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General Information
Symbol
Dmel\tkv
Species
D. melanogaster
Name
thickveins
Annotation Symbol
CG14026
Feature Type
FlyBase ID
FBgn0003716
Gene Model Status
Stock Availability
Enzyme Name (EC)
Receptor protein serine/threonine kinase (2.7.11.30)
Gene Snapshot
thickveins (tkv) encodes a transforming growth factor beta type I receptor. Together with the product of put, it functions as a receptor of the product of dpp and therefore contributes to the BMP signaling pathway. [Date last reviewed: 2019-06-13]
Also Known As
str, Thickvein, Brk25D, dtfr, l(2)04415
Key Links
Genomic Location
Cytogenetic map
Sequence location
2L:5,219,000..5,271,384 [-]
Recombination map
2-16
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
-
Catalytic Activity (EC)
Experimental Evidence
ATP + [receptor-protein] = ADP + [receptor-protein] phosphate (2.7.11.30)
Predictions / Assertions
-
Summaries
Pathway (FlyBase)
BMP Signaling Pathway Core Components -
The Bone Morphogenetic Protein (BMP) signaling pathway is one of two branches of Transforming Growth Factor-β family signaling in Drosophila. The binding of a BMP family dimer to a heterodimeric serine/threonine kinase receptor complex results in the phosphorylation of Mad, a member of the Smad family. Mad forms a complex with the co-Smad, Med. This complex translocates into the nucleus and regulates the transcription of target genes in concert with other nuclear cofactors. (Adapted from FBrf0236482.)
Gene Group (FlyBase)
TGF-BETA TYPE I RECEPTORS -
The Transforming Growth Factor-β Receptor (TGF-βR) family are transmembrane serine/threonine kinases. They form heterodimeric receptor complexes composed of type I and type II subunits. Upon ligand binding, the constitutively active type II receptor phosphorylates the type I receptor which, in turn, phosphorylates a member of the Smad family. (Adapted from FBrf0236482.)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
tkv: thick veins
thumb
tkv: thick veins
Edith M. Wallace, unpublished.
Two types of mutants have been described, recessive lethals and visibles (viable as adults ). Some of the recessive lethals die as embryos, lacking dorsal hypoderm (Nusslein-Volhard et al., 1984). The wing veins of the viable mutants are thickened and branched in the region of crossveins, near end of L2, and elsewhere. Sometimes there is a blister near the posterior crossvein in female flies; L4 sometimes shortened, especially in females. Expression more extreme at 19 than at higher temperatures and in females than in males. Some heteroallelic combinations are lethal; others are viable with thick veins and thoracic abnormalities (Szidonya and Reuter, 1988b).
Summary (Interactive Fly)
receptor of Decapentaplegic - Wnt ligands regulate Tkv expression to constrain Dpp activity in the Drosophila ovarian stem cell niche - loss of Neurexin and Neuroligin leads to decreased levels of the BMP co-receptor, Thickveins and the downstream effector phosphorylated Mad at the neuromuscular junction synapses - S6 kinase like inhibits neuromuscular junction growth by downregulating the BMP receptor thickveins
Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
4

