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Gene Dmel\trc

General Information
Symbol	Dmel\trc	Species	D. melanogaster
Name	tricornered	Annotation symbol	CG8637
Feature type	protein_coding_gene	FlyBase ID	FBgn0003744
Gene Model Status	Current	Stock availability	25 publicly available
Also Known As	NDR
Genomic Location
Chromosome (arm)	3L	Recombination map	3-46
Cytogenetic map	76D1-76D1	Sequence location	3L:19,823,964..19,827,404 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene tricornered is referred to in FlyBase by the symbol Dmel\trc (CG8637, FBgn0003744). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding. There is experimental evidence that it is involved in the biological process: chaeta development; regulation of dendrite morphogenesis; dendrite self-avoidance; dendrite morphogenesis; antennal morphogenesis; imaginal disc-derived wing morphogenesis; signal transduction; imaginal disc-derived wing hair organization. 35 alleles are reported. The phenotypes of these alleles are annotated with: organ system; organ system subdivision; adult segment; multicellular structure; sense organ; adult; cell cluster organ; acellular anatomical structure; appendage segment; eo support cell; cell part; embryonic/larval integumentary system. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: AGC-kinase, C-terminal; Protein kinase, ATP binding site; Protein kinase, C-terminal; Protein kinase, catalytic domain; Protein kinase-like domain; Serine/threonine- / dual specificity protein kinase, catalytic domain; Serine/threonine-protein kinase, active site. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages, during early pupal stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1628306_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of trc. Gene sequence location is 3L:19823964..19827404.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	trc: tricorner Mutant wing and notum have rosettes of three or more short trichomes instead of single long hairs as in wild type. Useful as cell marker. Mutant cell autonomous in mitotic cells in a wild-type background, but not in a Minute background (Vinson and Adler, 1987a).
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 76D1-76D1   Limits computationally determined from genome sequence between P{lacW}l(3)L3809L3809 and P{lacW}l(3)L1243L1243&P{lacW}Mi-2j3D4
Experimentally Determined Cytological Location
Cytogenetic map Notes References 76C-76C     (Adler, 2000.3.21) 76C-76C     (Geng, 2000.2.22) 76C4-76C6   (determined by in situ hybridisation)   (Szeged Stock Center, 1998-) 76C4-76C6   (determined by in situ hybridisation)   (Deak et al., 1997)
Experimentally Determined Recombination Data
Location	3-46   3-48 (Martin, 1995.12.5)
Left of (cM)	Pc
Right of (cM)
Notes	Mitotic location: 36. (Martin, 1995.12.5)
Gene Model & Products
Please see the GBrowse view of Dmel\trc for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.43 Gene model reviewed during 5.45
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) trc-RA FBtr0074922  NM_079446   2277   459 trc-RB FBtr0332154  NM_001275142   2816   463
Additional Transcript Data & Comments
Reported size (kB)	2.1 (longest cDNA) (Millward et al., 1995)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein trc-PA   FBpp0074691   52.9   459   6.37     NP_524170   AAF49104 trc-PB   FBpp0304464   53.3   463   6.37     NP_001262071   AGB94764
Additional Polypeptide Data & Comments
Reported size (kDa)	455 (aa); 52 (kD predicted) (Millward et al., 1995)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) AGC-kinase, C-terminal (IPR000961) Serine/threonine- / dual specificity protein kinase, catalytic domain (IPR002290) Serine/threonine-protein kinase, active site (IPR008271) Protein kinase-like domain (IPR011009) Protein kinase, ATP binding site (IPR017441) Protein kinase, C-terminal (IPR017892)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA440026   AA803390   AE014296 AAF49104   AF238490 AAF67167   AF239171 AAF67168   AF247814 AAF97511   AE014296 AGB94764   AI257917   AI293206   AI404371   AI456993   AW943372   AY051880 AAK93304   BF486026   BF486848   BF488387   BF494373   BI169122   BI236122   BI237382   BI237847   BI372519   BI613547   BI614653   BI616265   BP548354   CA807542   CO185547   CO264189   CO272660   CO277693   CO277694   CO285060   CO287168   CO287687   CO295450   CO296418   CO298864   CO300071   CO305963   CO323851   CO332819   CO333564   EC051305   EC052342   EC052378   EC053332   EC056289   EC056455   EC063773   EC068500   EC072357   EC078242   EC084099   EC084854   EC086175   EC213819   EC218511   EC220723   EC222782   EC224700   EC226368   EC232475   EC238537   EC239796   EC244388   EC254513   Z35103 CAA84486
UniProtKB/Swiss-Prot	Q9NBK5
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 11 -- 12   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 13 -- 16   organism | ubiquitous   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
cell cortex inferred from direct assay (He et al., 2005) cytoplasm inferred from direct assay (He et al., 2005, Horne-Badovinac et al., 2012) inferred from direct assay (assigned by UniProtKB) (He et al., 2005) nucleus inferred from direct assay (Horne-Badovinac et al., 2012) inferred from direct assay (assigned by UniProtKB) (He et al., 2005)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    225.5 Larval Midgut    365.3 Larval Hindgut    246 Larval Malpighian Tubules    82.4 Larval Fat Body    155.2 Larval Salivary Gland    149.5 Larval Trachea    109.5 Larval Carcass    338.3 Adult Head    265 Adult Eye    118.1 Adult Brain    387.2 Adult Thoracic-Abdominal Ganglion    348.5 Adult Crop    275.5 Adult Midgut    183.1 Adult Hindgut    198.2 Adult Malpighian Tubules    57.2 Adult Fat Body    169.1 Adult Salivary Gland    197.4 Adult Heart    111.425 Adult VirginFemale Spermatheca    72.4 Adult InseminatedFemale Spermatheca    72.5 Adult Ovary    551.7 Adult Testis    83.7 Adult Male Accessory Gland    117.4 Adult Carcass    233.4 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    225.5 Larval Midgut    365.3 Larval Hindgut    246 Larval Malpighian Tubules    82.4 Larval Fat Body    155.2 Larval Salivary Gland    149.5 Larval Trachea    109.5 Larval Carcass    338.3 Adult Head    265 Adult Eye    118.1 Adult Brain    387.2 Adult Thoracic-Abdominal Ganglion    348.5 Adult Crop    275.5 Adult Midgut    183.1 Adult Hindgut    198.2 Adult Malpighian Tubules    57.2 Adult Fat Body    169.1 Adult Salivary Gland    197.4 Adult Heart    111.425 Adult VirginFemale Spermatheca    72.4 Adult InseminatedFemale Spermatheca    72.5 Adult Ovary  (551.7) Adult Testis    83.7 Adult Male Accessory Gland    117.4 Adult Carcass    233.4 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    225.5 Larval Midgut    365.3 Larval Hindgut    246 Larval Malpighian Tubules    82.4 Larval Fat Body    155.2 Larval Salivary Gland    149.5 Larval Trachea    109.5 Larval Carcass    338.3 Adult Head    265 Adult Eye    118.1 Adult Brain    387.2 Adult Thoracic-Abdominal Ganglion    348.5 Adult Crop    275.5 Adult Midgut    183.1 Adult Hindgut    198.2 Adult Malpighian Tubules    57.2 Adult Fat Body    169.1 Adult Salivary Gland    197.4 Adult Heart    111.425 Adult VirginFemale Spermatheca    72.4 Adult InseminatedFemale Spermatheca    72.5 Adult Ovary    551.7 Adult Testis    83.7 Adult Male Accessory Gland    117.4 Adult Carcass    233.