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Gene Dmel\Gr5a

General Information
Symbol	Dmel\Gr5a	Species	D. melanogaster
Name	Gustatory receptor 5a	Annotation symbol	CG15779
Feature type	protein_coding_gene	FlyBase ID	FBgn0003747
Gene Model Status	Current	Stock availability	5 publicly available
Also Known As	tre, Gr5A1
Genomic Location
Chromosome (arm)	X	Recombination map	1-13.6
Cytogenetic map	5A12-5A12	Sequence location	X:5,574,650..5,576,521 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Gustatory receptor 5a is referred to in FlyBase by the symbol Dmel\Gr5a (CG15779, FBgn0003747). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: taste receptor activity; sweet taste receptor activity. There is experimental evidence that it is involved in the biological process: detection of chemical stimulus involved in sensory perception of taste; response to trehalose stimulus; proboscis extension reflex; sensory perception of sweet taste; sensory perception of taste. 72 alleles are reported. The phenotypes of these alleles are annotated with: large labellar taste bristle; labellar taste bristle. It has one annotated transcript and one annotated polypeptide. Protein features are: Trehalose receptor. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of low expression to a trough of no expression detected. Peak expression observed during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: No expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1632407_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Tre. Gene sequence location is X:5574650..5576521.
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	Tre: Trehalose sensitivity (J.C. Hall) Locus determining differences in sensitivity to the taste of the disaccharide trehalose in behaviorly-based (fluid intake) tests (no differences in sensitivity to glucose, fructose, or sucrose). The Tre+ allele results in high trehalose sensitivity, the Tre allele in low trehalose sensitivity. Females with half the normal dose of a given Tre+ allele are half as sensitive to trehalose, but flies (male or female) with twice the normal dose of Tre+ show only a slight increase in sensitivity as compared to normal flies. Tre is thought to be a structural gene for the trehalose specific receptor in D. melanogaster (Tanimura et al., 1988).
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	References Park and Kwon, 2011, Mol. Cells 32(4): 375--381
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 5A12-5A12   Limits computationally determined from genome sequence between P{EP}Tre1EP496 and P{EP}cvEP1349&P{EP}CG32758EP1368
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location	1-13.6   1- (Tanimura et al., 1982)
Left of (cM)	m (Tanimura et al., 1982)
Right of (cM)
Notes	Closely linked to cx. (Tanimura et al., 1982)
Gene Model & Products
Please see the GBrowse view of Dmel\Gr5a for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.42
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Gr5a-RA FBtr0070802  NM_078495   1490   444
Additional Transcript Data & Comments
Reported size (kB)	1.179 (longest cDNA) (Ishimoto et al., 2000)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Gr5a-PA   FBpp0070768   51.2   444   9.94     NP_511050   AAF46060
Additional Polypeptide Data & Comments
Reported size (kDa)	392 (aa) (Ishimoto et al., 2000)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Trehalose receptor (IPR009318)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014298 AAF46060   AB066610   AB066611   AB066612   AB066619 BAB68243   AB066620 BAB68244   AB066621 BAB68245   AB066622 BAB68246   AB066623 BAB68247   AB066624 BAB68248   AB066625 BAB68249   AB066626 BAB68250   AB066627 BAB68251   AB066628 BAB68252   AB066629 BAB68253   AB066630 BAB68254   AB066631 BAB68255   AB066632 BAB68256   AB066633 BAB68257   AB066634 BAB68258   AB066635 BAB68259   AB066636 BAB68260   AB066637 BAB68261   AB066638 BAB68262   AB066639 BAB68263   AB066640 BAB68264   AB066641 BAB68265   AB066642 BAB68266   AB066643 BAB68267   AB162449 BAD42667   AB162450 BAD42668   AB162451 BAD42669   AB162452 BAD42670   AB162453 BAD42671   AB162454 BAD42672   AB162455 BAD42673   AB162456 BAD42674   AB162457 BAD42675   AB162458 BAD42676   AB162459 BAD42677   AB162460 BAD42678   AB162461 BAD42679   AB162462 BAD42680   AB162463 BAD42681   AB162464 BAD42682   AB162465 BAD42683   AB162466 BAD42684   AB162467 BAD42685   AB162468 BAD42686   AB162469 BAD42687   AB162470 BAD42688   AB162471 BAD42689   AB162472 BAD42690   AB162473 BAD42691   AB162474 BAD42692   AB162475 BAD42693   AB162476 BAD42694   AB162477 BAD42695   AB162478 BAD42696   AB162479 BAD42697   AB162480 BAD42698   AB162481 BAD42699   AB162482 BAD42700   AB162483 BAD42701   AB162484 BAD42702   AB162485 BAD42703   AB162486 BAD42704   AB162487 BAD42705   AB162488 BAD42706   AB162489 BAD42707   AB162490 BAD42708   