Please see the GBrowse view of Dmel\tkv or the JBrowse view of Dmel\tkv for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.51
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0079086
2846
563
FBtr0079088
3129
531
FBtr0079087
2885
575
FBtr0079089
3616
509
Additional Transcript Data and Comments
Reported size (kB)
4.4, 3.3 (northern blot)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0078720
62.7
563
6.28
FBpp0078722
59.3
531
6.56
FBpp0078721
64.0
575
5.79
FBpp0078723
57.2
509
7.97
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Comments
put protein binds BMP2 in concert with tkv, forming heteromeric receptor complexes in COS1 cell transient assays.
tkv protein expressed in COS1 cells binds dpp protein and BMP2 with high affinity.
External Data
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\tkv using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (53 terms)
Molecular Function (9 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
inferred from physical interaction with FLYBASE:dpp; FB:FBgn0000490
contributes_to BMP binding
inferred from direct assay
inferred from physical interaction with FLYBASE:Dad; FB:FBgn0020493
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
inferred from electronic annotation with InterPro:IPR017194
(assigned by InterPro )
inferred from biological aspect of ancestor with PANTHER:PTN000583675
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN001147404
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN001147404
(assigned by GO_Central )
inferred from sequence or structural similarity
non-traceable author statement
Biological Process (35 terms)
Terms Based on Experimental Evidence (31 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
(assigned by UniProt )
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:dpp; FB:FBgn0000490
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
Terms Based on Predictions or Assertions (9 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN001147404
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000583675
(assigned by GO_Central )
non-traceable author statement
inferred from biological aspect of ancestor with PANTHER:PTN001147404
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN002758232
(assigned by GO_Central )
Cellular Component (9 terms)
Terms Based on Experimental Evidence (8 terms)
CV Term
Evidence
References
colocalizes_withcolocalizes_with cytoneme
inferred from direct assay
inferred from high throughput direct assay
inferred from direct assay
inferred from direct assay
inferred from high throughput direct assay
inferred from direct assay
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
inferred from sequence or structural similarity
inferred from biological aspect of ancestor with PANTHER:PTN002758232
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000583675
(assigned by GO_Central )
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
distribution deduced from reporter
Stage
Tissue/Position (including subcellular localization)
Reference
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
organism

Comment: maternally deposited

northern blot
Stage
Tissue/Position (including subcellular localization)
Reference

Comment: reference states 0-12 hr AEL

Additional Descriptive Data
tkv is expressed along the anterior and posterior sides of the wing pouch; expression is excluded from a wide vertical band perpendicular to the D/V boundary in the middle of the wing pouch. tkv is expressed throughout the presumptive capitellum (haltere pouch).
Expression is observed in the anterior midline glial cells.
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
colocalizes_withcolocalizes_with cytoneme
inferred from direct assay
inferred from high throughput direct assay
inferred from direct assay
inferred from direct assay
inferred from high throughput direct assay
inferred from direct assay
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\tkv in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 48 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 76 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of tkv
Transgenic constructs containing regulatory region of tkv
Deletions and Duplications ( 58 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
adherens junction & embryonic dorsal trunk, with Scer\GAL4btl.B123
adherens junction & embryonic dorsal trunk, with Scer\GAL4btl.PS
adult head & cuticle | somatic clone
dorsal mesothoracic disc & actin filament | somatic clone
dorsal mesothoracic disc & microtubule | apical | somatic clone
leg & adult cuticle | somatic clone
leg & sex comb | ectopic
scutum & macrochaeta, with Scer\GAL4Act5C.PI
scutum & macrochaeta, with Scer\GAL4hs.PB
scutum & macrochaeta, with Scer\GAL4tsh-Gal4-1
sensory mother cell & dorsal mesothoracic disc, with Scer\GAL4hs.PB
sensory mother cell & dorsal mesothoracic disc, with Scer\GAL4tsh-Gal4-1
visceral mesoderm & parasegment 7
wing & adult cuticle | somatic clone
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (7)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
12 of 15
Yes
Yes
 
10 of 15
Yes
No
3 of 15
No
No
2 of 15
No
No
 
2 of 15
No
No
1 of 15
No
No
 
1 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (7)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
12 of 15
Yes
Yes
11 of 15
Yes
No
3 of 15
No
No
2 of 15
No
No
2 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Rattus norvegicus (Norway rat) (9)
8 of 13
Yes
Yes
7 of 13
No
Yes
3 of 13
No
No
2 of 13
No
No
2 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
Yes
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (7)
10 of 12
Yes
Yes
6 of 12
No
Yes
3 of 12
No
No
2 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
Danio rerio (Zebrafish) (11)
10 of 15
Yes
Yes
9 of 15
Yes
No
6 of 15
No
Yes
3 of 15
No
Yes
3 of 15
No
No
3 of 15
No
No
2 of 15
No
No
2 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (2)
13 of 15
Yes
Yes
3 of 15
No
No
Arabidopsis thaliana (thale-cress) (6)
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG0919053I )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091503IM )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W05EX )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bombyx mori
Silkmoth
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Heliconius melpomene
Postman butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis florea
Little honeybee
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Apis mellifera
Western honey bee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus impatiens
Common eastern bumble bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Bombus terrestris
Buff-tailed bumblebee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Linepithema humile
Argentine ant
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Nasonia vitripennis
Parasitic wasp
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Dendroctonus ponderosae
Mountain pine beetle
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Tribolium castaneum
Red flour beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Pediculus humanus
Human body louse
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Cimex lectularius
Bed bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X05B2 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Strigamia maritima
European centipede
Strigamia maritima
European centipede
Strigamia maritima
European centipede
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0BIU )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (4)
5 of 10
4 of 10
2 of 10
2 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 2 )
Allele
Disease
Evidence
References
Potential Models Based on Orthology ( 3 )
Modifiers Based on Experimental Evidence ( 2 )
Allele
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Interactions
Summary of Physical Interactions
esyN Network Diagram
Show neighbor-neighbor interactions:
Select Layout:
Legend:
Protein
RNA
Selected Interactor(s)
Interactions Browser

