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General Information
Symbol
Dmel\Tbp
Species
D. melanogaster
Name
TATA binding protein
Annotation Symbol
CG9874
Feature Type
FlyBase ID
FBgn0003687
Gene Model Status
Stock Availability
Gene Snapshot
TATA binding protein (Tbp) encodes a basal transcription factor required at most RNA Pol I and Pol II-transcribed genes. Traditionally thought to be recruited only to TATA box containing promoters, recent work shows that promoters with very weak TATA box consensus sequences also recruit the product of Tbp as a part of the multisubunit TFIID basal transcription factor or via the SAGA histone acetyltransferase complex. [Date last reviewed: 2019-03-14]
Also Known As
TFIID, dTBP, TFIIDτ, TATA box-binding protein, dTFIID
Key Links
Genomic Location
Cytogenetic map
Sequence location
2R:21,686,192..21,687,642 [-]
Recombination map
2-96
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Protein Family (UniProt)
Belongs to the TBP family. (P20227)
Summaries
Gene Group (FlyBase)
TATA-BINDING PROTEIN AND TBP-RELATED FACTORS -
The TATA-binding protein-related factors (TRFs) and TATA-binding protein (TBP) are similar in sequence sharing a 180 amino acid saddle-shaped DNA binding core domain. TBP is required by all three RNA polymerases and was considered a universal transcription factor. Subsequently, metazoan TRFs were shown to mediate transcription independently of TBP and to regulate the expression of specific sets of genes. (Adapted from FBrf0162294, FBrf0131150 and FBrf0229757).
TRANSCRIPTION FACTOR II D -
The general transcription factor complex Transcription factor II D (TFIID) plays an important role in recruiting the transcription machinery to core promoters. TFIID is a complex composed of TBP and several TBP-associated factors. (Adapted from FBrf0125116 and FBrf0156065).
Protein Function (UniProtKB)
General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II.
(UniProt, P20227)
Summary (Interactive Fly)
general transcription factor - component of TFIID - activates TATA-dependent transcription and represses DPE-dependent transcription
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\Tbp or the JBrowse view of Dmel\Tbp for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.51
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0071679
1387
353
Additional Transcript Data and Comments
Reported size (kB)
1.6 (northern blot)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0071596
38.5
353
9.79
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
353 (aa); 38 (kD predicted)
Comments
External Data
Subunit Structure (UniProtKB)
Belongs to the TFIID complex which is composed of TATA binding protein (Tbp) and a number of TBP-associated factors (Tafs). Binds DNA as monomer. Interacts with TFIIA-L heterotrimer. Interacts with Taf1, Taf2, Taf5 and Taf12.
(UniProt, P20227)
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Tbp using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (31 terms)
Molecular Function (13 terms)
Terms Based on Experimental Evidence (9 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (6 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000013136
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000013136
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000013136
(assigned by GO_Central )
inferred from sequence or structural similarity with UniProtKB:P20226
(assigned by UniProt )
inferred from biological aspect of ancestor with PANTHER:PTN000013138
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000013136
(assigned by GO_Central )
Biological Process (13 terms)
Terms Based on Experimental Evidence (12 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000013138
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000013136
(assigned by GO_Central )
Cellular Component (5 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
inferred from direct assay
inferred from physical interaction with FLYBASE:Taf4; FB:FBgn0010280
inferred from physical interaction with FLYBASE:Taf6; FB:FBgn0010417
inferred from direct assay
inferred from physical interaction with FLYBASE:Taf105; FB:FBgn0022356
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000013136
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000013137
(assigned by GO_Central )
inferred from sequence or structural similarity with HGNC:11588
inferred from sequence or structural similarity with SGD:S000000950
inferred from biological aspect of ancestor with PANTHER:PTN000013138
(assigned by GO_Central )
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
organism

Comment: maternally deposited

northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Tbp transcripts are detected at a constant level throughout embryogenesis.
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Tbp protein is detected in the nuclei of somatic cells of ovaries including apical terminal filament cells, inner sheath cells, and follicular cells of the developing cysts. It is also detected in nurse cells but not in the oocyte. Tbp protein is detected in the spermatogonium, decreases rapidly in primary spermatocytes and is not detected in mature primary spermatocyte or in later stages of spermatogenesis.
Marker for
 
