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Gene Dmel\sws

General Information
Symbol	Dmel\sws	Species	D. melanogaster
Name	swiss cheese	Annotation symbol	CG2212
Feature type	protein_coding_gene	FlyBase ID	FBgn0003656
Gene Model Status	Current	Stock availability	11 publicly available
Also Known As	olfE
Genomic Location
Chromosome (arm)	X	Recombination map	1-22
Cytogenetic map	7D1-7D1	Sequence location	X:7,850,853..7,862,269 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene swiss cheese is referred to in FlyBase by the symbol Dmel\sws (CG2212, FBgn0003656). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding; lysophospholipase activity. There is experimental evidence that it is involved in the biological process: membrane lipid metabolic process; phosphatidylcholine metabolic process; cellular membrane organization; sensory perception of smell; neuron apoptotic process. 22 alleles are reported. The phenotypes of these alleles are annotated with: cortex of lamina; epithelial glial cell; CNS glial cell; neuropil; eye photoreceptor cell; adult brain. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Acyl transferase/acyl hydrolase/lysophospholipase; Cyclic nucleotide-binding domain; Cyclic nucleotide-binding-like; Lysophospholipase patatin, conserved site; Patatin/Phospholipase A2-related; RmlC-like jelly roll fold. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages, during late pupal stages, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult central nervous system, adult heart, adult fat body, adult female reproductive system, adult testis, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, larval fat body, larval/adult salivary gland, larval trachea, adult male accessory gland, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1631499_a_at completely aligns to an exonic region common to each of the 3 FlyBase-annotated transcript isoforms of sws. Gene sequence location is X:7850853..7862269.
User Contributed Data
	Beta version, feedback welcome
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	olfE: olfactory-E (J.C. Hall) Larvae and adults show reduction in responses to benzaldehyde in petri-plate-based and Y-tube olfactometric assays, respectively. In odor-induced-jump assay (using benzaldehyde), mutants jump less than half as often as normal flies. allele: There is one extant allele, olfEx26. sws: swiss cheese (J.C. Hall) Isolated in anatomical screen (cf. Heisenberg and Bohl, 1979, Z. Naturforsch. 34: 143-47); many Swiss-cheese-like holes seen in brain sections of adults (similar to phenotype observed in dying drd flies).
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 7D1-7D1   Limits computationally determined from genome sequence between P{EP}EP1243 and P{EP}snEP1217
Experimentally Determined Cytological Location
Cytogenetic map Notes References 7D-7D     (Kretzschmar et al., 1995) 7D1-7D1   (determined by in situ hybridisation)   (Hasan, 1990)
Experimentally Determined Recombination Data
Location	1-22   1-23 (Ayyub et al., 1990)
Left of (cM)	sn mys fs(1)h Tbh (Monastirioti et al., 1996) v (Ayyub et al., 1990)
Right of (cM)	cv (Ayyub et al., 1990)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\sws for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.50 Low-frequency RNA-Seq exon junction(s) not annotated. DGC clone LD36116 appears problematic: incomplete CDS
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) sws-RA FBtr0071125  NM_078520   5571   1425 sws-RB FBtr0071126  NM_167141   1771   341 sws-RC FBtr0301675  NM_167140   5571   1425
Additional Transcript Data & Comments
Reported size (kB)	5.4, 1.7 (northern blot) (Hasan, 1990)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein sws-PA   FBpp0071077   160.6   1425   7.95     NP_511075   AAF46305 sws-PB   FBpp0071078   38.8   341   4.59     NP_727225   AAN09223 sws-PC   FBpp0290889   160.7   1425   7.91     NP_727224   AAN09222
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Cyclic nucleotide-binding-like (IPR018490) Cyclic nucleotide-binding domain (IPR000595) Lysophospholipase patatin, conserved site (IPR001423) Patatin/Phospholipase A2-related (IPR002641) RmlC-like jelly roll fold (IPR014710) Acyl transferase/acyl hydrolase/lysophospholipase (IPR016035)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014298 AAF46305   AE014298 AAN09222   AE014298 AAN09223   AI109400   AI456235   AI514712   AI518304   AI543350   AI945301   AJ571482   AJ571483   AJ571484   AJ571485   AJ571486   AJ571487   AJ571488   AJ571489   AJ571490   AJ571491   AJ571492   AJ571493   AJ571494   AJ571495   AJ571496   AJ571497   AJ571498   AJ571499   AJ571500   AJ571501   AJ571502   AJ571503   AJ571504   AJ571505   AW943322   AY061431 AAL28979   AY121635   BF486613   BF499017   BG636297   BG637227   BI632666   BT030819   BT133162   CK658192   CK659052   CO192980   CO281226   CO282162   CO292471   CO293985   CO298090   CO299583   CO301901   CO305879   CO313602   CO313768   CO316724   CO324496   CO339624   CO340967   CZ475831   CZ475832   CZ489073   CZ489074   EC054581   EC062062   EC063796   EC065306   EC066000   EC073667   EC074798   EC078029   EC201621   EC212455   EC214048   EC216657   EC233750   EC234177   EC246177   EC248535   EC250543   EC254331   EL869871   EL872443   EL875263   EL875264   EL883992   EL883993   EL884108   EL884109   EL884236   EV583128   Z97187 CAB51772
UniProtKB/Swiss-Prot	Q9U969
UniProtKB/TrEMBL	E1JJF4
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Hasan, 1990) adult stage   adult head   (Hasan, 1990)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