Please see the Physical Interaction reports below for full details
RNA-RNA
Physical Interaction
Assay
References
RNA-protein
Physical Interaction
Assay
References
protein-protein
Physical Interaction
Assay
References
Summary of Genetic Interactions
esyN Network Diagram
esyN Network Key:
Suppression
Enhancement

Please look at the allele data for full details of the genetic interactions
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
suppressible
suppressible
suppressible
suppressible
suppressible
suppressible
enhanceable
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
suppressible
suppressible
suppressible
External Data
Linkouts
BioGRID - A database of protein and genetic interactions.
DroID - A comprehensive database of gene and protein interactions.
InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
MIST (genetic) - An integrated Molecular Interaction Database
MIST (protein-protein) - An integrated Molecular Interaction Database
Pathways
Gene Group - Pathway Membership (FlyBase)
BMP Signaling Pathway Core Components -
The Bone Morphogenetic Protein (BMP) signaling pathway is one of two branches of Transforming Growth Factor-β family signaling in Drosophila. The binding of a BMP family dimer to a heterodimeric serine/threonine kinase receptor complex results in the phosphorylation of Mad, a member of the Smad family. Mad forms a complex with the co-Smad, Med. This complex translocates into the nucleus and regulates the transcription of target genes in concert with other nuclear cofactors. (Adapted from FBrf0236482.)
External Data
Linkouts
KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
SignaLink - A signaling pathway resource with multi-layered regulatory networks.
Genomic Location and Detailed Mapping Data
Chromosome (arm)
2L
Recombination map
2-16
Cytogenetic map
Sequence location
2L:5,219,000..5,271,384 [-]
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
25D1-25D2
Limits computationally determined from genome sequence between P{lacW}l(2)k11206k11206 and P{lacW}tkvk16713&P{lacW}l(2)k01302k01302
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
25D1-25D2
(determined by in situ hybridisation)
25D-25D
(determined by in situ hybridisation)
Experimentally Determined Recombination Data
Left of (cM)
Right of (cM)
Notes
Maps adjacent to Bsg25D.
Stocks and Reagents
Stocks (48)
Genomic Clones (28)
cDNA Clones (73)
 

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequences
BDGP DGC clones
Other clones
Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)
RNAi and Array Information
Linkouts
DRSC - Results frm RNAi screens
GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
Antibody Information
Laboratory Generated Antibodies
 
