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Gene Dmel\Tm1

General Information
Symbol	Dmel\Tm1	Species	D. melanogaster
Name	Tropomyosin 1	Annotation symbol	CG4898
Feature type	protein_coding_gene	FlyBase ID	FBgn0003721
Gene Model Status	Current	Stock availability	22 publicly available
Also Known As	TmII, cTm, Tm, TnH, cTmII, mTmII, TnH-34, TmH-33, TmH-34
Genomic Location
Chromosome (arm)	3R	Recombination map	3-56.75 +/- 0.92
Cytogenetic map	88E12-88E13	Sequence location	3R:11,107,093..11,134,501 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Tropomyosin 1 is referred to in FlyBase by the symbol Dmel\Tm1 (CG4898, FBgn0003721). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: actin filament binding. There is experimental evidence that it is involved in the biological process: regulation of lamellipodium assembly; dendrite morphogenesis; pole plasm oskar mRNA localization. 56 alleles are reported. The phenotypes of these alleles are annotated with: pole cell; germline cell; mesothoracic tergum; border follicle cell. It has 17 annotated transcripts and 17 annotated polypeptides. Protein features are: Tropomyosin. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 12-24 hour embryonic stages, at stages throughout the larval period, during late pupal stages, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression in all larval and adult organs/tissues ranges from low to undetected. Expression at high levels in the following post-embryonic organs or tissues: adult head, larval central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, adult central nervous system, larval/adult fat body, adult testis. Gene sequence location is 3R:11107093..11134501.
User Contributed Data
	Beta version, feedback welcome
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	Tm1: Tropomyosin 1 (J.C. Hall) Structural gene for tropomyosin, a 34,000-dalton protein that acts as a regulator of motility in muscle and nonmuscle cells. At least five tropomyosin isoforms are encoded by Tm1, some in embryos (during myogenesis) and myogenic cell culture and others in the myofibrils of adult indirect flight muscles and leg muscles.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 88E12-88E13   Limits computationally determined from genome sequence between P{lacW}MRG15j6A3 and P{PZ}l(3)0653606536
Experimentally Determined Cytological Location
Cytogenetic map Notes References 88E9-88E12   (determined by in situ hybridisation)   (Ranz et al., 2001) 88F1-88F2   (determined by in situ hybridisation)   (Spradling et al., 1999) 88F1-88F2     (BDGP Project Members, 1994-1999) 88F2-88F5   (determined by in situ hybridisation)   (Bautch et al., 1982)
Experimentally Determined Recombination Data
Location	3-56.75 +/- 0.92 (Cripps and Sparrow, 1992)
Left of (cM)
Right of (cM)
Notes	Closely linked to Tm2.
Gene Model & Products
Please see the GBrowse view of Dmel\Tm1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.46 Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters. Annotated transcripts do not represent all supported alternative splices within 5' UTR. Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Tm1-RA FBtr0089960  NM_079636   2003   252 Tm1-RC FBtr0089962  NM_169640   2651   441 Tm1-RE FBtr0089965  NM_169638   2531   711 Tm1-RF FBtr0089959  NM_169637   1684   501 Tm1-RG FBtr0089964  NM_169635   2485   285 Tm1-RH FBtr0089963  NM_169639   3054   678 Tm1-RI FBtr0089961  NM_169641   2501   441 Tm1-RJ FBtr0089967  NM_169636   1248   285 Tm1-RK FBtr0089957  NM_206495   1665   518 Tm1-RL FBtr0089968  NM_206494   2194   284 Tm1-RM FBtr0301959  NM_169634   1253   285 Tm1-RN FBtr0301960  NM_001170148   1253   285 Tm1-RO FBtr0305654  NM_169633   1503   285 Tm1-RP FBtr0305655  NM_001260190   752   161 Tm1-RQ FBtr0305656  NM_001260191   1318   250 Tm1-RR FBtr0333917  NM_001275661   1861   250 Tm1-RS FBtr0333918  NM_001275662   1253   285
Additional Transcript Data & Comments
Reported size (kB)	1.253 (longest cDNA) (Hanke and Storti, 1986)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Tm1-PA   FBpp0088899   29.3   252   4.47     NP_524360   AAF55164 Tm1-PC   FBpp0088901   48.0   441   5.15     NP_732008   AAN13650 Tm1-PE   FBpp0088904   80.1   711   5.09     NP_732006   AAN13648 Tm1-PF   FBpp0088898   53.4   501   4.05     NP_732005   AAN13647 Tm1-PG   FBpp0088903   32.7   285   4.38     NP_732003   AAN13645 Tm1-PH   FBpp0088902   74.7   678   9.49     NP_732007   AAN13649 Tm1-PI   FBpp0088900   48.0   441   5.15     NP_732009   AAN13651 Tm1-PJ   FBpp0088906   32.7   285   4.38     NP_732004   AAN13646 Tm1-PK   FBpp0088896   54.6   518   4.08     NP_996217   AAS65155 Tm1-PL   FBpp0089024   32.5   284   4.43     NP_996216   AAS65156 Tm1-PM   FBpp0291171   32.7   285   4.38     NP_732002   AAN13644 Tm1-PN   FBpp0291172   32.8   285   4.40     NP_001163619   ACZ94915 Tm1-PO   FBpp0296934   32.7   285   4.38     NP_732001   AAF55163 Tm1-PP   FBpp0296935   18.4   161   5.02     NP_001247119   AFH06437 Tm1-PQ   FBpp0296936   29.2   250   4.54     NP_001247120   AFH06438 Tm1-PR   FBpp0306045   29.1   250   4.54     NP_001262590   AGB95971 Tm1-PS   FBpp0306046   32.7   285   4.40     NP_001262591   AGB95972
Additional Polypeptide Data & Comments
Reported size (kDa)	518, 504, 285, 252 (aa) (Hanke and Storti, 1988)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Tropomyosin (IPR000533)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202601   AA202602   AA246409   AA246548   AA263218   AA263301   AA263606   AA263862   AA391351   AA392213   AA439049   AA440134   AA441199   AA441442   AA539395   AA540574   AA540989   AA567134   AA567812   AA696143   AA697015   AA735557   AA816806   AA948849   AA949162   AA949170   AA950107   AA951170   AA951441   AA978445   AA979302   AE014297 AAF55163   AE014297 AAF55164   AE014297 AAN13644   AE014297 AAN13645   AE014297 AAN13646   AE014297 AAN13647   AE014297 AAN13648   AE014297 AAN13649   AE014297 AAN13650   AE014297 AAN13651   AE014297 AAS65155   AE014297 AAS65156   AE014297 ACZ94915   AE014297 AFH06437   AE014297 AFH06438   AE014297 AGB95971   AE014297 AGB95972   AI109898   AI135030   AI258170   AI259204   AI294746   AI295105   AI296212   AI297396   AI405344   AI454954   AI456972   AI512162   AI513440   AI513457   AI516461   AI516999   AI517218   AI520049   AI520102   AI531912   AI533809   AI534294   AI945031   AK281119   AW940314   AW943369   AX094111   AY060262 AAL25301   AY060414 AAL25453   AY084208   AY231730   BF505995   BG633523   BG637721   BG638606   BI163159   BI163426   BI163436   BI163655   BI164146   BI164280   BI164465   BI164533   BI164925   BI165124   BI165250   BI166041   BI166257   BI167037   BI167370   BI167571   BI167669   BI167933   BI168208   BI168330   BI168615   BI168659   BI168947   BI169190   BI169287   BI169463   BI170117   BI170160   BI170738   BI170950   BI171202   BI171429   BI171549   BI171821   BI172817   BI172935   BI173017   BI173145   BI173201   BI173303   BI173852   BI173861   BI212486   BI212741   BI213090   BI213233   BI213719   BI213860   BI214012   BI214127   BI214144   BI214152   BI214452   BI214724   BI214823   BI215277   BI216117   BI216207   BI216317   BI216611   BI216696   BI216771   BI216803   BI227606   BI227648   BI228177   BI229019   BI229153   BI229547   BI230032   BI230246   BI230762   BI230986   BI230993   BI231351   BI231388   BI231503   BI231668   BI231823   BI232819   BI233068   BI233079   BI233263   BI234383   BI235897   BI236138   BI236400   BI236887   BI236947   BI237914   BI238205   BI238279   BI239012   BI239395   BI239479   BI239531   BI242980   BI243121   BI243135   BI243140   BI243703   BI243786   BI243962   BI351833   BI355921   BI356207   BI356557   BI356736   BI356939   BI357291   BI357297   BI357307   BI357316   BI357341   BI357962   BI357976   BI358606   BI361410   BI361695   BI362361   BI362418   BI362420   BI362421   BI362429   BI362875   BI363963   BI363971   BI364180   BI364345   BI364361   BI365518   BI365528   BI365764   BI365930   BI365947   BI366360   BI366361   BI366457   BI366689   BI366878   BI367011   BI367127   BI367199   BI367697   BI367760   BI368296   BI368398   BI368669   BI368945   BI368954   BI369159   BI369593   BI369730   BI369792   BI369866   BI369883   BI370132   BI370588   BI370641   BI370715   BI370749   BI370849   BI371043   BI371086   BI371274   BI371627   BI372716   BI373634   BI373760   BI373858   BI374755   BI374888   BI374928   BI375373   BI375527   BI376046   BI481535   BI481745   BI482341   BI482545   BI483135   BI483353   BI484040   BI485004   BI486242   BI486442   BI487039   BI487051   BI487166   BI565246   BI569397   BI569398   BI570043   BI570046   BI570049   BI570408   BI571544   BI572530   BI573137   BI577324   BI578437   BI578761   BI578766   BI578924   BI578955   BI579334   BI580264   BI580707   BI581239   BI581273   BI582568   BI583343   BI584822   BI587586   BI589957   BI592261   BI592747   BI592884   BI593049   BI593460   BI604413   BI604517   BI608629   BI609081   BI609395   BI609589   BI609785   BI609958   BI610253   BI610449   BI610536   BI610888   BI611380   BI617854   BI619121   BI624789   BI639426   BI641133   BP544908   BP544909   BP545095   BP545096   BP553936   BP553937   BQ103285   BT001534 AAN71289   BT001902 AAN71691   BT003786   BT011469   BT029125   BT081362   BT133132   CK131389   CK656999   CL844495   CO181410   CO185709   CO186229   CO186230   CO186537   CO186570   CO188380   CO188645   CO188666   CO189132   CO192169   CO262069   CO262932   CO265366   CO267490   CO267503   CO268749   CO270966   CO271646   CO272158   CO272174   CO272625   CO272808   CO273323   CO273419   CO275163   CO276492   CO277359   CO277417   CO277863   CO278912   CO282789   CO285332   CO285888   CO286945   CO287582   CO288232   CO288325   CO288987   CO291455   CO291715   CO293773   CO294461   CO295833   CO300279   CO300316   CO302186   CO302906   CO303099   CO303312   CO303602   CO305000   CO305848   CO305918   CO309257   CO311216   CO311634   CO311969   CO313551   CO314580   CO314857   CO314978   CO319008   CO322849   CO324993   CO325163   CO326227   CO326359   CO326825   CO326884   CO328041   CO329238   CO329494   CO332105   CO332142   CO332547   CO333243   CO333756   CO333801   CO336125   CO336915   CO336949   CO340346   CO340563   CO345239   CZ469463   CZ471925   CZ478856   CZ478978   CZ478979   CZ481166   CZ481172   CZ482841   EC057538   EC058445   EC058597   EC059195   EC059717   EC060410   EC060648   EC063512   EC063832   EC064991   EC067917   EC068538   EC068770   EC068983   EC070925   EC072810   EC074284   EC074483   EC075290   EC076275   EC076825   EC079911   EC081543   EC082057   EC082372   EC082797   EC083380   EC085544   EC085629   EC088147   EC088397   EC089222   EC089864   EC090182   EC090827   EC194633   EC195296   EC196648   EC197028   EC197628   EC197790   EC197866   EC198768   EC199186   EC200613   EC201363   EC205896   EC206758   EC207599   EC207938   EC207939   EC208393   EC209212   EC209921   EC211523   EC212228   EC212647   EC213527   EC214377   EC214444   EC214805   EC217011   EC218132   EC219056   EC220534   EC221586   EC222519   EC223901   EC225979   EC226102   EC226121   EC226929   EC227130   EC227351   EC228156   EC229549   EC232501   EC234115   EC234589   EC234774   EC235873   EC239898   EC240740   EC240954   EC241906   EC243665   EC249696   EC250697   EC251163   EC251599   EC251875   EC252807   EC254378   EC258157   EC259594   EC259756   EC259873   EC264240   EC265139   EL876246   EL876320   EL876396   EL884887   EL884897   EL885008   EL885131   ES695587   EV590438   EV592913   GH942746   GH958660   GH973769   J03502 AAA28972   K02620 AAA28967   K02621 AAA28968   L00355 AAA28965   L00355 AAA28966   L00355 AAA28967   L00355 AAA28968   L00355 AAA28969   L00356 AAA28965   L00356 AAA28966   L00356 AAA28967   L00356 AAA28968   L00356 AAA28969   L00357 AAA28965   L00357 AAA28966   L00357 AAA28967   L00357 AAA28968   L00357 AAA28969   L00358 AAA28965   L00358 AAA28966   L00358 AAA28967   L00358 AAA28968   L00358 AAA28969   L00359 AAA28965   L00359 AAA28966   L00359 AAA28967   L00359 AAA28968   L00359 AAA28969   L00360 AAA28966   L00360 AAA28967   L00360 AAA28968   L00360 AAA28969   L00361 AAA28965   L00362 AAA28965   L00362 AAA28966   L00362 AAA28967   L00362 AAA28968   L00362 AAA28969   L00363 AAA28966   M12840 AAA28965   M12840 AAA28966   M12840 AAA28967   M12840 AAA28968   M12840 AAA28969   M13023 AAA28969   M15466 AAA28975   X76208 CAA53800   X76208 CAA53801