endoplasmic reticulum membrane inferred from direct assay (assigned by UniProtKB) (Bettencourt da Cruz et al., 2008)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult central nervous system, adult heart, adult fat body, adult female reproductive system, adult testis, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, larval fat body, larval/adult salivary gland, larval trachea, adult male accessory gland, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    407.025 Larval Midgut    232.5 Larval Hindgut    243.6 Larval Malpighian Tubules    183.4 Larval Fat Body    271.2 Larval Salivary Gland    107.1 Larval Trachea    176.075 Larval Carcass    188.875 Adult Head    586 Adult Eye    390.025 Adult Brain    880 Adult Thoracic-Abdominal Ganglion    1067.9 Adult Crop    231.1 Adult Midgut    236.3 Adult Hindgut    204.2 Adult Malpighian Tubules    244.8 Adult Fat Body    1188.3 Adult Salivary Gland    152.3 Adult Heart    712.5 Adult VirginFemale Spermatheca    728.7 Adult InseminatedFemale Spermatheca    613.5 Adult Ovary    793.5 Adult Testis    816.2 Adult Male Accessory Gland    239 Adult Carcass    721.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    407.025 Larval Midgut    232.5 Larval Hindgut    243.6 Larval Malpighian Tubules    183.4 Larval Fat Body    271.2 Larval Salivary Gland    107.1 Larval Trachea    176.075 Larval Carcass    188.875 Adult Head  (586) Adult Eye    390.025 Adult Brain  (880) Adult Thoracic-Abdominal Ganglion  (1067.9) Adult Crop    231.1 Adult Midgut    236.3 Adult Hindgut    204.2 Adult Malpighian Tubules    244.8 Adult Fat Body  (1188.3) Adult Salivary Gland    152.3 Adult Heart  (712.5) Adult VirginFemale Spermatheca  (728.7) Adult InseminatedFemale Spermatheca  (613.5) Adult Ovary  (793.5) Adult Testis  (816.2) Adult Male Accessory Gland    239 Adult Carcass  (721.5) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    407.025 Larval Midgut    232.5 Larval Hindgut    243.6 Larval Malpighian Tubules    183.4 Larval Fat Body    271.2 Larval Salivary Gland    107.1 Larval Trachea    176.075 Larval Carcass    188.875 Adult Head    586 Adult Eye    390.025 Adult Brain    880 Adult Thoracic-Abdominal Ganglion  1067.9 Adult Crop    231.1 Adult Midgut    236.3 Adult Hindgut    204.2 Adult Malpighian Tubules    244.8 Adult Fat Body  (1188.3) Adult Salivary Gland    152.3 Adult Heart    712.5 Adult VirginFemale Spermatheca    728.7 Adult InseminatedFemale Spermatheca    613.5 Adult Ovary    793.5 Adult Testis    816.2 Adult Male Accessory Gland    239 Adult Carcass    721.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    407.025 Larval Midgut    232.5 Larval Hindgut    243.6 Larval Malpighian Tubules    183.4 Larval Fat Body    271.2 Larval Salivary Gland    107.1 Larval Trachea    176.075 Larval Carcass    188.875 Adult Head    586 Adult Eye    390.025 Adult Brain    880 Adult Thoracic-Abdominal Ganglion    1067.9 Adult Crop    231.1 Adult Midgut    236.3 Adult Hindgut    204.2 Adult Malpighian Tubules    244.8 Adult Fat Body    1188.3 Adult Salivary Gland    152.3 Adult Heart    712.5 Adult VirginFemale Spermatheca    728.7 Adult InseminatedFemale Spermatheca    613.5 Adult Ovary    793.5 Adult Testis    816.2 Adult Male Accessory Gland    239 Adult Carcass    721.5 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    407.025 Larval Midgut    232.5 Larval Hindgut    243.6 Larval Malpighian Tubules    183.4 Larval Fat Body    271.2 Larval Salivary Gland    107.1 Larval Trachea    176.075 Larval Carcass    188.875 Adult Head    586 Adult Eye    390.025 Adult Brain    880 Adult Thoracic-Abdominal Ganglion    1067.9 Adult Crop    231.1 Adult Midgut    236.3 Adult Hindgut    204.2 Adult Malpighian Tubules    244.8 Adult Fat Body    1188.3 Adult Salivary Gland    152.3 Adult Heart    712.5 Adult VirginFemale Spermatheca    728.7 Adult InseminatedFemale Spermatheca    613.5 Adult Ovary    793.5 Adult Testis    816.2 Adult Male Accessory Gland    239 Adult Carcass    721.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    407.025 Larval Midgut    232.5 Larval Hindgut    243.6 Larval Malpighian Tubules    183.4 Larval Fat Body    271.2 Larval Salivary Gland    107.1 Larval Trachea    176.075 Larval Carcass    188.875 Adult Head  586 Adult Eye    390.025 Adult Brain  (880) Adult Thoracic-Abdominal Ganglion  (1067.9) Adult Crop    231.1 Adult Midgut    236.3 Adult Hindgut    204.2 Adult Malpighian Tubules    244.8 Adult Fat Body  (1188.3) Adult Salivary Gland    152.3 Adult Heart  712.5 Adult VirginFemale Spermatheca  728.7 Adult InseminatedFemale Spermatheca  613.5 Adult Ovary  793.5 Adult Testis  (816.2) Adult Male Accessory Gland    239 Adult Carcass  721.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    407.025 Larval Midgut    232.5 Larval Hindgut    243.6 Larval Malpighian Tubules    183.4 Larval Fat Body    271.2 Larval Salivary Gland    107.1 Larval Trachea    176.075 Larval Carcass    188.875 Adult Head    586 Adult Eye    390.025 Adult Brain    880 Adult Thoracic-Abdominal Ganglion  1067.9 Adult Crop    231.1 Adult Midgut    236.3 Adult Hindgut    204.2 Adult Malpighian Tubules    244.8 Adult Fat Body  1188.3 Adult Salivary Gland    152.3 Adult Heart    712.5 Adult VirginFemale Spermatheca    728.7 Adult InseminatedFemale Spermatheca    613.5 Adult Ovary    793.5 Adult Testis    816.2 Adult Male Accessory Gland    239 Adult Carcass    721.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    407.025 Larval Midgut    232.5 Larval Hindgut    243.6 Larval Malpighian Tubules    183.4 Larval Fat Body    271.2 Larval Salivary Gland    107.1 Larval Trachea    176.075 Larval Carcass    188.875 Adult Head    586 Adult Eye    390.025 Adult Brain    880 Adult Thoracic-Abdominal Ganglion    1067.9 Adult Crop    231.1 Adult Midgut    236.3 Adult Hindgut    204.2 Adult Malpighian Tubules    244.8 Adult Fat Body    1188.3 Adult Salivary Gland    152.3 Adult Heart    712.5 Adult VirginFemale Spermatheca    728.7 Adult InseminatedFemale Spermatheca    613.5 Adult Ovary    793.5 Adult Testis    816.2 Adult Male Accessory Gland    239 Adult Carcass    721.