FB2019_05, released Oct 15, 2019

Gene: Dmel\Su(var)205

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General Information
Symbol
Dmel\Su(var)205
Species
D. melanogaster
Name
Suppressor of variegation 205
Annotation Symbol
CG8409
Feature Type
protein_coding_gene
FlyBase ID
FBgn0003607
Gene Model Status
Current
Stock Availability
20 publicly available
Gene Snapshot
In progress.Contributions welcome.
Other Summaries
Also Known As
HP1, Su(var)2-5, HP1a, heterochromatin protein 1, HP-1
Key Links
Genomic Location
Cytogenetic map
28F2-28F3
Sequence location
2L:8,209,626..8,211,122 [-]
Recombination map
2-30
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
chromatin binding; protein binding; rDNA binding; RNA binding; satellite DNA binding
Predictions / Assertions
histone binding; methylated histone binding; mRNA binding
Summaries
Gene Group (FlyBase)
HETEROCHROMATIN PROTEIN 1 FAMILY -
Heterochromatin Protein 1 (HP1, Su(var)205) was first discovered in Drosophila as a dominant suppressor of position-effect variegation and a major component of heterochromatin. Members of the HP1 family are characterised by the presence of an N-terminal chromodomain and a C-terminal chromoshadow domain. In addition to heterochromatin packaging and silencing, HP1 proteins have diverse roles in the nucleus, including the regulation of euchromatic genes. (Adapted from FBrf0193304).
Protein Function (UniProtKB)
Structural component of heterochromatin, involved in gene repression and the modification of position-effect-variegation. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression.
(UniProt, P05205)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
Su(var)205
Encodes a nonhistone chromosomal protein, HP1, which by immunofluorescent staining of polytene chromosomes with a monoclonal antibody, is localized to α, β, and intercallary heterochromatin as well as chromosome 4 (James and Elgin, 1986, Mol. Cell. Biol. 6: 3862-72).
Summary (Interactive Fly)
chromodomain - Polycomb group - chromatin associated protein - required both for activation of heterochromatic genes and silencing of euchromatic genes
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\Su(var)205 or the JBrowse view of Dmel\Su(var)205 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.45
Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Su(var)205-RA
FBtr0079635
NM_057407
992
206
Su(var)205-RB
FBtr0079636
NM_164799
1109
206
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Su(var)205-PA
FBpp0079251
23.2
206
4.73
NP_476755
AAF52618
Su(var)205-PB
FBpp0079252
23.2
206
4.73
NP_723361
AAN11156
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

206 aa isoforms: Su(var)205-PA, Su(var)205-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
206 (aa)
(Eissenberg et al., 1990)
Comments
External Data
Subunit Structure (UniProtKB)
Homodimer; probably associates with Su(var)3-9. Interacts with Mcm10. Interacts (via chromoshadow domain) with piwi (via N-terminal region).
(UniProt, P05205)
Crossreferences
InterPro - A database of protein families, domains and functional sites
PDB - An information portal to biological macromolecular structures
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Su(var)205 using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Gene Ontology (42 terms)
Molecular Function (8 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
chromatin binding
inferred from mutant phenotype
(Johansson et al., 2007)
inferred from direct assay
(Sienski et al., 2015, Johansson et al., 2007)
protein binding
inferred from physical interaction with FLYBASE:ADD1; FB:FBgn0026573
(Alekseyenko et al., 2014)
inferred from physical interaction with FLYBASE:HIPP1; FB:FBgn0037027
(Alekseyenko et al., 2014)
inferred from physical interaction with UniProtKB:Q95RV2
(assigned by UniProt )
(Badugu et al., 2003)
inferred from physical interaction with FLYBASE:Su(var)3-7; FB:FBgn0003598
(Cleard et al., 1997)
rDNA binding
inferred from direct assay
(Blattes et al., 2006)
RNA binding
inferred from direct assay
(Alekseyenko et al., 2014)
satellite DNA binding
inferred from direct assay
(Blattes et al., 2006)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
histone binding
non-traceable author statement
(Kellum, 2003)
methylated histone binding
traceable author statement
(Simms et al., 2003)
mRNA binding
non-traceable author statement
(Kellum, 2003)
Biological Process (19 terms)
Terms Based on Experimental Evidence (17 terms)
CV Term
Evidence
References
chromatin silencing
inferred from high throughput mutant phenotype
(Donaldson et al., 2002)
chromatin silencing at centromere
inferred from high throughput mutant phenotype
(Donaldson et al., 2002)
chromosome organization
inferred from mutant phenotype
(Demakova et al., 2007)
establishment of chromatin silencing
inferred from mutant phenotype
(Seum et al., 2001)
gene silencing
inferred from direct assay
(Hines et al., 2009)
inferred from mutant phenotype
(Hines et al., 2009)
heterochromatin assembly
inferred from direct assay
(Hines et al., 2009)
heterochromatin organization involved in chromatin silencing
inferred from mutant phenotype
(Sienski et al., 2015)
histone H4-K20 trimethylation
inferred from mutant phenotype
(Yang et al., 2008)
mitotic cell cycle
inferred from direct assay
(assigned by CACAO )
(Dronamraju and Mason, 2011)
negative regulation of gene expression
inferred from direct assay
(Sienski et al., 2015)
inferred from genetic interaction with FLYBASE:egg; FB:FBgn0086908
(Sienski et al., 2015)
positive regulation of extent of heterochromatin assembly
inferred from mutant phenotype
(Hines et al., 2009)
positive regulation of histone H3-K9 dimethylation
inferred from direct assay
(Hines et al., 2009)
inferred from mutant phenotype
(Hines et al., 2009)
positive regulation of methylation-dependent chromatin silencing
inferred from mutant phenotype
(Yu et al., 2015)
regulation of apoptotic process
inferred from mutant phenotype
(Liu et al., 2005)
regulation of histone methylation
inferred from mutant phenotype
(Liu et al., 2005)
regulation of transcription, DNA-templated
inferred from mutant phenotype
(Liu et al., 2005)
telomere maintenance
inferred from mutant phenotype
(Perrini et al., 2004)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
negative regulation of transcription, DNA-templated
non-traceable author statement
(Kellum, 2003)
positive regulation of transcription, DNA-templated
traceable author statement
(Kellum, 2003)
Cellular Component (15 terms)
Terms Based on Experimental Evidence (14 terms)
CV Term
Evidence
References
chromosome
inferred from direct assay
(Koch et al., 2009)
chromosome, telomeric region
inferred from direct assay
(Dubruille et al., 2010, Gao et al., 2010)
condensed chromosome
inferred from direct assay
(Shaffer et al., 2006)
condensed nuclear chromosome, centromeric region
inferred from direct assay
(Blattes et al., 2006)
euchromatin
inferred from direct assay
(Hines et al., 2009)
heterochromatin
inferred from direct assay
(Shaffer et al., 2006)
nuclear heterochromatin
inferred from direct assay
(Shaffer et al., 2002)
nucleus
inferred from direct assay
(Sienski et al., 2015, Blattes et al., 2006, Cleard et al., 1997)
inferred from direct assay
(assigned by UniProt )
(Seller and O'Farrell, 2018)
pericentric heterochromatin
inferred from direct assay
(Alekseyenko et al., 2014)
polytene chromosome
inferred from direct assay
(Alekseyenko et al., 2014, Gause et al., 2008, Johansson et al., 2007)
polytene chromosome band
inferred from direct assay
(Seong et al., 2011)
polytene chromosome chromocenter
inferred from direct assay
(Seong et al., 2011, Hines et al., 2009, Font-Burgada et al., 2008, Fanti et al., 2003, Piacentini et al., 2003)
polytene chromosome puff
inferred from direct assay
(Fanti et al., 2003, Piacentini et al., 2003)
polytene chromosome, telomeric region
inferred from direct assay
(Hines et al., 2009, Fanti et al., 2003, Piacentini et al., 2003)
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
chromosome, centromeric region
traceable author statement
(Zhimulev and Belyaeva, 2003)
non-traceable author statement
(Kellum, 2003)
heterochromatin
traceable author statement
(Zhimulev and Belyaeva, 2003)
non-traceable author statement
(Kellum, 2003)
polytene chromosome chromocenter
traceable author statement
(Zhimulev and Belyaeva, 2003)
polytene chromosome puff
traceable author statement
(Kellum, 2003)
polytene chromosome, telomeric region
traceable author statement
(Zhimulev and Belyaeva, 2003)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | intense | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | intense | ubiquitous
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
organism | intense | ubiquitous
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 11 -- 12
anterior midgut primordium
(Fisher et al., 2012)
central brain primordium
(Fisher et al., 2012)
organism | intense | ubiquitous
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
posterior midgut primordium
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
embryonic central brain neuron
(Fisher et al., 2012)
embryonic/larval midgut
(Fisher et al., 2012)
embryonic/larval muscle system
(Fisher et al., 2012)
embryonic/larval nervous system
(Fisher et al., 2012)
gonad
(Fisher et al., 2012)
lateral cord neuron
(Fisher et al., 2012)
ventral nerve cord
(Fisher et al., 2012)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
(Eissenberg et al., 1990)
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage | male
organism
(Levine et al., 2012)
testis
(Levine et al., 2012)
adult stage | female
organism
(Levine et al., 2012)
ovary
(Levine et al., 2012)
adult stage
adult head
(Levine et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
larval stage
embryonic/larval salivary gland
(Cowell et al., 2002)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
Additional Descriptive Data
Analysis ofchromosome spreads of polytene salivary chromosomes shows that the Su(var)205 (HP1) protein localizes predominately to known heterochromatic regions and regions that are transcriptionally repressed such as band 31 on Chromosome 2L.