AB162491 BAD42709   AB162492 BAD42710   AB162493 BAD42711   AB162494 BAD42712   AB162495 BAD42713   AB162496 BAD42714   AB162497 BAD42715   AB162498 BAD42716   AB162499 BAD42717   AB162500 BAD42718   AB162501 BAD42719   AB162502 BAD42720   AB162503 BAD42721   AB162504 BAD42722   AB162505 BAD42723   AB162506 BAD42724   AB162507 BAD42725   AB162508 BAD42726   AB162509 BAD42727   AB162510 BAD42728   AB162511 BAD42729   AB162512 BAD42730   AB162513 BAD42731   AB162514 BAD42732   AB162515 BAD42733   AB162516 BAD42734   AB162517 BAD42735   AB162518 BAD42736   AB162519 BAD42737   AB162520 BAD42738   AB162521 BAD42739   AB162522 BAD42740   AB162523 BAD42741   AB162524 BAD42742   AB162525 BAD42743   AB162526 BAD42744   AB162527 BAD42745   AB162528 BAD42746   AB162529 BAD42747   AB162530 BAD42748   AB162531 BAD42749   AB162532 BAD42750   AB162533 BAD42751   AB162534 BAD42752   AB162535 BAD42753   AB162536 BAD42754   AB162537 BAD42755   AB162538 BAD42756   AB162539 BAD42757   AB162540 BAD42758   AB162541 BAD42759   AB162542 BAD42760   AB162543 BAD42761   AB162544 BAD42762   AB162545 BAD42763   AB162546 BAD42764   AB162547 BAD42765   AB162548 BAD42766   AB162549 BAD42767   AB162550 BAD42768   AB162551 BAD42769   AB162552 BAD42770   AB162553 BAD42771   AB162554 BAD42772   AB162555 BAD42773   AB162556 BAD42774   AB162557 BAD42775   AB162558 BAD42776   AB162559 BAD42777   AB162560 BAD42778   AB162561 BAD42779   AB162562 BAD42780   AB162563 BAD42781   AB162564 BAD42782   AB162565 BAD42783   AB162566 BAD42784   AB162567 BAD42785   AB162568 BAD42786   AB162569 BAD42787   AB162570 BAD42788   AB162571 BAD42789   AB162572 BAD42790   AB162573 BAD42791   AB162574 BAD42792   AB162575 BAD42793   AB162576 BAD42794   AB162577 BAD42795   AB162578 BAD42796   AB162579 BAD42797   AB162580 BAD42798   AB162581 BAD42799   AB162582 BAD42800   AB162583 BAD42801   AB162584 BAD42802   AB162585 BAD42803   AB162586 BAD42804   AB162587 BAD42805   AB162588 BAD42806   AB162589 BAD42807   AB162590 BAD42808   AB162591 BAD42809   AB162592 BAD42810   AB162593 BAD42811   AB162594 BAD42812   AB162595 BAD42813   AB162596 BAD42814   AB162597 BAD42815   AB162598 BAD42816   AB162599 BAD42817   AB162600 BAD42818   AB162601 BAD42819   AB162602 BAD42820   AB162603 BAD42821   AB162604 BAD42822   AB162605 BAD42823   AB162606 BAD42824   AB162607 BAD42825   AB162608 BAD42826   AB162609 BAD42827   AB162610 BAD42828   AB162611 BAD42829   AB162612 BAD42830   AX058703 CAC22536   BT023064   BT023109   BT023120   CO313489   EC202699
UniProtKB/Swiss-Prot	Q9W497
UniProtKB/TrEMBL	Q68AZ6 Q68AZ7 Q68AZ8 Q68AZ9 Q68B00 Q68B02 Q68B03 Q68B04 Q68B06
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference adult stage   gustatory sensory organ   (Ishimoto et al., 2000)
Additional Descriptive Data
	In-situ hybridization to labellum preparations show that Tre1 transcript is present in one of the taste sensory cells beneath a taste bristle. (Ishimoto et al., 2000)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0003747    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0003747 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of low expression to a trough of no expression detected. Peak expression observed during early pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0003747 expression level Developmental Stage   Expression Level embryo 00-02hr    7 embryo 02-04hr    44 embryo 04-06hr    60 embryo 06-08hr    25 embryo 08-10hr    24 embryo 10-12hr    32 embryo 12-14hr    20 embryo 14-16hr    17 embryo 16-18hr    6 embryo 18-20hr    7 embryo 20-22hr    7 embryo 22-24hr    8 larva L1    4 larva L2    3 larva L3 12hr old    0 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    43 white prepupae new    142 white prepupae 12hr    9 white prepupae 24hr    10 pupae 2d postWPP    8 pupae 3d postWPP    12 pupae 4d postWPP    14 adult male 01day    19 adult male 05day    21 adult male 30day    31 adult female 01day    8 adult female 05day    16 adult female 30day    9 Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    7 embryo 02-04hr    44 embryo 04-06hr    60 embryo 06-08hr    25 embryo 08-10hr    24 embryo 10-12hr    32 embryo 12-14hr    20 embryo 14-16hr    17 embryo 16-18hr    6 embryo 18-20hr    7 embryo 20-22hr    7 embryo 22-24hr    8 larva L1    4 larva L2    3 larva L3 12hr old    0 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    43 white prepupae new  (142) white prepupae 12hr    9 white prepupae 24hr    10 pupae 2d postWPP    8 pupae 3d postWPP    12 pupae 4d postWPP    14 adult male 01day    19 adult male 05day    21 adult male 30day    31 adult female 01day    8 adult female 05day    16 adult female 30day    9 Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    7 embryo 02-04hr    44 embryo 04-06hr    60 embryo 06-08hr    25 embryo 08-10hr    24 embryo 10-12hr    32 embryo 12-14hr    20 embryo 14-16hr    17 embryo 16-18hr    