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    586   NA  Eye    390.025   NA  Brain    880   407.025  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    1067.9   NA  Crop    231.1   232.5  Midgut    236.3   243.6  Hindgut    204.2   183.4  Malpighian Tubules    244.8   271.2  Fat Body    1188.3   107.1  Salivary Gland    152.3   NA  Heart    712.5   176.075  Trachea    NA   NA  VirginFemale Spermatheca    728.7   NA  InseminatedFemale Spermatheca    613.5   NA  Ovary    793.5   NA  Testis    816.2   NA  Male Accessory Gland    239   188.875  Carcass    721.5 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    38 central nervous system, larvae L3    23 central nervous system, pupae P8    25 head, virgin 1-day female    39 head, virgin 4-day female    43 head, virgin 20-day female    31 head, mated 1-day female    45 head, mated 4-day female    44 head, mated 20-day female    31 head, mated 1-day male    51 head, mated 4-day male    51 head, mated 20-day male    47 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    14 digestive system, 4-day adult    22 digestive system, 20-day adult    19 fat body, larvae L3 wandering    16 fat body, white prepupae    22 fat body, pupae P8    19 carcass, larvae L3 wandering    14 carcass, 1-day adult    31 carcass, 4-day adult    35 carcass, 20-day adult    34 ovary, virgin 4-day female    71 ovary, mated 4-day female    92 testis, mated 4-day male    63 accessory gland, mated 4-day male    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (38) central nervous system, larvae L3    23 central nervous system, pupae P8    25 head, virgin 1-day female  (39) head, virgin 4-day female  (43) head, virgin 20-day female  (31) head, mated 1-day female  (45) head, mated 4-day female  (44) head, mated 20-day female  (31) head, mated 1-day male  (51) head, mated 4-day male  (51) head, mated 20-day male  (47) salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    14 digestive system, 4-day adult    22 digestive system, 20-day adult    19 fat body, larvae L3 wandering    16 fat body, white prepupae    22 fat body, pupae P8    19 carcass, larvae L3 wandering    14 carcass, 1-day adult  (31) carcass, 4-day adult  (35) carcass, 20-day adult  (34) ovary, virgin 4-day female  (71) ovary, mated 4-day female  (92) testis, mated 4-day male  (63) accessory gland, mated 4-day male    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    38 central nervous system, larvae L3    23 central nervous system, pupae P8    25 head, virgin 1-day female    39 head, virgin 4-day female    43 head, virgin 20-day female    31 head, mated 1-day female    45 head, mated 4-day female    44 head, mated 20-day female    31 head, mated 1-day male    51 head, mated 4-day male    51 head, mated 20-day male    47 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    14 digestive system, 4-day adult    22 digestive system, 20-day adult    19 fat body, larvae L3 wandering    16 fat body, white prepupae    22 fat body, pupae P8    19 carcass, larvae L3 wandering    14 carcass, 1-day adult    31 carcass, 4-day adult    35 carcass, 20-day adult    34 ovary, virgin 4-day female    71 ovary, mated 4-day female    92 testis, mated 4-day male    63 accessory gland, mated 4-day male    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    38 central nervous system, larvae L3    23 central nervous system, pupae P8    25 head, virgin 1-day female    39 head, virgin 4-day female    43 head, virgin 20-day female    31 head, mated 1-day female    45 head, mated 4-day female    44 head, mated 20-day female    31 head, mated 1-day male    51 head, mated 4-day male    51 head, mated 20-day male    47 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    14 digestive system, 4-day adult    22 digestive system, 20-day adult    19 fat body, larvae L3 wandering    16 fat body, white prepupae    22 fat body, pupae P8    19 carcass, larvae L3 wandering    14 carcass, 1-day adult    31 carcass, 4-day adult    35 carcass, 20-day adult    34 ovary, virgin 4-day female    71 ovary, mated 4-day female    92 testis, mated 4-day male    63 accessory gland, mated 4-day male    12 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    38 central nervous system, larvae L3    23 central nervous system, pupae P8    25 head, virgin 1-day female    39 head, virgin 4-day female    43 head, virgin 20-day female    31 head, mated 1-day female    45 head, mated 4-day female    44 head, mated 20-day female    31 head, mated 1-day male    51 head, mated 4-day male    51 head, mated 20-day male    47 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    14 digestive system, 4-day adult    22 digestive system, 20-day adult    19 fat body, larvae L3 wandering    16 fat body, white prepupae    22 fat body, pupae P8    19 carcass, larvae L3 wandering    14 carcass, 1-day adult    31 carcass, 4-day adult    35 carcass, 20-day adult    34 ovary, virgin 4-day female    71 ovary, mated 4-day female    92 testis, mated 4-day male    63 accessory gland, mated 4-day male    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (38) central nervous system, larvae L3    23 central nervous system, pupae P8    25 head, virgin 1-day female  (39) head, virgin 4-day female  (43) head, virgin 20-day female  31 head, mated 1-day female  (45) head, mated 4-day female  (44) head, mated 20-day female  31 head, mated 1-day male  (51) head, mated 4-day male  (51) head, mated 20-day male  (47) salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    14 digestive system, 4-day adult    22 digestive system, 20-day adult    19 fat body, larvae L3 wandering    16 fat body, white prepupae    22 fat body, pupae P8    19 carcass, larvae L3 wandering    14 carcass, 1-day adult  31 carcass, 4-day adult  (35) carcass, 20-day adult  (34) ovary, virgin 4-day female  (71) ovary, mated 4-day female  (92) testis, mated 4-day male  (63) accessory gland, mated 4-day male    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    