FlyBase Gene Report: Dmel\tkv

embryonic midgut chamber 4

wing pouch | restricted

Comment: distant from A/P boundary

(Makhijani et al., 2007)

presumptive capitellum

(Makhijani et al., 2007)

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

(Okano et al., 1994)

organism

(Okano et al., 1994)

embryonic midgut constriction 1

(Okano et al., 1994)

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 1 -- 4

organism | ubiquitous

(Okano et al., 1994, Penton et al., 1994)

embryonic stage 3 -- 4

organism | dorsal ventral gradient

(Okano et al., 1994)

embryonic stage 4

(Brummel et al., 1994)

embryonic stage 4 -- 6

anlage in statu nascendi

(Fisher et al., 2012)

central brain anlage in statu nascendi

(Fisher et al., 2012)

dorsal ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

foregut anlage in statu nascendi

(Fisher et al., 2012)

head mesoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

mesoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

visual anlage in statu nascendi

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

trunk mesoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

ventral ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

antennal anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

dorsal head epidermis anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

embryonic stage 5

(Brummel et al., 1994)

epidermis | dorsal

(Affolter et al., 1994)

ectoderm | dorsal

(Penton et al., 1994)

embryonic stage 6

(Okano et al., 1994)

embryonic stage 6 -- 7

mesoderm | ventral

(Brummel et al., 1994)

embryonic stage 6 -- 9

mesoderm

(Affolter et al., 1994)

embryonic stage 6 -- 12

mesoderm

(Okano et al., 1994)

embryonic stage 7

ectoderm | lateral

(Brummel et al., 1994)

embryonic stage 7 -- 8

head mesoderm

(Fisher et al., 2012)

dorsal head epidermis primordium

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

ventral ectoderm

(Fisher et al., 2012)

mesectoderm anlage

(Kearney et al., 2004)

embryonic stage 8

ventral neurectoderm

(Brummel et al., 1994)

embryonic stage 9

mesoderm

(Penton et al., 1994)

embryonic stage 9 -- 10

antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

dorsal ectoderm

(Fisher et al., 2012)

head mesoderm

(Fisher et al., 2012)

mesectoderm

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

ventral ectoderm

(Fisher et al., 2012)

ventral nerve cord primordium

(Fisher et al., 2012)

embryonic stage 10

ectoderm | dorsal

(Brummel et al., 1994)

embryonic stage 10 -- 11

embryonic/larval tracheal section

(Chung et al., 2011)

embryonic stage 11

tracheal pit

(Okano et al., 1994)

tracheal primordium

(Affolter et al., 1994)

embryonic stage 12 -- 17

anterior midgut primordium

(Okano et al., 1994)

posterior midgut primordium

(Okano et al., 1994)

embryonic/larval midgut

(Okano et al., 1994)

embryonic stage 13 -- 16

embryonic/larval posterior midgut

(Brummel et al., 1994)

embryonic/larval anterior midgut

(Brummel et al., 1994)

embryonic/larval pharynx

(Brummel et al., 1994)

larval foregut atrium

(Fisher et al., 2012)

embryonic dorsal apodeme

(Fisher et al., 2012)

embryonic dorsal epidermis

(Fisher et al., 2012)

embryonic epipharynx

(Fisher et al., 2012)

embryonic foregut

(Fisher et al., 2012)

embryonic head epidermis

(Fisher et al., 2012)

embryonic hindgut

(Fisher et al., 2012)

embryonic hypopharynx

(Fisher et al., 2012)

embryonic midgut chamber

(Fisher et al., 2012)

embryonic rectum

(Fisher et al., 2012)

embryonic ventral apodeme

(Fisher et al., 2012)

embryonic ventral epidermis

(Fisher et al., 2012)

embryonic/larval tracheal dorsal trunk

(Fisher et al., 2012)

embryonic/larval midgut

(Fisher et al., 2012)

embryonic/larval posterior spiracle

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

midline glial cell

Comment: AMG

(Kearney et al., 2004)

embryonic stage 13 -- 17

visceral trunk mesoderm

(Affolter et al., 1994)

embryonic stage 16

gastric caecum

(Penton et al., 1994)

embryonic/larval proventriculus

(Penton et al., 1994)

embryonic midgut chamber 1

(Penton et al., 1994)

embryonic/larval hindgut

(Penton et al., 1994)

embryonic midgut chamber 4

(Penton et al., 1994)

larval stage

eye-antennal disc

(Brummel et al., 1994)

leg disc

(Brummel et al., 1994)

wing disc

(Brummel et al., 1994)

imaginal disc

(Brummel et al., 1994)

eye disc morphogenetic furrow

(Brummel et al., 1994)

centripetal follicle cell

wing disc | restricted

(Haerry et al., 1998)

adult stage & oogenesis

(Brummel et al., 1994)

nurse cell

(Brummel et al., 1994)

oogenesis stage S8 -- S10 & adult stage | female

oocyte

(Vreede et al., 2013)

oogenesis stage S10

follicle cell | anterior | restricted

(Yakoby et al., 2008)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

(Okano et al., 1994)

embryonic stage 1 -- 15

Comment: reference states 0-12 hr AEL

(Okano et al., 1994)

Additional Descriptive Data

In stage 10B egg chambers, tkv is expressed in a dorsoventral pattern with two lateral patches on both sides of the

(Yakoby et al., 2008)

dorsal midline.

(Yakoby et al., 2008)

tkv is expressed along the anterior and posterior sides of the wing pouch; expression is excluded from a wide vertical band perpendicular to the D/V boundary in the middle of the wing pouch. tkv is expressed throughout the presumptive capitellum (haltere pouch).

(Makhijani et al., 2007)

Expression is observed in the anterior midline glial cells.

(Kearney et al., 2004)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic/larval neuromuscular junction

• terminal bouton

(Higashi-Kovtun et al., 2010)

embryonic/larval neuromuscular junction

• postsynaptic membrane

(Higashi-Kovtun et al., 2010)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

part_of BMP receptor complex

inferred from physical interaction with FLYBASE:wit; FB:FBgn0024179

(Lee-Hoeflich et al., 2005)

colocalizes_with cytoneme

inferred from direct assay

(Roy et al., 2014, Roy et al., 2011)

located_in cytosol

inferred from high throughput direct assay

(Lye et al., 2014)

located_in early endosome

inferred from direct assay

(Smith et al., 2012)

located_in multivesicular body

inferred from direct assay

(Bokel et al., 2006)

located_in plasma membrane

inferred from high throughput direct assay

(Lye et al., 2014)

inferred from direct assay

(Penton et al., 1994)

located_in presynapse

inferred from direct assay

(Banerjee et al., 2017)

Expression Deduced from Reporters

Reporter: P{lacW}tkv^k16713

Stage

Tissue/Position (including subcellular localization)

Reference

wing disc | restricted

(del Alamo Rodriguez et al., 2004)

wing pouch | restricted

Comment: distant from A/P boundary

(Makhijani et al., 2007)

presumptive capitellum

(Makhijani et al., 2007)

air sac primordium | gradient

(Roy et al., 2014)

Reporter: P{PZ}tkv^P906

Stage

Tissue/Position (including subcellular localization)

Reference

wing pouch | restricted

Comment: distant from A/P boundary

(Makhijani et al., 2007)

presumptive capitellum

(Makhijani et al., 2007)

pupal stage P6

wing disc | restricted

Comment: less at longitudinal veins and posterior crossvein

(Conley et al., 2000)

Reporter: PBac{544.SVS-1}tkv^CPTI002487

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic/larval CNS perineurial glial cell of eye disc

eye disc | restricted

(Yuva-Aydemir et al., 2011)

(Yuva-Aydemir et al., 2011)

adult brain cell body rind

larval neuron of larval ventral nerve cord | medial

(Li et al., 2016)

adult stage

(Knowles-Barley, 2011.8.24)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\tkv in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\tkv

View exonic expression by tissue for Dmel\tkv

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0003716

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

33753/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0003716

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0003716

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0003716

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG14026

Flygut - An atlas of the Drosophila adult midgut

FBgn0003716

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\tkv

Stages(s) 1-3
Stages(s) 4-6
Stages(s) 7-8
Stages(s) 9-10
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 72 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 91 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of tkv

Transgenic constructs containing regulatory region of tkv

Aberrations (Deficiencies and Duplications) ( 58 )

Inferred from experimentation ( 58 )

Gene disrupted in

Df(2L)BSC693

(Kahsai et al., 2016, Christensen et al., 2008.12.28)

Df(2L)cl1

(BDGP Project Members, 1994-1999, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988, Kotarski et al., 1983)

Df(2L)cl2

(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988, Kotarski et al., 1983)

Df(2L)cl-h1

(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)

Df(2L)cl-h3

(Spradling et al., 1999, Harbecke and Lengyel, 1995, BDGP Project Members, 1994-1999, Nellen et al., 1994)

Df(2L)Exel6011

(Ryder, 2004.4.26)

Df(2L)Gpdh1-A

(Harbecke and Lengyel, 1995)

Df(2L)sc19-4

(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)

Df(2L)sc19-5

(Nellen et al., 1994, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)

Df(2L)sc19-12

(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)

Df(2L)tkv2

(Spradling et al., 1999, George and Terracol, 1997, Morimura et al., 1996, BDGP Project Members, 1994-1999, Terracol and Lengyel, 1994, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988, Reuter and Szidonya, 1983)

Df(2L)tkv3

(Kahsai and Cook, 2018, George and Terracol, 1997, BDGP Project Members, 1994-1999, Nellen et al., 1994, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988, Reuter and Szidonya, 1983)

In(2L)tkv^Sz-1

(George and Terracol, 1997)

