtKB)
Structural component of heterochromatin, involved in gene repression and the modification of position-effect-variegation. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression.
(UniProt, P05205)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
Su(var)205
Encodes a nonhistone chromosomal protein, HP1, which by immunofluorescent staining of polytene chromosomes with a monoclonal antibody, is localized to α, β, and intercallary heterochromatin as well as chromosome 4 (James and Elgin, 1986, Mol. Cell. Biol. 6: 3862-72).
Summary (Interactive Fly)
chromodomain - Polycomb group - chromatin associated protein - required both for activation of heterochromatic genes and silencing of euchromatic genes
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\Su(var)205 or the JBrowse view of Dmel\Su(var)205 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.45
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0079635
992
206
FBtr0079636
1109
206
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0079251
23.2
206
4.73
FBpp0079252
23.2
206
4.73
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

206 aa isoforms: Su(var)205-PA, Su(var)205-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)
Homodimer; probably associates with Su(var)3-9. Interacts with Mcm10. Interacts (via chromoshadow domain) with piwi (via N-terminal region).
(UniProt, P05205)
Crossreferences
PDB - An information portal to biological macromolecular structures
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Su(var)205 using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Gene Ontology (42 terms)
Molecular Function (8 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from direct assay
inferred from physical interaction with FLYBASE:ADD1; FB:FBgn0026573
inferred from physical interaction with FLYBASE:HIPP1; FB:FBgn0037027
inferred from physical interaction with UniProtKB:Q95RV2
(assigned by UniProt )
inferred from physical interaction with FLYBASE:Su(var)3-7; FB:FBgn0003598
inferred from direct assay
inferred from direct assay
inferred from direct assay
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
non-traceable author statement
non-traceable author statement
Biological Process (19 terms)
Terms Based on Experimental Evidence (17 terms)
CV Term
Evidence
References
inferred from high throughput mutant phenotype
inferred from high throughput mutant phenotype
inferred from mutant phenotype
inferred from direct assay
inferred from mutant phenotype
inferred from direct assay
inferred from mutant phenotype
inferred from direct assay
(assigned by CACAO )
inferred from direct assay
inferred from genetic interaction with FLYBASE:egg; FB:FBgn0086908
inferred from direct assay
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
Cellular Component (15 terms)
Terms Based on Experimental Evidence (14 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
traceable author statement
non-traceable author statement
traceable author statement
non-traceable author statement
traceable author statement
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
organism

Comment: maternally deposited

northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Analysis ofchromosome spreads of polytene salivary chromosomes shows that the Su(var)205 (HP1) protein localizes predominately to known heterochromatic regions and regions that are transcriptionally repressed such as band 31 on Chromosome 2L.
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Su(var)205 in GBrowse 2
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
  • Stages(s) 1-3
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 20 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 67 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Su(var)205
Transgenic constructs containing regulatory region of Su(var)205
Deletions and Duplications ( 6 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
meiosis & nuclear chromosome | male
mitosis & chromosome, telomeric region
mitosis & nuclear chromosome (with Su(var)2054)
mitosis & nuclear chromosome (with Su(var)2055)
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (11)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
9 of 15
Yes
No
 
8 of 15
No
No
 
6 of 15
No
No
 
 
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (7)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
9 of 15
Yes
No
 
6 of 15
No
No
5 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (5)
9 of 13
Yes
No
7 of 13
No
Yes
7 of 13
No
No
1 of 13
No
Yes
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (4)
7 of 12
Yes
Yes
5 of 12
No
No
5 of 12
No
Yes
1 of 12
No
Yes
Danio rerio (Zebrafish) (6)
11 of 15
Yes
Yes
10 of 15
No
No
8 of 15
No
Yes
7 of 15
No
No
6 of 15
No
Yes
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (8)
12 of 15
Yes
Yes
5 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (1)
1 of 9
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (1)
1 of 15
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (2)
5 of 12
Yes
Yes
4 of 12
No
No
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG09190HKT )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150DRW )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Musca domestica
House fly
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Glossina morsitans
Tsetse fly
Glossina morsitans
Tsetse fly
Glossina morsitans
Tsetse fly
Glossina morsitans
Tsetse fly
Glossina morsitans
Tsetse fly
Glossina morsitans
Tsetse fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Mayetiola destructor
Hessian fly
Mayetiola destructor
Hessian fly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Aedes aegypti
Yellow fever mosquito
Aedes aegypti
Yellow fever mosquito
Anopheles gambiae
Malaria mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Culex quinquefasciatus
Southern house mosquito
Culex quinquefasciatus
Southern house mosquito
Culex quinquefasciatus
Southern house mosquito
Culex quinquefasciatus
Southern house mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0K00 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Dendroctonus ponderosae
Mountain pine beetle
Dendroctonus ponderosae
Mountain pine beetle
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Tribolium castaneum
Red flour beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Acyrthosiphon pisum
Pea aphid
Acyrthosiphon pisum
Pea aphid
Acyrthosiphon pisum
Pea aphid
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Zootermopsis nevadensis
Nevada dampwood termite
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0K5Y )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0RBS )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Ciona intestinalis
Vase tunicate
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (7)
6 of 10
5 of 10
5 of 10
4 of 10
3 of 10
2 of 10
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 2 )
    Allele
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Dmel gene
    Ortholog showing functional complementation
    Supporting References
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser

    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    RNA-protein
    Physical Interaction
    Assay
    References
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement

    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    suppressible
    External Data
    Subunit Structure (UniProtKB)
    Homodimer; probably associates with Su(var)3-9. Interacts with Mcm10. Interacts (via chromoshadow domain) with piwi (via N-terminal region).