38 central nervous system, larvae L3    23 central nervous system, pupae P8    25 head, virgin 1-day female    39 head, virgin 4-day female    43 head, virgin 20-day female    31 head, mated 1-day female    45 head, mated 4-day female    44 head, mated 20-day female    31 head, mated 1-day male    51 head, mated 4-day male    51 head, mated 20-day male    47 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    14 digestive system, 4-day adult    22 digestive system, 20-day adult    19 fat body, larvae L3 wandering    16 fat body, white prepupae    22 fat body, pupae P8    19 carcass, larvae L3 wandering    14 carcass, 1-day adult    31 carcass, 4-day adult    35 carcass, 20-day adult    34 ovary, virgin 4-day female    71 ovary, mated 4-day female    92 testis, mated 4-day male    63 accessory gland, mated 4-day male    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    38 central nervous system, larvae L3    23 central nervous system, pupae P8    25 head, virgin 1-day female    39 head, virgin 4-day female    43 head, virgin 20-day female    31 head, mated 1-day female    45 head, mated 4-day female    44 head, mated 20-day female    31 head, mated 1-day male    51 head, mated 4-day male    51 head, mated 20-day male    47 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    14 digestive system, 4-day adult    22 digestive system, 20-day adult    19 fat body, larvae L3 wandering    16 fat body, white prepupae    22 fat body, pupae P8    19 carcass, larvae L3 wandering    14 carcass, 1-day adult    31 carcass, 4-day adult    35 carcass, 20-day adult    34 ovary, virgin 4-day female    71 ovary, mated 4-day female    92 testis, mated 4-day male    63 accessory gland, mated 4-day male    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages, during late pupal stages, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    75 embryo 02-04hr    56 embryo 04-06hr    35 embryo 06-08hr    27 embryo 08-10hr    27 embryo 10-12hr    21 embryo 12-14hr    24 embryo 14-16hr    27 embryo 16-18hr    22 embryo 18-20hr    19 embryo 20-22hr    23 embryo 22-24hr    23 larva L1    16 larva L2    9 larva L3 12hr old    10 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    16 white prepupae new    22 white prepupae 12hr    27 white prepupae 24hr    29 pupae 2d postWPP    27 pupae 3d postWPP    22 pupae 4d postWPP    57 adult male 01day    49 adult male 05day    55 adult male 30day    55 adult female 01day    47 adult female 05day    51 adult female 30day    54 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (75) embryo 02-04hr  (56) embryo 04-06hr  (35) embryo 06-08hr  (27) embryo 08-10hr  (27) embryo 10-12hr    21 embryo 12-14hr    24 embryo 14-16hr  (27) embryo 16-18hr    22 embryo 18-20hr    19 embryo 20-22hr    23 embryo 22-24hr    23 larva L1    16 larva L2    9 larva L3 12hr old    10 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    16 white prepupae new    22 white prepupae 12hr  (27) white prepupae 24hr  (29) pupae 2d postWPP  (27) pupae 3d postWPP    22 pupae 4d postWPP  (57) adult male 01day  (49) adult male 05day  (55) adult male 30day  (55) adult female 01day  (47) adult female 05day  (51) adult female 30day  (54) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    75 embryo 02-04hr    56 embryo 04-06hr    35 embryo 06-08hr    27 embryo 08-10hr    27 embryo 10-12hr    21 embryo 12-14hr    24 embryo 14-16hr    27 embryo 16-18hr    22 embryo 18-20hr    19 embryo 20-22hr    23 embryo 22-24hr    23 larva L1    16 larva L2    9 larva L3 12hr old    10 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    16 white prepupae new    22 white prepupae 12hr    27 white prepupae 24hr    29 pupae 2d postWPP    27 pupae 3d postWPP    22 pupae 4d postWPP    57 adult male 01day    49 adult male 05day    55 adult male 30day    55 adult female 01day    47 adult female 05day    51 adult female 30day    54 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    75 embryo 02-04hr    56 embryo 04-06hr    35 embryo 06-08hr    27 embryo 08-10hr    27 embryo 10-12hr    21 embryo 12-14hr    24 embryo 14-16hr    27 embryo 16-18hr    22 embryo 18-20hr    19 embryo 20-22hr    23 embryo 22-24hr    23 larva L1    16 larva L2    9 larva L3 12hr old    10 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    16 white prepupae new    22 white prepupae 12hr    27 white prepupae 24hr    29 pupae 2d postWPP    27 pupae 3d postWPP    22 pupae 4d postWPP    57 adult male 01day    49 adult male 05day    55 adult male 30day    55 adult female 01day    47 adult female 05day    51 adult female 30day    54 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    75 embryo 02-04hr    56 embryo 04-06hr    35 embryo 06-08hr    27 embryo 08-10hr    27 embryo 10-12hr    21 embryo 12-14hr    24 embryo 14-16hr    27 embryo 16-18hr    22 embryo 18-20hr    19 embryo 20-22hr    23 embryo 22-24hr    23 larva L1    16 larva L2    9 larva L3 12hr old    10 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    16 white prepupae new    22 white prepupae 12hr    27 white prepupae 24hr    29 pupae 2d postWPP    27 pupae 3d postWPP    22 pupae 4d postWPP    57 adult male 01day    49 adult male 05day    55 adult male 30day    55 adult female 01day    47 adult female 05day    51 adult female 30day    54 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (75) embryo 02-04hr  (56) embryo 04-06hr  (35) embryo 06-08hr  27 embryo 08-10hr  27 embryo 10-12hr    21 embryo 12-14hr    24 embryo 14-16hr  27 embryo 16-18hr    22 embryo 18-20hr    19 embryo 20-22hr    23 embryo 22-24hr    23 larva L1    16 larva L2    9 larva L3 12hr old    10 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    16 white prepupae new    22 white prepupae 12hr  27 white prepupae 24hr  29 pupae 2d postWPP  27 pupae 3d postWPP    22 pupae 4d postWPP  (57) adult male 01day  (49) adult male 05day  (55) adult male 30day  (55) adult female 