UniProtKB/Swiss-Prot	P06754 P49455
UniProtKB/TrEMBL	Q8IG84 Q8IGY1 Q95TA3 Q6NN28 Q6LEH1
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References regulatory region FBsf0000435600 3R:11,136,419..11,136,478 evidence=Reporter construct (in vivo) (Lin et al., 1997, Halfon, 2012.6.19)
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage | early   embryo | posterior   (Hales et al., 1994) embryonic cortex   (Hales et al., 1994) embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 1 -- 4   pole plasm | posterior   (Lecuyer et al., 2007) embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 5   pole cell   (Lecuyer et al., 2007) embryonic stage 6 -- 11   ventral furrow   (Hales et al., 1994) germ band   (Hales et al., 1994) cephalic furrow   (Hales et al., 1994) embryonic stage 6 -- 15   posterior midgut primordium   (Hales et al., 1994) anterior midgut primordium   (Hales et al., 1994) embryonic stage 7 -- 8   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 11   ectoderm | segmentally repeated   (Hales et al., 1994) embryonic stage 11 -- 12   anterior midgut primordium   (Fisher et al., 2012) dorsal epidermis primordium   (Fisher et al., 2012) foregut primordium   (Fisher et al., 2012) hindgut proper primordium   (Fisher et al., 2012) Malpighian tubule primordium   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) posterior midgut primordium   (Fisher et al., 2012) somatic muscle primordium   (Fisher et al., 2012) ventral epidermis primordium   (Fisher et al., 2012) visceral muscle primordium   (Fisher et al., 2012) embryonic stage 13   dorsal ectoderm   (Hales et al., 1994) embryonic stage 13 -- 16   adult muscle precursor primordium   (Fisher et al., 2012) dorsal pharyngeal muscle   (Fisher et al., 2012) embryonic brain   (Fisher et al., 2012) embryonic dorsal epidermis   (Fisher et al., 2012) embryonic foregut   (Fisher et al., 2012) embryonic hindgut   (Fisher et al., 2012) embryonic Malpighian tubule   (Fisher et al., 2012) embryonic ventral epidermis   (Fisher et al., 2012) embryonic/larval midgut   (Fisher et al., 2012) embryonic/larval muscle system   (Fisher et al., 2012) embryonic/larval somatic muscle   (Fisher et al., 2012) embryonic/larval visceral muscle   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) embryonic stage 13 -- 17   presumptive embryonic/larval central nervous system   (Hales et al., 1994) embryonic brain   (Hales et al., 1994) midgut constriction   (Hales et al., 1994) embryonic stage 16   embryonic/larval somatic muscle   (Lord et al., 1995) adult stageoogenesis stage S10 -- S12   nurse cell   (Hales et al., 1994) follicle cell   (Hales et al., 1994) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 11     (Hales et al., 1994) Comment:reference states 0-6 hr AEL embryonic stage 8 -- 17     (Hales et al., 1994) Comment:reference states >3-6 hr AEL
Additional Descriptive Data
	Tm1 expression at embryonic stages 1-4 is localized to the posterior pole of the embryo. (Lecuyer et al., 2007)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011) western blot Stage Tissue/Position (including subcellular localization) Reference adult stage   indirect flight muscle   (Clayton et al., 1998)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
colocalizes_with filamentous actin inferred from direct assay (Texada et al., 2011) investment cone inferred from direct assay (Texada et al., 2011) sarcomere inferred from direct assay (Hudson et al., 2008) colocalizes_with sarcoplasmic reticulum inferred from direct assay (Texada et al., 2011)
Expression Deduced from Reporters
Reporter: P{+167-1367HSP} Stage Tissue/Position (including subcellular localization) Reference embryonic stage & larval stage & adult stage   muscle system   (Meredith and Storti, 1993) Reporter: P{+167-621-1400PIΔ1.2} Stage Tissue/Position (including subcellular localization) Reference embryonic stage & larval stage & adult stage   muscle system   (Meredith and Storti, 1993) Reporter: P{+167-621HSP} Stage Tissue/Position (including subcellular localization) Reference embryonic stage & larval stage & adult stage   muscle system   (Meredith and Storti, 1993) Reporter: P{-1200LACcTm-3'} Stage Tissue/Position (including subcellular localization) Reference embryonic stage | early   organism | posterior   (Hales et al., 1994) embryonic cortex   (Hales et al., 1994) embryonic stage 6 -- 11   germ band   (Hales et al., 1994) cephalic furrow   (Hales et al., 1994) ventral furrow   (Hales et al., 1994) embryonic stage 6 -- 15   posterior midgut primordium   (Hales et al., 1994) anterior midgut primordium   (Hales et al., 1994) embryonic stage 11   ectoderm | segmentally repeated   (Hales et al., 1994) embryonic stage 13   dorsal ectoderm   (Hales et al., 1994) embryonic stage 13 -- 17   midgut constriction   (Hales et al., 1994) presumptive embryonic/larval central nervous system   (Hales et al., 1994) embryonic brain   (Hales et al., 1994) adult stage & oogenesis   oocyte   (Hales et al., 1994) nurse cell   (Hales et al., 1994) Reporter: P{-1400PIΔ1.2} Stage Tissue/Position (including subcellular localization) Reference embryonic stage & larval stage & adult stage   muscle system | restricted   (Meredith and Storti, 1993) Reporter: P{-1400PIΔBglII} Stage Tissue/Position (including subcellular localization) Reference embryonic stage & larval stage & adult stage   muscle system   (Meredith and Storti, 1993) Reporter: P{-1400PI} Stage Tissue/Position (including subcellular localization) Reference embryonic stage & larval stage & adult stage   muscle system   (Meredith and Storti, 1993) Reporter: P{-22-1367HSP} Stage Tissue/Position (including subcellular localization) Reference embryonic stage & larval stage & adult stage   muscle system   (Meredith and Storti, 1993) Reporter: P{-22PI} Stage Tissue/Position (including subcellular localization) Reference embryonic stage & larval stage & adult stage   muscle system   (Meredith and Storti, 1993) Reporter: P{-243PI} Stage Tissue/Position (including subcellular localization) Reference embryonic stage & larval stage & adult stage   muscle system   (Meredith and Storti, 1993) Reporter: P{GawB}Tm1C817 Stage Tissue/Position (including subcellular localization) Reference pupal stage   morphogenetic furrow | posterior to   (Wernet et al., 2003) photoreceptor cell of morphogenetic furrow | posterior to   (Wernet et al., 2003) photoreceptor cell | subset   (Wernet et al., 2003) adult stage   central nervous system | restricted   (Sarpal et al., 2003) neuron of central nervous system | subset   (Sarpal et al., 2003) neuron | subset   (Sarpal et al., 2003) chordotonal organ   (Sarpal et al., 2003) Reporter: P{PTT-GC}Tm1G5 Stage Tissue/Position (including subcellular localization) Reference adult stage   muscle cell   • sarcomere (Morin et al., 2001)
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression in all larval and adult organs/tissues ranges from low to undetected. Expression at high levels in the following post-embryonic organs or tissues: adult head, larval central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, adult central nervous system, larval/adult fat body, adult testis. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    88 central nervous system, larvae L3    85 central nervous system, pupae P8    57 head, virgin 1-day female    106 head, virgin 4-day female    40 head, virgin 20-day female    17 head, mated 1-day female    83 head, mated 4-day female    29 head, mated 20-day female    19 head, mated 1-day male    79 head, mated 4-day male    37 head, mated 20-day male    29 salivary gland, larvae L3 wandering    194 salivary gland, white prepupae    307 digestive system, larvae L3 wandering    110 digestive system, 1-day adult    68 digestive system, 4-day adult    87 digestive system, 20-day adult    57 fat body, larvae L3 wandering    34 fat body, white prepupae    47 fat body, pupae P8    70 carcass, larvae L3 wandering    204 carcass, 1-day adult    205 carcass, 4-day adult    79 carcass, 20-day adult    41 ovary, virgin 4-day female    80 ovary, mated 4-day female    153 testis, mated 4-day male    19 accessory gland, mated 4-day male    31 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (88) central nervous system, larvae L3  (85) central nervous system, pupae P8  (57) head, virgin 1-day female  (106) head, virgin 4-day female  (40) head, virgin 20-day female    17 head, mated 1-day female  (83) head, mated 4-day female  (29) head, mated 20-day female    19 head, mated 1-day male  (79) head, mated 4-day male  (37) head, mated 20-day male  (29) salivary gland, larvae L3 wandering  (194) salivary gland, white prepupae  (307) digestive system, larvae L3 wandering  (110) digestive system, 1-day adult  (68) digestive system, 4-day adult  (87) digestive system, 20-day adult  (57) fat body, larvae L3 wandering  (34) fat body, white prepupae  (47) fat body, pupae P8  (70) carcass, larvae L3 wandering  (204) carcass, 1-day adult  (205) carcass, 4-day adult  (79) carcass, 20-day adult  (41) ovary, virgin 4-day female  (80) ovary, mated 4-day female  (153) testis, mated 4-day male    19 accessory gland, mated 4-day male  (31) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    88 central nervous system, larvae L3    85 central nervous system, pupae P8    57 head, virgin 1-day female  106 head, virgin 4-day female    40 head, virgin 20-day female    17 head, mated 1-day female    83 head, mated 4-day female    29 head, mated 20-day female    19 head, mated 1-day male    79 head, mated 4-day male    37 head, mated 20-day male    29 salivary gland, larvae L3 wandering  (194) salivary gland, white prepupae  (307) digestive system, larvae L3 wandering  (110) digestive system, 1-day adult    68 digestive system, 4-day adult    87 digestive system, 20-day adult    57 fat body, larvae L3 wandering    34 fat body, white prepupae    47 fat body, pupae P8    70 carcass, larvae L3 wandering  (204) carcass, 1-day adult  (205) carcass, 4-day adult    79 carcass, 20-day adult    41 ovary, virgin 4-day female    80 ovary, mated 4-day female  (153) testis, mated 4-day male    19 accessory gland, mated 4-day male    31 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    88 central nervous system, larvae L3    85 central nervous system, pupae P8    57 head, virgin 1-day female    106 head, virgin 4-day female    40 head, virgin 20-day female    17 head, mated 1-day female    83 head, mated 4-day female    29 head, mated 20-day female    19 head, mated 1-day male    79 head, mated 4-day male    37 head, mated 20-day male    29 salivary gland, larvae L3 wandering    194 salivary gland, white prepupae    307 digestive system, larvae L3 wandering    110 digestive system, 1-day adult    68 digestive system, 4-day adult    87 digestive system, 20-day adult    57 fat body, larvae L3 wandering    34 fat