A Database of Drosophila Genes & Genomes

FB2012_01, released January 20th, 2012
 

Gene Dmel\Su(var)205

General Information
SymbolDmel\Su(var)205SpeciesD. melanogaster
NameSuppressor of variegation 205Annotation symbolCG8409
Feature typeprotein_coding_geneFlyBase IDFBgn0003607
Gene Model StatusCurrent Stock availability 14 publicly available
Also Known AsHP1, Su(var)2-5, HP1A, HP-1, Suvar(2)5, Su(var)205, HP1α, SuVar205
Genomic Location
Chromosome (arm)2LRecombination map2-31.1
Cytogenetic map28F2-28F3Sequence location2L:8,209,626..8,211,133 [-]

Genomic Maps

GBrowse View Help
modENCODE GBrowse
detailed view
hide Summary Information
Automatically generated summary

See sections below for more information
The gene Suppressor of variegation 205 is referred to in FlyBase by the symbol Dmel\Su(var)205 (CG8409, FBgn0003607). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding; satellite DNA binding; rDNA binding; chromatin binding. There is experimental evidence for 11 unique biological process terms, many of which group under: biological regulation; cellular component organization or biogenesis; regulation of cellular macromolecule biosynthetic process; regulation of metabolic process; negative regulation of gene expression, epigenetic; negative regulation of nitrogen compound metabolic process; chromatin organization; telomere maintenance; regulation of biological process; anatomical structure development. 81 alleles are reported. The phenotypes of these alleles are annotated with: eye disc; eye; wing disc; chromosome, telomeric region; neuroblast; mitotic cell cycle; polytene chromosome; imaginal disc; embryonic/larval optic lobe; melanotic mass. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Chromo domain; Chromo domain subgroup; Chromo domain, conserved site; Chromo domain-like; Chromo domain/shadow; Chromo shadow; Chromo shadow, subgroup. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages, during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, larval hindgut, larval Malpighian tubules, larval salivary gland, larval trachea, adult ovary, adult male accessory gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult crop, larval/adult midgut, adult hindgut, adult Malpighian tubules, adult heart, larval/adult fat body, adult salivary gland, adult spermathecae, adult testis, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1640689_a_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of Su(var)205. Gene sequence location is 2L:8209626..8211133.

External Summaries

hide Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage
Su(var)205
Encodes a nonhistone chromosomal protein, HP1, which by immunofluorescent staining of polytene chromosomes with a monoclonal antibody, is localized to α, β, and intercallary heterochromatin as well as chromosome 4 (James and Elgin, 1986, Mol. Cell. Biol. 6: 3862-72).
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Description
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This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).
What does this section not display?
This section does not currently display links that were removed or gene model changes.
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atom feed
FB2011_10
References
Dronamraju and Mason, 2011, PLoS ONE 6(9): e25439
Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593
FB2012_01
References
Chiolo et al., 2011, Cell 144(5): 732--744
Riddle et al., 2011, Genome Res. 21(2): 147--163
Sequence features
BKN30828
HFA03446
Controlled Vocabulary Terms
protein binding
All updates Click here to see a list of all updates to this record from FB2010_08 and on.
hide Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
28F2-28F3  
Limits computationally determined from genome sequence between P{lacW}l(2)k16919k16919&P{lacW}Bsgk09030 and P{lacW}Btk29Ak00206&P{EP}Btk29AEP715  
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
29A-29A  
(determined by in situ hybridisation)  
(Eissenberg et al., 1990)
29A-29A  
(determined by in situ hybridisation)  
(James and Elgin, 1986)
28F2-29A1  
Location based on deficiency mapping.  
(Wustmann et al., 1989)
Experimentally Determined Recombination Data
Location
2-31.1
 
2-28.9 +/- 2.0
(Sinclair et al., 1983)
2-24.7 +/- 1.3
(Locke et al., 1988)
2-31.1 +/- 3.1
(Wustmann et al., 1989)
2-28.9
(Judd, 1995)
Left of (cM)
Right of (cM)
(Bushey and Locke, 2004)
Notes
hide Gene Model & Products
Please see the GBrowse view of Dmel\Su(var)205 for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
detailed view FBtr0079589 FBtr0079636 FBtr0079635 FBtr0079590 FBtr0079633 FBtr0079634 FBpp0079210 FBpp0079252 FBpp0079251 FBpp0079211 FBpp0079249 FBpp0079250 FBti0041790 FBti0048022 FBti0045982 FBti0115946 FBti0124419 FBti0041583 FBti0124651 FBti0115146
Comments on Gene Model
hide Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Associated CDS (aa)
Su(var)205-RA
FBtr0079635
 NM_057407
  1003
  206
Su(var)205-RB
FBtr0079636
 NM_164799
  907
  206
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
hide Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
Su(var)205-PA  
FBpp0079251  
23.2  
206  
4.73  
  NP_476755
  AAF52618
Su(var)205-PB  
FBpp0079252  
23.2  
206  
4.73  
  NP_723361
  AAN11156
Additional Polypeptide Data & Comments
Reported size (kDa)
206 (aa)
(Eissenberg et al., 1990)
Comments
External Data
Linkouts
Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
•
Chromo domain subgroup (IPR017984)
Chromo shadow, subgroup (IPR018125)
Chromo domain/shadow (IPR000953)
Chromo shadow (IPR008251)
Chromo domain-like (IPR016197)
Chromo domain, conserved site (IPR023779)
Chromo domain (IPR023780)
PDB - Protein Data Bank. An information portal to biological macromolecular structures
•
hide Sequences Consistent with the Gene Model
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
A70078
CAB42564
 
AA391214
 
AA439614
 
AA940807
 
AA951509
 
AE014134
AAF52618
 
AE014134
AAN11156
 
AC007696
 
AI297947
 
AI532642
 
AW942127
 
AY061119
AAL28667
 
AY231653
 
BE662174
 
BI165314
 
BI168565
 
BI173229
 
BI173965
 
BI212791
 
BI216937
 
BI228115
 
BI231006
 
BI231499
 
BI235067
 
BI239915
 
BI356087
 
BI356696
 
BI363982
 
BI365537
 
BI483790
 
BI484043
 
BI487140
 
BI569791
 
BI569819
 
BI570142
 
BI577188
 
BI605215
 
BI641418
 
BP542689
 
BP543285
 
BP543286
 
BP546295
 
BP547006
 
BQ103471
 
CO154693
 
CO181452
 
CO194944
 
CO266700
 
CO282921
 
CO285702
 
CO288177
 
CO292774
 
CO335549
 
CO336596
 
CZ471016
 
EC060287
 
EC063940
 
EC086603
 
EC089616
 
EC222546
 
EC224990
 
EC227758
 
EC230384
 
EC242031
 
EC259544
 
EC261004
 
EC261461
 
EV588835
 
EV597449
 
M14131
AAA28402
 
M57574
AAA28620
 
S78304
 
 
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
hide Mapped Features
Mapped Features have been reorganized, please see this article for details.
Additional mapped features and mutations can be found on GBrowse or related reports.
Type
Symbol & Location
Additional Notes
References
hide External Data
Linkouts
Crossreferences
hide Expression Data
hideTranscript Expression
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage  
 
(Eissenberg et al., 1990)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
hidePolypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
larval stage  
embryonic/larval salivary gland  
• heterochromatin
(Cowell et al., 2002)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
day 7 of adulthood -- day 49 of adulthood  
adult heart  
(Cammarato et al., 2011)
Additional Descriptive Data
Analysis ofchromosome spreads of polytene salivary chromosomes shows that the Su(var)205 (HP1) protein localizes predominately to known heterochromatic regions and regions that are transcriptionally repressed such as band 31 on Chromosome 2L.
(Cowell et al., 2002)
Marker for
Subcellular Localization
CV Term
Notes
hide High-Throughput Expression Data
or
Untitled Document detailed view CG8419-RA Su(var)205-RB Su(var)205-RA Ssb-c31a-RA CG8372-RA CG8372-RB
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.

modENCODE Temporal Expression Data for FBgn0003607


   Styles
Linear
Logarithmic
Heatmap
   Scales
max expr for FBgn0003607
Very low expression bin max
Moderate expression bin max
High expression bin max
Extremely high expression bin max

Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages, during early pupal stages.
[download data (TSV)]

Guide to modENCODE expression level colors
 
 No expression (0 - 0)
 
 Extremely low expression (1 - 10)
 
 Very low expression (11 - 100)
 
 Low expression (101 - 400)
 
 Moderate expression (401 - 1400)
 
 Moderately high expression (1401 - 4000)
 
 High expression (4001 - 10000)
 
 Very high expression (10001 - 100000)
 
 Extremely high expression (100001 - 2000000)

Linear, scaled to maximum FBgn0003607 expression level
Developmental Stage   Expression Level
embryo 00-02hr
 
 12425
embryo 02-04hr
 
 25874
embryo 04-06hr
 
 40162
embryo 06-08hr
 
 34027
embryo 08-10hr
 
 21391
embryo 10-12hr
 
 11980
embryo 12-14hr
 
 7862
embryo 14-16hr
 
 4230
embryo 16-18hr
 
 4171
embryo 18-20hr
 
 2499
embryo 20-22hr
 
 3448
embryo 22-24hr
 
 4121
larva L1
 
 1736
larva L2
 
 3586
larva L3 12hr old
 
 2733
larva L3 puffstage 1-2
 
 5124
larva L3 puffstage 3-6
 
 6545
larva L3 puffstage 7-9
 
 8693
white prepupae new
 
 7984
white prepupae 12hr
 
 9108
white prepupae 24hr
 
 10175
pupae 2d postWPP
 
 4614
pupae 3d postWPP
 
 2461
pupae 4d postWPP
 
 1332
adult male 01day
 
 1918
adult male 05day
 
 2438
adult male 30day
 
 1760
adult female 01day
 
 3304
adult female 05day
 
 7906
adult female 30day
 
 7870
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
Linear, scaled to Very low expression
Developmental Stage   Expression Level
embryo 00-02hr
 (12425)
embryo 02-04hr
 (25874)
embryo 04-06hr
 (40162)
embryo 06-08hr
 (34027)
embryo 08-10hr
 (21391)
embryo 10-12hr
 (11980)
embryo 12-14hr
 (7862)
embryo 14-16hr
 (4230)
embryo 16-18hr
 (4171)
embryo 18-20hr
 (2499)
embryo 20-22hr
 (3448)
embryo 22-24hr
 (4121)
larva L1
 (1736)
larva L2
 (3586)
larva L3 12hr old
 (2733)
larva L3 puffstage 1-2
 (5124)
larva L3 puffstage 3-6
 (6545)
larva L3 puffstage 7-9
 (8693)
white prepupae new
 (7984)
white prepupae 12hr
 (9108)
white prepupae 24hr
 (10175)
pupae 2d postWPP
 (4614)
pupae 3d postWPP
 (2461)
pupae 4d postWPP
 (1332)
adult male 01day
 (1918)
adult male 05day
 (2438)
adult male 30day
 (1760)
adult female 01day
 (3304)
adult female 05day
 (7906)
adult female 30day
 (7870)
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
Linear, scaled to Moderate expression
Developmental Stage   Expression Level
embryo 00-02hr
 (12425)
embryo 02-04hr
 (25874)
embryo 04-06hr
 (40162)
embryo 06-08hr
 (34027)
embryo 08-10hr
 (21391)
embryo 10-12hr
 (11980)
embryo 12-14hr
 (7862)
embryo 14-16hr
 (4230)
embryo 16-18hr
 (4171)
embryo 18-20hr
 (2499)
embryo 20-22hr
 (3448)
embryo 22-24hr
 (4121)
larva L1
 (1736)
larva L2
 (3586)
larva L3 12hr old
 (2733)
larva L3 puffstage 1-2
 (5124)
larva L3 puffstage 3-6
 (6545)
larva L3 puffstage 7-9
 (8693)
white prepupae new
 (7984)
white prepupae 12hr
 (9108)
white prepupae 24hr
 (10175)
pupae 2d postWPP
 (4614)
pupae 3d postWPP
 (2461)
pupae 4d postWPP
 