T(Y;2)B137

(Kotarski et al., 1983)

Tp(2;3)tkv

(George and Terracol, 1997, Reuter and Szidonya, 1983)

Ts(YLt;2Lt)P51+Ts(YSt;2Rt)B137

(Kotarski et al., 1983)

Gene not disrupted in

Df(2L)2802

(Kotarski et al., 1983)

Df(2L)cl7

(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988, Kotarski et al., 1983)

Df(2L)cl-h2

(Nellen et al., 1994, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)

Df(2L)cl-h3

(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)

Df(2L)cl-h4

(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)

Df(2L)dp-h25

(Bryant et al., 1988)

Df(2L)dp-h28

(Bryant et al., 1988)

Df(2L)ed1

(Bryant et al., 1988, Reuter and Szidonya, 1983)

Df(2L)ed2

(Reuter and Szidonya, 1983)

Df(2L)Gpdh1-75

(Kotarski et al., 1983)

Df(2L)Gpdh1-78

(Kotarski et al., 1983)

Df(2L)Gpdh1-A

(Kotarski et al., 1983)

Df(2L)M24F11

(Bryant et al., 1988, Reuter and Szidonya, 1983)

Df(2L)M24F-B

(Bryant et al., 1988, Reuter and Szidonya, 1983)

Df(2L)sc19-1

(Nellen et al., 1994, Bryant et al., 1988, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)

Df(2L)sc19-3

(Bryant et al., 1988)

Df(2L)sc19-6

(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)

Df(2L)sc19-7

(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)

Df(2L)sc19-8

(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)

T(Y;2)P8

(Reuter and Szidonya, 1983)

Gene not duplicated in

Inferred from location ( 4 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

FlyBase_internaltransgene_features:cell lethal:cell lethal | somatic clone

tkv⁷

cell lethal | recessive | somatic clone

tkv⁴

lethal

lethal, with Scer\GAL4^Act5C.PU

lethal, with Scer\GAL4^pnr-MD237

lethal (with Df(2L)BSC693)

tkv⁸

lethal (with tkv³)

tkv⁸

lethal (with tkv⁴)

tkv⁸

lethal (with tkv⁸)

lethal | larval stage | recessive

tkv⁰⁴⁴¹⁵

lethal | recessive

lethal - all die before end of larval stage (with tkv¹)

tkv⁷

lethal - all die before end of larval stage (with tkv⁷)

tkv¹

lethal - all die before end of pupal stage | heat sensitive, with Scer\GAL4^Ser.PGF

tkv^{Q253D.UAS.cLa}

lethal - all die during embryonic stage

lethal - all die during embryonic stage | germline clone | recessive | rescuable maternal effect

lethal - all die during embryonic stage | maternal effect

tkv⁴

lethal - all die during embryonic stage | recessive

lethal - all die during embryonic stage | semidominant | heat sensitive

tkv^Sz-1

partially lethal, with Scer\GAL4^ple.PF

tkv^NIG.14026R

partially lethal - majority die, with Scer\GAL4^Mef2.PU

tkv^CA.UAS

partially lethal - majority die, with Scer\GAL4^pnr-MD237

partially lethal - majority die | cell autonomous | somatic clone

tkv⁴

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

viable, with Scer\GAL4^Mef2.PR

viable, with Scer\GAL4^tin.CΔ4

tkv^GD2549

viable (with Df(2L)BSC693)

tkv^k01302

viable (with tkv¹)

tkv⁸

viable (with tkv⁸)

tkv¹

Sterility

Allele

female semi-sterile, with Scer\GAL4^{VP16.mat.αTub67C}

tkv^GL01338

female semi-sterile, with Scer\GAL4^{VP16.nanos.UTR}, Scer\GAL4^VP16.otu, Scer\GAL4^nanos.PG

tkv^GL00035

female sterile, with Scer\GAL4^{VP16.mat.αTub67C}

female sterile, with Scer\GAL4^{VP16.nanos.UTR}

tkv^Q253D.UASp

fertile

fertile | female limited

sterile | male limited

Other Phenotypes

Allele

abnormal cell cycle | adult stage | virgin male, with Scer\GAL4^esg.PU

tkv^{Q253D.UAS.cNb}

abnormal cell number | embryonic stage, with Scer\GAL4^how-24B

tkv^CA.UAS.cUa

abnormal cell number | oogenesis, with Scer\GAL4^C587

abnormal cell shape | third instar larval stage, with Scer\GAL4^ap-md544

tkv^UAS.cNa

abnormal circadian rhythm, with Scer\GAL4^P2.4.Pdf

tkv^KK102319

abnormal immune response | adult stage, with Scer\GAL4^esg.PU, Scer\GAL80^Su(H).GBE

tkv^GD2549

abnormal mitotic cell cycle | somatic clone

tkv⁸

abnormal neuroanatomy

tkv^unspecified

abnormal neuroanatomy, with Scer\GAL4^elav.PLu

tkv^{1AΔGS.UAS.Tag:HA}

abnormal neuroanatomy (with tkv¹)

abnormal neuroanatomy (with tkv⁷)

abnormal neuroanatomy (with tkv⁸)

tkv¹

abnormal neuroanatomy (with tkv^k16713)

tkv⁷

abnormal neuroanatomy | adult stage | RU486 conditional, with Scer\GAL4^{elav.Switch.PO}

tkv^CA.UAS

abnormal neuroanatomy | larval stage, with Scer\GAL4^elav-C155

tkv^{Q199D.UAS.Tag:HA}

abnormal neuroanatomy | somatic clone | third instar larval stage, with Scer\GAL4^elav.PH

tkv^{Q199D.UAS.Tag:HA}

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^elav-C155

tkv^CA.UAS

abnormal neuroanatomy | third instar larval stage (with tkv⁸)

tkv^k16713

abnormal neuroanatomy | third instar larval stage (with tkv^k16713)

tkv⁸

abnormal neurophysiology, with Scer\GAL4^ChAT.7.4

tkv^{Q199D.UAS.Tag:HA}

abnormal neurophysiology (with tkv¹)

tkv⁸

abnormal neurophysiology (with tkv⁸)

tkv¹

abnormal neurophysiology | larval stage, with Scer\GAL4^BG380

tkv^{Q199D.UAS.Tag:HA}

abnormal proboscis extension reflex, with Scer\GAL4^ple.PF

tkv^NIG.14026R

abnormal size | adult stage, with Scer\GAL4^dsx.KI

abnormal size | adult stage, with Scer\GAL4^esg.PU

abnormal size | adult stage, with Scer\GAL4^NP0261

tkv^{Q199D.UAS.Tag:HA}

abnormal size | larval stage | somatic clone

tkv⁸

abnormal size | larval stage | somatic clone, with Scer\GAL4^Act5C.PP

tkv^{Q253D.UAS.cNb}

decreased cell size | adult stage, with Scer\GAL4^esg.PU

tkv^GD2549

decreased occurrence of cell division | adult stage | conditional, with Scer\GAL4^esg.PU

tkv^{Q253D.UAS.cNb}

decreased occurrence of cell division | adult stage | conditional, with Scer\GAL4^esg.PU, Scer\GAL80^Su(H).GBE

tkv^GD2549

decreased occurrence of cell division | larval stage | somatic clone

tkv⁸

decreased occurrence of cell division | oogenesis

tkv⁸

decreased occurrence of cell division | somatic clone | third instar larval stage

tkv⁴

decreased size | larval stage | recessive | somatic clone

hyperplasia, with Scer\GAL4^C-765

tkv^{Q253D.UAS.cNb}

hyperplasia, with Scer\GAL4^GMR24H06

tkv^GD2549

hyperplasia | adult stage

tkv^S238A.ca.bam

hyperplasia | adult stage, with Scer\GAL4^{VP16.nanos.UTR}

tkv^ca.UASp

hyperplasia | oogenesis, with Scer\GAL4^{VP16.nanos.UTR}

tkv^Q253D.UASp

hyperplasia | somatic clone

hypoplasia | somatic clone, with Scer\GAL4^Tub.PU

tkv^ca.UASp

increased cell death, with Scer\GAL4^{VP16.nanos.UTR}

tkv^{Q253D.UAS.cNb}

increased cell death | embryonic stage

tkv⁷

increased cell death | embryonic stage, with Scer\GAL4^how-24B

increased cell death | larval stage | recessive | somatic clone

tkv^C97R-mCherry

increased cell death | somatic clone | third instar larval stage, with Scer\GAL4^{Act5C.Switch.PR}

tkv^{Q253D.UAS.cNc}

increased cell death | third instar larval stage, with Scer\GAL4^en-e16E

tkv^HMS02185

increased cell growth rate | adult stage | male, with Scer\GAL4^esg.PU

tkv^{Q253D.UAS.cNb}

increased cell number | adult stage, with Scer\GAL4^esg.PU

tkv^GD2549

increased cell number | adult stage | somatic clone

increased cell number | cell autonomous | somatic clone, with Scer\GAL4^Act5C.PP

tkv^{Q253D.UAS.cNc}

increased cell number | cell non-autonomous | somatic clone | third instar larval stage, with Scer\GAL4^{Act5C.Switch.PR}

increased cell number | oogenesis, with Scer\GAL4^nanos.PU

tkv^QD.UAS.cUa

increased cell number | oogenesis, with Scer\GAL4^{VP16.nanos.UTR}

tkv^Q199D.UASp

increased cell number | somatic clone, with Scer\GAL4^FRT.Act5C

tkv^{Q253D.UAS.cNc}

increased cell number | somatic clone | third instar larval stage, with Scer\GAL4^{Act5C.Switch.PR}

