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General Information
Symbol
Dmel\svp
Species
D. melanogaster
Name
seven up
Annotation Symbol
CG11502
Feature Type
FlyBase ID
FBgn0003651
Gene Model Status
Stock Availability
Gene Snapshot
In progress.Contributions welcome.
Also Known As

ck16, NR2F3, l(3)ck16, don, SVP1

Key Links
Genomic Location
Cytogenetic map
Sequence location
3R:12,258,737..12,302,785 [+]
Recombination map

3-52

RefSeq locus
NT_033777 REGION:12258737..12302785
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Protein Family (UniProt)
Belongs to the nuclear hormone receptor family. NR2 subfamily. (P16375P16376)
Summaries
Gene Group (FlyBase)
NUCLEAR RECEPTOR (LIGAND-DEPENDENT) TRANSCRIPTION FACTORS -
Nuclear receptors (NR) are C4 zinc finger ligand-dependent DNA-binding transcription factors. Members of the NR superfamily are defined by the presence of a highly conserved DNA-binding domain and a less conserved C-terminal ligand-binding domain. (Adapted from FBrf0184203).
Protein Function (UniProtKB)
Receptor that is required in photoreceptors R1, R3, R4 and R6 during eye development; generation of the ganglion mother cell-2 (GMC-2) fate in the nb7-3 lineage, coinciding with the transition in the expression of HB to KR in the neuroblasts (NBs).
(UniProt, P16375P16376)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
svp: seven up (Y. Hiromi)
Originally identified as recessive lethal mutations; independently identified by an enhancer-trap screen to be a gene expressed in a subset of neuroblasts in the embryonic CNS and also in a subset of photoreceptor-cell precursors in the developing compound eye. Mutant alleles die as embryos with normal cuticular morphology, but have alterations in numbers of eve-positive neurons in some neuroblast lineages. svp- clones in the eye produce abnormal ommatidia where photoreceptors R1, R3, R4, and R6 are transformed toward another photoreceptor R7. In addition, svp- ommatidia usually contain one to two extra photoreceptor cells. Mosaic studies show that transformation towards R7 is due to cell autonomous requirement in R1, R3, R4, and R6, whereas production of extra cell(s) is a secondary phenotype caused by lack of svp+ function in other cells, most likely in R3 and R4. Formation of some, but not all, R7-like cells in svp- ommatidia is dependent on sev+ function.
Summary (Interactive Fly)

transcription factor - orphan nuclear receptor - zinc finger - required for development of four of the eight photoreceptors that develop in each ommatidium of the eye, the R3/R4 pair and the R1/R6 pair - Stem cell-intrinsic, triggers temporal factor gradients that diversify intermediate neural progenitors in the larval brain

Gene Model and Products
Number of Transcripts
5
Number of Unique Polypeptides
5

Please see the GBrowse view of Dmel\svp or the JBrowse view of Dmel\svp for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.44

Stop-codon suppression (UGA) postulated; FBrf0216884.

gene_with_stop_codon_read_through ; SO:0000697

Gene model reviewed during 5.47

Double stop-codon suppression (UGA, UGA) postulated; FBrf0243886.

Gene model reviewed during 6.32

Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0082563
3421
746
FBtr0082564
3859
543
FBtr0082562
2876
281
FBtr0331183
3859
554
FBtr0479795
3859
826
Additional Transcript Data and Comments
Reported size (kB)

1.7 (unknown)

Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0082035
76.8
746
7.92
FBpp0082036
58.0
543
8.25
FBpp0082034
31.3
281
7.14
FBpp0303610
59.3
554
8.33
FBpp0428128
85.3
826
7.90
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)

746, 543 (aa)

Comments
External Data
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\svp using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (29 terms)
Molecular Function (9 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000638895
(assigned by GO_Central )
non-traceable author statement
inferred from biological aspect of ancestor with PANTHER:PTN000638895
(assigned by GO_Central )
inferred from electronic annotation with InterPro:IPR001723
(assigned by InterPro )
inferred from electronic annotation with InterPro:IPR001628, InterPro:IPR013088
(assigned by InterPro )
Biological Process (18 terms)
Terms Based on Experimental Evidence (11 terms)
CV Term
Evidence
References
inferred from expression pattern
inferred from genetic interaction with FLYBASE:tin; FB:FBgn0004110
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from high throughput mutant phenotype
Terms Based on Predictions or Assertions (8 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000638895
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000638895
(assigned by GO_Central )
traceable author statement
traceable author statement
inferred from biological aspect of ancestor with PANTHER:PTN000638895
(assigned by GO_Central )
Cellular Component (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
inferred from direct assay
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000638895
(assigned by GO_Central )
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
distribution deduced from reporter (Gal4 UAS)
Stage
Tissue/Position (including subcellular localization)
Reference
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
organism