(Cowell et al., 2002)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
chromosome
inferred from direct assay
(Koch et al., 2009)
chromosome, telomeric region
inferred from direct assay
(Dubruille et al., 2010, Gao et al., 2010)
condensed chromosome
inferred from direct assay
(Shaffer et al., 2006)
condensed nuclear chromosome, centromeric region
inferred from direct assay
(Blattes et al., 2006)
euchromatin
inferred from direct assay
(Hines et al., 2009)
heterochromatin
inferred from direct assay
(Shaffer et al., 2006)
nuclear heterochromatin
inferred from direct assay
(Shaffer et al., 2002)
nucleus
inferred from direct assay
(Sienski et al., 2015, Blattes et al., 2006, Cleard et al., 1997)
inferred from direct assay
(assigned by UniProt )
(Seller and O'Farrell, 2018)
pericentric heterochromatin
inferred from direct assay
(Alekseyenko et al., 2014)
polytene chromosome
inferred from direct assay
(Alekseyenko et al., 2014, Gause et al., 2008, Johansson et al., 2007)
polytene chromosome band
inferred from direct assay
(Seong et al., 2011)
polytene chromosome chromocenter
inferred from direct assay
(Seong et al., 2011, Hines et al., 2009, Font-Burgada et al., 2008, Fanti et al., 2003, Piacentini et al., 2003)
polytene chromosome puff
inferred from direct assay
(Fanti et al., 2003, Piacentini et al., 2003)
polytene chromosome, telomeric region
inferred from direct assay
(Hines et al., 2009, Fanti et al., 2003, Piacentini et al., 2003)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Su(var)205 in GBrowse 2
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 20 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 67 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Su(var)205
Transgenic constructs containing regulatory region of Su(var)205
Deletions and Duplications ( 6 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal, with Scer\GAL4Act5C.PI
lethal (with Su(var)2052)
lethal (with Su(var)2054)
lethal | recessive
lethal - all die before end of embryonic stage | maternal effect | recessive
lethal - all die before end of pupal stage, with Scer\GAL4Act.PU
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4pnr-MD237
Sterility
Allele
female sterile, with Scer\GAL4nos.PG
Other Phenotypes
Allele
enhancer of variegation
enhancer of variegation, with Ab(2;3)Tell-P{Winkelried(-FRT)}
enhancer of variegation, with Ab(2;3)Tell-P{Winkelried}D
enhancer of variegation, with In(1)sc8
enhancer of variegation, with In(1)wm4
enhancer of variegation, with In(2)Heidi-P{Winkelried(-FRT)}
enhancer of variegation, with In(2)Heidi-P{Winkelried}D
enhancer of variegation, with P{Winkelried}A7
enhancer of variegation, with T(2;3)SbV
enhancer of variegation (with Su(var)2055), with ltunspecified
enhancer of variegation (with Su(var)205205), with ltunspecified
enhancer of variegation | dominant, with T(2;3)H33-6
enhancer of variegation | dominant, with T(2;3)H127-3
enhancer of variegation | dominant, with Tp(2;3)H76-7
flight defective, with Scer\GAL4Mef2.PR
increased cell death (with Su(var)2054)
increased cell death (with Su(var)2055)
neuroanatomy defective | larval stage
neuroanatomy defective | larval stage (with Su(var)2054)
neuroanatomy defective | larval stage (with Su(var)2055)
non-enhancer of variegation, with Dp(3;Y)BL2
non-enhancer of variegation, with In(1)wm4
non-enhancer of variegation, with In(1)wm4h
non-enhancer of variegation, with In(2)Heidi-P{Winkelried(-FRT)}
non-enhancer of variegation, with P{hsp26-pt-T}39C-5
non-enhancer of variegation, with P{hsp26-pt-T}39C-27
non-enhancer of variegation, with P{Winkelried(-FRT)}A7
non-enhancer of variegation, with P{Winkelried(-FRT)}A7, P{Winkelried}A7
non-suppressor of variegation, with P{hsp26-pt-T}39C-5
non-suppressor of variegation, with P{hsp26-pt-T}39C-27
non-suppressor of variegation, with P{RS5}5-HA-1005
non-suppressor of variegation | dominant, with P{hsp26-pt-T}8-M76
non-suppressor of variegation | dominant, with P{hsp26-pt-T}39C-5
non-suppressor of variegation | dominant, with P{RS5}5-HA-1902
non-suppressor of variegation | dominant, with P{RS5}5-HA-1992
short lived | heat sensitive, with Scer\GAL4tin.CΔ4
size defective | adult stage, with Scer\GAL4ey.PH
some die during embryonic stage | recessive | maternal effect | recessive
some die during pupal stage, with Scer\GAL4Act.PU
suppressor of variegation
suppressor of variegation, with Ab(2;3)Tell-P{Winkelried(-FRT)}
suppressor of variegation, with Ab(2;3)Tell-P{Winkelried}D
suppressor of variegation, with Byron
suppressor of variegation, with Dp(1;f)γ878
suppressor of variegation, with In(1)wm4
suppressor of variegation, with In(1)wm4h
suppressor of variegation, with In(2)Heidi-P{Winkelried(-FRT)}
suppressor of variegation, with In(2)Heidi-P{Winkelried}D
suppressor of variegation, with In(2R)bwVDe2
suppressor of variegation, with P{hsp26-pt-T}8-M11
suppressor of variegation, with P{hsp26-pt-T}8-M94
suppressor of variegation, with P{hsp26-pt-T}8-M175
suppressor of variegation, with P{hsp26-pt-T}8-M293
suppressor of variegation, with P{hsp26-pt-T}8-M318
suppressor of variegation, with P{hsp26-pt-T}39C-56
suppressor of variegation, with P{hsp26-pt-T}39C-68
suppressor of variegation, with P{hsp26-pt-T}39C-72
suppressor of variegation, with P{hsp26-pt-T}118E-10
suppressor of variegation, with P{hsp26-pt-T}CaMKII8-M1
suppressor of variegation, with P{hsp26-pt-T}CaMKII8-M262
suppressor of variegation, with P{hsp26-pt-T}Dyrk3118E-15
suppressor of variegation, with P{hsp26-pt-T}Dyrk3118E-15, T(2;4)X-2
suppressor of variegation, with P{hsp26-pt-T}Dyrk3118E-15, T(2;4)X-4
suppressor of variegation, with P{hsp26-pt-T}Dyrk3118E-15, Tp(4;3)X-10
suppressor of variegation, with P{hsp26-pt-T}HS-2
suppressor of variegation, with P{hsp26-pt-T}HS-4
suppressor of variegation, with P{hsp26-pt-T}HS-6
suppressor of variegation, with P{T1(-FRT)}T190-177
suppressor of variegation, with P{T1}T190-177
suppressor of variegation, with P{w+(FRT.attP.1360)}1198
suppressor of variegation, with P{wAR}41A
suppressor of variegation, with P{wAR}A
suppressor of variegation, with P{wAL}YAL
suppressor of variegation, with w+mW.hs
suppressor of variegation | dominant
suppressor of variegation | dominant, with dpyw18/dpyolv-12
suppressor of variegation | dominant, with In(1)wm4
suppressor of variegation | dominant, with In(1)wm4h
suppressor of variegation | dominant, with P{hsp26-pt-T}8-M76
suppressor of variegation | dominant, with P{hsp26-pt-T}39C-3
suppressor of variegation | dominant, with P{hsp26-pt-T}39C-12
suppressor of variegation | dominant, with P{hsp26-pt-T}39C-42
suppressor of variegation | dominant, with P{hsp26-pt-T}39C-66
suppressor of variegation | dominant, with P{hsp26-pt-T}118E-3
suppressor of variegation | dominant, with P{hsp26-pt-T}118E-10
suppressor of variegation | dominant, with P{hsp26-pt-T}118E-19
suppressor of variegation | dominant, with P{hsp26-pt-T}118E-25-5
suppressor of variegation | dominant, with P{hsp26-pt-T}ABCD39C-34
suppressor of variegation | dominant, with P{RS3}panCB-5204-3
suppressor of variegation | dominant, with P{SUPor-P}KV00108
suppressor of variegation | dominant, with P{SUPor-P}KV00135
suppressor of variegation | dominant, with P{SUPor-P}KV00590
suppressor of variegation | dominant, with T(2;3)SbV
suppressor of variegation | dominant, with T(2;3)V21-P{lacW}92E.x3
suppressor of variegation | recessive, with Dp(?;2)bwD
visible | adult stage, with Scer\GAL4en.PU
visible | adult stage, with Scer\GAL4ey.PH
visible | adult stage, with Scer\GAL4nub.PK
visible | adult stage, with Scer\GAL4nub.PU
wild-type
Phenotype manifest in
Allele
chromosome, telomeric region
chromosome, telomeric region (with Su(var)2054)
chromosome, telomeric region (with Su(var)2055)
embryonic/larval optic lobe
eye, with Scer\GAL4ey.PH
eye disc, with Scer\GAL4ey.PH
ganglion mother cell | larval stage
gastric caecum (with Su(var)2052)
gastric caecum (with Su(var)2055)
imaginal disc
imaginal disc (with Su(var)2054)
imaginal disc (with Su(var)2055)
larval neuroblast | larval stage
meiosis & nuclear chromosome | male
melanotic mass (with Df(2L)TE29Aa-11)
melanotic mass (with Su(var)2052)
melanotic mass (with Su(var)2054)
mitosis & chromosome, telomeric region
mitosis & nuclear chromosome (with Su(var)2054)
mitosis & nuclear chromosome (with Su(var)2055)
neuroblast, with Scer\GAL4Act.PU
neuroblast & larval brain
neuroblast | larval stage (with Su(var)2054)
neuroblast | larval stage (with Su(var)2055)
polytene chromosome
polytene chromosome (with Su(var)20503)
polytene chromosome (with Su(var)2054)
polytene chromosome (with Su(var)2055)
polytene chromosome | male (with Su(var)2054)
polytene chromosome | male (with Su(var)2055)
prothoracic gland | larval stage (with Su(var)2052)
prothoracic gland | larval stage (with Su(var)2055)
wing, with Scer\GAL4nub.PU
wing | posterior, with Scer\GAL4en-e16E
wing blade, with Scer\GAL4nub.PK
wing disc, with Scer\GAL4en-e16E
wing margin, with Scer\GAL4en.PU
wing margin, with Scer\GAL4nub.PK
wing posterior compartment, with Scer\GAL4en.PU
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (11)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\CBX1
9 of 15
Yes
No
 
Hsap\CBX3
8 of 15
No
No
 
Hsap\CBX5
6 of 15
No
No
 
 
Hsap\CBX7
1 of 15
No
No
Hsap\CDY1B
1 of 15
No
No
Hsap\CDY1
1 of 15
No
No
Hsap\CDY2A
1 of 15
No
No
Hsap\CDY2B
1 of 15
No
No
Hsap\CDYL2
1 of 15
No
No
Hsap\CDYL
1 of 15
No
No
Hsap\MPHOSPH8
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (7)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Cbx1
9 of 15
Yes
No
 
Mmus\Cbx5
6 of 15
No
No
Mmus\Cbx3
5 of 15
No
No
Mmus\Cbx7
1 of 15
No
No
Mmus\Cdyl2
1 of 15
No
No
Mmus\Cdyl
1 of 15
No
No
Mmus\Mphosph8
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (5)
Rnor\Cbx1
9 of 13
Yes
No
Rnor\Cbx3
7 of 13
No
Yes
Rnor\Cbx5
7 of 13
No
No
Rnor\Cdyl2
1 of 13
No
Yes
Rnor\Cdyl
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (4)
Xtro\cbx3
7 of 12
Yes
Yes
Xtro\cbx1
5 of 12
No
No
Xtro\cbx5
5 of 12
No
Yes
Xtro\LOC108646164
1 of 12
No
Yes
Danio rerio (Zebrafish) (6)
Drer\cbx1b
11 of 15
Yes
Yes
Drer\cbx1a
10 of 15
No
No
Drer\cbx5
8 of 15
No
Yes
Drer\cbx3a
7 of 15
No
No
Drer\cbx3b
6 of 15
No
Yes
Drer\cdyl
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (8)
Cele\hpl-1
12 of 15
Yes
Yes
Cele\hpl-2
5 of 15
No
No
Cele\cec-1
1 of 15
No
No
Cele\cec-3
1 of 15
No
Yes
Cele\cec-4
1 of 15
No
Yes
Cele\cec-6
1 of 15
No
Yes
Cele\cec-8
1 of 15
No
Yes
Cele\H04D03.6
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (1)
Atha\TFL2
1 of 9
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\NEW1
1 of 15
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (2)
Spom\chp2
5 of 12
Yes
Yes
Spom\swi6
4 of 12
No
No
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG09190HKT )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\Su(var)205
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00000402
Drosophila simulans
Dsim\HP1A
Drosophila sechellia
Dsec\HP1A
Drosophila erecta
Dere\HP1A
Drosophila yakuba
Dyak\HP1A
Drosophila ananassae
Dana\HP1A
Drosophila pseudoobscura pseudoobscura
Dpse\HP1A
Drosophila persimilis
Dper\HP1A
Drosophila willistoni
Dwil\HP1A
Drosophila virilis
Dvir\HP1A
Drosophila mojavensis
Dmoj\HP1A
Drosophila grimshawi
Dgri\HP1A
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150DRW )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17006185
Musca domestica
House fly
Mdoa\17023126
Musca domestica
House fly
Mdoa\17016428
Glossina morsitans
Tsetse fly
Gmor\GMOY008825
Glossina morsitans
Tsetse fly
Gmor\GMOY003696
Glossina morsitans
Tsetse fly
Gmor\GMOY004445
Glossina morsitans
Tsetse fly
Gmor\GMOY002752
Glossina morsitans
Tsetse fly
Gmor\GMOY006195
Glossina morsitans
Tsetse fly
Gmor\GMOY008893
Glossina morsitans
Tsetse fly
Gmor\GMOY004413
Glossina morsitans
Tsetse fly
Gmor\GMOY000491
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_13317
Mayetiola destructor
Hessian fly
Mdes\Mdes006245
Mayetiola destructor
Hessian fly
Mdes\Mdes019339
Mayetiola destructor
Hessian fly
Mdes\Mdes012494
Mayetiola destructor
Hessian fly