    (UniProt, P05205 )
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Gene Group - Pathway Membership (FlyBase)
    External Data
    Linkouts
    SignaLink - A signaling pathway resource with multi-layered regulatory networks.
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    2L
    Recombination map
    2-30
    Cytogenetic map
    Sequence location
    2L:8,209,626..8,211,122 [-]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    28F2-28F3
    Limits computationally determined from genome sequence between P{lacW}l(2)k16919k16919&P{lacW}Bsgk09030 and P{lacW}Btk29Ak00206&P{EP}Btk29AEP715
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    29A-29A
    (determined by in situ hybridisation)
    Location based on deficiency mapping.
    Experimentally Determined Recombination Data
    Location
    2-28.9
    2-31.1 +/- 3.1
    2-24.7 +/- 1.3
    2-28.9 +/- 2.0
    2-31.1
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (20)
    Genomic Clones (20)
    cDNA Clones (60)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequences
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Antibody Information
    Laboratory Generated Antibodies
    Commercially Available Antibodies
     
    Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
    Other Information
    Relationship to Other Genes
    Source for database identify of
    Source for database merge of
    Additional comments
    Other Comments
    DNA-protein interactions: genome-wide binding profile assayed for Su(var)205 protein in Kc167 cells; see Chromatin_types_NKI collection report. Individual protein-binding experiments listed under "Samples" at GEO_GSE22069 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE22069).
    Expression is enriched in embryonic gonads.
    The Su(var)205 protein modulates chromosomal integrity, histone modifications and transcription in a sex-specific manner.
    The binding of Su(var)205 protein to many, but not all, target loci is dependent on Su(var)3-9.
    Methyl-K9 His3 protein and Su(var)205 protein co-localise to the heterochromatic region of polytene chromosomes.
    Su(var)205 may facilitate the coalescence of dispersed middle repetitive sequences, and organise the heterochromatic structure responsible for the variegated silencing of nearby euchromatic genes.
    Su(var)205 is required for normal transcriptional activation of heterochromatic genes.
    A consensus pentapeptide is sufficient for specific interaction with the Su(var)205 chromo shadow domain. Su(var)205 dimerisation occurs via pentapeptide binding.
    Mutations in Su(var)205 suppress telomeric Position Effect Variegation (PEV) on the fourth chromosome, but not the second and third chromosomes.
    The Su(var)205 product, HP1, targets the chromatin of transposon insertions and binds more densely at a site with repeated sequences susceptible to heterochromatin formation. Sufficient density of Su(var)205 protein association is a necessary step in heterochromatin formation and gene silencing.
    Actr13E colocalises with Su(var)205 in the centric heterochromatin throughout prepupal development and the two proteins undergo a series of changes in nuclear distribution that coincide with major shifts in nuclear functions.
    Naturally occurring regulatory P-elements inserted at the telomere of the X chromosome have been isolated in a genomic context devoid of other P-elements. One or two copies of autonomous P-elements at this site (1A) are sufficient to elicit a strong P repression in the germline. Regulatory properties of the P-elements at 1A are strongly impaired by mutation of Su(var)205.