Comment: maternally deposited

Additional Descriptive Data

Expression of svp is observed in the two anterior-most pairs of cardioblasts in abdominal hemisegments.

svp transcript is detected in the Pp3 neuroblast group (also known as Ppd15, Ppd16, Ppd18 and Ppd20).

svp expression is similar to that seen in the AE127 svp-lacZ line. Expression is observed from embryonic stage 11 in some of the heart progenitor cells. svp is later expressed in cardioblasts in a pattern complementary to the tin pattern in that the two pairs of svp-expressing cardioblasts do not express tin. Expression is also observed in the corpus allatum. Expression is also observed in dorsal somatic muscle and CNS.

Both svp transcripts are expressed in the same pattern during Malphighian tubule development. Expression is detected starting at embryonic stage 10 on one side of the outgrowing tubules, and during eversion, in a group of 6 to 8 cells in the tip region.

Using in situ hybridization, svp transcript is detected posterior to the morphogenetic furrow of the eye imaginal disc.

Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data

svp is expressed in two waves in the neuroblast NB5-6 of thorax during ventral nerve cord development.

svp is expressed in a subtype-specific fashion in the larval eye. In embryos, it is expressed in 8-10 immature photoreceptor cells. In the larva, it is expressed in the R6-specific photoreceptors of the Bolwig organ and is excluded from the R5 photoreceptors.

Expression of svp is observed in the two anterior-most pairs of cardioblasts in each abdominal hemisegment in the embryonic heart.

Marker for
Subcellular Localization
CV Term
Evidence
References
inferred from direct assay
Expression Deduced from Reporters
Reporter: P{A92}svpdon1
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{HZ}svp3
Stage
Tissue/Position (including subcellular localization)
Reference
neuroblast NB2-3

Comment: late stage 11

neuroblast NB3-3

Comment: late stage 11

neuroblast NB5-4

Comment: late stage 11

neuroblast NB4-4

Comment: late stage 11

neuroblast NB6-4

Comment: late stage 11

neuroblast NB4-2

Comment: late stage 11

neuroblast NB5-1

Comment: late stage 11

neuroblast NB2-4

Comment: late stage 11

neuroblast NB4-3

Comment: late stage 11

neuroblast NB3-4

Comment: late stage 11

neuroblast NB5-5

Comment: late stage 11

neuroblast NB3-1

Comment: late stage 11

neuroblast NB7-3

Comment: late stage 11

Reporter: P{lwB}svpAE127
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{PZ}svp07842
Stage
Tissue/Position (including subcellular localization)
Reference
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\svp in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, and Transgenic Constructs
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
photoreceptor cell & axon | somatic clone
photoreceptor cell R2 & axon
photoreceptor cell R5 & axon
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (7)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
10 of 15
Yes
Yes
 
10 of 15
Yes
Yes
6 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
 
1 of 15
No
No
1 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (6)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
11 of 15
Yes
Yes
10 of 15
No
Yes
5 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Rattus norvegicus (Norway rat) (6)
9 of 13
Yes
Yes
6 of 13
No
Yes
4 of 13
No
Yes
1 of 13
No
Yes
1 of 13
No
No
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (6)
8 of 12
Yes
Yes
8 of 12
Yes
Yes
5 of 12
No
Yes
4 of 12
No
Yes
1 of 12
No
No
1 of 12
No
No
Danio rerio (Zebrafish) (9)
10 of 15
Yes
Yes
9 of 15
No
Yes
8 of 15
No
Yes
6 of 15
No
Yes
6 of 15
No
Yes
5 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (7)
8 of 15
Yes
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091906OO )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Drosophila suzukii
Spotted wing Drosophila
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915071G )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0AUY )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0ARW )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0YX6 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (7)
3 of 10
2 of 10
2 of 10
2 of 10
2 of 10
1 of 10
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser

    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement

    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    External Data
    Linkouts
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3R
    Recombination map

    3-52

    Cytogenetic map
    Sequence location
    3R:12,258,737..12,302,785 [+]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    87B4-87B5
    Limits computationally determined from genome sequence between P{EP}Lk6EP886 and P{PZ}svp07842
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    87B3-87B5
    (determined by in situ hybridisation)
    87B4-87B6
    (determined by in situ hybridisation)
    87B-87B
    (determined by in situ hybridisation) 87B1--5 (determined by in situ hybridisation) 87B1--7 (determined by in situ hybridisation) 87B3--5 (determined by in situ hybridisation) 87B3--6 (determined by in situ hybridisation)
    87B3-87B5
    (determined by in situ hybridisation) 87B3--6 (determined by in situ hybridisation) 87B1--7 (determined by in situ hybridisation) 87B1--5 (determined by in situ hybridisation) 87B (determined by in situ hybridisation)
    Experimentally Determined Recombination Data
    Location
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (24)
    Genomic Clones (37)
    cDNA Clones (27)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequences
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    BDGP DGC clones
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Antibody Information
    Laboratory Generated Antibodies
     
    Commercially Available Antibodies
     
    Other Information
    Relationship to Other Genes
    Source for database identify of
    Source for database merge of

    Source for merge of: svp BcDNA:GH08189

    Source for merge of: svp CG18158

    Additional comments

    Annotations CG11502 and CG18158 merged as CG11502 in release 3 of the genome annotation.

    Source for merge of svp BcDNA:GH08189 was a shared cDNA ( date:030728 ).

    Of eight EMS-induced alleles listed by Gausz, Gyurkovics, Bencze, Awad, Holden and Ish-Horowicz, 1981 only two are now existent (svp1 and svp2).

    Other Comments

    RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.

    svp controls cell proliferation in the developing Malpighian tubules.

    lz controls svp and B expression in the developing eye disc, helping to define the fate of cells that arise from the second wave of mitotic division (R1/R6, R7 and cone cells).

    The expression pattern of proneural genes of the AS-C and neurogenic genes of the E(spl)-C are examined in the procephlon and a map of the cells is constructed.

    All components of the Ras85D signal transduction cascade are required for svp function acting as suppressors of the cone cell transformation.

    svp embryos show no defects in the neuroblast pattern, developmental errors start when svp expression is extinguished from the neuroblasts. Fewer than normal eve positive cells join the growing EL neuronal cluster, late embryonic CNS shows widespread anatomical disorganisation of neuronal cell bodies, axon tracts and glia.

    Four neuroblast molecular markers (svp, pros, en and ftz) have been used to demonstrate that some neuroblasts are homologous between insects (Drosophila and Schistocerca). They have similar position, time of formation and time of gene expression. Results suggest that evolution of the insect CNS has occurred in part through altering the neuroblast pattern and fate.

    Different cell types within an ommatidium respond differently to misexpression of svp and the effect of misexpression can be modified by decreasing the ras signalling activity. This suggests an interaction between ras and svp in mediating cell fate decisions in the compound eye.

    The svp product can bind to a variety of hormone response elements containing the repeat AGGTCA and modulates usp product-based signalling both in vitro and in vivo. Ectopic expression of svp in vivo leads to lethality at times corresponding to peaks of ecdysone expression. Concomitant overexpression of usp rescues the larva from the lethal effects of svp.

    svp-mediated repression of ecdysone signalling can occur by both DNA binding competition and protein-protein interactions.

    svp plays a role in fat-body-specific expression of two terminal fat cell differentiation markers, Adh and Cg25C.

    Ectopic expression of svp causes cell fate changes during ommatidial assembly, with R7 being transformed to R1-R6.

    Expression analysed in CNS study of neuroblasts and ganglion mother cells, using an enhancer trap to reveal the expression pattern.

    Evolutionary history for nuclear receptor genes, in which gene duplication events and swapping between domains of different origins took place, is studied.

    svp is required for eye development in photoreceptors R1, R3, R4 and R6.

    Mutant clonal analysis reveals that svp is required for normal receptor cell development in photoreceptors 1, 3, 4 and 6.