01day  (47) adult female 05day  (51) adult female 30day  (54) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    75 embryo 02-04hr    56 embryo 04-06hr    35 embryo 06-08hr    27 embryo 08-10hr    27 embryo 10-12hr    21 embryo 12-14hr    24 embryo 14-16hr    27 embryo 16-18hr    22 embryo 18-20hr    19 embryo 20-22hr    23 embryo 22-24hr    23 larva L1    16 larva L2    9 larva L3 12hr old    10 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    16 white prepupae new    22 white prepupae 12hr    27 white prepupae 24hr    29 pupae 2d postWPP    27 pupae 3d postWPP    22 pupae 4d postWPP    57 adult male 01day    49 adult male 05day    55 adult male 30day    55 adult female 01day    47 adult female 05day    51 adult female 30day    54 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    75 embryo 02-04hr    56 embryo 04-06hr    35 embryo 06-08hr    27 embryo 08-10hr    27 embryo 10-12hr    21 embryo 12-14hr    24 embryo 14-16hr    27 embryo 16-18hr    22 embryo 18-20hr    19 embryo 20-22hr    23 embryo 22-24hr    23 larva L1    16 larva L2    9 larva L3 12hr old    10 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    16 white prepupae new    22 white prepupae 12hr    27 white prepupae 24hr    29 pupae 2d postWPP    27 pupae 3d postWPP    22 pupae 4d postWPP    57 adult male 01day    49 adult male 05day    55 adult male 30day    55 adult female 01day    47 adult female 05day    51 adult female 30day    54 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    27 Schneider line 2 Sg4    9 embryonic 1182-4H    27 embryonic GM2    74 embryonic Kc167    11 embryonic S1    14 embryonic S3    12 leg disc CME L1    11 wing disc CME-W2    12 wing disc ML-DmD8    13 wing disc ML-DmD9    21 wing disc ML-DmD16-c3    20 wing disc ML-DmD21    10 wing disc ML-DmD32    14 haltere disc ML-DmD17-c3    22 eye-antennal disc ML-DmD11    21 antennal disc ML-DmD20-c5    7 mixed discs ML-DmD4-c1    19 CNS ML-DmBG1-c1    22 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2    16 ovary fGS/OSS    37 ovary OSC    32 ovary OSS    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (27) Schneider line 2 Sg4    9 embryonic 1182-4H  (27) embryonic GM2  (74) embryonic Kc167    11 embryonic S1    14 embryonic S3    12 leg disc CME L1    11 wing disc CME-W2    12 wing disc ML-DmD8    13 wing disc ML-DmD9    21 wing disc ML-DmD16-c3    20 wing disc ML-DmD21    10 wing disc ML-DmD32    14 haltere disc ML-DmD17-c3    22 eye-antennal disc ML-DmD11    21 antennal disc ML-DmD20-c5    7 mixed discs ML-DmD4-c1    19 CNS ML-DmBG1-c1    22 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2    16 ovary fGS/OSS  (37) ovary OSC  (32) ovary OSS    23 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    27 Schneider line 2 Sg4    9 embryonic 1182-4H    27 embryonic GM2    74 embryonic Kc167    11 embryonic S1    14 embryonic S3    12 leg disc CME L1    11 wing disc CME-W2    12 wing disc ML-DmD8    13 wing disc ML-DmD9    21 wing disc ML-DmD16-c3    20 wing disc ML-DmD21    10 wing disc ML-DmD32    14 haltere disc ML-DmD17-c3    22 eye-antennal disc ML-DmD11    21 antennal disc ML-DmD20-c5    7 mixed discs ML-DmD4-c1    19 CNS ML-DmBG1-c1    22 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2    16 ovary fGS/OSS    37 ovary OSC    32 ovary OSS    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    27 Schneider line 2 Sg4    9 embryonic 1182-4H    27 embryonic GM2    74 embryonic Kc167    11 embryonic S1    14 embryonic S3    12 leg disc CME L1    11 wing disc CME-W2    12 wing disc ML-DmD8    13 wing disc ML-DmD9    21 wing disc ML-DmD16-c3    20 wing disc ML-DmD21    10 wing disc ML-DmD32    14 haltere disc ML-DmD17-c3    22 eye-antennal disc ML-DmD11    21 antennal disc ML-DmD20-c5    7 mixed discs ML-DmD4-c1    19 CNS ML-DmBG1-c1    22 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2    16 ovary fGS/OSS    37 ovary OSC    32 ovary OSS    23 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    27 Schneider line 2 Sg4    9 embryonic 1182-4H    27 embryonic GM2    74 embryonic Kc167    11 embryonic S1    14 embryonic S3    12 leg disc CME L1    11 wing disc CME-W2    12 wing disc ML-DmD8    13 wing disc ML-DmD9    21 wing disc ML-DmD16-c3    20 wing disc ML-DmD21    10 wing disc ML-DmD32    14 haltere disc ML-DmD17-c3    22 eye-antennal disc ML-DmD11    21 antennal disc ML-DmD20-c5    7 mixed discs ML-DmD4-c1    19 CNS ML-DmBG1-c1    22 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2    16 ovary fGS/OSS    37 ovary OSC    32 ovary OSS    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  27 Schneider line 2 Sg4    9 embryonic 1182-4H  27 embryonic GM2  (74) embryonic Kc167    11 embryonic S1    14 embryonic S3    12 leg disc CME L1    11 wing disc CME-W2    12 wing disc ML-DmD8    13 wing disc ML-DmD9    21 wing disc ML-DmD16-c3    20 wing disc ML-DmD21    10 wing disc ML-DmD32    14 haltere disc ML-DmD17-c3    22 eye-antennal disc ML-DmD11    21 antennal disc ML-DmD20-c5    7 mixed discs ML-DmD4-c1    19 CNS ML-DmBG1-c1    22 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2    16 ovary fGS/OSS  (37) ovary OSC  32 ovary OSS    23 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    27 Schneider line 2 Sg4    9 embryonic 1182-4H    27 embryonic GM2    74 embryonic Kc167    11 embryonic S1    14 embryonic S3    12 leg disc CME L1    11 wing disc CME-W2    12 wing disc ML-DmD8    13 wing disc ML-DmD9    21 wing disc ML-DmD16-c3    20 wing disc ML-DmD21    10 wing disc ML-DmD32    14 haltere disc ML-DmD17-c3    22 eye-antennal disc ML-DmD11    21 antennal disc ML-DmD20-c5    7 mixed discs ML-DmD4-c1    19 CNS ML-DmBG1-c1    22 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2    16 ovary fGS/OSS    37 ovary OSC    32 ovary OSS    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    27 Schneider line 2 Sg4    9 embryonic 1182-4H    27 embryonic GM2    74 