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Gene Dmel\Treh

General Information
Symbol	Dmel\Treh	Species	D. melanogaster
Name	Trehalase	Annotation symbol	CG9364
Feature type	protein_coding_gene	FlyBase ID	FBgn0003748
Gene Model Status	Current	Stock availability	15 publicly available
Also Known As	TRE
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	57B16-57B19	Sequence location	2R:16,961,523..16,976,450 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Trehalase is referred to in FlyBase by the symbol Dmel\Treh (CG9364, FBgn0003748). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: trehalase activity. Based on sequence similarity, it is predicted to be involved in the biological process: trehalose metabolic process. 21 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; mesothoracic tergum. It has 7 annotated transcripts and 7 annotated polypeptides. Protein features are: Glycoside hydrolase, family 37; Glycoside hydrolase, family 37, conserved site; Six-hairpin glycosidase-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 18-24 hour embryonic stages, during early larval stages, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult midgut, adult hindgut, adult heart, larval/adult salivary gland, virgin spermatheca, adult male reproductive system, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult crop, larval midgut, adult Malpighian tubules, larval/adult fat body, larval trachea, adult female reproductive system, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1635692_s_at completely aligns to an exonic region common to each of the 6 FlyBase-annotated transcript isoforms of Treh. Gene sequence location is 2R:16961523..16976450.
User Contributed Data
	Beta version, feedback welcome
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	Treh: Trehalase Structural gene for trehalase [TRE (EC 3.2.1.28)], a hydrolase that splits the sugar trehalose into two glucose molecules. Polyacrylamide gel electrophoresis and isoelectric focusing indicates the presence of one molecular form of the enzyme in flight muscles, hemolymph, and abdomens of adult flies. No mutant alleles obtained.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 57B16-57B19   Limits computationally determined from genome sequence between P{EP}grauEP688&P{PZ}shg10469 and P{PZ}king-tubby02821&P{lacW}Xbp1k13803
Experimentally Determined Cytological Location
Cytogenetic map Notes References 57B-57C   (determined by in situ hybridisation)   (Louis et al., 1997) 57B-57C   (determined by in situ hybridisation)   (EDGP Project Members, 1994-)
Experimentally Determined Recombination Data
Location	2-92.9 +/- 1.6 (Burton and la Spada, 1986) 1- (Choudhary et al., 1992) 2-92.0 (Clark et al., 1995)
Left of (cM)	bw (Burton and la Spada, 1986)
Right of (cM)	vg (Burton and la Spada, 1986)
Notes	There is 16% recombination between Treh and bw. (Burton and la Spada, 1986)
Gene Model & Products
Please see the GBrowse view of Dmel\Treh for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Low-frequency RNA-Seq exon junction(s) not annotated. Annotated transcripts do not represent all supported alternative splices within 5' UTR. Gene model reviewed during 5.45
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Treh-RA FBtr0071537  NM_166421   2758   560 Treh-RB FBtr0071538  NM_166425   2662   515 Treh-RC FBtr0071539  NM_166423   2928   596 Treh-RD FBtr0071536  NM_080082   2992   560 Treh-RE FBtr0071535  NM_166422   3354   560 Treh-RF FBtr0071540  NM_166424   2822   596 Treh-RG FBtr0332423  NM_001274186   2991   560
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Treh-PA   FBpp0071466   63.6   560   4.83     NP_726023   AAM68192 Treh-PB   FBpp0071467   58.7   515   4.68     NP_726027   AAF46669 Treh-PC   FBpp0071468   67.7   596   4.61     NP_726025   AAF46668 Treh-PD   FBpp0071465   63.6   560   4.83     NP_524821   AAF46667 Treh-PE   FBpp0071464   63.6   560   4.83     NP_726024   AAM68193 Treh-PF   FBpp0071469   67.7   596   4.61     NP_726026   AAM68194 Treh-PG   FBpp0304696   63.6   560   4.83     NP_001261115   AGB93647
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Glycoside hydrolase, family 37, conserved site (IPR018232) Glycoside hydrolase, family 37 (IPR001661) Six-hairpin glycosidase-like (IPR008928)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA567771   AE013599 AAF46667   AE013599 AAF46668   AE013599 AAF46669   AE013599 AAM68192   AE013599 AAM68193   AE013599 AAM68194   AF083507   AF083508   AE013599 AGB93647   AI107563   AI107696   AI109533   AI135635   AI238692   AI239243   AI239247   AI294408   AI297750   AI297786   AI389927   AI403549   AI514015   AI533111   AI546273   AW941768   AY051466 AAK92890   BF493851   BF500452   BF501268   BF506669   BG633246   BG640317   BI166143   BI169211   BI171317   BI216358   BI230862   BI231730   BI241754   BI243327   BI351719   BI363420   BI481631   BI483955   BI486727   BI579468   BI592922   BI604262   BI608585   BI609519   BI627241   BI635803   BI637887   BP556410   BT099937   CA804737   CK662004   CL527963   CO177803   CO195620   CO299256   CO308098   CO321565   CO322552   CO329274   CO333113   CW848267   CZ471563   CZ471642   CZ471643   CZ471986   CZ473138   