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General Information
Symbol
Dmel\Egfr
Species
D. melanogaster
Name
Epidermal growth factor receptor
Annotation Symbol
CG10079
Feature Type
FlyBase ID
FBgn0003731
Gene Model Status
Stock Availability
Enzyme Name (EC)
Receptor protein-tyrosine kinase (2.7.10.1)
Gene Snapshot
Epidermal growth factor receptor (Egfr) encodes the transmembrane tyrosine kinase receptor for signaling ligands (encoded by grk, spi, vn, and Krn) in the TGFα family, which utilises the intracellular MAP kinase pathway. The product of Egfr contributes to growth regulation, cell survival and developmental patterning. [Date last reviewed: 2019-06-06]
Also Known As
DER, top, flb, Elp, torpedo
Key Links
Genomic Location
Cytogenetic map
Sequence location
2R:21,522,420..21,559,977 [+]
Recombination map
2-95
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily. (P04412)
Catalytic Activity (EC)
Experimental Evidence
-
Predictions / Assertions
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate (2.7.10.1)
Summaries
Gene Group (FlyBase)
RECEPTOR TYROSINE KINASES -
Receptor tyrosine kinases (RTK) are single-pass transmembrane receptors expressed on the plasma membrane. Upon the binding of an extracellular signalling molecule (e.g. growth factors, hormones), RTKs dimerize leading to the activation of the intracellular tyrosine kinase domain and intermolecular phosphorylation. The phosphotyrosines function as specific sites for the assembly, phosphorylation and activation of downstream signaling molecules. (Adapted from PMID:20602996).
Pathway (FlyBase)
Epidermal Growth Factor Receptor Signaling Pathway Core Components -
The Epidermal Growth Factor Receptor (EGFR) signaling pathway is used multiple times during development (FBrf0190321). It is activated by the binding of a secreted ligand to the receptor tyrosine kinase Egfr and acts via the canonical Ras/Raf/MAP kinase (ERK) cascade. (Adapted from FBrf0190321 and FBrf0221727).
Protein Function (UniProtKB)
Binds to four ligands: Spitz, Gurken, Vein and Argos, which is an antagonist. Transduces the signal through the ras-raf-MAPK pathway. Involved in a myriad of developmental decisions. Critical for the proliferation of imaginal tissues, and for the determination of both the antero-posterior and dorso-ventral polarities of the oocyte. In the embryo, plays a role in the establishment of ventral cell fates, maintenance of amnioserosa and ventral neuroectodermal cells, germ band retraction, cell fate specification in the central nervous system and production of cuticle. Required for embryonic epithelial tissue repair.
(UniProt, P04412)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
Egfr: Epidermal growth factor receptor homologue
Encodes the Drosophila homolog of epidermal growth factor receptor protein. Mutations with three different phenotypes and described under three different names shown to be alleles of Egfr. Elp (Ellipse) is a dominant eye shape and texture mutant; flb (faint little ball) is an embryonic lethal causing dorsalized embryos, and top (torpedo) is a maternal-effect lethal causing ventralized embryos; each of these classes is described in detail at the end of the entry; in situ hybridization with transcript-specific probes reveals uniform distribution of transcript during embryogenesis; in larvae, hybridization confined to mitotic tissues and not seen in cells with polytene chromosomes (Kammermeyer and Wadsworth, 1987, Development 100: 201-10). Transcript concentrated in cells of the central nervous system and gonial cells in adults.
EgfrE
Eyes of EgfrE/+ heterozygotes rough and more oval than wild type; also display a slight disturbance of the wing-vein pattern. Homozygotes have smaller eyes with many fewer ommatidia and some regions lack them entirely; those ommatidia that are formed contain the normal number and arrangement of cells; the regions without ommatidia contain cells that resemble pigment cells and mechanosensory bristles; only about one tenth the normal number of preommatidial cell clusters differentiate behind the morphogenetic furrow. EgfrE in heterozygous combination with a deficiency or null mutation for Egfr is normal in phenotype indicating that EgfrE alleles are hypermorphic.
Egfrf
Embryonic lethal. Embryos form a ball of dorsal hypoderm with the internal organs extruded anteriorly. Ventral cuticle absent or strongly reduced. First visible in extended-germ-band stage. Cells at the anterior and posterior ends of the embryo form clumps and slough off; very few head and gnathal cells remain. Substantial ectodermal cell death observed; germ band retraction fails to take place. Ultimately, cuticle formation produces mostly dorsal and lateral cuticular elements with but a narrow strip of denticles mid-ventrally. Hypomorphic alleles initiate but do not complete germ-band retraction; they show intermediate phenotypes with wider denticle bands and in weak alleles some head and telson structures are formed as well. No maternal effect as shown by pole-cell transplantation.
Egfrt
Maternal-effect lethal. Homozygous females lay eggs that are long and pointed at both ends. Such eggs often have only one fused dorsal appendage; also there is an increase in the number of follicle cells that give rise to the main body of the chorion at the expense of those ordinarily contributing to the operculum and dorsal appendages. Egfrt alleles are completely recessive and fully penetrant in homozygous females; the embryos never hatch. Homozygous and hemizygous adult flies exhibit incomplete fourth veins, absence of the anterior crossvein, rough eyes, loss of ocelli and ocellar bristles, and the loss of sensory bristles from the thorax. Changes in the embryonic pattern become visible at the beginning of gastrulation. Around the circumference of the embryo, 40% of the cells invaginate on the ventral side and form mesoderm; these cells become organized into two ventral furrows which are lost in later stages, and a mass of mesodermal cells fills the ventral half of the embryo. The only cuticle structure differentiated is a strip of dorsal hypoderm flanked by bands of ventral setae; lateral and ventral sides are made up of mesoderm. The head is reduced but filzkorper and spiracles are visible posteriorly. Experiments with germline mosaics produced by pole cell transplantation indicate that the mutant gives rise to ventralized eggs and embryos by interferring with processes taking place in somatic cells rather than germinal tissue. The mutant phenotype was only produced in mosaics in which wild-type germ cells were surrounded by Egfrt follicle cells and not by the reverse cell arrangement. Egfrt blocks dorsalization caused by fs(1)K10, but not that produced by dl females.
Summary (Interactive Fly)
transmembrane receptor tyrosine kinase for signaling ligands in the TGFα family (Gurken, Spitz, Vein, and Keren) - utilises the intracellular MAP kinase pathway - during oogenesis helps set up egg polarity, determines the identity of cells in the ectoderm - during larval stages participates in the development of the eye and wing - regulates growth, cell survival and developmental patterning
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
2