 1332
adult male 01day
 (1918)
adult male 05day
 (2438)
adult male 30day
 (1760)
adult female 01day
 (3304)
adult female 05day
 (7906)
adult female 30day
 (7870)
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
Linear, scaled to High expression
Developmental Stage   Expression Level
embryo 00-02hr
 (12425)
embryo 02-04hr
 (25874)
embryo 04-06hr
 (40162)
embryo 06-08hr
 (34027)
embryo 08-10hr
 (21391)
embryo 10-12hr
 (11980)
embryo 12-14hr
 
 7862
embryo 14-16hr
 
 4230
embryo 16-18hr
 
 4171
embryo 18-20hr
 
 2499
embryo 20-22hr
 
 3448
embryo 22-24hr
 
 4121
larva L1
 
 1736
larva L2
 
 3586
larva L3 12hr old
 
 2733
larva L3 puffstage 1-2
 
 5124
larva L3 puffstage 3-6
 
 6545
larva L3 puffstage 7-9
 
 8693
white prepupae new
 
 7984
white prepupae 12hr
 
 9108
white prepupae 24hr
 10175
pupae 2d postWPP
 
 4614
pupae 3d postWPP
 
 2461
pupae 4d postWPP
 
 1332
adult male 01day
 
 1918
adult male 05day
 
 2438
adult male 30day
 
 1760
adult female 01day
 
 3304
adult female 05day
 
 7906
adult female 30day
 
 7870
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
Linear, scaled to Extremely high expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 12425
embryo 02-04hr
 
 25874
embryo 04-06hr
 
 40162
embryo 06-08hr
 
 34027
embryo 08-10hr
 
 21391
embryo 10-12hr
 
 11980
embryo 12-14hr
 
 7862
embryo 14-16hr
 
 4230
embryo 16-18hr
 
 4171
embryo 18-20hr
 
 2499
embryo 20-22hr
 
 3448
embryo 22-24hr
 
 4121
larva L1
 
 1736
larva L2
 
 3586
larva L3 12hr old
 
 2733
larva L3 puffstage 1-2
 
 5124
larva L3 puffstage 3-6
 
 6545
larva L3 puffstage 7-9
 
 8693
white prepupae new
 
 7984
white prepupae 12hr
 
 9108
white prepupae 24hr
 
 10175
pupae 2d postWPP
 
 4614
pupae 3d postWPP
 
 2461
pupae 4d postWPP
 
 1332
adult male 01day
 
 1918
adult male 05day
 
 2438
adult male 30day
 
 1760
adult female 01day
 
 3304
adult female 05day
 
 7906
adult female 30day
 
 7870
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
 Extremely high 
log, scaled to maximum FBgn0003607 expression level
Developmental Stage   Expression Level
embryo 00-02hr
 
 12425
embryo 02-04hr
 
 25874
embryo 04-06hr
 
 40162
embryo 06-08hr
 
 34027
embryo 08-10hr
 
 21391
embryo 10-12hr
 
 11980
embryo 12-14hr
 
 7862
embryo 14-16hr
 
 4230
embryo 16-18hr
 
 4171
embryo 18-20hr
 
 2499
embryo 20-22hr
 
 3448
embryo 22-24hr
 
 4121
larva L1
 
 1736
larva L2
 
 3586
larva L3 12hr old
 
 2733
larva L3 puffstage 1-2
 
 5124
larva L3 puffstage 3-6
 
 6545
larva L3 puffstage 7-9
 
 8693
white prepupae new
 
 7984
white prepupae 12hr
 
 9108
white prepupae 24hr
 
 10175
pupae 2d postWPP
 
 4614
pupae 3d postWPP
 
 2461
pupae 4d postWPP
 
 1332
adult male 01day
 
 1918
adult male 05day
 
 2438
adult male 30day
 
 1760
adult female 01day
 
 3304
adult female 05day
 
 7906
adult female 30day
 
 7870
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
 Extremely high 
log, scaled to Very low expression
Developmental Stage   Expression Level
embryo 00-02hr
 (12425)
embryo 02-04hr
 (25874)
embryo 04-06hr
 (40162)
embryo 06-08hr
 (34027)
embryo 08-10hr
 (21391)
embryo 10-12hr
 (11980)
embryo 12-14hr
 (7862)
embryo 14-16hr
 (4230)
embryo 16-18hr
 (4171)
embryo 18-20hr
 (2499)
embryo 20-22hr
 (3448)
embryo 22-24hr
 (4121)
larva L1
 (1736)
larva L2
 (3586)
larva L3 12hr old
 (2733)
larva L3 puffstage 1-2
 (5124)
larva L3 puffstage 3-6
 (6545)
larva L3 puffstage 7-9
 (8693)
white prepupae new
 (7984)
white prepupae 12hr
 (9108)
white prepupae 24hr
 (10175)
pupae 2d postWPP
 (4614)
pupae 3d postWPP
 (2461)
pupae 4d postWPP
 (1332)
adult male 01day
 (1918)
adult male 05day
 (2438)
adult male 30day
 (1760)
adult female 01day
 (3304)
adult female 05day
 (7906)
adult female 30day
 (7870)
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
log, scaled to Moderate expression
Developmental Stage   Expression Level
embryo 00-02hr
 (12425)
embryo 02-04hr
 (25874)
embryo 04-06hr
 (40162)
embryo 06-08hr
 (34027)
embryo 08-10hr
 (21391)
embryo 10-12hr
 (11980)
embryo 12-14hr
 (7862)
embryo 14-16hr
 (4230)
embryo 16-18hr
 (4171)
embryo 18-20hr
 (2499)
embryo 20-22hr
 (3448)
embryo 22-24hr
 (4121)
larva L1
 1736
larva L2
 (3586)
larva L3 12hr old
 (2733)
larva L3 puffstage 1-2
 (5124)
larva L3 puffstage 3-6
 (6545)
larva L3 puffstage 7-9
 (8693)
white prepupae new
 (7984)
white prepupae 12hr
 (9108)
white prepupae 24hr
 (10175)
pupae 2d postWPP
 (4614)
pupae 3d postWPP
 2461
pupae 4d postWPP
 
 1332
adult male 01day
 1918
adult male 05day
 2438
adult male 30day
 1760
adult female 01day
 (3304)
adult female 05day
 (7906)
adult female 30day
 (7870)
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
log, scaled to High expression
Developmental Stage   Expression Level
embryo 00-02hr
 12425
embryo 02-04hr
 (25874)
embryo 04-06hr
 (40162)
embryo 06-08hr
 (34027)
embryo 08-10hr
 (21391)
embryo 10-12hr
 11980
embryo 12-14hr
 
 7862
embryo 14-16hr
 
 4230
embryo 16-18hr
 
 4171
embryo 18-20hr
 
 2499
embryo 20-22hr
 
 3448
embryo 22-24hr
 
 4121
larva L1
 
 1736
larva L2
 
 3586
larva L3 12hr old
 
 2733
larva L3 puffstage 1-2
 
 5124
larva L3 puffstage 3-6
 
 6545
larva L3 puffstage 7-9
 
 8693
white prepupae new
 
 7984
white prepupae 12hr
 
 9108
white prepupae 24hr
 10175
pupae 2d postWPP
 
 4614
pupae 3d postWPP
 
 2461
pupae 4d postWPP
 
 1332
adult male 01day
 
 1918
adult male 05day
 
 2438
adult male 30day
 
 1760
adult female 01day
 
 3304
adult female 05day
 
 7906
adult female 30day
 
 7870
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
log, scaled to Extremely high expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 12425
embryo 02-04hr
 
 25874
embryo 04-06hr
 
 40162
embryo 06-08hr
 
 34027
embryo 08-10hr
 
 21391
embryo 10-12hr
 
 11980
embryo 12-14hr
 
 7862
embryo 14-16hr
 
 4230
embryo 16-18hr
 
 4171
embryo 18-20hr
 
 2499
embryo 20-22hr
 
 3448
embryo 22-24hr
 
 4121
larva L1
 
 1736
larva L2
 
 3586
larva L3 12hr old
 
 2733
larva L3 puffstage 1-2
 
 5124
larva L3 puffstage 3-6
 
 6545
larva L3 puffstage 7-9
 
 8693
white prepupae new
 
 7984
white prepupae 12hr
 
 9108
white prepupae 24hr
 
 10175
pupae 2d postWPP
 
 4614
pupae 3d postWPP
 
 2461
pupae 4d postWPP
 
 1332
adult male 01day
 
 1918
adult male 05day
 
 2438
adult male 30day
 
 1760
adult female 01day
 
 3304
adult female 05day
 
 7906
adult female 30day
 
 7870
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
 Extremely high 
Heatmap
Developmental Stage   Expression Level
embryo 00-02hr
 
 
embryo 02-04hr
 
 
embryo 04-06hr
 
 
embryo 06-08hr
 
 
embryo 08-10hr
 
 
embryo 10-12hr
 
 
embryo 12-14hr
 
 
embryo 14-16hr
 
 
embryo 16-18hr
 
 
embryo 18-20hr
 
 
embryo 20-22hr
 
 
embryo 22-24hr
 
 
larva L1
 
 
larva L2
 
 
larva L3 12hr old
 
 
larva L3 puffstage 1-2
 
 
larva L3 puffstage 3-6
 
 
larva L3 puffstage 7-9
 
 
white prepupae new
 
 
white prepupae 12hr
 
 
white prepupae 24hr
 
 
pupae 2d postWPP
 
 
pupae 3d postWPP
 
 
pupae 4d postWPP
 
 
adult male 01day
 
 
adult male 05day
 
 
adult male 30day
 
 
adult female 01day
 
 
adult female 05day
 
 
adult female 30day
 
 

FlyAtlas Anatomical Expression Data for FBgn0003607


   Styles
Linear
Logarithmic
Heatmap
Back-to-back
   Scales
max expr for FBgn0003607
Moderate expression bin max
High level expression bin max
Very high expression bin max

Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, larval hindgut, larval Malpighian tubules, larval salivary gland, larval trachea, adult ovary, adult male accessory gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult crop, larval/adult midgut, adult hindgut, adult Malpighian tubules, adult heart, larval/adult fat body, adult salivary gland, adult spermathecae, adult testis, larval/adult carcass.
[download data (TSV)]