Mdes\Mdes011653
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL004467
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL004484
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL006720
Anopheles gambiae
Malaria mosquito
Agam\AGAP004723
Anopheles gambiae
Malaria mosquito
Agam\AGAP009444
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ017443
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ011888
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ007340
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ014352
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ001135
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ000743
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0K00 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA012860
Bombyx mori
Silkmoth
Bmor\BGIBMGA006109
Danaus plexippus
Monarch butterfly
Dple\DPOGS201860-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS206906-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL009415
Heliconius melpomene
Postman butterfly
Hmel\HMEL006992
Apis florea
Little honeybee
Aflo\2612080676
Apis mellifera
Western honey bee
Amel\LOC410395
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP19184
Bombus terrestris
Buff-tailed bumblebee
Bter\15213110
Linepithema humile
Argentine ant
Lhum\LH15287
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001b29
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG000123
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_03164
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_02006
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_02785
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_08612
Tribolium castaneum
Red flour beetle
Tcas\TC004466
Tribolium castaneum
Red flour beetle
Tcas\GLEAN_15268
Tribolium castaneum
Red flour beetle
Tcas\TC014676
Pediculus humanus
Human body louse
Phum\PHUM259320
Rhodnius prolixus
Kissing bug
Rpro\RPRC012579
Cimex lectularius
Bed bug
Clec\CLEC003559
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI000384
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI004446
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI009695
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI001318
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI000237
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_03086
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_07374
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_09985
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0K5Y )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR009102
Strigamia maritima
European centipede
Smar\SMAR005104
Ixodes scapularis
Black-legged tick
Isca\ISCW000122
Stegodyphus mimosarum
African social velvet spider
Smim\KFM79236.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM70668.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM64110.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM78112.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur04g08730
Tetranychus urticae
Two-spotted spider mite
Turt\tetur19g03120
Tetranychus urticae
Two-spotted spider mite
Turt\tetur26g00390
Tetranychus urticae
Two-spotted spider mite
Turt\tetur20g02700
Tetranychus urticae
Two-spotted spider mite
Turt\tetur11g03100
Tetranychus urticae
Two-spotted spider mite
Turt\tetur01g06110
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_318748
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_47532
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_9024
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_230770
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_239425
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_117481
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_57262
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_117706
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_239471
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_330083
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0RBS )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000022131
Gallus gallus
Domestic chicken
Ggal\CBX3
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000000230
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000027754
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (7)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
HP1b
6 of 10
HP1c
5 of 10
HP1e
5 of 10
HP6
4 of 10
Oxp
3 of 10
rhi
2 of 10
HP1Lcsd
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 2 )
    Allele
    Disease
    Interaction
    References
    Su(var)2055
    exacerbates  Alzheimer's disease
    modeled by Hsap\MAPTR406W.UAS
    (Frost et al., 2014)
    Su(var)205MB11439
    exacerbates  Alzheimer's disease
    modeled by Hsap\MAPTR406W.UAS
    (Frost et al., 2014)
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    CBX1; chromobox 1
    9 of 15
    604511
         
        CBX3; chromobox 3
        8 of 15
        604477
             
            CBX5; chromobox 5
            6 of 15
            604478
                 
                Functional Complementation Data
                Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                Dmel gene
                Ortholog showing functional complementation
                Supporting References
                Su(var)205
                Hsap\CBX5
                (Norwood et al., 2004)
                Interactions
                Summary of Physical Interactions
                esyN Network Diagram
                Show neighbor-neighbor interactions:
                Select Layout:
                Legend:
                Protein
                RNA
                Selected Interactor(s)
                Interactions Browser
                View in Interactions Browser
                Please see the Physical Interaction reports below for full details
                protein-protein
                Physical Interaction
                Assay
                References
                Su(var)205
                nuclear magnetic resonance, cosedimentation in solution, predetermined participant, molecular sieving, molecular weight, cosedimentation, x-ray crystallography, anti bait coimmunoprecipitation, western blot, pull down, anti tag western blot
                (Lee et al., 2019, Azzaz et al., 2014, Mendez et al., 2013, Mendez et al., 2011, Gou et al., 2010, Jacobs et al., 2001)
                Su(var)205 - ADD1
                anti tag coimmunoprecipitation, anti tag western blot, peptide massfingerprinting, western blot
                (Alekseyenko et al., 2014, López-Falcón et al., 2014)
                Su(var)205 - Acf
                pull down, autoradiography
                (Abel et al., 2009)
                Su(var)205 - Alh
                fluorescence polarization spectroscopy, predetermined participant
                (Mendez et al., 2011)
                Su(var)205 - Atf-2
                anti bait coimmunoprecipitation, western blot
                (Seong et al., 2011)
                Su(var)205 - Atg8a
                experimental knowledge based
                (Guruharsha et al., 2011)
                Su(var)205 - CAP
                anti tag coimmunoprecipitation, peptide massfingerprinting
                (Alekseyenko et al., 2014)
                Su(var)205 - CG11474
                experimental knowledge based
                (Guruharsha et al., 2011)
                Su(var)205 - CG15356
                fluorescence polarization spectroscopy, predetermined participant
                (Mendez et al., 2011)
                Su(var)205 - CG1737
                anti tag coimmunoprecipitation, peptide massfingerprinting
                (Alekseyenko et al., 2014)
                Su(var)205 - CG1815
                anti tag coimmunoprecipitation, peptide massfingerprinting
                (Alekseyenko et al., 2014)
                Su(var)205 - CG30403
                anti tag coimmunoprecipitation, peptide massfingerprinting
                (Alekseyenko et al., 2014)
                Su(var)205 - CG43736
                anti tag coimmunoprecipitation, peptide massfingerprinting
                (Alekseyenko et al., 2014)
                Su(var)205 - CG7692
                anti tag coimmunoprecipitation, peptide massfingerprinting
                (Alekseyenko et al., 2014)
                Su(var)205 - CG8108
                anti tag coimmunoprecipitation, peptide massfingerprinting
                (Alekseyenko et al., 2014)
                Su(var)205 - Caf1-180
                pull down, anti tag western blot, western blot, anti tag coimmunoprecipitation, peptide massfingerprinting, anti bait coimmunoprecipitation
                (Roelens et al., 2017, Alekseyenko et al., 2014, Huang et al., 2010)
                Su(var)205 - DNApol-ε255
                proximity ligation assay, fluorescence microscopy
                (Vo et al., 2017)
                Su(var)205 - Dp1
                anti tag coimmunoprecipitation, western blot, anti bait coimmunoprecipitation
                (Piacentini et al., 2009)
                Su(var)205 - E(bx)
                chromatography technology, western blot
                (Stephens et al., 2006)
                Su(var)205 - E(var)3-9
                anti tag coimmunoprecipitation, peptide massfingerprinting
                (Alekseyenko et al., 2014)
                Su(var)205 - E(z)
                anti bait coimmunoprecipitation, western blot
                (Cabrera et al., 2015)
                Su(var)205 - G9a
                pull down, anti tag western blot
                (Lee et al., 2019)
                Su(var)205 - Gnf1
                anti bait coimmunoprecipitation, western blot, proximity ligation assay, fluorescence microscopy
                (Vo et al., 2017)
                Su(var)205 - HIPP1
                anti tag coimmunoprecipitation, western blot, peptide massfingerprinting
                (Alekseyenko et al., 2014)
                Su(var)205 - HP1b
                anti bait coimmunoprecipitation, western blot, pull down, anti tag western blot, anti tag coimmunoprecipitation, peptide massfingerprinting
                (Lee et al., 2019, Alekseyenko et al., 2014)
                Su(var)205 - HP1c
                pull down, western blot, anti tag western blot
                (Lee et al., 2019, Kwon et al., 2010)
                Su(var)205 - HP4
                two hybrid, anti bait coimmunoprecipitation, western blot, phenotype-based detection assay, fluorescence microscopy, inferred by author, pull down, anti tag western blot
                (Hines et al., 2009, Schwendemann et al., 2008)
                Su(var)205 - HP5
                anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
                (Alekseyenko et al., 2014, Guruharsha et al., 2011)
                Su(var)205 - HP6
                anti bait coimmunoprecipitation, western blot, pull down, anti tag western blot
                (Joppich et al., 2009)
                Su(var)205 - Hers
                cosedimentation, western blot, anti bait coimmunoprecipitation
                (Ito et al., 2012)
                Su(var)205 - HipHop
                pull down, western blot, anti bait coimmunoprecipitation, chromatography technology, molecular sieving, molecular weight estimation by staining
                (Vedelek et al., 2015, Gao et al., 2010)
                Su(var)205 - His1
                pull down, western blot, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, anti tag western blot
                (Kavi et al., 2016, Lu et al., 2013)
                Su(var)205 - His2Av
                anti tag coimmunoprecipitation, western blot, pull down, anti tag western blot
                (Vernì and Cenci, 2015)
                Su(var)205 - His3
                pull down, western blot, fluorescence polarization spectroscopy, predetermined participant, nuclear magnetic resonance, genetic interference, autoradiography, isothermal titration calorimetry, anti tag western blot, far western blotting, molecular weight estimation by staining, surface plasmon resonance