    The regulatory properties of P-elements at 1A are affected by mutants at Su(var)205.
    Su(var)205 protein contains a second chromo domain-like motif, the 'chromo shadow domain', in the C-terminal part of the protein.
    Studies of the embryonic lethality of mutants demonstrates that in addition to its effect on position-effect variegation, Su(var)205 is also required for normal nuclear morphology and mitosis.
    The intracellular localisation of Su(var)205 in the diploid nuclei of embryos before and after developmental changes that occur between cycles 10 and 14 is studied.
    Point mutations in the chromo domain of Su(var)205 abolish its ability to promote homeotic gene silencing. The chromo domain has chromosome binding activity. Pc also has a chromo domain, a chimeric Su(var)205-Pc protein (the chromo domain of Pc in the context of Su(var)205) causes mislocalisation of Su(var)205 to Pc binding sites and expression in transgenic flies promotes heterochromatin mediated gene silencing. Results support the view that the chromo domain homology reflects a common mechanistic basis for homeotic and heterochromatic silencing.
    Su(var)205 is multiply phosphorylated in tissues, predominantly at Ser and Thr residues. Maternally synthesised Su(var)205 protein is under phosphorylated. At 1.5-2 hours of development, when cytologically visible heterochromatin appears, the more phosphorylated Su(var)205 isoforms appear. Results are consistent with a role for phosphorylation of Su(var)205 in the assembly and maintenance of heterochromatin.
    The presence of Su(var)205 does not have any discernible effect on wzm, wzl, wzvl, wzh or wcres, this was not checked in X/0 males.
    Heterochromatin-associated Su(var)205 gene product appears in euchromatic chromosomal regions that are inactivated as a result of position-effect variegation.
    Analysis of the subcellular localisation of Ecol\lacZ-Su(var)205 fusion proteins shows that amino acids 152-206 form the nuclear localisation domain and amino acids 95 to 206 form the heterochromatin binding domain of the Su(var)205 protein.
    Su(var)205 homologue has been cloned from D.virilis : a high degree of conservation in N- and C-terminal domains of the encoded DNA-binding protein "HP1" suggests that these domains could interact with other macromolecules in the formation of the condensed structure of heterochromatin.
    Su(var)205 gene product is an essential protein that functions as a part of an epigenetic mechanism capable of generating and maintaining an inactive chromatin structure.
    Alleles show additive effects with mod alleles on suppression of In(1)wm4 position effect variegation.
    Su(var)205 protein, detected by the C1A9 antibody in polytene chromosomes, is preferentially located in the beta-heterochromatin, the basal regions of the polytene chromosome arms and throughout chromosome 4.
    Triplo-dependent enhancer of variegation.
    The variegation enhancer phenotype is due to increase in gene dosage: independently derived duplications of Su(var)205 act as enhancers and reversion of the dominant enhancer phenotype corresponds with the loss of the duplication.
    triplo-enhancer; duplications for the locus cause enhancement of variegation (Tartof, Bishop, Jones, Hobbs and Locke, 1989).
    Encodes a nonhistone chromosomal protein, which by immunofluorescent staining of polytene chromosomes with a monoclonal antibody, is localized to α, β, and intercalary heterochromatin as well as chromosome 4 (FBrf0045031).
    Origin and Etymology
    Discoverer
    Etymology
    Identification
    External Crossreferences and Linkouts ( 55 )
    Sequence Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
    Other crossreferences
    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    Flygut - An atlas of the Drosophila adult midgut
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
    KEGG Genes - Molecular building blocks of life in the genomic space.
    modMine - A data warehouse for the modENCODE project
    PDB - An information portal to biological macromolecular structures
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    SignaLink - A signaling pathway resource with multi-layered regulatory networks.
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DPiM - Drosophila Protein interaction map
    DroID - A comprehensive database of gene and protein interactions.