CZ476628   EC073634   EC074446   EC087386   EC089067   EC090185   EC235027   EC237487   EC237522   EC239828   EV577428   EV587730   EV595646   GH747878   GH748314   GH749344   GH749621   GH749848   GH750069   GH751006   GH751198   GH751472   GH751568   GH751776   GH754842   GH757175   GH758711   GH759228   GH759512   GH759644   GH759862   GH759942   GH759985   GH770844   GH771811   GH772410   GH772722   GH774831   GH776224   GH776360   GH778932   GH780837   GH781525   GH781833   GH781996   GH783070   GH783839   GH783971   GH784849   GH785757   GH788032   GH788250   GH789028   GH789805   GH790571   GH790592   GH791056   GH791619   GH791699   GH792187   GH795657   GH796773   GH796892   GH797096   GH797256   GH797450   GH797879   GH799061   GH802169   GH803408   GH803551   GH804274   GH804690   GH809613   GH810345   GH810869   GH812243   GH813064   GH817283   GH818834   GH819654   GH819723   GH819857   GH820193   GH820927   GH822017   GH822101   GH822507   GH823188   GH823995   GH825110   GH825718   GH826485   GH826909   GH827222   GH827818   GH829706   GH829963   GH830612   GH832324   GH832824   GH834150   GH835343   GH835705   GH836343   GH837162   GH838484   GH839776   GH840327   GH840533   GH840666   GH846522   GH847110   GH849085   GH849875   GH850238   GH851134   GH851836   GH852594   GH853138   GH853996   GH854163   GH855272   GH855511   GH855651   GH857238   GH857330   GH857611   GH857696   GH858049   GH858490   GH859136   GH860073   GH860919   GH861626   GH862908   GH864295   GH865741   GH866728   GH866870   GH866904   GH868029   GH868073   GH868285   GH868611   GH868710   GH868854   GH869041   GH869230   GH870230   GH870653   GH873272   GH874261   GH874741   GH875116   GH875413   GH875678   GH876000   GH877974   GH878449   GH880285   GH880482   GH884679   GH885479   GH885741   GH886834   GH887611   GH887673   GH887961   GH888729   GH889015   GH889021   GH889062   GH889098   GH889241   GH890656   GH890986   GH892773   GH893404   GH893749   GH893762   GH895248   GH896256   GH896339   GH896398   GH897894   GH898152   GH901779   GH902492   GH902555   GH903654   GH904014   GH905588   GH906088   GH906723   GH907378   GH909389   GH909441   GH909953   GH910078   GH910184   GH912817   GH913635   GH914270   GH914739   GH915113   GH915642   GH917562   GH918179   GH919411   GH919659   GH919711   GH920541   GH921483   GH921671   GH921977   GH922329   GH922404   GH922479   GH923624   GH924302   GH924954   GH925256   GH925512   GH926084   GH926463   GH927156   GH928214   GH929324   GH931559   GH932051   GH932485   GH932571   GH932796   GH933178   GH933882   GH935377   GH935432   GH936355   GH936787   GH937135   GH937484   GH938148   GH938180   GH938461   GH938840   GH939362   GH939377   GH939401   GH940203   GH940436   GH940544   GH940731   GH940739   GH946362   GH964902   GH974817   GH980850   Z50689
UniProtKB/Swiss-Prot	Q9W2M2
UniProtKB/TrEMBL	A4UZR3
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism   • cytoplasm | basal (Fisher et al., 2012) Comment:apically cleared embryonic stage 9 -- 10   dorsal ectoderm   (Fisher et al., 2012) embryonic stage 11 -- 12   dorsal epidermis primordium   (Fisher et al., 2012) posterior midgut primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   crystal cell   (Fisher et al., 2012) dorsal pharyngeal muscle   (Fisher et al., 2012) embryonic dorsal epidermis   (Fisher et al., 2012) embryonic/larval corpus allatum   (Fisher et al., 2012) embryonic/larval corpus cardiacum   (Fisher et al., 2012) embryonic/larval dorsal trunk   (Fisher et al., 2012) embryonic/larval lymph gland   (Fisher et al., 2012) embryonic/larval muscle system   (Fisher et al., 2012) embryonic/larval somatic muscle   (Fisher et al., 2012) germline cell   (Fisher et al., 2012) lateral cord surface glial cell   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult midgut, adult hindgut, adult heart, larval/adult salivary gland, virgin spermatheca, adult male reproductive system, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult crop, larval midgut, adult Malpighian tubules, larval/adult fat body, larval trachea, adult female reproductive system, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    571.3 Larval Midgut    171.3 Larval Hindgut    99.5 Larval Malpighian Tubules    73.4 Larval Fat Body    257.8 Larval Salivary Gland    664 Larval Trachea    143.425 Larval Carcass    233.45 Adult Head    878.2 Adult Eye    801.6 Adult Brain    1356.8 Adult Thoracic-Abdominal Ganglion    1714.3 Adult Crop    398.7 Adult Midgut    529.1 Adult Hindgut    862.3 Adult Malpighian Tubules    189.6 Adult Fat Body    336.6 Adult Salivary Gland    1325.2 Adult Heart    665.825 Adult VirginFemale Spermatheca    507.8 Adult InseminatedFemale Spermatheca    386 Adult Ovary    348.3 Adult Testis    534.5 Adult Male Accessory Gland    692.5 Adult Carcass    611.