body, white prepupae    47 fat body, pupae P8    70 carcass, larvae L3 wandering    204 carcass, 1-day adult    205 carcass, 4-day adult    79 carcass, 20-day adult    41 ovary, virgin 4-day female    80 ovary, mated 4-day female    153 testis, mated 4-day male    19 accessory gland, mated 4-day male    31 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    88 central nervous system, larvae L3    85 central nervous system, pupae P8    57 head, virgin 1-day female    106 head, virgin 4-day female    40 head, virgin 20-day female    17 head, mated 1-day female    83 head, mated 4-day female    29 head, mated 20-day female    19 head, mated 1-day male    79 head, mated 4-day male    37 head, mated 20-day male    29 salivary gland, larvae L3 wandering    194 salivary gland, white prepupae    307 digestive system, larvae L3 wandering    110 digestive system, 1-day adult    68 digestive system, 4-day adult    87 digestive system, 20-day adult    57 fat body, larvae L3 wandering    34 fat body, white prepupae    47 fat body, pupae P8    70 carcass, larvae L3 wandering    204 carcass, 1-day adult    205 carcass, 4-day adult    79 carcass, 20-day adult    41 ovary, virgin 4-day female    80 ovary, mated 4-day female    153 testis, mated 4-day male    19 accessory gland, mated 4-day male    31 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (88) central nervous system, larvae L3  (85) central nervous system, pupae P8  (57) head, virgin 1-day female  (106) head, virgin 4-day female  (40) head, virgin 20-day female    17 head, mated 1-day female  (83) head, mated 4-day female  29 head, mated 20-day female    19 head, mated 1-day male  (79) head, mated 4-day male  (37) head, mated 20-day male  29 salivary gland, larvae L3 wandering  (194) salivary gland, white prepupae  (307) digestive system, larvae L3 wandering  (110) digestive system, 1-day adult  (68) digestive system, 4-day adult  (87) digestive system, 20-day adult  (57) fat body, larvae L3 wandering  (34) fat body, white prepupae  (47) fat body, pupae P8  (70) carcass, larvae L3 wandering  (204) carcass, 1-day adult  (205) carcass, 4-day adult  (79) carcass, 20-day adult  (41) ovary, virgin 4-day female  (80) ovary, mated 4-day female  (153) testis, mated 4-day male    19 accessory gland, mated 4-day male  31 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    88 central nervous system, larvae L3    85 central nervous system, pupae P8    57 head, virgin 1-day female  106 head, virgin 4-day female    40 head, virgin 20-day female    17 head, mated 1-day female    83 head, mated 4-day female    29 head, mated 20-day female    19 head, mated 1-day male    79 head, mated 4-day male    37 head, mated 20-day male    29 salivary gland, larvae L3 wandering  (194) salivary gland, white prepupae  (307) digestive system, larvae L3 wandering  110 digestive system, 1-day adult    68 digestive system, 4-day adult    87 digestive system, 20-day adult    57 fat body, larvae L3 wandering    34 fat body, white prepupae    47 fat body, pupae P8    70 carcass, larvae L3 wandering  (204) carcass, 1-day adult  (205) carcass, 4-day adult    79 carcass, 20-day adult    41 ovary, virgin 4-day female    80 ovary, mated 4-day female  (153) testis, mated 4-day male    19 accessory gland, mated 4-day male    31 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    88 central nervous system, larvae L3    85 central nervous system, pupae P8    57 head, virgin 1-day female    106 head, virgin 4-day female    40 head, virgin 20-day female    17 head, mated 1-day female    83 head, mated 4-day female    29 head, mated 20-day female    19 head, mated 1-day male    79 head, mated 4-day male    37 head, mated 20-day male    29 salivary gland, larvae L3 wandering    194 salivary gland, white prepupae    307 digestive system, larvae L3 wandering    110 digestive system, 1-day adult    68 digestive system, 4-day adult    87 digestive system, 20-day adult    57 fat body, larvae L3 wandering    34 fat body, white prepupae    47 fat body, pupae P8    70 carcass, larvae L3 wandering    204 carcass, 1-day adult    205 carcass, 4-day adult    79 carcass, 20-day adult    41 ovary, virgin 4-day female    80 ovary, mated 4-day female    153 testis, mated 4-day male    19 accessory gland, mated 4-day male    31 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 12-24 hour embryonic stages, at stages throughout the larval period, during late pupal stages, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    35 embryo 02-04hr    49 embryo 04-06hr    35 embryo 06-08hr    33 embryo 08-10hr    37 embryo 10-12hr    39 embryo 12-14hr    64 embryo 14-16hr    83 embryo 16-18hr    156 embryo 18-20hr    215 embryo 20-22hr    206 embryo 22-24hr    216 larva L1    126 larva L2    153 larva L3 12hr old    219 larva L3 puffstage 1-2    167 larva L3 puffstage 3-6    95 larva L3 puffstage 7-9    60 white prepupae new    38 white prepupae 12hr    31 white prepupae 24hr    30 pupae 2d postWPP    53 pupae 3d postWPP    279 pupae 4d postWPP    324 adult male 01day    164 adult male 05day    54 adult male 30day    25 adult female 01day    126 adult female 05day    39 adult female 30day    34 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (35) embryo 02-04hr  (49) embryo 04-06hr  (35) embryo 06-08hr  (33) embryo 08-10hr  (37) embryo 10-12hr  (39) embryo 12-14hr  (64) embryo 14-16hr  (83) embryo 16-18hr  (156) embryo 18-20hr  (215) embryo 20-22hr  (206) embryo 22-24hr  (216) larva L1  (126) larva L2  (153) larva L3 12hr old  (219) larva L3 puffstage 1-2  (167) larva L3 puffstage 3-6  (95) larva L3 puffstage 7-9  (60) white prepupae new  (38) white prepupae 12hr  (31) white prepupae 24hr  (30) pupae 2d postWPP  (53) pupae 3d postWPP  (279) pupae 4d postWPP  (324) adult male 01day  (164) adult male 05day  (54) adult male 30day    25 adult female 01day  (126) adult female 05day  (39) adult female 30day  (34) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    35 embryo 02-04hr    49 embryo 04-06hr    35 embryo 06-08hr    33 embryo 08-10hr    37 embryo 10-12hr    39 embryo 12-14hr    64 embryo 14-16hr    83 embryo 16-18hr  (156) embryo 18-20hr  (215) embryo 20-22hr  (206) embryo 22-24hr  (216) larva L1  (126) larva L2  (153) larva L3 12hr old  (219) larva L3 puffstage 1-2  (167) larva L3 puffstage 3-6    95 larva L3 puffstage 7-9    60 white prepupae new    38 white prepupae 12hr    31 white prepupae 24hr    30 pupae 2d postWPP    53 pupae 3d postWPP  (279) pupae 4d postWPP  (324) adult male 01day  (164) adult male 05day    54 adult male 30day    25 adult female 01day  (126) adult female 05day    39 adult female 30day    34 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    35 embryo 02-04hr    49 embryo 04-06hr    35 embryo 06-08hr    33 embryo 08-10hr    37 embryo 10-12hr    39 embryo 12-14hr    64 embryo 14-16hr    83 embryo 16-18hr    156 embryo 18-20hr    215 embryo 20-22hr    206 embryo 22-24hr    216 larva L1    126 larva L2    153 larva L3 12hr old    219 larva L3 puffstage 1-2    167 larva L3 puffstage 3-6    95 larva L3 puffstage 7-9    60 white prepupae new    38 white prepupae 12hr    31 white prepupae 24hr    30 pupae 2d postWPP    53 pupae 3d postWPP    279 pupae 4d postWPP    324 adult male 01day    164 adult male 05day    54 adult male 30day    25 adult female 01day    126 adult female 05day    39 adult female 30day    34 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    35 embryo 02-04hr    49 embryo 04-06hr    35 embryo 06-08hr    33 embryo 08-10hr    37 embryo 10-12hr    39 embryo 12-14hr    64 embryo 14-16hr    83 embryo 16-18hr    156 embryo 18-20hr    215 embryo 20-22hr    206 embryo 22-24hr    216 larva L1    126 larva L2    153 larva L3 12hr old    219 larva L3 puffstage 1-2    167 larva L3 puffstage 3-6    95 larva L3 puffstage 7-9    60 white prepupae new    38 white prepupae 12hr    31 white prepupae 24hr    30 pupae 2d postWPP    53 pupae 3d postWPP    279 pupae 4d postWPP    324 adult male 01day    164 adult male 05day    54 adult male 30day    25 adult female 01day    126 adult female 05day    39 adult female 30day    34 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (35) embryo 02-04hr  (49) embryo 04-06hr  (35) embryo 06-08hr  (33) embryo 08-10hr  (37) embryo 10-12hr  (39) embryo 12-14hr  (64) embryo 14-16hr  (83) embryo 16-18hr  (156) embryo 18-20hr  (215) embryo 20-22hr  (206) embryo 22-24hr  (216) larva L1  (126) larva L2  (153) larva L3 12hr old  (219) larva L3 puffstage 1-2  (167) larva L3 puffstage 3-6  (95) larva L3 puffstage 7-9  (60) white prepupae new  (38) white prepupae 12hr  31 white prepupae 24hr  30 pupae 2d postWPP  (53) pupae 3d postWPP  (279) pupae 4d postWPP  (324) adult male 01day  (164) adult male 05day  (54) adult male 30day    25 adult female 01day  (126) adult female 05day  (39) adult female 30day  (34) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    35 embryo 02-04hr    49 embryo 04-06hr    35 embryo 06-08hr    33 embryo 08-10hr    37 embryo 10-12hr    39 embryo 12-14hr    64 embryo 14-16hr    83 embryo 16-18hr  (156) embryo 18-20hr  (215) embryo 20-22hr  (206) embryo 22-24hr  (216) larva L1  126 larva L2  (153) larva L3 12hr old  (219) larva L3 puffstage 1-2  (167) larva L3 puffstage 3-6    95 larva L3 puffstage 7-9    60 white prepupae new    38 white prepupae 12hr    31 white prepupae 24hr    30 pupae 2d postWPP    53 pupae 3d postWPP  (279) pupae 4d postWPP  (324) adult male 01day  (164) adult male 05day    54 adult male 30day    25 adult female 01day  126 adult female 05day    39 adult female 30day    34 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    35 embryo 02-04hr    49 embryo 04-06hr    35 embryo 06-08hr    33 embryo 08-10hr    37 embryo 10-12hr    39 embryo 12-14hr    64 embryo 14-16hr    83 embryo 16-18hr    156 embryo 18-20hr    215 embryo 20-22hr    206 embryo 22-24hr    216 larva L1    126 larva L2    153 larva L3 12hr old    219 larva L3 puffstage 1-2    167 larva L3 puffstage 3-6    95 larva L3 puffstage 7-9    60 white prepupae new    38 white prepupae 12hr    31 white prepupae 24hr    30 pupae 2d postWPP    53 pupae 3d postWPP    279 pupae 4d postWPP    324 adult male 01day    164 adult male 05day    54 adult male 30day    25 adult female 01day    126 adult female 05day    39 adult female 30day    34 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    91 Schneider line 2 Sg4    33 embryonic 1182-4H    123 embryonic GM2    57 embryonic Kc167    66 embryonic S1    77 embryonic S3    66 leg disc CME L1    65 wing disc CME-W2    44 wing disc ML-DmD8    91 wing disc ML-DmD9    121 wing disc ML-DmD16-c3    103 wing disc ML-DmD21    60 wing disc ML-DmD32    184 haltere disc ML-DmD17-c3    93 eye-antennal disc ML-DmD11    102 antennal disc ML-DmD20-c5    77 mixed discs ML-DmD4-c1    101 CNS ML-DmBG1-c1    80 CNS ML-DmBG2-c2    38 tumorous blood cells mbn2    52 ovary fGS/OSS    112 ovary OSC    160 ovary OSS    95 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (91) Schneider line 2 Sg4  (33) embryonic 1182-4H  (123) embryonic GM2  (57) embryonic Kc167  (66) embryonic S1  (77) embryonic S3  (66) leg disc CME L1  (65) wing disc CME-W2  (44) wing disc ML-DmD8  (91) wing disc ML-DmD9  (121) wing disc ML-DmD16-c3  (103) wing disc ML-DmD21  (60) wing disc ML-DmD32  (184) haltere disc ML-DmD17-c3  (93) eye-antennal disc ML-DmD11  (102) antennal disc ML-DmD20-c5  (77) mixed discs ML-DmD4-c1  (101) CNS ML-DmBG1-c1  (80) CNS ML-DmBG2-c2  (38) tumorous blood cells mbn2  (52) ovary fGS/OSS  (112) ovary OSC  (160) ovary OSS  (95) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    91 Schneider line 2 Sg4    33 embryonic 1182-4H  (123) embryonic GM2    57 embryonic Kc167    66 embryonic S1    77 embryonic S3    66 leg disc CME L1    65 wing disc CME-W2    44 wing disc ML-DmD8    91 wing disc ML-DmD9  (121) wing disc ML-DmD16-c3  103 wing disc ML-DmD21    60 wing disc ML-DmD32  (184) haltere disc ML-DmD17-c3    93 eye-antennal disc ML-DmD11  102 antennal disc ML-DmD20-c5    77 mixed discs ML-DmD4-c1  101 CNS ML-DmBG1-c1    80 CNS ML-DmBG2-c2    38 tumorous blood cells mbn2    52 ovary fGS/OSS  (112) ovary OSC  (160) ovary OSS    95 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    91 Schneider line 2 Sg4    33 embryonic 1182-4H    123 embryonic GM2    57 embryonic Kc167    66 embryonic S1    77 embryonic S3    66 leg disc CME L1    65 wing disc CME-W2    44 wing disc ML-DmD8    91 wing disc ML-DmD9    121 wing disc ML-DmD16-c3    103 wing disc ML-DmD21    60 wing disc ML-DmD32    184 haltere disc ML-DmD17-c3    93 eye-antennal disc ML-DmD11    102 antennal disc ML-DmD20-c5    77 mixed discs ML-DmD4-c1    101 CNS ML-DmBG1-c1    80 CNS ML-DmBG2-c2    38 tumorous blood cells mbn2    52 ovary fGS/OSS    112 ovary OSC    160 ovary OSS    95 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    91 Schneider line 2 Sg4    33 embryonic 1182-4H    123 embryonic GM2    57 embryonic Kc167    66 embryonic S1    77 embryonic S3    66 leg disc CME L1    65 wing disc CME-W2    44 wing disc ML-DmD8    91 wing disc ML-DmD9    121 wing disc ML-DmD16-c3    103 wing disc ML-DmD21    60 wing disc ML-DmD32    184 haltere disc ML-DmD17-c3    93 eye-antennal disc ML-DmD11    102 antennal disc ML-DmD20-c5    77 mixed discs ML-DmD4-c1    101 CNS ML-DmBG1-c1    80 CNS ML-DmBG2-c2    38 tumorous blood cells mbn2    52 ovary fGS/OSS    112 ovary OSC    160 ovary OSS    95 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (91) Schneider line 2 Sg4  (33) embryonic 1182-4H  (123) embryonic GM2  (57) embryonic Kc167  (66) embryonic S1  (77) embryonic S3  (66) leg disc CME L1  (65) wing disc CME-W2  (44) wing disc ML-DmD8  (91) wing disc ML-DmD9  (121) wing disc ML-DmD16-c3  (103) wing disc ML-DmD21  (60) wing disc ML-DmD32  (184) haltere disc ML-DmD17-c3  (93) eye-antennal disc ML-DmD11  (102) antennal disc ML-DmD20-c5  (77) mixed discs ML-DmD4-c1  (101) CNS ML-DmBG1-c1  (80) CNS ML-DmBG2-c2  (38) tumorous blood cells mbn2  (52) ovary fGS/OSS  (112) ovary OSC  (160) ovary OSS  (95) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    91 Schneider line 2 Sg4    33 embryonic 1182-4H  123 embryonic GM2    57 embryonic Kc167    66 embryonic S1    77 embryonic S3    66 leg disc CME L1    65 wing disc CME-W2    44 wing disc ML-DmD8    91 wing disc ML-DmD9  121 wing disc ML-DmD16-c3  103 wing disc ML-DmD21    60 wing disc ML-DmD32  (184) haltere disc ML-DmD17-c3    93 eye-antennal disc ML-DmD11  102 antennal disc ML-DmD20-c5    77 mixed discs ML-DmD4-c1  101 CNS ML-DmBG1-c1    80 CNS ML-DmBG2-c2    38 tumorous blood cells mbn2    52 ovary fGS/OSS  112 ovary OSC  (160) ovary OSS    95 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    91 Schneider line 2 Sg4    33 embryonic 1182-4H    123 embryonic GM2    57 embryonic Kc167    66 embryonic S1    77 embryonic S3    66 leg disc CME L1    65 wing disc CME-W2    44 wing disc ML-DmD8    91 wing disc ML-DmD9    121 wing disc ML-DmD16-c3    103 wing disc ML-DmD21    60 wing disc ML-DmD32    184 haltere disc ML-DmD17-c3    93 eye-antennal disc ML-DmD11    102 antennal disc ML-DmD20-c5    77 mixed discs ML-DmD4-c1    101 CNS ML-DmBG1-c1    80 CNS ML-DmBG2-c2    38 tumorous blood cells mbn2    52 ovary fGS/OSS    112 ovary OSC    160 ovary OSS    95 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    96 cold shock, 4-day adult    73 heat shock, 4-day adult    218 Cadmium 50 mM 6 hrs, larvae L3    347 Cadmium 50 mM 12 hrs, larvae L3    300 Cadmium 50 mM 48 hrs, 4-day adult    261 Cadmium 100 mM 48 hrs, 4-day adult    136 Copper 0.5 mM 12 hrs, larvae L3    338 Copper 15 mM 48 hrs, 4-day adult    125 Zinc 5 mM 12 hrs, larvae L3    274 Zinc 4.5 mM 48 hrs, 4-day adult    107 Ethanol 2.5% 3 hrs, larvae L3    77 Ethanol 5% 3 hrs, larvae L3    325 Ethanol 10% 3 hrs, larvae L3    371 Caffeine 1.5 mg/ml 4 hrs, larvae L3    343 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    138 Caffeine 25 mg/ml 48 hrs, 4-day adult    110 Paraquat 5 mM 48 hrs, 4-day adult    118 Paraquat 10 mM 48 hrs, 4-day adult    73 Rotenone 2 μg 12 hrs, larvae L3    331 Rotenone 8 μg 12 hrs, larvae L3    387 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (96) cold shock, 4-day adult  (73) heat shock, 4-day adult  (218) Cadmium 50 mM 6 hrs, larvae L3  (347) Cadmium 50 mM 12 hrs, larvae L3  (300) Cadmium 50 mM 48 hrs, 4-day adult  (261) Cadmium 100 mM 48 hrs, 4-day adult  (136) Copper 0.5 mM 12 hrs, larvae L3  (338) Copper 15 mM 48 hrs, 4-day adult  (125) Zinc 5 mM 12 hrs, larvae L3  (274) Zinc 4.5 mM 48 hrs, 4-day adult  (107) Ethanol 2.5% 3 hrs, larvae L3  (77) Ethanol 5% 3 hrs, larvae L3  (325) Ethanol 10% 3 hrs, larvae L3  (371) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (343) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (138) Caffeine 25 mg/ml 48 hrs, 4-day adult  (110) Paraquat 5 mM 48 hrs, 4-day adult  (118) Paraquat 10 mM 48 hrs, 4-day adult  (73) Rotenone 2 μg 12 hrs, larvae L3  (331) Rotenone 8 μg 12 hrs, larvae L3  (387) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    96 cold shock, 4-day adult    73 heat shock, 4-day adult  (218) Cadmium 50 mM 6 hrs, larvae L3  (347) Cadmium 50 mM 12 hrs, larvae L3  (300) Cadmium 50 mM 48 hrs, 4-day adult  (261) Cadmium 100 mM 48 hrs, 4-day adult  (136) Copper 0.5 mM 12 hrs, larvae L3  (338) Copper 15 mM 48 hrs, 4-day adult  (125) Zinc 5 mM 12 hrs, larvae L3  (274) Zinc 4.5 mM 48 hrs, 4-day adult  107 Ethanol 2.5% 3 hrs, larvae L3    77 Ethanol 5% 3 hrs, larvae L3  (325) Ethanol 10% 3 hrs, larvae L3  (371) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (343) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (138) Caffeine 25 mg/ml 48 hrs, 4-day adult  (110) Paraquat 5 mM 48 hrs, 4-day adult  (118) Paraquat 10 mM 48 hrs, 4-day adult    73 Rotenone 2 μg 12 hrs, larvae L3  (331) Rotenone 8 μg 12 hrs, larvae L3  (387) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    96 cold shock, 4-day adult    73 heat shock, 4-day adult    218 Cadmium 50 mM 6 hrs, larvae L3    347 Cadmium 50 mM 12 hrs, larvae L3    300 Cadmium 50 mM 48 hrs, 4-day adult    261 Cadmium 100 mM 48 hrs, 4-day adult    136 Copper 0.5 mM 12 hrs, larvae L3    338 Copper 15 mM 48 hrs, 4-day adult    125 Zinc 5 mM 12 hrs, larvae L3    274 Zinc 4.5 mM 48 hrs, 4-day adult    107 Ethanol 2.5% 3 hrs, larvae L3    77 Ethanol 5% 3 hrs, larvae L3    325 Ethanol 10% 3 hrs, larvae L3    371 Caffeine 1.5 mg/ml 4 hrs, larvae L3    343 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    138 Caffeine 25 mg/ml 48 hrs, 4-day adult    110 Paraquat 5 mM 48 hrs, 4-day adult    118 Paraquat 10 mM 48 hrs, 4-day adult    73 Rotenone 2 μg 12 hrs, larvae L3    331 Rotenone 8 μg 12 hrs, larvae L3    387 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    96 cold shock, 4-day adult    73 heat shock, 4-day adult    218 Cadmium 50 mM 6 hrs, larvae L3    347 Cadmium 50 mM 12 hrs, larvae L3    300 Cadmium 50 mM 48 hrs, 4-day adult    261 Cadmium 100 mM 48 hrs, 4-day adult    136 Copper 0.5 mM 12 hrs, larvae L3    338 Copper 15 mM 48 hrs, 4-day adult    125 Zinc 5 mM 12 hrs, larvae L3    274 Zinc 4.5 mM 48 hrs, 4-day adult    107 Ethanol 2.5% 3 hrs, larvae L3    77 Ethanol 5% 3 hrs, larvae L3    325 Ethanol 10% 3 hrs, larvae L3    371 Caffeine 1.5 mg/ml 4 hrs, larvae L3    343 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    138 Caffeine 25 mg/ml 48 hrs, 4-day adult    110 Paraquat 5 mM 48 hrs, 4-day adult    118 Paraquat 10 mM 48 hrs, 4-day adult    73 Rotenone 2 μg 12 hrs, larvae L3    331 Rotenone 8 μg 12 hrs, larvae L3    387 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (96) cold shock, 4-day adult  (73) heat shock, 4-day adult  (218) Cadmium 50 mM 6 hrs, larvae L3  (347) Cadmium 50 mM 12 hrs, larvae L3  (300) Cadmium 50 mM 48 hrs, 4-day adult  (261) Cadmium 100 mM 48 hrs, 4-day adult  (136) Copper 0.5 mM 12 hrs, larvae L3  (338) Copper 15 mM 48 hrs, 4-day adult  (125) Zinc 5 mM 12 hrs, larvae L3  (274) Zinc 4.5 mM 48 hrs, 4-day adult  (107) Ethanol 2.5% 3 hrs, larvae L3  (77) Ethanol 5% 3 hrs, larvae L3  (325) Ethanol 10% 3 hrs, larvae L3  (371) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (343) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (138) Caffeine 25 mg/ml 48 hrs, 4-day adult  (110) Paraquat 5 mM 48 hrs, 4-day adult  (118) Paraquat 10 mM 48 hrs, 4-day adult  (73) Rotenone 2 μg 12 hrs, larvae L3  (331) Rotenone 8 μg 12 hrs, larvae L3  (387) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    96 cold shock, 4-day adult    73 heat shock, 4-day adult  (218) Cadmium 50 mM 6 hrs, larvae L3  (347) Cadmium 50 mM 12 hrs, larvae L3  (300) Cadmium 50 mM 48 hrs, 4-day adult  (261) Cadmium 100 mM 48 hrs, 4-day adult  136 Copper 0.5 mM 12 hrs, larvae L3  (338) Copper 15 mM 48 hrs, 4-day adult  125 Zinc 5 mM 12 hrs, larvae L3  (274) Zinc 4.5 mM 48 hrs, 4-day adult  107 Ethanol 2.5% 3 hrs, larvae L3    77 Ethanol 5% 3 hrs, larvae L3  (325) Ethanol 10% 3 hrs, larvae L3  (371) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (343) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  138 Caffeine 25 mg/ml 48 hrs, 4-day adult  110 Paraquat 5 mM 48 hrs, 4-day adult  118 Paraquat 10 mM 48 hrs, 4-day adult    73 Rotenone 2 μg 12 hrs, larvae L3  (331) Rotenone 8 μg 12 hrs, larvae L3  (387) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    96 cold shock, 4-day adult    73 heat shock, 4-day adult    218 Cadmium 50 mM 6 hrs, larvae L3    347 Cadmium 50 mM 12 hrs, larvae L3    300 Cadmium 50 mM 48 hrs, 4-day adult    261 Cadmium 100 mM 48 hrs, 4-day adult    136 Copper 0.5 mM 12 hrs, larvae L3    338 Copper 15 mM 48 hrs, 4-day adult    125 Zinc 5 mM 12 hrs, larvae L3    274 Zinc 4.5 mM 48 hrs, 4-day adult    107 Ethanol 2.5% 3 hrs, larvae L3    77 Ethanol 5% 3 hrs, larvae L3    325 Ethanol 10% 3 hrs, larvae L3    371 Caffeine 1.5 mg/ml 4 hrs, larvae L3    343 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    138 Caffeine 25 mg/ml 48 hrs, 4-day adult    110 Paraquat 5 mM 48 hrs, 4-day adult    118 Paraquat 10 mM 48 hrs, 4-day adult    73 Rotenone 2 μg 12 hrs, larvae L3    331 Rotenone 8 μg 12 hrs, larvae L3    387 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_18 mE1_20_mRNA_expression_cluster_10
External Data & Images
Linkouts	BDGP expression data • GH09289 LD37158 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003721 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4898-RE;CG4898-RC;CG4898-RB;CG4898-RA;HDC13727;S.C3R001542