Subcellular Localization
CV Term
Evidence
References
inferred from direct assay
inferred from physical interaction with FLYBASE:Taf4; FB:FBgn0010280
inferred from physical interaction with FLYBASE:Taf6; FB:FBgn0010417
inferred from direct assay
inferred from physical interaction with FLYBASE:Taf105; FB:FBgn0022356
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Tbp in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 8 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 13 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Tbp
Transgenic constructs containing regulatory region of Tbp
Deletions and Duplications ( 0 )
Phenotypes
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
12 of 15
Yes
Yes
 
11 of 15
No
Yes
1 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
10 of 15
Yes
Yes
9 of 15
No
Yes
1 of 15
No
No
Rattus norvegicus (Norway rat) (3)
11 of 13
Yes
Yes
9 of 13
No
Yes
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (3)
10 of 12
Yes
Yes
10 of 12
Yes
Yes
1 of 12
No
No
Danio rerio (Zebrafish) (3)
12 of 15
Yes
Yes
7 of 15
No
Yes
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (2)
10 of 15
Yes
Yes
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (2)
7 of 9
Yes
Yes
7 of 9
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (1)
12 of 15
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (1)
9 of 12
Yes
Yes
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG09190D9S )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091508P3 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W09GJ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Apis mellifera
Western honey bee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Dendroctonus ponderosae
Mountain pine beetle
Dendroctonus ponderosae
Mountain pine beetle
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Cimex lectularius
Bed bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X09CR )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Strigamia maritima
European centipede
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0ENY )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Ciona intestinalis
Vase tunicate
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (4)
6 of 10
3 of 10
1 of 10
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Allele
Disease
Evidence
References
Potential Models Based on Orthology ( 2 )
Modifiers Based on Experimental Evidence ( 2 )
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Interactions
Summary of Physical Interactions
esyN Network Diagram
Show neighbor-neighbor interactions:
Select Layout:
Legend:
Protein
RNA
Selected Interactor(s)
Interactions Browser

Please see the Physical Interaction reports below for full details
protein-protein
Physical Interaction
Assay
References
Summary of Genetic Interactions
esyN Network Diagram
esyN Network Key:
Suppression
Enhancement

Please look at the allele data for full details of the genetic interactions
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
External Data
Subunit Structure (UniProtKB)
Belongs to the TFIID complex which is composed of TATA binding protein (Tbp) and a number of TBP-associated factors (Tafs). Binds DNA as monomer. Interacts with TFIIA-L heterotrimer. Interacts with Taf1, Taf2, Taf5 and Taf12.
(UniProt, P20227 )
Linkouts
BioGRID - A database of protein and genetic interactions.
DroID - A comprehensive database of gene and protein interactions.
InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
MIST (protein-protein) - An integrated Molecular Interaction Database
Pathways
Genomic Location and Detailed Mapping Data
Chromosome (arm)
2R
Recombination map
2-96
Cytogenetic map
Sequence location
2R:21,686,192..21,687,642 [-]
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
57F8-57F8
Limits computationally determined from genome sequence between P{EP}CG10082EP436&P{EP}EP712EP712 and P{EP}Tim10EP541&P{lacW}l(2)k09617k09617
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
57F8-57F10
(determined by in situ hybridisation)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Stocks and Reagents
Stocks (12)
Genomic Clones (15)
 

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (25)
 

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequences
BDGP DGC clones
Other clones
Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)
RNAi and Array Information
Linkouts
DRSC - Results frm RNAi screens
GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
Antibody Information
Laboratory Generated Antibodies
 