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    225.5 Larval Midgut    365.3 Larval Hindgut    246 Larval Malpighian Tubules    82.4 Larval Fat Body    155.2 Larval Salivary Gland    149.5 Larval Trachea    109.5 Larval Carcass    338.3 Adult Head    265 Adult Eye    118.1 Adult Brain    387.2 Adult Thoracic-Abdominal Ganglion    348.5 Adult Crop    275.5 Adult Midgut    183.1 Adult Hindgut    198.2 Adult Malpighian Tubules    57.2 Adult Fat Body    169.1 Adult Salivary Gland    197.4 Adult Heart    111.425 Adult VirginFemale Spermatheca    72.4 Adult InseminatedFemale Spermatheca    72.5 Adult Ovary    551.7 Adult Testis    83.7 Adult Male Accessory Gland    117.4 Adult Carcass    233.4 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    225.5 Larval Midgut    365.3 Larval Hindgut    246 Larval Malpighian Tubules    82.4 Larval Fat Body    155.2 Larval Salivary Gland    149.5 Larval Trachea    109.5 Larval Carcass    338.3 Adult Head    265 Adult Eye    118.1 Adult Brain    387.2 Adult Thoracic-Abdominal Ganglion    348.5 Adult Crop    275.5 Adult Midgut    183.1 Adult Hindgut    198.2 Adult Malpighian Tubules    57.2 Adult Fat Body    169.1 Adult Salivary Gland    197.4 Adult Heart    111.425 Adult VirginFemale Spermatheca    72.4 Adult InseminatedFemale Spermatheca    72.5 Adult Ovary    551.7 Adult Testis    83.7 Adult Male Accessory Gland    117.4 Adult Carcass    233.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    225.5 Larval Midgut    365.3 Larval Hindgut    246 Larval Malpighian Tubules    82.4 Larval Fat Body    155.2 Larval Salivary Gland    149.5 Larval Trachea    109.5 Larval Carcass    338.3 Adult Head    265 Adult Eye    118.1 Adult Brain    387.2 Adult Thoracic-Abdominal Ganglion    348.5 Adult Crop    275.5 Adult Midgut    183.1 Adult Hindgut    198.2 Adult Malpighian Tubules    57.2 Adult Fat Body    169.1 Adult Salivary Gland    197.4 Adult Heart    111.425 Adult VirginFemale Spermatheca    72.4 Adult InseminatedFemale Spermatheca    72.5 Adult Ovary  551.7 Adult Testis    83.7 Adult Male Accessory Gland    117.4 Adult Carcass    233.4 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    225.5 Larval Midgut    365.3 Larval Hindgut    246 Larval Malpighian Tubules    82.4 Larval Fat Body    155.2 Larval Salivary Gland    149.5 Larval Trachea    109.5 Larval Carcass    338.3 Adult Head    265 Adult Eye    118.1 Adult Brain    387.2 Adult Thoracic-Abdominal Ganglion    348.5 Adult Crop    275.5 Adult Midgut    183.1 Adult Hindgut    198.2 Adult Malpighian Tubules    57.2 Adult Fat Body    169.1 Adult Salivary Gland    197.4 Adult Heart    111.425 Adult VirginFemale Spermatheca    72.4 Adult InseminatedFemale Spermatheca    72.5 Adult Ovary    551.7 Adult Testis    83.7 Adult Male Accessory Gland    117.4 Adult Carcass    233.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    225.5 Larval Midgut    365.3 Larval Hindgut    246 Larval Malpighian Tubules    82.4 Larval Fat Body    155.2 Larval Salivary Gland    149.5 Larval Trachea    109.5 Larval Carcass    338.3 Adult Head    265 Adult Eye    118.1 Adult Brain    387.2 Adult Thoracic-Abdominal Ganglion    348.5 Adult Crop    275.5 Adult Midgut    183.1 Adult Hindgut    198.2 Adult Malpighian Tubules    57.2 Adult Fat Body    169.1 Adult Salivary Gland    197.4 Adult Heart    111.425 Adult VirginFemale Spermatheca    72.4 Adult InseminatedFemale Spermatheca    72.5 Adult Ovary    551.7 Adult Testis    83.7 Adult Male Accessory Gland    117.4 Adult Carcass    233.4 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    265   NA  Eye    118.1   NA  Brain    387.2   225.5  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    348.5   NA  Crop    275.5   365.3  Midgut    183.1   246  Hindgut    198.2   82.4  Malpighian Tubules    57.2   155.2  Fat Body    169.1   149.5  Salivary Gland    197.4   NA  Heart    111.425   109.5  Trachea    NA   NA  VirginFemale Spermatheca    72.4   NA  InseminatedFemale Spermatheca    72.5   NA  Ovary    551.7   NA  Testis    83.7   NA  Male Accessory Gland    117.4   338.3  Carcass    233.4 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    35 central nervous system, larvae L3    48 central nervous system, pupae P8    30 head, virgin 1-day female    29 head, virgin 4-day female    28 head, virgin 20-day female    21 head, mated 1-day female    31 head, mated 4-day female    27 head, mated 20-day female    19 head, mated 1-day male    36 head, mated 4-day male    53 head, mated 20-day male    54 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    28 digestive system, larvae L3 wandering    54 digestive system, 1-day adult    15 digestive system, 4-day adult    18 digestive system, 20-day adult    20 fat body, larvae L3 wandering    10 fat body, white prepupae    27 fat body, pupae P8    23 carcass, larvae L3 wandering    52 carcass, 1-day adult    27 carcass, 4-day adult    25 carcass, 20-day adult    21 ovary, virgin 4-day female    68 ovary, mated 4-day female    61 testis, mated 4-day male    20 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (35) central nervous system, larvae L3  (48) central nervous system, pupae P8  (30) head, virgin 1-day female  (29) head, virgin 4-day female  (28) head, virgin 20-day female    21 head, mated 1-day female  (31) head, mated 4-day female  (27) head, mated 20-day female    19 head, mated 1-day male  (36) head, mated 4-day male  (53) head, mated 20-day male  (54) salivary gland, larvae L3 wandering    7 salivary gland, white prepupae  (28) digestive system, larvae L3 wandering  (54) digestive system, 1-day adult    15 digestive system, 4-day adult    18 digestive system, 20-day adult    20 fat body, larvae L3 wandering    10 fat body, white prepupae  (27) fat body, pupae P8    23 carcass, larvae L3 wandering  (52) carcass, 1-day adult  (27) carcass, 4-day adult    25 carcass, 20-day adult    21 ovary, virgin 4-day female  (68) ovary, mated 4-day female  (61) testis, mated 4-day male    20 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    35 central nervous system, larvae L3    48 central nervous system, pupae P8    30 head, virgin 1-day female    29 head, virgin 4-day female    28 head, virgin 20-day female    21 head, mated 1-day female    31 head, mated 4-day female    27 head, mated 20-day female    19 head, mated 1-day male    36 head, mated 4-day male    53 head, mated 20-day male    54 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    28 digestive system, larvae L3 wandering    54 digestive system, 1-day adult    15 digestive system, 4-day adult    18 digestive system, 20-day adult    20 fat body, larvae L3 wandering    10 fat body, white prepupae    27 fat body, pupae P8    23 carcass, larvae L3 wandering    52 carcass, 1-day adult    27 carcass, 4-day adult    25 carcass, 20-day adult    21 ovary, virgin 4-day female    68 ovary, mated 4-day female    61 testis, mated 4-day male    20 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    35 central nervous system, larvae L3    48 central nervous system, pupae P8    30 head, virgin 1-day female    29 head, virgin 4-day female    