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal Tm1CC00578 Tm1CC01710 lethal, with Scer\GAL4Mef2.PR Tm1GD10529 lethal (with Df(3R)sbd26) Tm1S130510 lethal | embryonic stage | recessive Tm1G5 Tm1S130510 Tm1Thor-GFP lethal | larval stage | recessive Tm102299 lethal | recessive Tm102299 Tm109965 Tm110617 Tm1el3 Tm1el4 Tm1er4 Tm1PBss Tm1s2958 Tm1S130510 partially lethal - majority die | pupal stage, with Scer\GAL4pnr-MD237 Tm1GD10529 viable Tm1Wee-P27 Sterility Allele grandchildless Tm1eg9 sterile | germline clone | maternal effect Tm1el3 Tm1el4 Tm1er4 Other Phenotypes Allele behavior defective | recessive Tm102299 neuroanatomy defective Tm102299 Tm1el4 Tm1S130510 neuroanatomy defective (with Tm102299) Tm1S130510 neuroanatomy defective (with Tm1el4) Tm1S130510 neuroanatomy defective (with Tm1S130510) Tm102299 Tm1el4 visible, with Scer\GAL4pnr-MD237 Tm1GD10529 Phenotype manifest in Allele border follicle cell Tm1ZCL0722 Tm102299 Tm1Su(flw)4 border follicle cell | somatic clone Tm1ZCL0722 Tm1Su(flw)4 chromosome | embryonic stage Tm1Thor-GFP dendritic arborising neuron & dendrite Tm1S130510 dendritic arborising neuron & dendrite (with Tm1el4) Tm1S130510 dendritic arborising neuron & dendrite (with Tm1S130510) Tm1el4 dorsal multidendritic neuron ddaC & dendrite | somatic clone Tm1S130510 dorsal multidendritic neuron ddaE & dendrite Tm102299 Tm1S130510 Tm1el4 dorsal multidendritic neuron ddaE & dendrite (with Tm102299) Tm1S130510 dorsal multidendritic neuron ddaE & dendrite (with Tm1el4) Tm1S130510 dorsal multidendritic neuron ddaE & dendrite (with Tm1S130510) Tm102299 Tm1el4 embryonic/larval pharynx | embryonic stage Tm102299 germline cell Tm1eg20 Tm1eg9 germline cell | maternal effect Tm1eg20 Tm1eg9 Tm1gs1 mesothoracic tergum, with Scer\GAL4pnr-MD237 Tm1GD10529 nucleus | embryonic stage 4 Tm1G5 pole cell Tm102299
Classical Alleles ( 53 )
For All Classical Alleles Show
Allele of Tm1 Class Mutagen Stocks Known lesion Tm102299 loss of function allele P-element activity 1 Yes Tm15-HA-1053 1 -- Tm15-HA-1539 1 -- Tm1c04719 piggyBac transposase 1 -- Tm1CB-0741-3 1 -- Tm1CB-0744-3 1 -- Tm1d00962 P-element activity 1 -- Tm1e01025 piggyBac transposase 1 -- Tm1e01164 piggyBac transposase 1 -- Tm1e03398 piggyBac transposase 1 -- Tm1e04059 1 -- Tm1EY12089 P-element activity 1 -- Tm1f00374 piggyBac transposase 1 -- Tm1f01108 1 -- Tm1L7160c P-element activity 1 -- Tm1NP0223 1 -- Tm1NP3018 1 -- Tm1Su(flw)4 ethyl methanesulfonate 1 -- Tm1UM-8332-3 1 -- Tm109965 P-element activity 0 -- Tm110617 P-element activity 0 -- Tm1CC00578 P-element activity 0 Yes Tm1CC01710 P-element activity 0 Yes Tm1CC02057 P-element activity 0 -- Tm1CPTI000760 piggyBac transposase 0 Yes Tm1CPTI002243 piggyBac transposase 0 Yes Tm1e03393 piggyBac transposase 0 -- Tm1eg20 0 Yes Tm1eg9 P-element activity 0 Yes Tm1el3 P-element activity 0 -- Tm1el4 P-element activity 0 -- Tm1er4 P-element activity 0 -- Tm1ew1 P-element activity 0 -- Tm1F 0 -- Tm1G5 P-element activity 0 Yes Tm1gs1 P-element activity 0 Yes Tm1gs1ex1 0 Yes Tm1gs2 P-element activity 0 Yes Tm1gs3 P-element activity 0 Yes Tm1j13E8 P-element activity 0 -- Tm1L4120a P-element activity 0 -- Tm1L7042 P-element activity 0 -- Tm1M 0 -- Tm1PBss piggyBac transposase 0 Yes Tm1S130510 Delta2-3 P-element activity 0 -- Tm1s2047 P-element activity 0 -- Tm1s2958 P-element activity 0 -- Tm1s3601 P-element activity 0 -- Tm1S 0 -- Tm1Thor-GFP 0 -- Tm1unspecified 0 -- Tm1Wee-P27 0 Yes Tm1ZCL0722 0 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Tm1 Class Mutagen Stocks Known lesion Tm1GD10529 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Tm1GL01518 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Tm1HMS01676 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Not disrupted in	Df(3R)sbd105 (Spradling et al., 1999)
Disrupted in	Df(3R)ea (Tetzlaff et al., 1996) Df(3R)ea-5022rx1 (Erdelyi et al., 1995) Df(3R)sbd26 (Deak et al., 1997)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data reporter construct P{-22-1367HSP} No P{-22PI} No P{-243PI} No P{-1200LACcTm-3'} No P{-1200LAChsp70-3'} No P{-1200LACSV40-3'} No P{-1400P} No P{-1400PI} No P{-1400PIΔ1.2} No P{-1400PIΔBglII} No P{+167-320HSP} No P{+167-621-1400PIΔ1.2} No P{+167-621HSP} No P{+167-671-1400P} No P{+167-1367HSP} No P{+310-471HSP} No P{+454-621HSP} No P{Tm1-lacZ.URE} No UAS construct P{GD10529} NA P{TRiP.GL01518} NA P{TRiP.HMS01676} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{PTT-GC}Tm1CC00578 NA P{PTT-GC}Tm1CC01710 NA P{PTT-GC}Tm1G5 NA P{PTT-GC}YC0071 NA P{PTT-un1}Tm1CC02057 NA P{PTT-un1}Tm1Thor-GFP NA P{RS3}Tm1CB-0741-3 NA P{RS3}Tm1CB-0744-3 NA P{RS3}Tm1UM-8332-3 NA P{RS5}Tm15-HA-1053 NA P{RS5}Tm15-HA-1539 NA P{Wee-P.ph0}Tm1Wee-P27 NA PBac{602.P.SVS-1}Tm1CPTI000760 NA PBac{754.P.FSVS-0}Tm1CPTI002243 NA PBac{PB}Tm1c04719 NA PBac{PBss}Tm1PBss NA PBac{RB}Tm1e01025 NA PBac{RB}Tm1e01164 NA PBac{RB}Tm1e03393 NA PBac{RB}Tm1e03398 NA PBac{RB}Tm1e04059 NA PBac{WH}Tm1f00374 NA PBac{WH}Tm1f01108 NA insertion of enhancer trap binary system P{GawB}Tm1C817 No P{GawB}Tm1NP0223 No P{GawB}Tm1NP3018 No insertion of mobile activating element P{EPgy2}Tm1EY12089 NA P{XP}Tm1d00962 NA insertion of enhancer trap P{lacW}Tm1gs1 No P{lacW}Tm1gs2 No P{lacW}Tm1gs3 No P{lacW}Tm1j13E8 No P{lacW}Tm1L4120a No P{lacW}Tm1L7042 No P{lacW}Tm1L7160c No P{lacW}Tm1s2047 No P{lacW}Tm1s2958 No P{lacW}Tm1s3601 No P{lacW}Tm1S130510 No P{PZ}Tm102299 No P{PZ}Tm109965 No P{PZ}Tm110617 No
Gene Ontology: Function, Process & Cellular Component ( 13 unique terms )
Terms Based on Experimental Evidence ( 8 terms )
Molecular Function
CV term Evidence References
actin filament binding inferred from direct assay (Kim et al., 2011)
Biological Process
CV term Evidence References
dendrite morphogenesis inferred from mutant phenotype (Li and Gao, 2003) pole plasm oskar mRNA localization inferred from mutant phenotype (Erdelyi et al., 1995) regulation of lamellipodium assembly inferred from mutant phenotype (Iwasa and Mullins, 2007)
Cellular Component
CV term Evidence References
colocalizes_with filamentous actin inferred from direct assay (Texada et al., 2011) investment cone inferred from direct assay (Texada et al., 2011) sarcomere inferred from direct assay (Hudson et al., 2008) colocalizes_with sarcoplasmic reticulum inferred from direct assay (Texada et al., 2011)
Terms Based on Predictions or Assertions ( 7 terms )
Molecular Function
CV term Evidence References
actin binding inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000) traceable author statement (Johnstone and Lasko, 2001)
Biological Process
CV term Evidence References
dendrite morphogenesis traceable author statement (Grueber and Jan, 2004) muscle contraction non-traceable author statement (Tekotte and Davis, 2002) oogenesis traceable author statement (Wylie, 1999) pole plasm assembly non-traceable author statement (Williamson and Lehmann, 1996) pole plasm oskar mRNA localization traceable author statement (Johnstone and Lasko, 2001, Tekotte and Davis, 2002)
Cellular Component
CV term Evidence References
muscle thin filament tropomyosin non-traceable author statement (Swiss-Prot Project Members, 1988.1.1, Swiss-Prot Project Members, 1996.2.1)
Sequence Ontology: Class of Gene
	gene_with_edited_transcript (Graveley et al., 2011) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Tm1 - 128up anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - AP-1-2β anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - ATPsyn-γ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - Adk2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - Ald anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - Atf-2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - B52 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - BHD anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - CG10184 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - CG10581 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - CG10641 experimental knowledge based (Guruharsha et al., 2011) Tm1 - CG11163 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - CG11188 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - CG11200 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - CG11236 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - CG11248 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - CG11436 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - CG11459 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) Tm1 - CG11808 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - CG11857 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - CG12395 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - CG12428 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - CG12869 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - CG13144 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - CG1354 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - CG13822 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - CG14207 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - CG14259 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - CG14454 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - CG14823 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - CG15643 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - CG1637 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - CG16812 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - CG17565 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - CG1785 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - CG1902 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - CG2887 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - CG2909 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - CG3009 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - CG30184 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - CG30393 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - CG3085 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - CG3106 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - CG31200 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - CG31248 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - CG31251 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - CG31637 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - CG32445 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - CG32488 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - CG32512 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - CG33107 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - CG33145 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - CG3362 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - CG33695 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - CG3501 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - CG3548 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - CG4091 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - CG4199 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - CG42258 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - CG4455 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - CG4502 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - CG4565 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - CG4645 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - CG4973 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - CG5045 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - CG5445 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - CG6304 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - CG6412 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - CG6453 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - CG6506 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - CG6712 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - CG6724 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - CG6937 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - CG7102 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - CG7164 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - CG7275 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - CG7737 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - CG7742 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - CG8207 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - CG8336 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - CG8441 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - CG8801 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - CG8929 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - CG8939 