increased cell size, with Scer\GAL4^dsx.KI

tkv^{Q199D.UAS.Tag:HA}

increased mortality | pupal stage | somatic clone, with Scer\GAL4^Act5C.PP

tkv^{Q253D.UAS.cNc}

increased occurrence of cell division, with Scer\GAL4^C-765

tkv^{Q253D.UAS.cNb}

increased occurrence of cell division | adult stage, with Scer\GAL4^esg.PU

tkv^GD2549

increased occurrence of cell division | adult stage | conditional, with Scer\GAL4^esg.PU, Scer\GAL80^Su(H).GBE

tkv^GD2549

increased occurrence of cell division | cell autonomous | somatic clone | third instar larval stage, with Scer\GAL4^{Act5C.Switch.PR}

tkv^{Q253D.UAS.cNc}

increased occurrence of cell division | cell non-autonomous | somatic clone | third instar larval stage, with Scer\GAL4^{Act5C.Switch.PR}

tkv^{Q253D.UAS.cNc}

increased occurrence of cell division | larval stage | somatic clone, with Scer\GAL4^Act5C.PP

tkv^{Q253D.UAS.cNc}

increased occurrence of cell division | spermatogenesis, with Scer\GAL4^Act5C.PI

tkv^{Q253D.UAS.cNb}

increased occurrence of cell division | third instar larval stage, with Scer\GAL4^{Act5C.Switch.PR}

tkv^{DE-Q199D.UAS.Tag:HA}

increased size | larval stage

tkv¹²

increased size | larval stage | recessive | somatic clone

neoplasia | adult stage | somatic clone, with Scer\GAL4^Act5C.PP

tkv^{Q253D.UAS.cNc}

short lived | conditional, with Scer\GAL4^esg.PU, Scer\GAL80^Su(H).GBE

tkv^GD2549

some die during embryonic stage

some die during embryonic stage | maternal effect

tkv⁴

some die during embryonic stage | recessive

some die during embryonic stage | recessive | rescuable maternal effect

some die during embryonic stage | rescuable maternal effect

tkv⁰⁴⁴¹⁵

some die during embryonic stage | semidominant | heat sensitive

tkv^Sz-1

some die during larval stage (with tkv¹)

tkv⁷

some die during larval stage (with tkv⁷)

tkv¹

some die during pupal stage, with Scer\GAL4^pnr-MD237

some die during pupal stage | heat sensitive, with Scer\GAL4^Ser.PGF

tkv^{Q253D.UAS.cLa}

visible

visible, with Scer\GAL4^71B

tkv^CA.UAS

visible, with Scer\GAL4^A9

visible, with Scer\GAL4^Act5C.PI

visible, with Scer\GAL4^ap-md544

tkv^{1AΔGS.UAS.Tag:HA}

visible, with Scer\GAL4^Bx-MS1096

tkv^{1AΔGS.UAS.Tag:HA}

visible, with Scer\GAL4^C-765

tkv^RNAi.UAS.cUa

visible, with Scer\GAL4^cad-em459

tkv^{Q253D.UAS.cNb}

visible, with Scer\GAL4^dpp.blk1

visible, with Scer\GAL4^en-e16E

tkv^UAS.Tag:HA

visible, with Scer\GAL4^GMR.PF

visible, with Scer\GAL4^hs.PB

tkv^{Q199D.UAS.cTa}

visible, with Scer\GAL4^pnr-MD237

visible, with Scer\GAL4^ptc-559.1

visible, with Scer\GAL4^tsh-Gal4-1

tkv^{Q199D.UAS.cTa}

visible, with Scer\GAL4^unspecified

tkv^{Q199D.UAS.Tag:HA}

visible, with Scer\GAL4^vg.PM

visible (with Df(2L)tkv3)

tkv¹

visible (with tkv⁷)

tkv⁴²⁷

visible (with tkv⁴²⁷)

tkv⁷

visible | adult stage, with Scer\GAL4^nub.PU

tkv^UAS.cUa

visible | adult stage, with Scer\GAL4^pnr-MD237

tkv^DN.UAS.cUa

visible | adult stage, with Scer\GAL4^sd-SG29.1

tkv^RNAi.IR2.UAS

visible | adult stage | dominant

tkv⁷

visible | adult stage | dominant | somatic clone

tkv^C97R-mCherry

visible | adult stage | somatic clone, with Scer\GAL4^nub.PU

tkv^UAS.cUa

visible | cold sensitive

tkv¹

visible | dominant

visible | recessive

visible | somatic clone, with Scer\GAL4^Act5C.PP

tkv^{Q253D.UAS.cNc}

wild-type

Phenotype manifest in

Allele

abdomen, with Scer\GAL4^71B

tkv^CA.UAS

abdominal 1 ventral denticle belt | maternal effect

tkv⁴

abdominal 2 ventral denticle belt | maternal effect

tkv⁴

abdominal 3 ventral denticle belt | maternal effect

tkv⁴

abdominal 4 ventral denticle belt | maternal effect

tkv⁴

abdominal 5 ventral denticle belt | maternal effect

tkv⁴

abdominal 6 ventral denticle belt | maternal effect

tkv⁴

abdominal 7 ventral denticle belt | maternal effect

tkv⁴

adherens junction (with tkv^RNAi.IR1.UAS), with Scer\GAL4^GMR.PF

tkv^RNAi.IR2.UAS

adherens junction (with tkv^RNAi.IR2.UAS), with Scer\GAL4^GMR.PF

tkv^RNAi.IR1.UAS

adherens junction & embryonic dorsal trunk, with Scer\GAL4^btl.B123

tkv^{Q199D.UAS.Tag:HA}

adherens junction & embryonic dorsal trunk, with Scer\GAL4^btl.PS

tkv^{Q199D.UAS.Tag:HA}

adult brain | RU486 conditional, with Scer\GAL4^{elav.Switch.PO}

tkv^CA.UAS

adult gut | conditional, with Scer\GAL4^esg.PU

tkv^{Q253D.UAS.cNb}

adult gut | conditional, with Scer\GAL4^esg.PU, Scer\GAL80^Su(H).GBE

tkv^GD2549

adult head & cuticle | somatic clone

tkv⁸

adult midgut epithelium, with Scer\GAL4^esg.PU

tkv^GD2549

adult midgut progenitor cell | somatic clone

tkv⁸

adult optic lobe | somatic clone

tkv⁸

adult posterior midgut epithelium, with Scer\GAL4^GMR24H06

tkv^GD2549

adult posterior midgut epithelium | somatic clone

adult thorax

tkv^2L-223-29

adult thorax, with Scer\GAL4^LE

tkv^DN.UAS.cUa

adult thorax, with Scer\GAL4^pnr-MD237

tkv^DN.UAS.cUa

air sac primordium | third instar larval stage, with Scer\GAL4^btl.PS

tkv^1ΔGSK.UAS

amnioserosa

tkv⁸

analia, with Scer\GAL4^cad-em459

tkv^{Q253D.UAS.cNb}

anterior crossvein

tkv⁷

anterior crossvein, with Scer\GAL4^dpp.blk1

tkv^{Q253D.UAS.cNb}

anterior crossvein, with Scer\GAL4^nub-AC-62

tkv^{1AΔGS.UAS.Tag:HA}

anterior crossvein, with Scer\GAL4^ptc-559.1

tkv^1ΔGSK.UAS

anterior crossvein (with tkv⁷)

tkv⁴²⁷

anterior crossvein (with tkv⁴²⁷)

tkv⁷

anterior-posterior compartment boundary of the wing disc, with Scer\GAL4^dpp.blk1

tkv^{Q253D.UAS.cNb}

anterior wing margin, with Scer\GAL4^vg.int2.1

tkv^{Q253D.UAS.cNb}

apoptotic amnioserosa

tkv^{Q253D.UAS.cNb}

bouton (with tkv¹)

tkv⁸

bouton (with tkv⁷)

tkv^k16713

bouton (with tkv⁸)

tkv¹

bouton (with tkv^k16713)