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (571.3) Larval Midgut    171.3 Larval Hindgut    99.5 Larval Malpighian Tubules    73.4 Larval Fat Body    257.8 Larval Salivary Gland  (664) Larval Trachea    143.425 Larval Carcass    233.45 Adult Head  (878.2) Adult Eye  (801.6) Adult Brain  (1356.8) Adult Thoracic-Abdominal Ganglion  (1714.3) Adult Crop    398.7 Adult Midgut  529.1 Adult Hindgut  (862.3) Adult Malpighian Tubules    189.6 Adult Fat Body    336.6 Adult Salivary Gland  (1325.2) Adult Heart  (665.825) Adult VirginFemale Spermatheca  507.8 Adult InseminatedFemale Spermatheca    386 Adult Ovary    348.3 Adult Testis  534.5 Adult Male Accessory Gland  (692.5) Adult Carcass  (611.7) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    571.3 Larval Midgut    171.3 Larval Hindgut    99.5 Larval Malpighian Tubules    73.4 Larval Fat Body    257.8 Larval Salivary Gland    664 Larval Trachea    143.425 Larval Carcass    233.45 Adult Head    878.2 Adult Eye    801.6 Adult Brain  (1356.8) Adult Thoracic-Abdominal Ganglion  (1714.3) Adult Crop    398.7 Adult Midgut    529.1 Adult Hindgut    862.3 Adult Malpighian Tubules    189.6 Adult Fat Body    336.6 Adult Salivary Gland  (1325.2) Adult Heart    665.825 Adult VirginFemale Spermatheca    507.8 Adult InseminatedFemale Spermatheca    386 Adult Ovary    348.3 Adult Testis    534.5 Adult Male Accessory Gland    692.5 Adult Carcass    611.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    571.3 Larval Midgut    171.3 Larval Hindgut    99.5 Larval Malpighian Tubules    73.4 Larval Fat Body    257.8 Larval Salivary Gland    664 Larval Trachea    143.425 Larval Carcass    233.45 Adult Head    878.2 Adult Eye    801.6 Adult Brain    1356.8 Adult Thoracic-Abdominal Ganglion    1714.3 Adult Crop    398.7 Adult Midgut    529.1 Adult Hindgut    862.3 Adult Malpighian Tubules    189.6 Adult Fat Body    336.6 Adult Salivary Gland    1325.2 Adult Heart    665.825 Adult VirginFemale Spermatheca    507.8 Adult InseminatedFemale Spermatheca    386 Adult Ovary    348.3 Adult Testis    534.5 Adult Male Accessory Gland    692.5 Adult Carcass    611.7 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    571.3 Larval Midgut    171.3 Larval Hindgut    99.5 Larval Malpighian Tubules    73.4 Larval Fat Body    257.8 Larval Salivary Gland    664 Larval Trachea    143.425 Larval Carcass    233.45 Adult Head    878.2 Adult Eye    801.6 Adult Brain    1356.8 Adult Thoracic-Abdominal Ganglion    1714.3 Adult Crop    398.7 Adult Midgut    529.1 Adult Hindgut    862.3 Adult Malpighian Tubules    189.6 Adult Fat Body    336.6 Adult Salivary Gland    1325.2 Adult Heart    665.825 Adult VirginFemale Spermatheca    507.8 Adult InseminatedFemale Spermatheca    386 Adult Ovary    348.3 Adult Testis    534.5 Adult Male Accessory Gland    692.5 Adult Carcass    611.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  571.3 Larval Midgut    171.3 Larval Hindgut    99.5 Larval Malpighian Tubules    73.4 Larval Fat Body    257.8 Larval Salivary Gland  664 Larval Trachea    143.425 Larval Carcass    233.45 Adult Head  (878.2) Adult Eye  801.6 Adult Brain  (1356.8) Adult Thoracic-Abdominal Ganglion  (1714.3) Adult Crop    398.7 Adult Midgut  529.1 Adult Hindgut  (862.3) Adult Malpighian Tubules    189.6 Adult Fat Body    336.6 Adult Salivary Gland  (1325.2) Adult Heart  665.825 Adult VirginFemale Spermatheca  507.8 Adult InseminatedFemale Spermatheca    386 Adult Ovary    348.3 Adult Testis  534.5 Adult Male Accessory Gland  692.5 Adult Carcass  611.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    571.3 Larval Midgut    171.3 Larval Hindgut    99.5 Larval Malpighian Tubules    73.4 Larval Fat Body    257.8 Larval Salivary Gland    664 Larval Trachea    143.425 Larval Carcass    233.45 Adult Head    878.2 Adult Eye    801.6 Adult Brain  1356.8 Adult Thoracic-Abdominal Ganglion  1714.3 Adult Crop    398.7 Adult Midgut    529.1 Adult Hindgut    862.3 Adult Malpighian Tubules    189.6 Adult Fat Body    336.6 Adult Salivary Gland  1325.2 Adult Heart    665.825 Adult VirginFemale Spermatheca    507.8 Adult InseminatedFemale Spermatheca    386 Adult Ovary    348.3 Adult Testis    534.5 Adult Male Accessory Gland    692.5 Adult Carcass    611.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    571.3 Larval Midgut    171.3 Larval Hindgut    99.5 Larval Malpighian Tubules    73.4 Larval Fat Body    257.8 Larval Salivary Gland    664 Larval Trachea    143.425 Larval Carcass    233.45 Adult Head    878.2 Adult Eye    801.6 Adult Brain    1356.8 Adult Thoracic-Abdominal Ganglion    1714.3 Adult Crop    398.7 Adult Midgut    529.1 Adult Hindgut    862.3 Adult Malpighian Tubules    189.6 Adult Fat Body    336.6 Adult Salivary Gland    1325.2 Adult Heart    665.825 Adult VirginFemale Spermatheca    507.8 Adult InseminatedFemale Spermatheca    386 Adult Ovary    348.3 Adult Testis    534.5 Adult Male Accessory Gland    692.5 Adult Carcass    611.