Guide to FlyAtlas expression level colors
 
 No expression (0 - 9.999)
 
 Low expression (10 - 99.999)
 
 Moderate expression (100 - 499.999)
 
 High level expression (500 - 999.999)
 
 Very high expression (1000 - 25000)

Linear, scaled to maximum FBgn0003607 expression level
Tissue   Expression Level
Larval Central Nervous System
 
 1634.775
Larval Midgut
 
 331
Larval Hindgut
 
 500.5
Larval Malpighian Tubules
 
 526.7
Larval Fat Body
 
 395.2
Larval Salivary Gland
 
 652
Larval Trachea
 
 736.825
Larval Carcass
 
 469.15
Adult Head
 
 398.7
Adult Eye
 
 568.525
Adult Brain
 
 614.3
Adult Thoracic-Abdominal Ganglion
 
 507.2
Adult Crop
 
 412.1
Adult Midgut
 
 403.5
Adult Hindgut
 
 439
Adult Malpighian Tubules
 
 405.7
Adult Fat Body
 
 254.8
Adult Salivary Gland
 
 487.7
Adult Heart
 
 293.35
Adult VirginFemale Spermatheca
 
 433.2
Adult InseminatedFemale Spermatheca
 
 455
Adult Ovary
 
 1000.1
Adult Testis
 
 306.3
Adult Male Accessory Gland
 
 540.6
Adult Carcass
 
 287.4
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
Linear, scaled to Moderate expression
Tissue   Expression Level
Larval Central Nervous System
 (1634.775)
Larval Midgut
 
 331
Larval Hindgut
 500.5
Larval Malpighian Tubules
 526.7
Larval Fat Body
 
 395.2
Larval Salivary Gland
 (652)
Larval Trachea
 (736.825)
Larval Carcass
 
 469.15
Adult Head
 
 398.7
Adult Eye
 (568.525)
Adult Brain
 (614.3)
Adult Thoracic-Abdominal Ganglion
 507.2
Adult Crop
 
 412.1
Adult Midgut
 
 403.5
Adult Hindgut
 
 439
Adult Malpighian Tubules
 
 405.7
Adult Fat Body
 
 254.8
Adult Salivary Gland
 
 487.7
Adult Heart
 
 293.35
Adult VirginFemale Spermatheca
 
 433.2
Adult InseminatedFemale Spermatheca
 
 455
Adult Ovary
 (1000.1)
Adult Testis
 
 306.3
Adult Male Accessory Gland
 (540.6)
Adult Carcass
 
 287.4
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
Linear, scaled to High level expression
Tissue   Expression Level
Larval Central Nervous System
 (1634.775)
Larval Midgut
 
 331
Larval Hindgut
 
 500.5
Larval Malpighian Tubules
 
 526.7
Larval Fat Body
 
 395.2
Larval Salivary Gland
 
 652
Larval Trachea
 
 736.825
Larval Carcass
 
 469.15
Adult Head
 
 398.7
Adult Eye
 
 568.525
Adult Brain
 
 614.3
Adult Thoracic-Abdominal Ganglion
 
 507.2
Adult Crop
 
 412.1
Adult Midgut
 
 403.5
Adult Hindgut
 
 439
Adult Malpighian Tubules
 
 405.7
Adult Fat Body
 
 254.8
Adult Salivary Gland
 
 487.7
Adult Heart
 
 293.35
Adult VirginFemale Spermatheca
 
 433.2
Adult InseminatedFemale Spermatheca
 
 455
Adult Ovary
 1000.1
Adult Testis
 
 306.3
Adult Male Accessory Gland
 
 540.6
Adult Carcass
 
 287.4
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
Linear, scaled to Very high expression
Tissue   Expression Level
Larval Central Nervous System
 
 1634.775
Larval Midgut
 
 331
Larval Hindgut
 
 500.5
Larval Malpighian Tubules
 
 526.7
Larval Fat Body
 
 395.2
Larval Salivary Gland
 
 652
Larval Trachea
 
 736.825
Larval Carcass
 
 469.15
Adult Head
 
 398.7
Adult Eye
 
 568.525
Adult Brain
 
 614.3
Adult Thoracic-Abdominal Ganglion
 
 507.2
Adult Crop
 
 412.1
Adult Midgut
 
 403.5
Adult Hindgut
 
 439
Adult Malpighian Tubules
 
 405.7
Adult Fat Body
 
 254.8
Adult Salivary Gland
 
 487.7
Adult Heart
 
 293.35
Adult VirginFemale Spermatheca
 
 433.2
Adult InseminatedFemale Spermatheca
 
 455
Adult Ovary
 
 1000.1
Adult Testis
 
 306.3
Adult Male Accessory Gland
 
 540.6
Adult Carcass
 
 287.4
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
log, scaled to maximum FBgn0003607 expression level
Tissue   Expression Level
Larval Central Nervous System
 
 1634.775
Larval Midgut
 
 331
Larval Hindgut
 
 500.5
Larval Malpighian Tubules
 
 526.7
Larval Fat Body
 
 395.2
Larval Salivary Gland
 
 652
Larval Trachea
 
 736.825
Larval Carcass
 
 469.15
Adult Head
 
 398.7
Adult Eye
 
 568.525
Adult Brain
 
 614.3
Adult Thoracic-Abdominal Ganglion
 
 507.2
Adult Crop
 
 412.1
Adult Midgut
 
 403.5
Adult Hindgut
 
 439
Adult Malpighian Tubules
 
 405.7
Adult Fat Body
 
 254.8
Adult Salivary Gland
 
 487.7
Adult Heart
 
 293.35
Adult VirginFemale Spermatheca
 
 433.2
Adult InseminatedFemale Spermatheca
 
 455
Adult Ovary
 
 1000.1
Adult Testis
 
 306.3
Adult Male Accessory Gland
 
 540.6
Adult Carcass
 
 287.4
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
log, scaled to Moderate expression
Tissue   Expression Level
Larval Central Nervous System
 (1634.775)
Larval Midgut
 
 331
Larval Hindgut
 500.5
Larval Malpighian Tubules
 526.7
Larval Fat Body
 
 395.2
Larval Salivary Gland
 652
Larval Trachea
 736.825
Larval Carcass
 
 469.15
Adult Head
 
 398.7
Adult Eye
 568.525
Adult Brain
 614.3
Adult Thoracic-Abdominal Ganglion
 507.2
Adult Crop
 
 412.1
Adult Midgut
 
 403.5
Adult Hindgut
 
 439
Adult Malpighian Tubules
 
 405.7
Adult Fat Body
 
 254.8
Adult Salivary Gland
 
 487.7
Adult Heart
 
 293.35
Adult VirginFemale Spermatheca
 
 433.2
Adult InseminatedFemale Spermatheca
 
 455
Adult Ovary
 (1000.1)
Adult Testis
 
 306.3
Adult Male Accessory Gland
 540.6
Adult Carcass
 
 287.4
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
log, scaled to High level expression
Tissue   Expression Level
Larval Central Nervous System
 1634.775
Larval Midgut
 
 331
Larval Hindgut
 
 500.5
Larval Malpighian Tubules
 
 526.7
Larval Fat Body
 
 395.2
Larval Salivary Gland
 
 652
Larval Trachea
 
 736.825
Larval Carcass
 
 469.15
Adult Head
 
 398.7
Adult Eye
 
 568.525
Adult Brain
 
 614.3
Adult Thoracic-Abdominal Ganglion
 
 507.2
Adult Crop
 
 412.1
Adult Midgut
 
 403.5
Adult Hindgut
 
 439
Adult Malpighian Tubules
 
 405.7
Adult Fat Body
 
 254.8
Adult Salivary Gland
 
 487.7
Adult Heart
 
 293.35
Adult VirginFemale Spermatheca
 
 433.2
Adult InseminatedFemale Spermatheca
 
 455
Adult Ovary
 1000.1
Adult Testis
 
 306.3
Adult Male Accessory Gland
 
 540.6
Adult Carcass
 
 287.4
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
log, scaled to Very high expression
Tissue   Expression Level
Larval Central Nervous System
 
 1634.775
Larval Midgut
 
 331
Larval Hindgut
 
 500.5
Larval Malpighian Tubules
 
 526.7
Larval Fat Body
 
 395.2
Larval Salivary Gland
 
 652
Larval Trachea
 
 736.825
Larval Carcass
 
 469.15
Adult Head
 
 398.7
Adult Eye
 
 568.525
Adult Brain
 
 614.3
Adult Thoracic-Abdominal Ganglion
 
 507.2
Adult Crop
 
 412.1
Adult Midgut
 
 403.5
Adult Hindgut
 
 439
Adult Malpighian Tubules
 
 405.7
Adult Fat Body
 
 254.8
Adult Salivary Gland
 
 487.7
Adult Heart
 
 293.35
Adult VirginFemale Spermatheca
 
 433.2
Adult InseminatedFemale Spermatheca
 
 455
Adult Ovary
 
 1000.1
Adult Testis
 
 306.3
Adult Male Accessory Gland
 
 540.6
Adult Carcass
 
 287.4
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
Heatmap
Tissue   Expression Level
Larval Central Nervous System
 
 
Larval Midgut
 
 
Larval Hindgut
 
 
Larval Malpighian Tubules
 
 
Larval Fat Body
 
 
Larval Salivary Gland
 
 
Larval Trachea
 
 
Larval Carcass
 
 
Adult Head
 
 
Adult Eye
 
 
Adult Brain
 
 
Adult Thoracic-Abdominal Ganglion
 
 
Adult Crop
 
 
Adult Midgut
 
 
Adult Hindgut
 
 
Adult Malpighian Tubules
 
 
Adult Fat Body
 
 
Adult Salivary Gland
 
 
Adult Heart
 
 
Adult VirginFemale Spermatheca
 
 
Adult InseminatedFemale Spermatheca
 
 
Adult Ovary
 
 
Adult Testis
 
 
Adult Male Accessory Gland
 
 
Adult Carcass
 
 

FlyAtlas Organ/Tissue Expression, larval vs. adult
Larval Expression Level Tissue Adult Expression Level
 