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - CG8944 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - CG9391 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - Cdc5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - CkIIα anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - Cpr100A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - CtBP anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - CycK anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - Cyp4d2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - DNaseII anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - Dat experimental knowledge based (Guruharsha et al., 2011) Tm1 - Dd anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - Dgk anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - Dlic anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - E(spl)mγ-HLH anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - Elongin-B anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - Fbp2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - Fibp anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Tm1 - GABPI anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - Ggt-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - HIP-R anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - Hsp60C anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - Iap2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - IntS12 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - Ipk1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - Irp-1A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - JhI-21 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - Khc anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - Kr-h1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - Lac anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - Lip4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - Lrr47 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - Lst8 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - Mad anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - Mis12 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - Mlc-c experimental knowledge based (Guruharsha et al., 2011) Tm1 - Nmdar1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - P32 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - P5cr anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - PCID2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - PhKγ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - Pli anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - Pof anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - Ptp61F anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - Rab10 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - Rab2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - RagC-D anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - Rbf anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - Rcd-1r anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - RpL24-like anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - RpL7-like anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - SC35 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - Sk1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - Sk2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - Skp2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - SmD3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - Sox21a anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - Spf45 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - Sry-β anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - TH1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - Tango11 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - VhaSFD anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - ana2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - aph-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - bonsai anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - brk anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - debcl anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - fs(1)K10 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - ftz anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - gk anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - hbn anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - kay anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - lva anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - mTerf5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - mbm anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - ncm anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - nct anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - ninaE anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - noi anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - nop5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - p38c anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - pav anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - pic anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - porin anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - rap anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - rdhB anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - scpr-B anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - skpA anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - slmb anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - ste24a anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - sxe2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - tud anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - v anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - velo anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - viaf anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - wcd anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tm1 - zip experimental knowledge based (Guruharsha et al., 2011)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Tm1 allele Gene References Tm102299 br (Ward et al., 2003) flw (Vereshchagina et al., 2004) Tm1eg9 br (Ward et al., 2003) E(To)1 (Jankovics et al., 2001) E(To)4 (Jankovics et al., 2001) E(To)6 (Jankovics et al., 2001) E(To)10 (Jankovics et al., 2001) E(To)12 (Jankovics et al., 2001) E(To)13 (Jankovics et al., 2001) osk (Jankovics et al., 2001) Rab11 (Jankovics et al., 2001) vas (Jankovics et al., 2001) zip (Halsell and Kiehart, 1998) Tm1eg20 E(To)1 (Jankovics et al., 2001) E(To)4 (Jankovics et al., 2001) E(To)6 (Jankovics et al., 2001) E(To)10 (Jankovics et al., 2001) E(To)12 (Jankovics et al., 2001) E(To)13 (Jankovics et al., 2001) osk (Jankovics et al., 2001) Rab11 (Jankovics et al., 2001) vas (Jankovics et al., 2001) Tm1el4 osk (Jankovics et al., 2001) stan (Li and Gao, 2003) Tm1er4 zip (Halsell and Kiehart, 1998) Tm1S130510 stan (Li and Gao, 2003) Tm1Su(flw)4 flw (Vereshchagina et al., 2004) unspecified bs (Ward et al., 2003) E(To)5 (Jankovics et al., 2001) E(To)8 (Jankovics et al., 2001) E(To)9 (Jankovics et al., 2001) mago (Jankovics et al., 2001)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 66916 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0003721 DroID - A comprehensive database of gene and protein interactions. • FBgn0003721 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41852
Orthologs
OrthoDB Orthologs (58) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG61G3Q0 Dipteran inclusive ortholog search EOG654971 Insect inclusive ortholog search EOG6RN94S Arthropod inclusive ortholog search EOG6B5MMG Metazoa inclusive ortholog search EOG622PC1
Orthologs in Drosophila Species (EOG61G3Q0)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Tm1     Drosophila simulans   Dsim\GD19006 Y   Drosophila sechellia   Dsec\GM24215 Y   Drosophila erecta   Dere\GG16908 Y   Drosophila yakuba   Dyak\Tm1 Y   Drosophila ananassae   Dana\GF11453 Y   Drosophila pseudoobscura pseudoobscura   Dpse\Tm1 Y   Drosophila persimilis   Dper\GL12543 Y   Drosophila willistoni   Dwil\GK13796 Y   Drosophila virilis   Dvir\GJ23210 Y   Drosophila mojavensis   Dmoj\GI22927 Y   Drosophila grimshawi   Dgri\GH18857 Y
Orthologs in non-Drosophila Dipterans (EOG654971)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL002761   Anopheles gambiae Malaria mosquito  Agam\AGAP001797   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ013364
Orthologs in non-Dipteran Insects (EOG6RN94S)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC408414 Y Apis mellifera Western honey bee  Amel\LOC413205 Y Apis mellifera Western honey bee  Amel\GB55328 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG005598 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG005596 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG013135 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH21975 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH20318 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH23978 Y Atta cephalotes Leafcutter ant  Acep\ACEP11853 Y Atta cephalotes Leafcutter ant  Acep\ACEP27471 Y Atta cephalotes Leafcutter ant  Acep\ACEP27465 Y Atta cephalotes Leafcutter ant  Acep\ACEP14406 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO18223 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO22467 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO23283 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL21496 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL16051 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL21839 Y Linepithema humile Argentine ant  Lhum\LH20835 Y Linepithema humile Argentine ant  Lhum\LH24164 Y Linepithema humile Argentine ant  Lhum\LH12775 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB15314 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB22668 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB20076 Y Solenopsis invicta Red fire ant  Sinv\SINV20594 Y Solenopsis invicta Red fire ant  Sinv\SINV13558 Y Solenopsis invicta Red fire ant  Sinv\SINV17330 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI000969 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI56897 Y Bombyx mori Silkmoth  Bmor\BGIBMGA001585 Y Bombyx mori Silkmoth  Bmor\BGIBMGA001587 Y Bombyx mori Silkmoth  Bmor\Bmo.13464 Y Pediculus humanus Human body louse  Phum\PHUM400120 Y Pediculus humanus Human body louse  Phum\PHUM400340 Y Tribolium castaneum Red flour beetle  Tcas\TC011461 Y Tribolium castaneum Red flour beetle  Tcas\TC011019 Y
Orthologs in non-Insect Arthropods (EOG6B5MMG)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\SCGB1A1 Y Ixodes scapularis Deer tick  Isca\ISCW008202 Y
Orthologs in non-Arthropod Metazoa (EOG622PC1)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\lev-11 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_000128gn Y Xenopus tropicalis Western clawed frog  Xtro\tpm2 Y Xenopus tropicalis Western clawed frog  Xtro\tpm3 Y
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD19006 Drosophila sechellia Dsec\GM24215 Drosophila erecta Dere\GG16908 Drosophila yakuba Dyak\Tm1 Drosophila ananassae Dana\GF11453 Drosophila pseudoobscura pseudoobscura Dpse\Tm1 Drosophila persimilis Dper\GL12543 Drosophila willistoni Dwil\GK13796 Drosophila virilis Dvir\GJ23210 Drosophila mojavensis Dmoj\GI22927 Drosophila grimshawi Dgri\GH18857
Stocks & Reagents
Stocks Listed in FlyBase ( 22 )
Harvard	- P{XP}Tm1d00962 - PBac{PB}Tm1c04719 - PBac{RB}Tm1e01025 - PBac{RB}Tm1e01164 - PBac{RB}Tm1e03398 - PBac{RB}Tm1e04059 - PBac{WH}Tm1f00374 - PBac{WH}Tm1f01108
Kyoto	123304 w1118; P{RS3}Tm1CB-0741-3 123306 w1118; P{RS3}Tm1CB-0744-3 124484 w1118; P{RS3}Tm1UM-8332-3
VDRC	v34119 w1118; P{GD10529}v34119
	More stocks available...