6 embryo 18-20hr    7 embryo 20-22hr    7 embryo 22-24hr    8 larva L1    4 larva L2    3 larva L3 12hr old    0 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    43 white prepupae new    142 white prepupae 12hr    9 white prepupae 24hr    10 pupae 2d postWPP    8 pupae 3d postWPP    12 pupae 4d postWPP    14 adult male 01day    19 adult male 05day    21 adult male 30day    31 adult female 01day    8 adult female 05day    16 adult female 30day    9 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    7 embryo 02-04hr    44 embryo 04-06hr    60 embryo 06-08hr    25 embryo 08-10hr    24 embryo 10-12hr    32 embryo 12-14hr    20 embryo 14-16hr    17 embryo 16-18hr    6 embryo 18-20hr    7 embryo 20-22hr    7 embryo 22-24hr    8 larva L1    4 larva L2    3 larva L3 12hr old    0 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    43 white prepupae new    142 white prepupae 12hr    9 white prepupae 24hr    10 pupae 2d postWPP    8 pupae 3d postWPP    12 pupae 4d postWPP    14 adult male 01day    19 adult male 05day    21 adult male 30day    31 adult female 01day    8 adult female 05day    16 adult female 30day    9 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    7 embryo 02-04hr    44 embryo 04-06hr    60 embryo 06-08hr    25 embryo 08-10hr    24 embryo 10-12hr    32 embryo 12-14hr    20 embryo 14-16hr    17 embryo 16-18hr    6 embryo 18-20hr    7 embryo 20-22hr    7 embryo 22-24hr    8 larva L1    4 larva L2    3 larva L3 12hr old    0 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    43 white prepupae new    142 white prepupae 12hr    9 white prepupae 24hr    10 pupae 2d postWPP    8 pupae 3d postWPP    12 pupae 4d postWPP    14 adult male 01day    19 adult male 05day    21 adult male 30day    31 adult female 01day    8 adult female 05day    16 adult female 30day    9 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0003747 expression level Developmental Stage   Expression Level embryo 00-02hr    7 embryo 02-04hr    44 embryo 04-06hr    60 embryo 06-08hr    25 embryo 08-10hr    24 embryo 10-12hr    32 embryo 12-14hr    20 embryo 14-16hr    17 embryo 16-18hr    6 embryo 18-20hr    7 embryo 20-22hr    7 embryo 22-24hr    8 larva L1    4 larva L2    3 larva L3 12hr old    0 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    43 white prepupae new    142 white prepupae 12hr    9 white prepupae 24hr    10 pupae 2d postWPP    8 pupae 3d postWPP    12 pupae 4d postWPP    14 adult male 01day    19 adult male 05day    21 adult male 30day    31 adult female 01day    8 adult female 05day    16 adult female 30day    9 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    7 embryo 02-04hr    44 embryo 04-06hr    60 embryo 06-08hr    25 embryo 08-10hr    24 embryo 10-12hr    32 embryo 12-14hr    20 embryo 14-16hr    17 embryo 16-18hr    6 embryo 18-20hr    7 embryo 20-22hr    7 embryo 22-24hr    8 larva L1    4 larva L2    3 larva L3 12hr old    0 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    43 white prepupae new  142 white prepupae 12hr    9 white prepupae 24hr    10 pupae 2d postWPP    8 pupae 3d postWPP    12 pupae 4d postWPP    14 adult male 01day    19 adult male 05day    21 adult male 30day    31 adult female 01day    8 adult female 05day    16 adult female 30day    9 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    7 embryo 02-04hr    44 embryo 04-06hr    60 embryo 06-08hr    25 embryo 08-10hr    24 embryo 10-12hr    32 embryo 12-14hr    20 embryo 14-16hr    17 embryo 16-18hr    6 embryo 18-20hr    7 embryo 20-22hr    7 embryo 22-24hr    8 larva L1    4 larva L2    3 larva L3 12hr old    0 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    43 white prepupae new    142 white prepupae 12hr    9 white prepupae 24hr    10 pupae 2d postWPP    8 pupae 3d postWPP    12 pupae 4d postWPP    14 adult male 01day    19 adult male 05day    21 adult male 30day    31 adult female 01day    8 adult female 05day    16 adult female 30day    9 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    7 embryo 02-04hr    44 embryo 04-06hr    60 embryo 06-08hr    25 embryo 08-10hr    24 embryo 10-12hr    32 embryo 12-14hr    20 embryo 14-16hr    17 embryo 16-18hr    6 embryo 18-20hr    7 embryo 20-22hr    7 embryo 22-24hr    8 larva L1    4 larva L2    3 larva L3 12hr old    0 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    43 white prepupae new    142 white prepupae 12hr    9 white prepupae 24hr    10 pupae 2d postWPP    8 pupae 3d postWPP    12 pupae 4d postWPP    14 adult male 01day    19 adult male 05day    21 adult male 30day    31 adult female 01day    8 adult female 05day    16 adult female 30day    9 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    7 embryo 02-04hr    44 embryo 04-06hr    60 embryo 06-08hr    25 embryo 08-10hr    24 embryo 10-12hr    32 embryo 12-14hr    20 embryo 14-16hr    17 embryo 16-18hr    6 embryo 