tkv⁷

cell cycle | somatic clone, with Scer\GAL4^Act5C.PP

tkv^{Q253D.UAS.cNc}

cephalopharyngeal skeleton

tkv⁸

copper cell | heat sensitive, with Scer\GAL4^NP5130, Scer\GAL80^ts.αTub84B

tkv^GD2549

crossvein, with Scer\GAL4^A9

cystoblast, with Scer\GAL4^{VP16.nanos.UTR}

tkv^Q253D.UASp

cystoblast | ectopic | germline clone, with Scer\GAL4^{VP16.nanos.UTR}

tkv^ca.UASp

dense core granule | adult stage, with Scer\GAL4^NP0261

tkv^JF01485

discal wing cell, with Scer\GAL4^71B

tkv^UAS.cLa

dorsal appendage, with Scer\GAL4^CY2

dorsal mesothoracic disc & actin filament | somatic clone

tkv^xtr

dorsal mesothoracic disc & microtubule | apical | somatic clone

tkv^xtr

dorsal row of triple row of wing sensilla

tkv⁶

dorsal row of triple row of wing sensilla, with Scer\GAL4^A9

dorsal tracheal branch primordium, with Scer\GAL4^btl.PS

tkv^{Q253D.UAS.cLa}

egg chamber, with Scer\GAL4^hs.PB

tkv^Q199D.UAS

egg chamber, with Scer\GAL4^{VP16.nanos.UTR}

tkv^Q253D.UASp

egg operculum, with Scer\GAL4^CY2

embryo

embryo | dorsal closure stage

tkv⁷

embryo | embryonic stage 14

tkv⁸

embryo | maternal effect, with Scer\GAL4^{VP16.mat.αTub67C}

embryonic/first instar larval cuticle

embryonic/first instar larval cuticle, with Scer\GAL4^69B

embryonic/first instar larval cuticle | dorsal

tkv⁸

embryonic/larval crystal cell

tkv⁷

embryonic/larval dorsal tracheal branch

embryonic/larval dorsal tracheal branch 1 | embryonic stage

tkv⁸

embryonic/larval dorsal tracheal branch 2 | embryonic stage

tkv⁸

embryonic/larval dorsal tracheal branch 3 | embryonic stage

tkv⁸

embryonic/larval dorsal tracheal branch 4 | embryonic stage

tkv⁸

embryonic/larval dorsal tracheal branch 5 | embryonic stage

tkv⁸

embryonic/larval dorsal tracheal branch 6 | embryonic stage

tkv⁸

embryonic/larval dorsal tracheal branch 7 | embryonic stage

tkv⁸

embryonic/larval dorsal tracheal branch 8 | embryonic stage

tkv⁸

embryonic/larval dorsal tracheal branch 9 | embryonic stage

tkv⁸

embryonic/larval dorsal tracheal branch 10 | embryonic stage

tkv⁸

embryonic/larval dorsal tracheal branch, with Scer\GAL4^btl.PS

embryonic/larval dorsal tracheal branch, with Scer\GAL4^esg-p127

tkv^1ΔGSK.UAS

embryonic/larval dorsal vessel

tkv⁷

embryonic/larval ganglionic tracheal branch 0 | embryonic stage

tkv⁸

embryonic/larval ganglionic tracheal branch 1 | embryonic stage

tkv⁸

embryonic/larval ganglionic tracheal branch 2 | embryonic stage

tkv⁸

embryonic/larval ganglionic tracheal branch 3 | embryonic stage

tkv⁸

embryonic/larval ganglionic tracheal branch 4 | embryonic stage

tkv⁸

embryonic/larval ganglionic tracheal branch 5 | embryonic stage

tkv⁸

embryonic/larval ganglionic tracheal branch 6 | embryonic stage

tkv⁸

embryonic/larval ganglionic tracheal branch 7 | embryonic stage

tkv⁸

embryonic/larval ganglionic tracheal branch 8 | embryonic stage

tkv⁸

embryonic/larval ganglionic tracheal branch 9 | embryonic stage

tkv⁸

embryonic/larval midgut | embryonic stage 16, with Scer\GAL4^Mef2.PU

tkv^RNAi.UAS.cUa

embryonic/larval neuromuscular junction (with tkv⁷)

tkv^k16713

embryonic/larval neuromuscular junction (with tkv^k16713)

tkv⁷

embryonic/larval neuromuscular junction | somatic clone, with Scer\GAL4^elav.PH

tkv^{Q199D.UAS.Tag:HA}

embryonic/larval tracheal dorsal trunk, with Scer\GAL4^69B

tkv^{Q253D.UAS.cLa}

embryonic/larval tracheal dorsal trunk, with Scer\GAL4^btl.PS

embryonic/larval tracheal lateral trunk

tkv⁸

embryonic/larval tracheal lateral trunk, with Scer\GAL4^69B

tkv^{Q253D.UAS.cLa}

embryonic/larval tracheal lateral trunk | embryonic stage

tkv⁸

embryonic/larval tracheal section

embryonic/larval visceral tracheal branch, with Scer\GAL4^btl.PS

tkv^{Q253D.UAS.cLa}

embryonic abdominal segment 7

tkv^Sz-1

embryonic abdominal segment 8

tkv^Sz-1

embryonic cardioblast, with Scer\GAL4^how-24B

tkv^CA.UAS.cUa

embryonic dorsal epidermis

embryonic epidermis

embryonic epidermis, with Scer\GAL4^prd.RG1

tkv^{Q253D.UAS.cNb}

embryonic epidermis | dorsal

tkv⁷

embryonic head

embryonic midgut constriction 2

tkv⁸

embryonic myoblast, with Scer\GAL4^how-24B

tkv^CA.UAS.cUa

embryonic pericardial cell, with Scer\GAL4^how-24B

tkv^CA.UAS.cUa

enteroblast of posterior adult midgut epithelium | increased number, with Scer\GAL4^esg.PU

tkv^GD2549

enterocyte of posterior adult midgut epithelium, with Scer\GAL4^esg.PU

tkv^GD2549

epidermal cell | larval stage | somatic clone, with Scer\GAL4^FRT.Act5C

tkv^{Q253D.UAS.cNb}

eye

tkv^Q253D.GMR

eye, with Scer\GAL4^GMR.PF

eye, with Scer\GAL4^GMR.PF, Scer\GAL4^ey.PH

eye | somatic clone

tkv⁸

eye disc

tkv⁵

eye disc | somatic clone

tkv⁸

eye disc morphogenetic furrow

tkv⁴

eye disc morphogenetic furrow, with Scer\GAL4^dpp.blk1

tkv^DN.K.UAS

eye disc posterior compartment | somatic clone | third instar larval stage

tkv⁴

eye photoreceptor cell | somatic clone

tkv⁸

female germline cell, with Scer\GAL4^{VP16.nanos.UTR}

tkv^Q253D.UASp

female germline cell | increased number

tkv^S238A.ca.bam

female germline cell | increased number, with Scer\GAL4^{VP16.nanos.UTR}

tkv^ca.UASp

female germline stem cell

tkv⁸

female germline stem cell | ectopic, with Scer\GAL4^{VP16.nanos.UTR}

tkv^Q253D.UASp

female germline stem cell | increased number, with Scer\GAL4^nanos.PU

tkv^QD.UAS.cUa

female germline stem cell | increased number, with Scer\GAL4^{VP16.nanos.UTR}

female germline stem cell | somatic clone

tkv⁸

filamentous actin

tkv⁸

filzkorper

first posterior wing cell

tkv¹

gastric caecum

tkv⁸

genital disc primordium

tkv^unspecified

genitalia, with Scer\GAL4^cad-em459

tkv^{Q253D.UAS.cNb}

germarium

tkv^S238A.ca.bam

germarium, with Scer\GAL4^C587

germarium, with Scer\GAL4^{VP16.nanos.UTR}

germarium | germline clone, with Scer\GAL4^{VP16.nanos.UTR}

tkv^ca.UASp

germline cell

tkv⁸

germline cell, with Scer\GAL4^{VP16.nanos.UTR}

germline cell | male, with Scer\GAL4^{VP16.nanos.UTR}

tkv^{Q253D.UAS.cNb}

gonad, with Scer\GAL4^{VP16.nanos.UTR}

tkv^{Q253D.UAS.cLa}

gut epithelium | conditional, with Scer\GAL4^esg.PU, Scer\GAL80^Su(H).GBE

tkv^GD2549

haltere, with Scer\GAL4^Tub.PU, Scer\GAL4^vg.int2.1

tkv^RNAi.UAS

histoblast | somatic clone

tkv⁴

histoblast | somatic clone, with Scer\GAL4^FRT.Act5C

tkv^{Q253D.UAS.cNb}

histoblast nest | somatic clone

tkv⁴

histoblast nest | somatic clone, with Scer\GAL4^FRT.Act5C

tkv^{Q253D.UAS.cNb}

hub cell, with Scer\GAL4^{VP16.nanos.UTR}

tkv^{Q253D.UAS.cNb}

interommatidial precursor cell | pupal stage P6 (with tkv^RNAi.IR1.UAS), with Scer\GAL4^GMR.PF

tkv^RNAi.IR2.UAS

interommatidial precursor cell | pupal stage P6 (with tkv^RNAi.IR2.UAS), with Scer\GAL4^GMR.PF

tkv^RNAi.IR1.UAS

intestinal stem cell | somatic clone

intestinal stem cell | somatic clone, with Scer\GAL4^Tub.PU

tkv^ca.UASp

intestinal stem cell of posterior adult midgut epithelium | increased number, with Scer\GAL4^esg.PU

tkv^GD2549

larval muscle system, with Scer\GAL4^btl.PS

tkv^{Q253D.UAS.cLa}

larval tracheal system

tkv⁸

larval tracheal system, with Scer\GAL4^btl.PS

tkv^{Q253D.UAS.cNb}

late endosome | increased number, with Scer\GAL4^NP0261

tkv^{Q199D.UAS.Tag:HA}

leg

leg & adult cuticle | somatic clone

tkv^xtr

leg & sex comb | ectopic

tkv⁰⁴⁴¹⁵

leg disc

lysosome | adult stage, with Scer\GAL4^dsx.KI

lysosome | adult stage, with Scer\GAL4^NP0261

tkv^{Q199D.UAS.Tag:HA}

macrochaeta | ectopic, with Scer\GAL4^Act5C.PI

tkv^{Q199D.UAS.cTa}

macrochaeta | ectopic, with Scer\GAL4^hs.PB

tkv^{Q199D.UAS.cTa}

macrochaeta | ectopic, with Scer\GAL4^tsh-Gal4-1

tkv^{Q199D.UAS.cTa}

male accessory gland secondary cell, with Scer\GAL4^dsx.KI

male accessory gland secondary cell, with Scer\GAL4^esg.PU

male accessory gland secondary cell, with Scer\GAL4^NP0261

male germline stem cell | germline clone

tkv⁸

Malpighian tubule

tkv⁷

medial row of triple row of wing sensilla

tkv⁶

medial row of triple row of wing sensilla, with Scer\GAL4^A9

mesoderm, with Scer\GAL4^how-24B, Scer\GAL4^twi.PG

tkv^{Q253D.UAS.cNb}

mesonotum, with Scer\GAL4^pnr-MD237

mesothoracic tergotrochanter muscle cell | increased number, with Scer\GAL4¹¹⁵¹

tkv^CA.UAS

mesothoracic ventral denticle belt | maternal effect

tkv⁴

metathoracic ventral denticle belt | maternal effect

tkv⁴

mitotic domain 1 | embryonic stage 13

tkv⁸

mitotic domain 1 | embryonic stage 15

tkv⁸

multivesicular body, with Scer\GAL4^NP0261

tkv^{Q199D.UAS.Tag:HA}

multivesicular body | adult stage, with Scer\GAL4^dsx.KI

multivesicular body | adult stage, with Scer\GAL4^NP0261

tkv^{Q199D.UAS.Tag:HA}

neuromuscular junction, with Scer\GAL4^elav.PLu

tkv^{1AΔGS.UAS.Tag:HA}

neuromuscular junction, with Scer\GAL4^Mhc.PW

tkv^{Q199D.UAS.Tag:HA}

neuromuscular junction (with tkv¹)