Genomic Clones ( 1 )
	BACR13A02 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 495 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH09289 IP16008 LD11194 LD37158 RE08101 RE21974 SD07763 SD21996
Other clones	DPiM_GH09289 DPiM_LD37158 FI17820 MIP08601 yak-em_Tm1
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT08341 GH12643 GH25315 GH27619 GH27881 GM05152 GM08931 GM16294 HL01822 LD02774 LD05388 LD05487 LD06323 LD06401 LD06778 LD07357 LD10395 LD13487 LD15911 LD16380 LD17485 LD20302 LD28639 LD31502 LD31902 LD33688 LD39982 LD42336 LD43907 LD45712 LD45736 LP02563 LP08189 LP08639 LP10050 LP11686 LP12458 RE07743 RE09494 RE10289 RE11475 RE12293 RE15640 RE15748 RE15889 RE17880 RE18413 RE19869 RE20265 RE20952 RE22974 RE23036 RE23411 RE23911 RE24357 RE28942 RE29344 RE29355 RE31848 RE32148 RE32450 RE33016 RE33081 RE34246 RE34604 RE34687 RE35391 RE35967 RE36043 RE40491 RE40678 RE40692 RE40701 RE41420 RE41522 RE41784 RE42303 RE42734 RE42937 RE43241 RE43732 RE43768 RE44587 RE44621 RE45435 RE45615 RE46026 RE46902 RE46966 RE46968 RE46970 RE46979 RE47552 RE48961 RE48974 RE49243 RE49434 RE49452 RE50861 RE50874 RE51143 RE51334 RE51352 RE51879 RE51880 RE52002 RE52277 RE52512 RE52818 RE53001 RE53501 RE53601 RE54244 RE54363 RE54676 RE55009 RE55019 RE55263 RE55822 RE56090 RE56193 RE56216 RE56543 RE57273 RE57347 RE57442 RE57483 RE57616 RE57852 RE57906 RE58136 RE58555 RE59762 RE60976 RE61163 RE61277 RE62428 RE62576 RE62621 RE63160 RE63370 RE63968 RE64105 RE65022 RE66234 RE67062 RE68224 RE69644 RE70544 RE70556 RE70986 RE72310 RE72676 RE72682 RE72872 RE72909 RE73351 RE74426 RE74930 RH10521 RH15938 RH17579 RH69755 SD03214 SD05773 SD07075 SD24337
Other clones	783 5134 5223 8027 8061 9568 10694 11164 14294 16181 18983 19324 32180 38150 45392 46240 56398 56749 57419 57535 59057 59270 61770 63121 67172 67786 70353 74499 74556 74639 74999 75503 101038 102498 104097 107678.1 117702 118962 120014 121002 122423 122983 147061 157914 158260 162419 166129 174389 174439 190265 191002 214253.42 214255.42 214435.37 214435.38 214469.54 214499.61 214501.34 214543.61 274689 277186 281180 282211 283275 561978 562006 bs08b11 CK01.10A.E5 CK01.15A.D9 CK01.16D.C12 CK01.17D.F5 CK01.17D.F7 CK01.23A.E7 CK01.29A.G3 CK01.31C.C4 CK01.34A.F11 CK01.35D.G10 CK01.49B.G7 CK01.49D.C6 CK01.51B.G9 CK01.78C.C3 CK01.81D.F4 CK01.83A.G9 CK01.86A.G7 CK01.86C.A10 CK01.88D.H5 CK01.99C.F5 CK01.101A.F9 CK01.103C.C10 CK01.109C.A6 CK01.110B.A4 CK01.112D.G12 CK01.124A.B6 CK01.132D.D1 CK01.169D.A4 Dmel_neb_013289_0323_3661 Dmel_neb_014744_0575_1149 EC14262 EC33284 EK010948 EK017223 EK017224 EK020802 EK021113 EK039447 EK041343 EK041428 EK043125 EK061110 EK064341 EK066227 EK068028 EK068235 EK069831 EK079441 EK084323 EK086843 EK092604 EK101213 EK104134 EK106032 EK106059 EK107839 EK108439 EK110517 EK110864 EK116631 EK121136 EK123934 EK124351 EK127058 EK132264 EK142460 EK150532 EK150604 EK161219 EK168757 EK177821 EK177930 EK183342 EK185131 EK189049 EK195339 EK195729 EK198030 EK204716 EK207011 EK211705 EK223754 EK225625 EK227534 EK233346 EK237056 EK238101 EK238639 EK240013 EK240945 EK242213 EK246903 EK249544 EK249801 EK260843 EK275846 EK292328 EK292955 EK302525 EK302608 EK303830 EK306262 EK307903 EK308014 EN11901 EN13460 EN13533 EP03460 EP03747 EP04716 EP04913 EP08454 EP10454 EP10908 EP21655 FGC028D12 FGC029D12 FGM227B03 IP06122 IP06222 IP06322 IP16108 IP16116 IP16208 IP16308 LD01160 LD02775 LD10214 LD14729 LD20721 LD21516 LD27515 LD27948 LD27959 LD30601 LD40071 LP01301 LP22906 RC0-DP0003-140700-011-C12 RE02492 RE02820 RE02828 RE03107 RE03742 RE03928 RE04144 RE04232 RE04695 RE04944 RE05104 RE06061 RE06321 RE07315 RE07979 RE08447 RE08794 RE08918 RE09038 RE09431 RE09866 RE10420 RE10647 RE11529 RE12585 RE12915 RE13207 RE13353 RE13679 RE14795 RE15503 RE15965 RE16201 RE16660 RE16669 RE16972 RE16982 RE17583 RE18593 RE19190 RE19484 RE19691 RE19839 RE19858 RE20838 RE21408 RE21449 RE21636 RE23149 RE23810 RE24019 RE24075 RE24706 RE24755 RE25630 RE26715 RE26874 RE27352 RE27954 RE29562 RE30074 RE35873 RE43722 RE43744 RE43793 RE52675 RE56006 RE64346 RE65247 RE65976 RE69868 RE70681 RH01476 RH02280 RH02283 RH02288 RH02730 RH03485 RH06688 RH08068 RH08853 RH09908 RH10689 RH10931 RH11529 RH13210 RH13823 RH14169 RH14389 RH14625 RH14817 RH15341 RH16036 RH16879 RH18605 RH18643 RH20817 RH21934 RH24110 RH28302 RH48317 RH50093 RH62968 RH64475 RH69916 RP004027456 RP004255756 RP004376011 UUGC0688
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0003721 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41852
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Tm1 CG4898 (Zheng, 1999.11)
Source for database merge of	Source for merge of: Tm1 BcDNA:GH09289 (FlyBase, 1996-) Source for merge of: Tm1 BcDNA:LD37158 (FlyBase, 1996-) Source for merge of: Tm1 BcDNA:SD21996 (FlyBase, 1996-) Source for merge of: Tm1 l(3)S130510 (Li and Gao, 2003)
Additional comments	Relationship between "l(3)88EFi" and "Tm1" is unclear; a temperature-sensitive "l(3)88EFi" allele partially complements Tm102299 at 29oC. (Zraly et al., 2002) Source for merge of Tm1 BcDNA:GH09289 was a shared cDNA (date:030728). (FlyBase, 1996-) Source for merge of Tm1 BcDNA:LD37158 was a shared cDNA (date:020730). (FlyBase, 1996-) Source for merge of Tm1 BcDNA:SD21996 was a shared cDNA (date:030728). (FlyBase, 1996-)
Other Comments
	The 'heavy tropomyosins', TmH-33 and TmH-34, are encoded by the Tm1 gene, using exons 16 and 15, respectively. They are specifically expressed in the indirect flight muscles. (Mateos et al., 2006) ChEST reveals this is a target of Mef2. (Junion et al., 2005) dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation. (Rogers et al., 2003) Area matching Drosophila EST AI109898. (Davies, 2001.3.15) GstS1 interacts with the TnH-34 isoform of troponin-H in asynchronous indirect flight muscle. (Clayton et al., 1998) Identification: Enhancer trap expression pattern survey for loci expressed in the ring gland. (Harvie et al., 1998) Tm1 is required for specific cell movements during head morphogenesis and for accumulating high levels of osk mRNA at the posterior pole necessary for germ cell formation but not for abdominal development. (Tetzlaff et al., 1996) Tm1 regulatory regions have high affinity binding sites for Cf2, gel mobility shift assays reveal that Cf2 recognises a target site in the Tm1 enhancer region located in the first intron. (Bagni and Kafatos, 1995) Mutations in Tm1 virtually abolish osk RNA localisation to the posterior pole suggesting an involvement of the actin network in osk RNA localisation. (Erdelyi et al., 1995) Gel mobility shift assays have revealed a Mef2 binding site in Tm1 gene proximal enhancer. (Lin et al., 1995) Tm1 cis-acting sequences contain a 90bp muscle activator site (MA), the region is sufficient to direct low level transcriptional regulation of an Hsp70/Ecol\lacZ reporter gene in all somatic and visceral muscles of the embryo and adult. (Lin and Storti, 1995) Tm1 mRNA synthesis and accumulation in the developing ovary and embryo has been studied. lac reporter gene constructs demonstrate 1.2kb of 5' sequence upstream of the Tm1 transcription start site is required to drive expression of both the maternal and zygotic transcripts in the nurse cells and embryo but not in the follicle cells of the ovariole. (Hales et al., 1994) The distribution of muscle enhancer elements and their control is similar to those regulating the expression of Tm1. (Gremke et al., 1993) Tm1 transcription is controlled by multiple muscle type-specific cis-acting control elements and upstream and downstream promoter control elements. (Meredith and Storti, 1993) Three variants of Tm1 have been determined, this variation does not affect flight ability. (Cripps and Sparrow, 1992) Three variants of Tm1 have been determined by their mobility on 1-D and 2-D SDS-PAGE. (Cripps and Sparrow, 1992) Tm1 acts as a regulator of motility in muscle and nonmuscle cells. (Lindsley and Zimm, 1992) Structural gene for tropomyosin, a 34,000-dalton protein. At least five tropomyosin isoforms are encoded by Tm1, some in embryos (during myogenesis) and myogenic cell culture and others in the myofibrils of adult indirect flight muscles and leg muscles. (Lindsley and Zimm, 1992) Tm1, muscle promoter of Tm2, Act57B and Mlc2 were not transcribed by embryonic extracts. The contractile protein genes may possess a common feature related to in vitro transcription that prevents their transcription. (Lichter and Storti, 1991) Tm1 has been cloned and sequenced. (Hanke and Storti, 1988) Tm1 has been sequenced, and its expression pattern analysed. (Basi et al., 1984) Defined during molecular analysis of the 88F region. (Karlik et al., 1984)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079636 NM_169633 NM_169634 NM_169635 NM_169636 NM_169637 NM_169638 NM_169639 NM_169640 NM_169641 NM_206494 NM_206495 NM_001170148 NM_001260190 NM_001260191 NM_001275661 NM_001275662 RefSeq (Proteins) • NP_524360 NP_732001 NP_732002 NP_732003 NP_732004 NP_732005 NP_732006 NP_732007 NP_732008 NP_732009 NP_996216 NP_996217 NP_001163619 NP_001247119 NP_001247120 NP_001262590 NP_001262591 DDBJ / EMBL / GenBank • AA246548 AA392213 AA567134 AA816806 AAA28965 AAA28966 AAA28967 AAA28968 AAA28969 AAA28972 AAA28975 AAF55163 AAF55164 AAL25301 AAL25453 AAN13644 AAN13645 AAN13646 AAN13647 AAN13648 AAN13649 AAN13650 AAN13651 AAN71289 AAN71691 AAS65155 AAS65156 ACZ94915 AFH06437 AFH06438 AGB95971 AGB95972 AI109898 AI456972 AI945031 AW940314 AW943369 AX094111 AY060262 AY060414 BG633523 BI167669 BI231503 BI639426 BT001534 BT001902 CAA53800 CAA53801 CL844495 CZ469463 CZ471925 CZ478856 CZ478978 CZ478979 CZ481166 CZ481172 CZ482841 J03502 K02620 K02621 L00355 L00356 L00357 L00358 L00359 L00360 L00361 L00362 L00363 M12840 M13023 M15466 X76208 Entrez Gene - A searchable database of RefSeq genes. • 41852 UniProtKB/Swiss-Prot • P06754 P49455 UniProtKB/TrEMBL • Q6LEH1 Q6NN28 Q8IG84 Q8IGY1 Q95TA3