Please see the GBrowse view of Dmel\Egfr or the JBrowse view of Dmel\Egfr for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.51
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0071653
5698
1377
FBtr0071654
6124
1426
Additional Transcript Data and Comments
Reported size (kB)
7.6, 7.1 (northern blot)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0071570
153.6
1377
6.53
FBpp0071571
159.5
1426
7.03
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)
Interacts (when phosphorylated on tyrosine residues) with Vav (via SH2 domain).
(UniProt, P04412)
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Egfr using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (78 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR006211, InterPro:IPR017441
(assigned by InterPro )
inferred from electronic annotation with InterPro:IPR000308
(assigned by InterPro )
inferred from biological aspect of ancestor with PANTHER:PTN002356460
(assigned by GO_Central )
Biological Process (68 terms)
Terms Based on Experimental Evidence (67 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:Vav; FB:FBgn0040068
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
(assigned by UniProt )
inferred from mutant phenotype
(assigned by UniProt )
inferred from mutant phenotype
(assigned by CACAO )
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
(assigned by UniProt )
inferred from genetic interaction with FLYBASE:Myc; FB:FBgn0262656
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
(assigned by UniProt )
inferred from mutant phenotype
(assigned by UniProt )
inferred from mutant phenotype
inferred from mutant phenotype
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000698827
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN002356460
(assigned by GO_Central )
Cellular Component (5 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
colocalizes_with cytoneme
inferred from direct assay
inferred from high throughput direct assay
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000698827
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN002356460
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN002356460
(assigned by GO_Central )
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
dorsal ectoderm anlage

Comment: anlage in statu nascendi

ectoderm anlage

Comment: anlage in statu nascendi

head mesoderm anlage

Comment: anlage in statu nascendi

mesectoderm anlage

Comment: anlage in statu nascendi

mesoderm anlage

Comment: anlage in statu nascendi

trunk mesoderm anlage

Comment: anlage in statu nascendi

ventral ectoderm anlage

Comment: anlage in statu nascendi

visual anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

antennal anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

dorsal head epidermis anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

organism | ubiquitous

Comment: reference states 24 hr AEL

northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
radioisotope in situ
Stage
Tissue/Position (including subcellular localization)
Reference
organism | ubiquitous