NA 		 Head
 
 398.7
 
NA 		 Eye
 
 568.525
 
NA 		 Brain
 
 614.3
 
1634.775 		 Central Nervous System
 
 NA
 
NA 		 Thoracic-Abdominal Ganglion
 
 507.2
 
NA 		 Crop
 
 412.1
 
331 		 Midgut
 
 403.5
 
500.5 		 Hindgut
 
 439
 
526.7 		 Malpighian Tubules
 
 405.7
 
395.2 		 Fat Body
 
 254.8
 
652 		 Salivary Gland
 
 487.7
 
NA 		 Heart
 
 293.35
 
736.825 		 Trachea
 
 NA
 
NA 		 VirginFemale Spermatheca
 
 433.2
 
NA 		 InseminatedFemale Spermatheca
 
 455
 
NA 		 Ovary
 
 1000.1
 
NA 		 Testis
 
 306.3
 
NA 		 Male Accessory Gland
 
 540.6
 
469.15 		 Carcass
 
 287.4

modENCODE Temporal Expression Data (Graveley et al., 2011)
FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
hide Expression Clusters
A cluster of genes with similar mRNA expression dynamics across development.
(The modENCODE Consortium, 2010)
hide External Data & Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
•
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
•
FlyExpress - Embryonic expression images (BDGP data)
•
Show all FlyExpress processed images for Su(var)205
hide Alleles & Phenotypes
hide Summary of Allele Phenotypes
Lethality
Allele
lethal, with Scer\GAL41407
lethal (with Su(var)2052)
lethal (with Su(var)2054)
lethal | embryonic stage | maternal effect | recessive
lethal | pupal stage, with Scer\GAL4Act.PU
lethal | recessive
viable, with Scer\GAL4pnr-MD237
Other Phenotypes
Allele
enhancer of variegation
enhancer of variegation, with Ab(2;3)Tell-P{Winkelried(-FRT)}
enhancer of variegation, with Ab(2;3)Tell-P{Winkelried}D
enhancer of variegation, with In(1)sc8
enhancer of variegation, with In(1)wm4
enhancer of variegation, with In(2)Heidi-P{Winkelried(-FRT)}
enhancer of variegation, with In(2)Heidi-P{Winkelried}D
enhancer of variegation, with P{Winkelried}A7
enhancer of variegation, with T(2;3)SbV
enhancer of variegation (with Su(var)2055), with ltunspecified
enhancer of variegation (with Su(var)205205), with ltunspecified
enhancer of variegation | dominant, with T(2;3)H33-6
enhancer of variegation | dominant, with T(2;3)H127-3
enhancer of variegation | dominant, with Tp(2;3)H76-7
increased cell death, with Su(var)205a.cDLa
increased cell death, with Su(var)205cDLa
increased cell death (with Su(var)2054)
increased cell death (with Su(var)2055)
neuroanatomy defective | larval stage, with Scer\GAL41407
non-enhancer of variegation, with In(1)wm4
non-enhancer of variegation, with In(1)wm4h
non-enhancer of variegation, with In(2)Heidi-P{Winkelried(-FRT)}
non-enhancer of variegation, with P{hsp26-pt-T}39C-5
non-enhancer of variegation, with P{hsp26-pt-T}39C-27
non-enhancer of variegation, with P{Winkelried(-FRT)}A7
non-enhancer of variegation, with P{Winkelried(-FRT)}A7, P{Winkelried}A7
non-enhancer of variegation, with Tp(3;Y)BL2
non-suppressor of variegation, with P{hsp26-pt-T}39C-5
non-suppressor of variegation, with P{hsp26-pt-T}39C-27
non-suppressor of variegation, with P{RS5}5-HA-1005
non-suppressor of variegation | dominant, with P{RS5}5-HA-1902
non-suppressor of variegation | dominant, with P{RS5}5-HA-1992
suppressor of variegation
suppressor of variegation, with Ab(2;3)Tell-P{Winkelried(-FRT)}
suppressor of variegation, with Ab(2;3)Tell-P{Winkelried}D
suppressor of variegation, with Byron
suppressor of variegation, with Dp(1;f)γ878
suppressor of variegation, with In(1)wm4
suppressor of variegation, with In(1)wm4h
suppressor of variegation, with In(2)Heidi-P{Winkelried(-FRT)}
suppressor of variegation, with In(2)Heidi-P{Winkelried}D
suppressor of variegation, with In(2R)bwVDe2
suppressor of variegation, with P{hsp26-pt-T}39C-56
suppressor of variegation, with P{hsp26-pt-T}39C-68
suppressor of variegation, with P{hsp26-pt-T}39C-72
suppressor of variegation, with P{hsp26-pt-T}118E-10
suppressor of variegation, with P{hsp26-pt-T}Dyrk3118E-15
suppressor of variegation, with P{hsp26-pt-T}Dyrk3118E-15, T(2;4)X-2
suppressor of variegation, with P{hsp26-pt-T}Dyrk3118E-15, T(2;4)X-4
suppressor of variegation, with P{hsp26-pt-T}Dyrk3118E-15, Tp(4;3)X-10
suppressor of variegation, with P{hsp26-pt-T}HS-2
suppressor of variegation, with P{hsp26-pt-T}HS-4
suppressor of variegation, with P{hsp26-pt-T}HS-6
suppressor of variegation, with P{T1(-FRT)}T190-177
suppressor of variegation, with P{T1}T190-177
suppressor of variegation, with P{wAR}41A
suppressor of variegation, with P{wAR}wA
suppressor of variegation, with P{wAL}YAL
suppressor of variegation, with w+mW.hs
suppressor of variegation | dominant
suppressor of variegation | dominant, with In(1)wm4
suppressor of variegation | dominant, with In(1)wm4h
suppressor of variegation | dominant, with P{hsp26-pt-T}39C-3
suppressor of variegation | dominant, with P{hsp26-pt-T}39C-12
suppressor of variegation | dominant, with P{hsp26-pt-T}39C-42
suppressor of variegation | dominant, with P{hsp26-pt-T}118E-3
suppressor of variegation | dominant, with P{hsp26-pt-T}118E-10
suppressor of variegation | dominant, with P{hsp26-pt-T}118E-19
suppressor of variegation | dominant, with P{hsp26-pt-T}118E-25-5
suppressor of variegation | dominant, with P{hsp26-pt-T}CG231639C-34
suppressor of variegation | dominant, with P{RS3}panCB-5204-3
suppressor of variegation | dominant, with T(2;3)SbV
suppressor of variegation | dominant, with T(2;3)V21-P{lacW}92E.x3
suppressor of variegation | recessive, with Dp(?;2)bwD
wild-type
Phenotype manifest in
Allele
chromosome, telomeric region
chromosome, telomeric region (with Su(var)2054)
chromosome, telomeric region (with Su(var)2055)
embryonic/larval neuroblast | larval stage, with Scer\GAL41407
embryonic/larval optic lobe
eye, with Scer\GAL4ey.PH
eye disc, with Scer\GAL4ey.PH
ganglion mother cell | larval stage, with Scer\GAL41407
imaginal disc
imaginal disc (with Su(var)2054)
imaginal disc (with Su(var)2055)
meiosis & nuclear chromosome | male
melanotic mass (with Df(2L)TE29Aa-11)
melanotic mass (with Su(var)2052)
melanotic mass (with Su(var)2054)
mitosis & chromosome, telomeric region
mitosis & nuclear chromosome (with Su(var)2054)
mitosis & nuclear chromosome (with Su(var)2055)
mitotic cell cycle, with Su(var)205a.cDLa
mitotic cell cycle, with Su(var)205cDLa
neuroblast, with Scer\GAL4Act.PU
neuroblast & larval brain
polytene chromosome
polytene chromosome (with Su(var)20503)
polytene chromosome (with Su(var)2054)
polytene chromosome (with Su(var)2055)
wing | posterior, with Scer\GAL4en-e16E
wing disc, with Scer\GAL4en-e16E
hide Classical Alleles ( 17 )
For All Classical Alleles Show

Allele of Su(var)205ClassMutagenStocksKnown lesion
Su(var)2055loss of function allele3 Yes
Su(var)20542 Yes
Su(var)20521 Yes
Su(var)205c068251 --
Su(var)205MB11439
1 --
Su(var)205030 --
Su(var)20510090 Yes
Su(var)20510970 Yes
Su(var)20512070 Yes
Su(var)2051490 Yes
Su(var)20515450 Yes
Su(var)20510 Yes
Su(var)205205
0 --
Su(var)205502
0 --
Su(var)205E39Ar10 Yes
Su(var)205P40 Yes
Su(var)205unspecified0 --
hide Alleles Carried on Transgenic Constructs ( 64 )
For All Alleles Carried on Transgenic Constructs Show

Allele of Su(var)205ClassMutagenStocksKnown lesion
Su(var)205GD125242 Yes
Su(var)205g.T:Avic\GFP1 Yes
Su(var)205g.T:Disc\RFP1 Yes
Su(var)205HMS002781 Yes
Su(var)205KK1108281 Yes
Su(var)205+tSa0 --
Su(var)2051.9kb0 Yes
Su(var)205151-206.T:Ecol\lacZ0 Yes
Su(var)205152-206.hs.T:Ecol\lacZ0 Yes
Su(var)205153.hs.T:Ecol\lacZ0 Yes
Su(var)2052-41.T:Ecol\lacZ0 Yes
Su(var)2052-95.T:Ecol\lacZ0 Yes
Su(var)205206.hs.T:Ecol\lacZ0 Yes
Su(var)20541-151.T:Ecol\lacZ0 Yes
Su(var)20541-153.hs.T:Ecol\lacZ0 Yes
Su(var)20541-206.hs.T:Ecol\lacZ0 Yes
Su(var)20541-95.hs.T:Ecol\lacZ0 Yes
Su(var)20541-95.T:Ecol\lacZ0 Yes
Su(var)20541.hs.T:Ecol\lacZ0 Yes
Su(var)20593-153.hs.T:Ecol\lacZ0 Yes
Su(var)20595-206.hs.T:Ecol\lacZ0 Yes
Su(var)20595.hs.T:Ecol\lacZ0 Yes
Su(var)205a.cDLa0 Yes
Su(var)205Ca-Sa.hs.T:Hsap\MYC0 Yes
Su(var)205Ca.hs.T:Avic\GFP0 Yes
Su(var)205CaHaSa.hs.T:Hsap\MYC0 Yes
Su(var)205cDLa0 Yes
Su(var)205CHa.hs.T:Avic\GFP0 Yes
Su(var)205CHa.hs.T:Hsap\MYC0 Yes
Su(var)205dsRNA.cGa0 Yes
Su(var)205dsRNA.Sym.Scer\UAS0 Yes
Su(var)205EEEAAA.hs.T:Ecol\lacZ0 Yes
Su(var)205Ha.hs.T:Avic\GFP0 Yes
Su(var)205HP1.T:Ecol\lacI,T:Avic\GFP0 Yes
Su(var)205hs.cFBa.T:Ecol\lacI0 Yes
Su(var)205hs.PE0 Yes
Su(var)205hs.PP0 Yes
Su(var)205hs.T:Ecol\dam,T:Hsap\MYC0 Yes
Su(var)205hs.T:Ecol\lacI0 Yes
Su(var)205hs.T:Hsap\MYC0 Yes
Su(var)205hs.T:Scer\GAL40 Yes
Su(var)205HSa.hs.T:Avic\GFP0 Yes
Su(var)205HSa.hs.T:Hsap\MYC0 Yes
Su(var)205KQ.hs.T:Ecol\lacZ0 Yes
Su(var)205NLS.hs.T:Ecol\lacZ0 Yes
Su(var)205RRQQ.hs.T:Ecol\lacZ0 Yes
Su(var)205S15A.hs.T:Ecol\lacZ0 Yes
Su(var)205S15A.hs0 Yes
Su(var)205S15A.S202A.hs.T:Ecol\lacZ0 Yes
Su(var)205S15E.hs.T:Ecol\lacZ0 Yes
Su(var)205S15E.hs0 Yes
Su(var)205S15E.S202A.hs0 Yes
Su(var)205S202A.hs.T:Ecol\lacZ0 Yes
Su(var)205S202A.hs0 Yes
Su(var)205S202E.hs.T:Ecol\lacZ0 Yes
Su(var)205S202E.hs0 Yes
Su(var)205Sa.hs.T:Avic\GFP0 Yes
Su(var)205Scer\UAS.T:Avic\GFP0 Yes
Su(var)205Scer\UAS.T:Ecol\dam.T:Hsap\MYC0 Yes
Su(var)205SS15.202AA.hs0 Yes
Su(var)205SSS102.103.104.AAA.hs0 Yes
Su(var)205SSS102.103.104.EEE.hs0 Yes
Su(var)205SSS89.90.91AAA.hs0 Yes
Su(var)205YF.hs.T:Ecol\lacZ0 Yes
hide Aneuploid Aberrations
Duplicated in
(Dorn et al., 1993)
(Dorn et al., 1993)
 