neuromuscular junction (with tkv⁷)

neuromuscular junction (with tkv⁸)

tkv¹

neuromuscular junction (with tkv^k16713)

tkv⁷

NMJ bouton | increased number | third instar larval stage, with Scer\GAL4^elav-C155

tkv^CA.UAS

NMJ bouton | larval stage | increased number, with Scer\GAL4^elav-C155

tkv^{Q199D.UAS.Tag:HA}

NMJ bouton | somatic clone, with Scer\GAL4^elav.PH

tkv^{Q199D.UAS.Tag:HA}

NMJ bouton | third instar larval stage (with tkv⁸)

tkv^k16713

NMJ bouton | third instar larval stage (with tkv^k16713)

tkv⁸

nucleus | adult stage, with Scer\GAL4^dsx.KI

tkv^{Q199D.UAS.Tag:HA}

nucleus | adult stage, with Scer\GAL4^esg.PU

nucleus | adult stage, with Scer\GAL4^NP0261

tkv^{Q199D.UAS.Tag:HA}

ommatidium, with Scer\GAL4^GMR.PF

tkv^{Q253D.UAS.cNb}

ommatidium | cell non-autonomous | somatic clone

tkv⁸

ovary

tkv^S238A.ca.bam

ovary, with Scer\GAL4^{VP16.nanos.UTR}

pericardial cell, with Scer\GAL4^how-24B, Scer\GAL4^twi.PG

tkv^{Q253D.UAS.cNb}

peripodial epithelium | cell autonomous | somatic clone

tkv⁵

posterior crossvein, with Scer\GAL4^nub-AC-62

tkv^{1AΔGS.UAS.Tag:HA}

posterior crossvein (with tkv⁷)

tkv⁴²⁷

posterior crossvein (with tkv⁴²⁷)

tkv⁷

presumptive embryonic salivary gland

tkv⁴

prothoracic ventral denticle belt | maternal effect

tkv⁴

retina | pupal stage P6, with Scer\GAL4^GMR.PF, tkv^RNAi.IR1.UAS

tkv^RNAi.IR2.UAS

retina | pupal stage P6, with Scer\GAL4^GMR.PF, tkv^RNAi.IR2.UAS

tkv^RNAi.IR1.UAS

scutellar bristle | increased number, with Scer\GAL4^ptc-559.1

tkv^{1AΔGS.UAS.Tag:HA}

scutum

tkv^D17

scutum & macrochaeta, with Scer\GAL4^Act5C.PI

tkv^{Q199D.UAS.cTa}

scutum & macrochaeta, with Scer\GAL4^hs.PB

tkv^{Q199D.UAS.cTa}

scutum & macrochaeta, with Scer\GAL4^tsh-Gal4-1

tkv^{Q199D.UAS.cTa}

secondary pigment cell | pupal stage P7 | somatic clone

second posterior wing cell, with Scer\GAL4^71B

tkv^UAS.cLa

secretory vesicle | adult stage, with Scer\GAL4^dsx.KI

sensory mother cell & dorsal mesothoracic disc, with Scer\GAL4^hs.PB

tkv^{Q199D.UAS.cTa}

sensory mother cell & dorsal mesothoracic disc, with Scer\GAL4^tsh-Gal4-1

tkv^{Q199D.UAS.cTa}

sensory mother cell | ectopic, with Scer\GAL4^hs.PB

tkv^{Q199D.UAS.cTa}

sensory mother cell | ectopic, with Scer\GAL4^tsh-Gal4-1

tkv^{Q199D.UAS.cTa}

sex comb | ectopic

tkv⁰⁴⁴¹⁵

spectrosome

tkv⁸

spectrosome, with Scer\GAL4^{VP16.nanos.UTR}

tkv^JF01485

submarginal wing cell

tkv¹

submarginal wing cell, with Scer\GAL4^71B

tkv^UAS.cLa

synapse

tkv^unspecified

tarsal segment | dorsal

tkv⁸

tarsal segment | ventral

tkv⁸

t-bar

tkv^unspecified

telson | maternal effect

tkv⁴

testis

tkv^ca.bam

testis | germline clone

tkv⁴

testis | germline clone, with Scer\GAL4^Act5C.PI

tkv^{Q253D.UAS.cNb}

thoracic adult muscle precursor cell, with Scer\GAL4¹¹⁵¹

tkv^CA.UAS

tracheal dorsal trunk primordium, with Scer\GAL4^btl.PS

tkv^{Q199D.UAS.Tag:HA}

tracheal pit, with Scer\GAL4^btl.PS

tkv^{Q253D.UAS.cLa}

tracheal section

tkv⁸

tracheocyte, with Scer\GAL4^69B

tkv^{Q253D.UAS.cLa}

tracheocyte, with Scer\GAL4^btl.PS

tkv^{Q253D.UAS.cLa}

ventral denticle belt

ventral denticle belt, with Scer\GAL4^69B

tkv^{Q253D.UAS.cNb}

ventral row of triple row of wing sensilla

tkv⁶

ventral row of triple row of wing sensilla, with Scer\GAL4^A9

visceral mesoderm & parasegment 7

tkv⁸

visceral trunk mesoderm

tkv⁴

wing

wing, with Scer\GAL4^71B

tkv^CA.UAS

wing, with Scer\GAL4⁶⁰⁴

tkv^{Q253D.UAS.cLa}

wing, with Scer\GAL4^A9

wing, with Scer\GAL4^bs-1348

tkv^{Q253D.UAS.cLa}

wing, with Scer\GAL4^Bx-MS1096

wing, with Scer\GAL4^C-580

tkv^{Q253D.UAS.cLa}

wing, with Scer\GAL4^C-765

tkv^RNAi.UAS.cUa

wing, with Scer\GAL4^dpp.blk1

wing, with Scer\GAL4^nub.PU

tkv^UAS.cUa

wing, with Scer\GAL4^nub-AC-62

wing, with Scer\GAL4^ptc-559.1

wing, with Scer\GAL4^salm-459.2

tkv^{Q253D.UAS.cNb}

wing, with Scer\GAL4^Ser.PGF

tkv^{Q253D.UAS.cLa}

wing, with Scer\GAL4^T80

tkv^{Q199D.UAS.Tag:HA}

wing, with Scer\GAL4^Tub.PU

tkv^UAS.cNa

wing, with Scer\GAL4^Tub.PU, Scer\GAL4^vg.int2.1

wing, with Scer\GAL4^unspecified

tkv^{Q199D.UAS.Tag:HA}

wing, with Scer\GAL4^vg.PM

tkv^{Q253D.UAS.cNb}

wing (with tkv⁷)

tkv⁴²⁷

wing (with tkv⁴²⁷)

tkv⁷

wing & adult cuticle | somatic clone

tkv^xtr

wing | distal | somatic clone

tkv⁴

wing | medial | somatic clone

tkv⁴

wing | prepupal stage, with Scer\GAL4^ptc-559.1

tkv^UAS.cNa

wing | somatic clone, with Scer\GAL4^Act5C.PP

tkv^{Q253D.UAS.cNc}

wing | somatic clone, with Scer\GAL4^nub.PU

tkv^UAS.cUa

wing blade, with Scer\GAL4^Bx-MS1096

tkv^{1AΔGS.UAS.Tag:HA}

wing blade, with Scer\GAL4^dpp.blk1

tkv^{Q253D.UAS.cNb}

wing blade posterior compartment

tkv^UAS.cLa

wing cell

tkv^{Q199D.UAS.Tag:HA}

wing cell, with Scer\GAL4^A9

tkv^{Q199D.UAS.Tag:HA}

wing cell, with Scer\GAL4^e22c

tkv^{Q253D.UAS.cNb}

wing cell, with Scer\GAL4^hs.PB

tkv^{Q253D.UAS.cNb}

wing disc

tkv⁸

wing disc, with Scer\GAL4^69B

tkv^CA.UAS

wing disc, with Scer\GAL4^71B

tkv^CA.UAS

wing disc, with Scer\GAL4^A9

wing disc, with Scer\GAL4^Act5C.PI

tkv^CA.UAS

wing disc, with Scer\GAL4^C-765

wing disc, with Scer\GAL4^nub-AC-62

tkv^{Q253D.UAS.cNb}

wing disc, with Scer\GAL4^tsh-Gal4-1

tkv^{Q199D.UAS.cTa}

wing disc, with Scer\GAL4^Tub.PU

tkv^UAS.cNa

wing disc (with tkv⁷)

tkv⁴²⁷

wing disc (with tkv⁴²⁷)

tkv⁷

wing disc | cell non-autonomous | somatic clone | third instar larval stage, with Scer\GAL4^{Act5C.Switch.PR}

