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General Information
Symbol
Dmel\sw
Species
D. melanogaster
Name
short wing
Annotation Symbol
CG18000
Feature Type
FlyBase ID
FBgn0003654
Gene Model Status
Stock Availability
Gene Snapshot
short wing (sw) encodes the non-catalytic intermediate chain subunit of the cytoplasmic dynein motor complex. It contributes to wing development, eye development, oocyte development and polarity, mitotic cell division, and neuronal transport and neurogenesis. [Date last reviewed: 2019-03-14]
Also Known As
Cdic, Dic, IC, dynein intermediate chain, 17-234
Key Links
Genomic Location
Cytogenetic map
Sequence location
X:20,227,961..20,236,382 [-]
Recombination map
1-64
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Protein Family (UniProt)
Belongs to the dynein intermediate chain family. (Q24246)
Summaries
Gene Group (FlyBase)
CYTOPLASMIC DYNEIN INTERMEDIATE CHAINS -
Dyneins are minus end-directed microtubule motor protein complexes. Cytoplasmic dynein intermediate chains are subunits of dynein complexes. They interact with dynein cargo and link cytoplasmic dynein to dynactin. (Adapted from FBrf0214141 and PMID:24064538).
Protein Function (UniProtKB)
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the help dynein bind to dynactin 150 kDa component (By similarity).
(UniProt, Q24246)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
sw: short wing
thumb
sw: short wing
From Eker, 1935, J. Genet. 30: 357-68.
Above 23, most sw1 flies have spread and incised wings with irregular veins; eyes reduced and roughened. Male expression more extreme than female. 15% of males eclose at 25; show wing and eye abnormalities (Schalet, 1969, DIS 43: 128); above 31, sw is lethal. At 17, most flies are wild type; at 14, all are wild type. +/Df(1)mal10 and +/sw exhibit short-wing phenotype in presence of RpII215Ubl (Mortin and Lefevre, 1981, Chromosoma 82: 237-47). RK2 at 28.
Gene Model and Products
Number of Transcripts
15
Number of Unique Polypeptides
12

Please see the GBrowse view of Dmel\sw or the JBrowse view of Dmel\sw for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.50
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0089397
2699
634
FBtr0089398
2841
627
FBtr0089399
2838
626
FBtr0089400
2889
643
FBtr0089401
3070
642
FBtr0089402
2910
650
FBtr0089403
2868
636
FBtr0089404
2702
635
FBtr0089405
2678
627
FBtr0089406
2786
663
FBtr0089407
2756
653
FBtr0089408
3032
643
FBtr0089409
2873
643
FBtr0340360
2862
634
FBtr0340361
2889
643
Additional Transcript Data and Comments
Reported size (kB)
2.8 (northern blot)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0088419
70.2
634
5.03
FBpp0088420
69.5
627
5.09
FBpp0088421
69.4
626
5.09
FBpp0088422
71.5
643
4.82
FBpp0088423
71.4
642
4.82
FBpp0088424
72.2
650
4.78
FBpp0088425
70.6
636
4.81
FBpp0088426
70.6
635
4.81
FBpp0088427
69.4
627
5.03
FBpp0088428
73.9
663
4.91
FBpp0088429
72.9
653
4.87
FBpp0089020
71.5
643
4.82
FBpp0089021
71.5
643
4.82
FBpp0309318
70.2
634
5.03
FBpp0309319
71.4
643
4.78
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

634 aa isoforms: sw-PA, sw-PN
643 aa isoforms: sw-PD, sw-PL, sw-PM
Additional Polypeptide Data and Comments
Reported size (kDa)
653, 650, 643, 642, 636, 635, 634, 627, 626, 163 (aa)
Comments
External Data
Subunit Structure (UniProtKB)
Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs).
(UniProt, Q24246)
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\sw using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Gene Ontology (15 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
inferred from physical interaction with FLYBASE:DCTN1-p150; FB:FBgn0001108
inferred from physical interaction with FLYBASE:ctp; FB:FBgn0011760
inferred from physical interaction with FLYBASE:Dlc90F; FB:FBgn0024432
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000277823
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000277823
(assigned by GO_Central )
inferred from sequence or structural similarity with UniProtKB:P54703
inferred from biological aspect of ancestor with PANTHER:PTN000277823
(assigned by GO_Central )
Biological Process (10 terms)
Terms Based on Experimental Evidence (9 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000277823
(assigned by GO_Central )
Cellular Component (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000277824
(assigned by GO_Central )
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
organism