18-20hr    7 embryo 20-22hr    7 embryo 22-24hr    8 larva L1    4 larva L2    3 larva L3 12hr old    0 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    43 white prepupae new    142 white prepupae 12hr    9 white prepupae 24hr    10 pupae 2d postWPP    8 pupae 3d postWPP    12 pupae 4d postWPP    14 adult male 01day    19 adult male 05day    21 adult male 30day    31 adult female 01day    8 adult female 05day    16 adult female 30day    9 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0003747    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0003747 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: No expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0003747 expression level Tissue   Expression Level Larval Central Nervous System    5.95 Larval Midgut    7.9 Larval Hindgut    3.7 Larval Malpighian Tubules    4.6 Larval Fat Body    6.8 Larval Salivary Gland    4.4 Larval Trachea    3.65 Larval Carcass    6.375 Adult Head    5.7 Adult Eye    3.1 Adult Brain    5.1 Adult Thoracic-Abdominal Ganglion    4.3 Adult Crop    4.8 Adult Midgut no informative data Adult Hindgut    4.8 Adult Malpighian Tubules    5.2 Adult Fat Body    6.1 Adult Salivary Gland    9 Adult Heart    6.475 Adult VirginFemale Spermatheca    8.8 Adult InseminatedFemale Spermatheca    4.9 Adult Ovary    2.5 Adult Testis    2.1 Adult Male Accessory Gland    5.6 Adult Carcass no informative data Expression Level Scale  None   Low  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    5.95 Larval Midgut    7.9 Larval Hindgut    3.7 Larval Malpighian Tubules    4.6 Larval Fat Body    6.8 Larval Salivary Gland    4.4 Larval Trachea    3.65 Larval Carcass    6.375 Adult Head    5.7 Adult Eye    3.1 Adult Brain    5.1 Adult Thoracic-Abdominal Ganglion    4.3 Adult Crop    4.8 Adult Midgut no informative data Adult Hindgut    4.8 Adult Malpighian Tubules    5.2 Adult Fat Body    6.1 Adult Salivary Gland    9 Adult Heart    6.475 Adult VirginFemale Spermatheca    8.8 Adult InseminatedFemale Spermatheca    4.9 Adult Ovary    2.5 Adult Testis    2.1 Adult Male Accessory Gland    5.6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    5.95 Larval Midgut    7.9 Larval Hindgut    3.7 Larval Malpighian Tubules    4.6 Larval Fat Body    6.8 Larval Salivary Gland    4.4 Larval Trachea    3.65 Larval Carcass    6.375 Adult Head    5.7 Adult Eye    3.1 Adult Brain    5.1 Adult Thoracic-Abdominal Ganglion    4.3 Adult Crop    4.8 Adult Midgut no informative data Adult Hindgut    4.8 Adult Malpighian Tubules    5.2 Adult Fat Body    6.1 Adult Salivary Gland    9 Adult Heart    6.475 Adult VirginFemale Spermatheca    8.8 Adult InseminatedFemale Spermatheca    4.9 Adult Ovary    2.5 Adult Testis    2.1 Adult Male Accessory Gland    5.6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    5.95 Larval Midgut    7.9 Larval Hindgut    3.7 Larval Malpighian Tubules    4.6 Larval Fat Body    6.8 Larval Salivary Gland    4.4 Larval Trachea    3.65 Larval Carcass    6.375 Adult Head    5.7 Adult Eye    3.1 Adult Brain    5.1 Adult Thoracic-Abdominal Ganglion    4.3 Adult Crop    4.8 Adult Midgut no informative data Adult Hindgut    4.8 Adult Malpighian Tubules    5.2 Adult Fat Body    6.1 Adult Salivary Gland    9 Adult Heart    6.475 Adult VirginFemale Spermatheca    8.8 Adult InseminatedFemale Spermatheca    4.9 Adult Ovary    2.5 Adult Testis    2.1 Adult Male Accessory Gland    5.6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0003747 expression level Tissue   Expression Level Larval Central Nervous System    5.95 Larval Midgut    7.9 Larval Hindgut    3.7 Larval Malpighian Tubules    4.6 Larval Fat Body    6.8 Larval Salivary Gland    4.4 Larval Trachea    3.65 Larval Carcass    6.375 Adult Head    5.7 Adult Eye    3.1 Adult Brain    5.1 Adult Thoracic-Abdominal Ganglion    4.3 Adult Crop    4.8 Adult Midgut no informative data Adult Hindgut    4.8 Adult Malpighian Tubules    5.2 Adult Fat Body    6.1 Adult Salivary Gland    9 Adult Heart    6.475 Adult VirginFemale Spermatheca    8.8 Adult InseminatedFemale Spermatheca    4.9 Adult Ovary    2.5 Adult Testis    2.1 Adult Male Accessory Gland    5.6 Adult Carcass no informative data Expression Level Scale  None   Low  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    5.95 Larval Midgut    7.9 Larval Hindgut    3.7 Larval Malpighian Tubules    4.6 Larval Fat Body    6.8 Larval Salivary Gland    4.4 Larval Trachea    3.65 Larval Carcass    6.375 Adult Head    5.7 Adult Eye    3.1 Adult Brain    5.1 Adult Thoracic-Abdominal Ganglion    4.3 Adult Crop    4.8 Adult Midgut no informative data Adult Hindgut    4.8 Adult Malpighian Tubules    5.2 Adult Fat Body    6.1 Adult Salivary Gland    9 Adult Heart    6.475 Adult VirginFemale Spermatheca    8.8 Adult InseminatedFemale Spermatheca    4.9 Adult Ovary    2.5 Adult Testis    2.1 Adult Male Accessory Gland    