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General Information
Symbol
Dmel\Tm1
Species
D. melanogaster
Name
Tropomyosin 1
Annotation Symbol
CG4898
Feature Type
FlyBase ID
FBgn0003721
Gene Model Status
Stock Availability
Gene Snapshot
In progress.Contributions welcome.
Also Known As
TmII, tropomyosin, tropomyosin II, cTm, Tm
Key Links
Genomic Location
Cytogenetic map
Sequence location
3R:15,281,371..15,308,779 [+]
Recombination map
3-56
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Protein Family (UniProt)
Belongs to the tropomyosin family. (P06754P49455)
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Summaries
Protein Function (UniProtKB)
Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction.
(UniProt, P06754P49455)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
Tm1: Tropomyosin 1 (J.C. Hall)
Structural gene for tropomyosin, a 34,000-dalton protein that acts as a regulator of motility in muscle and nonmuscle cells. At least five tropomyosin isoforms are encoded by Tm1, some in embryos (during myogenesis) and myogenic cell culture and others in the myofibrils of adult indirect flight muscles and leg muscles.
Gene Model and Products
Number of Transcripts
17
Number of Unique Polypeptides
13

Please see the GBrowse view of Dmel\Tm1 or the JBrowse view of Dmel\Tm1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.46
Gene model reviewed during 5.55
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0089960
2003
252
FBtr0089962
2651
441
FBtr0089965
2531
711
FBtr0089959
1684
501
FBtr0089964
2485
285
FBtr0089963
3054
678
FBtr0089961
2501
441
FBtr0089967
1248
285
FBtr0089957
1665
518
FBtr0089968
2194
284
FBtr0301959
1253
285
FBtr0301960
1253
285
FBtr0305654
1503
285
FBtr0305655
752
161
FBtr0305656
1318
250
FBtr0333917
1861
250
FBtr0333918
1253
285
Additional Transcript Data and Comments
Reported size (kB)
1.253 (longest cDNA)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0088899
29.3
252
4.47
FBpp0088901
48.0
441
5.15
FBpp0088904
80.1
711
5.09
FBpp0088898
53.4
501
4.05
FBpp0088903
32.7
285
4.38
FBpp0088902
74.7
678
9.49
FBpp0088900
48.0
441
5.15
FBpp0088906
32.7
285
4.38
FBpp0088896
54.6
518
4.08
FBpp0089024
32.5
284
4.43
FBpp0291171
32.7
285
4.38
FBpp0291172
32.8
285
4.40
FBpp0296934
32.7
285
4.38
FBpp0296935
18.4
161
5.02
FBpp0296936
29.2
250
4.54
FBpp0306045
29.1
250
4.54
FBpp0306046
32.7
285
4.40
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

285 aa isoforms: Tm1-PG, Tm1-PJ, Tm1-PM, Tm1-PO
441 aa isoforms: Tm1-PC, Tm1-PI
Additional Polypeptide Data and Comments
Reported size (kDa)
518, 504, 285, 252 (aa)
Comments
External Data
Subunit Structure (UniProtKB)
Homodimer (Probable). May interact with Unc-89 (via protein kinase domain 2) (PubMed:26251439).
(UniProt, P06754)
Homodimer.
(UniProt, P49455)
Domain
The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.
(UniProt, P06754, P49455)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Tm1 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (21 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
inferred from direct assay
inferred from physical interaction with UniProtKB:A8DYP0
(assigned by UniProt )
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
traceable author statement
inferred from biological aspect of ancestor with PANTHER:PTN000443979
(assigned by GO_Central )
Biological Process (9 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (6 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000443979
(assigned by GO_Central )
traceable author statement
non-traceable author statement
traceable author statement
non-traceable author statement
Cellular Component (8 terms)
Terms Based on Experimental Evidence (7 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from high throughput direct assay
inferred from direct assay
inferred from direct assay
inferred from direct assay
colocalizes_with sarcoplasmic reticulum
inferred from direct assay
colocalizes_with stress fiber
inferred from mutant phenotype
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000443979
(assigned by GO_Central )
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
expression microarray
Stage
Tissue/Position (including subcellular localization)
Reference
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
organism

Comment: maternally deposited

northern blot
Stage
Tissue/Position (including subcellular localization)
Reference