                (Lee et al., 2019, Yu et al., 2015, Azzaz et al., 2014, Mohn et al., 2014, Coléno-Costes et al., 2012, Eisert and Waters, 2011, Kwon et al., 2010, Font-Burgada et al., 2008, Srinivasan et al., 2008, Jacobs and Khorasanizadeh, 2002, Jacobs et al., 2001)
                Su(var)205 - Hmr
                anti bait coimmunoprecipitation, western blot, anti tag western blot, anti tag coimmunoprecipitation, peptide massfingerprinting
                (Alekseyenko et al., 2014, Satyaki et al., 2014, Thomae et al., 2013)
                Su(var)205 - Hmt4-20
                phenotype-based detection assay, fluorescence microscopy, inferred by author
                (Hines et al., 2009)
                Su(var)205 - Hrb87F
                anti tag coimmunoprecipitation, western blot, anti bait coimmunoprecipitation
                (Tan et al., 2012, Piacentini et al., 2009)
                Su(var)205 - Hrb98DE
                anti tag coimmunoprecipitation, western blot
                (Tan et al., 2012)
                Su(var)205 - Incenp
                anti tag coimmunoprecipitation, peptide massfingerprinting
                (Alekseyenko et al., 2014)
                Su(var)205 - Jra
                anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Liu and Zhang, 2015)
                Su(var)205 - Kdm4A
                anti tag coimmunoprecipitation, anti tag western blot, molecular weight estimation by staining, western blot, peptide massfingerprinting
                (Alekseyenko et al., 2014, Lin et al., 2008)
                Su(var)205 - Lhr
                two hybrid, anti tag coimmunoprecipitation, western blot, anti bait coimmunoprecipitation, peptide massfingerprinting, anti tag western blot
                (Alekseyenko et al., 2014, Satyaki et al., 2014, Thomae et al., 2013, Brideau and Barbash, 2011, Brideau et al., 2006)
                Su(var)205 - MED17
                anti bait coimmunoprecipitation, western blot
                (Marr et al., 2014)
                Su(var)205 - MED26
                anti bait coimmunoprecipitation, western blot, affinity chromatography technology
                (Marr et al., 2014)
                Su(var)205 - Mau2
                anti tag coimmunoprecipitation, peptide massfingerprinting
                (Alekseyenko et al., 2014)
                Su(var)205 - Mcm10
                proximity ligation assay, fluorescence microscopy, anti bait coimmunoprecipitation, western blot, pull down, anti tag western blot, two hybrid
                (Vo et al., 2017, Apger et al., 2010)
                Su(var)205 - Mt2
                anti bait coimmunoprecipitation, western blot, pull down, autoradiography
                (Gou et al., 2010)
                Su(var)205 - NSD
                anti tag coimmunoprecipitation, peptide massfingerprinting
                (Alekseyenko et al., 2014)
                Su(var)205 - Nap1
                chromatography technology, western blot
                (Stephens et al., 2006)
                Su(var)205 - Ndc80
                anti tag coimmunoprecipitation, peptide massfingerprinting
                (Przewloka et al., 2007)
                Su(var)205 - Nipped-B
                anti tag coimmunoprecipitation, peptide massfingerprinting
                (Alekseyenko et al., 2014)
                Su(var)205 - Odj
                anti tag coimmunoprecipitation, peptide massfingerprinting, two hybrid, two hybrid array
                (Shokri et al., 2019, Alekseyenko et al., 2014, van Bemmel et al., 2013)
                Su(var)205 - Orc2
                anti bait coimmunoprecipitation, western blot
                (Pak et al., 1997)
                Su(var)205 - Orc5
                anti bait coimmunoprecipitation, western blot
                (Pak et al., 1997)
                Su(var)205 - Orc6
                anti bait coimmunoprecipitation, western blot
                (Pak et al., 1997)
                Su(var)205 - Pc
                anti bait coimmunoprecipitation, western blot
                (Cabrera et al., 2015)
                Su(var)205 - Pep
                anti tag coimmunoprecipitation, western blot, anti bait coimmunoprecipitation
                (Piacentini et al., 2009)
                Su(var)205 - RpII215
                anti bait coimmunoprecipitation, western blot, pull down, anti tag western blot, anti tag coimmunoprecipitation
                (Lee et al., 2019, Piacentini et al., 2009)
                Su(var)205 - Rrp6
                coimmunoprecipitation, anti tag western blot, anti tag coimmunoprecipitation, western blot
                (Eberle et al., 2015)
                Su(var)205 - SMC1
                anti tag coimmunoprecipitation, peptide massfingerprinting
                (Alekseyenko et al., 2014)
                Su(var)205 - SMC5
                anti tag coimmunoprecipitation, western blot
                (Chiolo et al., 2011)
                Su(var)205 - Sse
                anti tag coimmunoprecipitation, anti tag western blot, pull down, western blot
                (Cipressa et al., 2016)
                Su(var)205 - Ssrp
                pull down, western blot, anti bait coimmunoprecipitation, tandem affinity purification, multidimensional protein identification technology, anti tag western blot, anti tag coimmunoprecipitation
                (Lee et al., 2019, Kwon et al., 2010)
                Su(var)205 - Stat92E
                pull down, anti tag western blot, western blot, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
                (Xu et al., 2014, Shi et al., 2008)
                Su(var)205 - Su(var)2-10
                anti tag coimmunoprecipitation, peptide massfingerprinting
                (Alekseyenko et al., 2014)
                Su(var)205 - Su(var)2-HP2
                chromatography technology, western blot, anti bait coimmunoprecipitation, autoradiography, two hybrid, nuclear magnetic resonance, fluorescence polarization spectroscopy, predetermined participant, anti tag coimmunoprecipitation, peptide massfingerprinting, cosedimentation, molecular weight, molecular sieving
                (Alekseyenko et al., 2014, Mendez et al., 2013, Mendez et al., 2011, Gracheva et al., 2009, Stephens et al., 2006, Shaffer et al., 2002)
                Su(var)205 - Su(var)3-3
                anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, peptide massfingerprinting
                (Alekseyenko et al., 2014, Rudolph et al., 2007)
                Su(var)205 - Su(var)3-7
                anti bait coimmunoprecipitation, western blot, two hybrid
                (Delattre et al., 2000, Cleard et al., 1997)
                Su(var)205 - Su(var)3-9
                pull down, autoradiography, affinity chromatography technology, western blot, two hybrid, anti bait coimmunoprecipitation, anti tag western blot, anti tag coimmunoprecipitation, peptide massfingerprinting
                (Lee et al., 2019, Alekseyenko et al., 2014, Lu et al., 2013, Ito et al., 2012, Boeke et al., 2010, Abel et al., 2009, Schotta et al., 2002)
                Su(var)205 - Su(z)12
                anti bait coimmunoprecipitation, western blot
                (Cabrera et al., 2015)
                Su(var)205 - SuUR
                two hybrid, pull down, western blot, anti bait coimmunoprecipitation, Identification by mass spectrometry, anti tag coimmunoprecipitation, peptide massfingerprinting
                (Alekseyenko et al., 2014, Nordman et al., 2014, Pindyurin et al., 2008)
                Su(var)205 - Ubx
                bimolecular fluorescence complementation, fluorescence microscopy
                (Bischof et al., 2018)
                Su(var)205 - XNP
                anti tag coimmunoprecipitation, peptide massfingerprinting, anti tag western blot, enzymatic study, ion exchange chromatography, molecular sieving, anti bait coimmunoprecipitation, western blot, pull down, autoradiography
                (Alekseyenko et al., 2014, Emelyanov et al., 2010, Bassett et al., 2008)
                Su(var)205 - Yeti
                pull down, anti tag western blot
                (Messina et al., 2014)
                Su(var)205 - abd-A
                bimolecular fluorescence complementation, fluorescence microscopy
                (Bischof et al., 2018)
                Su(var)205 - bbx
                two hybrid array
                (Shokri et al., 2019)
                Su(var)205 - bon
                anti bait coimmunoprecipitation, western blot
                (Ito et al., 2012)
                Su(var)205 - borr
                anti tag coimmunoprecipitation, peptide massfingerprinting
                (Alekseyenko et al., 2014)
                Su(var)205 - cav
                pull down, anti tag western blot, anti tag coimmunoprecipitation, western blot, peptide massfingerprinting, chromatography technology, molecular sieving, molecular weight estimation by staining, two hybrid, anti bait coimmunoprecipitation, autoradiography
                (Cenci et al., 2015, Vedelek et al., 2015, Gao et al., 2010, Joppich et al., 2009, Raffa et al., 2009, Badugu et al., 2003, Shaffer et al., 2002, Shareef et al., 2001)
                Su(var)205 - dmt
                two hybrid, anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Yamada et al., 2017)
                Su(var)205 - dre4
                tandem affinity purification, multidimensional protein identification technology, western blot
                (Kwon et al., 2010)
                Su(var)205 - egg
                pull down, anti tag western blot, anti tag coimmunoprecipitation, peptide massfingerprinting, phenotype-based detection assay, fluorescence microscopy, inferred by author
                (Lee et al., 2019, Alekseyenko et al., 2014, Hines et al., 2009)
                Su(var)205 - eyg
                anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation
                (Salvany et al., 2012)
                Su(var)205 - fru
                anti bait coimmunoprecipitation, western blot
                (Ito et al., 2012)
                Su(var)205 - jnj
                anti tag coimmunoprecipitation, western blot
                (Chiolo et al., 2011)
                Su(var)205 - moi
                pull down, anti tag western blot
                (Raffa et al., 2009)
                Su(var)205 - mu2
                anti tag coimmunoprecipitation, western blot, two hybrid, anti bait coimmunoprecipitation, anti tag western blot, pull down
                (Dronamraju and Mason, 2011)
                Su(var)205 - ova
                anti tag coimmunoprecipitation, anti tag western blot, two hybrid
                (Yang et al., 2019)
                Su(var)205 - piwi
                nuclear magnetic resonance, anti bait coimmunoprecipitation, western blot, fluorescence polarization spectroscopy, predetermined participant, two hybrid, clip, reverse transcription pcr
                (Casale et al., 2019, Mendez et al., 2013, Mendez et al., 2011, Brower-Toland et al., 2007)
                Su(var)205 - qin
                anti tag coimmunoprecipitation, western blot, anti bait coimmunoprecipitation, anti tag western blot
                (Anand and Kai, 2012)
                Su(var)205 - rictor
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Su(var)205 - sle
                anti tag coimmunoprecipitation, peptide massfingerprinting
                (Alekseyenko et al., 2014)
                Su(var)205 - sov
                anti tag coimmunoprecipitation, peptide massfingerprinting, Identification by mass spectrometry
                (Jankovics et al., 2018, Alekseyenko et al., 2014)
                Su(var)205 - tea
                anti tag coimmunoprecipitation, peptide massfingerprinting
                (Alekseyenko et al., 2014)
                Su(var)205 - tj
                two hybrid array
                (Shokri et al., 2019)