Commercially Available Antibodies
 
Other Information
Relationship to Other Genes
Source for database identify of
Source for database merge of
Additional comments
Other Comments
The tkv product negatively regulates dac expression in the embryonic head.
The Ubx and dpp products collaborate to repress the tkv repressor, sbb, in the haltere disc. The resulting increased amounts of tkv receptor decrease dpp mobility in the haltere.
When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, a whole range of mitotic abnormalities, spindle abnormalities, chromosome abnormalities, chromosome alignment defects and polyploid cells are seen.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
One of five genes identified as encoding downstream components of the dpp signalling cascade which is necessary for blocking salivary gland gene activation by Scr in the dorsal region of parasegment 2.
Mef2 plays a role in the regulation of expression of tkv.
Loss of function alleles of tkv, put, Mad, Med and shn suppress the CycEJP mutant eye phenotype in combination with dppd-ho.
dpp signalling negatively regulates tkv expression. The level of receptor influences the effective range of the dpp gradient. High levels of tkv sensitize cells to low levels of dpp and limit the movement of dpp outside the wing pouch.
dpp/tkv signaling is obligatorily required, while scw/sax signaling is necessary but not sufficient for dorsal patterning in the embryo.
The th and Iap2 proteins associate with the tkv receptor in vivo.
tkv has a crucial function in mediating dpp-dependent tin activation and dorsal mesoderm induction.
vvl is required for the specific expression in the tracheal cells of tkv and rho. tkv acts autonomously in the tracheal cells directing their correct migration.
Mad protein functions downstream of the serine-threonine kinase activity of the tkv receptor.
sax and tkv interact with the same developmental pathways required for proper anterior posterior patterning of the wing.
dpp receptors tkv and put are not required for photoreceptor cell differentiation. tkv and put play a nonessential role in morphogenetic furrow progression, but are required for initiation of the furrow at the posterior margin. tkv and dpp mutant clones reveal a role for dpp in the early growth of the eye imaginal disc. Ectopic activation of the dpp pathway does not lead to ectopic neuronal differentiation.
dpp receptors put and tkv, or the shn transcription factor, are autonomously required for cell proliferation in the entire developing wing. The dpp signal has to travel several cell diameters from its source in order to reach all cells that require its signal.
The autosomal "FLP-DFS" technique (using the P{ovoD1-18} P{FRT(whs)} P{hsFLP} chromosomes) has been used to identify the specific maternal effect phenotype for the zygotic lethal mutation.
tkv is essential to establish the lateral trunk branches.
thv mutations enhance the weak dpp mutations.
Genetic interactions and the strikingly similar phenotypes in shn and dpp receptors encoded by tkv and put suggest the shn plays a downstream role in dpp signalling.
put and tkv encode type II and type I receptors, both act in concert to mediate all known dpp signalling processes in the developing midgut.
The requirements for tkv in dorsal closure, visceral mesoderm and trachea development assign novel functions to dpp or a closely related member of the TGFβ superfamily.
tkv encodes a dpp receptor. There is at least partial overlap of function of the sax and tkv receptors in vivo.
Specification of distinct cell fates in response to different concentrations of dpp product may be achieved combinatorially by the sax and tkv receptors. tkv is required for patterning the entire domain of the presumptive embryonic ectoderm normally specified by dpp.
tkv has been cloned and sequenced, and its expression pattern has been analysed.
Isolated in a PCR screen for receptor protein serine/threonine kinase candidates.
Maternal germline clonal analysis reveals tkv is lethal in the germline, results are consistent with the idea that tkv function is required for oogenesis. A reduction of the tkv product maternally results in partially ventralised embryos, the degree of ventralisation increases as the zygotic tkv product is also reduced. Interactions with dorsoventral patterning genes demonstrates tkv plays a role in establishing dorsoventral patterning.
Mutations in tkv cause thickened veins.
In the loss-of-function alleles of tkv, N and Dl, thickened veins and occasional plexi are seen, associated with small wings. In the gain-of-function alleles the reciprocal phenotype is seen, associated with large wings. The 'Notch' phenotypic group includes neurogenetic mutations involved in cell communications. Some alleles are embryonic lethal.
