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Gene Dmel\sw

General Information
Symbol	Dmel\sw	Species	D. melanogaster
Name	short wing	Annotation symbol	CG18000
Feature type	protein_coding_gene	FlyBase ID	FBgn0003654
Gene Model Status	Current	Stock availability	10 publicly available
Also Known As	Cdic, DIC, IC, 17-234, Dic19C, IC74, Cdic2b
Genomic Location
Chromosome (arm)	X	Recombination map	1-64.0
Cytogenetic map	19C1-19C1	Sequence location	X:20,099,035..20,107,456 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene short wing is referred to in FlyBase by the symbol Dmel\sw (CG18000, FBgn0003654). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: dynein light chain binding. There is experimental evidence that it is involved in the biological process: centrosome localization; cytoplasmic transport; protein localization to kinetochore; sperm individualization; microtubule cytoskeleton organization; eye photoreceptor cell differentiation; spindle organization; axon cargo transport. 45 alleles are reported. The phenotypes of these alleles are annotated with: wing margin; eye; mesothoracic tergum; cystic bulge; wing; dendritic arborizing neuron; ommatidium; wing vein. It has 15 annotated transcripts and 15 annotated polypeptides. Protein features are: Cytoplasmic dynein 1 intermediate chain 1/2; WD40 repeat; WD40-repeat-containing domain; WD40/YVTN repeat-like-containing domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed in adult male stages. Summary of FlyAtlas Anatomical Expression Data: No FlyAtlas data available because no Affy2 ProbeSet aligns to an exon of sw. Comments on Affy2 ProbeSet: No relevant information because no Affy2 ProbeSet aligns to an exon of sw. Gene sequence location is X:20099035..20107456.
User Contributed Data
	Beta version, feedback welcome
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	sw: short wing sw: short wing From Eker, 1935, J. Genet. 30: 357-68. Above 23, most sw1 flies have spread and incised wings with irregular veins; eyes reduced and roughened. Male expression more extreme than female. 15% of males eclose at 25; show wing and eye abnormalities (Schalet, 1969, DIS 43: 128); above 31, sw is lethal. At 17, most flies are wild type; at 14, all are wild type. +/Df(1)mal10 and +/sw exhibit short-wing phenotype in presence of RpII215Ubl (Mortin and Lefevre, 1981, Chromosoma 82: 237-47). RK2 at 28.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 19C1-19C1   Limits computationally determined from genome sequence between P{EP}amnEP1639&P{EP}amnEP367 and P{EP}CG1702EP1525
Experimentally Determined Cytological Location
Cytogenetic map Notes References 19C-19C   (determined by in situ hybridisation)   (Boylan et al., 2000) 19B-19B     (Boylan, 2000.5.3) 19D-19E     (Nurminsky, 1998.6.3) 19A4-19A7     (Benevolenskaya, 1995) 19E-19E   (determined by in situ hybridisation)   (Nurminsky et al., 1998) 19B-19B   (determined by in situ hybridisation)   (Benevolenskaya et al., 1995)
Experimentally Determined Recombination Data
Location	1-64.0   1- (Benevolenskaya, 1995)
Left of (cM)	mel
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\sw for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.50 Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters. Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) sw-RA FBtr0089397  NM_057726   2699   634 sw-RB FBtr0089398  NM_057729   2841   627 sw-RC FBtr0089399  NM_057728   2838   626 sw-RD FBtr0089400  NM_057721   2889   643 sw-RE FBtr0089401  NM_057730   3070   642 sw-RF FBtr0089402  NM_057731   2910   650 sw-RG FBtr0089403  NM_057722   2868   636 sw-RH FBtr0089404  NM_057723   2702   635 sw-RI FBtr0089405  NM_057724   2678   627 sw-RJ FBtr0089406  NM_057727   2786   663 sw-RK FBtr0089407  NM_057725   2756   653 sw-RL FBtr0089408  NM_206799   3032   643 sw-RM FBtr0089409  NM_206798   2873   643 sw-RN FBtr0340360     2862   634 sw-RO FBtr0340361     2889   643
Additional Transcript Data & Comments
Reported size (kB)	2.8 (northern blot) (Nurminsky et al., 1998)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein sw-PA   FBpp0088419   70.2   634   5.03     NP_477074   AAN09558 sw-PB   FBpp0088420   69.5   627   5.09     NP_477077   AAN09557 sw-PC   FBpp0088421   69.4   626   5.09     NP_477076   AAN09556 sw-PD   FBpp0088422   71.5   643   4.82     NP_477069   AAN09560 sw-PE   FBpp0088423   71.4   642   4.82     NP_477078   AAN09559 sw-PF   FBpp0088424   72.2   650   4.78     NP_477079   AAN09561 sw-PG   FBpp0088425   70.6   636   4.81     NP_477070   AAN09555 sw-PH   FBpp0088426   70.6   635   4.81     NP_477071   AAN09554 sw-PI   FBpp0088427   69.4   627   5.03     NP_477072   AAN09553 sw-PJ   FBpp0088428   73.9   663   4.91     NP_477075   AAF50928 sw-PK   FBpp0088429   72.9   653   4.87     NP_477073   AAN09562 sw-PL   FBpp0089020   71.5   643   4.82     NP_996522   AAS65417 sw-PM   FBpp0089021   71.5   643   4.82     NP_996521   AAS65418 sw-PN   FBpp0309318   70.2   634   5.03       sw-PO   FBpp0309319   71.4   643   4.78
Additional Polypeptide Data & Comments
Reported size (kDa)	653, 650, 643, 642, 636, 635, 634, 627, 626, 163 (aa) (Nurminsky et al., 1998)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • WD40/YVTN repeat-like-containing domain (IPR015943) WD40-repeat-containing domain (IPR017986) WD40 repeat (IPR001680) Cytoplasmic dynein 1 intermediate chain 1/2 (IPR025956)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA440474   AA695746   AA699119   AA735792   AA803509   AA941650   AA950206   AA951344   AA951346   AE014298 AAF50928   AE014298 AAN09553   AE014298 AAN09554   AE014298 AAN09555   AE014298 AAN09556   AE014298 AAN09557   AE014298 AAN09558   AE014298 AAN09559   AE014298 AAN09560   AE014298 AAN09561   AE014298 AAN09562   AE014298 AAS65417   AE014298 AAS65418   AF070687 AAC78306   AF070689 AAC70933   AF070690 AAC70934   AF070691 AAC70935   AF070692 AAC70936   AF070693 AAC70937   AF070694 AAC70938   AF070695 AAC70939   AF070696 AAC70940   AF070697 AAC70941   AF070698 AAC70942   AF070699 AAC70943   AF263371 AAF73046   AI063213   AI064554   AI134009   AI402440   AI456082   AI512155   AI512194   AI512495   AI517033   AI517853   AI519120   AI532310   AI533661   AI534345   AI541888   AI543070   AI543842   AY118956 AAM50816   BF490851   BF493614   BF494876   BF498887   BF502385   BF504895   BG632943   BG639065   BI164999   BI171171   BI212722   BI215488   BI216801   BI216815   BI227819   BI230935   BI234932   BI356891   BI366759   BI371640   BI482517   BI482529   BI484361   BI572289   BI572453   BI574378   BI578949   BI590177   BI607914   BI612470   BI620455   BI626779   BI635416   BI636153   BI636236   BI637026   BI639998   BT016101 AAV36986   BT021459   BT044472   BT124855   BT125890   BT125898   BT125953   BT125962   BT126009   BT126135   BT126328   CK604268   CK604269   CK658088   CO177052   CO187263   CO189496   CO262750   CO265111   CO265410   CO271513   CO272356   CO280304   CO284819   CO287162   CO292366   CO295986   CO297344   CO299022   CO304848   CO307709   CO311558   CO314653   CO315445   CO316875   CO317296   CO317426   CO319693   CO326075   CO331020   CO340350   CO341490   CO341624   CX309435   CZ482278   EC051823   EC056993   EC082992   EC086506   EC086924   EC090435   EC197885   EC203236   EC204563   EC206786   EC208060   EC208061   EC210168   EC210716   EC212513   EC213242   EC214257   EC215356   EC215451   EC215892   EC217708   EC226486   EC229462   EC230147   EC236185   EC238353   EC241577   EC247363   EC249940   EC250946   EC253475   EC255832   EL874349   EL874350   EV580947   EV581186   GH941775   GH941956   GH944009   GH944255   GH945928   GH945967   GH946028   GH946248   GH947002   GH947111   GH947539   GH948505   GH948996   GH949199   GH949450   GH949753   GH950084   GH950868   GH950898   GH952568   GH953268   GH953304   GH953665   GH953795   GH954332   GH954608   GH956154   GH956421   GH956573   GH956649   GH957445   GH957734   GH957891   GH958523   GH958904   GH960004   GH960061   GH960365   GH964113   GH964433   GH966151   GH966617   GH966636   GH966669   GH966845   GH967398   GH967636   GH967653   GH968410   GH969403   GH969570   GH969883   GH970411   GH971081   GH971696   GH971928   GH971998   GH972000   GH972042   GH972549   GH973771   GH974258   GH975220   GH976183   GH976465   GH976652   GH976706   GH976712   GH977225   GH977606   GH977698   GH977928   GH978281   GH980062   GH980140   GH981373   GH981588   GH982138   GH982554   GH982621   GH982859   GH983271   GH983846   GH984213   GH984535   GH984595   GH984999   L41945 AAB51185   Z32429   Z32430