Comment: reference states 10-14 hr AEL

Additional Descriptive Data
Egfr transcript is expressed in a quadrant pattern in the wing pouch (excluded from the D/V and A/P compartment boundaries), and in the presumptive mesonotum and notum. In the haltere disc, Egfr is expressed in the prsumptive mesonotum, and in a small region surrounding the D/V compartment boundary.
Transcript is detected in a subset of the longitudinal glia in the ventral midline.
Egfr transcripts are distributed uniformly in the undifferentiated part of the eye-antennal disc from the antennal disc to in or slightly ahead of the morphogenetic furrow. They are also detected in the larval optic lobe in a pattern similar to the protein distribution.
Egfr transcripts are first observed in the late syncytial blastoderm embryo and increase substantially during cellularization. In gastrulating embryos, signal is higher in the ectoderm than in the endoderm or mesoderm and the strongest expression is seen in the cephalic furrow. During germ band extension, Egfr transcripts continue to be detected in the ectoderm and in the mesoderm. As the neuroblasts segregate, expression is missing in the neuroblast layer but is seen as two stripes along the germ band in the ectoderm and in the meso erm. In the later part of germ band extension, expression is detected in the stomodeum, the clypeo-labrum, and in the gnathal segments. Egfr is therefore found in all primordial tissues of the mouthparts and foregut. At stage 14, expression is observed in the region where the posterior spiracles and the telson will form. From stage 14 on, expression is observed in the ventral midline of the CNS. In stages 15 and 16, expression is observed along the entire periphery of the midgut. At stage 17, the most prominent regions of expression include the internal part of the proventriculus, the epit elium of the pharynx, and the fat body. In third instar larvae, expression is observed in imaginal discs. Expression is not evenly distributed among the discs or in a single disc. For example, in the eye disc, expression is abundant and uniform anterior to the morphogenetic furrow but posterior to the furrow is only found in the basal portion of the disc. Expression in the discs is observed in the epithelium but not in the adepithelium. Egfr is also expressed unevenly in developing ovaries and is detected in restricted regions of the CNS. Expression is observed in the inner and outer proli eration centers and in cells of the developing optic lamina. In addition, expression is found in a subset of polytene larval tissues including the valvular epithelium of the proventriculus and the fat body. Low levels of expression are seen in the salivary glands and in a subset of cells in the Malphigian tubules. The larval pattern of expression continues into prepupae. In early pupae, expression continues in the disc epithelia, the optic lamina, and fat body. Weak expression is also observed around each ovarian egg chamber. Later in the pupal period, expression declines in the midgut epith lium and is observed in the fore- and hindguts. Egfr expression in adults is mainly restricted to three types of tissues; imaginal fat body, valvular epithelium of the proventriculus, and the follicular epithelium of the ovary.
Egfr transcripts are observed in the periphery of cellular blastoderm embryos and persist at least until ventral furrow formation. In larvae, transcripts are observed in all imaginal discs and in subsets of cells within the cortex of the brain but not in the salivary glands. The expressing cells in the brain are thought to correspond to the proliferative centers. This pattern is consisten with Egfr expression preferentially in mitotically active cells. In ovaries, expression is observed in the vitellogenic follicle cells in young egg chambers. Follicle cells surrounding more mature oocytes no longer have higher levels of Egfr than the surrounding cells. Some transcript is also found in nurse cells and in the oocyte. In adults, some Egfr transcript is observed in males and females in tissues other than the ovary showing that some Egfr is expressed in nonproliferating cells in adults.
Egfr transcripts were found to be uniformly distributed in 10-14hr embryos and in 24hr embryos. In larvae, transcripts are uniformly distributed in the brain cortex, the anlagen of the ovaries and testes and in imaginal discs including the eye-antennal, wing, and genital discs. In adults, transcripts are localized in the cortex of the brain and in the thoracic and abdominal ganglia.
Egfr transcripts are detected at all stages of development tested. They are expressed at high levels in embryos and at reduced levels in larvae and pupae. In adults the 7.6kb transcript is much less abundant than the 7.1kb transcript.
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
In eye imaginal discs, the highest levels of Egfr protein are found anterior to the morphogenetic furrow. Just posterior to the furrow, the levels are sharply reduced in cells not recruited into the ommatidia but remain high in photoreceptor precursor cells. In the posterior of the eye disc the pattern is reversed. Levels are low in the ommatidia and highest in the surrounding undifferentiated cells that will become pigment and bristle nerve cells.
Egfr protein is detected in wholemount imaginal discs in a relatively uniform distribution. In eye discs, protein is observed in the furrow and anterior to the furrow but not posterior to the furrow. In sectioned discs, Egfr protein appears to be limited to the apical microvillar border of the eye disc epithelium anterior to and within the furrow. Staining is also observed in the presumptive larval optic lobes in the lateral and outer proliferation centers of the lamina. Finally, staining is seen along the midline of the ventral nerve cord.
Egfr protein is widely distributed throughout the cellular blastoderm embryo. It appears to be localized at the periphery of cells in the newly formed plasma membranes. During gastrulation, it is expressed in all ectodermal epithelial cells. In germ band extended embryos, it continues to be expressed in the ectoderm and is also expressed in the newly formed mesodermal cell layer. Intense staining in the head is also observed particularly in the mandibular bud, the procephalic lobe, and the clypeolabrum. In germ band retracted embryos, staining is observed in the epidermis at the tip of the clypeolabrum and in the epithelium of the terminal portion of the hindgut. Epidermal staining is also seen in the segmental grooves. Egfr staining is pronounced in germ band retracted embryos at the sites of somatic muscle attachments where it localizes particularly to the tendon cells at the ectodermal epithelial aspect of the apodemes. Most splanchnic mesodermal derivatives express Egfr. Staining is apparent in the fat body and in the visceral musculature. Finally, staining is pronounced in the ventral midline of the CNS.
Marker for
 