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Tropomyosin (IPR000533) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GH09289 LD37158
Linkouts
	BioGRID - A database of protein and genetic interactions • 66916 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0003721 DroID - A comprehensive database of gene and protein interactions. • FBgn0003721 DRSC - Results from RNAi screens. • FBgn0003721 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003721 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4898-RE;CG4898-RC;CG4898-RB;CG4898-RA;HDC13727;S.C3R001542 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0003721 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41852 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41852 modMine - Data generated by the modENCODE project. • FBgn0003721 REDfly - A database of transcriptional regulatory elements. • FBgn0003721
Synonyms & Secondary IDs ( 52 )
Reported As
Symbol Synonym	1305/10 (Deak et al., 1997) 2299 (Harvie et al., 1998) BcDNA:GH09289   BcDNA:LD37158   BcDNA:SD21996   CG4898 (Goldstein and Gunawardena, 2000, Rogers et al., 2003, Quinones-Coello, 2007, Quinones-Coello, 2007, Cammarato et al., 2011, Ni et al., 2010.12.1) cTm (Ward et al., 2003, Strigini and Cohen, 2000, Halsell and Kiehart, 1998, Hales et al., 1994, Basi et al., 1984, Iwasa and Mullins, 2007) cTM (Gavis, 1997) cTmII (Nasmyth and Jansen, 1997, Bassell and Singer, 1997, Tetzlaff et al., 1996) Dm Tm1 (Herranz et al., 2005) DmTm1 (Mateos et al., 2006) Dm TmH33 (Mateos et al., 2006) Dm TmH34 (Mateos et al., 2006) l(3)02299   l(3)s2958   l(3)S130510 (Szeged Stock Center, 1998-, ) mTmII (Boardman et al., 1985, Basi et al., 1984, Bautch and Storti, 1983) PmI   region 3 (Bautch and Storti, 1983) Tm (Nongthomba et al., 2004, Clayton et al., 1998, Lindquist et al., 2011) TM (Bai et al., 2009) Tm1 (Stark et al., 2005, Montana and Littleton, 2006, Buszczak et al., 2007, Quinones-Coello, 2007, Quinones-Coello, 2007, Lecuyer et al., 2007, Dietzl et al., 2007, Mateos et al., 2006, Gabut et al., 2007, Knowles-Barley et al., 2010, Rees et al., 2011, Kim et al., 2011, Cash and Andrews, 2012, Hudson et al., 2008, Sharma and Singh, 2009, Potthoff and Olson, 2007, Sahota et al., 2009, García-Zaragoza et al., 2008, Bandyopadhyay et al., 2006, Adryan et al., 2007, Zhao et al., 2010, Texada et al., 2011, Kaushik et al., 2012) tm1 (Papatsenko et al., 2006, Stephan et al., 2012) TM1 (Schaub et al., 2012) TmH-33 (Mateos et al., 2006, Vikhorev et al., 2010) TmH33 (Mateos et al., 2006) TmH-34 (Mateos et al., 2006, Vikhorev et al., 2010) TmH34 (Mateos et al., 2006) TmII (Szuperak et al., 2005, Herranz et al., 2004, Cooperstock and Lipshitz, 1997, Palacios and St. Johnston, 2002, Johnstone and Lasko, 2001, Jankovics et al., 2001, Hanke, 1993.12.1, Hazelrigg, 1998, Robinson and Cooley, 1997, Ephrussi, 1996, Kreuz et al., 1996, Grunert and St. Johnston, 1996, Kreuz et al., 1996, Markussen et al., 1995, Erdelyi et al., 1995, Meredith and Storti, 1993, Gremke et al., 1993, Cripps and Sparrow, 1992, Hanke and Storti, 1988, Sandmann et al., 2006, Zimyanin et al., 2008, Wong et al., 2011) TMII (Li and Gao, 2003, Bonin and Mann, 2004, Mateos et al., 2002, Janzer and Steinmann-Zwicky, 2001) tmII (Tekotte and Davis, 2002) Tmr33 (Karlik et al., 1984) Tmr34 (Karlik et al., 1984) TnH (Vigoreaux, 2001, Razzaq et al., 1999, Clayton et al., 1998, Haigh et al., 2010) TnH-33 (Clayton et al., 1998) TnH-34 (Cripps and Sparrow, 1992, Clayton et al., 1998) tropomyosin (Clayton et al., 1998) unnamed (Pizzari, 2004)
Name Synonym	cytoplasmic tropomyosin (Strigini and Cohen, 2000) cytoskeletal Tropomyosin (Ward et al., 2002) Tropomyosin (Mas et al., 2004, Garcia-Zaragoza et al., 2004, Ward et al., 2003, Taylor, 1998, Schaub et al., 2012, Ismat et al., 2010) tropomyosin (Paululat et al., 1999, van Straaten et al., 1999, Fyrberg et al., 1991, Clyne et al., 2003, Mardahl-Dumesnil and Fowler, 2001, Halsell and Kiehart, 1998, Texada et al., 2007, Nguyen and Frasch, 2006, Bai et al., 2009, Vikhorev et al., 2010) Tropomyosin-1 (Fyrberg et al., 1988) Tropomyosin 1 (Mack et al., 2006, Rogers et al., 2003, Pedersen et al., 2010, Gabut et al., 2007, Rudolf et al., 2012, Hudson et al., 2008, Lebo et al., 2009, Potthoff and Olson, 2007, García-Zaragoza et al., 2008, Zhao et al., 2010, Cammarato et al., 2011, Kaplow et al., 2007, Texada et al., 2011) Tropomyosin I (D'Avino et al., 2008, Sandmann et al., 2006, Cash and Andrews, 2012) tropomyosin II (Cervera et al., 2005, Fischer, 2000, Vieira et al., 2000, Saffman and Lasko, 1999, Williamson and Lehmann, 1996, Hanke, 1993.12.1, Irion et al., 2006) Tropomyosin II (Grueber and Jan, 2004, Sweeney et al., 1999, Zimyanin et al., 2008, Texada et al., 2011) tropomyosinII (Morin et al., 2001) tropomysin II (Extavour and Akam, 2003, Wylie, 1999, Rogers et al., 2003) Troponin H (Jacinto and Baum, 2003) troponin-H (Clayton et al., 1998) troponin H (Haigh et al., 2010) troponin-H isoform 34 (Clayton et al., 1998)
Secondary FlyBase IDs
	FBgn0010776 FBgn0011036 FBgn0015832 FBgn0015833 FBgn0046771 FBgn0046800 FBgn0060408 FBgn0064771
References ( 202 )
Generate a list of	All references relating to this gene ( 202 )
List References by type	Research paper  ( 106 ) Supplementary material  ( 15 ) Review  ( 31 ) Personal communication to FlyBase  ( 13 ) Abstract  ( 21 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 2 ) Conference report  ( 1 ) Stock list  ( 1 ) Curated genome annotation  ( 4 ) Patent  ( 1 ) Book  ( 1 ) Protein sequence record  ( 2 ) Website  ( 1 )
Recent research papers ( 11 )
	Cash and Andrews, 2012, BMC Dev. Biol. 12: 4 Fine scale analysis of gene expression in Drosophila melanogaster gonads reveals Programmed cell death 4 promotes the differentiation of female germline stem cells. [FBrf0217547] Ezkurdia et al., 2012, Mol. Biol. Evol. 29(9): 2265--2283 Comparative proteomics reveals a significant bias toward alternative protein isoforms with conserved structure and function. [FBrf0219265] Rudolf et al., 2012, Europ. J. Cell Biol. 91(3): 192--203 The syncytial visceral and somatic musculature develops independently of β3-Tubulin during Drosophila embryogenesis, while maternally supplied β1-Tubulin is stable until the early steps of myoblast fusion. [FBrf0217503] Schaub et al., 2012, Development 139(5): 1001--1012 Org-1, the Drosophila ortholog of Tbx1, is a direct activator of known identity genes during muscle specification. [FBrf0217455] Stephan et al., 2012, J. Neurosci. 32(46): 16080--16094 Drosophila Psidin Regulates Olfactory Neuron Number and Axon Targeting through Two Distinct Molecular Mechanisms. [FBrf0220017] Tauc et al., 2012, genesis 50(6): 466--481 A role for Drosophila Wnt-4 in heart development. [FBrf0218607] Kim et al., 2011, Genes Dev. 25(7): 730--741 Psidin, a conserved protein that regulates protrusion dynamics and cell migration. [FBrf0213388] Lindquist et al., 2011, Genome Res. 21(3): 433--446 Genome-scale RNAi on living-cell microarrays identifies novel regulators of Drosophila melanogaster TORC1-S6K pathway signaling. [FBrf0213199] Rees et al., 2011, Mol. Cell. Proteomics 10(6): M110.002386 In Vivo Analysis of Proteomes and Interactomes Using Parallel Affinity Capture (iPAC) Coupled to Mass Spectrometry. [FBrf0213845] Texada et al., 2011, Exp. Cell Res. 317(4): 474--487 Tropomyosin is an interaction partner of the Drosophila coiled coil protein Yuri Gagarin. [FBrf0212786] Wong et al., 2011, EMBO J. 31(4): 1028--1040 Rescue of tropomyosin deficiency in Drosophila and human cancer cells by synaptopodin reveals a role of tropomyosin α in RhoA stabilization. [FBrf0217514] Show all research papers ...
Recent reviews ( 1 )
	Kaushik et al., 2012, J. Cell. Mol. Med. 16(8): 1656--1662 Measuring passive myocardial stiffness in Drosophila melanogaster to investigate diastolic dysfunction. [FBrf0219008] Show all reviews ...