Two types of mutants have been described, recessive lethals and visibles (viable as adults). Some of the recessive lethals die as embryos, lacking dorsal hypoderm (Nusslein-Volhard et al., 1984). The wing veins of the viable mutants are thickened and branched in the region of crossveins, near end of L2 and elsewhere. Sometimes there is a blister near the posterior crossvein in female flies; L4 sometimes shortened, especially in females. Expression more extreme at 19oC than at higher temperatures and in females than in males. Some heteroallelic combinations are lethal; others are viable with thick veins and thoracic abnormalities (Szidonya and Reuter, 1988).
Origin and Etymology
Discoverer
Etymology
Identification
External Crossreferences and Linkouts ( 92 )
Sequence Crossreferences
NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
Other crossreferences
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
KEGG Genes - Molecular building blocks of life in the genomic space.
KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
modMine - A data warehouse for the modENCODE project
Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
SignaLink - A signaling pathway resource with multi-layered regulatory networks.
Linkouts
ApoDroso - Functional genomic database for photoreceptor development, survival and function
BioGRID - A database of protein and genetic interactions.
DPiM - Drosophila Protein interaction map
DroID - A comprehensive database of gene and protein interactions.
DRSC - Results frm RNAi screens
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyMine - An integrated database for Drosophila genomics
Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
MIST (genetic) - An integrated Molecular Interaction Database
MIST (protein-protein) - An integrated Molecular Interaction Database
Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
Synonyms and Secondary IDs (32)
Reported As
Symbol Synonym
Atr25D
Dtfr
STK-A
Tkv
(Kim et al., 2019, Lu et al., 2019, Wang et al., 2019, Chandran et al., 2018, Fan et al., 2018, Follansbee et al., 2017, Li et al., 2017, Martins et al., 2017, Monsivais et al., 2017, Romero-Pozuelo et al., 2017, Song et al., 2017, Upadhyay et al., 2017, Wells et al., 2017, Zhang et al., 2017, Ashe, 2016, Jiang et al., 2016, Mbodj et al., 2016, Quijano et al., 2016, Sharifkhodaei et al., 2016, Urrutia et al., 2016, Yadav et al., 2016, Amoyel and Bach, 2015, Beich-Frandsen et al., 2015, Bier and De Robertis, 2015, Charbonnier et al., 2015, Denes et al., 2015, Fried and Iber, 2015, Hariharan, 2015, Irvine and Harvey, 2015, Lo et al., 2015, Sawala et al., 2015, West et al., 2015, Zhou et al., 2015, Aleman et al., 2014, Corrigan et al., 2014, Kornberg and Roy, 2014, Oh et al., 2014, Bausek, 2013, Doumpas et al., 2013, Garcia et al., 2013, Li et al., 2013, Mbodj et al., 2013, Wong et al., 2013, Lim et al., 2012, Raftery and Umulis, 2012, Smith et al., 2012, Ben-Zvi et al., 2011, Eivers et al., 2011, Eliazer and Buszczak, 2011, Erickson, 2011, Harris and Ashe, 2011, Kaneko et al., 2011, Lander et al., 2011, Oh and Irvine, 2011, Schwank et al., 2011, Takemura and Adachi-Yamada, 2011, Wartlick et al., 2011, Ball et al., 2010, Chen and Xu, 2010, Chen et al., 2010, Djiane and Mlodzik, 2010, Higashi-Kovtun et al., 2010, Kim et al., 2010, Umulis et al., 2010, Guo and Wang, 2009, Lander et al., 2009, Martinez et al., 2009, Merino et al., 2009, Akiyama et al., 2008, Estella et al., 2008, Kamiya et al., 2008, Lembong et al., 2008, Miles et al., 2008, Serpe et al., 2008, Yao et al., 2008, Yao et al., 2008, Zeng et al., 2008, Hatton-Ellis et al., 2007, Johnson et al., 2007, O'Keefe et al., 2007, Pistillo and Desplan, 2007, Wang et al., 2007, Xu et al., 2007, Yakoby et al., 2007, Zeng et al., 2007, Bangi and Wharton, 2006, Bokel et al., 2006, Bokel et al., 2006, Collins et al., 2006, Dudu, 2006, Dudu et al., 2006, Gao and Laughon, 2006, Giebel and Wodarz, 2006, Philippakis et al., 2006, Stern, 2006, Umulis et al., 2006, Yao et al., 2006, Stathopoulos and Levine, 2005, Yamashita et al., 2005, Bharathi et al., 2004, Gonzalez-Gaitan, 2003, Jekely and Rorth, 2003, Martin-Castellanos and Edgar, 2002, Bartoszewski et al., 2001, Stathakis et al., 2000)
l(2)25Da
tkv
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Name Synonyms
Activin-A-receptor-25D
BMP receptor kinase 25D
DPP receptor
Thick-veins
Secondary FlyBase IDs
  • FBgn0010572
Datasets (0)
Study focus (0)
Experimental Role
Project
Project Type
Title
References (957)