5.6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    5.95 Larval Midgut    7.9 Larval Hindgut    3.7 Larval Malpighian Tubules    4.6 Larval Fat Body    6.8 Larval Salivary Gland    4.4 Larval Trachea    3.65 Larval Carcass    6.375 Adult Head    5.7 Adult Eye    3.1 Adult Brain    5.1 Adult Thoracic-Abdominal Ganglion    4.3 Adult Crop    4.8 Adult Midgut no informative data Adult Hindgut    4.8 Adult Malpighian Tubules    5.2 Adult Fat Body    6.1 Adult Salivary Gland    9 Adult Heart    6.475 Adult VirginFemale Spermatheca    8.8 Adult InseminatedFemale Spermatheca    4.9 Adult Ovary    2.5 Adult Testis    2.1 Adult Male Accessory Gland    5.6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    5.95 Larval Midgut    7.9 Larval Hindgut    3.7 Larval Malpighian Tubules    4.6 Larval Fat Body    6.8 Larval Salivary Gland    4.4 Larval Trachea    3.65 Larval Carcass    6.375 Adult Head    5.7 Adult Eye    3.1 Adult Brain    5.1 Adult Thoracic-Abdominal Ganglion    4.3 Adult Crop    4.8 Adult Midgut no informative data Adult Hindgut    4.8 Adult Malpighian Tubules    5.2 Adult Fat Body    6.1 Adult Salivary Gland    9 Adult Heart    6.475 Adult VirginFemale Spermatheca    8.8 Adult InseminatedFemale Spermatheca    4.9 Adult Ovary    2.5 Adult Testis    2.1 Adult Male Accessory Gland    5.6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut no informative data Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    5.7   NA  Eye    3.1   NA  Brain    5.1   5.95  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    4.3   NA  Crop    4.8   7.9  Midgut    no informative data   3.7  Hindgut    4.8   4.6  Malpighian Tubules    5.2   6.8  Fat Body    6.1   4.4  Salivary Gland    9   NA  Heart    6.475   3.65  Trachea    NA   NA  VirginFemale Spermatheca    8.8   NA  InseminatedFemale Spermatheca    4.9   NA  Ovary    2.5   NA  Testis    2.1   NA  Male Accessory Gland    5.6   6.375  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003747 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG15779-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 Gr5aGD716 Other Phenotypes Allele feeding behavior defective Gr5aΔEP19 neurophysiology defective Gr5aΔEP5 Gr5aΔEP19 neurophysiology defective | adult stage Gr5aΔEP5 proboscis extension reflex defective Gr5aΔEP5 taste perception defective Gr5a01 Gr5aΔEP1 Gr5aΔEP3 Gr5aΔEP5 Gr5aΔEP7 Gr5aΔEP11 Gr5aΔEP12 Gr5aΔEP13 Gr5aΔEP14 Gr5aΔEP18 Gr5aΔEP19 taste perception defective | recessive Gr5aΔEP5 taste perception defective | semidominant Gr5a01 Phenotype manifest in Allele labellar taste bristle Gr5aΔEP19 large labellar taste bristle Gr5aΔEP19 Gr5aΔEP5
Classical Alleles ( 64 )
For All Classical Alleles Show
Allele of Gr5a Class Mutagen Stocks Known lesion Gr5aGS7438 1 Yes Gr5a01 natural population 0 Yes Gr5ahp01 natural population 0 Yes Gr5ahp02 natural population 0 Yes Gr5ahp03 natural population 0 Yes Gr5ahp04 natural population 0 Yes Gr5ahp05 natural population 0 Yes Gr5ahp06 natural population 0 Yes Gr5ahp07 natural population 0 Yes Gr5ahp08 natural population 0 Yes Gr5ahp09 natural population 0 Yes Gr5ahp10 natural population 0 Yes Gr5ahp11 natural population 0 Yes Gr5ahp12 natural population 0 Yes Gr5ahp13 natural population 0 Yes Gr5ahp14 natural population 0 Yes Gr5ahp15 natural population 0 Yes Gr5ahp16 natural population 0 Yes Gr5ahp17 natural population 0 Yes Gr5ahp18 natural population 0 Yes Gr5ahp19 natural population 0 Yes Gr5ahp20 natural population 0 Yes Gr5ahp21 natural population 0 Yes Gr5ahp22 natural population 0 Yes Gr5ahp23 natural population 0 Yes Gr5ahp24 natural population 0 Yes Gr5ahp25 natural population 0 Yes Gr5ahp26 natural population 0 Yes Gr5ahp27 natural population 0 Yes Gr5ahp28 natural population 0 Yes Gr5ahp29 natural population 0 Yes Gr5ahp30 natural population 0 Yes Gr5ahp31 natural population 0 Yes Gr5ahp32 natural population 0 Yes Gr5ahp33 natural population 0 Yes Gr5ahp34 natural population 0 Yes Gr5ahp35 natural population 0 Yes Gr5ahp36 natural population 0 Yes Gr5ahp37 natural population 0 Yes Gr5ahp38 natural population 0 Yes Gr5ahp39 natural population 0 Yes Gr5ahp40 natural population 0 Yes Gr5ahp41 natural population 0 Yes Gr5ahp42 natural population 0 Yes Gr5ahp43 natural population 0 Yes Gr5ahp44 natural population 0 Yes Gr5ahp45 natural population 0 Yes Gr5ahp46 natural population 0 Yes Gr5ahp47 natural population 0 Yes Gr5ahp48 natural population 0 Yes Gr5ahp49 natural population 0 Yes Gr5ahp50 natural population 0 Yes Gr5ahp51 natural population 0 Yes Gr5ahp52 natural population 0 Yes Gr5aΔEP11 Delta2-3 0 Yes Gr5aΔEP12 Delta2-3 0 Yes Gr5aΔEP13 Delta2-3 0 Yes Gr5aΔEP14 Delta2-3 0 Yes Gr5aΔEP18 Delta2-3 0 Yes Gr5aΔEP19 Delta2-3 0 Yes Gr5aΔEP1 Delta2-3 0 Yes Gr5aΔEP3 Delta2-3 0 Yes Gr5aΔEP5 Delta2-3 0 Yes Gr5aΔEP7 Delta2-3 0 Yes