Comment: maternally deposited

northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
"Cdic1a" is one of the major forms of Cdic mRNA expressed in the fly. It is constitutively expressed and together with "Cdic2a" and "Cdic2b" makes up over 70% if the Cdic mRNA in adults, embryos and all tested body parts.
"Cdic5a" is a minor form of Cdic mRNA which is up-regulated in the head and to a lesser extent in the torso.
"Cdic5b" is a minor form of Cdic mRNA which is up-regulated in the head and to a lesser extent in the torso.
"Cdic1b" is a minor form of Cdic mRNA which is up-regulated in the ovary.
"Cdic1c" is a minor form of Cdic mRNA which is up-regulated in the ovary.
"Cdic2a" is one of the major forms of Cdic mRNA expressed in the fly. It is constitutively expressed and together with "Cdic1a" and "Cdic2b" makes up over 70% if the Cdic mRNA in adults, embryos and all tested body parts.
"Cdic2b" is one of the major forms of Cdic mRNA expressed in the fly. It is constitutively expressed and together with "Cdic1a" and "Cdic2a" makes up over 70% if the Cdic mRNA in adults, embryos and all tested body parts.
"Cdic2c" is a minor form of Cdic mRNA which is constitutively expressed at a low level.
"Cdic3a" is a minor form of Cdic mRNA which is up-regulated in the ovary.
"Cdic3b" is a minor form of Cdic mRNA which is up-regulated in the ovary.
"Cdic4" is a minor form of Cdic mRNA which is up-regulated in the ovary.
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\sw in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 32 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of sw
Transgenic constructs containing regulatory region of sw
Deletions and Duplications ( 73 )
Not disrupted in
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal (with sw2)
lethal (with sw5)
lethal (with sw6)
lethal (with sw7)
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
nucleus & spermatid
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (6)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
14 of 15
Yes
Yes
13 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (7)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
14 of 15
Yes
Yes
13 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Rattus norvegicus (Norway rat) (6)
13 of 13
Yes
Yes
11 of 13
No
Yes
1 of 13
No
No
1 of 13
No
No
1 of 13
No
Yes
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (2)
8 of 12
Yes
Yes
4 of 12
No
Yes
Danio rerio (Zebrafish) (10)
12 of 15
Yes
Yes
11 of 15
No
Yes
6 of 15
No
No
2 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (3)
13 of 15
Yes
Yes
1 of 15
No
No
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (1)
1 of 9
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (2)
1 of 15
Yes
Yes
1 of 15
Yes
No
Schizosaccharomyces pombe (Fission yeast) (1)
10 of 12
Yes
No
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091904NH )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Drosophila melanogaster
fruit fly
Drosophila melanogaster
fruit fly
Drosophila melanogaster
fruit fly
Drosophila melanogaster
fruit fly
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091502NW )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W03XU )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X03UT )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G038G )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Ciona intestinalis
Vase tunicate
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (16)
9 of 10
9 of 10
7 of 10
6 of 10
4 of 10
3 of 10
3 of 10
3 of 10
3 of 10
3 of 10
3 of 10
2 of 10
2 of 10
2 of 10
1 of 10
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser

    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    RNA-protein
    Physical Interaction
    Assay
    References
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement

    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Subunit Structure (UniProtKB)
    Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs).
    (UniProt, Q24246 )
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Gene Group - Pathway Membership (FlyBase)
    External Data
    Linkouts
    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
    SignaLink - A signaling pathway resource with multi-layered regulatory networks.
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    X
    Recombination map
    1-64
    Cytogenetic map
    Sequence location
    X:20,227,961..20,236,382 [-]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    19C1-19C1
    Limits computationally determined from genome sequence between P{EP}amnEP1639&P{EP}amnEP367 and P{EP}CG1702EP1525
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    19C-19C
    (determined by in situ hybridisation)
    19E-19E
    (determined by in situ hybridisation)
    19B-19B
    (determined by in situ hybridisation)
    Experimentally Determined Recombination Data
    Location
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (10)
    Genomic Clones (9)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (245)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequences
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    Other clones
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Antibody Information
    Laboratory Generated Antibodies
     
    Commercially Available Antibodies
     
    Other Information
    Relationship to Other Genes
    Source for database identify of
    Source for database merge of
    Source for merge of: Cdic CG18000
    Source for merge of: sw Cdic
    Additional comments
    The genes sw and Sdic1 share >70% identity and close proximity, and so may have been derived from a DNA-based tandem duplication.
    The proximity of "Su(Gl)27" to "sw", together with the nature of the Gl product suggests that "Su(Gl)27" and "sw" may be the same gene.
    Either this is a complex locus with sw4 being the only noncomplementing allele or sw4 is a double mutant and there are two loci. Numerous lethal alleles at this locus recovered from line containing a P element in 19C (Simmons, Raymond, Johnson, and Fahey, 1984).
    Other Comments
    sw is required for polarised dendritic transport and uniform microtubule orientation in axons.
    Origin and Etymology
    Discoverer
    Eker, 12th Jan. 1932.
    Etymology
    Identification
    External Crossreferences and Linkouts ( 118 )
    Sequence Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
    Other crossreferences
    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    Flygut - An atlas of the Drosophila adult midgut
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
    KEGG Genes - Molecular building blocks of life in the genomic space.
    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
    modMine - A data warehouse for the modENCODE project
    SignaLink - A signaling pathway resource with multi-layered regulatory networks.
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    DRSC - Results frm RNAi screens
    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    FlyMine - An integrated database for Drosophila genomics
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Synonyms and Secondary IDs (31)
    Reported As
    Symbol Synonym
    l(1)19Bb
    Secondary FlyBase IDs
    • FBgn0013761
    • FBgn0031096
    Datasets (0)
    Study focus (0)
    Experimental Role
    Project
    Project Type
    Title
    References (163)