28 head, virgin 20-day female    21 head, mated 1-day female    31 head, mated 4-day female    27 head, mated 20-day female    19 head, mated 1-day male    36 head, mated 4-day male    53 head, mated 20-day male    54 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    28 digestive system, larvae L3 wandering    54 digestive system, 1-day adult    15 digestive system, 4-day adult    18 digestive system, 20-day adult    20 fat body, larvae L3 wandering    10 fat body, white prepupae    27 fat body, pupae P8    23 carcass, larvae L3 wandering    52 carcass, 1-day adult    27 carcass, 4-day adult    25 carcass, 20-day adult    21 ovary, virgin 4-day female    68 ovary, mated 4-day female    61 testis, mated 4-day male    20 accessory gland, mated 4-day male    8 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    35 central nervous system, larvae L3    48 central nervous system, pupae P8    30 head, virgin 1-day female    29 head, virgin 4-day female    28 head, virgin 20-day female    21 head, mated 1-day female    31 head, mated 4-day female    27 head, mated 20-day female    19 head, mated 1-day male    36 head, mated 4-day male    53 head, mated 20-day male    54 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    28 digestive system, larvae L3 wandering    54 digestive system, 1-day adult    15 digestive system, 4-day adult    18 digestive system, 20-day adult    20 fat body, larvae L3 wandering    10 fat body, white prepupae    27 fat body, pupae P8    23 carcass, larvae L3 wandering    52 carcass, 1-day adult    27 carcass, 4-day adult    25 carcass, 20-day adult    21 ovary, virgin 4-day female    68 ovary, mated 4-day female    61 testis, mated 4-day male    20 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (35) central nervous system, larvae L3  (48) central nervous system, pupae P8  30 head, virgin 1-day female  29 head, virgin 4-day female  28 head, virgin 20-day female    21 head, mated 1-day female  31 head, mated 4-day female  27 head, mated 20-day female    19 head, mated 1-day male  (36) head, mated 4-day male  (53) head, mated 20-day male  (54) salivary gland, larvae L3 wandering    7 salivary gland, white prepupae  28 digestive system, larvae L3 wandering  (54) digestive system, 1-day adult    15 digestive system, 4-day adult    18 digestive system, 20-day adult    20 fat body, larvae L3 wandering    10 fat body, white prepupae  27 fat body, pupae P8    23 carcass, larvae L3 wandering  (52) carcass, 1-day adult  27 carcass, 4-day adult    25 carcass, 20-day adult    21 ovary, virgin 4-day female  (68) ovary, mated 4-day female  (61) testis, mated 4-day male    20 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    35 central nervous system, larvae L3    48 central nervous system, pupae P8    30 head, virgin 1-day female    29 head, virgin 4-day female    28 head, virgin 20-day female    21 head, mated 1-day female    31 head, mated 4-day female    27 head, mated 20-day female    19 head, mated 1-day male    36 head, mated 4-day male    53 head, mated 20-day male    54 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    28 digestive system, larvae L3 wandering    54 digestive system, 1-day adult    15 digestive system, 4-day adult    18 digestive system, 20-day adult    20 fat body, larvae L3 wandering    10 fat body, white prepupae    27 fat body, pupae P8    23 carcass, larvae L3 wandering    52 carcass, 1-day adult    27 carcass, 4-day adult    25 carcass, 20-day adult    21 ovary, virgin 4-day female    68 ovary, mated 4-day female    61 testis, mated 4-day male    20 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    35 central nervous system, larvae L3    48 central nervous system, pupae P8    30 head, virgin 1-day female    29 head, virgin 4-day female    28 head, virgin 20-day female    21 head, mated 1-day female    31 head, mated 4-day female    27 head, mated 20-day female    19 head, mated 1-day male    36 head, mated 4-day male    53 head, mated 20-day male    54 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    28 digestive system, larvae L3 wandering    54 digestive system, 1-day adult    15 digestive system, 4-day adult    18 digestive system, 20-day adult    20 fat body, larvae L3 wandering    10 fat body, white prepupae    27 fat body, pupae P8    23 carcass, larvae L3 wandering    52 carcass, 1-day adult    27 carcass, 4-day adult    25 carcass, 20-day adult    21 ovary, virgin 4-day female    68 ovary, mated 4-day female    61 testis, mated 4-day male    20 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages, during early pupal stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    58 embryo 02-04hr    11 embryo 04-06hr    22 embryo 06-08hr    36 embryo 08-10hr    35 embryo 10-12hr    32 embryo 12-14hr    31 embryo 14-16hr    28 embryo 16-18hr    25 embryo 18-20hr    22 embryo 20-22hr    18 embryo 22-24hr    19 larva L1    20 larva L2    19 larva L3 12hr old    11 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    27 larva L3 puffstage 7-9    41 white prepupae new    55 white prepupae 12hr    57 white prepupae 24hr    47 pupae 2d postWPP    27 pupae 3d postWPP    19 pupae 4d postWPP    23 adult male 01day    24 adult male 05day    21 adult male 30day    19 adult female 01day    35 adult female 05day    44 adult female 30day    46 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (58) embryo 02-04hr    11 embryo 04-06hr    22 embryo 06-08hr  (36) embryo 08-10hr  (35) embryo 10-12hr  (32) embryo 12-14hr  (31) embryo 14-16hr  (28) embryo 16-18hr    25 embryo 18-20hr    22 embryo 20-22hr    18 embryo 22-24hr    19 larva L1    20 larva L2    19 larva L3 12hr old    11 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6  (27) larva L3 puffstage 7-9  (41) white prepupae new  (55) white prepupae 12hr  (57) white prepupae 24hr  (47) pupae 2d postWPP  (27) pupae 3d postWPP    19 pupae 4d postWPP    23 adult male 01day    24 adult male 05day    21 adult male 30day    19 adult female 01day  (35) adult female 05day  (44) adult female 30day  (46) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    58 embryo 02-04hr    11 embryo 04-06hr    22 embryo 06-08hr    36 embryo 08-10hr    35 embryo 10-12hr    32 embryo 12-14hr    31 embryo 14-16hr    28 embryo 16-18hr    25 embryo 18-20hr    22 embryo 20-22hr    18 embryo 22-24hr    19 larva L1    20 larva L2    19 larva L3 12hr old    11 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    27 larva L3 puffstage 7-9    41 white prepupae new    55 white prepupae 12hr    57 white prepupae 24hr    47 pupae 2d postWPP    27 pupae 3d postWPP    19 pupae 4d postWPP    23 adult male 01day    24 adult male 05day    21 adult male 30day    19 adult female 01day    35 adult female 05day    44 adult female 30day    46 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    58 embryo 02-04hr    11 embryo 04-06hr    22 embryo 06-08hr    36 embryo 08-10hr    35 embryo 10-12hr    32 embryo 12-14hr    31 embryo 14-16hr    28 embryo 16-18hr    25 embryo 18-20hr    22 embryo 20-22hr    18 embryo 22-24hr    19 larva L1    20 larva L2    19 larva L3 12hr old    11 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    27 larva L3 puffstage 7-9    41 white prepupae new    55 white prepupae 12hr    57 white prepupae 24hr    