(Csink and Henikoff, 1996)
Not duplicated in
(Hwang et al., 2001)
Disrupted in
(Bushey and Locke, 2004, Bushey and Locke, 2004)
hide Transgenic Constructs & Insertions
Transgenic Constructs
Type of construct
Name
Expression data
reporter construct
P{EEE->AAA}
No
P{Gβ/41-95}
No
P{Gβ/41-153}
No
P{Gβ/41}
No
P{Gβ/95}
No
P{Gβ/153}
No
P{HP1.2-41-lacZ}
No
P{HP1.2-95-lacZ}
No
P{HP1.41-95-lacZ}
No
P{HP1.41-151-lacZ}
No
P{HP1.151-206-lacZ}
No
P{K->Q}
No
P{NLS}
No
P{RR->QQ}
No
P{Su(var)205S15A.hs.T:Ecol\lacZ}
No
P{Su(var)205S15A.S202A.hs.T:Ecol\lacZ}
No
P{Su(var)205S15E.hs.T:Ecol\lacZ}
No
P{Su(var)205S202A.hs.T:Ecol\lacZ}
No
P{Su(var)205S202E.hs.T:Ecol\lacZ}
No
P{Vβ/93-153}
No
P{Vβ/95-206}
No
P{Vβ/152-206}
No
P{Vβ/153}
No
P{Vβ/206}
No
P{Y->F}
No
heat-shock construct
P{EEE->AAA}
NA
P{Gβ/41-95}
NA
P{Gβ/41-153}
NA
P{Gβ/41}
NA
P{Gβ/95}
NA
P{Gβ/153}
NA
P{hs-GAL4-HP1}
NA
P{hs-HP1.lacI.BD}
NA
P{hs-HP1a.lacI}
NA
P{hs-Su(var)205.P}
NA
P{hs-Su(var)205.S15A}
NA
P{hs-Su(var)205.S15E,S202A}
NA
P{hs-Su(var)205.S15E}
NA
P{hs-Su(var)205.S202A}
NA
P{hs-Su(var)205.S202E}
NA
P{hs-Su(var)205.SS15,202AA}
NA
P{hs-Su(var)205.SSS89,90,91AAA}
NA
P{hs-Su(var)205.SSS102,103,104AAA}
NA
P{hs-Su(var)205.SSS102,103,104EEE}
NA
P{K->Q}
NA
P{neoRHSHP1}
NA
P{NLS}
NA
P{RR->QQ}
NA
P{Su(var)205S15A.hs.T:Ecol\lacZ}
NA
P{Su(var)205S15A.S202A.hs.T:Ecol\lacZ}
NA
P{Su(var)205S15E.hs.T:Ecol\lacZ}
NA
P{Su(var)205S202A.hs.T:Ecol\lacZ}
NA
P{Su(var)205S202E.hs.T:Ecol\lacZ}
NA
P{Vβ/93-153}
NA
P{Vβ/95-206}
NA
P{Vβ/152-206}
NA
P{Vβ/153}
NA
P{Vβ/206}
NA
P{Y->F}
NA
UAS construct
P{GD12524}
NA
P{KK110828}
NA
P{Sym-UAS-Su(var)205}
NA
P{TRiP.HMS00278}
NA
P{UAS-HP1.Dam.myc}
NA
P{UAS-Su(var)205-GFP}
NA
characterization construct
P{GFP-HP1}
NA
P{GS.ry+.Su(var)205.1.9kb}
NA
P{HP1-GFP-LacI}
NA
P{HP1-Pc}
NA
P{lacO.hsp26-SIP1.hsp70-w}
NA
P{RFP-HP1}
NA
P{Su(var)205+tSa}
NA
Insertions
Type of insertions
Name
Expression data
miscellaneous insertions
PBac{PB}Su(var)205c06825
NA
insertion of enhancer trap binary system
Mi{ET1}Su(var)205MB11439
No
hide Gene Ontology: Function, Process & Cellular Component ( 34 unique terms )
hide Terms Based on Experimental Evidence ( 27 terms )
Molecular Function
CV term
Evidence
References
chromatin binding
inferred from direct assay
(Johansson et al., 2007)
protein binding
inferred from physical interaction with Su(var)3-7
(Cleard et al., 1997)
rDNA binding
inferred from direct assay
(Blattes et al., 2006)
satellite DNA binding
inferred from direct assay
(Blattes et al., 2006)
Biological Process
CV term
Evidence
References
chromatin silencing
inferred from mutant phenotype
(Donaldson et al., 2002)
chromatin silencing at centromere
inferred from mutant phenotype
(Donaldson et al., 2002)
chromosome organization
inferred from mutant phenotype
(Demakova et al., 2007)
DNA hypermethylation
inferred from mutant phenotype
(Gou et al., 2010)
establishment of chromatin silencing
inferred from mutant phenotype
(Seum et al., 2001)
histone H4-K20 trimethylation
inferred from mutant phenotype
(Yang et al., 2008)
neurogenesis
inferred from mutant phenotype
(Neumüller et al., 2011)
regulation of apoptosis
inferred from mutant phenotype
(Liu et al., 2005)
regulation of histone methylation
inferred from mutant phenotype
(Liu et al., 2005)
regulation of transcription, DNA-dependent
inferred from mutant phenotype
(Liu et al., 2005)
telomere maintenance
inferred from mutant phenotype
(Perrini et al., 2004)
Cellular Component
CV term
Evidence
References
chromosome
inferred from direct assay
(Koch et al., 2009)
chromosome, telomeric region
inferred from direct assay
(Gao et al., 2010, Dubruille et al., 2010)
condensed chromosome
inferred from direct assay
(Shaffer et al., 2006)
condensed nuclear chromosome, centromeric region
inferred from direct assay
(Blattes et al., 2006)
heterochromatin
inferred from direct assay
(Shaffer et al., 2006)
nuclear heterochromatin
inferred from direct assay
(Shaffer et al., 2002)
nucleus
inferred from direct assay
(Blattes et al., 2006, Cleard et al., 1997)
polytene chromosome
inferred from direct assay
(Gause et al., 2008)
polytene chromosome, telomeric region
inferred from direct assay
(Piacentini et al., 2003, Fanti et al., 2003)
polytene chromosome band
inferred from direct assay
(Seong et al., 2011)
polytene chromosome chromocenter
inferred from direct assay
(Piacentini et al., 2003, Font-Burgada et al., 2008, Fanti et al., 2003, Seong et al., 2011)
polytene chromosome puff
inferred from direct assay
(Piacentini et al., 2003, Fanti et al., 2003)
hide Terms Based on Predictions or Assertions ( 14 terms )
Molecular Function
CV term
Evidence
References
chromatin binding
inferred from sequence or structural similarity with mouse Cbx1
(FlyBase, 1992-)
histone binding
non-traceable author statement
(Kellum, 2003)
methylated histone residue binding
traceable author statement
(Simms et al., 2003)
mRNA binding
non-traceable author statement
(Kellum, 2003)
Biological Process
CV term
Evidence
References
negative regulation of transcription, DNA-dependent
non-traceable author statement
(Kellum, 2003)
positive regulation of transcription, DNA-dependent
traceable author statement
(Kellum, 2003)
Cellular Component
CV term
Evidence
References
centromeric heterochromatin
non-traceable author statement
(Gonzalez and Bornens, 2000)
chromosome, centromeric region
non-traceable author statement
(Kellum, 2003)
traceable author statement
(Zhimulev and Belyaeva, 2003)
chromosome, telomeric region
non-traceable author statement
(Gonzalez and Bornens, 2000)
heterochromatin
non-traceable author statement
(Kellum, 2003)
traceable author statement
(Zhimulev and Belyaeva, 2003)
nucleus
non-traceable author statement
(Swiss-Prot Project Members, 1987.8.13)
polytene chromosome, telomeric region
traceable author statement
(Zhimulev and Belyaeva, 2003)
polytene chromosome chromocenter
traceable author statement
(Zhimulev and Belyaeva, 2003)
polytene chromosome puff
traceable author statement
(Kellum, 2003)
hide Sequence Ontology: Class of Gene
nuclear_gene
 
protein_coding_gene
 
hide Interactions & Pathways
hide Summary of Physical Interactions
Protein-protein
Interacting group
Assay
References
hide Summary of Genetic Interactions
Interacts with
Please look at the allele data for full details of the genetic interactions
Su(var)205 allele
Gene
References
Su(var)2051
RpL15
(Schulze et al., 2005)
Su(var)2055
w
(Balasov et al., 2000)
Su(var)205205
rl
(Lu et al., 2000)
Su(var)205hs.T:Ecol\lacI
w
(Li et al., 2003)
Su(var)205unspecified
rl
(Sinclair et al., 2000)
unspecified
Su(var)3-7
(Cleard et al., 1997)
w
(Ahmad and Golic, 1996)
wwg
(Yoo et al., 2001)
hide External Data
Linkouts
BioGRID - A database of protein and genetic interactions
•
DPiM - DPiM, Drosophila Protein interaction Map
•
DroID - A comprehensive database of gene and protein interactions.
•
InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.
•
hide Orthologs
Genome-wide drosophilid orthologs
Curated drosophilid orthologs
 
 
 
Linkouts
InParanoid A subset of ortholog calls from InParanoid.
•
OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs.
•
hide Stocks & Reagents
hide Stocks Listed in FlyBase ( 14 )
Bloomington
30561
w1118; P{GFP-HP1}3
30562
w1118; P{RFP-HP1}3
27865
w1118; Mi{ET1}Su(var)205MB11439
33400
y1 sc* v1; P{TRiP.HMS00278}attP2
6234
In(1)wm4h; Su(var)2055/In(2L)Cy, In(2R)Cy, Cy1
Harvard
-
PBac{PB}Su(var)205c06825
Kyoto
101822
In(1)wm4h ; Su(var)2052 / SM1
108692
In(1)wm4h; Su(var)2055/In(2L)Cy, In(2R)Cy, Cy1
103332
In(1)wm4h ; Su(var)2055 / In(2L)Cy, In(2R)Cy, Cy1
VDRC
v107477
P{KK110828}VIE-260B
v31994
w1118; P{GD12524}v31994
v31995
w1118; P{GD12524}v31995
hide Genomic Clones ( 1 )