Alleles Carried on Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Gr5a Class Mutagen Stocks Known lesion Gr5aGD716 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Gr5aJF01223 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Gr5aJF01224 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Gr5a+t10 in vitro construct - genomic fragment 0 Yes Gr5aKK112090 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Gr5aMtnA.PC in vitro construct - regulatory fusion 0 Yes Gr5aScer\UAS.cDa in vitro construct - regulatory fusion 0 Yes Gr5aSTOP in vitro construct - amino acid replacement 0 Yes
Aneuploid Aberrations
Disrupted in	Df(1)Exel6236 (Ryder, 2004.4.26) Df(1)TreΔEP1 (Ueno et al., 2001) Df(1)TreΔEP3 (Ueno et al., 2001) Df(1)TreΔEP5 (Ueno et al., 2001) Df(1)TreΔEP13 (Ueno et al., 2001) Df(1)TreΔEP18 (Ueno et al., 2001)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{KK112090} NA P{UAS-Gr5a.D} NA characterization construct P{T+G+} NA P{T+G-} NA P{T-G+} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}Tre1EP496 NA P{GSV1}EP-469.2EP-469.2 NA P{GSV1}Tre1GS1027 NA P{GSV1}Tre1GS1084 NA P{GSV2}Gr5aGS7438 NA P{Mae-UAS.6.11}B2009B2009 NA P{Mae-UAS.6.11}GG01179GG01179 NA miscellaneous insertions P{GT1}BG00218 NA
Gene Ontology: Function, Process & Cellular Component ( 9 unique terms )
Terms Based on Experimental Evidence ( 7 terms )
Molecular Function
CV term Evidence References
sweet taste receptor activity inferred from mutant phenotype (Dahanukar et al., 2007) taste receptor activity inferred from mutant phenotype (Dahanukar et al., 2001) inferred from mutant phenotype (assigned by UniProtKB) (Ueno et al., 2001)
Biological Process
CV term Evidence References
detection of chemical stimulus involved in sensory perception of taste inferred from direct assay (Chyb et al., 2003) inferred from mutant phenotype (Jiao et al., 2008) proboscis extension reflex inferred from mutant phenotype (Dahanukar et al., 2007) response to trehalose stimulus inferred from mutant phenotype (Ueno et al., 2006) sensory perception of sweet taste inferred from mutant phenotype (Ueno et al., 2006, Dahanukar et al., 2007) inferred from mutant phenotype (assigned by UniProtKB) (Ueno et al., 2001) sensory perception of taste inferred from direct assay (Usui-Aoki et al., 2005) inferred from mutant phenotype (assigned by UniProtKB) (Ueno et al., 2001)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
G-protein coupled receptor activity non-traceable author statement (Swiss-Prot Project Members, 2002.3.1) taste receptor activity inferred from sequence or structural similarity (assigned by UniProtKB) (Clyne et al., 2000) non-traceable author statement (assigned by UniProtKB) (Dunipace et al., 2001) traceable author statement (Matsunami and Amrein, 2003)
Biological Process
CV term Evidence References
sensory perception of taste inferred from sequence or structural similarity (assigned by UniProtKB) (Clyne et al., 2000) non-traceable author statement (assigned by UniProtKB) (Dunipace et al., 2001)
Cellular Component
CV term Evidence References
integral to membrane non-traceable author statement (Swiss-Prot Project Members, 2002.3.1) non-traceable author statement (assigned by UniProtKB) (Clyne et al., 2000, Dunipace et al., 2001, Ueno et al., 2001)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Gr5a allele Gene References unspecified pbl (Gregory et al., 2007)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 69345 DroID - A comprehensive database of gene and protein interactions. • FBgn0003747 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 44873
Orthologs
Genome-wide drosophilid orthologs	Dana\GF21367 Dere\GG18774 Dmoj\GI16250 Dsec\GM12425 Dsim\GD16742 Dvir\GJ16715 Dwil\GK19970 Dyak\GE16417
Curated drosophilid orthologs
Linkouts	OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0233943 FBgn0221967 FBgn0203896 FBgn0188330 FBgn0167362 FBgn0138999 FBgn0110982 FBgn0098369
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	31282 y1 v1; P{TRiP.JF01223}attP2 31283 y1 v1; P{TRiP.JF01224}attP2
Kyoto	201255 y1 w67c23 P{GSV2}Gr5aGS7438/Binsinscy
VDRC	v12347 w1118; P{GD716}v12347 v13730 w1118; P{GD716}v13730
Genomic Clones ( 2 )
	BACR27C07 BACR27J18 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 5 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	IP03620 IP03720 IP03920
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	107211 EK233053
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0003747 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 44873
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Tre CG15779 (Isono, 2001.9.22) Source for merge of: Tre Gr5a (Ueno et al., 2001)