wing disc | larval stage

wing disc | somatic clone

wing disc | somatic clone, with Scer\GAL4^Act5C.PI

tkv^CA.UAS

wing disc | somatic clone, with Scer\GAL4^Act5C.PP

wing disc | somatic clone, with Scer\GAL4^FRT.Act5C

tkv^{Q253D.UAS.cNc}

wing disc | somatic clone, with Scer\GAL4^nub.PU

tkv^UAS.cUa

wing disc | somatic clone | third instar larval stage, with Scer\GAL4^{Act5C.Switch.PR}

wing disc | third instar larval stage, with Scer\GAL4^{Act5C.Switch.PR}

tkv^{Q253D.UAS.cNc}

wing disc | third instar larval stage, with Scer\GAL4^ap-md544

tkv^UAS.cNa

wing disc | third instar larval stage, with Scer\GAL4^en-e16E

tkv^HMS02185

wing margin | ectopic

tkv⁵

wing margin bristle, with Scer\GAL4^vg.int2.1

tkv^{Q253D.UAS.cNb}

wing pouch, with Scer\GAL4^dpp.blk1

tkv^{Q253D.UAS.cNb}

wing pouch, with Scer\GAL4^ptc-559.1

tkv^UAS.cNa

wing sensillum, with Scer\GAL4^Act5C.PI

tkv^UAS.cNa

wing vein

wing vein, with Scer\GAL4^71B

tkv^CA.UAS

wing vein, with Scer\GAL4^A9

tkv^{Q199D.UAS.Tag:HA}

wing vein, with Scer\GAL4^Act5C.PI

tkv^UAS.cNa

wing vein, with Scer\GAL4^Bx-MS1096

tkv^{1AΔGS.UAS.Tag:HA}

wing vein, with Scer\GAL4^e22c

tkv^{Q253D.UAS.cNb}

wing vein, with Scer\GAL4^hs.PB

tkv^{Q253D.UAS.cNb}

wing vein, with Scer\GAL4^nub-AC-62

tkv^{Q253D.UAS.cNb}

wing vein, with Scer\GAL4^salm-459.2

tkv^{Q253D.UAS.cNb}

wing vein (with Df(2L)tkv3)

tkv¹

wing vein | ectopic

wing vein | ectopic, with Scer\GAL4⁶⁰⁴

tkv^{Q253D.UAS.cLa}

wing vein | ectopic, with Scer\GAL4^A9

tkv^{Q199D.UAS.Tag:HA}

wing vein | ectopic, with Scer\GAL4^bs-1348

tkv^{Q253D.UAS.cLa}

wing vein | ectopic, with Scer\GAL4^C-580

tkv^{Q253D.UAS.cLa}

wing vein | ectopic, with Scer\GAL4^C-765

tkv^RNAi.UAS.cUa

wing vein | ectopic, with Scer\GAL4^sd-SG29.1

tkv^RNAi.IR2.UAS

wing vein | ectopic, with Scer\GAL4^vg.PM

tkv^RNAi.UAS.cUa

wing vein | ectopic | somatic clone

tkv^Q253D.Ubx

wing vein | ectopic | somatic clone, with Scer\GAL4^Act5C.PP

tkv^{Q253D.UAS.cNc}

wing vein | somatic clone, with Scer\GAL4^Act5C.PP

tkv^{Q253D.UAS.cNc}

wing vein L2

wing vein L2, with Scer\GAL4^A9

wing vein L2 | distal, with Scer\GAL4^sd-SG29.1

tkv^RNAi.IR2.UAS

wing vein L3

tkv⁷

wing vein L3, with Scer\GAL4^A9

wing vein L3, with Scer\GAL4^nub-AC-62

tkv^{1AΔGS.UAS.Tag:HA}

wing vein L3, with Scer\GAL4^ptc-559.1

tkv^{1AΔGS.UAS.Tag:HA}

wing vein L4

tkv⁷

wing vein L4, with Scer\GAL4^A9

wing vein L4, with Scer\GAL4^ap-md544

tkv^{1AΔGS.UAS.Tag:HA}

wing vein L4, with Scer\GAL4^dpp.blk1

tkv^UAS.cNa

wing vein L4, with Scer\GAL4^en-e16E

tkv^UAS.Tag:HA

wing vein L4, with Scer\GAL4^nub-AC-62

tkv^{1AΔGS.UAS.Tag:HA}

wing vein L4, with Scer\GAL4^ptc-559.1

wing vein L4 (with tkv⁷)

tkv⁴²⁷

wing vein L4 (with tkv⁴²⁷)

tkv⁷

wing vein L4 | distal

wing vein L5, with Scer\GAL4^A9

wing vein L5, with Scer\GAL4^dpp.blk1

tkv^UAS.cNa

wing vein L5, with Scer\GAL4^en-e16E

tkv^UAS.Tag:HA

wing vein L5, with Scer\GAL4^vg.int2.1

tkv^{Q253D.UAS.cNb}

wing vein L5 | distal, with Scer\GAL4^sd-SG29.1

tkv^RNAi.IR2.UAS

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (38)

Hsap\BMPR1B

11 of 14

Yes

Hsap\BMPR1A

8 of 14

Yes

7 of 14

7 of 14

6 of 14

6 of 14

6 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (22)

Rnor\Bmpr1b

11 of 14

Yes

Rnor\Bmpr1a

9 of 14

Yes

7 of 14

7 of 14

6 of 14

5 of 14

5 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Map3k7

1 of 14

Rnor\Mertk

1 of 14

Yes

Rnor\Mos

1 of 14

Rnor\Ripk1

1 of 14

Rnor\Tgfbr2

1 of 14

Mus musculus (laboratory mouse) (20)

Mmus\Bmpr1b

12 of 14

Yes

Mmus\Bmpr1a

9 of 14

Yes

7 of 14

7 of 14

6 of 14

6 of 14

5 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Mos

1 of 14

Mmus\Ripk1

1 of 14

Mmus\Tgfbr2

1 of 14

Xenopus tropicalis (Western clawed frog) (24)

Xtro\bmpr1a

7 of 13

Yes

Xtro\bmpr1b

7 of 13

Yes

5 of 13

4 of 13

3 of 13

3 of 13

3 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\swsap1

1 of 13

Yes

Xtro\tgfbr2l

1 of 13

Xtro\tgfbr2

1 of 13

Danio rerio (Zebrafish) (31)

Drer\bmpr1aa

10 of 14

Yes

Drer\bmpr1ba

10 of 14

Yes

Drer\bmpr1bb

9 of 14

Yes

Drer\bmpr1ab

8 of 14

Yes

7 of 14

7 of 14

7 of 14

6 of 14

6 of 14

6 of 14

5 of 14

2 of 14

2 of 14

1 of 14

Yes

Drer\aatkb

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (43)

Cele\sma-6

14 of 14

Yes

4 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (22)

Agam\AgaP_AGAP009329

11 of 12

Yes

5 of 12

5 of 12

5 of 12

3 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (122)