UniProtKB/Swiss-Prot	Q24246
UniProtKB/TrEMBL	A4V4T4 Q8MSA9
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic brain   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage & adult stage     (Nurminsky et al., 1998)
Additional Descriptive Data
	"Cdic2c" is a minor form of sw mRNA which is constitutively expressed at a low level. (Nurminsky et al., 1998) "Cdic5a" is a minor form of sw mRNA which is up-regulated in the head and to a lesser extent in the torso. (Nurminsky et al., 1998) "Cdic1a" is one of the major forms of sw mRNA expressed in the fly. It is constitutively expressed and together with "Cdic2a" and "Cdic2b" makes up over 70% if the sw mRNA in adults, embryos and all tested body parts. (Nurminsky et al., 1998) "Cdic2a" is one of the major forms of sw mRNA expressed in the fly. It is constitutively expressed and together with "Cdic1a" and "Cdic2b" makes up over 70% if the sw mRNA in adults, embryos and all tested body parts. (Nurminsky et al., 1998) "Cdic5b" is a minor form of sw mRNA which is up-regulated in the head and to a lesser extent in the torso. (Nurminsky et al., 1998) "Cdic2b" is one of the major forms of sw mRNA expressed in the fly. It is constitutively expressed and together with "Cdic1a" and "Cdic2a" makes up over 70% if the sw mRNA in adults, embryos and all tested body parts. (Nurminsky et al., 1998) "Cdic1c" is a minor form of sw mRNA which is up-regulated in the ovary. (Nurminsky et al., 1998) "Cdic3b" is a minor form of sw mRNA which is up-regulated in the ovary. (Nurminsky et al., 1998) "Cdic4" is a minor form of sw mRNA which is up-regulated in the ovary. (Nurminsky et al., 1998) "Cdic1b" is a minor form of sw mRNA which is up-regulated in the ovary. (Nurminsky et al., 1998) "Cdic3a" is a minor form of sw mRNA which is up-regulated in the ovary. (Nurminsky et al., 1998)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
microtubule associated complex inferred from direct assay (Hughes et al., 2008)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    73 central nervous system, larvae L3    63 central nervous system, pupae P8    37 head, virgin 1-day female    30 head, virgin 4-day female    32 head, virgin 20-day female    28 head, mated 1-day female    29 head, mated 4-day female    28 head, mated 20-day female    28 head, mated 1-day male    47 head, mated 4-day male    45 head, mated 20-day male    43 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    25 digestive system, larvae L3 wandering    46 digestive system, 1-day adult    34 digestive system, 4-day adult    27 digestive system, 20-day adult    37 fat body, larvae L3 wandering    19 fat body, white prepupae    32 fat body, pupae P8    35 carcass, larvae L3 wandering    50 carcass, 1-day adult    26 carcass, 4-day adult    26 carcass, 20-day adult    28 ovary, virgin 4-day female    45 ovary, mated 4-day female    47 testis, mated 4-day male    83 accessory gland, mated 4-day male    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (73) central nervous system, larvae L3  (63) central nervous system, pupae P8  (37) head, virgin 1-day female  (30) head, virgin 4-day female  (32) head, virgin 20-day female  (28) head, mated 1-day female  (29) head, mated 4-day female  (28) head, mated 20-day female  (28) head, mated 1-day male  (47) head, mated 4-day male  (45) head, mated 20-day male  (43) salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    25 digestive system, larvae L3 wandering  (46) digestive system, 1-day adult  (34) digestive system, 4-day adult  (27) digestive system, 20-day adult  (37) fat body, larvae L3 wandering    19 fat body, white prepupae  (32) fat body, pupae P8  (35) carcass, larvae L3 wandering  (50) carcass, 1-day adult  26 carcass, 4-day adult  26 carcass, 20-day adult  (28) ovary, virgin 4-day female  (45) ovary, mated 4-day female  (47) testis, mated 4-day male  (83) accessory gland, mated 4-day male    25 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    73 central nervous system, larvae L3    63 central nervous system, pupae P8    37 head, virgin 1-day female    30 head, virgin 4-day female    32 head, virgin 20-day female    28 head, mated 1-day female    29 head, mated 4-day female    28 head, mated 20-day female    28 head, mated 1-day male    47 head, mated 4-day male    45 head, mated 20-day male    43 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    25 digestive system, larvae L3 wandering    46 digestive system, 1-day adult    34 digestive system, 4-day adult    27 digestive system, 20-day adult    37 fat body, larvae L3 wandering    19 fat body, white prepupae    32 fat body, pupae P8    35 carcass, larvae L3 wandering    50 carcass, 1-day adult    26 carcass, 4-day adult    26 carcass, 20-day adult    28 ovary, virgin 4-day female    45 ovary, mated 4-day female    47 testis, mated 4-day male    83 accessory gland, mated 4-day male    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    73 central nervous system, larvae L3    63 central nervous system, pupae P8    37 head, virgin 1-day female    30 head, virgin 4-day female    32 head, virgin 20-day female    28 head, mated 1-day female    29 head, mated 4-day female    28 head, mated 20-day female    28 head, mated 1-day male    47 head, mated 4-day male    45 head, mated 20-day male    43 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    25 digestive system, larvae L3 wandering    46 digestive system, 1-day adult    34 digestive system, 4-day adult    27 digestive system, 20-day adult    37 fat body, larvae L3 wandering    19 fat body, white prepupae    32 fat body, pupae P8    35 carcass, larvae L3 wandering    50 carcass, 1-day adult    26 carcass, 4-day adult    26 carcass, 20-day adult    28 ovary, virgin 4-day female    45 ovary, mated 4-day female    47 testis, mated 4-day male    83 accessory gland, mated 4-day male    25 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    73 central nervous system, larvae L3    63 central nervous system, pupae P8    37 head, virgin 1-day female    30 head, virgin 4-day female    32 head, virgin 20-day female    28 head, mated 1-day female    29 head, mated 4-day female    28 head, mated 20-day female    28 head, mated 1-day male    47 head, mated 4-day male    45 head, mated 20-day male    43 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    25 digestive system, larvae L3 wandering    46 digestive system, 1-day adult    34 digestive system, 4-day adult    27 digestive system, 20-day adult    37 fat body, larvae L3 wandering    19 fat body, white prepupae    32 fat body, pupae P8    35 carcass, larvae L3 wandering    50 carcass, 1-day adult    26 carcass, 4-day adult    26 carcass, 20-day adult    28 ovary, virgin 4-day female    45 ovary, mated 4-day female    47 testis, mated 4-day male    83 accessory