47 pupae 2d postWPP    27 pupae 3d postWPP    19 pupae 4d postWPP    23 adult male 01day    24 adult male 05day    21 adult male 30day    19 adult female 01day    35 adult female 05day    44 adult female 30day    46 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    58 embryo 02-04hr    11 embryo 04-06hr    22 embryo 06-08hr    36 embryo 08-10hr    35 embryo 10-12hr    32 embryo 12-14hr    31 embryo 14-16hr    28 embryo 16-18hr    25 embryo 18-20hr    22 embryo 20-22hr    18 embryo 22-24hr    19 larva L1    20 larva L2    19 larva L3 12hr old    11 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    27 larva L3 puffstage 7-9    41 white prepupae new    55 white prepupae 12hr    57 white prepupae 24hr    47 pupae 2d postWPP    27 pupae 3d postWPP    19 pupae 4d postWPP    23 adult male 01day    24 adult male 05day    21 adult male 30day    19 adult female 01day    35 adult female 05day    44 adult female 30day    46 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (58) embryo 02-04hr    11 embryo 04-06hr    22 embryo 06-08hr  (36) embryo 08-10hr  (35) embryo 10-12hr  32 embryo 12-14hr  31 embryo 14-16hr  28 embryo 16-18hr    25 embryo 18-20hr    22 embryo 20-22hr    18 embryo 22-24hr    19 larva L1    20 larva L2    19 larva L3 12hr old    11 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6  27 larva L3 puffstage 7-9  (41) white prepupae new  (55) white prepupae 12hr  (57) white prepupae 24hr  (47) pupae 2d postWPP  27 pupae 3d postWPP    19 pupae 4d postWPP    23 adult male 01day    24 adult male 05day    21 adult male 30day    19 adult female 01day  (35) adult female 05day  (44) adult female 30day  (46) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    58 embryo 02-04hr    11 embryo 04-06hr    22 embryo 06-08hr    36 embryo 08-10hr    35 embryo 10-12hr    32 embryo 12-14hr    31 embryo 14-16hr    28 embryo 16-18hr    25 embryo 18-20hr    22 embryo 20-22hr    18 embryo 22-24hr    19 larva L1    20 larva L2    19 larva L3 12hr old    11 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    27 larva L3 puffstage 7-9    41 white prepupae new    55 white prepupae 12hr    57 white prepupae 24hr    47 pupae 2d postWPP    27 pupae 3d postWPP    19 pupae 4d postWPP    23 adult male 01day    24 adult male 05day    21 adult male 30day    19 adult female 01day    35 adult female 05day    44 adult female 30day    46 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    58 embryo 02-04hr    11 embryo 04-06hr    22 embryo 06-08hr    36 embryo 08-10hr    35 embryo 10-12hr    32 embryo 12-14hr    31 embryo 14-16hr    28 embryo 16-18hr    25 embryo 18-20hr    22 embryo 20-22hr    18 embryo 22-24hr    19 larva L1    20 larva L2    19 larva L3 12hr old    11 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    27 larva L3 puffstage 7-9    41 white prepupae new    55 white prepupae 12hr    57 white prepupae 24hr    47 pupae 2d postWPP    27 pupae 3d postWPP    19 pupae 4d postWPP    23 adult male 01day    24 adult male 05day    21 adult male 30day    19 adult female 01day    35 adult female 05day    44 adult female 30day    46 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    54 Schneider line 2 Sg4    37 embryonic 1182-4H    38 embryonic GM2    43 embryonic Kc167    43 embryonic S1    44 embryonic S3    34 leg disc CME L1    47 wing disc CME-W2    25 wing disc ML-DmD8    28 wing disc ML-DmD9    40 wing disc ML-DmD16-c3    49 wing disc ML-DmD21    31 wing disc ML-DmD32    25 haltere disc ML-DmD17-c3    28 eye-antennal disc ML-DmD11    41 antennal disc ML-DmD20-c5    29 mixed discs ML-DmD4-c1    34 CNS ML-DmBG1-c1    56 CNS ML-DmBG2-c2    23 tumorous blood cells mbn2    22 ovary fGS/OSS    44 ovary OSC    45 ovary OSS    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (54) Schneider line 2 Sg4  (37) embryonic 1182-4H  (38) embryonic GM2  (43) embryonic Kc167  (43) embryonic S1  (44) embryonic S3  (34) leg disc CME L1  (47) wing disc CME-W2    25 wing disc ML-DmD8  (28) wing disc ML-DmD9  (40) wing disc ML-DmD16-c3  (49) wing disc ML-DmD21  (31) wing disc ML-DmD32    25 haltere disc ML-DmD17-c3  (28) eye-antennal disc ML-DmD11  (41) antennal disc ML-DmD20-c5  (29) mixed discs ML-DmD4-c1  (34) CNS ML-DmBG1-c1  (56) CNS ML-DmBG2-c2    23 tumorous blood cells mbn2    22 ovary fGS/OSS  (44) ovary OSC  (45) ovary OSS    25 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    54 Schneider line 2 Sg4    37 embryonic 1182-4H    38 embryonic GM2    43 embryonic Kc167    43 embryonic S1    44 embryonic S3    34 leg disc CME L1    47 wing disc CME-W2    25 wing disc ML-DmD8    28 wing disc ML-DmD9    40 wing disc ML-DmD16-c3    49 wing disc ML-DmD21    31 wing disc ML-DmD32    25 haltere disc ML-DmD17-c3    28 eye-antennal disc ML-DmD11    41 antennal disc ML-DmD20-c5    29 mixed discs ML-DmD4-c1    34 CNS ML-DmBG1-c1    56 CNS ML-DmBG2-c2    23 tumorous blood cells mbn2    22 ovary fGS/OSS    44 ovary OSC    45 ovary OSS    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    54 Schneider line 2 Sg4    37 embryonic 1182-4H    38 embryonic GM2    43 embryonic Kc167    43 embryonic S1    44 embryonic S3    34 leg disc CME L1    47 wing disc CME-W2    25 wing disc ML-DmD8    28 wing disc ML-DmD9    40 wing disc ML-DmD16-c3    49 wing disc ML-DmD21    31 wing disc ML-DmD32    25 haltere disc ML-DmD17-c3    28 eye-antennal disc ML-DmD11    41 antennal disc ML-DmD20-c5    29 mixed discs ML-DmD4-c1    34 CNS ML-DmBG1-c1    56 CNS ML-DmBG2-c2    23 tumorous blood cells mbn2    22 ovary fGS/OSS    44 ovary OSC    45 ovary OSS    25 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    54 Schneider line 2 Sg4    37 embryonic 1182-4H    38 embryonic GM2    43 embryonic Kc167    43 embryonic S1    44 embryonic S3    34 leg disc CME L1    47 wing disc CME-W2    25 wing disc ML-DmD8    28 wing disc ML-DmD9    40 wing disc ML-DmD16-c3    49 wing disc ML-DmD21    31 wing disc ML-DmD32    25 haltere disc ML-DmD17-c3    28 eye-antennal disc ML-DmD11    41 antennal disc ML-DmD20-c5    29 mixed discs ML-DmD4-c1    34 CNS ML-DmBG1-c1    56 CNS ML-DmBG2-c2    23 tumorous blood cells mbn2    22 ovary fGS/OSS    44 ovary OSC    45 ovary OSS    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (54) Schneider line 2 Sg4  (37) embryonic 1182-4H  (38) embryonic GM2  (43) embryonic Kc167  (43) embryonic S1  (44) embryonic S3  (34) leg disc CME L1  (47) wing disc CME-W2    25 wing disc ML-DmD8  28 wing disc ML-DmD9  (40) wing disc ML-DmD16-c3  (49) wing disc ML-DmD21  31 wing disc ML-DmD32    25 haltere disc ML-DmD17-c3  28 eye-antennal disc ML-DmD11  (41) antennal disc ML-DmD20-c5  29 mixed discs ML-DmD4-c1  (34) CNS ML-DmBG1-c1  (56) CNS ML-DmBG2-c2    23 tumorous blood cells mbn2    22 ovary fGS/OSS  (44) ovary OSC  (45) ovary OSS    25 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    54 Schneider line 2 Sg4    37 embryonic 1182-4H    38 embryonic GM2    43 embryonic Kc167    43 embryonic S1    44 embryonic S3    34 leg disc CME L1    47 wing disc CME-W2    25 wing disc ML-DmD8    28 wing disc ML-DmD9    40 wing disc ML-DmD16-c3    49 wing disc ML-DmD21    31 wing disc ML-DmD32    25 haltere disc ML-DmD17-c3    28 eye-antennal disc ML-DmD11    41 antennal disc ML-DmD20-c5    29 mixed discs ML-DmD4-c1    34 CNS ML-DmBG1-c1    