    DRSC - Results frm RNAi screens
    Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    FlyMine - An integrated database for Drosophila genomics
    Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    Synonyms and Secondary IDs (57)
    Reported As
    Symbol Synonym
    E(var)29A
    HP1
    (Radion et al., 2019, Lee et al., 2018, Singh et al., 2018, Specchia et al., 2017, Cipressa et al., 2016, Derkacheva et al., 2016, Jiang et al., 2016, Kavi et al., 2016, L Black et al., 2016, Pindyurin and van Steensel, 2016.7.25, Dietz et al., 2015, Gandhi et al., 2015, Kavi et al., 2015, Meller et al., 2015, Pan et al., 2015, Pokholkova et al., 2015, Vedelek et al., 2015, Vernì and Cenci, 2015, Azzaz et al., 2014, Barton et al., 2014, Chen et al., 2014, Figueiredo et al., 2014, López-Falcón et al., 2014, Marr et al., 2014, Nordman et al., 2014, Oliveira et al., 2014, Ost et al., 2014, Xu et al., 2014, Zhang et al., 2014, Herzog et al., 2013, Le Thomas et al., 2013, Levine and Malik, 2013, Lu et al., 2013, Rohrbaugh et al., 2013, Salzler et al., 2013, Savva et al., 2013, Silver-Morse and Li, 2013, van Bemmel et al., 2013, Wood and Helfand, 2013, Anand and Kai, 2012, Bateman et al., 2012, Dubruille et al., 2012, Ito et al., 2012, Lakhotia et al., 2012, Larson et al., 2012, Loh et al., 2012, Maheshwari and Barbash, 2012, Maheshwari and Barbash, 2012, Singh and Lakhotia, 2012, Stern et al., 2012, Tan et al., 2012, Abramov et al., 2011, Brideau and Barbash, 2011, Burgio et al., 2011, Dufourt et al., 2011, Gibert and Karch, 2011, Klenov et al., 2011, Lee et al., 2011, Li et al., 2011, Olszak et al., 2011, Pane et al., 2011, Raffa et al., 2011, Seong et al., 2011, Shpiz et al., 2011, Yan et al., 2011, Apger et al., 2010, Biteau et al., 2010, Boeke et al., 2010, Bulchand et al., 2010, Chioda et al., 2010, Dialynas et al., 2010, Dubruille et al., 2010, Filion et al., 2010, Gao et al., 2010, Gurudatta et al., 2010, Hofmann et al., 2010, Huang et al., 2010, Kim et al., 2010, Lipsick, 2010.4.22, Moshkovich and Lei, 2010, Raffa et al., 2010, Reo et al., 2010, Schwaiger et al., 2010, Todeschini et al., 2010, van Steensel et al., 2010, Brower-Toland et al., 2009, Fagegaltier et al., 2009, Gracheva et al., 2009, Hines et al., 2009, Joppich et al., 2009, Kavi and Birchler, 2009, Klapholz et al., 2009, Koch et al., 2009, Komonyi et al., 2009, Lee et al., 2009, Lu et al., 2009, Nie et al., 2009, Raffa et al., 2009, Salvany et al., 2009, Schneiderman et al., 2009, Shevelyov et al., 2009, Vogel et al., 2009, Zhao et al., 2009, Brideau and Barbash, 2008, Chen et al., 2008, Cryderman et al., 2008, de Wit et al., 2008, Fanti et al., 2008, Frydrychova et al., 2008, Gause et al., 2008, Koch et al., 2008, Lloret-Llinares et al., 2008, Nisha et al., 2008, Pindyurin et al., 2008, Pinto et al., 2008, Remaud et al., 2008, Riddle et al., 2008, Scaria et al., 2008, Schwendemann et al., 2008, Sharakhov et al., 2008, Shi et al., 2008, Srinivasan et al., 2008, Sweeney et al., 2008, Wen et al., 2008, Yoon et al., 2008, Zhang et al., 2008, Bai et al., 2007, Brideau et al., 2007, Budde, 2007, Christensen et al., 2007, Cryderman et al., 2007, Cummings et al., 2007, Demakova et al., 2007, Deng et al., 2007, de Wit et al., 2007, Dronamraju and Mason, 2007, Goldberg et al., 2007, Greil et al., 2007, Grewal and Elgin, 2007, Johansson et al., 2007, Johansson et al., 2007, Josse et al., 2007, Klenov et