Atha\APK2A

1 of 13

Yes

Atha\AT1G06840

1 of 13

Yes

Atha\AT1G11300

1 of 13

Yes

Atha\AT1G11330

1 of 13

Yes

Atha\AT1G16270

1 of 13

Yes

Atha\AT1G16670

1 of 13

Yes

Atha\AT1G18160

1 of 13

Yes

Atha\AT1G24030

1 of 13

Yes

Atha\AT1G49730

1 of 13

Yes

Atha\AT1G51830

1 of 13

Yes

Atha\AT1G61360

1 of 13

Yes

Atha\AT1G61370

1 of 13

Yes

Atha\AT1G61400

1 of 13

Yes

Atha\AT1G61440

1 of 13

Yes

Atha\AT1G61610

1 of 13

Yes

Atha\AT1G66910

1 of 13

Yes

Atha\AT1G67000

1 of 13

Yes

Atha\AT1G67890

1 of 13

Yes

Atha\AT1G73660

1 of 13

Yes

Atha\AT1G79570

1 of 13

Yes

Atha\AT2G14440

1 of 13

Yes

Atha\AT2G14510

1 of 13

Yes

Atha\AT2G19210

1 of 13

Yes

Atha\AT2G19230

1 of 13

Yes

Atha\AT2G24360

1 of 13

Yes

Atha\AT2G29220

1 of 13

Yes

Atha\AT2G31010

1 of 13

Yes

Atha\AT2G31800

1 of 13

Yes

Atha\AT2G40860

1 of 13

Yes

Atha\AT2G43850

1 of 13

Yes

Atha\AT3G01490

1 of 13

Yes

Atha\AT3G06620

1 of 13

Yes

Atha\AT3G06630

1 of 13

Yes

Atha\AT3G06640

1 of 13

Yes

Atha\AT3G20200

1 of 13

Yes

Atha\AT3G22750

1 of 13

Yes

Atha\AT3G46920

1 of 13

Yes

Atha\AT3G46930

1 of 13

Yes

Atha\AT3G50720

1 of 13

Yes

Atha\AT3G50730

1 of 13

Yes

Atha\AT3G53590

1 of 13

Yes

Atha\AT3G53810

1 of 13

Yes

Atha\AT3G55550

1 of 13

Yes

Atha\AT3G58640

1 of 13

Yes

Atha\AT3G59740

1 of 13

Yes

Atha\AT3G59830

1 of 13

Yes

Atha\AT4G08850

1 of 13

Yes

Atha\AT4G14780

1 of 13

Yes

Atha\AT4G18250

1 of 13

Yes

Atha\AT4G23050

1 of 13

Yes

Atha\AT4G24480

1 of 13

Yes

Atha\AT4G28350

1 of 13

Yes

Atha\AT4G29990

1 of 13

Yes

Atha\AT4G31170

1 of 13

Yes

Atha\AT5G06740

1 of 13

Yes

Atha\AT5G10530

1 of 13

Yes

Atha\AT5G11850

1 of 13

Yes

Atha\AT5G18910

1 of 13

Yes

Atha\AT5G25930

1 of 13

Yes

Atha\AT5G38250

1 of 13

Yes

Atha\AT5G42440

1 of 13

Yes

Atha\AT5G47070

1 of 13

Yes

Atha\AT5G48740

1 of 13

Yes

Atha\AT5G50000

1 of 13

Yes

Atha\AT5G50180

1 of 13

Yes

Atha\AT5G57610

1 of 13

Yes

Atha\AT5G58950

1 of 13

Yes

Atha\AT5G59260

1 of 13

Yes

Atha\AT5G59270

1 of 13

Yes

Atha\AT5G65600

1 of 13

Yes

Atha\AT5G66710

1 of 13

Yes

Atha\ATMRK1

1 of 13

Yes

Atha\BRL1

1 of 13

Yes

Atha\BRL3

1 of 13

Yes

Atha\CCR4

1 of 13

Yes

Atha\CDKE;1

1 of 13

Yes

Atha\CERK1

1 of 13

Yes

Atha\CLV1

1 of 13

Yes

Atha\CRK3

1 of 13

Yes

Atha\CRK6

1 of 13

Yes

Atha\CRK7

1 of 13

Yes

Atha\CRK8

1 of 13

Yes

Atha\CRK11

1 of 13

Yes

Atha\CRK14

1 of 13

Yes

Atha\CRK15

1 of 13

Yes

Atha\CRK16

1 of 13

Yes

Atha\CRK19

1 of 13

Yes

Atha\CRK24

1 of 13

Yes

Atha\CRK25

1 of 13

Yes

Atha\CRK27

1 of 13

Yes

Atha\CRK36

1 of 13

Yes

Atha\CRK37

1 of 13

Yes

Atha\CRK38

1 of 13

Yes

Atha\CRK39

1 of 13

Yes

Atha\CRK40

1 of 13

Yes

Atha\CRK41

1 of 13

Yes

Atha\CRK42

1 of 13

Yes

Atha\CRLK1

1 of 13

Yes

Atha\CTR1

1 of 13

Yes

Atha\EDR1

1 of 13

Yes

Atha\GSO2

1 of 13

Yes

Atha\HLECRK

1 of 13

Yes

Atha\HT1

1 of 13

Yes

Atha\IMK2

1 of 13

Yes

Atha\LECRKA4.2

1 of 13

Yes

Atha\LecRK-I.9

1 of 13

Yes

Atha\MEE39

1 of 13

Yes

Atha\NAK

1 of 13

Yes

Atha\PERK4

1 of 13

Yes

Atha\RBK2

1 of 13

Yes

Atha\RK2

1 of 13

Yes

Atha\RKF2

1 of 13

Yes

Atha\SD1-13

1 of 13

Yes

Atha\STY8

1 of 13

Yes

Atha\STY17

1 of 13

Yes

Atha\STY46

1 of 13

Yes

Atha\VIK

1 of 13

Yes

Atha\WAK1

1 of 13

Yes

Atha\WAK2

1 of 13

Yes

Atha\WAK3

1 of 13

Yes

Atha\WAK4

1 of 13

Yes

Atha\WAK5

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\PKH2

1 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:tkv. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (21)

sax

10 of 13

babo

9 of 13

put

3 of 13

wit

3 of 13

Alk

1 of 13

Btk

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Csk

1 of 13

Gucy2d

1 of 13

Gyc32E

1 of 13

Gyc76C

1 of 13

InR

1 of 13

Raf

1 of 13

Tak1

1 of 13

Takl1

1 of 13

Takl2

1 of 13

wnd

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

juvenile polyposis syndrome, TGF-β/BMP signaling pathway

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 7 )

Allele

Disease

Evidence

References

tkv⁴

CEA

(Guo et al., 2013)

tkv⁸

CEA

(Guo et al., 2013)

tkv^C40Y-mCherry

CEA

(Akiyama et al., 2018)

tkv^C90R-mCherry

CEA

(Akiyama et al., 2018)

tkv^C97R-mCherry

CEA

(Akiyama et al., 2018)

tkv^{R409C-mCherry}

DOES NOT model juvenile polyposis syndrome

CEA

(Akiyama et al., 2018)

tkv^{M442T-mCherry}

BMPR1B; bone morphogenetic protein receptor type 1B

CEA

(Akiyama et al., 2018)

Potential Models Based on Orthology ( 5 )

Human Ortholog

Disease

Evidence

References

model of brachydactyly type A1D

IEA

(FlyBase, 2019-)

model of acromesomelic dysplasia-3

IEA

(FlyBase, 2019-)

model of brachydactyly type A2

IEA

(FlyBase, 2019-)

BMPR1A; bone morphogenetic protein receptor type 1A

model of hereditary mixed polyposis syndrome 2

IEA

(FlyBase, 2019-)

BMPR1B; bone morphogenetic protein receptor type 1B

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 4 )

Allele

Disease

Interaction

References

tkv^JF01486

exacerbates Alzheimer's disease

modeled by Psn^RNAi.UAS.3

(Kang et al., 2024)

tkv⁸

ameliorates Angelman syndrome

modeled by Ube3a³⁵

(Li et al., 2016)

tkv^DN.UAS.cUa

ameliorates intestinal cancer

modeled by Apc2^N175K, Apc^Q8, Ras85D^V12.UAS

(Martorell et al., 2014)

tkv^k16713

ameliorates Angelman syndrome

modeled by Ube3a³⁵

(Li et al., 2016)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

11 of 14

603248

BMPR1A; bone morphogenetic protein receptor type 1A

8 of 14

601299

ACVR1B; activin A receptor type 1B

7 of 14

601300

PANCREATIC CANCER

pancreatic carcinoma

ACVR1C; activin A receptor type 1C

7 of 14

608981

ACVR1; activin A receptor type 1

6 of 14

102576

FIBRODYSPLASIA OSSIFICANS PROGRESSIVA; FOP

fibrodysplasia ossificans progressiva

ACVRL1; activin A receptor like type 1

6 of 14

601284

TELANGIECTASIA, HEREDITARY HEMORRHAGIC, TYPE 2; HHT2

hereditary hemorrhagic telangiectasia

TGFBR1; transforming growth factor beta receptor 1

6 of 14

190181

Loeys-Dietz syndrome 1

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Show neighbor-neighbor interactions:

Off

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

Select Layout:

Force Directed

Circle

Concentric

Legend:

Protein

RNA

Selected Interactor(s)

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

RNA-RNA

Physical Interaction

Assay

References

tkv - mir-124

luminiscence technology

(Sun et al., 2012)

RNA-protein

Physical Interaction

Assay

References

tkv - aub

iclip, partial RNA sequence identification

(Ma et al., 2017)

protein-protein

Physical Interaction

Assay

References

anti tag coimmunoprecipitation, anti tag western blot

(Haerry, 2010)

tkv - CG3164

(Guruharsha et al., 2011)

tkv - CG7668

anti tag coimmunoprecipitation, anti tag western blot, protein cross-linking with a bifunctional reagent, autoradiography, western blot, proximity ligation assay, fluorescence microscopy

(Guruharsha et al., 2011)

tkv - Dad

(Liu et al., 2023, Sharifkhodaei and Auld, 2021, Li et al., 2017, Kamiya et al., 2008, Inoue et al., 1998)

tkv - IntS11

anti tag coimmunoprecipitation, western blot

(Liu et al., 2023)

tkv - IntS8

anti tag coimmunoprecipitation, western blot, anti tag western blot

(Liu et al., 2023)

tkv - IntS9

anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, anti tag western blot, coimmunoprecipitation

(Liu et al., 2023)

tkv - Khc

(Guruharsha et al., 2011)

tkv - Klc

anti tag coimmunoprecipitation, anti tag western blot, protein cross-linking with a bifunctional reagent, autoradiography

(Guruharsha et al., 2011)

tkv - Mad

(Gui et al., 2016, Kaneko et al., 2011, Inoue et al., 1998)

tkv - Nlg4

anti tag coimmunoprecipitation, western blot, pull down, anti bait coimmunoprecipitation, anti tag western blot

(Zhang et al., 2017)

tkv - Rab5

anti tag coimmunoprecipitation, anti tag western blot

(Gui et al., 2016)

tkv - S6KL

anti tag coimmunoprecipitation, anti tag western blot

(Li et al., 2016, Zhao et al., 2015)

tkv - Smurf

anti tag coimmunoprecipitation, anti tag western blot, anti bait coimmunoprecipitation, western blot, enzymatic study

(Liu et al., 2023, Xia et al., 2010)

tkv - Ube3a

anti tag coimmunoprecipitation, western blot, anti tag western blot, enzymatic study

(Li et al., 2016)

tkv - babo

anti tag coimmunoprecipitation, anti tag western blot

(Haerry, 2010)

tkv - cv-2

anti tag coimmunoprecipitation, anti tag western blot

(Serpe et al., 2008)

tkv - dind

anti tag coimmunoprecipitation, western blot

(Zhao et al., 2022)

tkv - dpp

protein cross-linking with a bifunctional reagent, autoradiography, anti tag coimmunoprecipitation, anti tag western blot

(Le and Wharton, 2012, Haerry, 2010, Penton et al., 1994)

tkv - dx

anti tag coimmunoprecipitation, anti tag western blot

(Sharma et al., 2022)

tkv - fu

anti tag coimmunoprecipitation, peptide massfingerprinting, anti tag western blot