56 CNS ML-DmBG2-c2    23 tumorous blood cells mbn2    22 ovary fGS/OSS    44 ovary OSC    45 ovary OSS    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    54 Schneider line 2 Sg4    37 embryonic 1182-4H    38 embryonic GM2    43 embryonic Kc167    43 embryonic S1    44 embryonic S3    34 leg disc CME L1    47 wing disc CME-W2    25 wing disc ML-DmD8    28 wing disc ML-DmD9    40 wing disc ML-DmD16-c3    49 wing disc ML-DmD21    31 wing disc ML-DmD32    25 haltere disc ML-DmD17-c3    28 eye-antennal disc ML-DmD11    41 antennal disc ML-DmD20-c5    29 mixed discs ML-DmD4-c1    34 CNS ML-DmBG1-c1    56 CNS ML-DmBG2-c2    23 tumorous blood cells mbn2    22 ovary fGS/OSS    44 ovary OSC    45 ovary OSS    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    35 cold shock, 4-day adult    26 heat shock, 4-day adult    31 Cadmium 50 mM 6 hrs, larvae L3    14 Cadmium 50 mM 12 hrs, larvae L3    23 Cadmium 50 mM 48 hrs, 4-day adult    29 Cadmium 100 mM 48 hrs, 4-day adult    47 Copper 0.5 mM 12 hrs, larvae L3    15 Copper 15 mM 48 hrs, 4-day adult    40 Zinc 5 mM 12 hrs, larvae L3    14 Zinc 4.5 mM 48 hrs, 4-day adult    24 Ethanol 2.5% 3 hrs, larvae L3    53 Ethanol 5% 3 hrs, larvae L3    14 Ethanol 10% 3 hrs, larvae L3    15 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    48 Caffeine 25 mg/ml 48 hrs, 4-day adult    33 Paraquat 5 mM 48 hrs, 4-day adult    43 Paraquat 10 mM 48 hrs, 4-day adult    45 Rotenone 2 μg 12 hrs, larvae L3    15 Rotenone 8 μg 12 hrs, larvae L3    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (35) cold shock, 4-day adult  26 heat shock, 4-day adult  (31) Cadmium 50 mM 6 hrs, larvae L3    14 Cadmium 50 mM 12 hrs, larvae L3    23 Cadmium 50 mM 48 hrs, 4-day adult  (29) Cadmium 100 mM 48 hrs, 4-day adult  (47) Copper 0.5 mM 12 hrs, larvae L3    15 Copper 15 mM 48 hrs, 4-day adult  (40) Zinc 5 mM 12 hrs, larvae L3    14 Zinc 4.5 mM 48 hrs, 4-day adult    24 Ethanol 2.5% 3 hrs, larvae L3  (53) Ethanol 5% 3 hrs, larvae L3    14 Ethanol 10% 3 hrs, larvae L3    15 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (48) Caffeine 25 mg/ml 48 hrs, 4-day adult  (33) Paraquat 5 mM 48 hrs, 4-day adult  (43) Paraquat 10 mM 48 hrs, 4-day adult  (45) Rotenone 2 μg 12 hrs, larvae L3    15 Rotenone 8 μg 12 hrs, larvae L3    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    35 cold shock, 4-day adult    26 heat shock, 4-day adult    31 Cadmium 50 mM 6 hrs, larvae L3    14 Cadmium 50 mM 12 hrs, larvae L3    23 Cadmium 50 mM 48 hrs, 4-day adult    29 Cadmium 100 mM 48 hrs, 4-day adult    47 Copper 0.5 mM 12 hrs, larvae L3    15 Copper 15 mM 48 hrs, 4-day adult    40 Zinc 5 mM 12 hrs, larvae L3    14 Zinc 4.5 mM 48 hrs, 4-day adult    24 Ethanol 2.5% 3 hrs, larvae L3    53 Ethanol 5% 3 hrs, larvae L3    14 Ethanol 10% 3 hrs, larvae L3    15 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    48 Caffeine 25 mg/ml 48 hrs, 4-day adult    33 Paraquat 5 mM 48 hrs, 4-day adult    43 Paraquat 10 mM 48 hrs, 4-day adult    45 Rotenone 2 μg 12 hrs, larvae L3    15 Rotenone 8 μg 12 hrs, larvae L3    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    35 cold shock, 4-day adult    26 heat shock, 4-day adult    31 Cadmium 50 mM 6 hrs, larvae L3    14 Cadmium 50 mM 12 hrs, larvae L3    23 Cadmium 50 mM 48 hrs, 4-day adult    29 Cadmium 100 mM 48 hrs, 4-day adult    47 Copper 0.5 mM 12 hrs, larvae L3    15 Copper 15 mM 48 hrs, 4-day adult    40 Zinc 5 mM 12 hrs, larvae L3    14 Zinc 4.5 mM 48 hrs, 4-day adult    24 Ethanol 2.5% 3 hrs, larvae L3    53 Ethanol 5% 3 hrs, larvae L3    14 Ethanol 10% 3 hrs, larvae L3    15 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    48 Caffeine 25 mg/ml 48 hrs, 4-day adult    33 Paraquat 5 mM 48 hrs, 4-day adult    43 Paraquat 10 mM 48 hrs, 4-day adult    45 Rotenone 2 μg 12 hrs, larvae L3    15 Rotenone 8 μg 12 hrs, larvae L3    15 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    35 cold shock, 4-day adult    26 heat shock, 4-day adult    31 Cadmium 50 mM 6 hrs, larvae L3    14 Cadmium 50 mM 12 hrs, larvae L3    23 Cadmium 50 mM 48 hrs, 4-day adult    29 Cadmium 100 mM 48 hrs, 4-day adult    47 Copper 0.5 mM 12 hrs, larvae L3    15 Copper 15 mM 48 hrs, 4-day adult    40 Zinc 5 mM 12 hrs, larvae L3    14 Zinc 4.5 mM 48 hrs, 4-day adult    24 Ethanol 2.5% 3 hrs, larvae L3    53 Ethanol 5% 3 hrs, larvae L3    14 Ethanol 10% 3 hrs, larvae L3    15 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    48 Caffeine 25 mg/ml 48 hrs, 4-day adult    33 Paraquat 5 mM 48 hrs, 4-day adult    43 Paraquat 10 mM 48 hrs, 4-day adult    45 Rotenone 2 μg 12 hrs, larvae L3    15 Rotenone 8 μg 12 hrs, larvae L3    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (35) cold shock, 4-day adult  26 heat shock, 4-day adult  31 Cadmium 50 mM 6 hrs, larvae L3    14 Cadmium 50 mM 12 hrs, larvae L3    23 Cadmium 50 mM 48 hrs, 4-day adult  29 Cadmium 100 mM 48 hrs, 4-day adult  (47) Copper 0.5 mM 12 hrs, larvae L3    15 Copper 15 mM 48 hrs, 4-day adult  (40) Zinc 5 mM 12 hrs, larvae L3    14 Zinc 4.5 mM 48 hrs, 4-day adult    24 Ethanol 2.5% 3 hrs, larvae L3  (53) Ethanol 5% 3 hrs, larvae L3    14 Ethanol 10% 3 hrs, larvae L3    15 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (48) Caffeine 25 mg/ml 48 hrs, 4-day adult  (33) Paraquat 5 mM 48 hrs, 4-day adult  (43) Paraquat 10 mM 48 hrs, 4-day adult  (45) Rotenone 2 μg 12 hrs, larvae L3    15 Rotenone 8 μg 12 hrs, larvae L3    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    35 cold shock, 4-day adult    26 heat shock, 4-day adult    31 Cadmium 50 mM 6 hrs, larvae L3    14 Cadmium 50 mM 12 hrs, larvae L3    23 Cadmium 50 mM 48 hrs, 4-day adult    29 Cadmium 100 mM 48 hrs, 4-day adult    47 Copper 0.5 mM 12 hrs, larvae L3    15 Copper 15 mM 48 hrs, 4-day adult    40 Zinc 5 mM 12 hrs, larvae L3    14 Zinc 4.5 mM 48 hrs, 4-day adult    24 Ethanol 2.5% 3 hrs, larvae L3    53 Ethanol 5% 3 hrs, larvae L3    14 Ethanol 10% 3 hrs, larvae L3    15 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    48 Caffeine 25 mg/ml 48 hrs, 4-day adult    33 Paraquat 5 mM 48 hrs, 4-day adult    43 Paraquat 10 mM 48 hrs, 4-day adult    45 Rotenone 2 μg 12 hrs, larvae L3    15 Rotenone 8 μg 12 hrs, larvae L3    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    35 cold shock, 4-day adult    26 heat shock, 4-day adult    31 Cadmium 50 mM 6 hrs, larvae L3    14 Cadmium 50 mM 12 hrs, larvae L3    23 Cadmium 50 mM 48 hrs, 4-day adult    29 Cadmium 100 mM 48 hrs, 4-day adult    47 Copper 0.5 mM 12 hrs, larvae L3    15 Copper 15 mM 48 hrs, 4-day adult    40 Zinc 5 mM 12 hrs, larvae L3    14 Zinc 4.5 mM 48 hrs, 4-day adult    24 Ethanol 2.5% 3 hrs, larvae L3    53 Ethanol 5% 3 hrs, larvae L3    14 Ethanol 10% 3 hrs, larvae L3    15 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    48 Caffeine 25 mg/ml 48 hrs, 4-day adult    33 Paraquat 5 mM 48 hrs, 4-day adult    43 Paraquat 10 mM 48 hrs, 4-day adult    45 Rotenone 2 μg 12 hrs, larvae L3    15 Rotenone 8 μg 12 hrs, larvae L3    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_27 mE1_20_mRNA_expression_cluster_02
External Data & Images