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    878.2   NA  Eye    801.6   NA  Brain    1356.8   571.3  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    1714.3   NA  Crop    398.7   171.3  Midgut    529.1   99.5  Hindgut    862.3   73.4  Malpighian Tubules    189.6   257.8  Fat Body    336.6   664  Salivary Gland    1325.2   NA  Heart    665.825   143.425  Trachea    NA   NA  VirginFemale Spermatheca    507.8   NA  InseminatedFemale Spermatheca    386   NA  Ovary    348.3   NA  Testis    534.5   NA  Male Accessory Gland    692.5   233.45  Carcass    611.7 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    34 central nervous system, larvae L3    32 central nervous system, pupae P8    64 head, virgin 1-day female    133 head, virgin 4-day female    144 head, virgin 20-day female    216 head, mated 1-day female    137 head, mated 4-day female    182 head, mated 20-day female    167 head, mated 1-day male    196 head, mated 4-day male    217 head, mated 20-day male    266 salivary gland, larvae L3 wandering    9 salivary gland, white prepupae    398 digestive system, larvae L3 wandering    22 digestive system, 1-day adult    108 digestive system, 4-day adult    90 digestive system, 20-day adult    131 fat body, larvae L3 wandering    27 fat body, white prepupae    21 fat body, pupae P8    61 carcass, larvae L3 wandering    62 carcass, 1-day adult    103 carcass, 4-day adult    100 carcass, 20-day adult    101 ovary, virgin 4-day female    45 ovary, mated 4-day female    44 testis, mated 4-day male    57 accessory gland, mated 4-day male    68 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (34) central nervous system, larvae L3  (32) central nervous system, pupae P8  (64) head, virgin 1-day female  (133) head, virgin 4-day female  (144) head, virgin 20-day female  (216) head, mated 1-day female  (137) head, mated 4-day female  (182) head, mated 20-day female  (167) head, mated 1-day male  (196) head, mated 4-day male  (217) head, mated 20-day male  (266) salivary gland, larvae L3 wandering    9 salivary gland, white prepupae  (398) digestive system, larvae L3 wandering    22 digestive system, 1-day adult  (108) digestive system, 4-day adult  (90) digestive system, 20-day adult  (131) fat body, larvae L3 wandering  (27) fat body, white prepupae    21 fat body, pupae P8  (61) carcass, larvae L3 wandering  (62) carcass, 1-day adult  (103) carcass, 4-day adult  (100) carcass, 20-day adult  (101) ovary, virgin 4-day female  (45) ovary, mated 4-day female  (44) testis, mated 4-day male  (57) accessory gland, mated 4-day male  (68) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    34 central nervous system, larvae L3    32 central nervous system, pupae P8    64 head, virgin 1-day female  (133) head, virgin 4-day female  (144) head, virgin 20-day female  (216) head, mated 1-day female  (137) head, mated 4-day female  (182) head, mated 20-day female  (167) head, mated 1-day male  (196) head, mated 4-day male  (217) head, mated 20-day male  (266) salivary gland, larvae L3 wandering    9 salivary gland, white prepupae  (398) digestive system, larvae L3 wandering    22 digestive system, 1-day adult  (108) digestive system, 4-day adult    90 digestive system, 20-day adult  (131) fat body, larvae L3 wandering    27 fat body, white prepupae    21 fat body, pupae P8    61 carcass, larvae L3 wandering    62 carcass, 1-day adult  103 carcass, 4-day adult    100 carcass, 20-day adult  101 ovary, virgin 4-day female    45 ovary, mated 4-day female    44 testis, mated 4-day male    57 accessory gland, mated 4-day male    68 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    34 central nervous system, larvae L3    32 central nervous system, pupae P8    64 head, virgin 1-day female    133 head, virgin 4-day female    144 head, virgin 20-day female    216 head, mated 1-day female    137 head, mated 4-day female    182 head, mated 20-day female    167 head, mated 1-day male    196 head, mated 4-day male    217 head, mated 20-day male    266 salivary gland, larvae L3 wandering    9 salivary gland, white prepupae    398 digestive system, larvae L3 wandering    22 digestive system, 1-day adult    108 digestive system, 4-day adult    90 digestive system, 20-day adult    131 fat body, larvae L3 wandering    27 fat body, white prepupae    21 fat body, pupae P8    61 carcass, larvae L3 wandering    62 carcass, 1-day adult    103 carcass, 4-day adult    100 carcass, 20-day adult    101 ovary, virgin 4-day female    45 ovary, mated 4-day female    44 testis, mated 4-day male    57 accessory gland, mated 4-day male    68 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    34 central nervous system, larvae L3    32 central nervous system, pupae P8    64 head, virgin 1-day female    133 head, virgin 4-day female    144 head, virgin 20-day female    216 head, mated 1-day female    137 head, mated 4-day female    182 head, mated 20-day female    167 head, mated 1-day male    196 head, mated 4-day male    217 head, mated 20-day male    266 salivary gland, larvae L3 wandering    9 salivary gland, white prepupae    398 digestive system, larvae L3 wandering    22 digestive system, 1-day adult    108 digestive system, 4-day adult    90 digestive system, 20-day adult    131 fat body, larvae L3 wandering    27 fat body, white prepupae    21 fat body, pupae P8    61 carcass, larvae L3 wandering    62 carcass, 1-day adult    103 carcass, 4-day adult    100 carcass, 20-day adult    101 ovary, virgin 4-day female    45 ovary, mated 4-day female    44 testis, mated 4-day male    57 accessory gland, mated 4-day male    68 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (34) central nervous system, larvae L3  32 central nervous system, pupae P8  (64) head, virgin 1-day female  (133) head, virgin 4-day