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
hide cDNA Clones ( 61 )

Please Note
This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
hide RNAi & Array Information
Linkouts
DRSC - Results from RNAi screens.
•
GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
•
hide Antibody Information
monoclonal
(Chiolo et al., 2011)
polyclonal
(Gou et al., 2010, Font-Burgada et al., 2008)
hide Other Information
hide Discoverer
hide Etymology
hide Identification
hide Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
hide Other Comments
DNA-protein interactions: genome-wide binding profile assayed for Su(var)205 protein in Kc167 cells; see Chromatin_types_NKI collection report. Individual protein-binding experiments listed under "Samples" at GEO_GSE22069 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE22069).
(Filion et al., 2010)
Expression is enriched in embryonic gonads.
(Shigenobu et al., 2006)
The Su(var)205 protein modulates chromosomal integrity, histone modifications and transcription in a sex-specific manner.
(Liu et al., 2005)
The binding of Su(var)205 protein to many, but not all, target loci is dependent on Su(var)3-9.
(Greil et al., 2003)
Methyl-K9 His3 protein and Su(var)205 protein co-localise to the heterochromatic region of polytene chromosomes.
(Jacobs et al., 2001)
Su(var)205 may facilitate the coalescence of dispersed middle repetitive sequences, and organise the heterochromatic structure responsible for the variegated silencing of nearby euchromatic genes.
(Seum et al., 2001)
Su(var)205 is required for normal transcriptional activation of heterochromatic genes.
(Lu et al., 2000)
A consensus pentapeptide is sufficient for specific interaction with the Su(var)205 chromo shadow domain. Su(var)205 dimerisation occurs via pentapeptide binding.
(Smothers and Henikoff, 2000)
Mutations in Su(var)205 suppress telomeric Position Effect Variegation (PEV) on the fourth chromosome, but not the second and third chromosomes.
(Cryderman et al., 1999)
The Su(var)205 product, HP1, targets the chromatin of transposon insertions and binds more densely at a site with repeated sequences susceptible to heterochromatin formation. Sufficient density of Su(var)205 protein association is a necessary step in heterochromatin formation and gene silencing.
(Fanti et al., 1998)
Actr13E colocalises with Su(var)205 in the centric heterochromatin throughout prepupal development and the two proteins undergo a series of changes in nuclear distribution that coincide with major shifts in nuclear functions.
(Frankel et al., 1997)
Naturally occurring regulatory P-elements inserted at the telomere of the X chromosome have been isolated in a genomic context devoid of other P-elements. One or two copies of autonomous P-elements at this site (1A) are sufficient to elicit a strong P repression in the germline. Regulatory properties of the P-elements at 1A are strongly impaired by mutation of Su(var)205.
(Ronsseray et al., 1997)
The regulatory properties of P-elements at 1A are affected by mutants at Su(var)205.
(Ronsseray et al., 1996)
Su(var)205 protein contains a second chromo domain-like motif, the 'chromo shadow domain', in the C-terminal part of the protein.
(Aasland and Stewart, 1995)
Studies of the embryonic lethality of mutants demonstrates that in addition to its effect on position-effect variegation, Su(var)205 is also required for normal nuclear morphology and mitosis.
(Kellum and Alberts, 1995)
The intracellular localisation of Su(var)205 in the diploid nuclei of embryos before and after developmental changes that occur between cycles 10 and 14 is studied.
(Kellum et al., 1995)
Point mutations in the chromo domain of Su(var)205 abolish its ability to promote homeotic gene silencing. The chromo domain has chromosome binding activity. Pc also has a chromo domain, a chimeric Su(var)205-Pc protein (the chromo domain of Pc in the context of Su(var)205) causes mislocalisation of Su(var)205 to Pc binding sites and expression in transgenic flies promotes heterochromatin mediated gene silencing. Results support the view that the chromo domain homology reflects a common mechanistic basis for homeotic and heterochromatic silencing.
(Platero et al., 1995)
Su(var)205 is multiply phosphorylated in tissues, predominantly at Ser and Thr residues. Maternally synthesised Su(var)205 protein is under phosphorylated. At 1.5-2 hours of development, when cytologically visible heterochromatin appears, the more phosphorylated Su(var)205 isoforms appear. Results are consistent with a role for phosphorylation of Su(var)205 in the assembly and maintenance of heterochromatin.
(Eissenberg et al., 1994)
The presence of Su(var)205 does not have any discernible effect on wzm, wzl, wzvl, wzh or wcres, this was not checked in X/0 males.
(Peterson et al., 1994)
Heterochromatin-associated Su(var)205 gene product appears in euchromatic chromosomal regions that are inactivated as a result of position-effect variegation.
(Belyaeva et al., 1993)
Analysis of the subcellular localisation of Ecol\lacZ-Su(var)205 fusion proteins shows that amino acids 152-206 form the nuclear localisation domain and amino acids 95 to 206 form the heterochromatin binding domain of the Su(var)205 protein.
(Powers and Eissenberg, 1993)
Su(var)205 homologue has been cloned from D.virilis: a high degree of conservation in N- and C-terminal domains of the encoded DNA-binding protein "HP1" suggests that these domains could interact with other macromolecules in the formation of the condensed structure of heterochromatin.
(Clark and Elgin, 1992)
Su(var)205 gene product is an essential protein that functions as a part of an epigenetic mechanism capable of generating and maintaining an inactive chromatin structure.
(Eissenberg et al., 1992)
Alleles show additive effects with mod alleles on suppression of In(1)wm4 position effect variegation.
(Garzino et al., 1992)
Su(var)205 protein, detected by the C1A9 antibody in polytene chromosomes, is preferentially located in the beta-heterochromatin, the basal regions of the polytene chromosome arms and throughout chromosome 4.
(James et al., 1989)
Triplo-dependent enhancer of variegation.
(Tartof et al., 1989)
The variegation enhancer phenotype is due to increase in gene dosage: independently derived duplications of Su(var)205 act as enhancers and reversion of the dominant enhancer phenotype corresponds with the loss of the duplication.
(Locke et al., 1988)
triplo-enhancer; duplications for the locus cause enhancement of variegation (Tartof, Bishop, Jones, Hobbs and Locke, 1989).
 
Encodes a nonhistone chromosomal protein, which by immunofluorescent staining of polytene chromosomes with a monoclonal antibody, is localized to α, β, and intercalary heterochromatin as well as chromosome 4 (FBrf0045031).
 
hide External Crossreferences & Linkouts
Sequence Crossreferences
RefSeq (Transcripts)
•
RefSeq (Proteins)
•
DDBJ / EMBL / GenBank
•
Entrez Gene - A searchable database of RefSeq genes.
•
UniProtKB/Swiss-Prot
•
Other Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
•
Chromo domain subgroup (IPR017984)
Chromo shadow, subgroup (IPR018125)
Chromo domain/shadow (IPR000953)
Chromo shadow (IPR008251)
Chromo domain-like (IPR016197)
Chromo domain, conserved site (IPR023779)
Chromo domain (IPR023780)
PDB - Protein Data Bank. An information portal to biological macromolecular structures
•
Linkouts
BioGRID - A database of protein and genetic interactions
•
DPiM - DPiM, Drosophila Protein interaction Map
•
DroID - A comprehensive database of gene and protein interactions.
•
DRSC - Results from RNAi screens.
•
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
•
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
•
FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans
•
GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
•
InParanoid A subset of ortholog calls from InParanoid.
•
Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
•
InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.
•
modMine - Data generated by the modENCODE project.
•
OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs.
•
hide Synonyms & Secondary IDs ( 48 )
Reported As
Symbol Synonym
CG8409
(Fakhouri et al., 2006, Przewloka et al., 2007, Greil et al., 2007, Keleman et al., 2009.8.5, Chen et al., 2008, Ni et al., 2010.12.1, Cammarato et al., 2011)
dHP1
(Wisniewski et al., 1999)
dHP-1a
(Bassett et al., 2008)
DmHP1
(Norwood et al., 2004)
DmHP-1
(Bertram and Pereira-Smith, 2001)
E(var)29
(Tartof et al., 1989, )
E(var)29A
 