Linkouts	BDGP expression data • LD37189 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003744 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8637-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal trcS066917a lethal | embryonic stage trcdsRNA.cGa lethal | embryonic stage | recessive trcS066917a lethal | pupal stage, with Scer\GAL4pnr-MD237 trcGD13993 lethal | recessive trcS066917a viable (with Df(3L)kto2) trc8 Other Phenotypes Allele cell shape defective | somatic clone trcS066917a developmental rate defective | pupal stage (with trc1) trc8 developmental rate defective | pupal stage (with trc8) trc1 neuroanatomy defective trcunspecified neuroanatomy defective | third instar larval stage (with Df(3L)BSC445) trc1 planar polarity defective (with Df(3L)kto2) trc8 planar polarity defective | somatic clone trc1 visible trc8 trcS066917a visible, with Scer\GAL4ap-md544 trcT453A.Scer\UAS visible, with Scer\GAL4ptc-559.1 trcT453A.Scer\UAS visible (with Df(3L)kto2) trc8 visible | recessive | somatic clone trcS066917a visible | somatic clone trcS066917a trcunspecified visible | somatic clone (with trc1) trc8 visible | somatic clone (with trc8) trc1 Phenotype manifest in Allele actin filament | somatic clone trcK23 adult abdominal sensillum (with Df(3L)kto2) trc8 antenna (with trc1) trc8 antenna (with trc8) trc1 arista trc8 trcS066917a arista lateral (with trc1) trc8 arista lateral (with trc8) trc1 dendrite trcunspecified dendrite | cell autonomous | somatic clone | supernumerary trc1 dendritic arborizing neuron trcunspecified denticle trcS066917a denticle (with Df(3L)kto2) trc1 denticle belt (with Df(3L)kto2) trc1 dorsal multidendritic neuron ddaC | third instar larval stage (with Df(3L)BSC445) trc1 egg | somatic clone trc1 trcK23 egg chamber | somatic clone trcK23 follicle cell | somatic clone trcK23 macrochaeta, with Scer\GAL4ap-md544 trcS292A.Scer\UAS trcT453A.Scer\UAS trcS292A+T453A.Scer\UAS macrochaeta, with Scer\GAL4neur-P72 trcS292A.Scer\UAS trcT453A.Scer\UAS trcS292A+T453A.Scer\UAS macrochaeta (with Df(3L)kto2) trc8 multidendritic neuron & dendrite trc1 multidendritic neuron & dendrite, with Scer\GAL4477 trcS292A.T449A.Scer\UAS.T:Zzzz\FLAG trcScer\UAS.T:Zzzz\FLAG trcK122A.Scer\UAS.T:Zzzz\FLAG multidendritic neuron & dendrite | somatic clone trc1 multidendritic neuron & dendrite | supernumerary trc1 multidendritic neuron & dendrite | supernumerary, with Scer\GAL4477 trcS292A.T449A.Scer\UAS.T:Zzzz\FLAG trcScer\UAS.T:Zzzz\FLAG trcK122A.Scer\UAS.T:Zzzz\FLAG trichogen cell (with Df(3L)kto2) trc8 trichome | supernumerary (with Df(3L)kto2) trc8 wing (with Df(3L)kto2) trc8 wing hair | P-stage | cell autonomous | somatic clone | supernumerary trcS066917a wing hair | somatic clone trc1 wing hair | somatic clone | supernumerary trcS066917a trcunspecified wing hair | somatic clone | supernumerary (with trc1) trc8 wing hair | somatic clone | supernumerary (with trc8) trc1 wing hair | supernumerary trcS066917a wing hair | supernumerary, with Scer\GAL4ap-md544 trcS292A.Scer\UAS trcT453A.Scer\UAS trcS292A+T453A.Scer\UAS wing hair | supernumerary, with Scer\GAL4ap-md544, trcS292A.Scer\UAS trcS066917a wing hair | supernumerary, with Scer\GAL4ap-md544, trcS066917a trcS292A.Scer\UAS wing hair | supernumerary, with Scer\GAL4ptc-559.1 trcT453A.Scer\UAS wing hair | supernumerary (with Df(3L)kto2) trc8 wing hair | supernumerary (with trcS292A.Scer\UAS), with Scer\GAL4ap-md544 trcS066917a wing hair | supernumerary (with trcS066917a), with Scer\GAL4ap-md544 trcS292A.Scer\UAS
Classical Alleles ( 11 )
For All Classical Alleles Show
Allele of trc Class Mutagen Stocks Known lesion trc1 loss of function allele ethyl methanesulfonate 4 Yes trcS022204 P-element activity 1 -- trcS066917a Delta2-3 P-element activity 1 Yes trc2 loss of function allele 0 Yes trc3 0 -- trc4 0 Yes trc5 0 Yes trc6 0 Yes trc8 hypomorphic allele - genetic evidence P-element activity 0 Yes trcK23 ethyl methanesulfonate 0 Yes trcunspecified 0 --
Alleles Carried on Transgenic Constructs ( 24 )
For All Alleles Carried on Transgenic Constructs Show
Allele of trc Class Mutagen Stocks Known lesion trcS292A.Scer\UAS in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 2 Yes trcS292E.Scer\UAS in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 2 Yes trcScer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 2 Yes trcT453A.Scer\UAS in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 2 Yes trcGD13993 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes trcGL00028 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes trcGL01127 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes trcJF02961 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes trcK122A+T453A.Scer\UAS in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 1 Yes trcK122A.Scer\UAS.T:Zzzz\FLAG in vitro construct - site directed mutagenesis in vitro construct - regulatory fusion in vitro construct - amino acid replacement 1 Yes trcKK109419 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes trcL.Scer\UAS in vitro construct - regulatory fusion 1 Yes trcS292A+T453A.Scer\UAS in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 1 Yes trcshort.Scer\UAS in vitro construct - regulatory fusion 1 Yes trcT453E.Scer\UAS in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 1 Yes trcdsRNA.cGa in vitro construct - RNAi 0 Yes trcMtnA.PC in vitro construct - regulatory fusion 0 Yes trcNIG.8637R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes trcS292A.T449A.Scer\UAS.T:Zzzz\FLAG in vitro construct - site directed mutagenesis 0 Yes trcScer\UAS.cUa in vitro construct - regulatory fusion 0 Yes trcScer\UAS.T:Myr-Src64B in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes trcScer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion 0 Yes trct19 in vitro construct - genomic fragment 0 Yes trcT449A.Scer\UAS.T:Myr-Src64B in vitro construct - amino acid replacement 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)25-21 (Veraksa et al., 2002, Cooper et al., 2010) Df(3L)A23 (Cooper et al., 2010) Df(3L)ash1A16 (Cooper et al., 2010) Df(3L)BSC2 (Cooper et al., 2010) Df(3L)BSC445 (Cooper et al., 2010) Df(3L)ED228 (Cooper et al., 2010) Df(3L)Exel9007 (Cooper et al., 2010) Df(3L)Exel9008 (Cooper et al., 2010) Df(3L)Exel9009 (Cooper et al., 2010) Df(3L)kto2 (Szeged Stock Center, 1998-, Geng et al., 2000, Veraksa et al., 2002, Zhu et al., 2005, Cooper et al., 2010) Df(3L)kto22 (Cooper et al., 2010) Df(3L)XS533 (Cooper et al., 2010) Df(3L)XS543 (Cooper et al., 2010) Df(3L)XS572 (Cooper et al., 2010) Df(3L)XS705 (Cooper et al., 2010) Df(3L)XS917 (Cooper et al., 2010) Df(3L)XS2182 (Cooper et al., 2010)
Not disrupted in	Df(3L)BSC20 (Cooper et al., 2010) Df(3L)BSC417 (Cooper et al., 2010) Df(3L)ED4799 (Cooper et al., 2010) Df(3L)ED4858 (Cooper et al., 2010) Df(3L)Exel6135 (Cooper et al., 2010) Df(3L)Exel9011 (Cooper et al., 2010) Df(3L)Exel9045 (Cooper et al., 2010) Df(3L)Exel9046 (Cooper et al., 2010) Df(3L)pipeA13 (Cooper et al., 2010) Df(3L)VW3 (Szeged Stock Center, 1998-) Df(3L)XS411 (Cooper et al., 2010)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD13993} NA P{KK109419} NA P{NIG.8637R} NA P{TRiP.GL00028} NA P{TRiP.GL01127} NA P{TRiP.JF02961} NA P{UAS-trc.FLAG} NA P{UAS-trc.K122A} NA P{UAS-trc.K122A+T453A} NA P{UAS-trc.L} NA P{UAS-trc.Myr.T449A} NA P{UAS-trc.Myr} NA P{UAS-trc.S292A.T449A.FLAG} NA P{UAS-trc.S292A} NA P{UAS-trc.S292A+T453A} NA P{UAS-trc.S292E} NA P{UAS-trc.short} NA P{UAS-trc.T453A} NA P{UAS-trc.T453E} NA P{UAS-trc.U} NA P{UAS-trc-GFP} NA characterization construct P{C4D1R} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}trcS022204 No P{lacW}trcS066917a No miscellaneous insertions P{?lacW}trc8 NA