                Su(var)205 - ver
                pull down, anti tag western blot
                (Raffa et al., 2010)
                Su(var)205 - vers
                anti tag coimmunoprecipitation, peptide massfingerprinting
                (Alekseyenko et al., 2014)
                Su(var)205 - vig
                anti bait coimmunoprecipitation, western blot
                (Gracheva et al., 2009)
                Su(var)205 - vig2
                anti bait coimmunoprecipitation, western blot
                (Gracheva et al., 2009)
                Su(var)205 - vtd
                anti tag coimmunoprecipitation, peptide massfingerprinting
                (Alekseyenko et al., 2014)
                Su(var)205 - woc
                fluorescence polarization spectroscopy, predetermined participant
                (Mendez et al., 2013)
                RNA-protein
                Physical Interaction
                Assay
                References
                Su(var)205 - Hsp70
                nucleic acid uv cross-linking assay, autoradiography, anti bait coimmunoprecipitation, primer extension assay, electrophoretic mobility shift assay
                (Piacentini et al., 2009)
                Su(var)205 - bam
                clip, reverse transcription pcr
                (Casale et al., 2019)
                Su(var)205 - cup
                clip, reverse transcription pcr
                (Casale et al., 2019)
                Su(var)205 - nos
                clip, reverse transcription pcr
                (Casale et al., 2019)
                Su(var)205 - piwi
                nuclear magnetic resonance, anti bait coimmunoprecipitation, western blot, fluorescence polarization spectroscopy, predetermined participant, two hybrid, clip, reverse transcription pcr
                (Casale et al., 2019, Mendez et al., 2013, Mendez et al., 2011, Brower-Toland et al., 2007)
                Summary of Genetic Interactions
                esyN Network Diagram
                esyN Network Key:
                Suppression
                Enhancement
                View in Interactions Browser
                Please look at the allele data for full details of the genetic interactions
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                Su(var)205|Sxl
                suppressible
                cav
                (Li et al., 2011)
                Su(var)205
                suppressible
                egg
                (Hines et al., 2009)
                Su(var)205
                suppressible
                fzy
                (Kuang et al., 2014)
                Su(var)205
                enhanceable
                htt
                (Dietz et al., 2015)
                Su(var)205
                suppressible
                htt
                (Dietz et al., 2015)
                w|Su(var)205
                enhanceable
                Su(var)3-9
                (Li et al., 2003)
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                ct|lncRNA:flam
                suppressible
                Su(var)205
                (Guida et al., 2016)
                Hers
                enhanceable
                Su(var)205
                (Ito et al., 2012)
                HP1b
                suppressible
                Su(var)205
                (Zhang et al., 2011)
                Lam
                suppressible
                Su(var)205
                (Chen et al., 2014)
                lt
                enhanceable
                E(Pc)|Su(var)205
                (Clegg et al., 1998)
                lt
                enhanceable
                Su(var)205|Su(var)208
                (Clegg et al., 1998)
                rl
                enhanceable
                Su(var)205
                (Lu et al., 2000)
                RpL15
                enhanceable
                Su(var)205
                (Schulze et al., 2005)
                RpL15|N
                enhanceable
                Su(var)205
                (Schulze et al., 2005)
                Sse
                suppressible
                Su(var)205
                (Cipressa et al., 2016)
                w
                suppressible
                Su(var)205
                (Ahmad and Golic, 1996)
                z
                suppressible
                Su(var)205
                (Judd, 1995)
                External Data
                Subunit Structure (UniProtKB)
                Homodimer; probably associates with Su(var)3-9. Interacts with Mcm10. Interacts (via chromoshadow domain) with piwi (via N-terminal region).
                (UniProt, P05205 )
                Linkouts
                BioGRID - A database of protein and genetic interactions.
                DroID - A comprehensive database of gene and protein interactions.
                InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                MIST (genetic) - An integrated Molecular Interaction Database
                MIST (protein-protein) - An integrated Molecular Interaction Database
                Pathways
                Gene Group - Pathway Membership (FlyBase)
                External Data
                Linkouts
                Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                SignaLink - A signaling pathway resource with multi-layered regulatory networks.
                Genomic Location and Detailed Mapping Data
                Chromosome (arm)
                2L
                Recombination map
                2-30
                Cytogenetic map
                28F2-28F3
                Sequence location
                2L:8,209,626..8,211,122 [-]
                FlyBase Computed Cytological Location
                Cytogenetic map
                Evidence for location
                28F2-28F3
                Limits computationally determined from genome sequence between P{lacW}l(2)k16919k16919&P{lacW}Bsgk09030 and P{lacW}Btk29Ak00206&P{EP}Btk29AEP715
                Experimentally Determined Cytological Location
                Cytogenetic map
                Notes
                References
                29A-29A
                (determined by in situ hybridisation)
                (Eissenberg et al., 1990, James and Elgin, 1986)
                28F2-29A1
                (Wustmann et al., 1989)
                Location based on deficiency mapping.
                (Wustmann et al., 1989)
                Experimentally Determined Recombination Data
                Location
                2-30
                (FlyBase, 2016)
                2-27.3
                (Comeron et al., 2012)
                2-28.9
                (Judd, 1995)
                2-31.1 +/- 3.1
                (Wustmann et al., 1989)
                2-24.7 +/- 1.3
                (Locke et al., 1988)
                2-28.9 +/- 2.0
                (Sinclair et al., 1983)
                2-31.1
                Left of (cM)
                Right of (cM)
                (Bushey and Locke, 2004)
                Notes
                Stocks and Reagents
                Stocks (20)
                Genomic Clones (20)
                cDNA Clones (60)
                 

                Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                cDNA clones, fully sequences
                BDGP DGC clones
                Other clones
                Drosophila Genomics Resource Center cDNA clones

                For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                cDNA Clones, End Sequenced (ESTs)
                BDGP DGC clones
                Other clones
                RNAi and Array Information
                Linkouts
                DRSC - Results frm RNAi screens
                GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                Antibody Information
                Laboratory Generated Antibodies
                 
                monoclonal
                (Lee et al., 2013, Chiolo et al., 2011)
                polyclonal
                (Gou et al., 2010, Font-Burgada et al., 2008)
                Commercially Available Antibodies
                 
                Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
                Other Information
                Relationship to Other Genes
                Source for database identify of
                Source for database merge of
                Additional comments
                Other Comments
                DNA-protein interactions: genome-wide binding profile assayed for Su(var)205 protein in Kc167 cells; see Chromatin_types_NKI collection report. Individual protein-binding experiments listed under "Samples" at GEO_GSE22069 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE22069).
                (Filion et al., 2010)
                Expression is enriched in embryonic gonads.
                (Shigenobu et al., 2006)
                The Su(var)205 protein modulates chromosomal integrity, histone modifications and transcription in a sex-specific manner.
                (Liu et al., 2005)
                The binding of Su(var)205 protein to many, but not all, target loci is dependent on Su(var)3-9.
                (Greil et al., 2003)
                Methyl-K9 His3 protein and Su(var)205 protein co-localise to the heterochromatic region of polytene chromosomes.
                (Jacobs et al., 2001)
                Su(var)205 may facilitate the coalescence of dispersed middle repetitive sequences, and organise the heterochromatic structure responsible for the variegated silencing of nearby euchromatic genes.
                (Seum et al., 2001)
                Su(var)205 is required for normal transcriptional activation of heterochromatic genes.
                (Lu et al., 2000)
                A consensus pentapeptide is sufficient for specific interaction with the Su(var)205 chromo shadow domain. Su(var)205 dimerisation occurs via pentapeptide binding.
                (Smothers and Henikoff, 2000)
                Mutations in Su(var)205 suppress telomeric Position Effect Variegation (PEV) on the fourth chromosome, but not the second and third chromosomes.
                (Cryderman et al., 1999)
                The Su(var)205 product, HP1, targets the chromatin of transposon insertions and binds more densely at a site with repeated sequences susceptible to heterochromatin formation. Sufficient density of Su(var)205 protein association is a necessary step in heterochromatin formation and gene silencing.
                (Fanti et al., 1998)
                Actr13E colocalises with Su(var)205 in the centric heterochromatin throughout prepupal development and the two proteins undergo a series of changes in nuclear distribution that coincide with major shifts in nuclear functions.
                (Frankel et al., 1997)
                Naturally occurring regulatory P-elements inserted at the telomere of the X chromosome have been isolated in a genomic context devoid of other P-elements. One or two copies of autonomous P-elements at this site (1A) are sufficient to elicit a strong P repression in the germline. Regulatory properties of the P-elements at 1A are strongly impaired by mutation of Su(var)205.
                (Ronsseray et al., 1997)
                The regulatory properties of P-elements at 1A are affected by mutants at Su(var)205.
                (Ronsseray et al., 1996)
                Su(var)205 protein contains a second chromo domain-like motif, the 'chromo shadow domain', in the C-terminal part of the protein.
                (Aasland and Stewart, 1995)
                Studies of the embryonic lethality of mutants demonstrates that in addition to its effect on position-effect variegation, Su(var)205 is also required for normal nuclear morphology and mitosis.
                (Kellum and Alberts, 1995)
                The intracellular localisation of Su(var)205 in the diploid nuclei of embryos before and after developmental changes that occur between cycles 10 and 14 is studied.