gland, mated 4-day male    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (73) central nervous system, larvae L3  (63) central nervous system, pupae P8  (37) head, virgin 1-day female  30 head, virgin 4-day female  32 head, virgin 20-day female  28 head, mated 1-day female  29 head, mated 4-day female  28 head, mated 20-day female  28 head, mated 1-day male  (47) head, mated 4-day male  (45) head, mated 20-day male  (43) salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    25 digestive system, larvae L3 wandering  (46) digestive system, 1-day adult  (34) digestive system, 4-day adult  27 digestive system, 20-day adult  (37) fat body, larvae L3 wandering    19 fat body, white prepupae  32 fat body, pupae P8  (35) carcass, larvae L3 wandering  (50) carcass, 1-day adult  26 carcass, 4-day adult  26 carcass, 20-day adult  28 ovary, virgin 4-day female  (45) ovary, mated 4-day female  (47) testis, mated 4-day male  (83) accessory gland, mated 4-day male    25 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    73 central nervous system, larvae L3    63 central nervous system, pupae P8    37 head, virgin 1-day female    30 head, virgin 4-day female    32 head, virgin 20-day female    28 head, mated 1-day female    29 head, mated 4-day female    28 head, mated 20-day female    28 head, mated 1-day male    47 head, mated 4-day male    45 head, mated 20-day male    43 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    25 digestive system, larvae L3 wandering    46 digestive system, 1-day adult    34 digestive system, 4-day adult    27 digestive system, 20-day adult    37 fat body, larvae L3 wandering    19 fat body, white prepupae    32 fat body, pupae P8    35 carcass, larvae L3 wandering    50 carcass, 1-day adult    26 carcass, 4-day adult    26 carcass, 20-day adult    28 ovary, virgin 4-day female    45 ovary, mated 4-day female    47 testis, mated 4-day male    83 accessory gland, mated 4-day male    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    73 central nervous system, larvae L3    63 central nervous system, pupae P8    37 head, virgin 1-day female    30 head, virgin 4-day female    32 head, virgin 20-day female    28 head, mated 1-day female    29 head, mated 4-day female    28 head, mated 20-day female    28 head, mated 1-day male    47 head, mated 4-day male    45 head, mated 20-day male    43 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    25 digestive system, larvae L3 wandering    46 digestive system, 1-day adult    34 digestive system, 4-day adult    27 digestive system, 20-day adult    37 fat body, larvae L3 wandering    19 fat body, white prepupae    32 fat body, pupae P8    35 carcass, larvae L3 wandering    50 carcass, 1-day adult    26 carcass, 4-day adult    26 carcass, 20-day adult    28 ovary, virgin 4-day female    45 ovary, mated 4-day female    47 testis, mated 4-day male    83 accessory gland, mated 4-day male    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    15 embryo 02-04hr    14 embryo 04-06hr    6 embryo 06-08hr    7 embryo 08-10hr    8 embryo 10-12hr    8 embryo 12-14hr    8 embryo 14-16hr    8 embryo 16-18hr    8 embryo 18-20hr    8 embryo 20-22hr    10 embryo 22-24hr    8 larva L1    7 larva L2    8 larva L3 12hr old    8 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    9 white prepupae new    10 white prepupae 12hr    11 white prepupae 24hr    13 pupae 2d postWPP    9 pupae 3d postWPP    6 pupae 4d postWPP    9 adult male 01day    11 adult male 05day    26 adult male 30day    8 adult female 01day    9 adult female 05day    15 adult female 30day    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    15 embryo 02-04hr    14 embryo 04-06hr    6 embryo 06-08hr    7 embryo 08-10hr    8 embryo 10-12hr    8 embryo 12-14hr    8 embryo 14-16hr    8 embryo 16-18hr    8 embryo 18-20hr    8 embryo 20-22hr    10 embryo 22-24hr    8 larva L1    7 larva L2    8 larva L3 12hr old    8 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    9 white prepupae new    10 white prepupae 12hr    11 white prepupae 24hr    13 pupae 2d postWPP    9 pupae 3d postWPP    6 pupae 4d postWPP    9 adult male 01day    11 adult male 05day  26 adult male 30day    8 adult female 01day    9 adult female 05day    15 adult female 30day    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    15 embryo 02-04hr    14 embryo 04-06hr    6 embryo 06-08hr    7 embryo 08-10hr    8 embryo 10-12hr    8 embryo 12-14hr    8 embryo 14-16hr    8 embryo 16-18hr    8 embryo 18-20hr    8 embryo 20-22hr    10 embryo 22-24hr    8 larva L1    7 larva L2    8 larva L3 12hr old    8 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    9 white prepupae new    10 white prepupae 12hr    11 white prepupae 24hr    13 pupae 2d postWPP    9 pupae 3d postWPP    6 pupae 4d postWPP    9 adult male 01day    11 adult male 05day    26 adult male 30day    8 adult female 01day    9 adult female 05day    15 adult female 30day    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    15 embryo 02-04hr    14 embryo 04-06hr    6 embryo 06-08hr    7 embryo 08-10hr    8 embryo 10-12hr    8 embryo 12-14hr    8 embryo 14-16hr    8 embryo 16-18hr    8 embryo 18-20hr    8 embryo 20-22hr    10 embryo 22-24hr    8 larva L1    7 larva L2    8 larva L3 12hr old    8 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    9 white prepupae new    10 white prepupae 12hr    11 white prepupae 24hr    13 pupae 2d postWPP    9 pupae 3d postWPP    6 pupae 4d postWPP    9 adult male 01day    11 adult male 05day    26 adult male 30day    8 adult female 01day    9 adult female 05day    15 adult female 30day    14 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    15 embryo 02-04hr    14 embryo 04-06hr    6 embryo 06-08hr    7 embryo 08-10hr    8 embryo 10-12hr    8 embryo 12-14hr    8 embryo 14-16hr    8 embryo 16-18hr    8 embryo 18-20hr    8 embryo 20-22hr    10 embryo 22-24hr    8 larva L1    7 larva L2    8 larva L3 12hr old    8 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    9 white prepupae new    10 white prepupae 12hr    11 white prepupae 24hr    13 pupae 2d postWPP    9 pupae 3d postWPP    6 pupae 4d postWPP    9 adult male 01day    11 adult male 05day    26 adult male 30day    8 adult female 01day    9 adult female 05day    15 adult female 30day    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    15 embryo 02-04hr    14 embryo 04-06hr    6 embryo 06-08hr    7 embryo 08-10hr    8 embryo 10-12hr    8 embryo 12-14hr    8 embryo 14-16hr    8 embryo 16-18hr    8 embryo 18-20hr    8 embryo 20-22hr    10 embryo 22-24hr    8 larva L1    7 larva L2    8 larva L3 12hr old    8 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    9 white prepupae new    10 white prepupae 12hr    11 white prepupae 24hr    13 pupae 2d postWPP    9 pupae 3d postWPP    6 pupae 4d postWPP    9 adult male 01day    11 adult male 05day  26 adult male 30day    8 adult female 01day    9 adult female 05day    15 adult female 30day    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    15 embryo 02-04hr    14 embryo 04-06hr    6 embryo 06-08hr    7 embryo 08-10hr    8 embryo 10-12hr    8 embryo 12-14hr    8 embryo 14-16hr    8 embryo 16-18hr    8 embryo 18-20hr    8 embryo 20-22hr    10 embryo 22-24hr    8 larva L1    7 larva L2    8 larva L3 12hr old    8 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    9 white prepupae new    10 white prepupae 12hr    11 white prepupae 24hr    13 pupae 2d postWPP    9 pupae 3d postWPP    6 pupae 4d postWPP    9 adult male 01day    11 adult male 05day    26 adult male 30day    8 adult female 01day    9 adult female 05day    15 adult female 30day    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    