Gene Ontology: Function, Process & Cellular Component ( 15 unique terms )
Terms Based on Experimental Evidence ( 12 terms )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with fry (He et al., 2005) inferred from physical interaction with UniProtKB:Q95RA8 (assigned by UniProtKB) (He et al., 2005)
Biological Process
CV term Evidence References
antennal morphogenesis inferred from mutant phenotype (He and Adler, 2002) chaeta development inferred from mutant phenotype (He et al., 2005) dendrite morphogenesis inferred from mutant phenotype (Grueber et al., 2007) dendrite self-avoidance inferred from genetic interaction with stan (Matsubara et al., 2011) imaginal disc-derived wing hair organization inferred from mutant phenotype (Cong et al., 2001, He et al., 2005) imaginal disc-derived wing morphogenesis inferred from mutant phenotype (Cong et al., 2001) regulation of dendrite morphogenesis inferred from mutant phenotype (Emoto et al., 2004) signal transduction inferred from mutant phenotype (assigned by UniProtKB) (He et al., 2005)
Cellular Component
CV term Evidence References
cell cortex inferred from direct assay (He et al., 2005) cytoplasm inferred from direct assay (He et al., 2005, Horne-Badovinac et al., 2012) inferred from direct assay (assigned by UniProtKB) (He et al., 2005) nucleus inferred from direct assay (Horne-Badovinac et al., 2012) inferred from direct assay (assigned by UniProtKB) (He et al., 2005)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR000961, InterPro:IPR002290, InterPro:IPR017441, InterPro:IPR017892 (FlyBase Curators et al., 2004-) protein serine/threonine kinase activity inferred from sequence or structural similarity (Millward et al., 1995) inferred from sequence or structural similarity with UniProtKB:O13310 (FlyBase, 1992-) non-traceable author statement (Millward, 1994.7.6, Geng, 2000.2.22, Adler, 2000.3.21, Morrison et al., 2000)
Biological Process
CV term Evidence References
protein phosphorylation inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR000961, InterPro:IPR002290, InterPro:IPR008271, InterPro:IPR017892 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Millward et al., 1995) non-traceable author statement (Morrison et al., 2000)
Cellular Component
CV term Evidence References
nucleus inferred from sequence or structural similarity (Millward et al., 1995) non-traceable author statement (Millward, 1994.7.6)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
trc - Gp210 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) trc - Jupiter anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) trc - Saf-B anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) trc - mRpS24 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions trc allele Gene References trcK122A.Scer\UAS.T:Zzzz\FLAG Rac1 (Emoto et al., 2004) trcScer\UAS.T:Zzzz\FLAG Rac1 (Emoto et al., 2004) unspecified bsk (He et al., 2005) Cdc42 (He et al., 2005) fry (He et al., 2005) Graf (He et al., 2005) mats (He et al., 2005) Rac1 (He et al., 2005) Rala (He et al., 2005) Rho1 (He et al., 2005) vimar (He et al., 2005) wts (He et al., 2005)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 65434 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0003744 DroID - A comprehensive database of gene and protein interactions. • FBgn0003744 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40165 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q9NBK5
Orthologs
OrthoDB Orthologs (44) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6SXNZ7 Dipteran inclusive ortholog search EOG6VT65M Insect inclusive ortholog search EOG6BP072 Arthropod inclusive ortholog search EOG6G4F5P Metazoa inclusive ortholog search EOG6WHND0
Orthologs in Drosophila Species (EOG6SXNZ7)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\trc     Drosophila simulans   Dsim\GD12245 Y   Drosophila sechellia   Dsec\GM16004 Y   Drosophila erecta   Dere\GG13366 Y   Drosophila yakuba   Dyak\GE22460 Y   Drosophila ananassae   Dana\GF10844 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA21227 Y   Drosophila persimilis   Dper\GL15676 Y   Drosophila willistoni   Dwil\GK17215 Y   Drosophila virilis   Dvir\GJ14000 Y   Drosophila mojavensis   Dmoj\GI13665 Y   Drosophila grimshawi   Dgri\GH16909 Y
Orthologs in non-Drosophila Dipterans (EOG6VT65M)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL014849   Aedes aegypti Yellow fever mosquito  Aaeg\AAEL010021   Anopheles gambiae Malaria mosquito  Agam\AGAP005521
Orthologs in non-Dipteran Insects (EOG6BP072)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB53582   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG012909   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH16229   Atta cephalotes Leafcutter ant  Acep\ACEP16701   Camponotus floridanus Florida carpenter ant  Cflo\CFLO17113   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL14185   Linepithema humile Argentine ant  Lhum\LH16438   Pogonomyrmex barbatus Red harvester ant  Pbar\PB24098   Solenopsis invicta Red fire ant  Sinv\SINV17305   Acyrthosiphon pisum Pea aphid  Apim\ACYPI004168   Bombyx mori Silkmoth  Bmor\BGIBMGA003858   Pediculus humanus Human body louse  Phum\PHUM581950   Tribolium castaneum Red flour beetle  Tcas\TC002475
Orthologs in non-Insect Arthropods (EOG6G4F5P)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_308031   Ixodes scapularis Deer tick  Isca\ISCW017707
Orthologs in non-Arthropod Metazoa (EOG6WHND0)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\sax-1   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_012503gn   Danio rerio Zebrafish  Drer\stk38l   Danio rerio Zebrafish  Drer\ENSDARG00000018516   Danio rerio Zebrafish  Drer\DKEY-48J7.4   Xenopus tropicalis Western clawed frog  Xtro\stk38l   Xenopus tropicalis Western clawed frog  Xtro\stk38   Gallus gallus Domestic chicken  Ggal\STK38   Gallus gallus Domestic chicken  Ggal\STK38L   Mus musculus House mouse  Mmus\Stk38l   Mus musculus House mouse  Mmus\Stk38   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000001828   Rattus norvegicus Norway rat  Rnor\Stk38   Homo sapiens Human  Hsap\STK38
Human Orthologs (1)
Gene OMIM HGNC Hsap\STK38
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD12245 Drosophila sechellia Dsec\GM16004 Drosophila erecta Dere\GG13366 Drosophila yakuba Dyak\GE22460 Drosophila ananassae Dana\GF10844 Drosophila pseudoobscura pseudoobscura Dpse\GA21227 Drosophila persimilis Dper\GL15676 Drosophila willistoni Dwil\GK17215 Drosophila virilis Dvir\GJ14000 Drosophila mojavensis Dmoj\GI13665 Drosophila grimshawi Dgri\GH16909
Stocks & Reagents
Stocks Listed in FlyBase ( 25 )
Bloomington	32085 w*; P{UAS-trc.L}3 32090 w*; P{UAS-trc-GFP}2 32080 w*; P{UAS-trc.short}3 32083 w*; P{UAS-trc.T453A}2 32084 w*; P{UAS-trc.S292A}2 32088 w*; P{UAS-trc.T453A}3 32089 w*; P{UAS-trc.T453E}3 32091 w*; P{UAS-trc.S292E}3 32081 w*; P{UAS-trc.S292E}2/CyO 32082 w*; P{UAS-trc.K122A}2/CyO
VDRC	v107923 P{KK109419}VIE-260B v35988 w1118; P{GD13993}v35988/CyO
	More stocks available...