Additional comments	The symbol used in FlyBase for this gene has been changed from "Tre" (Trehalose-sensitivity) to "Gr5a" (Gustatory receptor 5a) to match the format used for other gustatory receptor genes, and to avoid confusion with the neighbouring "Tre1" (Trapped in endoderm 1) gene. (FlyBase, 2009-) Although FBrf0128502 reported that Tre1, which maps extremely close to Gr5a, mediates the trehalose response, the balance of evidence suggests that Gr5a, rather than Tre1, encodes a trehalose receptor. (Dahanukar et al., 2001) The "CG15779"/"Gr5a" gene corresponds to the "Trehalose-sensitivity" complementation group as opposed to the "CG3171" gene, as was reported in FBrf0128502. (Isono, 2001.9.22) Expression of mRNAs in mutant flies, expression analysis in wild-type flies and amino acid polymorphism data suggest that the "Gr5a" and not "CG3171" corresponds to the "Tre" (Trehalose-sensitivity) locus. (Ueno et al., 2001) Evidence from FBrf0138267 (expression of mRNAs in mutant flies, expression analysis in wild-type flies and amino acid polymorphism data) suggests that the CG15779 gene prediction (Gr5a) corresponds to the "Trehalose-sensitivity" locus, mutation of which results in low sensitivity to trehalose. The "Trehalose-sensitivity" locus does not correspond to "Tre1" from FBrf0128502 which corresponds to the CG3171 gene prediction (which is adjacent to and divergently transcribed from CG15779). Mutation of Tre1 may also affect the sensitivity of flies to trehalose since mutants affecting Tre1 also show low sensitivity to trehalose which can be rescued by overexpression of Tre1 (FBrf0128502). (FlyBase, 1992-)
Other Comments
	Gr5a encodes a taste receptor required for response to the sugar trehalose, but not for response to sucrose, indicating a role for G protein-mediated signalling in the transduction of sweet taste. (Dahanukar et al., 2001) Encodes a gustatory sugar receptor involved in the response to trehalose. (Ueno et al., 2001) Genetic evidence suggests Gr5a is the structural gene for the trehalose receptor. Trehalose sensitivity decreases in females carrying half the normal dosage of Gr5a, but does not increase with an increase in Gr5a dosage. Changes in sensitivity of several aneuploid flies suggest there is an upper limit to the number of molecules that can be incorporated into the receptor membrane. (Tanimura et al., 1988)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078495 RefSeq (Proteins) • NP_511050 DDBJ / EMBL / GenBank • AAF46060 AB066610 AB066611 AB066612 AB066619 AB066620 AB066621 AB066622 AB066623 AB066624 AB066625 AB066626 AB066627 AB066628 AB066629 AB066630 AB066631 AB066632 AB066633 AB066634 AB066635 AB066636 AB066637 AB066638 AB066639 AB066640 AB066641 AB066642 AB066643 AB162449 AB162450 AB162451 AB162452 AB162453 AB162454 AB162455 AB162456 AB162457 AB162458 AB162459 AB162460 AB162461 AB162462 AB162463 AB162464 AB162465 AB162466 AB162467 AB162468 AB162469 AB162470 AB162471 AB162472 AB162473 AB162474 AB162475 AB162476 AB162477 AB162478 AB162479 AB162480 AB162481 AB162482 AB162483 AB162484 AB162485 AB162486 AB162487 AB162488 AB162489 AB162490 AB162491 AB162492 AB162493 AB162494 AB162495 AB162496 AB162497 AB162498 AB162499 AB162500 AB162501 AB162502 AB162503 AB162504 AB162505 AB162506 AB162507 AB162508 AB162509 AB162510 AB162511 AB162512 AB162513 AB162514 AB162515 AB162516 AB162517 AB162518 AB162519 AB162520 AB162521 AB162522 AB162523 AB162524 AB162525 AB162526 AB162527 AB162528 AB162529 AB162530 AB162531 AB162532 AB162533 AB162534 AB162535 AB162536 AB162537 AB162538 AB162539 AB162540 AB162541 AB162542 AB162543 AB162544 AB162545 AB162546 AB162547 AB162548 AB162549 AB162550 AB162551 AB162552 AB162553 AB162554 AB162555 AB162556 AB162557 AB162558 AB162559 AB162560 AB162561 AB162562 AB162563 AB162564 AB162565 AB162566 AB162567 AB162568 AB162569 AB162570 AB162571 AB162572 AB162573 AB162574 AB162575 AB162576 AB162577 AB162578 AB162579 AB162580 AB162581 AB162582 AB162583 AB162584 AB162585 AB162586 AB162587 AB162588 AB162589 AB162590 AB162591 AB162592 AB162593 AB162594 AB162595 AB162596 AB162597 AB162598 AB162599 AB162600 AB162601 AB162602 AB162603 AB162604 AB162605 AB162606 AB162607 AB162608 AB162609 AB162610 AB162611 AB162612 AX058703 BAB68243 BAB68244 BAB68245 BAB68246 BAB68247 BAB68248 BAB68249 BAB68250 BAB68251 BAB68252 BAB68253 BAB68254 BAB68255 BAB68256 BAB68257 BAB68258 BAB68259 BAB68260 BAB68261 BAB68262 BAB68263 BAB68264 BAB68265 BAB68266 BAB68267 BAD42667 BAD42668 BAD42669 BAD42670 BAD42671 BAD42672 BAD42673 BAD42674 BAD42675 BAD42676 BAD42677 BAD42678 BAD42679 BAD42680 BAD42681 BAD42682 BAD42683 BAD42684 BAD42685 BAD42686 BAD42687 BAD42688 BAD42689 BAD42690 BAD42691 BAD42692 BAD42693 BAD42694 BAD42695 BAD42696 BAD42697 BAD42698 BAD42699 BAD42700 BAD42701 BAD42702 BAD42703 BAD42704 BAD42705 BAD42706 BAD42707 BAD42708 BAD42709 BAD42710 BAD42711 BAD42712 BAD42713 BAD42714 BAD42715 BAD42716 BAD42717 BAD42718 BAD42719 BAD42720 BAD42721 BAD42722 BAD42723 BAD42724 BAD42725 BAD42726 BAD42727 BAD42728 BAD42729 BAD42730 BAD42731 BAD42732 BAD42733 BAD42734 BAD42735 BAD42736 BAD42737 BAD42738 BAD42739 BAD42740 BAD42741 BAD42742 BAD42743 BAD42744 