15 embryo 02-04hr    14 embryo 04-06hr    6 embryo 06-08hr    7 embryo 08-10hr    8 embryo 10-12hr    8 embryo 12-14hr    8 embryo 14-16hr    8 embryo 16-18hr    8 embryo 18-20hr    8 embryo 20-22hr    10 embryo 22-24hr    8 larva L1    7 larva L2    8 larva L3 12hr old    8 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    9 white prepupae new    10 white prepupae 12hr    11 white prepupae 24hr    13 pupae 2d postWPP    9 pupae 3d postWPP    6 pupae 4d postWPP    9 adult male 01day    11 adult male 05day    26 adult male 30day    8 adult female 01day    9 adult female 05day    15 adult female 30day    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    89 Schneider line 2 Sg4    34 embryonic 1182-4H    76 embryonic GM2    31 embryonic Kc167    26 embryonic S1    82 embryonic S3    29 leg disc CME L1    52 wing disc CME-W2    24 wing disc ML-DmD8    26 wing disc ML-DmD9    64 wing disc ML-DmD16-c3    73 wing disc ML-DmD21    46 wing disc ML-DmD32    56 haltere disc ML-DmD17-c3    39 eye-antennal disc ML-DmD11    58 antennal disc ML-DmD20-c5    33 mixed discs ML-DmD4-c1    43 CNS ML-DmBG1-c1    55 CNS ML-DmBG2-c2    28 tumorous blood cells mbn2    29 ovary fGS/OSS    58 ovary OSC    44 ovary OSS    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (89) Schneider line 2 Sg4  (34) embryonic 1182-4H  (76) embryonic GM2  (31) embryonic Kc167  26 embryonic S1  (82) embryonic S3  (29) leg disc CME L1  (52) wing disc CME-W2    24 wing disc ML-DmD8  26 wing disc ML-DmD9  (64) wing disc ML-DmD16-c3  (73) wing disc ML-DmD21  (46) wing disc ML-DmD32  (56) haltere disc ML-DmD17-c3  (39) eye-antennal disc ML-DmD11  (58) antennal disc ML-DmD20-c5  (33) mixed discs ML-DmD4-c1  (43) CNS ML-DmBG1-c1  (55) CNS ML-DmBG2-c2  (28) tumorous blood cells mbn2  (29) ovary fGS/OSS  (58) ovary OSC  (44) ovary OSS  (27) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    89 Schneider line 2 Sg4    34 embryonic 1182-4H    76 embryonic GM2    31 embryonic Kc167    26 embryonic S1    82 embryonic S3    29 leg disc CME L1    52 wing disc CME-W2    24 wing disc ML-DmD8    26 wing disc ML-DmD9    64 wing disc ML-DmD16-c3    73 wing disc ML-DmD21    46 wing disc ML-DmD32    56 haltere disc ML-DmD17-c3    39 eye-antennal disc ML-DmD11    58 antennal disc ML-DmD20-c5    33 mixed discs ML-DmD4-c1    43 CNS ML-DmBG1-c1    55 CNS ML-DmBG2-c2    28 tumorous blood cells mbn2    29 ovary fGS/OSS    58 ovary OSC    44 ovary OSS    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    89 Schneider line 2 Sg4    34 embryonic 1182-4H    76 embryonic GM2    31 embryonic Kc167    26 embryonic S1    82 embryonic S3    29 leg disc CME L1    52 wing disc CME-W2    24 wing disc ML-DmD8    26 wing disc ML-DmD9    64 wing disc ML-DmD16-c3    73 wing disc ML-DmD21    46 wing disc ML-DmD32    56 haltere disc ML-DmD17-c3    39 eye-antennal disc ML-DmD11    58 antennal disc ML-DmD20-c5    33 mixed discs ML-DmD4-c1    43 CNS ML-DmBG1-c1    55 CNS ML-DmBG2-c2    28 tumorous blood cells mbn2    29 ovary fGS/OSS    58 ovary OSC    44 ovary OSS    27 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    89 Schneider line 2 Sg4    34 embryonic 1182-4H    76 embryonic GM2    31 embryonic Kc167    26 embryonic S1    82 embryonic S3    29 leg disc CME L1    52 wing disc CME-W2    24 wing disc ML-DmD8    26 wing disc ML-DmD9    64 wing disc ML-DmD16-c3    73 wing disc ML-DmD21    46 wing disc ML-DmD32    56 haltere disc ML-DmD17-c3    39 eye-antennal disc ML-DmD11    58 antennal disc ML-DmD20-c5    33 mixed discs ML-DmD4-c1    43 CNS ML-DmBG1-c1    55 CNS ML-DmBG2-c2    28 tumorous blood cells mbn2    29 ovary fGS/OSS    58 ovary OSC    44 ovary OSS    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (89) Schneider line 2 Sg4  (34) embryonic 1182-4H  (76) embryonic GM2  31 embryonic Kc167  26 embryonic S1  (82) embryonic S3  29 leg disc CME L1  (52) wing disc CME-W2    24 wing disc ML-DmD8  26 wing disc ML-DmD9  (64) wing disc ML-DmD16-c3  (73) wing disc ML-DmD21  (46) wing disc ML-DmD32  (56) haltere disc ML-DmD17-c3  (39) eye-antennal disc ML-DmD11  (58) antennal disc ML-DmD20-c5  (33) mixed discs ML-DmD4-c1  (43) CNS ML-DmBG1-c1  (55) CNS ML-DmBG2-c2  28 tumorous blood cells mbn2  29 ovary fGS/OSS  (58) ovary OSC  (44) ovary OSS  27 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    89 Schneider line 2 Sg4    34 embryonic 1182-4H    76 embryonic GM2    31 embryonic Kc167    26 embryonic S1    82 embryonic S3    29 leg disc CME L1    52 wing disc CME-W2    24 wing disc ML-DmD8    26 wing disc ML-DmD9    64 wing disc ML-DmD16-c3    73 wing disc ML-DmD21    46 wing disc ML-DmD32    56 haltere disc ML-DmD17-c3    39 eye-antennal disc ML-DmD11    58 antennal disc ML-DmD20-c5    33 mixed discs ML-DmD4-c1    43 CNS ML-DmBG1-c1    55 CNS ML-DmBG2-c2    28 tumorous blood cells mbn2    29 ovary fGS/OSS    58 ovary OSC    44 ovary OSS    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    89 Schneider line 2 Sg4    34 embryonic 1182-4H    76 embryonic GM2    31 embryonic Kc167    26 embryonic S1    82 embryonic S3    29 leg disc CME L1    52 wing disc CME-W2    24 wing disc ML-DmD8    26 wing disc ML-DmD9    64 wing disc ML-DmD16-c3    73 wing disc ML-DmD21    46 wing disc ML-DmD32    56 haltere disc ML-DmD17-c3    39 eye-antennal disc ML-DmD11    58 antennal disc ML-DmD20-c5    33 mixed discs ML-DmD4-c1    43 CNS ML-DmBG1-c1    55 CNS ML-DmBG2-c2    28 tumorous blood cells mbn2    29 ovary fGS/OSS    58 ovary OSC    44 ovary OSS    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    33 cold shock, 4-day adult    25 heat shock, 4-day adult    30 Cadmium 50 mM 6 hrs, larvae L3    24 Cadmium 50 mM 12 hrs, larvae L3    16 Cadmium 50 mM 48 hrs, 4-day adult    27 Cadmium 100 mM 48 hrs, 4-day adult    39 Copper 0.5 mM 12 hrs, larvae L3    30 Copper 15 mM 48 hrs, 4-day adult    15 Zinc 5 mM 12 hrs, larvae L3    21 Zinc 4.5 mM 48 hrs, 4-day adult    25 Ethanol 2.5% 3 hrs, larvae L3    41 Ethanol 5% 3 hrs, larvae L3    23 Ethanol 10% 3 hrs, larvae L3    24 Caffeine 1.5 mg/ml 4 hrs, larvae L3    20 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    38 Caffeine 25 mg/ml 48 hrs, 4-day adult    26 Paraquat 5 mM 48 hrs, 4-day adult    37 Paraquat 10 mM 48 hrs, 4-day adult    47 Rotenone 2 μg 12 hrs, larvae L3    21 Rotenone 8 μg 12 hrs, larvae L3    26 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (33) cold shock, 4-day adult    25 heat shock, 4-day adult  (30) Cadmium 50 mM 6 hrs, larvae L3    24 Cadmium 50 mM 12 hrs, larvae L3    16 Cadmium 50 mM 48 hrs, 4-day adult  (27) Cadmium 100 mM 48 hrs, 4-day adult  (39) Copper 0.5 mM 12 hrs, larvae L3  (30) Copper 15 mM 48 hrs, 4-day adult    15 Zinc 5 mM 12 hrs, larvae L3    21 Zinc 4.5 mM 48 hrs, 4-day adult    25 Ethanol 2.5% 3 hrs, larvae L3  (41) Ethanol 5% 3 hrs, larvae L3    23 Ethanol 10% 3 hrs, larvae L3    24 Caffeine 1.5 mg/ml 4 hrs, larvae L3    20 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (38) Caffeine 25 mg/ml 48 hrs, 4-day adult  26 Paraquat 5 mM 48 hrs, 4-day adult  (37) Paraquat 10 mM 48 hrs, 4-day adult  (47) Rotenone 2 μg 12 hrs, larvae L3    21 Rotenone 8 μg 12 hrs, larvae L3  26 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    33 cold shock, 4-day adult    25 heat shock, 4-day adult    30 Cadmium 50 mM 6 hrs, larvae L3    24 Cadmium 50 mM 12 hrs, larvae L3    16 Cadmium 50 mM 48 hrs, 4-day adult    27 Cadmium 100 mM 48 hrs, 4-day adult    39 Copper 0.5 mM 12 hrs, larvae L3    30 Copper 15 mM 48 hrs, 4-day adult    15 Zinc 5 mM 12 hrs, larvae L3    21 Zinc 4.5 mM 48 hrs, 4-day adult    25 Ethanol 2.5% 3 hrs, larvae L3    41 Ethanol 5% 3 hrs, larvae L3    23 Ethanol 10% 3 hrs, larvae