female  (144) head, virgin 20-day female  (216) head, mated 1-day female  (137) head, mated 4-day female  (182) head, mated 20-day female  (167) head, mated 1-day male  (196) head, mated 4-day male  (217) head, mated 20-day male  (266) salivary gland, larvae L3 wandering    9 salivary gland, white prepupae  (398) digestive system, larvae L3 wandering    22 digestive system, 1-day adult  (108) digestive system, 4-day adult  (90) digestive system, 20-day adult  (131) fat body, larvae L3 wandering  27 fat body, white prepupae    21 fat body, pupae P8  (61) carcass, larvae L3 wandering  (62) carcass, 1-day adult  (103) carcass, 4-day adult  (100) carcass, 20-day adult  (101) ovary, virgin 4-day female  (45) ovary, mated 4-day female  (44) testis, mated 4-day male  (57) accessory gland, mated 4-day male  (68) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    34 central nervous system, larvae L3    32 central nervous system, pupae P8    64 head, virgin 1-day female  133 head, virgin 4-day female  (144) head, virgin 20-day female  (216) head, mated 1-day female  137 head, mated 4-day female  (182) head, mated 20-day female  (167) head, mated 1-day male  (196) head, mated 4-day male  (217) head, mated 20-day male  (266) salivary gland, larvae L3 wandering    9 salivary gland, white prepupae  (398) digestive system, larvae L3 wandering    22 digestive system, 1-day adult  108 digestive system, 4-day adult    90 digestive system, 20-day adult  131 fat body, larvae L3 wandering    27 fat body, white prepupae    21 fat body, pupae P8    61 carcass, larvae L3 wandering    62 carcass, 1-day adult  103 carcass, 4-day adult    100 carcass, 20-day adult  101 ovary, virgin 4-day female    45 ovary, mated 4-day female    44 testis, mated 4-day male    57 accessory gland, mated 4-day male    68 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    34 central nervous system, larvae L3    32 central nervous system, pupae P8    64 head, virgin 1-day female    133 head, virgin 4-day female    144 head, virgin 20-day female    216 head, mated 1-day female    137 head, mated 4-day female    182 head, mated 20-day female    167 head, mated 1-day male    196 head, mated 4-day male    217 head, mated 20-day male    266 salivary gland, larvae L3 wandering    9 salivary gland, white prepupae    398 digestive system, larvae L3 wandering    22 digestive system, 1-day adult    108 digestive system, 4-day adult    90 digestive system, 20-day adult    131 fat body, larvae L3 wandering    27 fat body, white prepupae    21 fat body, pupae P8    61 carcass, larvae L3 wandering    62 carcass, 1-day adult    103 carcass, 4-day adult    100 carcass, 20-day adult    101 ovary, virgin 4-day female    45 ovary, mated 4-day female    44 testis, mated 4-day male    57 accessory gland, mated 4-day male    68 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 18-24 hour embryonic stages, during early larval stages, at stages throughout the pupal period, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    24 embryo 02-04hr    6 embryo 04-06hr    2 embryo 06-08hr    3 embryo 08-10hr    5 embryo 10-12hr    16 embryo 12-14hr    17 embryo 14-16hr    15 embryo 16-18hr    14 embryo 18-20hr    62 embryo 20-22hr    76 embryo 22-24hr    81 larva L1    61 larva L2    88 larva L3 12hr old    52 larva L3 puffstage 1-2    37 larva L3 puffstage 3-6    35 larva L3 puffstage 7-9    39 white prepupae new    59 white prepupae 12hr    104 white prepupae 24hr    36 pupae 2d postWPP    51 pupae 3d postWPP    78 pupae 4d postWPP    74 adult male 01day    90 adult male 05day    88 adult male 30day    70 adult female 01day    64 adult female 05day    60 adult female 30day    62 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    24 embryo 02-04hr    6 embryo 04-06hr    2 embryo 06-08hr    3 embryo 08-10hr    5 embryo 10-12hr    16 embryo 12-14hr    17 embryo 14-16hr    15 embryo 16-18hr    14 embryo 18-20hr  (62) embryo 20-22hr  (76) embryo 22-24hr  (81) larva L1  (61) larva L2  (88) larva L3 12hr old  (52) larva L3 puffstage 1-2  (37) larva L3 puffstage 3-6  (35) larva L3 puffstage 7-9  (39) white prepupae new  (59) white prepupae 12hr  (104) white prepupae 24hr  (36) pupae 2d postWPP  (51) pupae 3d postWPP  (78) pupae 4d postWPP  (74) adult male 01day  (90) adult male 05day  (88) adult male 30day  (70) adult female 01day  (64) adult female 05day  (60) adult female 30day  (62) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    24 embryo 02-04hr    6 embryo 04-06hr    2 embryo 06-08hr    3 embryo 08-10hr    5 embryo 10-12hr    16 embryo 12-14hr    17 embryo 14-16hr    15 embryo 16-18hr    14 embryo 18-20hr    62 embryo 20-22hr    76 embryo 22-24hr    81 larva L1    61 larva L2    88 larva L3 12hr old    52 larva L3 puffstage 1-2    37 larva L3 puffstage 3-6    35 larva L3 puffstage 7-9    39 white prepupae new    59 white prepupae 12hr  104 white prepupae 24hr    36 pupae 2d postWPP    51 pupae 3d postWPP    78 pupae 4d postWPP    74 adult male 01day    90 adult male 05day    88 adult male 30day    70 adult female 01day    64 adult female 05day    60 adult female 30day    62 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    24 embryo 02-04hr    6 