al., 2007, Lee et al., 2007, Li et al., 2007, Minervini et al., 2007, Morris and Moazed, 2007, Nakayama et al., 2007, Nisha and Csink, 2007, Oikemus et al., 2007, Pathak et al., 2007, Peng and Karpen, 2007, Pindyurin et al., 2007, Ronsseray et al., 2007, Ronsseray et al., 2007, Sasai et al., 2007, Seum et al., 2007, Shi et al., 2007, Straub and Becker, 2007, Tzeng et al., 2007, Wagner et al., 2007, Yin and Lin, 2007, Zaratiegui, 2007, Zhimulev et al., 2007, Barbash et al., 2006, Birchler et al., 2006, Blattes et al., 2006, Brandt, 2006, Brandt et al., 2006, Brideau et al., 2006, Cavalli, 2006, Ciapponi et al., 2006, Deng et al., 2006, Deshpande et al., 2006, Eissenberg and Shilatifard, 2006, Haynes et al., 2006, Hediger and Gasser, 2006, Koryakov et al., 2006, Lomberk et al., 2006, Melcer and Gruenbaum, 2006, Oikemus et al., 2006, Orian, 2006, Peng and Karpen, 2006, Pickersgill et al., 2006, Shaffer et al., 2006, Shi et al., 2006, Stephens et al., 2006, Tolhuis et al., 2006, Varga-Weisz and Becker, 2006, Yasuhara and Wakimoto, 2006, Zhang et al., 2006, Adu-Wusu et al., 2005, Andreyeva et al., 2005, Badugu et al., 2005, Bi et al., 2005, Birchler et al., 2005, Carre et al., 2005, Cenci et al., 2005, Craig, 2005, Cryderman et al., 2005, de la Cruz et al., 2005, De Lucia et al., 2005, de Wit et al., 2005, Gvozdev et al., 2005, Hines et al., 2005, Ivanovska et al., 2005, Kamakaka and Biggins, 2005, Kavi et al., 2005, Liu et al., 2005, Louis and Vershinin, 2005, Nikolenko et al., 2005, Peng et al., 2005, Raffa et al., 2005, Schulze et al., 2005, Spierer et al., 2005, Stephens et al., 2005, Swaminathan et al., 2005, van Steensel et al., 2005, Vermaak et al., 2005, Wallace and Orr-Weaver, 2005, Wang et al., 2005, Ahmad, 2004, Brehm et al., 2004, Cao and Zhang, 2004, Ciapponi et al., 2004, Danzer and Wallrath, 2004, Delattre et al., 2004, Ebert et al., 2004, Huertas et al., 2004, Kosak and Groudine, 2004, Levine et al., 2004, Lippman and Martienssen, 2004, Lund and van Lohuizen, 2004, Oikemus et al., 2004, Pal-Bhadra et al., 2004, Perrini et al., 2004, Purdy and Su, 2004, Ronsseray et al., 2004, Sanchez-Elsner and Sauer, 2004, Schotta et al., 2004, Shaffer et al., 2004, Sun et al., 2004, Sural and Kuroda, 2004, Workman and Abmayr, 2004, Anonymous, 2003, Belyaeva et al., 2003, Berg et al., 2003, Biessmann and Mason, 2003, Boivin et al., 2003, Cenci et al., 2003, Cenci et al., 2003, Cortes et al., 2003, Cryderman et al., 2003, Danzer et al., 2003, Ebert et al., 2003, Fahrner and Baylin, 2003, Fanti et al., 2003, Fischle et al., 2003, Greil et al., 2003, Grewal and Moazed, 2003, Jaskelioff and Peterson, 2003, Josse et al., 2003, Kellum, 2003, Korge et al., 2003, Li et al., 2003, Li et al., 2003, McNairn and Gilbert, 2003, Min et al., 2003, Orlando, 2003, Piacentini et al., 2003, Salvaing et al., 2003, Shareef et al., 2003, Simms et al., 2003, Stephens et al., 2003, Sun et al., 2003, Zhimulev and Belyaeva, 2003, Badugu and Kellum, 2002, Cowell et al., 2002, Delattre et al., 2002, Dillon and Festenstein, 2002, Fourel et al., 2002, Gerbi and Bielinsky, 2002, Grade et al., 2002, Jacobs and Khorasanizadeh, 2002, Jaquet et al., 2002, Li et al., 2002, Li et al., 2002, Lynn et al., 2002, Neely and Workman, 2002, Richards and Elgin, 2002, Savitsky et al., 2002, Schotta et al., 2002, Shaffer, 2002.11.14, Shaffer et al., 2002, Siriaco et al., 2002, Ahmad and Henikoff, 2001, Barlow et