                (Kellum et al., 1995)
                Point mutations in the chromo domain of Su(var)205 abolish its ability to promote homeotic gene silencing. The chromo domain has chromosome binding activity. Pc also has a chromo domain, a chimeric Su(var)205-Pc protein (the chromo domain of Pc in the context of Su(var)205) causes mislocalisation of Su(var)205 to Pc binding sites and expression in transgenic flies promotes heterochromatin mediated gene silencing. Results support the view that the chromo domain homology reflects a common mechanistic basis for homeotic and heterochromatic silencing.
                (Platero et al., 1995)
                Su(var)205 is multiply phosphorylated in tissues, predominantly at Ser and Thr residues. Maternally synthesised Su(var)205 protein is under phosphorylated. At 1.5-2 hours of development, when cytologically visible heterochromatin appears, the more phosphorylated Su(var)205 isoforms appear. Results are consistent with a role for phosphorylation of Su(var)205 in the assembly and maintenance of heterochromatin.
                (Eissenberg et al., 1994)
                The presence of Su(var)205 does not have any discernible effect on wzm, wzl, wzvl, wzh or wcres, this was not checked in X/0 males.
                (Peterson et al., 1994)
                Heterochromatin-associated Su(var)205 gene product appears in euchromatic chromosomal regions that are inactivated as a result of position-effect variegation.
                (Belyaeva et al., 1993)
                Analysis of the subcellular localisation of Ecol\lacZ-Su(var)205 fusion proteins shows that amino acids 152-206 form the nuclear localisation domain and amino acids 95 to 206 form the heterochromatin binding domain of the Su(var)205 protein.
                (Powers and Eissenberg, 1993)
                Su(var)205 homologue has been cloned from D.virilis : a high degree of conservation in N- and C-terminal domains of the encoded DNA-binding protein "HP1" suggests that these domains could interact with other macromolecules in the formation of the condensed structure of heterochromatin.
                (Clark and Elgin, 1992)
                Su(var)205 gene product is an essential protein that functions as a part of an epigenetic mechanism capable of generating and maintaining an inactive chromatin structure.
                (Eissenberg et al., 1992)
                Alleles show additive effects with mod alleles on suppression of In(1)wm4 position effect variegation.
                (Garzino et al., 1992)
                Su(var)205 protein, detected by the C1A9 antibody in polytene chromosomes, is preferentially located in the beta-heterochromatin, the basal regions of the polytene chromosome arms and throughout chromosome 4.
                (James et al., 1989)
                Triplo-dependent enhancer of variegation.
                (Tartof et al., 1989)
                The variegation enhancer phenotype is due to increase in gene dosage: independently derived duplications of Su(var)205 act as enhancers and reversion of the dominant enhancer phenotype corresponds with the loss of the duplication.
                (Locke et al., 1988)
                triplo-enhancer; duplications for the locus cause enhancement of variegation (Tartof, Bishop, Jones, Hobbs and Locke, 1989).
                Encodes a nonhistone chromosomal protein, which by immunofluorescent staining of polytene chromosomes with a monoclonal antibody, is localized to α, β, and intercalary heterochromatin as well as chromosome 4 (FBrf0045031).
                Origin and Etymology
                Discoverer
                Etymology
                Identification
                External Crossreferences and Linkouts ( 55 )
                Sequence Crossreferences
                NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                Other crossreferences
                BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                Flygut - An atlas of the Drosophila adult midgut
                GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                InterPro - A database of protein families, domains and functional sites
                KEGG Genes - Molecular building blocks of life in the genomic space.
                modMine - A data warehouse for the modENCODE project
                PDB - An information portal to biological macromolecular structures
                Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                SignaLink - A signaling pathway resource with multi-layered regulatory networks.
                Linkouts
                BioGRID - A database of protein and genetic interactions.
                DPiM - Drosophila Protein interaction map
                DroID - A comprehensive database of gene and protein interactions.
                DRSC - Results frm RNAi screens
                Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
                FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                FlyMine - An integrated database for Drosophila genomics
                Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                MIST (genetic) - An integrated Molecular Interaction Database
                MIST (protein-protein) - An integrated Molecular Interaction Database
                Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                Synonyms and Secondary IDs (57)
                Reported As
                Symbol Synonym
                CBX5
                (Gieger et al., 2011)
                CG8409
                (Neuert et al., 2017, Çiçek et al., 2016, Hosono et al., 2015, Levine et al., 2012, Cammarato et al., 2011, Ni et al., 2011.7.19, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Pan and Zhang, 2009, Chen et al., 2008, Greil et al., 2007, Przewloka et al., 2007, Fakhouri et al., 2006)
                DmHP-1
                (Bertram and Pereira-Smith, 2001)
                DmHP1
                (Norwood et al., 2004)
                E(var)29
                (Tartof et al., 1989)
                E(var)29A
                FBgn0003607
                (Lehmann et al., 2010)
                HP-1
                (Henikoff, 2005, Balasov, 2002, Grewal and Elgin, 2002, Marhold et al., 2002, Lynn and Lloyd, 2001, Wakimoto, 1998, Marshall and Wilson, 1997, Shaffer et al., 1996, Marshall et al., 1995, Manak and Scott, 1994, Eissenberg et al., 1992, Clark and Elgin, 1991, Eissenberg et al., 1990, Eissenberg et al., 1990)
                HP1
                (Radion et al., 2019, Lee et al., 2018, Singh et al., 2018, Specchia et al., 2017, Cipressa et al., 2016, Derkacheva et al., 2016, Jiang et al., 2016, Kavi et al., 2016, L Black et al., 2016, Pindyurin and van Steensel, 2016.7.25, Dietz et al., 2015, Gandhi et al., 2015, Kavi et al., 2015, Meller et al., 2015, Pan et al., 2015, Pokholkova et al., 2015, Vedelek et al., 2015, Vernì and Cenci, 2015, Azzaz et al., 2014, Barton et al., 2014, Chen et al., 2014, Figueiredo et al., 2014, López-Falcón et al., 2014, Marr et al., 2014, Nordman et al., 2014, Oliveira et al., 2014, Ost et al., 2014, Xu et al., 2014, Zhang et al., 2014, Herzog et al., 2013, Le Thomas et al., 2013, Levine and Malik, 2013, Lu et al., 2013, Rohrbaugh et al., 2013, Salzler et al., 2013, Savva et al., 2013, Silver-Morse and Li, 2013, van Bemmel et al., 2013, Wood and Helfand, 2013, Anand and Kai, 2012, Bateman et al., 2012, Dubruille et al., 2012, Ito et al., 2012, Lakhotia et al., 2012, Larson et al., 2012, Loh et al., 2012, Maheshwari and Barbash, 2012, Maheshwari and Barbash, 2012, Singh and Lakhotia, 2012, Stern et al., 2012, Tan et al., 2012, Abramov et al., 2011, Brideau and Barbash, 2011, Burgio et al., 2011, Dufourt et al., 2011, Gibert and Karch, 2011, Klenov et al., 2011, Lee et al., 2011, Li et al., 2011, Olszak et al., 2011, Pane et al., 2011, Raffa et al., 2011, Seong et al., 2011, Shpiz et al., 2011, Yan et al., 2011, Apger et al., 2010, Biteau et al., 2010, Boeke et al., 2010, Bulchand et al., 2010, Chioda et al., 2010, Dialynas et al., 2010, Dubruille et al., 2010, Filion et al., 2010, Gao et al., 2010, Gurudatta et al., 2010, Hofmann et al., 2010, Huang et al., 2010, Kim et al., 2010, Lipsick, 2010.4.22, Moshkovich and Lei, 2010, Raffa et al., 2010, Reo et al., 2010, Schwaiger et al., 2010, Todeschini et al., 2010, van Steensel et al., 2010, Brower-Toland et al., 2009, Fagegaltier et al., 2009, Gracheva et al., 2009, Hines et al., 2009, Joppich et al., 2009, Kavi and Birchler, 2009, Klapholz et al., 2009, Koch et al., 2009, Komonyi et al., 2009, Lee et al., 2009, Lu et al., 2009, Nie et al., 2009, Raffa et al., 2009, Salvany et al., 2009, Schneiderman et al., 2009, Shevelyov et al., 2009, Vogel et al., 2009, Zhao et al., 2009, Brideau and Barbash, 2008, Chen et al., 2008, Cryderman et al., 2008, de Wit et al., 2008, Fanti et al., 2008, Frydrychova et al., 2008, Gause et al., 2008, Koch et al., 2008, Lloret-Llinares et al., 2008, Nisha et al., 2008, Pindyurin et al., 2008, Pinto et al., 2008, Remaud et al., 2008, Riddle et al., 2008, Scaria et al., 2008, Schwendemann et al., 2008, Sharakhov et al., 2008, Shi et al., 2008, Srinivasan et al., 2008, Sweeney et al., 2008, Wen et al., 2008, Yoon et al., 2008, Zhang et al., 2008, Bai et al., 2007, Brideau et al., 2007, Budde, 2007, Christensen et al., 2007, Cryderman et al., 2007, Cummings et al., 2007, Demakova et al., 2007, Deng et al., 2007, de