embryo 04-06hr    2 embryo 06-08hr    3 embryo 08-10hr    5 embryo 10-12hr    16 embryo 12-14hr    17 embryo 14-16hr    15 embryo 16-18hr    14 embryo 18-20hr    62 embryo 20-22hr    76 embryo 22-24hr    81 larva L1    61 larva L2    88 larva L3 12hr old    52 larva L3 puffstage 1-2    37 larva L3 puffstage 3-6    35 larva L3 puffstage 7-9    39 white prepupae new    59 white prepupae 12hr    104 white prepupae 24hr    36 pupae 2d postWPP    51 pupae 3d postWPP    78 pupae 4d postWPP    74 adult male 01day    90 adult male 05day    88 adult male 30day    70 adult female 01day    64 adult female 05day    60 adult female 30day    62 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    24 embryo 02-04hr    6 embryo 04-06hr    2 embryo 06-08hr    3 embryo 08-10hr    5 embryo 10-12hr    16 embryo 12-14hr    17 embryo 14-16hr    15 embryo 16-18hr    14 embryo 18-20hr    62 embryo 20-22hr    76 embryo 22-24hr    81 larva L1    61 larva L2    88 larva L3 12hr old    52 larva L3 puffstage 1-2    37 larva L3 puffstage 3-6    35 larva L3 puffstage 7-9    39 white prepupae new    59 white prepupae 12hr    104 white prepupae 24hr    36 pupae 2d postWPP    51 pupae 3d postWPP    78 pupae 4d postWPP    74 adult male 01day    90 adult male 05day    88 adult male 30day    70 adult female 01day    64 adult female 05day    60 adult female 30day    62 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    24 embryo 02-04hr    6 embryo 04-06hr    2 embryo 06-08hr    3 embryo 08-10hr    5 embryo 10-12hr    16 embryo 12-14hr    17 embryo 14-16hr    15 embryo 16-18hr    14 embryo 18-20hr  (62) embryo 20-22hr  (76) embryo 22-24hr  (81) larva L1  (61) larva L2  (88) larva L3 12hr old  (52) larva L3 puffstage 1-2  (37) larva L3 puffstage 3-6  (35) larva L3 puffstage 7-9  (39) white prepupae new  (59) white prepupae 12hr  (104) white prepupae 24hr  (36) pupae 2d postWPP  (51) pupae 3d postWPP  (78) pupae 4d postWPP  (74) adult male 01day  (90) adult male 05day  (88) adult male 30day  (70) adult female 01day  (64) adult female 05day  (60) adult female 30day  (62) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    24 embryo 02-04hr    6 embryo 04-06hr    2 embryo 06-08hr    3 embryo 08-10hr    5 embryo 10-12hr    16 embryo 12-14hr    17 embryo 14-16hr    15 embryo 16-18hr    14 embryo 18-20hr    62 embryo 20-22hr    76 embryo 22-24hr    81 larva L1    61 larva L2    88 larva L3 12hr old    52 larva L3 puffstage 1-2    37 larva L3 puffstage 3-6    35 larva L3 puffstage 7-9    39 white prepupae new    59 white prepupae 12hr  104 white prepupae 24hr    36 pupae 2d postWPP    51 pupae 3d postWPP    78 pupae 4d postWPP    74 adult male 01day    90 adult male 05day    88 adult male 30day    70 adult female 01day    64 adult female 05day    60 adult female 30day    62 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    24 embryo 02-04hr    6 embryo 04-06hr    2 embryo 06-08hr    3 embryo 08-10hr    5 embryo 10-12hr    16 embryo 12-14hr    17 embryo 14-16hr    15 embryo 16-18hr    14 embryo 18-20hr    62 embryo 20-22hr    76 embryo 22-24hr    81 larva L1    61 larva L2    88 larva L3 12hr old    52 larva L3 puffstage 1-2    37 larva L3 puffstage 3-6    35 larva L3 puffstage 7-9    39 white prepupae new    59 white prepupae 12hr    104 white prepupae 24hr    36 pupae 2d postWPP    51 pupae 3d postWPP    78 pupae 4d postWPP    74 adult male 01day    90 adult male 05day    88 adult male 30day    70 adult female 01day    64 adult female 05day    60 adult female 30day    62 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    33 Schneider line 2 Sg4    5 embryonic 1182-4H    10 embryonic GM2    18 embryonic Kc167    19 embryonic S1    28 embryonic S3    23 leg disc CME L1    13 wing disc CME-W2    16 wing disc ML-DmD8    30 wing disc ML-DmD9    12 wing disc ML-DmD16-c3    12 wing disc ML-DmD21    7 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    4 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    7 mixed discs ML-DmD4-c1    19 CNS ML-DmBG1-c1    95 CNS ML-DmBG2-c2    9 tumorous blood cells mbn2    32 ovary fGS/OSS    36 ovary OSC    19 ovary OSS    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (33) Schneider line 2 Sg4    5 embryonic 1182-4H    10 embryonic GM2    18 embryonic Kc167    19 embryonic S1  (28) embryonic S3    23 leg disc CME L1    13 wing disc CME-W2    16 wing disc ML-DmD8  (30) wing disc ML-DmD9    12 wing disc ML-DmD16-c3    12 wing disc ML-DmD21    7 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    4 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    7 mixed discs ML-DmD4-c1    19 CNS ML-DmBG1-c1  (95) CNS ML-DmBG2-c2    9 tumorous blood cells mbn2  (32) ovary fGS/OSS  (36) ovary OSC    19 ovary OSS    11 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    33 Schneider line 2 Sg4    5 embryonic 1182-4H    10 embryonic GM2    18 embryonic Kc167    19 embryonic S1    28 embryonic S3    23 leg disc CME L1    13 wing disc CME-W2    16 wing disc ML-DmD8    30 wing disc ML-DmD9    12 wing disc ML-DmD16-c3    12 wing disc ML-DmD21    7 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    4 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    7 mixed discs ML-DmD4-c1    19 