FBgn0003607
(Lehmann et al., 2010)
H3
(Fanti et al., 2008)
HP1
(Sweeney et al., 2008, Seum et al., 2007, Nisha et al., 2008, Carre et al., 2005, Zhang et al., 2006, Eissenberg, 2006, Orian, 2006, Varga-Weisz, 2006, Kavi et al., 2005, Ivanovska et al., 2005, Louis and Vershinin, 2005, Kamakaka, 2005, Schulze et al., 2005, Swaminathan et al., 2005, Ahmad, 2004, Perrini et al., 2004, Ebert et al., 2004, Danzer and Wallrath, 2004, Sanchez-Elsner and Sauer, 2004, Piacentini et al., 2003, de la Cruz et al., 2005, Craig, 2005, Levine et al., 2004, Lund and van Lohuizen, 2004, Purdy and Su, 2004, Huertas et al., 2004, Ciapponi et al., 2004, Cao and Zhang, 2004, van Steensel et al., 2005, Peng et al., 2005, Hines et al., 2005, Adu-Wusu et al., 2005, Lippman and Martienssen, 2004, Korge et al., 2003, Josse et al., 2003, Ebert et al., 2003, Brehm et al., 2004, Kosak and Groudine, 2004, Schotta et al., 2004, Workman and Abmayr, 2004, Pal-Bhadra et al., 2004, Belyaeva et al., 2003, Sural and Kuroda, 2004, Shaffer et al., 2004, Ronsseray et al., 2004, Oikemus et al., 2004, Zhimulev and Belyaeva, 2003, Simms et al., 2003, Greil et al., 2003, Boivin et al., 2003, Biessmann and Mason, 2003, Anonymous, 2003, McNairn and Gilbert, 2003, Berg et al., 2003, Grewal and Moazed, 2003, Jaskelioff and Peterson, 2003, Sun et al., 2003, Salvaing et al., 2003, Kellum, 2003, Cenci et al., 2003, Moazed, 2001, Schotta et al., 2002, Cowell et al., 2002, Li et al., 2003, Gerbi and Bielinsky, 2002, Wallrath et al., 2000, Blower and Karpen, 2001, Orlando, 2003, Neely and Workman, 2002, Dillon and Festenstein, 2002, Shaffer, 2002.11.14, Stephens et al., 2003, Li et al., 2003, Cryderman et al., 2003, Danzer et al., 2003, Shaffer et al., 2002, Fourel et al., 2002, Jacobs and Khorasanizadeh, 2002, Jaquet et al., 2002, Elgin et al., 2001, Delattre et al., 2002, Richards and Elgin, 2002, Badugu and Kellum, 2002, Li et al., 2002, Grade et al., 2002, Lynn et al., 2002, Hwang et al., 2001, Siriaco et al., 2002, Jenuwein and Allis, 2001, Volpe et al., 2001, Zhang and Reinberg, 2001, Eissenberg, 2001, Hwang et al., 2001, Jacobs et al., 2001, Wallrath et al., 2001, Seum et al., 2000, Shareef et al., 2001, Hari et al., 2001, van Steensel et al., 2001, Martienssen, 2001, Eissenberg and Hilliker, 2000, Ahmad and Henikoff, 2001, Wallrath, 2000, Barlow et al., 2001, Ma et al., 2001, van Steensel et al., 2001, Sanjuan and Marin, 2001, Zhao et al., 2001, Seum et al., 2001, Eissenberg et al., 2001, Van Steensel et al., 2001, Shareef et al., 2001, Seum et al., 2001, Li et al., 2001, Danzer et al., 2001, Delattre et al., 2000, Zhao et al., 2000, Gebuhr et al., 2000, Anonymous, 2000, Eissenberg and Elgin, 2000, Birchler et al., 2000, Shaffer et al., 2000, van Steensel and Henikoff, 2000, Cenci et al., 2000, Naumova et al., 2000, Cryderman et al., 2000, Li et al., 2000, Smothers and Henikoff, 2000, Elgin et al., 1999, Siriaco et al., 1999, Schotta et al., 1999, Delattre et al., 1999, Cryderman et al., 1999, Cryderman et al., 1999, Cortes et al., 1999, Wallrath et al., 1998, Elgin et al., 1998, Zhao and Eissenberg, 1999, Dobie et al., 1999, Kornberg and Lorch, 1999, Aasland, 1999, Sun et al., 1999, Cryderman et al., 1999, Bernat et al., 1999, Aasland, 1999, Fanti et al., 1998, Fanti et al., 1998, Huang et al., 1998, Cavalli and Paro, 1998, Wallrath, 1998, Anonymous, 1998, Singh and Huskisson, 1998, Platero et al., 1998, Nelson et al., 1998, Sun et al., 1998, Gregory and Horz, 1998, Lu and Eissenberg, 1998, Zuckerkandl, 1997, Nelson and Tomkiel, 1997, Huang and Kellum, 1997, Elgin et al., 1997, Pak et al., 1997, Wilkins and Lis, 1997, Goldman, 1997, Wakimoto, 1997, Cleard et al., 1997, Frankel et al., 1997, Pirrotta, 1997, Belyaeva et al., 1997, Balasov and Makunin, 1996, Hilfiker et al., 1997, Huang and Kellum, 1996, Platero et al., 1997, Svaren and Hoerz, 1996, Platero et al., 1996, Aasland and Stewart, 1995, Koonin et al., 1995, Platero et al., 1995, Ngan et al., 1995, Kellum et al., 1995, Kellum and Alberts, 1995, Kellum and Alberts, 1994, Elgin et al., 1994, Becker, 1994, Eissenberg et al., 1994, Carlson and Laurent, 1994, Kellum and Alberts, 1993, Eissenberg and Hartnett, 1993, Belyaeva et al., 1993, Shaffer et al., 1993, Saunders et al., 1993, Powers and Eissenberg, 1993, Epstein et al., 1992, Singh et al., 1991, Elgin, 1990, James et al., 1989, Andreyeva et al., 2005, Peng and Karpen, 2006, Deng et al., 2006, Barbash et al., 2006, Birchler et al., 2005, Straub and Becker, 2007, Grewal and Elgin, 2007, Liu et al., 2005, Raffa et al., 2005, Shaffer et al., 2006, Deshpande et al., 2006, Demakova et al., 2007, Shi et al., 2007, Nisha and Csink, 2007, Dronamraju and Mason, 2007, Cryderman et al., 2007, Ronsseray et al., 2007, Li et al., 2007, Brideau et al., 2007, Christensen et al., 2007, Melcer and Gruenbaum, 2006, Brandt et al., 2006, Yasuhara and Wakimoto, 2006, Cavalli, 2006, Budde, 2007, Goldberg et al., 2007, Morris and Moazed, 2007, Zaratiegui, 2007, Blattes et al., 2006, Gvozdev et al., 2005, Oikemus et al., 2007, Ciapponi et al., 2006, Cryderman et al., 2005, Klenov et al., 2007, Badugu et al., 2005, Cenci et al., 2005, Ronsseray et al., 2007, Zhimulev et al., 2007, Lee et al., 2007, De Lucia et al., 2005, Minervini et al., 2007, Vermaak et al., 2005, Wallace and Orr-Weaver, 2005, Brideau et al., 2006, Haynes et al., 2006, Koryakov et al., 2006, Chen et al., 2008, Yan et al., 2011, Birchler et al., 2006, Hediger and Gasser, 2006, Savitsky et al., 2002, Nakayama et al., 2007, Bai et al., 2007, Brideau and Barbash, 2008, Koch et al., 2008, Sharakhov et al., 2008, Cryderman et al., 2008, Riddle et al., 2008, Yin and Lin, 2007, Wang et al., 2005, Min et al., 2003, Fischle et al., 2003, Schwendemann et al., 2008, Fahrner and Baylin, 2003, Li et al., 2002, van Steensel and Henikoff, 2000, Sun et al., 2004, Deng et al., 2007, de Wit et al., 2007, Josse et al., 2007, Johansson et al., 2007, Srinivasan et al., 2008, Greil et al., 2007, Tzeng et al., 2007, Johansson et al., 2007, Zhang et al., 2008, Cummings et al., 2007, Remaud et al., 2008, Pathak et al., 2007, Delattre et al., 2004, Shi et al., 2008, Wen et al., 2008, Spierer et al., 2005, Pindyurin et al., 2007, Pindyurin et al., 2008, Peng and Karpen, 2007, Frydrychova et al., 2008, Lu et al., 2009, Joppich et al., 2009, Komonyi et al., 2009, Raffa et al., 2009, Shevelyov et al., 2009, Lloret-Llinares et al., 2008, Vogel et al., 2009, Zhao et al., 2009, Brower-Toland et al., 2009, Wagner et al., 2007, Cortes et al., 2003, Shareef et al., 2003, Fanti et al., 2003, Cenci et al., 2003, Nie et al., 2009, Linder et al., 2001, Lee et al., 2009, Schneiderman et al., 2009, Gracheva et al., 2009, Pinto et al., 2008, Brandt, 2006, Hines et al., 2009, Shi et al., 2006, Pickersgill et al., 2006, Tolhuis et al., 2006, Oikemus et al., 2006, Stephens et al., 2005, Stephens et al., 2006, Scaria et al., 2008, Gao et al., 2010, Koch et al., 2009, Yoon et al., 2008, Fagegaltier et al., 2009, Lipsick, 2010.4.22, de Wit et al., 2008, de Wit et al., 2005, van Steensel et al., 2010, Schwaiger et al., 2010, Hofmann et al., 2010, Gause et al., 2008, Todeschini et al., 2010, Raffa et al., 2010, Huang et al., 2010, Bulchand et al., 2010, Moshkovich and Lei, 2010, Apger et al., 2010, Filion et al., 2010, Dubruille et al., 2010, Sasai et al., 2007, Brideau and Barbash, 2011, Dialynas et al., 2010, Seong et al., 2011, Kim et al., 2010, Li et al., 2011)
HP-1
(Henikoff, 2005, Grewal and Elgin, 2002, Marhold et al., 2002, Lynn and Lloyd, 2001, Wakimoto, 1998, Marshall and Wilson, 1997, Shaffer et al., 1996, Marshall et al., 1995, Manak and Scott, 1994, Eissenberg et al., 1992, Clark and Elgin, 1991, Eissenberg et al., 1990, Eissenberg et al., 1990, Balasov, 2002)
Hp1
(Christensen and Tye, 2003, Shannon and Rao, 2002, Plata et al., 2009, Apger et al., 2010)
hp1
(Rong, 2008)
HP1A
(Hiatt et al., 2007, Vermaak et al., 2005)
HP1a
(Osouda et al., 2005, Badugu et al., 2003, Smothers and Henikoff, 2001, Talbert and Henikoff, 2006, Liu et al., 2005, Yasuhara and Wakimoto, 2006, Moorman et al., 2006, Moorman et al., 2006, Lau et al., 2009, Przewloka et al., 2007, Brower-Toland et al., 2007, Lin et al., 2008, Abel et al., 2009, Pek et al., 2009, Schulze et al., 2009, Piacentini et al., 2009, Emelyanov et al., 2010, Kwon et al., 2010, Pek and Kai, 2011, modENCODE Consortium et al., 2010, Zhang et al., 2011, Mendez et al., 2011, Cryderman et al., 2011, Li et al., 2011)
Hp1a
(Doheny et al., 2008)
hp1a
(Font-Burgada et al., 2008)
HP1-VS
(Ngan, 1995.9.21)
HP1α
(Cao et al., 2002, Straub et al., 2005)
Su(var)
(Dunn et al., 2001)
Su(var)2-5
(Riddle et al., 2008, Schulze et al., 2009, Piacentini et al., 2009, Eissenberg, 2006, Schulze et al., 2005, Swaminathan et al., 2005, Ebert et al., 2004, Erhardt et al., 2003, Dimitri et al., 2005, Perrod and Gasser, 2003, Norwood et al., 2004, Bernard and Allshire, 2002, Belyaeva et al., 2003, Segal et al., 2004, Cenci et al., 2004, Zhimulev and Belyaeva, 2003, Kelley and Kuroda, 2003, Cenci et al., 2003, Schotta et al., 2002, Choo, 2001, Grewal and Elgin, 2002, Blower and Karpen, 2001, Yoo et al., 2003, Delattre et al., 2002, Donaldson et al., 2002, Richards and Elgin, 2002, Blower and Karpen, 2002, Georgiev et al., 2002, Cenci et al., 2002, Westphal and Reuter, 2002, Jenuwein and Allis, 2001, Hwang et al., 2001, Seum et al., 2000, Eissenberg and Hilliker, 2000, Sun et al., 2001, McKee et al., 2000, Gvozdev et al., 2000, Ma et al., 2001, Gasser, 2001, Yoo et al., 2001, Balasov et al., 2000, Balasov et al., 2000, Gebuhr et al., 2000, Lu et al., 2000, Eissenberg and Elgin, 2000, Sun et al., 2000, Naumova et al., 2000, Delattre et al., 1999, Cryderman et al., 1999, Cryderman et al., 1999, Sun et al., 1999, Fanti et al., 1998, Cryderman et al., 1998, Cavalli and Paro, 1998, Sass and Henikoff, 1998, Cleard et al., 1997, Cleard and Spierer, 1997, Dorn et al., 1993, Eissenberg et al., 1990, Demakova et al., 2007, Li et al., 2003, Seum et al., 2001, Cryderman et al., 2005, Joanis and Lloyd, 2002, Cenci et al., 2005, Haigh and Lloyd, 2007, Shpiz et al., 2007, Lam et al., 2005, Yan et al., 2011, Koryakov et al., 2006, Savitsky et al., 2002, Schwendemann et al., 2008, Fahrner and Baylin, 2003, Li et al., 2002, Brower-Toland et al., 2007, Sun et al., 2004, Deng et al., 2007, Andreyeva et al., 2007, Doheny et al., 2008, Spierer et al., 2005, Yang et al., 2008, Pindyurin et al., 2008, Lu et al., 2009, Lin et al., 2008, Joppich et al., 2009, Fanti et al., 2003, Cenci et al., 2003, Hines et al., 2009, Bazin et al., 2004, Phalke et al., 2009, Balasov, 2002, Gause et al., 2008, Todeschini et al., 2010, Prabhakaran and Kelley, 2010, Hofmann et al., 2010, Emelyanov et al., 2010, Moshkovich and Lei, 2010, Kwon et al., 2010, Cryderman et al., 2011)
Su(Var)2-5
(Naumova et al., 1999)
Su(var)2-05
(Demakova et al., 1998)
Su(var)2-501
(Netter et al., 1998)
Su(var)29A
(Locke et al., 1988)
Su(var)205
(Nisha et al., 2008, Liu et al., 2005, Minakhina and Steward, 2006, Prasad and Mason, 2007, Ronsseray et al., 2007, Yasuhara and Wakimoto, 2006, Shigenobu et al., 2006, Le et al., 2004, Haigh and Lloyd, 2007, Bi et al., 2005, Kalmykova et al., 2005, Gan et al., 2010, Yan et al., 2011, Kent, 2008, Ronsseray et al., 2008, Josse et al., 2007, Xing et al., 2007, Shi et al., 2008, Andreyeva et al., 2005, Frydrychova et al., 2008, Anderson et al., 2009, Linder et al., 2001, Shi et al., 2006, Musarò et al., 2008, Gim et al., 2001, Chen et al., 2008, Gou et al., 2010, Todeschini et al., 2010, Raffa et al., 2010, Simmons et al., 2010, Dubruille et al., 2010, Reis et al., 2011, Li et al., 2011, Neumüller et al., 2011)
su(var)205
(McVean and Vieira, 1999, Minakhina et al., 2007, Gao et al., 2010)
SU(VAR)205
(Lau et al., 2009)
Su(var)205
(Morcillo and MacIntyre, 2001, Gonzalez and Bornens, 2000)
SuVar205
(Vermaak et al., 2005)
Suvar205
(Cummings et al., 2007)
Suvar2-5
(Kellum and Alberts, 1995)
Suvar(2)5
(Singh and Huskisson, 1998, Sigrist and Pirrotta, 1997, Henikoff, 1996, Reuter and Spierer, 1992, Spradling and Karpen, 1990)
Su-var(2)5
(Wustmann et al., 1989)
Name Synonym
C1A9-nuclear-antigen
 