Subcellular Localization
CV Term
Evidence
References
colocalizes_with cytoneme
inferred from direct assay
inferred from high throughput direct assay
Expression Deduced from Reporters
Reporter: P{Egfr-GAL4.R}
Stage
Tissue/Position (including subcellular localization)
Reference
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Egfr in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 132 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 46 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Egfr
Transgenic constructs containing regulatory region of Egfr
Deletions and Duplications ( 28 )
Partially duplicated in
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
adult cuticle & head capsule | dorsal, with Scer\GAL4c591
antenna & neuron | conditional ts, with Scer\GAL4hs.PB
axon & mechanosensory neuron & adult head, with Scer\GAL4unspecified
axon & ocellus sensory structure, with Scer\GAL4sca-537.4
border follicle cell & filopodium, with Scer\GAL4slbo.2.6
chordotonal organ precursor cell & ventral thoracic disc, with Scer\GAL4sca-109-68
cortical actin cytoskeleton & oocyte associated follicle cell, with Scer\GAL4slbo.2.6
embryonic trachea & cortical actin cytoskeleton, with Scer\GAL4btl.PS
head & macrochaeta | somatic clone
leg & macrochaeta | somatic clone
mesothoracic tarsal segment 1 & bract, with Scer\GAL4sca-537.4
mesothoracic tergum & macrochaeta | supernumerary, with Scer\GAL4ap-md544
microchaeta & abdominal sternite
microchaeta & abdominal tergite
neuron & eye disc | posterior | conditional ts (with Egfrf24)
neuron & eye disc | posterior | conditional ts (with Egfrtsla)
sensory neuron & axon & embryo, with Scer\GAL4repo
taste bristle & leg | ectopic, with Scer\GAL4Dll-md23
taste bristle & leg | ectopic, with Scer\GAL4sca-537.4
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (4)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
12 of 15
Yes
Yes
 
12 of 15
Yes
Yes
11 of 15
Yes
No
10 of 15
Yes
No
 
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (5)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
11 of 15
Yes
Yes
10 of 15
Yes
No
10 of 15
Yes
No
8 of 15
Yes
No
1 of 15
No
No
Rattus norvegicus (Norway rat) (6)
10 of 13
Yes
Yes
9 of 13
Yes
No
9 of 13
No
Yes
7 of 13
Yes
No
2 of 13
No
Yes
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (5)
5 of 12
Yes
Yes
4 of 12
No
Yes
4 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
No
Danio rerio (Zebrafish) (12)
9 of 15
Yes
Yes
8 of 15
No
Yes
8 of 15
No
Yes
7 of 15
No
Yes
6 of 15
No
Yes
5 of 15
No
Yes
4 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (5)
13 of 15
Yes
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (14)
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091900PG )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500CW )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W00AF )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X009U )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G00U7 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (23)
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 2 )
Allele
Disease
Evidence
References
Potential Models Based on Orthology ( 5 )
Modifiers Based on Experimental Evidence ( 3 )
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Interactions
Summary of Physical Interactions
esyN Network Diagram
Show neighbor-neighbor interactions:
Select Layout:
Legend:
Protein
RNA
Selected Interactor(s)
Interactions Browser

Please see the Physical Interaction reports below for full details
RNA-protein
Physical Interaction
Assay
References
protein-protein
Physical Interaction
Assay
References
Summary of Genetic Interactions
esyN Network Diagram