al., 2001, Blower and Karpen, 2001, Danzer et al., 2001, Eissenberg, 2001, Eissenberg et al., 2001, Elgin et al., 2001, Hari et al., 2001, Hwang et al., 2001, Hwang et al., 2001, Jacobs et al., 2001, Jenuwein and Allis, 2001, Li et al., 2001, Linder et al., 2001, Ma et al., 2001, Martienssen, 2001, Moazed, 2001, Sanjuan and Marin, 2001, Seum et al., 2001, Seum et al., 2001, Shareef et al., 2001, Shareef et al., 2001, Van Steensel et al., 2001, van Steensel et al., 2001, van Steensel et al., 2001, Volpe et al., 2001, Wallrath et al., 2001, Zhang and Reinberg, 2001, Zhao et al., 2001, Anonymous, 2000, Birchler et al., 2000, Cenci et al., 2000, Cryderman et al., 2000, Delattre et al., 2000, Eissenberg and Elgin, 2000, Eissenberg and Hilliker, 2000, Gebuhr et al., 2000, Li et al., 2000, Naumova et al., 2000, Seum et al., 2000, Shaffer et al., 2000, Smothers and Henikoff, 2000, van Steensel and Henikoff, 2000, van Steensel and Henikoff, 2000, Wallrath, 2000, Wallrath et al., 2000, Zhao et al., 2000, Aasland, 1999, Aasland, 1999, Bernat et al., 1999, Cortes et al., 1999, Cryderman et al., 1999, Cryderman et al., 1999, Cryderman et al., 1999, Delattre et al., 1999, Dobie et al., 1999, Elgin et al., 1999, Kornberg and Lorch, 1999, Schotta et al., 1999, Siriaco et al., 1999, Sun et al., 1999, Zhao and Eissenberg, 1999, Anonymous, 1998, Cavalli and Paro, 1998, Elgin et al., 1998, Fanti et al., 1998, Fanti et al., 1998, Gregory and Horz, 1998, Huang et al., 1998, Lu and Eissenberg, 1998, Nelson et al., 1998, Platero et al., 1998, Singh and Huskisson, 1998, Sun et al., 1998, Wallrath, 1998, Wallrath et al., 1998, Belyaeva et al., 1997, Cleard et al., 1997, Elgin et al., 1997, Frankel et al., 1997, Goldman, 1997, Hilfiker et al., 1997, Huang and Kellum, 1997, Nelson and Tomkiel, 1997, Pak et al., 1997, Pirrotta, 1997, Platero et al., 1997, Wakimoto, 1997, Wilkins and Lis, 1997, Zuckerkandl, 1997, Balasov and Makunin, 1996, Huang and Kellum, 1996, Platero et al., 1996, Svaren and Hoerz, 1996, Aasland and Stewart, 1995, Kellum and Alberts, 1995, Kellum et al., 1995, Koonin et al., 1995, Ngan et al., 1995, Platero et al., 1995, Becker, 1994, Carlson and Laurent, 1994, Eissenberg et al., 1994, Elgin et al., 1994, Kellum and Alberts, 1994, Belyaeva et al., 1993, Eissenberg and Hartnett, 1993, Kellum and Alberts, 1993, Powers and Eissenberg, 1993, Saunders et al., 1993, Shaffer et al., 1993, Epstein et al., 1992, Singh et al., 1991, Elgin, 1990, James et al., 1989)
    HP1a
    (Gervais et al., 2019, Lee et al., 2019, Park et al., 2019, Seller et al., 2019, Sidorenko et al., 2019, Yang et al., 2019, Akulenko et al., 2018, Caridi et al., 2018, Clémot et al., 2018, Jankovics et al., 2018, Penke et al., 2018, Rosin et al., 2018, Šatović et al., 2018, Seller and O'Farrell, 2018, Warecki and Sullivan, 2018, Amaral et al., 2017, Caridi et al., 2017, Chavez et al., 2017, Colmenares et al., 2017, Gerland et al., 2017, Hyun, 2017, Marshall and Brand, 2017, Roelens et al., 2017, Strom et al., 2017, Tsurumi et al., 2017, Vo et al., 2017, Yamada et al., 2017, Yang and Xi, 2017, Bayona-Feliu et al., 2016, Boija and Mannervik, 2015, Eberle et al., 2015, Liu and Zhang, 2015, Ryu et al., 2015, Sienski et al., 2015, Yu et al., 2015, Alekseyenko et al., 2014, Alekseyenko et al., 2014, Comoglio and Paro, 2014, Eissenberg and Elgin, 2014, Messina et al., 2014, Pascual-Garcia et al., 2014, Ross et al., 