CNS ML-DmBG1-c1    95 CNS ML-DmBG2-c2    9 tumorous blood cells mbn2    32 ovary fGS/OSS    36 ovary OSC    19 ovary OSS    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    33 Schneider line 2 Sg4    5 embryonic 1182-4H    10 embryonic GM2    18 embryonic Kc167    19 embryonic S1    28 embryonic S3    23 leg disc CME L1    13 wing disc CME-W2    16 wing disc ML-DmD8    30 wing disc ML-DmD9    12 wing disc ML-DmD16-c3    12 wing disc ML-DmD21    7 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    4 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    7 mixed discs ML-DmD4-c1    19 CNS ML-DmBG1-c1    95 CNS ML-DmBG2-c2    9 tumorous blood cells mbn2    32 ovary fGS/OSS    36 ovary OSC    19 ovary OSS    11 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    33 Schneider line 2 Sg4    5 embryonic 1182-4H    10 embryonic GM2    18 embryonic Kc167    19 embryonic S1    28 embryonic S3    23 leg disc CME L1    13 wing disc CME-W2    16 wing disc ML-DmD8    30 wing disc ML-DmD9    12 wing disc ML-DmD16-c3    12 wing disc ML-DmD21    7 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    4 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    7 mixed discs ML-DmD4-c1    19 CNS ML-DmBG1-c1    95 CNS ML-DmBG2-c2    9 tumorous blood cells mbn2    32 ovary fGS/OSS    36 ovary OSC    19 ovary OSS    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (33) Schneider line 2 Sg4    5 embryonic 1182-4H    10 embryonic GM2    18 embryonic Kc167    19 embryonic S1  28 embryonic S3    23 leg disc CME L1    13 wing disc CME-W2    16 wing disc ML-DmD8  30 wing disc ML-DmD9    12 wing disc ML-DmD16-c3    12 wing disc ML-DmD21    7 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    4 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    7 mixed discs ML-DmD4-c1    19 CNS ML-DmBG1-c1  (95) CNS ML-DmBG2-c2    9 tumorous blood cells mbn2  32 ovary fGS/OSS  (36) ovary OSC    19 ovary OSS    11 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    33 Schneider line 2 Sg4    5 embryonic 1182-4H    10 embryonic GM2    18 embryonic Kc167    19 embryonic S1    28 embryonic S3    23 leg disc CME L1    13 wing disc CME-W2    16 wing disc ML-DmD8    30 wing disc ML-DmD9    12 wing disc ML-DmD16-c3    12 wing disc ML-DmD21    7 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    4 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    7 mixed discs ML-DmD4-c1    19 CNS ML-DmBG1-c1    95 CNS ML-DmBG2-c2    9 tumorous blood cells mbn2    32 ovary fGS/OSS    36 ovary OSC    19 ovary OSS    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    33 Schneider line 2 Sg4    5 embryonic 1182-4H    10 embryonic GM2    18 embryonic Kc167    19 embryonic S1    28 embryonic S3    23 leg disc CME L1    13 wing disc CME-W2    16 wing disc ML-DmD8    30 wing disc ML-DmD9    12 wing disc ML-DmD16-c3    12 wing disc ML-DmD21    7 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    4 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    7 mixed discs ML-DmD4-c1    19 CNS ML-DmBG1-c1    95 CNS ML-DmBG2-c2    9 tumorous blood cells mbn2    32 ovary fGS/OSS    36 ovary OSC    19 ovary OSS    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    65 cold shock, 4-day adult    51 heat shock, 4-day adult    39 Cadmium 50 mM 6 hrs, larvae L3    26 Cadmium 50 mM 12 hrs, larvae L3    27 Cadmium 50 mM 48 hrs, 4-day adult    39 Cadmium 100 mM 48 hrs, 4-day adult    55 Copper 0.5 mM 12 hrs, larvae L3    14 Copper 15 mM 48 hrs, 4-day adult    50 Zinc 5 mM 12 hrs, larvae L3    24 Zinc 4.5 mM 48 hrs, 4-day adult    71 Ethanol 2.5% 3 hrs, larvae L3    54 Ethanol 5% 3 hrs, larvae L3    26 Ethanol 10% 3 hrs, larvae L3    24 Caffeine 1.5 mg/ml 4 hrs, larvae L3    43 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    66 Caffeine 25 mg/ml 48 hrs, 4-day adult    46 Paraquat 5 mM 48 hrs, 4-day adult    74 Paraquat 10 mM 48 hrs, 4-day adult    89 Rotenone 2 μg 12 hrs, larvae L3    41 Rotenone 8 μg 12 hrs, larvae L3    42 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (65) cold shock, 4-day adult  (51) heat shock, 4-day adult  (39) Cadmium 50 mM 6 hrs, larvae L3  26 Cadmium 50 mM 12 hrs, larvae L3  (27) Cadmium 50 mM 48 hrs, 4-day adult  (39) Cadmium 100 mM 48 hrs, 4-day adult  (55) Copper 0.5 mM 12 hrs, larvae L3    14 Copper 15 mM 48 hrs, 4-day adult  (50) Zinc 5 mM 12 hrs, larvae L3    24 Zinc 4.5 mM 48 hrs, 4-day adult  (71) Ethanol 2.5% 3 hrs, larvae L3  (54) Ethanol 5% 3 hrs, larvae L3  26 Ethanol 10% 3 hrs, larvae L3    24 Caffeine 1.5 mg/ml 4 hrs, larvae L3  (43) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (66) Caffeine 25 mg/ml 48 hrs, 4-day adult  (46) Paraquat 5 mM 48 hrs, 4-day adult  (74) Paraquat 10 mM 48 hrs, 4-day adult  (89) Rotenone 2 μg 12 hrs, larvae L3  (41) Rotenone 8 μg 12 hrs, larvae L3  (42) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    65 cold shock, 4-day adult    51 heat shock, 4-day adult    39 Cadmium 50 mM 6 hrs, larvae L3    26 Cadmium 50 mM 12 hrs, larvae L3    27 Cadmium 50 mM 48 hrs, 4-day adult    39 Cadmium 100 mM 48 hrs, 4-day adult    55 Copper 0.5 mM 12 hrs, larvae L3    14 Copper 15 mM 48 hrs, 4-day adult    50 Zinc 5 mM 12 hrs, larvae L3    24 Zinc 4.5 mM 