L3    24 Caffeine 1.5 mg/ml 4 hrs, larvae L3    20 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    38 Caffeine 25 mg/ml 48 hrs, 4-day adult    26 Paraquat 5 mM 48 hrs, 4-day adult    37 Paraquat 10 mM 48 hrs, 4-day adult    47 Rotenone 2 μg 12 hrs, larvae L3    21 Rotenone 8 μg 12 hrs, larvae L3    26 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    33 cold shock, 4-day adult    25 heat shock, 4-day adult    30 Cadmium 50 mM 6 hrs, larvae L3    24 Cadmium 50 mM 12 hrs, larvae L3    16 Cadmium 50 mM 48 hrs, 4-day adult    27 Cadmium 100 mM 48 hrs, 4-day adult    39 Copper 0.5 mM 12 hrs, larvae L3    30 Copper 15 mM 48 hrs, 4-day adult    15 Zinc 5 mM 12 hrs, larvae L3    21 Zinc 4.5 mM 48 hrs, 4-day adult    25 Ethanol 2.5% 3 hrs, larvae L3    41 Ethanol 5% 3 hrs, larvae L3    23 Ethanol 10% 3 hrs, larvae L3    24 Caffeine 1.5 mg/ml 4 hrs, larvae L3    20 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    38 Caffeine 25 mg/ml 48 hrs, 4-day adult    26 Paraquat 5 mM 48 hrs, 4-day adult    37 Paraquat 10 mM 48 hrs, 4-day adult    47 Rotenone 2 μg 12 hrs, larvae L3    21 Rotenone 8 μg 12 hrs, larvae L3    26 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    33 cold shock, 4-day adult    25 heat shock, 4-day adult    30 Cadmium 50 mM 6 hrs, larvae L3    24 Cadmium 50 mM 12 hrs, larvae L3    16 Cadmium 50 mM 48 hrs, 4-day adult    27 Cadmium 100 mM 48 hrs, 4-day adult    39 Copper 0.5 mM 12 hrs, larvae L3    30 Copper 15 mM 48 hrs, 4-day adult    15 Zinc 5 mM 12 hrs, larvae L3    21 Zinc 4.5 mM 48 hrs, 4-day adult    25 Ethanol 2.5% 3 hrs, larvae L3    41 Ethanol 5% 3 hrs, larvae L3    23 Ethanol 10% 3 hrs, larvae L3    24 Caffeine 1.5 mg/ml 4 hrs, larvae L3    20 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    38 Caffeine 25 mg/ml 48 hrs, 4-day adult    26 Paraquat 5 mM 48 hrs, 4-day adult    37 Paraquat 10 mM 48 hrs, 4-day adult    47 Rotenone 2 μg 12 hrs, larvae L3    21 Rotenone 8 μg 12 hrs, larvae L3    26 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (33) cold shock, 4-day adult    25 heat shock, 4-day adult  30 Cadmium 50 mM 6 hrs, larvae L3    24 Cadmium 50 mM 12 hrs, larvae L3    16 Cadmium 50 mM 48 hrs, 4-day adult  27 Cadmium 100 mM 48 hrs, 4-day adult  (39) Copper 0.5 mM 12 hrs, larvae L3  30 Copper 15 mM 48 hrs, 4-day adult    15 Zinc 5 mM 12 hrs, larvae L3    21 Zinc 4.5 mM 48 hrs, 4-day adult    25 Ethanol 2.5% 3 hrs, larvae L3  (41) Ethanol 5% 3 hrs, larvae L3    23 Ethanol 10% 3 hrs, larvae L3    24 Caffeine 1.5 mg/ml 4 hrs, larvae L3    20 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (38) Caffeine 25 mg/ml 48 hrs, 4-day adult  26 Paraquat 5 mM 48 hrs, 4-day adult  (37) Paraquat 10 mM 48 hrs, 4-day adult  (47) Rotenone 2 μg 12 hrs, larvae L3    21 Rotenone 8 μg 12 hrs, larvae L3  26 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    33 cold shock, 4-day adult    25 heat shock, 4-day adult    30 Cadmium 50 mM 6 hrs, larvae L3    24 Cadmium 50 mM 12 hrs, larvae L3    16 Cadmium 50 mM 48 hrs, 4-day adult    27 Cadmium 100 mM 48 hrs, 4-day adult    39 Copper 0.5 mM 12 hrs, larvae L3    30 Copper 15 mM 48 hrs, 4-day adult    15 Zinc 5 mM 12 hrs, larvae L3    21 Zinc 4.5 mM 48 hrs, 4-day adult    25 Ethanol 2.5% 3 hrs, larvae L3    41 Ethanol 5% 3 hrs, larvae L3    23 Ethanol 10% 3 hrs, larvae L3    24 Caffeine 1.5 mg/ml 4 hrs, larvae L3    20 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    38 Caffeine 25 mg/ml 48 hrs, 4-day adult    26 Paraquat 5 mM 48 hrs, 4-day adult    37 Paraquat 10 mM 48 hrs, 4-day adult    47 Rotenone 2 μg 12 hrs, larvae L3    21 Rotenone 8 μg 12 hrs, larvae L3    26 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    33 cold shock, 4-day adult    25 heat shock, 4-day adult    30 Cadmium 50 mM 6 hrs, larvae L3    24 Cadmium 50 mM 12 hrs, larvae L3    16 Cadmium 50 mM 48 hrs, 4-day adult    27 Cadmium 100 mM 48 hrs, 4-day adult    39 Copper 0.5 mM 12 hrs, larvae L3    30 Copper 15 mM 48 hrs, 4-day adult    15 Zinc 5 mM 12 hrs, larvae L3    21 Zinc 4.5 mM 48 hrs, 4-day adult    25 Ethanol 2.5% 3 hrs, larvae L3    41 Ethanol 5% 3 hrs, larvae L3    23 Ethanol 10% 3 hrs, larvae L3    24 Caffeine 1.5 mg/ml 4 hrs, larvae L3    20 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    38 Caffeine 25 mg/ml 48 hrs, 4-day adult    26 Paraquat 5 mM 48 hrs, 4-day adult    37 Paraquat 10 mM 48 hrs, 4-day adult    47 Rotenone 2 μg 12 hrs, larvae L3    21 Rotenone 8 μg 12 hrs, larvae L3    26 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_26 mE1_20_mRNA_expression_cluster_05
External Data & Images
Linkouts	BDGP expression data • LD30375 SD15168 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003654 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG18000-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal (with sw1) sw2 sw5 sw6 sw7 lethal (with sw2) sw1 lethal (with sw5) sw1 lethal (with sw6) sw1 lethal (with sw7) sw1 lethal | heat sensitive (with Df(1)mal3) sw1 lethal | larval stage | recessive swDic-1 swDic-2 swDic-3 lethal | pupal stage (with sw1) sw15 lethal | pupal stage (with sw15) sw1 lethal | recessive sw14 sw20-14 swM108 swM123 swM132 swM154 swM155 swM206 swM233 swT126 lethal | recessive | second instar larval stage sw1229 partially lethal - majority die | pupal stage, with Scer\GAL4pnr-MD237 swGD17212 viable sw1 Sterility Allele female sterile sw16 fertile | reduced sw1 Other Phenotypes Allele neuroanatomy defective | larval stage (with sw1) sw1229 neuroanatomy defective | larval stage (with sw1229) sw1 paralytic | larval stage swDic-2 visible sw1 visible, with Scer\GAL4pnr-MD237 swGD17212 visible (with sw1) swDic-1 swDic-2 swDic-3 visible (with swDic-1) sw1 visible (with swDic-2) sw1 visible (with swDic-3) sw1 wild-type sw+t11 Phenotype manifest in Allele cystic bulge sw1 dendritic arborizing neuron (with sw1) sw1229 dendritic arborizing neuron (with sw1229) sw1 eye sw1 mesothoracic tergum, with Scer\GAL4pnr-MD237 swGD17212 nucleus & spermatid sw1 ommatidium sw1 wing sw1 sw16 wing (with sw1) swDic-1 swDic-2 swDic-3 wing (with swDic-1) sw1 wing (with swDic-2) sw1 wing (with swDic-3) sw1 wing margin sw1 wing vein sw1 sw16
Classical Alleles ( 32 )
For All Classical Alleles Show
Allele of sw Class Mutagen Stocks Known lesion sw1 3 -- sw20-14 spontaneous 1 -- swe04527 piggyBac transposase 1 -- swKG05547 1 -- sw+ 0 -- sw10 ethyl methanesulfonate 0 -- sw11 ethyl methanesulfonate 0 -- sw1229 ethyl methanesulfonate 0 -- sw12 ethyl methanesulfonate 0 -- sw13 ethyl methanesulfonate 0 -- sw14 neutrons 0 -- sw15 spontaneous 0 -- sw16 spontaneous 0 -- sw2 X ray 0 -- sw3 X ray 0 -- sw4 X ray 0 -- sw5 ethyl methanesulfonate 0 -- sw6 ethyl methanesulfonate 0 -- sw7 ethyl methanesulfonate 0 -- sw8 ethyl methanesulfonate 0 -- sw9 ethyl methanesulfonate 0 -- swDic-1 ethyl methanesulfonate 0 -- swDic-2 ethyl methanesulfonate 0 -- swDic-3 ethyl methanesulfonate 0 -- swM108 methyl methanesulfonate 0 -- swM123 methyl methanesulfonate 0 -- swM132 methyl methanesulfonate 0 -- swM154 methyl methanesulfonate 0 -- swM155 methyl methanesulfonate 0 -- swM206 methyl methanesulfonate 0 -- swM233 methyl methanesulfonate 0 -- swT126 methyl methanesulfonate 0 --
Alleles Carried on Transgenic Constructs ( 13 )
For All Alleles Carried on Transgenic Constructs Show