Commercially Available Antibodies
 
Other Information
Relationship to Other Genes
Source for database identify of
Source for database merge of
Additional comments
Other Comments
DNA-protein interactions: genome-wide binding profile assayed for Tbp protein in Kc167 cells; see Chromatin_types_NKI collection report. Individual protein-binding experiments listed under "Samples" at GEO_GSE22069 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE22069).
dsRNA has been made from templates generated with primers directed against this gene.
The proteins encoded by Tbp, Taf1, Taf2 and Taf11 are likely peripheral subunits of TFIID.
The mechanism of transcriptional repression by eve protein involves a direct interaction with the Tbp protein.
Hsf interacts directly with the general transcription factor Tbp and these two factor bind cooperatively to heat shock promoters. Interaction of Hsf and Tbp is mediated by residues in both the amino and carboxy terminus of Hsf. The acidic domain of RpII215 associates with Tbp in vitro and is specifically displaced from Tbp upon addition of Hsf. Trl also interacts with Hsf to further stabilise Hsf binding to heat shock elements (HSEs).
Taf105 is physically associated with Tbp in vitro and in vivo. Mutation at position 332 of Tbp disrupts the ability of Taf105 to associated with Tbp.
Mutation at position 332 of Tbp renders it inactive for tRNA gene transcription in vitro.
TfIID binds to a conserved downstream basal promoter element (DPE) that is present in many TATA-box deficient promoters. The DPE acts in conjunction with the initiation site sequence to provide a binding site for TfIID in the absence of a TATA box to mediate transcription of TAT-less promoters.
Tbp can be central to both activation and repression mechanisms.
In Schneider S-2 cells Tbp is limiting for the expression of both TATA-containing and TATA-lacking RNA polymerase III promoters.
The tandem Adh promoters are differentially transcribed in the embryo owing to critical differences in the core promoter elements. Reconstituted differential Adh promoter transcription in vitro provides evidence that selective Adh promoter utilization is mediated by a specific Tbp-TAF complex in combination with TfIIA. TAFs in the Tbp complex are required for discrimination between the Adh distal and proximal initiator elements.
Tbp and TfIIB genes share common features in the promoter regions.
A quadruple complex containing Tbp, Taf1, Taf4 and Taf6 mediates transcriptional synergism by bcd and hb, whereas triple Tbp-Taf complexes lacking one or other coactivator failed to support synergistic activation. The concerted action of multiple regulators with different coactivators helps to establish the pattern and level of segmentation gene transcription during development.
eve efficiently blocks, or "squelches", Tbp-enhanced transcription in cotransfected Schneider L2 cells. Squelching does not require eve DNA-binding sites on the reporter plasmids used, but is dependent on the presence of the eve repression domain.
The assembly and purification of various functional Tbp TAF complexes demonstrate that Tbp plus the TAFs is sufficient to replace endogenous TFIID to support activated transcription in vitro.
The role of the two essential transcription components, TfIIIB and TfIIIC, in response to TPA treatment is studied; only TfIIIB activity is increased. Tbp activity is also increased. Results suggest that the induction of transcription is due to an increase in the activity of TfIIIB which results in an increase in the number of functional transcription complexes.
TFIID subunit proteins and the Tbp protein can interact in pairwise combinations with several subunits in a network of interactions within TFIID.
Taf1 contains at least two sites of interaction with Tbp. N terminal sites mediate strong physical interaction with Tbp and inhibit Tbp function. Interaction of the N terminal region with Tbp may directly control TATA-box binding.
Recombinant purified TfIIA-L and TfIIA-S can form a stable complex with Tbp on DNA, the recombinant protein can stimulate basal transcription and enhances transcriptional activation.
Purified Taf5 is unable to bind Tbp directly or to interact strongly with the C-terminal domain of Taf1, but can only interact with a complex containing Tbp, Taf1, Taf4 and Taf6.
Mutations downstream of the TATA element of the Hsp70 promoter reduce the binding of the Tbp gene product.
Purified TfIID, containing endogenous Tbp and at least seven TAFs is necessary and sufficient for Sp1 activation in a reconstituted transcription reaction.
Taf1 gene product has been isolated and characterised and has been shown to interact directly with Tbp.
A number of polypeptides (encoded by Taf1, Taf4, Taf5, Taf6, e(y)1 and Taf12) that are tightly associated with Tbp and are native TFIID components have been purified. Protein blotting experiments suggest that one of these proteins, Taf1, interacts directly with Tbp, while the association between Tbp and the other proteins is either weak or is an indirect association via Taf1.