Comment: reference states 0-6 hr AEL

Comment: reference states >3-6 hr AEL

Additional Descriptive Data
Tm1 expression at embryonic stages 1-4 is localized to the posterior pole of the embryo.
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Evidence
References
inferred from mutant phenotype
inferred from high throughput direct assay
inferred from direct assay
inferred from direct assay
inferred from direct assay
colocalizes_with sarcoplasmic reticulum
inferred from direct assay
colocalizes_with stress fiber
inferred from mutant phenotype
Expression Deduced from Reporters
Reporter: P{-22-1367HSP}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{-22PI}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{-243PI}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{-1200LACcTm-3'}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{-1400PI}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{-1400PIΔ1.2}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{-1400PIΔBglII}
Stage
Tissue/Position (including subcellular localization)
Reference
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{+167-621HSP}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{+167-1367HSP}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{GAL4}2-35
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{GawB}Tm1C817
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{GawB}Tm1NP3018
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{PTT-GC}Tm1G5
Stage
Tissue/Position (including subcellular localization)
Reference
Stage
Tissue/Position (including subcellular localization)
Reference
Stage
Tissue/Position (including subcellular localization)
Reference
Stage
Tissue/Position (including subcellular localization)
Reference
Stage
Tissue/Position (including subcellular localization)
Reference
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Tm1 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 60 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 21 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Tm1
Transgenic constructs containing regulatory region of Tm1
Deletions and Duplications ( 4 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
dendritic arborising neuron & dendrite
dendritic arborising neuron & dendrite (with Tm1el4)
dendritic arborising neuron & dendrite (with Tm1S130510)
dorsal multidendritic neuron ddaC & dendrite | somatic clone
dorsal multidendritic neuron ddaE & dendrite
dorsal multidendritic neuron ddaE & dendrite (with Tm102299)
dorsal multidendritic neuron ddaE & dendrite (with Tm1el4)
dorsal multidendritic neuron ddaE & dendrite (with Tm1S130510)
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (6)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
12 of 15
Yes
Yes
10 of 15
No
Yes
10 of 15
No
Yes
 
9 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (5)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
10 of 15
Yes
Yes
10 of 15
Yes
Yes
9 of 15
No
Yes
9 of 15
No
Yes
1 of 15
No
No
Rattus norvegicus (Norway rat) (5)
10 of 13
Yes
Yes
9 of 13
No
Yes
9 of 13
No
Yes
7 of 13
No
No
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (4)
8 of 12
Yes
Yes
7 of 12
No
Yes
5 of 12
No
No
1 of 12
No
Yes
Danio rerio (Zebrafish) (6)
11 of 15
Yes
Yes
11 of 15
Yes
Yes
11 of 15
Yes
Yes
9 of 15
No
Yes
8 of 15
No
Yes
7 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (1)
13 of 15
Yes
Yes
Arabidopsis thaliana (thale-cress) (1)
1 of 9
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (2)
3 of 15
Yes
No
2 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (1)
2 of 12
Yes
No
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091907HJ )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Drosophila suzukii
Spotted wing Drosophila
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091506QW )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Mayetiola destructor
Hessian fly
Mayetiola destructor
Hessian fly
Anopheles darlingi
American malaria mosquito
Anopheles gambiae
Malaria mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0AGX )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bombyx mori
Silkmoth
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Danaus plexippus
Monarch butterfly
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis florea
Little honeybee
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Apis mellifera
Western honey bee
Apis mellifera
Western honey bee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus impatiens
Common eastern bumble bee
Bombus impatiens
Common eastern bumble bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Bombus terrestris
Buff-tailed bumblebee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Linepithema humile
Argentine ant
Linepithema humile
Argentine ant
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Megachile rotundata
Alfalfa leafcutting bee
Megachile rotundata
Alfalfa leafcutting bee
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Nasonia vitripennis
Parasitic wasp
Nasonia vitripennis
Parasitic wasp
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Tribolium castaneum
Red flour beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Cimex lectularius
Bed bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0E0L )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0UO7 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (1)
6 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 6 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser

    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    RNA-protein
    Physical Interaction
    Assay
    References
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement

    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Subunit Structure (UniProtKB)
    Homodimer (Probable). May interact with Unc-89 (via protein kinase domain 2) (PubMed:26251439).
    (UniProt, P06754 )
    Homodimer.
    (UniProt, P49455 )
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Gene Group - Pathway Membership (FlyBase)
    External Data
    Linkouts
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3R
    Recombination map
    3-56
    Cytogenetic map
    Sequence location
    3R:15,281,371..15,308,779 [+]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    88E12-88E13
    Limits computationally determined from genome sequence between P{lacW}MRG15j6A3 and P{PZ}l(3)0653606536
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    88E9-88E12
    (determined by in situ hybridisation)
    88F1-88F2
    (determined by in situ hybridisation)
    88F2-88F5
    (determined by in situ hybridisation)
    Experimentally Determined Recombination Data
    Location
    Left of (cM)
    Right of (cM)
    Notes
    Closely linked to Tm2.
    Stocks and Reagents
    Stocks (32)
    Genomic Clones (24)
    cDNA Clones (455)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequences
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    Other clones
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Antibody Information
    Laboratory Generated Antibodies
     