Allele of sw Class Mutagen Stocks Known lesion swGD17212 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes swHM05249 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes swKK109087 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes sw+t11 in vitro construct - genomic fragment 0 Yes sw1a.T:Avic\GFP in vitro construct - coding region fusion 0 Yes sw1c.T:Avic\GFP in vitro construct - coding region fusion 0 Yes sw2a.T:Avic\GFP in vitro construct - coding region fusion 0 Yes sw2b.T:Avic\GFP in vitro construct - coding region fusion 0 Yes sw2c.T:Avic\GFP in vitro construct - coding region fusion 0 Yes swdsRNA.cMa in vitro construct - RNAi 0 Yes swN-2b.T:Avic\GFP in vitro construct - coding region fusion 0 Yes swN-2c.T:Avic\GFP in vitro construct - coding region fusion 0 Yes swNIG.18000R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(1)17-25 (Munoz, 2004.1.5) Df(1)18-36 (Munoz, 2004.1.5) Df(1)228 (Paradi et al., 1983) Df(1)BSC586 (Cook et al., 2008.9.3) Df(1)BSC587 (Cook et al., 2008.9.3) Df(1)BSC648 (Christensen et al., 2008.10.20) Df(1)BSC872 (Cook and Cook, 2010.2.17) Df(1)D5 (Eeken et al., 1985) Df(1)HF396 (Craymer and Roy, 1980) Df(1)HM44 (Kramers et al., 1983, Miklos et al., 1986) Df(1)mal3 (Boylan and Hays, 2002, Chovnick et al., 1969, Kramers et al., 1983, Kramers et al., 1991, Schalet and Finnerty, 1968) Df(1)mal4 (Chovnick et al., 1969, Schalet and Finnerty, 1968) Df(1)mal5 (Chovnick et al., 1969, Schalet and Finnerty, 1968) Df(1)mal7 (Chovnick et al., 1969, Schalet and Finnerty, 1968) Df(1)mal8 (Schalet and Finnerty, 1968, Chovnick et al., 1969, Paradi et al., 1983, Kramers et al., 1983, Kramers et al., 1991) Df(1)mal9 (Chovnick et al., 1969) Df(1)mal10 (Schalet and Finnerty, 1968, Chovnick et al., 1969, Schalet and Lefevre, 1973, Paradi et al., 1983, Schalet and Finnerty, 1968) Df(1)mal11 (Chovnick et al., 1969, Schalet and Finnerty, 1968) Df(1)mal12 (Chovnick et al., 1969, Paradi et al., 1983) Df(1)mal17 (Chovnick et al., 1969) Dp(1;Y)y+mal107 (Chovnick et al., 1969) Dp(1;Y)y+mal108 (Chovnick et al., 1969) Dp(1;Y)y+mal113 (Chovnick et al., 1969) Dp(1;Y)y+mal126 (Chovnick et al., 1969)
Duplicated in	Dp(1;f)3 (Schalet and Finnerty, 1968) Dp(1;f)52 (Schalet and Finnerty, 1968) Dp(1;Y)mal+   Dp(1;Y)y+mal113 (Schalet and Finnerty, 1968) Dp(1;Y)y+mal126 (Schalet and Finnerty, 1968) Dp(1;Y)y+mal+ (Lefevre, 1981, Eeken et al., 1985)
Not disrupted in	Df(1)16-2-5 (Munoz, 2004.1.5) Df(1)16-3-35 (Paradi et al., 1983, Kramers et al., 1983, Eeken et al., 1985, Kramers et al., 1991) Df(1)16-129 (Eeken et al., 1985) Df(1)17-137 (Kramers et al., 1991) Df(1)120 (Paradi et al., 1983) Df(1)127 (Paradi et al., 1983) Df(1)136 (Paradi et al., 1983) Df(1)156 (Paradi et al., 1983) Df(1)167 (Paradi et al., 1983) Df(1)208 (Paradi et al., 1983) Df(1)216 (Paradi et al., 1983) Df(1)217 (Paradi et al., 1983) Df(1)218 (Paradi et al., 1983) Df(1)A118 (Paradi et al., 1983, Eeken et al., 1985, Kramers et al., 1991) Df(1)D43L1 (Schalet and Finnerty, 1968, Paradi et al., 1983, Eeken et al., 1985, Kramers et al., 1991) Df(1)DCB1-35c (Schalet and Finnerty, 1968) Df(1)HM45 (Kramers et al., 1983) Df(1)mal6 (Schalet and Finnerty, 1968, Chovnick et al., 1969, Paradi et al., 1983, Kramers et al., 1983, Kramers et al., 1991) Df(1)mal13 (Schalet and Finnerty, 1968, Chovnick et al., 1969) Df(1)Q539 (Paradi et al., 1983, Kramers et al., 1991) Df(1)Sp20A-F (Schalet, 1986) Df(1)su(f)4B (Kramers et al., 1991) Df(1)T100 (Paradi et al., 1983) Df(1)T101 (Paradi et al., 1983) Df(1)T103 (Paradi et al., 1983) Df(1)T105 (Paradi et al., 1983) Df(1)T106 (Paradi et al., 1983) Df(1)T107 (Paradi et al., 1983) Df(1)T110 (Paradi et al., 1983) Df(1)T113 (Paradi et al., 1983) Df(1)T114 (Paradi et al., 1983) Df(1)T122 (Paradi et al., 1983) Df(1)T123 (Paradi et al., 1983) Df(1)T124 (Paradi et al., 1983) Df(1)T130 (Paradi et al., 1983) Df(1)T136 (Paradi et al., 1983) Df(1)T137 (Paradi et al., 1983) Df(1)T138 (Paradi et al., 1983) Df(1)y-X15 (Kramers et al., 1991) Dp(1;Y)su(f)-   Dp(1;Y)y+mal118 (Chovnick et al., 1969)
Not duplicated in	Dp(1;Y)59k9-4 (Eeken et al., 1985) Dp(1;Y)BS (Kramers et al., 1991) Dp(1;Y)y267g19.1 (Eeken et al., 1985) Dp(1;Y)y+mal102 (Chovnick et al., 1969) Dp(1;Y)y+mal126 (Kramers et al., 1991)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD17212} NA P{GD17549} NA P{KK109087} NA P{NIG.18000R} NA P{TRiP.HM05249} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{SUPor-P}swKG05547 NA PBac{RB}swe04527 NA
Gene Ontology: Function, Process & Cellular Component ( 12 unique terms )
Terms Based on Experimental Evidence ( 10 terms )
Molecular Function
CV term Evidence References
dynein light chain binding inferred from physical interaction with ctp (Song et al., 2007) inferred from physical interaction with Dlc90F (Song et al., 2007)
Biological Process
CV term Evidence References
axon cargo transport inferred from mutant phenotype (Zheng et al., 2008) centrosome localization inferred from mutant phenotype (Morales-Mulia and Scholey, 2005) cytoplasmic transport inferred from mutant phenotype (Serbus et al., 2005) eye photoreceptor cell differentiation inferred from genetic interaction with Gl (Whited et al., 2004) microtubule cytoskeleton organization inferred from mutant phenotype (Zheng et al., 2008) protein localization to kinetochore inferred from mutant phenotype (Dzhindzhev et al., 2005) sperm individualization inferred from mutant phenotype (Ghosh-Roy et al., 2005) spindle organization inferred from mutant phenotype (Morales-Mulia and Scholey, 2005)
Cellular Component
CV term Evidence References
microtubule associated complex inferred from direct assay (Hughes et al., 2008)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
microtubule motor activity non-traceable author statement (Swiss-Prot Project Members, 1997.2.1)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
cytoplasmic dynein complex inferred from electronic annotation with InterPro:IPR025956 (FlyBase Curators et al., 2004-) non-traceable author statement (Benevolenskaya, 1995)
Sequence Ontology: Class of Gene
	gene_with_edited_transcript (Graveley et al., 2011) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
sw - Arr1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sw - Bsg anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sw - CG11791 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sw - CG13950 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sw - CG14020 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sw - CG17121 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sw - CG18787 experimental knowledge based (Guruharsha et al., 2011) sw - CG2010 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sw - CG2616 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sw - CG32236 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sw - CG3238 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sw - CG32698 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sw - CG3819 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sw - CG4866 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sw - CG7456 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sw - CG8199 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sw - CG8888 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sw - CG9331 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sw - Ctr1B anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sw - Dhc64C anti bait coimmunoprecipitation, western blot, cosedimentation (Mische et al., 2008) sw - Dlc90F anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sw - Dlic cosedimentation, western blot, anti bait coimmunoprecipitation (Mische et al., 2008) sw - Faf anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sw - Gl nuclear magnetic resonance (Morgan et al., 2011) sw - Jon99Ci anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sw - Prosα7 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sw - Sap47 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sw - Spn47C anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sw - Uev1A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sw - ana2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sw - dpr14 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sw - fwe anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sw - robl experimental knowledge based (Guruharsha et al., 2011) sw - tef anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions sw allele Gene References sw1 Gl (Boylan and Hays, 2002) sw+t11 Gl (Boylan et al., 2000) swDic-1 Gl (Boylan and Hays, 2002) swDic-2 Gl (Boylan and Hays, 2002, Whited et al., 2004) swDic-3 Gl (Boylan and Hays, 2002)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 68871 DroID - A comprehensive database of gene and protein interactions. • FBgn0003654 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 44160 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q24246