2014, Satyaki et al., 2014, Crona et al., 2013, Huang et al., 2013, Lundberg et al., 2013, Ohtani et al., 2013, Thomae et al., 2013, Yamamoto and Koganezawa, 2013, Dialynas et al., 2012, Dubruille et al., 2012, Figueiredo et al., 2012, Ito et al., 2012, Joyce et al., 2012, Lin et al., 2012, Riddle et al., 2012, Sakoparnig et al., 2012, Salvany et al., 2012, Sentmanat and Elgin, 2012, Cryderman et al., 2011, Demakov et al., 2011, Kharchenko et al., 2011, Kwon and Workman, 2011, Kwon and Workman, 2011, Li et al., 2011, Mendez et al., 2011, Pek and Kai, 2011, Wang and Elgin, 2011, Yin et al., 2011, Zhang et al., 2011, Chioda et al., 2010, Emelyanov et al., 2010, Kwon et al., 2010, modENCODE Consortium et al., 2010, Abel et al., 2009, Lau et al., 2009, Pek et al., 2009, Piacentini et al., 2009, Schulze et al., 2009, Doheny et al., 2008, Lin et al., 2008, Brower-Toland et al., 2007, Przewloka et al., 2007, Moorman et al., 2006, Moorman et al., 2006, Talbert and Henikoff, 2006, Yasuhara and Wakimoto, 2006, Liu et al., 2005, Osouda et al., 2005, Badugu et al., 2003, Smothers and Henikoff, 2001)
    Su(Var)205
    Su(var)2-5
    (Chang et al., 2019, Glenn and Geyer, 2019, Park et al., 2019, Derkacheva et al., 2016, Hong and Choi, 2016, Timms et al., 2016, Crona et al., 2013, Elgin and Reuter, 2013, Silva-Sousa and Casacuberta, 2013, Vasanthi et al., 2013, Abramov et al., 2011, Batlle et al., 2011, Cryderman et al., 2011, Wang et al., 2011, Yan et al., 2011, Emelyanov et al., 2010, Hofmann et al., 2010, Kwon et al., 2010, Moshkovich and Lei, 2010, Prabhakaran and Kelley, 2010, Todeschini et al., 2010, Hines et al., 2009, Joppich et al., 2009, Lu et al., 2009, Phalke et al., 2009, Piacentini et al., 2009, Schulze et al., 2009, Doheny et al., 2008, Gause et al., 2008, Lin et al., 2008, Pindyurin et al., 2008, Riddle et al., 2008, Schwendemann et al., 2008, Yang et al., 2008, Andreyeva et al., 2007, Brower-Toland et al., 2007, Demakova et al., 2007, Deng et al., 2007, Haigh and Lloyd, 2007, Rudolph et al., 2007, Shpiz et al., 2007, Eissenberg and Shilatifard, 2006, Koryakov et al., 2006, Lomberk et al., 2006, Cenci et al., 2005, Cryderman et al., 2005, Dimitri et al., 2005, Lam et al., 2005, Schulze et al., 2005, Spierer et al., 2005, Swaminathan et al., 2005, Bazin et al., 2004, Cenci et al., 2004, Ebert et al., 2004, Norwood et al., 2004, Segal et al., 2004, Sun et al., 2004, Belyaeva et al., 2003, Cenci et al., 2003, Cenci et al., 2003, Erhardt et al., 2003, Fahrner and Baylin, 2003, Fanti et al., 2003, Kelley and Kuroda, 2003, Li et al., 2003, Perrod and Gasser, 2003, Yoo et al., 2003, Zhimulev and Belyaeva, 2003, Balasov, 2002, Bernard and Allshire, 2002, Blower and Karpen, 2002, Cenci et al., 2002, Delattre et al., 2002, Donaldson et al., 2002, Georgiev et al., 2002, Grewal and Elgin, 2002, Joanis and Lloyd, 2002, Li et al., 2002, Richards and Elgin, 2002, Savitsky et al., 2002, Schotta et al., 2002, Westphal and Reuter, 2002, Blower and Karpen, 2001, Choo, 2001, Gasser, 2001, Hwang et al., 2001, Jenuwein and Allis, 2001, Ma et al., 2001, Seum et al., 2001, Sun et al., 2001, Yoo et al., 2001, Balasov et al., 2000, Balasov et al., 2000, Eissenberg and Elgin, 2000, Eissenberg and Hilliker, 2000, Gebuhr et al., 2000, Gvozdev et al., 2000, Lu et al., 2000, McKee et al., 2000, Naumova et al., 2000, Seum et al., 2000, Sun et al., 2000, Cryderman et al., 1999, Cryderman et al., 1999, Delattre et al., 1999, Sun et al., 1999, Cavalli and Paro, 1998, Cryderman et al., 1998, Fanti et al., 1998, Sass and Henikoff, 1998, Cleard and Spierer, 1997, Cleard et al., 1997, Dorn et al., 1993, Eissenberg et al., 1990)