heterochromatic protein
(Gvozdev et al., 2005)
Heterochromatic Protein 1a
(Doheny et al., 2008)
heterochromatin-binding protein
(Dillon and Festenstein, 2002)
heterochromatin protein 1
(Kellum, 2003, Cryderman et al., 2000, Birchler et al., 2005, Liu et al., 2005, Shi et al., 2007, Vermaak et al., 2005, Koch et al., 2008, Fischle et al., 2003, Sun et al., 2004, Johansson et al., 2007, Shi et al., 2008, Linder et al., 2001, Schneiderman et al., 2009, Scaria et al., 2008, Koch et al., 2009, Balasov, 2002, van Steensel et al., 2010, Bulchand et al., 2010, Li et al., 2011)
Heterochromatin Protein 1
(Hari et al., 2001, Peng and Karpen, 2006, Cryderman et al., 2008, Josse et al., 2007, Remaud et al., 2008, Vogel et al., 2009, Fanti et al., 2003, Hines et al., 2009, Fagegaltier et al., 2009, Piacentini et al., 2009, Moshkovich and Lei, 2010)
heterochromatin-protein-1
(Eissenberg and Hartnett, 1993, Eissenberg et al., 1992, Yoon et al., 2008)
Heterochromatin protein 1
(Melcer and Gruenbaum, 2006, Brandt et al., 2006, Cryderman et al., 2005, Chen et al., 2008, de Wit et al., 2007, de Wit et al., 2005, Schwaiger et al., 2010)
heterochromatin protein-1
(Yoon et al., 2008)
Heterochromatin Protein 1A
(Hiatt et al., 2007)
Heterochromatin Protein 1a
(Moorman et al., 2006, Pek et al., 2009)
heterochromatin protein 1a
(Lau et al., 2009, Mendez et al., 2011)
Histone Protein 1
(Barbash et al., 2006)
Su(var)2-5
(Badugu et al., 2005)
Su(var)205
 
Suppressor of variegation 205
(Lau et al., 2009, Xing et al., 2007, Gim et al., 2001, Cammarato et al., 2011)
Secondary FlyBase IDs
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hide Recent research papers ( 35 )
Brideau and Barbash, 2011, BMC Evol. Biol. 11: 57
Functional conservation of the Drosophila hybrid incompatibility gene Lhr. [FBrf0213263]
Chiolo et al., 2011, Cell 144(5): 732--744
Double-Strand Breaks in Heterochromatin Move Outside of a Dynamic HP1a Domain to Complete Recombinational Repair. [FBrf0213146]
Cryderman et al., 2011, Transcription 2(2): 95--99
Heterochromatin protein 1a is required for an open chromatin structure. [FBrf0213370]
Dronamraju and Mason, 2011, PLoS ONE 6(9): e25439
MU2 and HP1a Regulate the Recognition of Double Strand Breaks in Drosophila melanogaster. [FBrf0216284]
Li et al., 2011, PLoS Genet. 7(6): e1002122
Cooperative and antagonistic contributions of two heterochromatin proteins to transcriptional regulation of the Drosophila sex determination decision. [FBrf0213989]
Mendez et al., 2011, Chembiochem 12(7): 1084--1096
The HP1a Disordered C Terminus and Chromo Shadow Domain Cooperate to Select Target Peptide Partners. [FBrf0213514]
Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593
Genome-Wide Analysis of Self-Renewal in Drosophila Neural Stem Cells by Transgenic RNAi. [FBrf0213621]
Pek and Kai, 2011, Curr. Biol. 21(1): 39--44
A role for vasa in regulating mitotic chromosome condensation in Drosophila. [FBrf0212718]
Reis et al., 2011, PLoS ONE 6(3): e17512
Drosophila Genes That Affect Meiosis Duration Are among the Meiosis Related Genes That Are More Often Found Duplicated. [FBrf0213266]
Riddle et al., 2011, Genome Res. 21(2): 147--163
Plasticity in patterns of histone modifications and chromosomal proteins in Drosophila heterochromatin. [FBrf0213099]
Seong et al., 2011, Cell 145(7): 1049--1061
Inheritance of Stress-Induced, ATF-2-Dependent Epigenetic Change. [FBrf0214019]
Yan et al., 2011, FASEB J. 25(1): 232--241
Unphosphorylated STAT and heterochromatin protect genome stability. [FBrf0212715]
Zhang et al., 2011, Chromosoma 120(1): 97--108
Drosophila melanogaster heterochromatin protein HP1b plays important roles in transcriptional activation and development. [FBrf0212898]
Apger et al., 2010, Genetics 185(4): 1151--1165
Multiple functions for Drosophila mcm10 suggested through analysis of two mcm10 mutant alleles. [FBrf0211525]
Bulchand et al., 2010, J. Cell Sci. 123(16): 2697--2707
Muscle wasted: a novel component of the Drosophila histone locus body required for muscle integrity. [FBrf0211459]
Dialynas et al., 2010, Development 137(18): 3067--3077
The role of Drosophila Lamin C in muscle function and gene expression. [FBrf0211601]
Dubruille et al., 2010, Curr. Biol. 20(23): 2090--2099
Specialization of a Drosophila Capping Protein Essential for the Protection of Sperm Telomeres. [FBrf0212516]
Emelyanov et al., 2010, J. Biol. Chem. 285(20): 15027--15037
Protein complex of Drosophila ATRX/XNP and HP1a is required for the formation of pericentric beta-heterochromatin in vivo. [FBrf0210725]
Filion et al., 2010, Cell 143(2): 212--224
Systematic protein location mapping reveals five principal chromatin types in Drosophila cells. [FBrf0212051]
Gan et al., 2010, Cell Res. 20(7): 763--783
Dynamic regulation of alternative splicing and chromatin structure in Drosophila gonads revealed by RNA-seq. [FBrf0211191]
Gao et al., 2010, EMBO J. 29(4): 819--829
HipHop interacts with HOAP and HP1 to protect Drosophila telomeres in a sequence-independent manner. [FBrf0210059]
Gou et al., 2010, PLoS ONE 5(5): e10581
SETDB1 Is Involved in Postembryonic DNA Methylation and Gene Silencing in Drosophila. [FBrf0210815]
Hofmann et al., 2010, Chromosome Res. 18(3): 307--324
The winged-helix transcription factor JUMU regulates development, nucleolus morphology and function, and chromatin organization of Drosophila melanogaster. [FBrf0210558]
Huang et al., 2010, J. Cell Sci. 123(16): 2853--2861
Drosophila CAF-1 regulates HP1-mediated epigenetic silencing and pericentric heterochromatin stability. [FBrf0211452]
Kim et al., 2010, Nat. Struct. Mol. Biol. 17(8): 1027--1029
Corecognition of DNA and a methylated histone tail by the MSL3 chromodomain. [FBrf0214093]
Kwon et al., 2010, Genes Dev. 24(19): 2133--2145
Heterochromatin protein 1 (HP1) connects the FACT histone chaperone complex to the phosphorylated CTD of RNA polymerase II. [FBrf0212000]
Lehmann et al., 2010, BMC Evol. Biol. 10: 156
Some novel intron positions in conserved Drosophila genes are caused by intron sliding or tandem duplication. [FBrf0211127]
modENCODE Consortium et al., 2010, Science 330(6012): 1787--1797
Identification of functional elements and regulatory circuits by Drosophila modENCODE. [FBrf0212741]
Moshkovich and Lei, 2010, PLoS Genet. 6(3): e1000880
HP1 Recruitment in the Absence of Argonaute Proteins in Drosophila. [FBrf0210291]
Prabhakaran and Kelley, 2010, BMC Biol. 8: 80
A new strategy for isolating genes controlling dosage compensation in Drosophila using a simple epigenetic mosaic eye phenotype. [FBrf0211122]
Raffa et al., 2010, Genes Dev. 24(15): 1596--1601
Verrocchio, a Drosophila OB fold-containing protein, is a component of the terminin telomere-capping complex. [FBrf0211409]
Schwaiger et al., 2010, Genome Res. 20(6): 771--780
Heterochromatin protein 1 (HP1) modulates replication timing of the Drosophila genome. [FBrf0210921]
Simmons et al., 2010, Genet. Res. (Camb.) 92(4): 261--272
Maternal impairment of transposon regulation in Drosophila melanogaster by mutations in the genes aubergine, piwi and Suppressor of variegation 205. [FBrf0212081]
Todeschini et al., 2010, PLoS ONE 5(6): e11032
The epigenetic trans-silencing effect in Drosophila involves maternally-transmitted small RNAs whose production depends on the piRNA pathway and HP1. [FBrf0211086]
van Steensel et al., 2010, Genome Res. 20(2): 190--200
Bayesian network analysis of targeting interactions in chromatin. [FBrf0209848]
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