Orthologs
OrthoDB Orthologs (50) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6XPR1H Dipteran inclusive ortholog search EOG6QJRWD Insect inclusive ortholog search EOG69GJBP Arthropod inclusive ortholog search EOG61C5BB Metazoa inclusive ortholog search EOG6H4JWS
Orthologs in Drosophila Species (EOG6XPR1H)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Sdic1     Drosophila melanogaster fruit fly  Dmel\Sdic2     Drosophila melanogaster fruit fly  Dmel\sw     Drosophila melanogaster fruit fly  Dmel\Sdic3     Drosophila simulans   Dsim\GD22919   Y Drosophila sechellia   Dsec\GM22686   Y Drosophila erecta   Dere\GG18006   Y Drosophila yakuba   Dyak\GE15363   Y Drosophila ananassae   Dana\GF20447   Y Drosophila pseudoobscura pseudoobscura   Dpse\GA22798   Y Drosophila persimilis   Dper\GL12916   Y Drosophila willistoni   Dwil\GK25594   Y Drosophila virilis   Dvir\GJ15778   Y Drosophila mojavensis   Dmoj\GI11093   Y Drosophila grimshawi   Dgri\GH12086   Y
Orthologs in non-Drosophila Dipterans (EOG6QJRWD)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL012234 Y Anopheles gambiae Malaria mosquito  Agam\AGAP000320 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ802236 Y
Orthologs in non-Dipteran Insects (EOG69GJBP)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB45923 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG012254 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH18569 Y Atta cephalotes Leafcutter ant  Acep\ACEP25655 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO16869 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL16352 Y Linepithema humile Argentine ant  Lhum\LH14174 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB15068 Y Solenopsis invicta Red fire ant  Sinv\SINV18538 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI000987 Y Bombyx mori Silkmoth  Bmor\BGIBMGA002375 Y Pediculus humanus Human body louse  Phum\PHUM004610 Y Tribolium castaneum Red flour beetle  Tcas\TC011326 Y
Orthologs in non-Insect Arthropods (EOG61C5BB)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_211388 Y Ixodes scapularis Deer tick  Isca\ISCW020745 Y
Orthologs in non-Arthropod Metazoa (EOG6H4JWS)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\dyci-1 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_022687gn Y Danio rerio Zebrafish  Drer\dync1i1 Y Danio rerio Zebrafish  Drer\dync1i2b Y Danio rerio Zebrafish  Drer\dync1i2a Y Danio rerio Zebrafish  Drer\ENSDARG00000022487 Y Danio rerio Zebrafish  Drer\ENSDARG00000078386 Y Xenopus tropicalis Western clawed frog  Xtro\dync1i1 Y Xenopus tropicalis Western clawed frog  Xtro\dync1i2 Y Gallus gallus Domestic chicken  Ggal\DYNC1I2 Y Gallus gallus Domestic chicken  Ggal\DYNC1I1 Y Mus musculus House mouse  Mmus\Dync1i1 Y Mus musculus House mouse  Mmus\Dync1i2 Y Rattus norvegicus Norway rat  Rnor\Dync1i1 Y Rattus norvegicus Norway rat  Rnor\Dync1i2 Y Homo sapiens Human  Hsap\ENSG00000077380 Y Homo sapiens Human  Hsap\ENSG00000158560 Y
Human Orthologs (2)
Gene OMIM HGNC Hsap\ENSG00000077380     Hsap\ENSG00000158560
AAA Orthologs (0) based on analysis using Dmel annotation version 4.3
No orthologs identified
Stocks & Reagents
Stocks Listed in FlyBase ( 10 )
Bloomington	4175 sw1 13899 y1 P{SUPor-P}swKG05547/FM7c 30505 y1 sc* v1; P{TRiP.HM05249}attP2 175 y1 pn1 w1 cm1 ct6 sn3 oc1 ras2 v1 dy1 g2 f1 oso car1 sw1/In(1)scS1, In(1)dl-49, yc4 scS1 vOf B1
Harvard	- PBac{RB}swe04527
Kyoto	108392 mei-9a sw20-14/FM7c, ctS 105772 y1 pn1 w1 cm1 ct6 sn3 oc1 ras2 v1 dy1 g2 f1 oso car1 sw1/In(1)scS1, In(1)dl-49, yc4 scS1 vOf B1
VDRC	v101559 P{KK109087}VIE-260B v48333 w1118; P{GD17212}v48333 v48334 w1118; P{GD17212}v48334
Genomic Clones ( 1 )
	BACR10C18 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 224 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT13950 AT17034 GH08687 GH16657 LD22777 LD30375 LD35918 LP16352 RE02453 RH20911 SD15168 SD27396
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT01927 AT03643 AT07009 AT13301 AT18086 AT27463 GH02760 GH05012 GH11339 GH16652 GH21661 GH27655 GM04415 GM09869 GM13350 HL07730 LD15330 LD25903 LD30162 LD31758 LD31760 LD38540 LD39953 LD42953 LD43893 LD43953 LD44384 LP14645 RE04791 RE12870 RE16607 RE17857 RE22003 RE24073 RE24090 RE25093 RE30710 RE43165 RE52361 RE58568 RE65217 RE65229 RE67450 RE72903 RH03761 RH07767 RH07971 RH12010 RH23370 RH41344 RH51607 RH67832 SD03773 SD05560 SD07145 SD07844 SD09658 SD16761 SD17733 SD17855 SD18911 SD22748 UT01049
Other clones	8481 31519 40564 71026 72670 77028 77060 80055 83224 118383 123664 149535 158414 161833 163434 163551 175742 194404 214289.63 214545.64 272623 AM02247 CK01.5D.E5 CK01.24B.H3 CK01.32A.D12 CK01.54D.D3 CK01.64B.H6 CK01.102B.G12 CK01.168D.G9 Dmel_dig_003574_0589_2447 Dmel_dig_012691_0639_1183 EC051823 EK027548 EK044414 EK052248 EK065063 EK086258 EK103725 EK106840 EK141546 EK142605 EK153659 EK166908 EK174339 EK199960 EK212440 EK216743 EK225309 EK237351 EK246534 EK255354 EK261510 EK266072 EK267631 EK267964 EK280036 EK297256 EP03206 EP10458 EP12538 EP12826 IP14368 RP004019479 RP004030933 RP004048288 RP004051514 RP004059203 RP004074245 RP004075945 RP004079472 RP004084183 RP004111976 RP004116247 RP004124552 RP004125771 RP004131949 RP004132780 RP004142523 RP004164012 RP004167371 RP004177414 RP004182844 RP004184914 RP004188871 RP004192296 RP004195661 RP004196625 RP004197230 RP004200580 RP004204804 RP004208939 RP004212150 RP004212332 RP004214463 RP004216831 RP004219001 RP004220200 RP004221775 RP004223603 RP004224814 RP004224931 RP004226742 RP004230371 RP004232213 RP004243054 RP004243130 RP004246792 RP004246896 RP004261231 RP004262061 RP004262454 RP004266708 RP004282654 RP004285166 RP004285975 RP004298261 RP004312137 RP004312550 RP004314156 RP004319373 RP004325522 RP004347590 RP004367053 RP004375998 RP004395879 RP004403182 RP004404165 RP004404456 RP004405300 RP004408583 RP004417717 RP004427312 RP004434147 RP004439455 RP004442218 RP004455126 RP004465571 RP004465795 RP004468195 RP004474754 RP004477014 RP004477649 RP004477676 RP004482722 RP004503881 RP004508348 RP004546220 RP004549447 RP004550217
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0003654 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 44160
Antibody Information
Other Information
Discoverer
	Eker, 12th Jan. 1932.
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Cdic CG18000 (Bayraktaroglu, 2000.4.12) Source for merge of: sw Cdic (Boylan and Hays, 2002)
Additional comments	The proximity of "Su(Gl)27" to "sw", together with the nature of the Gl product suggests that "Su(Gl)27" and "sw" may be the same gene. (Benevolenskaya et al., 1995) Either this is a complex locus with sw4 being the only noncomplementing allele or sw4 is a double mutant and there are two loci. Numerous lethal alleles at this locus recovered from line containing a P element in 19C (Simmons, Raymond, Johnson, and Fahey, 1984).