Wit et al., 2007, Dronamraju and Mason, 2007, Goldberg et al., 2007, Greil et al., 2007, Grewal and Elgin, 2007, Johansson et al., 2007, Johansson et al., 2007, Josse et al., 2007, Klenov et al., 2007, Lee et al., 2007, Li et al., 2007, Minervini et al., 2007, Morris and Moazed, 2007, Nakayama et al., 2007, Nisha and Csink, 2007, Oikemus et al., 2007, Pathak et al., 2007, Peng and Karpen, 2007, Pindyurin et al., 2007, Ronsseray et al., 2007, Ronsseray et al., 2007, Sasai et al., 2007, Seum et al., 2007, Shi et al., 2007, Straub and Becker, 2007, Tzeng et al., 2007, Wagner et al., 2007, Yin and Lin, 2007, Zaratiegui, 2007, Zhimulev et al., 2007, Barbash et al., 2006, Birchler et al., 2006, Blattes et al., 2006, Brandt, 2006, Brandt et al., 2006, Brideau et al., 2006, Cavalli, 2006, Ciapponi et al., 2006, Deng et al., 2006, Deshpande et al., 2006, Eissenberg and Shilatifard, 2006, Haynes et al., 2006, Hediger and Gasser, 2006, Koryakov et al., 2006, Lomberk et al., 2006, Melcer and Gruenbaum, 2006, Oikemus et al., 2006, Orian, 2006, Peng and Karpen, 2006, Pickersgill et al., 2006, Shaffer et al., 2006, Shi et al., 2006, Stephens et al., 2006, Tolhuis et al., 2006, Varga-Weisz and Becker, 2006, Yasuhara and Wakimoto, 2006, Zhang et al., 2006, Adu-Wusu et al., 2005, Andreyeva et al., 2005, Badugu et al., 2005, Bi et al., 2005, Birchler et al., 2005, Carre et al., 2005, Cenci et al., 2005, Craig, 2005, Cryderman et al., 2005, de la Cruz et al., 2005, De Lucia et al., 2005, de Wit et al., 2005, Gvozdev et al., 2005, Hines et al., 2005, Ivanovska et al., 2005, Kamakaka and Biggins, 2005, Kavi et al., 2005, Liu et al., 2005, Louis and Vershinin, 2005, Nikolenko et al., 2005, Peng et al., 2005, Raffa et al., 2005, Schulze et al., 2005, Spierer et al., 2005, Stephens et al., 2005, Swaminathan et al., 2005, van Steensel et al., 2005, Vermaak et al., 2005, Wallace and Orr-Weaver, 2005, Wang et al., 2005, Ahmad, 2004, Brehm et al., 2004, Cao and Zhang, 2004, Ciapponi et al., 2004, Danzer and Wallrath, 2004, Delattre et al., 2004, Ebert et al., 2004, Huertas et al., 2004, Kosak and Groudine, 2004, Levine et al., 2004, Lippman and Martienssen, 2004, Lund and van Lohuizen, 2004, Oikemus et al., 2004, Pal-Bhadra et al., 2004, Perrini et al., 2004, Purdy and Su, 2004, Ronsseray et al., 2004, Sanchez-Elsner and Sauer, 2004, Schotta et al., 2004, Shaffer et al., 2004, Sun et al., 2004, Sural and Kuroda, 2004, Workman and Abmayr, 2004, Anonymous, 2003, Belyaeva et al., 2003, Berg et al., 2003, Biessmann and Mason, 2003, Boivin et al., 2003, Cenci et al., 2003, Cenci et al., 2003, Cortes et al., 2003, Cryderman et al., 2003, Danzer et al., 2003, Ebert et al., 2003, Fahrner and Baylin, 2003, Fanti et al., 2003, Fischle et al., 2003, Greil et al., 2003, Grewal and Moazed, 2003, Jaskelioff and Peterson, 2003, Josse et al., 2003, Kellum, 2003, Korge et al., 2003, Li et al., 2003, Li et al., 2003, McNairn and Gilbert, 2003, Min et al., 2003, Orlando, 2003, Piacentini et al., 2003, Salvaing et al., 2003, Shareef et al., 2003, Simms et al., 2003, Stephens et al., 2003, Sun et al., 2003, Zhimulev and Belyaeva, 2003, Badugu and Kellum, 2002, Cowell et al., 2002, Delattre et al., 2002, Dillon and Festenstein, 2002, Fourel et al., 2002, Gerbi and Bielinsky, 2002, Grade et al., 2002, Jacobs and Khorasanizadeh, 2002, Jaquet et al., 2002, Li et al., 2002, Li et al., 2002, Lynn et al., 2002, Neely and Workman, 2002, Richards and Elgin, 2002, Savitsky et al., 2002, Schotta et al., 2002, Shaffer, 2002.11.14, Shaffer et al., 2002, Siriaco et al., 2002, Ahmad and Henikoff, 2001, Barlow et al., 2001, Blower and Karpen, 2001, Danzer et al., 2001, Eissenberg, 2001, Eissenberg et al., 2001, Elgin et al., 2001, Hari et al., 2001, Hwang et al., 2001, Hwang et al., 2001, Jacobs et al., 2001, Jenuwein and Allis, 2001, Li et al., 2001, Linder et al., 2001, Ma et al., 2001, Martienssen, 2001, Moazed, 2001, Sanjuan and Marin, 2001, Seum et al., 2001, Seum et al., 2001, Shareef et al., 2001, Shareef et al., 2001, Van Steensel et al., 2001, van Steensel et al., 2001, van Steensel et al., 2001, Volpe et al., 2001, Wallrath et al., 2001, Zhang and Reinberg, 2001, Zhao et al., 2001, Anonymous, 2000, Birchler et al., 2000, Cenci et al., 2000, Cryderman et al., 2000, Delattre et al., 2000, Eissenberg and Elgin, 2000, Eissenberg and Hilliker, 2000, Gebuhr et al., 2000, Li et al., 2000, Naumova et al., 2000, Seum et al., 2000, Shaffer et al., 2000, Smothers and Henikoff, 2000, van Steensel and Henikoff, 2000, van Steensel and Henikoff, 2000, Wallrath, 2000, Wallrath et al., 2000, Zhao et al., 2000, Aasland, 1999, Aasland, 1999, Bernat et al., 1999, Cortes et al., 1999, Cryderman et al., 1999, Cryderman et al., 1999, Cryderman et al., 1999, Delattre et al., 1999, Dobie et al., 1999, Elgin et al., 1999, Kornberg and Lorch, 1999, Schotta et al., 1999, Siriaco et al., 1999, Sun et al., 1999, Zhao and Eissenberg, 1999, Anonymous, 1998, Cavalli and Paro, 1998, Elgin et al., 1998, Fanti et al., 1998, Fanti et al., 1998, Gregory and Horz, 1998, Huang et al., 1998, Lu and Eissenberg, 1998, Nelson et al., 1998, Platero et al., 1998, Singh and Huskisson, 1998, Sun et al., 1998, Wallrath, 1998, Wallrath et al., 1998, Belyaeva et al., 1997, Cleard et al., 1997, Elgin et al., 1997, Frankel et al., 1997, Goldman, 1997, Hilfiker et al., 1997, Huang and Kellum, 1997, Nelson and Tomkiel, 1997, Pak et al., 1997, Pirrotta, 1997, Platero et al., 1997, Wakimoto, 1997, Wilkins and Lis, 1997, Zuckerkandl, 1997, Balasov and Makunin, 1996, Huang and Kellum, 1996, Platero et al., 1996, Svaren and Hoerz, 1996, Aasland and Stewart, 1995, Kellum and Alberts, 1995, Kellum et al., 1995, Koonin et al., 1995, Ngan et al., 1995, Platero et al., 1995, Becker, 1994, Carlson and Laurent, 1994, Eissenberg et al., 1994, Elgin et al., 1994, Kellum and Alberts, 1994, Belyaeva et al., 1993, Eissenberg and Hartnett, 1993, Kellum and Alberts, 1993, Powers and Eissenberg, 1993, Saunders et al., 1993, Shaffer et al., 1993, Epstein et al., 1992, Singh et al., 1991, Elgin, 1990, James et al., 1989)
                HP1-VS
                (Ngan, 1995.9.21)
                HP1A
                (Beck and Llopart, 2015, Levine and Malik, 2013, Levine et al., 2012, Levine et al., 2012, Hiatt et al., 2007, Vermaak et al., 2005)
                HP1a
                (Gervais et al., 2019, Lee et al., 2019, Park et al., 2019, Seller et al., 2019, Sidorenko et al., 2019, Yang et al., 2019, Akulenko et al., 2018, Caridi et al., 2018, Clémot et al., 2018, Jankovics et al., 2018, Penke et al., 2018, Rosin et al., 2018, Šatović et al., 2018, Seller and O'Farrell, 2018, Warecki and Sullivan, 2018, Amaral et al., 2017, Caridi et al., 2017, Chavez et al., 2017, Colmenares et al., 2017, Gerland et al., 2017, Hyun, 2017, Marshall and Brand, 2017, Roelens et al., 2017, Strom et al., 2017, Tsurumi et al., 2017, Vo et al., 2017, Yamada et al., 2017, Yang and Xi, 2017, Bayona-Feliu et al., 2016, Boija and Mannervik, 2015, Eberle et al., 2015, Liu and Zhang, 2015, Ryu et al., 2015, Sienski et al., 2015, Yu et al., 2015, Alekseyenko et al., 2014, Alekseyenko et al., 2014, Comoglio and Paro, 2014, Eissenberg and Elgin, 2014, Messina et al., 2014, Pascual-Garcia et al., 2014, Ross et al., 2014, Satyaki et al., 2014, Crona et al., 2013, Huang et al., 2013, Lundberg et al., 2013, Ohtani et al., 2013, Thomae et al., 2013, Yamamoto and Koganezawa, 2013, Dialynas et al., 2012, Dubruille et al., 2012, Figueiredo et al., 2012, Ito et al., 2012, Joyce et al., 2012, Lin et al., 2012, Riddle et al., 2012, Sakoparnig et al., 2012, Salvany et al., 2012, Sentmanat and Elgin, 2012, Cryderman et al., 2011, Demakov et al., 2011, Kharchenko et al., 2011, Kwon and Workman, 2011, Kwon and Workman, 2011, Li et al., 2011, Mendez et al., 2011, Pek and Kai, 2011, Wang and Elgin, 2011, Yin et al., 2011, Zhang et al., 2011, Chioda et al., 2010, Emelyanov et al., 2010, Kwon et al., 2010, modENCODE Consortium et al., 2010, Abel et al., 2009, Lau et al., 2009, Pek et al., 2009, Piacentini et al., 2009, Schulze et al., 2009, Doheny et al., 2008, Lin et al., 2008, Brower-Toland et al., 2007, Przewloka et al., 2007, Moorman et al., 2006, Moorman et al., 2006, Talbert and Henikoff, 2006, Yasuhara and Wakimoto, 2006, Liu et al., 2005, Osouda et al., 2005, Badugu et al., 2003, Smothers and Henikoff, 2001)
                HP1α
                (Warecki and Sullivan, 2018, Yu et al., 2015, Frost et al., 2014, Eisert and Waters, 2011, Straub et al., 2005, Cao et al., 2002)
                Hp1
                (Petruk et al., 2013, Chmielewski et al., 2012, Ferree and Prasad, 2012, Apger et al., 2010, Shermoen et al., 2010, Su, 2010, Plata et al., 2009, Christensen and Tye, 2003, Shannon and Rao, 2002)
                Hp1a
                (Ren et al., 2014, Doheny et al., 2008)
                SU(VAR)205
                (Ho et al., 2014, Lau et al., 2009)
                Su(Var)2-5
                (Naumova et al., 1999)
                Su(Var)205
                (Cenci et al., 2015)
                Su(var)
                (Dunn et al., 2001)
                Su(var)2-05
                (Demakova et al., 1998)
                Su(var)2-5