    Originally identified as recessive lethal mutations; independently identified by an enhancer-trap screen to be a gene expressed in a subset of neuroblasts in the embryonic CNS and also in a subset of photoreceptor-cell precursors in the developing compound eye. Mutant alleles die as embryos with normal cuticular morphology, but have alterations in numbers of eve-positive neurons in some neuroblast lineages. svp- clones in the eye produce abnormal ommatidia where photoreceptors R1, R3, R4 and R6 are transformed toward another photoreceptor R7. In addition, svp- ommatidia usually contain one to two extra photoreceptor cells. Mosaic studies show that transformation towards R7 is due to cell autonomous requirement in R1, R3, R4 and R6, whereas production of extra cell(s) is a secondary phenotype caused by lack of svp+ function in other cells, most likely in R3 and R4. Formation of some, but not all, R7-like cells in svp- ommatidia is dependent on sev+ function.

    Origin and Etymology
    Discoverer
    Etymology
    Identification
    External Crossreferences and Linkouts ( 72 )
    Sequence Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
    Other crossreferences
    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    Flygut - An atlas of the Drosophila adult midgut
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
    KEGG Genes - Molecular building blocks of life in the genomic space.
    modMine - A data warehouse for the modENCODE project
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DPiM - Drosophila Protein interaction map
    DroID - A comprehensive database of gene and protein interactions.
    DRSC - Results frm RNAi screens
    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
    FlyMine - An integrated database for Drosophila genomics
    Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    Synonyms and Secondary IDs (35)
    Reported As
    Symbol Synonym
    BcDNA:GH08189
    l(3)07842
    l(3)87Bd
    l(3)j2E2
    l(3)rA028
    l(3)rL069
    svp
    (Chai et al., 2019, FlyBase Genome Annotators, 2019-, Lehmann et al., 2019, Oberst et al., 2019, Sapar and Han, 2019, Shokri et al., 2019, Thuveson et al., 2019, Landskron et al., 2018, Schwarz et al., 2018, Ugrankar et al., 2018, Hu et al., 2017.6.13, Mishra et al., 2016, Narbonne-Reveau et al., 2016, Stratmann et al., 2016, Trujillo et al., 2016, Urbach et al., 2016, Zacharioudaki et al., 2016, Zheng et al., 2016, Bivik et al., 2015, Gene Disruption Project members, 2015-, Jaumouillé et al., 2015, Kern et al., 2015, Schertel et al., 2015, Ugrankar et al., 2015, DeSalvo et al., 2014, Dong et al., 2014, Jussen and Urbach, 2014, Makki et al., 2014, Rogers et al., 2014, Sánchez-Higueras et al., 2014, Aleksic et al., 2013, Brown et al., 2013, Chai et al., 2013, Eguchi et al., 2013, Mishra et al., 2013, Sen et al., 2013, Ahmad et al., 2012, Cheutin and Cavalli, 2012, Kunz et al., 2012, Spokony and White, 2012.5.22, Yoshioka et al., 2012, Albrecht et al., 2011, Benchabane et al., 2011, Benito-Sipos et al., 2011, Dubrovsky et al., 2011, Endo et al., 2011, Gambis et al., 2011, Grigorian et al., 2011, Jungreis et al., 2011, Kohwi et al., 2011, Kuzin et al., 2011, Seong et al., 2011, Buffin and Gho, 2010, Nakajima et al., 2010, Babaoglan et al., 2009, Dworkin et al., 2009, Ho et al., 2009, LaBeau et al., 2009, Liu et al., 2009, Beckervordersandforth et al., 2008, Benchabane et al., 2008, Das et al., 2008, DeFalco et al., 2008, Iklé et al., 2008, Maurange et al., 2008, Miller et al., 2008, Ryan and Cripps, 2008, Sprecher and Desplan, 2008, Takacs et al., 2008, Tran and Doe, 2008, Eder and Urban, 2007, Firth and Baker, 2007, Gebelein and Mann, 2007, Grieder et al., 2007, Ryan et al., 2007, Sprecher et al., 2007, Zeitlinger et al., 2007, Albrecht et al., 2006, Urbach et al., 2006, Zaffran et al., 2006, Glazov et al., 2005, Iwanami et al., 2005, Kanai et al., 2005, Odenwald, 2005, Brodu et al., 2004, Chang et al., 2003, Enright et al., 2003)
    Secondary FlyBase IDs
    • FBgn0011337
    • FBgn0011492
    • FBgn0011510
    • FBgn0038010
    • FBgn0063263
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    References (399)