    Su(var)2-501
    Su(var)205
    (Martins et al., 2019, Shimaji et al., 2019, Shokri et al., 2019, Bischof et al., 2018, Hughes et al., 2018, Jankovics et al., 2018, Levis, 2018.8.30, Markmiller et al., 2018, Masuko et al., 2018, Warecki and Sullivan, 2018, Amaral et al., 2017, Caridi et al., 2017, Kurzhals et al., 2017, Marie et al., 2017, Neuert et al., 2017, Roelens et al., 2017, Teixeira et al., 2017, Transgenic RNAi Project members, 2017-, Cipressa et al., 2016, Clandinin and Owens, 2016-, Guida et al., 2016, Jiang et al., 2016, Dietz et al., 2015, Dubruille and Loppin, 2015, Kim et al., 2015, Nikalayevich and Ohkura, 2015, Sienski et al., 2015, Aldrich and Maggert, 2014, Frost et al., 2014, Gonzalez et al., 2014, Kim and Choe, 2014, Kuang et al., 2014, Wang et al., 2014, Yan et al., 2014, Czech et al., 2013, Kwon et al., 2013, Mason, 2013.1.25, Moshkin et al., 2013, Raffa et al., 2013, Rohrbaugh et al., 2013, Sentmanat et al., 2013, Silver-Morse and Li, 2013, Vaque et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Larson et al., 2012, Riddle et al., 2012, Salvany et al., 2012, Sentmanat and Elgin, 2012, Simmons et al., 2012, Dufourt et al., 2011, Friedman et al., 2011, Gieger et al., 2011, Kurzhals et al., 2011, Li et al., 2011, Neumüller et al., 2011, Raffa et al., 2011, Reis et al., 2011, Yan et al., 2011, Chioda et al., 2010, Dubruille et al., 2010, Gan et al., 2010, Gou et al., 2010, Gurudatta et al., 2010, Kallappagoudar et al., 2010, Raffa et al., 2010, Simmons et al., 2010, Todeschini et al., 2010, Anderson et al., 2009, Belinco et al., 2009, Chen et al., 2008, Frydrychova et al., 2008, Kent, 2008, Musarò et al., 2008, Nisha et al., 2008, Ronsseray et al., 2008, Shi et al., 2008, Haigh and Lloyd, 2007, Josse et al., 2007, Prasad and Mason, 2007, Ronsseray et al., 2007, Xing et al., 2007, Minakhina and Steward, 2006, Shi et al., 2006, Shigenobu et al., 2006, Yasuhara and Wakimoto, 2006, Andreyeva et al., 2005, Bi et al., 2005, Kalmykova et al., 2005, Liu et al., 2005, Le et al., 2004, Gim et al., 2001, Linder et al., 2001)
    Su(var)29A
    Sur(var)205
    Name Synonyms
    C1A9-nuclear-antigen
    Heterochromatic Protein 1
    Heterochromatic Protein 1a
    Heterochromatin Protein 1A
    Heterochromatin Protein 1a
    Heterochromatin protein 1A
    Heterochromatin protein-1
    Histone Protein 1
    Su(var)205
    heterochromatic protein
    heterochromatin factor 1
    heterochromatin protein-1
    heterochromatin-binding protein
    suppressor of variegated 205
    suppressor of variegation 205
    Secondary FlyBase IDs
      Datasets (4)
      Study focus (4)
      Experimental Role
      Project
      Project Type
      Title
      • transgene_used
      Protein profiling reveals five principal chromatin types in Drosophila cells.
      • RNAi_target
      Genome-wide localization of chromosomal proteins in cell lines by ChIP-chip and ChIP-Seq.
      • allele_used
      Genome-wide localization of chromosomal proteins in fly tissues by ChIP-chip and ChIP-Seq.
      • allele_used
      Genome-wide localization of histones and their modifications in fly tissues by ChIP-chip and ChIP-Seq.
      References (827)