                (Chang et al., 2019, Glenn and Geyer, 2019, Park et al., 2019, Derkacheva et al., 2016, Hong and Choi, 2016, Timms et al., 2016, Crona et al., 2013, Elgin and Reuter, 2013, Silva-Sousa and Casacuberta, 2013, Vasanthi et al., 2013, Abramov et al., 2011, Batlle et al., 2011, Cryderman et al., 2011, Wang et al., 2011, Yan et al., 2011, Emelyanov et al., 2010, Hofmann et al., 2010, Kwon et al., 2010, Moshkovich and Lei, 2010, Prabhakaran and Kelley, 2010, Todeschini et al., 2010, Hines et al., 2009, Joppich et al., 2009, Lu et al., 2009, Phalke et al., 2009, Piacentini et al., 2009, Schulze et al., 2009, Doheny et al., 2008, Gause et al., 2008, Lin et al., 2008, Pindyurin et al., 2008, Riddle et al., 2008, Schwendemann et al., 2008, Yang et al., 2008, Andreyeva et al., 2007, Brower-Toland et al., 2007, Demakova et al., 2007, Deng et al., 2007, Haigh and Lloyd, 2007, Rudolph et al., 2007, Shpiz et al., 2007, Eissenberg and Shilatifard, 2006, Koryakov et al., 2006, Lomberk et al., 2006, Cenci et al., 2005, Cryderman et al., 2005, Dimitri et al., 2005, Lam et al., 2005, Schulze et al., 2005, Spierer et al., 2005, Swaminathan et al., 2005, Bazin et al., 2004, Cenci et al., 2004, Ebert et al., 2004, Norwood et al., 2004, Segal et al., 2004, Sun et al., 2004, Belyaeva et al., 2003, Cenci et al., 2003, Cenci et al., 2003, Erhardt et al., 2003, Fahrner and Baylin, 2003, Fanti et al., 2003, Kelley and Kuroda, 2003, Li et al., 2003, Perrod and Gasser, 2003, Yoo et al., 2003, Zhimulev and Belyaeva, 2003, Balasov, 2002, Bernard and Allshire, 2002, Blower and Karpen, 2002, Cenci et al., 2002, Delattre et al., 2002, Donaldson et al., 2002, Georgiev et al., 2002, Grewal and Elgin, 2002, Joanis and Lloyd, 2002, Li et al., 2002, Richards and Elgin, 2002, Savitsky et al., 2002, Schotta et al., 2002, Westphal and Reuter, 2002, Blower and Karpen, 2001, Choo, 2001, Gasser, 2001, Hwang et al., 2001, Jenuwein and Allis, 2001, Ma et al., 2001, Seum et al., 2001, Sun et al., 2001, Yoo et al., 2001, Balasov et al., 2000, Balasov et al., 2000, Eissenberg and Elgin, 2000, Eissenberg and Hilliker, 2000, Gebuhr et al., 2000, Gvozdev et al., 2000, Lu et al., 2000, McKee et al., 2000, Naumova et al., 2000, Seum et al., 2000, Sun et al., 2000, Cryderman et al., 1999, Cryderman et al., 1999, Delattre et al., 1999, Sun et al., 1999, Cavalli and Paro, 1998, Cryderman et al., 1998, Fanti et al., 1998, Sass and Henikoff, 1998, Cleard and Spierer, 1997, Cleard et al., 1997, Dorn et al., 1993, Eissenberg et al., 1990)
                Su(var)2-501
                (Netter et al., 1998)
                Su(var)205
                (Martins et al., 2019, Shimaji et al., 2019, Shokri et al., 2019, Bischof et al., 2018, Hughes et al., 2018, Jankovics et al., 2018, Levis, 2018.8.30, Markmiller et al., 2018, Masuko et al., 2018, Warecki and Sullivan, 2018, Amaral et al., 2017, Caridi et al., 2017, Kurzhals et al., 2017, Marie et al., 2017, Neuert et al., 2017, Roelens et al., 2017, Teixeira et al., 2017, Transgenic RNAi Project members, 2017-, Cipressa et al., 2016, Clandinin and Owens, 2016-, Guida et al., 2016, Jiang et al., 2016, Dietz et al., 2015, Dubruille and Loppin, 2015, Kim et al., 2015, Nikalayevich and Ohkura, 2015, Sienski et al., 2015, Aldrich and Maggert, 2014, Frost et al., 2014, Gonzalez et al., 2014, Kim and Choe, 2014, Kuang et al., 2014, Wang et al., 2014, Yan et al., 2014, Czech et al., 2013, Kwon et al., 2013, Mason, 2013.1.25, Moshkin et al., 2013, Raffa et al., 2013, Rohrbaugh et al., 2013, Sentmanat et al., 2013, Silver-Morse and Li, 2013, Vaque et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Larson et al., 2012, Riddle et al., 2012, Salvany et al., 2012, Sentmanat and Elgin, 2012, Simmons et al., 2012, Dufourt et al., 2011, Friedman et al., 2011, Gieger et al., 2011, Kurzhals et al., 2011, Li et al., 2011, Neumüller et al., 2011, Raffa et al., 2011, Reis et al., 2011, Yan et al., 2011, Chioda et al., 2010, Dubruille et al., 2010, Gan et al., 2010, Gou et al., 2010, Gurudatta et al., 2010, Kallappagoudar et al., 2010, Raffa et al., 2010, Simmons et al., 2010, Todeschini et al., 2010, Anderson et al., 2009, Belinco et al., 2009, Chen et al., 2008, Frydrychova et al., 2008, Kent, 2008, Musarò et al., 2008, Nisha et al., 2008, Ronsseray et al., 2008, Shi et al., 2008, Haigh and Lloyd, 2007, Josse et al., 2007, Prasad and Mason, 2007, Ronsseray et al., 2007, Xing et al., 2007, Minakhina and Steward, 2006, Shi et al., 2006, Shigenobu et al., 2006, Yasuhara and Wakimoto, 2006, Andreyeva et al., 2005, Bi et al., 2005, Kalmykova et al., 2005, Liu et al., 2005, Le et al., 2004, Gim et al., 2001, Linder et al., 2001)
                Su(var)29A
                (Locke et al., 1988)
                Su(var)205
                (Morcillo and MacIntyre, 2001, Gonzalez and Bornens, 2000)
                Su-var(2)5
                (Wustmann et al., 1989)
                SuVar205
                (Vermaak et al., 2005)
                Suvar205
                (Cummings et al., 2007)
                Sur(var)205
                (Gao et al., 2019)
                Suvar(2)5
                (Singh and Huskisson, 1998, Sigrist and Pirrotta, 1997, Henikoff, 1996, Reuter and Spierer, 1992, Spradling and Karpen, 1990)
                Suvar2-5
                (Kellum and Alberts, 1995)
                dHP-1a
                (Bassett et al., 2008)
                dHP1
                (Eisert et al., 2015, Wisniewski et al., 1999)
                dHP1a
                (Kato et al., 2007)
                hp1
                (Théron et al., 2018, Rong, 2008)
                hp1a
                (Bayona-Feliu et al., 2017, Eberle et al., 2015, Lavrenov et al., 2014, Font-Burgada et al., 2008)
                su(var)205
                (Lo et al., 2016, Zhang et al., 2014, Gao et al., 2010, Minakhina et al., 2007, McVean and Vieira, 1999)
                Name Synonyms
                C1A9-nuclear-antigen
                Heterochromatic Protein 1
                (Vedelek et al., 2015)
                Heterochromatic Protein 1a
                (Doheny et al., 2008)
                Heterochromatin Protein 1
                (Biteau et al., 2010, Moshkovich and Lei, 2010, Fagegaltier et al., 2009, Hines et al., 2009, Piacentini et al., 2009, Vogel et al., 2009, Cryderman et al., 2008, Remaud et al., 2008, Zhang et al., 2008, Josse et al., 2007, Peng and Karpen, 2006, Fanti et al., 2003, Hari et al., 2001)
                Heterochromatin Protein 1A
                (Hiatt et al., 2007)
                Heterochromatin Protein 1a
                (Pek et al., 2009, Moorman et al., 2006)
                Heterochromatin protein 1
                (Schwaiger et al., 2010, Chen et al., 2008, de Wit et al., 2007, Brandt et al., 2006, Melcer and Gruenbaum, 2006, Cryderman et al., 2005, de Wit et al., 2005)
                Heterochromatin protein 1A
                (Levine et al., 2012)
                Heterochromatin protein-1
                (Kavi and Birchler, 2009)
                Histone Protein 1
                (Barbash et al., 2006)
                Su(var)2-5
                (Badugu et al., 2005)
                Su(var)205
                Suppressor of variegation 205
                (Comoglio and Paro, 2014, Cammarato et al., 2011, Lau et al., 2009, Xing et al., 2007, Gim et al., 2001)
                heterochromatic protein
                (Gvozdev et al., 2005)
                heterochromatin factor 1
                (Kavi et al., 2015)
                heterochromatin protein 1
                (Kavi et al., 2016, Marr et al., 2014, Zhang et al., 2014, Silver-Morse and Li, 2013, Wood and Helfand, 2013, Tan et al., 2012, Li et al., 2011, Olszak et al., 2011, Bulchand et al., 2010, van Steensel et al., 2010, Koch et al., 2009, Schneiderman et al., 2009, Koch et al., 2008, Scaria et al., 2008, Shi et al., 2008, Johansson et al., 2007, Shi et al., 2007, Birchler et al., 2005, Liu et al., 2005, Vermaak et al., 2005, Sun et al., 2004, Fischle et al., 2003, Kellum, 2003, Balasov, 2002, Linder et al., 2001, Cryderman et al., 2000)
                heterochromatin protein 1a
                (Dubruille et al., 2012, Mendez et al., 2011, Lau et al., 2009)
                heterochromatin protein-1
                (Lee et al., 2011, Yoon et al., 2008)
                heterochromatin-binding protein
                (Dillon and Festenstein, 2002)
                heterochromatin-protein-1
                (Yoon et al., 2008, Eissenberg and Hartnett, 1993, Eissenberg et al., 1992)
                suppressor of variegated 205
                (Kuang et al., 2014)
                suppressor of variegation 205
                (Sen and Cox, 2016)
                Secondary FlyBase IDs
                  Datasets (4)
                  Study focus (4)
                  Experimental Role
                  Project
                  Project Type
                  Title
                  • transgene_used
                  FBGSE22069
                  Protein profiling reveals five principal chromatin types in Drosophila cells.
                  • RNAi_target
                  modENCODE_chromatin_proteins_cells
                  Genome-wide localization of chromosomal proteins in cell lines by ChIP-chip and ChIP-Seq.
                  • allele_used
                  modENCODE_chromatin_proteins_flies
                  Genome-wide localization of chromosomal proteins in fly tissues by ChIP-chip and ChIP-Seq.
                  • allele_used
                  modENCODE_chromatin_histones_flies
                  Genome-wide localization of histones and their modifications in fly tissues by ChIP-chip and ChIP-Seq.
                  References (827)