In vitro expressed Taf4 protein interacts directly with Taf1 which itself interacts with Tbp, a complex of all three is suggested. Binding study with various mutants of Taf1 suggests that both Taf4 and Tbp interact with the N-terminal 352-amino acid portion of Taf1.
TATA complex formation on the Hsp70Bb core promoter shows sequence dependence at the TATA element, at the transcription start site and further downstream. The TATA complex contains Tbp.
There is a weak but reproducible interaction between the products of the Tbp and Taf6 loci in vitro. Tbp, Taf1, Taf4 and Taf6 products can assemble into a mini-complex in vitro, showing that Taf6 and Taf4 occupy distinct binding sites on the C terminal part of Taf1.
See also Dynlacht, Cell 66:563.
TfIID transcription factor is a multiprotein complex including TATA-binding protein (Tbp) and Tbp-associated factors (TAFs). Taf1 has been partially cloned and the assembly of a partial complex containing recombinant Tbp, Taf1 and Taf4 analysed. This triple complex supports activation of HeLa cell Sp1 and reveals specific interactions between Tbp, Taf1 and Taf4.
snRNA:U1:95Ca transcription in vitro requires Tbp.
Overexpression of full length protein in cultured cells can enhance expression dramatically from a weak minimal TATA-containing promoter.
A TATA-dependent protein-DNA complex is found in fractionated embryonic nuclear extracts. DNase I footprint analysis identifies polypeptides (including Taf12, Tbp and RpII140) that require the Hsp70Bb TATA element for binding to regions of the Hsp70Bb promoter.
Origin and Etymology
Discoverer
Etymology
Identification
External Crossreferences and Linkouts ( 58 )
Sequence Crossreferences
NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
Other crossreferences
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
KEGG Genes - Molecular building blocks of life in the genomic space.
KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
modMine - A data warehouse for the modENCODE project
Linkouts
BioGRID - A database of protein and genetic interactions.
DPiM - Drosophila Protein interaction map
DroID - A comprehensive database of gene and protein interactions.
DRSC - Results frm RNAi screens
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyMine - An integrated database for Drosophila genomics
Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
MIST (protein-protein) - An integrated Molecular Interaction Database
Synonyms and Secondary IDs (20)
Reported As
Symbol Synonym
TBP
(Neves and Eisenman, 2019, Cruz-Becerra et al., 2018, Fursova et al., 2018, Sriskanthadevan-Pirahas et al., 2018, Shao and Zeitlinger, 2017, Bayona-Feliu et al., 2016, Cruz-Becerra et al., 2016, Kang et al., 2016, Mendez et al., 2016, Duttke, 2015, Pahi et al., 2015, Wang et al., 2014, Chen et al., 2013, Clark et al., 2013, Guglielmi et al., 2013, Hohmura et al., 2013, Agelopoulos et al., 2012, Lam et al., 2012, Marr et al., 2012, Wu et al., 2012, Cernilogar et al., 2011, Erokhin et al., 2011, Li and Arnosti, 2011, Moiseeva and Tchurikov, 2011, Vorobyeva et al., 2011, Filion et al., 2010, Gurskiy et al., 2010, Park et al., 2010, Theisen et al., 2010, Plata et al., 2009, Vorobyeva et al., 2009, Vorobyeva et al., 2009, Weake et al., 2009, Wright and Tjian, 2009, Aguilar-Fuentes et al., 2008, Barakat and Stumph, 2008, Hsu et al., 2008, Soshnikova et al., 2008, Vorobyeva et al., 2008, Wood et al., 2008, Fregoso et al., 2007, Isogai et al., 2007, Lebedeva et al., 2007, Metcalf and Wassarman, 2007, Wang et al., 2007, Aguilar-Fuentes et al., 2006, Kahn et al., 2006, Katzenberger et al., 2006, Kopytova et al., 2006, Marr et al., 2006, Papp and Muller, 2006, Santoso and Kadonaga, 2006, Wright et al., 2006, Fu and Ma, 2005, Kim and Lis, 2005, Lebedeva, 2005, Lebedeva et al., 2005, Ma, 2005, Choi et al., 2004, Jin et al., 2004, Kim et al., 2004, Hochheimer and Tjian, 2003, Levine and Tjian, 2003, Wang and Brock, 2003, Huang et al., 2002, Leibovitch et al., 2002, Aoyagi and Wassarman, 2001, Hernandez-Hernandez and Ferrus, 2001, Georgieva et al., 2000, Pham and Sauer, 2000, Takada et al., 2000, Breiling et al., 1999, Dantonel et al., 1999, Sandaltzopoulos and Becker, 1998, Veal et al., 1998, Wang and Lindquist, 1998, Zhou et al., 1998, Sauer and Tjian, 1997, Gupta et al., 1996, Kornberg, 1996, Austin and Biggin, 1995, Baek, 1995.8.30, Lira-De Vito et al., 1995, Sauer et al., 1995, ten Harmsel and Biggin, 1995, Um et al., 1995, Burke, 1994.6.30, Goodrich and Tjian, 1994, Weinzierl et al., 1993)
Secondary FlyBase IDs
  • FBgn0013961
  • FBtr0071679
  • FBpp0071596
Datasets (1)
Study focus (1)
Experimental Role
Project
Project Type
Title
  • transgene_used
Protein profiling reveals five principal chromatin types in Drosophila cells.
References (253)