BAD42745 BAD42746 BAD42747 BAD42748 BAD42749 BAD42750 BAD42751 BAD42752 BAD42753 BAD42754 BAD42755 BAD42756 BAD42757 BAD42758 BAD42759 BAD42760 BAD42761 BAD42762 BAD42763 BAD42764 BAD42765 BAD42766 BAD42767 BAD42768 BAD42769 BAD42770 BAD42771 BAD42772 BAD42773 BAD42774 BAD42775 BAD42776 BAD42777 BAD42778 BAD42779 BAD42780 BAD42781 BAD42782 BAD42783 BAD42784 BAD42785 BAD42786 BAD42787 BAD42788 BAD42789 BAD42790 BAD42791 BAD42792 BAD42793 BAD42794 BAD42795 BAD42796 BAD42797 BAD42798 BAD42799 BAD42800 BAD42801 BAD42802 BAD42803 BAD42804 BAD42805 BAD42806 BAD42807 BAD42808 BAD42809 BAD42810 BAD42811 BAD42812 BAD42813 BAD42814 BAD42815 BAD42816 BAD42817 BAD42818 BAD42819 BAD42820 BAD42821 BAD42822 BAD42823 BAD42824 BAD42825 BAD42826 BAD42827 BAD42828 BAD42829 BAD42830 CAC22536 Entrez Gene - A searchable database of RefSeq genes. • 44873 UniProtKB/Swiss-Prot • Q9W497 UniProtKB/TrEMBL • Q68AZ6 Q68AZ7 Q68AZ8 Q68AZ9 Q68B00 Q68B02 Q68B03 Q68B04 Q68B06
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Trehalose receptor (IPR009318)
Linkouts
	BioGRID - A database of protein and genetic interactions • 69345 DroID - A comprehensive database of gene and protein interactions. • FBgn0003747 DRSC - Results from RNAi screens. • FBgn0003747 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003747 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG15779-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0003747 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 44873 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /dbzhnsky/trehlos1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 44873 modMine - Data generated by the modENCODE project. • FBgn0003747 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0233943 FBgn0221967 FBgn0203896 FBgn0188330 FBgn0167362 FBgn0138999 FBgn0110982 FBgn0098369
Synonyms & Secondary IDs ( 17 )
Reported As
Symbol Synonym	CG15779 (Dahanukar et al., 2001, Marcus, 2003, Isono, 2001.9.22, Dunipace et al., 2001, Molnar et al., 2006, Grieder et al., 2007, Ni et al., 2008, Keleman et al., 2009.8.5) Dmel5a (Kent and Robertson, 2009) Gr5 (Marella et al., 2006) Gr5a (Amrein and Thorne, 2005, Wang et al., 2004, Stocker, 2004, Inomata et al., 2004, Thorne et al., 2004, Chyb et al., 2003, Kunwar et al., 2003, Giarratani and Vosshall, 2003, Dahanukar et al., 2004, Dahanukar et al., 2001, Matsunami and Amrein, 2003, Kim and Carlson, 2002, Robertson, 2001.11.11, Ueno et al., 2001, Dunipace et al., 2001, Morita et al., 2005, Ueno et al., 2006, Ueno and Kidokoro, 2007, de Bruyne and Warr, 2006, Scott, 2005, van der Goes van Naters and Carlson, 2006, Jiao et al., 2007, Fischler et al., 2007, Moon and Montell, 2008, Colomb and Stocker, 2007, Bredendiek et al., 2011, McBride et al., 2007, Hiroi et al., 2008, Dahanukar et al., 2007, Jiao et al., 2008, Gordon and Scott, 2009, Bharucha et al., 2008, Gardiner et al., 2009, Rollmann et al., 2006, Thorne and Amrein, 2008, Zhou et al., 2009, Chatterjee et al., 2010, Cameron et al., 2010, Ebbs and Amrein, 2007, Weiss et al., 2011, Weiss et al., 2011, Usui-Aoki et al., 2005) GR5A (Cameron et al., 2010) Gr5A1 (Scott and Axel, 2001.4.25, Scott et al., 2001) GrLU7 (Scott and Axel, 2001.4.25) GRLU.7   han (Scott, 2005) LU.7 (Clyne et al., 2000) tre (Matsunami and Amrein, 2003) Tre (Gregory et al., 2007, Grieder et al., 2007, Ramos et al., 2006, Molnar et al., 2006, Lindsley and Zimm, 1992, Rollmann et al., 2006, Cameron et al., 2010, Zhou et al., 2009)
Name Synonym	Gr5a (Scott, 2005) Gustatory receptor 5a (Marella et al., 2006, ) gustatory receptor 5a (Rollmann et al., 2006) Gustatory receptor LU.7 (Clyne et al., 2000) Trehalose sensitivity (Lindsley and Zimm, 1992) Trehalose-sensitivity
Secondary FlyBase IDs
	FBgn0029787 FBgn0041213
References ( 81 )
Generate a list of	All references relating to this gene ( 81 )
List References by type	Research paper  ( 44 ) Supplementary material  ( 5 ) Review  ( 9 ) Personal communication to FlyBase  ( 7 ) Abstract  ( 10 ) FlyBase analysis  ( 2 ) Book  ( 1 ) Protein sequence record  ( 1 ) Computer file  ( 1 ) Patent  ( 1 )
Recent research papers ( 5 )
	Bredendiek et al., 2011, Chem. Senses 36(1): 69--81 Go α is involved in sugar perception in Drosophila. [FBrf0212580] Park and Kwon, 2011, Mol. Cells 32(4): 375--381 A systematic analysis of Drosophila gustatory receptor gene expression in abdominal neurons which project to the central nervous system. [FBrf0216510] Weiss et al., 2011, Neuron 69(2): 258--272 The Molecular and Cellular Basis of Bitter Taste in Drosophila. [FBrf0212834] Cameron et al., 2010, Nature 465(7294): 91--95 The molecular basis for water taste in Drosophila. [FBrf0210723] Chatterjee et al., 2010, Curr. Biol. 20(4): 300--309 Regulation of Gustatory Physiology and Appetitive Behavior by the Drosophila Circadian Clock. [FBrf0210123] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...