embryonic Kc167    11 embryonic S1    14 embryonic S3    12 leg disc CME L1    11 wing disc CME-W2    12 wing disc ML-DmD8    13 wing disc ML-DmD9    21 wing disc ML-DmD16-c3    20 wing disc ML-DmD21    10 wing disc ML-DmD32    14 haltere disc ML-DmD17-c3    22 eye-antennal disc ML-DmD11    21 antennal disc ML-DmD20-c5    7 mixed discs ML-DmD4-c1    19 CNS ML-DmBG1-c1    22 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2    16 ovary fGS/OSS    37 ovary OSC    32 ovary OSS    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    37 cold shock, 4-day adult    28 heat shock, 4-day adult    26 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    29 Cadmium 100 mM 48 hrs, 4-day adult    75 Copper 0.5 mM 12 hrs, larvae L3    10 Copper 15 mM 48 hrs, 4-day adult    70 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    58 Ethanol 2.5% 3 hrs, larvae L3    68 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    60 Caffeine 25 mg/ml 48 hrs, 4-day adult    36 Paraquat 5 mM 48 hrs, 4-day adult    58 Paraquat 10 mM 48 hrs, 4-day adult    61 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (37) cold shock, 4-day adult  (28) heat shock, 4-day adult  26 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult  (29) Cadmium 100 mM 48 hrs, 4-day adult  (75) Copper 0.5 mM 12 hrs, larvae L3    10 Copper 15 mM 48 hrs, 4-day adult  (70) Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult  (58) Ethanol 2.5% 3 hrs, larvae L3  (68) Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (60) Caffeine 25 mg/ml 48 hrs, 4-day adult  (36) Paraquat 5 mM 48 hrs, 4-day adult  (58) Paraquat 10 mM 48 hrs, 4-day adult  (61) Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    37 cold shock, 4-day adult    28 heat shock, 4-day adult    26 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    29 Cadmium 100 mM 48 hrs, 4-day adult    75 Copper 0.5 mM 12 hrs, larvae L3    10 Copper 15 mM 48 hrs, 4-day adult    70 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    58 Ethanol 2.5% 3 hrs, larvae L3    68 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    60 Caffeine 25 mg/ml 48 hrs, 4-day adult    36 Paraquat 5 mM 48 hrs, 4-day adult    58 Paraquat 10 mM 48 hrs, 4-day adult    61 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    37 cold shock, 4-day adult    28 heat shock, 4-day adult    26 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    29 Cadmium 100 mM 48 hrs, 4-day adult    75 Copper 0.5 mM 12 hrs, larvae L3    10 Copper 15 mM 48 hrs, 4-day adult    70 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    58 Ethanol 2.5% 3 hrs, larvae L3    68 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    60 Caffeine 25 mg/ml 48 hrs, 4-day adult    36 Paraquat 5 mM 48 hrs, 4-day adult    58 Paraquat 10 mM 48 hrs, 4-day adult    61 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    37 cold shock, 4-day adult    28 heat shock, 4-day adult    26 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    29 Cadmium 100 mM 48 hrs, 4-day adult    75 Copper 0.5 mM 12 hrs, larvae L3    10 Copper 15 mM 48 hrs, 4-day adult    70 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    58 Ethanol 2.5% 3 hrs, larvae L3    68 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    60 Caffeine 25 mg/ml 48 hrs, 4-day adult    36 Paraquat 5 mM 48 hrs, 4-day adult    58 Paraquat 10 mM 48 hrs, 4-day adult    61 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (37) cold shock, 4-day adult  28 heat shock, 4-day adult  26 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult  29 Cadmium 100 mM 48 hrs, 4-day adult  (75) Copper 0.5 mM 12 hrs, larvae L3    10 Copper 15 mM 48 hrs, 4-day adult  (70) Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult  (58) Ethanol 2.5% 3 hrs, larvae L3  (68) Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (60) Caffeine 25 mg/ml 48 hrs, 4-day adult  (36) Paraquat 5 mM 48 hrs, 4-day adult  (58) Paraquat 10 mM 48 hrs, 4-day adult  (61) Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    37 cold shock, 4-day adult    28 heat shock, 4-day adult    26 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    29 Cadmium 100 mM 48 hrs, 4-day adult    75 Copper 0.5 mM 12 hrs, larvae L3    10 Copper 15 mM 48 hrs, 4-day adult    70 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    58 Ethanol 2.5% 3 hrs, larvae L3    68 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    60 Caffeine 25 mg/ml 48 hrs, 4-day adult    36 Paraquat 5 mM 48 hrs, 4-day adult    58 Paraquat 10 mM 48 hrs, 4-day adult    61 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    37 cold shock, 4-day adult    28 heat shock, 4-day adult    26 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    29 Cadmium 100 mM 48 hrs, 4-day adult    75 Copper 0.5 mM 12 hrs, larvae L3    10 Copper 15 mM 48 hrs, 4-day adult    70 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    58 Ethanol 2.5% 3 hrs, larvae L3    68 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    60 Caffeine 25 mg/ml 48 hrs, 4-day adult    36 Paraquat 5 mM 48 hrs, 4-day adult    58 Paraquat 10 mM 48 hrs, 4-day adult    61 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_26 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003656 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2212-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable swsCC01711 viable, with Scer\GAL4pnr-MD237 swsGD3277 Other Phenotypes Allele neuroanatomy defective sws1 neuroanatomy defective, with Scer\GAL4GMR.PF swsScer\UAS.cMa neuroanatomy defective, with Scer\GAL4loco.1.3 swsScer\UAS.cMa neuroanatomy defective | adult stage sws1 short lived sws4 sws5 sws6 smell perception defective swsolfE-x26 smell perception defective | recessive swsolfE-x26 Phenotype manifest in Allele adult brain sws1 CNS glial cell sws1 CNS glial cell, with Scer\GAL4loco.1.3 swsScer\UAS.cMa cortex of lamina sws1 epithelial glial cell, with Scer\GAL4loco.1.3 swsScer\UAS.cMa eye photoreceptor cell, with Scer\GAL4GMR.PF swsScer\UAS.cMa neuropil sws1