Genomic Clones ( 1 )
	BACR01B21 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 61 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD37189
Other clones	DPiM_LD37189
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT02843 AT20155 AT21389 AT23647 GH16329 GH24041 GM10763 LD15101 LP06419 RE10210 RE32130 RE33605 RE34159 RE59506 RH42717 RH44088 RH46167
Other clones	9000 10877 16006 17897.2 29760 42219 52690 65003 73881 79555 104713 147431 161987 166259 214307.38 277675 CK01.6D.C4 CK01.64B.E9 EC051305 EC052342 EC052378 EC053332 EC056289 EC056455 EK010132 EK065117 EK066507 EK107954 EK125832 EK125833 EK137919 EK168119 EK174015 EK177331 EK191656 EK209849 EK213608 EK249912 EK304724 EK307306 ESG018b.E21.1_H04 FGH126H06
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0003744 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40165
Antibody Information
	polyclonal (Koike-Kumagai et al., 2009)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: trc CG8637 (FlyBase, 1996-)
Source for database merge of	Source for merge of: trc l(3)S066917 (Geng et al., 2000)
Additional comments	Source for identity of trc CG8637 was sequence comparison (date:000504). (FlyBase, 1996-)
Other Comments
	dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) trc is important for maintaining the integrity of outgrowths of epidermal cells. (Geng et al., 2000) Mutations in trc result in the splitting or branching of cuticular structures produced by cytoskeletal-mediated outgrowths of epidermal cells (the adult epidermal hairs, the shafts of adult sense organs, the lateral extensions of the arista and the larval denticles). (Geng et al., 2000) Mutants do not exhibit defects in the denticle belt of hairs of the larvae. (Dickinson and Thatcher, 1997) cDNA clone encoding the homologue of human Ndr has been isolated and sequenced. (Millward et al., 1995) Mutant alleles are useful as markers in clonal analysis. (Lawrence et al., 1986)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079446 NM_001275142 RefSeq (Proteins) • NP_524170 NP_001262071 DDBJ / EMBL / GenBank • AA440026 AAF49104 AAF67167 AAF67168 AAF97511 AAK93304 AF238490 AF239171 AF247814 AGB94764 AI257917 AI293206 AI404371 AI456993 AW943372 AY051880 CAA84486 Z35103 Entrez Gene - A searchable database of RefSeq genes. • 40165 UniProtKB/Swiss-Prot • Q9NBK5
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) AGC-kinase, C-terminal (IPR000961) Serine/threonine- / dual specificity protein kinase, catalytic domain (IPR002290) Serine/threonine-protein kinase, active site (IPR008271) Protein kinase-like domain (IPR011009) Protein kinase, ATP binding site (IPR017441) Protein kinase, C-terminal (IPR017892) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD37189
Linkouts
	BioGRID - A database of protein and genetic interactions • 65434 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0003744 DroID - A comprehensive database of gene and protein interactions. • FBgn0003744 DRSC - Results from RNAi screens. • FBgn0003744 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003744 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8637-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0003744 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40165 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /hjmuller/tricornered1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40165 modMine - Data generated by the modENCODE project. • FBgn0003744 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q9NBK5
Synonyms & Secondary IDs ( 14 )
Reported As
Symbol Synonym	0669/17 (Deak et al., 1997) CG8637 (Morrison et al., 2000, Keleman et al., 2009.8.5, Perkins et al., 2009, Ni et al., 2011.7.19, Ni et al., 2010.12.1) dmTRC (Tamaskovic et al., 2003) l(3)76BDa (Cooper et al., 2010) l(3)S066917   NDR (Morrison et al., 2000, Bassett et al., 1997) Ndr (Millward, 1994.7.6, Millward et al., 1995, ) RE-D (Horne-Badovinac et al., 2012) trc (Fang and Adler, 2007, Zinn, 2004, He et al., 2005, He et al., 2005, Fei et al., 2002, Horne-Badovinac et al., 2012, Cukier et al., 2008, Grueber et al., 2007, Soba et al., 2007, Koike-Kumagai et al., 2009, Long et al., 2009, Fang and Adler, 2010, Fang et al., 2010, Cooper et al., 2010, Adler, 2010.9.10, Beltran et al., 2007, Hogan et al., 2011, Matsubara et al., 2011, Han et al., 2012, Japanese National Institute of Genetics, 2012.5.21) Trc (He et al., 2005, Emoto et al., 2006, Cully et al., 2010)
Name Synonym	Nuclear Dbf2-related protein kinase   tricorner (Adler, 2000.3.21, Lindsley and Zimm, 1992) tricornered (Chanut-Delalande et al., 2006, Fang and Adler, 2007, Edgar, 2006, Zinn, 2004, Fei et al., 2002, Cukier et al., 2008, Koike-Kumagai et al., 2009, Fang and Adler, 2010, Hogan et al., 2011) Tricornered (He et al., 2005, Emoto et al., 2006, Long et al., 2009, Fang et al., 2010)
Secondary FlyBase IDs
	FBgn0014866 FBgn0028111
References ( 79 )
Generate a list of	All references relating to this gene ( 79 )
List References by type	Research paper  ( 38 ) Supplementary material  ( 6 ) Review  ( 7 ) Personal communication to FlyBase  ( 11 ) Abstract  ( 5 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 3 ) Book  ( 1 ) Stock list  ( 2 ) Website  ( 1 ) Curated genome annotation  ( 2 ) Thesis  ( 1 )
Recent research papers ( 5 )
	Wu et al., 2013, Genes Dev. 27(2): 157--162 Tricornered/NDR kinase signaling mediates PINK1-directed mitochondrial quality control and tissue maintenance. [FBrf0220987] Han et al., 2012, Neuron 73(1): 64--78 Integrins Regulate Repulsion-Mediated Dendritic Patterning of Drosophila Sensory Neurons by Restricting Dendrites in a 2D Space. [FBrf0217239] Horne-Badovinac et al., 2012, G3 (Bethesda) 2(3): 371--378 A screen for round egg mutants in Drosophila identifies tricornered, furry, and misshapen as regulators of egg chamber elongation. [FBrf0217749] Hogan et al., 2011, PLoS Genet. 7(2): e1001305 Two frizzled planar cell polarity signals in the Drosophila wing are differentially organized by the fat/dachsous pathway. [FBrf0213159] Matsubara et al., 2011, Genes Dev. 25(18): 1982--1996 The seven-pass transmembrane cadherin Flamingo controls dendritic self-avoidance via its binding to a LIM domain protein, Espinas, in Drosophila sensory neurons. [FBrf0215818] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...