Other Comments
	sw is required for polarised dendritic transport and uniform microtubule orientation in axons. (Zheng et al., 2008)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057721 NM_057722 NM_057723 NM_057724 NM_057725 NM_057726 NM_057727 NM_057728 NM_057729 NM_057730 NM_057731 NM_206798 NM_206799 RefSeq (Proteins) • NP_477069 NP_477070 NP_477071 NP_477072 NP_477073 NP_477074 NP_477075 NP_477076 NP_477077 NP_477078 NP_477079 NP_996521 NP_996522 DDBJ / EMBL / GenBank • AAB51185 AAC70933 AAC70934 AAC70935 AAC70936 AAC70937 AAC70938 AAC70939 AAC70940 AAC70941 AAC70942 AAC70943 AAC78306 AAF50928 AAF73046 AAM50816 AAN09553 AAN09554 AAN09555 AAN09556 AAN09557 AAN09558 AAN09559 AAN09560 AAN09561 AAN09562 AAS65417 AAS65418 AAV36986 AF070687 AF070689 AF070690 AF070691 AF070692 AF070693 AF070694 AF070695 AF070696 AF070697 AF070698 AF070699 AF263371 AI456082 AY118956 BT016101 CZ482278 L41945 Z32429 Z32430 Entrez Gene - A searchable database of RefSeq genes. • 44160 UniProtKB/Swiss-Prot • Q24246 UniProtKB/TrEMBL • A4V4T4 Q8MSA9
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • WD40/YVTN repeat-like-containing domain (IPR015943) WD40-repeat-containing domain (IPR017986) WD40 repeat (IPR001680) Cytoplasmic dynein 1 intermediate chain 1/2 (IPR025956) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD30375 SD15168
Linkouts
	BioGRID - A database of protein and genetic interactions • 68871 DroID - A comprehensive database of gene and protein interactions. • FBgn0003654 DRSC - Results from RNAi screens. • FBgn0003654 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003654 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG18000-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0003654 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 44160 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 44160 modMine - Data generated by the modENCODE project. • FBgn0003654 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q24246
Synonyms & Secondary IDs ( 30 )
Reported As
Symbol Synonym	17-234 (Munoz, 2004.1.5, Kramers et al., 1991, Kramers et al., 1983, Paradi et al., 1983) Cdic (Welte et al., 2005, Duncan and Warrior, 2002, King et al., 2002.9.23, Brookfield, 2001, Iida and Akashi, 2000, Nurminsky et al., 2001, Goldstein and Gunawardena, 2000, Wojcik and Hays, 1999, Nurminsky and Hartl, 1999, Charlesworth and Charlesworth, 1999, Nurminsky and Hartl, 1998, Nurminsky et al., 1998, Capy, 1998, Nurminsky et al., 1998, Benevolenskaya et al., 1995, Giot et al., 2003, Ponce and Hartl, 2006, Metcalf and Wassarman, 2006, Ghosh-Roy et al., 2005, Ponce, 2007, Ponce, 2009, Anderson et al., 2009, Liebl and Featherstone, 2005) cDIC (Nurminsky et al., 1997) Cdic2b (Morgan et al., 2011, Nyarko et al., 2012) CG18000 (Whitfield, 2001.1.18, Morales-Mulia and Scholey, 2005, Perkins et al., 2009, Ida et al., 2009, Keleman et al., 2009.8.5, Hughes et al., 2008, Zhan et al., 2011) DIC (Serbus et al., 2005, Gunawardena et al., 2003, Harris and Peifer, 2005, Haghnia et al., 2007, Riggs et al., 2007, Loiseau et al., 2010, Dickman et al., 2012) dic (Whited et al., 2004, Zheng et al., 2008, Reis et al., 2012, Lloyd et al., 2012, Dickman et al., 2012) Dic (Gross et al., 2000, Boylan and Hays, 1999, Boylan and Hays, 1998, Boylan and Hays, 1999, Boylan and Hays, 1998, Bullock et al., 2006, Hampoelz et al., 2011, Dzhindzhev et al., 2005, Mische et al., 2008, Lerit and Gavis, 2011) Dic19B (Boylan, 2000.5.3) Dic19C (Boylan and Hays, 2002, Fatima, 2011) IC (Boylan et al., 2000, Morales-Mulia and Scholey, 2005, Song et al., 2007, Hall et al., 2009, Nyarko et al., 2004, Benison et al., 2007, Morgan et al., 2011, Nyarko et al., 2012) IC74 (Makokha et al., 2002, Akbar et al., 2009) l(1)19Bb   sw (Cook et al., 2008.9.3, Cook et al., 2008.9.3, Ghosh-Roy et al., 2005, Christensen et al., 2008.10.20, Ida et al., 2009, Cook and Cook, 2010.2.17, Xiong et al., 2010, Japanese National Institute of Genetics, 2012.5.21, Yeh et al., 2012)
Name Synonym	Cytoplasmic dynein (Welte, 2004) cytoplasmic dynein (de Heredia and Jansen, 2004, Leidel et al., 2012) Cytoplasmic dynein intermediate chain   cytoplasmic dynein intermediate chain (Song et al., 2007, Nyarko et al., 2004) cytoplasmic dynein intermediate polypeptide chain (Ponce, 2007) dynein (Kalinovsky and Scheiffele, 2004, Zheng et al., 2008, Kuznetsov, 2011) dynein IC (Mische et al., 2008, Reis et al., 2012) Dynein IC (Nyarko and Barbar, 2011) Dynein intermediate chain (Harris and Peifer, 2005) dynein intermediate chain (Haghnia et al., 2007, Zheng et al., 2008, Loiseau et al., 2010, Benison et al., 2007, Morgan et al., 2011) Dynein intermediate-chain (Riggs et al., 2007) dynein intermediate-chain (Dzhindzhev et al., 2005) Dynein Intermediate chain (Dickman et al., 2012) Dynein Intermediate Chain (Dickman et al., 2012) short wing (Zheng et al., 2008, Fisher et al., 2008) Swallow (Nyarko and Barbar, 2011)
Secondary FlyBase IDs
	FBgn0013761 FBgn0031096
References ( 125 )
Generate a list of	All references relating to this gene ( 125 )
List References by type	Research paper  ( 73 ) Supplementary material  ( 7 ) Review  ( 6 ) Personal communication to FlyBase  ( 17 ) Abstract  ( 11 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 3 ) Letter  ( 2 ) Stock list  ( 1 ) Protein sequence record  ( 1 ) Website  ( 1 ) Book  ( 1 )
Recent research papers ( 13 )
	Dickman et al., 2012, J. Neurosci. 32(25): 8716--8724 Snapin is Critical for Presynaptic Homeostatic Plasticity. [FBrf0218676] Leidel et al., 2012, Biophys. J. 103(3): 492--500 Measuring Molecular Motor Forces In Vivo: Implications for Tug-of-War Models of Bidirectional Transport. [FBrf0219402] Lloyd et al., 2012, Neuron 74(2): 344--360 The p150(Glued) CAP-Gly Domain Regulates Initiation of Retrograde Transport at Synaptic Termini. [FBrf0218160] Nyarko et al., 2012, J. Biol. Chem. 287(30): 24884--24893 Intrinsic disorder in dynein intermediate chain modulates its interactions with NudE and dynactin. [FBrf0219795] Reis et al., 2012, Mol. Biol. Cell 23(9): 1700--1714 Molecular motor function in axonal transport in vivo probed by genetic and computational analysis in Drosophila. [FBrf0218178] Yeh et al., 2012, Proc. Natl. Acad. Sci. U.S.A. 109(6): 2043--2048 Functional evidence that a recently evolved Drosophila sperm-specific gene boosts sperm competition. [FBrf0217456] Fatima, 2011, PLoS ONE 6(12): e27822 Drosophila Dynein Intermediate Chain Gene, Dic61B, Is Required for Spermatogenesis. [FBrf0216864] Hampoelz et al., 2011, Development 138(16): 3377--3386 Microtubule-induced nuclear envelope fluctuations control chromatin dynamics in Drosophila embryos. [FBrf0214526] Kuznetsov, 2011, Comput. Methods. Biomech. Biomed. Engin. 14(12): 1117--1131 Modelling active transport in Drosophila unipolar motor neurons. [FBrf0216800] Lerit and Gavis, 2011, Curr. Biol. 21(6): 439--448 Transport of germ plasm on astral microtubules directs germ cell development in Drosophila. [FBrf0213255] Morgan et al., 2011, J. Biol. Chem. 286(45): 39349--39359 Structural dynamics and multiregion interactions in dynein-dynactin recognition. [FBrf0217083] Nyarko and Barbar, 2011, J. Biol. Chem. 286(2): 1556--1566 Light chain-dependent self-association of dynein intermediate chain. [FBrf0214141] Zhan et al., 2011, Gene 470(1-2): 1--6 Evolution of alternative splicing in newly evolved genes of Drosophila. [FBrf0212278] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...