Classical Alleles ( 15 )
For All Classical Alleles Show
Allele of sws Class Mutagen Stocks Known lesion swsolfE-x26 amorphic allele - genetic evidence ethyl methanesulfonate 1 -- sws4 1 Yes swsd07605 P-element activity 1 -- swsf06375 piggyBac transposase 1 -- swsG17521 P-element activity 1 -- swsG17614 P-element activity 1 -- swsG983 P-element activity 1 -- swsNP4072 1 -- sws1 ethyl methanesulfonate 0 Yes sws2 ethyl methanesulfonate 0 -- sws3 ethyl methanesulfonate 0 -- sws5 0 Yes sws6 0 -- swsCC01711 P-element activity 0 Yes swsunspecified 0 --
Alleles Carried on Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Allele of sws Class Mutagen Stocks Known lesion swsGD3277 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes swsGLC01426 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes swsJF03428 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes swsNIG.2212R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes swsolfE-E2 in vitro construct - genomic fragment 0 Yes swsS985D.Scer\UAS in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes swsScer\UAS.cMa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(1)C128 (Hasan, 1989, Ayyub et al., 1990, Hasan, 1990, Monastirioti et al., 1996, Kretzschmar et al., 1997) Df(1)sn-13a1 (Hasan, 1989, Hasan, 1990) Df(1)sn+72d (Hasan, 1989, Hasan, 1990)
Duplicated in	Dp(1;2)sn+72d (Ayyub et al., 1990, Monastirioti et al., 1996) Dp(1;3)sn13a1 (Hasan, 1990, Kretzschmar et al., 1997) Tp(1;3)sn13a1 (Hasan, 1990)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD3277} NA P{NIG.2212R} NA P{TRiP.GLC01426} NA P{TRiP.JF03428} NA P{UAS-sws.M} NA P{UAS-sws.S985D} NA characterization construct P{Car20-E2} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap binary system P{GawB}swsNP4072 No miscellaneous insertions P{PTT-GC}swsCC01711 NA PBac{WH}swsf06375 NA insertion of mobile activating element P{EP}snG983 NA P{EP}swsG17521 NA P{EP}swsG17614 NA P{XP}swsd07605 NA
Gene Ontology: Function, Process & Cellular Component ( 9 unique terms )
Terms Based on Experimental Evidence ( 8 terms )
Molecular Function
CV term Evidence References
lysophospholipase activity inferred from direct assay (assigned by UniProtKB) (Bettencourt da Cruz et al., 2008) protein binding inferred from physical interaction with UniProtKB:P16912 (assigned by UniProtKB) (Bettencourt da Cruz et al., 2008)
Biological Process
CV term Evidence References
cellular membrane organization inferred from direct assay (Muhlig-Versen et al., 2005) membrane lipid metabolic process inferred from direct assay (Muhlig-Versen et al., 2005) neuron apoptotic process inferred from mutant phenotype (Muhlig-Versen et al., 2005) phosphatidylcholine metabolic process inferred from direct assay (Muhlig-Versen et al., 2005) sensory perception of smell inferred from mutant phenotype (Ayyub and Paranjape, 2002)
Cellular Component
CV term Evidence References
endoplasmic reticulum membrane inferred from direct assay (assigned by UniProtKB) (Bettencourt da Cruz et al., 2008)
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
brain development non-traceable author statement (Swiss-Prot Project Members, 2000.10.1)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
sws - CG10934 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sws - CG5196 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions sws allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0003656 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31716
Orthologs
OrthoDB Orthologs (46) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6575RW Dipteran inclusive ortholog search EOG61ZFJT Insect inclusive ortholog search EOG6RFJNC Arthropod inclusive ortholog search EOG6FXPPB Metazoa inclusive ortholog search EOG6W71NP
Orthologs in Drosophila Species (EOG6575RW)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\sws     Drosophila simulans   Dsim\sws Y   Drosophila sechellia   Dsec\GM11957 Y   Drosophila erecta   Dere\GG17592 Y   Drosophila yakuba   Dyak\GE17492 Y   Drosophila ananassae   Dana\GF20991 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA22927 Y   Drosophila persimilis   Dper\GL15243 Y   Drosophila willistoni   Dwil\GK16217 Y   Drosophila virilis   Dvir\GJ16892 Y   Drosophila mojavensis   Dmoj\GI21654 Y   Drosophila grimshawi   Dgri\GH24540 Y
Orthologs in non-Drosophila Dipterans (EOG61ZFJT)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL013811   Anopheles gambiae Malaria mosquito  Agam\AGAP000467   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ003198
Orthologs in non-Dipteran Insects (EOG6RFJNC)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB49111   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG002714   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH16487   Atta cephalotes Leafcutter ant  Acep\ACEP25338   Camponotus floridanus Florida carpenter ant  Cflo\CFLO12546   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL20808   Linepithema humile Argentine ant  Lhum\LH18970   Pogonomyrmex barbatus Red harvester ant  Pbar\PB13690   Solenopsis invicta Red fire ant  Sinv\SINV10444   Acyrthosiphon pisum Pea aphid  Apim\ACYPI009511   Bombyx mori Silkmoth  Bmor\BGIBMGA007928   Bombyx mori Silkmoth  Bmor\BGIBMGA007927   Pediculus humanus Human body louse  Phum\PHUM488870   Tribolium castaneum Red flour beetle  Tcas\TC001035
Orthologs in non-Insect Arthropods (EOG6FXPPB)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\cops4