(Xia et al., 2010)

tkv - gbb

anti tag coimmunoprecipitation, anti tag western blot

(Haerry, 2010)

tkv - mew

anti bait coimmunoprecipitation, anti tag western blot

(Sawala et al., 2015)

tkv - mys

anti tag coimmunoprecipitation, anti tag western blot

(Sawala et al., 2015)

tkv - nwk

two hybrid, pull down, western blot

(O'Connor-Giles et al., 2008)

tkv - omd

anti tag coimmunoprecipitation, anti tag western blot

(Liu et al., 2023)

tkv - osk

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Hurd et al., 2016)

tkv - put

anti tag coimmunoprecipitation, autoradiography, anti tag western blot

(Haerry, 2010, Letsou et al., 1995)

tkv - sax

experimental knowledge based, anti tag coimmunoprecipitation, anti tag western blot

(Guruharsha et al., 2011, Haerry, 2010)

tkv - scb

anti tag coimmunoprecipitation, anti tag western blot

(Sawala et al., 2015)

tkv - scrib

anti tag coimmunoprecipitation, anti tag western blot

(Gui et al., 2016)

Summary of Genetic Interactions

esyN Network Diagram

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

esyN Network Key:

Suppression

Enhancement

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

Ack

(Zahedi et al., 2008)

suppressible

bam

(Casanueva and Ferguson, 2004)

suppressible

brk

(Martin et al., 2004, Torres-Vazquez et al., 2001)

suppressible

brm

(Marenda et al., 2004)

tkv|vvl

suppressible

btl

(Llimargas and Casanova, 1997)

suppressible

(Rodriguez, 2011)

suppressible

(Ricos et al., 1999)

enhanceable

(Yu et al., 2013)

enhanceable

(Bharathi et al., 2004)

suppressible

Dad

(Tsuneizumi et al., 1997)

suppressible

Dap160

(O'Connor-Giles et al., 2008)

enhanceable

dpp

(Crickmore and Mann, 2006, Penton et al., 1994)

suppressible

(de Celis, 1997)

suppressible

(de Celis, 1997)

suppressible

(Yan et al., 2009, Diaz-Benjumea and Garcia-Bellido, 1990)

suppressible

(Xia et al., 2010)

suppressible

(Xia et al., 2010)

enhanceable

(Khalsa et al., 1998)

suppressible

(Bach et al., 2003)

enhanceable

hep

(Adachi-Yamada et al., 1999)

suppressible

hep

(Adachi-Yamada et al., 1999)

puc|tkv

suppressible

hep

(Adachi-Yamada et al., 1999)

enhanceable

kek5

(Evans et al., 2009)

suppressible

kek5

(Evans et al., 2009)

suppressible

lili

(Dolezal et al., 2015)

suppressible

Lis-1

(Chen et al., 2010)

suppressible

Lpt

(Chauhan et al., 2013)

enhanceable

Lpt

(Chauhan et al., 2013)

brk|yki|tkv

enhanceable

Mad

(Oh and Irvine, 2011)

suppressible

Mad

(Das et al., 1998, Hoodless et al., 1996, Wiersdorff et al., 1996)

suppressible

Med

(Das et al., 1998)

enhanceable

(Steneberg et al., 1999, de Celis, 1997)

suppressible

(de Celis, 1997)

suppressible

nmo

(Zeng et al., 2007)

enhanceable

nmo

(Zeng et al., 2007)

suppressible

nwk

(O'Connor-Giles et al., 2008)

suppressible

Ote

(Jiang et al., 2008)

suppressible

p38b

(Adachi-Yamada et al., 1999)

enhanceable

pad

(Gibert et al., 2005)

suppressible

Pi3K21B

(Martin-Castellanos and Edgar, 2002)

suppressible

(Lu et al., 2022)

enhanceable

(Adachi-Yamada et al., 1999)

enhanceable

put

(Chen et al., 1998)

enhanceable

pyd

(Seppa et al., 2008)

suppressible

(de Celis, 1997)

suppressible

(Sekar et al., 2023, Martin-Castellanos and Edgar, 2002)

enhanceable

Rho1

(Cordero et al., 2007)

suppressible

(de Celis, 1997)

enhanceable

(Haerry, 2010)

enhanceable

(Cordero et al., 2007)

suppressible

shn

(Hoodless et al., 1996)

enhanceable

shn

(Staehling-Hampton et al., 1995)

suppressible

Snoo

(Barrio et al., 2007, Ramel et al., 2007, Takaesu et al., 2006)

enhanceable

Snr1

(Marenda et al., 2004)

suppressible

(Kim et al., 2006)

suppressible

(Ball et al., 2010)

suppressible

(Martin-Castellanos and Edgar, 2002)

Mad|tkv

enhanceable

(Oh and Irvine, 2011)

suppressible

(Oh and Irvine, 2011)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Liu et al., 2014)

suppressible

(Zhang et al., 2024)

anchor

suppressible

(Wang et al., 2018)

arm

suppressible

(Llimargas, 2000, McEwen et al., 2000)

suppressible

(Cai et al., 2019)

enhanceable

(Bartoszewski et al., 2004)

suppressible

(Ma et al., 2019)

suppressible

(Oh and Irvine, 2011)

brk

suppressible

(Torres-Vazquez et al., 2001)

btl

suppressible

(Myat et al., 2005)

enhanceable

(Yu et al., 2013)

suppressible

(Wang et al., 2024)

Cka

suppressible

(Chen et al., 2002)

csw

suppressible

(Oishi et al., 2006)

suppressible

(Liu et al., 2011)

suppressible

(Ayyub et al., 2015)

CycE

suppressible

tkv|dpp

(Horsfield et al., 1998)

Dad

suppressible

(Ogiso et al., 2011)

dally

suppressible

(Guo and Wang, 2009)

dpp

suppressible

(Bangi and Wharton, 2006, Haerry et al., 1998, Nguyen et al., 1998)

dpp

enhanceable

(Crickmore and Mann, 2006, de Celis, 1997)

dpp|lolal

suppressible

(Quijano et al., 2016)

dsh

suppressible

(Kirilly et al., 2005)

Egfr

suppressible

(Diaz-Benjumea and Garcia-Bellido, 1990)

enhanceable

(Niwa et al., 2004)

enhanceable

(Xia et al., 2010)

gbb

suppressible

(Bangi and Wharton, 2006, Haerry et al., 1998)

gbb

enhanceable

(Bangi and Wharton, 2006, Chen et al., 1998)

Gli

suppressible

(Sharifkhodaei et al., 2016)

Gli

enhanceable

(Sharifkhodaei et al., 2016)

suppressible

(Müller et al., 2005)

suppressible

(Gore et al., 2021)

hiw

enhanceable

(McCabe et al., 2004)

Impβ11

suppressible

(Higashi-Kovtun et al., 2010)

Irk2

enhanceable

(Dahal et al., 2012)

suppressible

(Hou et al., 1997)

suppressible

(Schneider et al., 2013)

Lis-1

suppressible

(Chen et al., 2010)

magu

suppressible

(Zheng et al., 2011, Vuilleumier et al., 2010)

mir-958

suppressible

(Mukherjee et al., 2021)

Mov10

enhanceable

(Takemura et al., 2021)

suppressible

(Su et al., 1998)

suppressible

(Saad and Hipfner, 2021)

Myc

suppressible

(Moreno and Basler, 2004)

myd

suppressible

(Sidisky et al., 2021)

enhanceable

(Steneberg et al., 1999)

nanos

suppressible

(Gilboa and Lehmann, 2004)

Nlg4

suppressible

(Zhang et al., 2017)

nmo

suppressible

(Merino et al., 2009)

nord

enhanceable

(Akiyama et al., 2022)

nwk

enhanceable

(Khuong et al., 2010, O'Connor-Giles et al., 2008)

pad

enhanceable

(Gibert et al., 2005)

peb

suppressible

(Wilk et al., 2004)

Pi3K21B

suppressible

(Martin-Castellanos and Edgar, 2002)

Pngl

suppressible

(Galeone et al., 2017)

put

enhanceable

(Bennett et al., 2003)

put|I-2

suppressible

(Bennett et al., 2003)

pyd

enhanceable

(Seppa et al., 2008)

Rab8

suppressible

(West et al., 2015)

Rac1

suppressible

(Ricos et al., 1999)

enhanceable

(de Celis, 1997)

suppressible

(Yang and Su, 2011)

enhanceable

(de Celis, 1997)

suppressible

(Zhao et al., 2015)

sax

suppressible

(Brummel et al., 1994)

scw

suppressible

(Nguyen et al., 1998)

Set1

suppressible

(Vidaurre et al., 2024)

suppressible

(Ma et al., 2019)

enhanceable

(Cordero et al., 2007)

smo

enhanceable

(Fu and Baker, 2003)

Snx16

enhanceable

(Rodal et al., 2011)

sog

suppressible

(Araujo et al., 2003)

sog

enhanceable

(Araujo et al., 2003)

spict

suppressible

(Wang et al., 2007)

spin

suppressible

(Yuva-Aydemir et al., 2011, Sweeney and Davis, 2002)

spin

suppressible

sax|tkv

(Yuva-Aydemir et al., 2011)

suppressible

(Liu et al., 2010)

suppressible

(Kim et al., 2006)

suppressible

(Li and Li, 2003)

suppressible

(Li et al., 2016)

suppressible

(Crickmore and Mann, 2006, de Navas et al., 2006)

upd1

suppressible

(Bach et al., 2003)

Vap33

suppressible

(Ratnaparkhi et al., 2008)

wit

suppressible

sax|tkv

(Veverytsa and Allan, 2011)

enhanceable

tkv|Mad

(Oh and Irvine, 2011)

enhanceable