    polyclonal
    Commercially Available Antibodies
     
    Other Information
    Relationship to Other Genes
    Source for database identify of
    Source for identity of: Tm1 CG4898
    Source for database merge of
    Source for merge of: Tm1 l(3)S130510
    Source for merge of: Tm1 BcDNA:SD21996
    Source for merge of: Tm1 BcDNA:LD37158
    Source for merge of: Tm1 BcDNA:GH09289
    Additional comments
    Relationship between "l(3)88EFi" and "Tm1" is unclear; a temperature-sensitive "l(3)88EFi" allele partially complements Tm102299 at 29oC.
    Source for merge of Tm1 BcDNA:SD21996 was a shared cDNA ( date:030728 ).
    Source for merge of Tm1 BcDNA:LD37158 was a shared cDNA ( date:020730 ).
    Source for merge of Tm1 BcDNA:GH09289 was a shared cDNA ( date:030728 ).
    Other Comments
    The 'heavy tropomyosins', TmH-33 and TmH-34, are encoded by the Tm1 gene, using exons 16 and 15, respectively. They are specifically expressed in the indirect flight muscles.
    ChEST reveals this is a target of Mef2.
    dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation.
    Area matching Drosophila EST AI109898.
    GstS1 interacts with the TnH-34 isoform of troponin-H in asynchronous indirect flight muscle.
    Identification: Enhancer trap expression pattern survey for loci expressed in the ring gland.
    Tm1 is required for specific cell movements during head morphogenesis and for accumulating high levels of osk mRNA at the posterior pole necessary for germ cell formation but not for abdominal development.
    Tm1 regulatory regions have high affinity binding sites for Cf2, gel mobility shift assays reveal that Cf2 recognises a target site in the Tm1 enhancer region located in the first intron.
    Mutations in Tm1 virtually abolish osk RNA localisation to the posterior pole suggesting an involvement of the actin network in osk RNA localisation.
    Tm1 cis-acting sequences contain a 90bp muscle activator site (MA), the region is sufficient to direct low level transcriptional regulation of an Hsp70/Ecol\lacZ reporter gene in all somatic and visceral muscles of the embryo and adult.
    Gel mobility shift assays have revealed a Mef2 binding site in Tm1 gene proximal enhancer.
    Tm1 mRNA synthesis and accumulation in the developing ovary and embryo has been studied. lac reporter gene constructs demonstrate 1.2kb of 5' sequence upstream of the Tm1 transcription start site is required to drive expression of both the maternal and zygotic transcripts in the nurse cells and embryo but not in the follicle cells of the ovariole.
    The distribution of muscle enhancer elements and their control is similar to those regulating the expression of Tm1.
    Tm1 transcription is controlled by multiple muscle type-specific cis-acting control elements and upstream and downstream promoter control elements.
    Three variants of Tm1 have been determined, this variation does not affect flight ability.
    Three variants of Tm1 have been determined by their mobility on 1-D and 2-D SDS-PAGE.
    Tm1 acts as a regulator of motility in muscle and nonmuscle cells.
    Structural gene for tropomyosin, a 34,000-dalton protein. At least five tropomyosin isoforms are encoded by Tm1, some in embryos (during myogenesis) and myogenic cell culture and others in the myofibrils of adult indirect flight muscles and leg muscles.
    Tm1, muscle promoter of Tm2, Act57B and Mlc2 were not transcribed by embryonic extracts. The contractile protein genes may possess a common feature related to in vitro transcription that prevents their transcription.
    Tm1 has been cloned and sequenced.
    Tm1 has been sequenced, and its expression pattern analysed.
    Defined during molecular analysis of the 88F region.
    Origin and Etymology
    Discoverer
    Etymology
    Identification
    External Crossreferences and Linkouts ( 144 )
    Sequence Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
    Other crossreferences
    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    Flygut - An atlas of the Drosophila adult midgut
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
    InterPro - A database of protein families, domains and functional sites
    KEGG Genes - Molecular building blocks of life in the genomic space.
    modMine - A data warehouse for the modENCODE project
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DPiM - Drosophila Protein interaction map
    DroID - A comprehensive database of gene and protein interactions.
    DRSC - Results frm RNAi screens
    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    FlyMine - An integrated database for Drosophila genomics
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    Synonyms and Secondary IDs (54)
    Reported As
    Symbol Synonym
    BcDNA:GH09289
    BcDNA:LD37158
    BcDNA:SD21996
    PmI
    chr3R:11122272..11122408
    l(3)02299
    l(3)s2958
    Name Synonyms
    cytoplasmic tropomyosin
    cytoskeletal Tropomyosin
    tropomyosinII
    troponin H
    troponin-H isoform 34
    Secondary FlyBase IDs
    • FBgn0010776
    • FBgn0011036
    • FBgn0015832
    • FBgn0015833
    • FBgn0046771
    • FBgn0046800
    • FBgn0060408
    • FBgn0064771
    Datasets (0)
    Study focus (0)
    Experimental Role
    Project
    Project Type
    Title
    References (267)