Orthologs in non-Arthropod Metazoa (EOG6W71NP)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\ZK370.4   Caenorhabditis elegans Nematode  Cele\M110.7   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_011154gn   Danio rerio Zebrafish  Drer\pnpla7a   Danio rerio Zebrafish  Drer\pnpla6   Danio rerio Zebrafish  Drer\pnpla7b   Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000031537   Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000032579   Gallus gallus Domestic chicken  Ggal\ENSGALG00000007881   Gallus gallus Domestic chicken  Ggal\PNPLA7   Mus musculus House mouse  Mmus\Pnpla7   Mus musculus House mouse  Mmus\ENSMUSG00000004565   Rattus norvegicus Norway rat  Rnor\Pnpla6   Rattus norvegicus Norway rat  Rnor\Pnpla7   Homo sapiens Human  Hsap\ENSG00000130653   Homo sapiens Human  Hsap\ENSG00000032444
Human Orthologs (2)
Gene OMIM HGNC Hsap\ENSG00000130653     Hsap\ENSG00000032444
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\sws Drosophila sechellia Dsec\GM11957 Drosophila erecta Dere\GG17592 Drosophila yakuba Dyak\GE17492 Drosophila ananassae Dana\GF20991 Drosophila pseudoobscura pseudoobscura Dpse\GA22927 Drosophila persimilis Dper\GL15243 Drosophila willistoni Dwil\GK16217 Drosophila virilis Dvir\GJ16892 Drosophila mojavensis Dmoj\GI21654 Drosophila grimshawi Dgri\GH24540
Stocks & Reagents
Stocks Listed in FlyBase ( 11 )
Bloomington	1015 swsolfE-x26 33321 w* P{EP}swsG17521 33325 w* P{EP}swsG17614 31993 y1 v1; P{TRiP.JF03428}attP2 33552 w* P{EP}snG983 swsG983 28121 sws4/C(1)DX, y1 w1 f1 43239 y1 sc* v1; P{TRiP.GLC01426}attP2
Harvard	- P{XP}swsd07605 - PBac{WH}swsf06375
Kyoto	104592 y* w* P{GawB}swsNP4072 / FM7c
VDRC	v5469 w1118; P{GD3277}v5469
Genomic Clones ( 1 )
	BACR24A02 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 56 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH25996 GM04921 LD36116
Other clones	FI19439
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT13501 AT21047 GH08579 LD37778 LD41208 LP14940 LP16496 SD10078 SD13934 SD15112 SD26496
Other clones	39273 44453 47564 47592 58994 66137 71880 74122 79207 107181 107694 107813 146844 162249 179651 214225.14 277559 bs11c01 Dmel_dig_006479_0639_2315 EC34938 EC054581 EK156235 EK159660 EK171440 EK175850 EK182533 EK193944 EK200249 EK205309 EK233538 EK234028 EK249618 EK265725 EP02415 EP11642 IP01987 IP04362 IP15269 IP15369 IP15469 IP15569
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0003656 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31716
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: sws CG2212 (Zhang, 1999.11)
Source for database merge of
Additional comments	complements olfA, olfB and olfF.
Other Comments
	sws is essential for membrane lipid homeostasis and cell survival in both neurons and glia. (Muhlig-Versen et al., 2005) sws mutants are characterised by progressive degeneration of the adult nervous system, glial hyperwrapping, and neuronal apoptosis. (Muhlig-Versen et al., 2005)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078520 NM_167140 NM_167141 RefSeq (Proteins) • NP_511075 NP_727224 NP_727225 DDBJ / EMBL / GenBank • AAF46305 AAL28979 AAN09222 AAN09223 AI456235 AI518304 AI945301 AJ571482 AJ571483 AJ571484 AJ571485 AJ571486 AJ571487 AJ571488 AJ571489 AJ571490 AJ571491 AJ571492 AJ571493 AJ571494 AJ571495 AJ571496 AJ571497 AJ571498 AJ571499 AJ571500 AJ571501 AJ571502 AJ571503 AJ571504 AJ571505 AW943322 AY061431 CAB51772 CZ475831 CZ475832 CZ489073 CZ489074 Z97187 Entrez Gene - A searchable database of RefSeq genes. • 31716 UniProtKB/Swiss-Prot • Q9U969 UniProtKB/TrEMBL • E1JJF4
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Cyclic nucleotide-binding-like (IPR018490) Cyclic nucleotide-binding domain (IPR000595) Lysophospholipase patatin, conserved site (IPR001423) Patatin/Phospholipase A2-related (IPR002641) RmlC-like jelly roll fold (IPR014710) Acyl transferase/acyl hydrolase/lysophospholipase (IPR016035)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0003656 DRSC - Results from RNAi screens. • FBgn0003656 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003656 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2212-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0003656 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31716 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31716 modMine - Data generated by the modENCODE project. • FBgn0003656
Synonyms & Secondary IDs ( 12 )
Reported As
Symbol Synonym	CG2212 (Perkins et al., 2009, Ni et al., 2010.12.1) olfE (Smith, 1996, Monastirioti et al., 1996, Carlson, 1996, Griff and Reed, 1995, Cant et al., 1994, Paterson and O'Hare, 1991, Vijay Raghavan et al., 1991, Ayyub et al., 1990, Ayyub and Paranjape, 2002, Lindsley and Zimm, 1992) sws (Wentzell et al., 2007, Ayyub and Paranjape, 2002, Buszczak et al., 2007, Muhlig-Versen et al., 2005, Lindsley and Zimm, 1992, Kuronen et al., 2009, Bettencourt da Cruz et al., 2008, Wentzell et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Krishnan et al., 2012) Sws (Zhang et al., 2002)
Name Synonym	olfactory E   olfactory-E (Lindsley and Zimm, 1992) swiss cheese (Kretzschmar, 1997.6.24, Wentzell et al., 2007, Lindsley and Zimm, 1992, Carbone et al., 2009, Krishnan et al., 2012) swisscheese (Ayyub and Paranjape, 2002) Swiss cheese (Muhlig-Versen et al., 2005) Swiss Cheese (Bettencourt da Cruz et al., 2008) swiss-cheese (Wentzell et al., 2012) Swisscheese (Pospisilik et al., 2010)
Secondary FlyBase IDs
	FBgn0004059
References ( 56 )
Generate a list of	All references relating to this gene ( 56 )
List References by type	Research paper  ( 20 ) Supplementary material  ( 3 ) Review  ( 9 ) Personal communication to FlyBase  ( 11 ) Abstract  ( 4 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 1 ) Book  ( 1 ) Stock list  ( 1 ) Curated genome annotation  ( 1 ) Protein sequence record  ( 1 ) Letter  ( 1 )
Recent research papers ( 2 )
	Krishnan et al., 2012, Neurobiol. Disease 45(3): 1129--1135 Loss of circadian clock accelerates aging in neurodegeneration-prone mutants. [FBrf0217432] Wentzell et al., 2012, Neurobiol. Disease 46(1): 78--87 Amyloid precursor proteins are protective in Drosophila models of progressive neurodegeneration. [FBrf0217742] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...