48 hrs, 4-day adult    71 Ethanol 2.5% 3 hrs, larvae L3    54 Ethanol 5% 3 hrs, larvae L3    26 Ethanol 10% 3 hrs, larvae L3    24 Caffeine 1.5 mg/ml 4 hrs, larvae L3    43 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    66 Caffeine 25 mg/ml 48 hrs, 4-day adult    46 Paraquat 5 mM 48 hrs, 4-day adult    74 Paraquat 10 mM 48 hrs, 4-day adult    89 Rotenone 2 μg 12 hrs, larvae L3    41 Rotenone 8 μg 12 hrs, larvae L3    42 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    65 cold shock, 4-day adult    51 heat shock, 4-day adult    39 Cadmium 50 mM 6 hrs, larvae L3    26 Cadmium 50 mM 12 hrs, larvae L3    27 Cadmium 50 mM 48 hrs, 4-day adult    39 Cadmium 100 mM 48 hrs, 4-day adult    55 Copper 0.5 mM 12 hrs, larvae L3    14 Copper 15 mM 48 hrs, 4-day adult    50 Zinc 5 mM 12 hrs, larvae L3    24 Zinc 4.5 mM 48 hrs, 4-day adult    71 Ethanol 2.5% 3 hrs, larvae L3    54 Ethanol 5% 3 hrs, larvae L3    26 Ethanol 10% 3 hrs, larvae L3    24 Caffeine 1.5 mg/ml 4 hrs, larvae L3    43 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    66 Caffeine 25 mg/ml 48 hrs, 4-day adult    46 Paraquat 5 mM 48 hrs, 4-day adult    74 Paraquat 10 mM 48 hrs, 4-day adult    89 Rotenone 2 μg 12 hrs, larvae L3    41 Rotenone 8 μg 12 hrs, larvae L3    42 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    65 cold shock, 4-day adult    51 heat shock, 4-day adult    39 Cadmium 50 mM 6 hrs, larvae L3    26 Cadmium 50 mM 12 hrs, larvae L3    27 Cadmium 50 mM 48 hrs, 4-day adult    39 Cadmium 100 mM 48 hrs, 4-day adult    55 Copper 0.5 mM 12 hrs, larvae L3    14 Copper 15 mM 48 hrs, 4-day adult    50 Zinc 5 mM 12 hrs, larvae L3    24 Zinc 4.5 mM 48 hrs, 4-day adult    71 Ethanol 2.5% 3 hrs, larvae L3    54 Ethanol 5% 3 hrs, larvae L3    26 Ethanol 10% 3 hrs, larvae L3    24 Caffeine 1.5 mg/ml 4 hrs, larvae L3    43 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    66 Caffeine 25 mg/ml 48 hrs, 4-day adult    46 Paraquat 5 mM 48 hrs, 4-day adult    74 Paraquat 10 mM 48 hrs, 4-day adult    89 Rotenone 2 μg 12 hrs, larvae L3    41 Rotenone 8 μg 12 hrs, larvae L3    42 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (65) cold shock, 4-day adult  (51) heat shock, 4-day adult  (39) Cadmium 50 mM 6 hrs, larvae L3  26 Cadmium 50 mM 12 hrs, larvae L3  27 Cadmium 50 mM 48 hrs, 4-day adult  (39) Cadmium 100 mM 48 hrs, 4-day adult  (55) Copper 0.5 mM 12 hrs, larvae L3    14 Copper 15 mM 48 hrs, 4-day adult  (50) Zinc 5 mM 12 hrs, larvae L3    24 Zinc 4.5 mM 48 hrs, 4-day adult  (71) Ethanol 2.5% 3 hrs, larvae L3  (54) Ethanol 5% 3 hrs, larvae L3  26 Ethanol 10% 3 hrs, larvae L3    24 Caffeine 1.5 mg/ml 4 hrs, larvae L3  (43) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (66) Caffeine 25 mg/ml 48 hrs, 4-day adult  (46) Paraquat 5 mM 48 hrs, 4-day adult  (74) Paraquat 10 mM 48 hrs, 4-day adult  (89) Rotenone 2 μg 12 hrs, larvae L3  (41) Rotenone 8 μg 12 hrs, larvae L3  (42) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    65 cold shock, 4-day adult    51 heat shock, 4-day adult    39 Cadmium 50 mM 6 hrs, larvae L3    26 Cadmium 50 mM 12 hrs, larvae L3    27 Cadmium 50 mM 48 hrs, 4-day adult    39 Cadmium 100 mM 48 hrs, 4-day adult    55 Copper 0.5 mM 12 hrs, larvae L3    14 Copper 15 mM 48 hrs, 4-day adult    50 Zinc 5 mM 12 hrs, larvae L3    24 Zinc 4.5 mM 48 hrs, 4-day adult    71 Ethanol 2.5% 3 hrs, larvae L3    54 Ethanol 5% 3 hrs, larvae L3    26 Ethanol 10% 3 hrs, larvae L3    24 Caffeine 1.5 mg/ml 4 hrs, larvae L3    43 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    66 Caffeine 25 mg/ml 48 hrs, 4-day adult    46 Paraquat 5 mM 48 hrs, 4-day adult    74 Paraquat 10 mM 48 hrs, 4-day adult    89 Rotenone 2 μg 12 hrs, larvae L3    41 Rotenone 8 μg 12 hrs, larvae L3    42 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    65 cold shock, 4-day adult    51 heat shock, 4-day adult    39 Cadmium 50 mM 6 hrs, larvae L3    26 Cadmium 50 mM 12 hrs, larvae L3    27 Cadmium 50 mM 48 hrs, 4-day adult    39 Cadmium 100 mM 48 hrs, 4-day adult    55 Copper 0.5 mM 12 hrs, larvae L3    14 Copper 15 mM 48 hrs, 4-day adult    50 Zinc 5 mM 12 hrs, larvae L3    24 Zinc 4.5 mM 48 hrs, 4-day adult    71 Ethanol 2.5% 3 hrs, larvae L3    54 Ethanol 5% 3 hrs, larvae L3    26 Ethanol 10% 3 hrs, larvae L3    24 Caffeine 1.5 mg/ml 4 hrs, larvae L3    43 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    66 Caffeine 25 mg/ml 48 hrs, 4-day adult    46 Paraquat 5 mM 48 hrs, 4-day adult    74 Paraquat 10 mM 48 hrs, 4-day adult    89 Rotenone 2 μg 12 hrs, larvae L3    41 Rotenone 8 μg 12 hrs, larvae L3    42 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_10 mE1_20_mRNA_expression_cluster_15
External Data & Images
Linkouts	BDGP expression data • GH05411 GH13461 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003748 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9364-RE FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Treh Stages(s) 1-3 Stages(s) 4-6 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | pupal stage, with Scer\GAL4pnr-MD237 TrehGD5118 viable TrehEY06982 TrehEY14712 Sterility Allele fertile TrehEY06982 TrehEY14712 Other Phenotypes Allele planar polarity defective, with Scer\GAL4pnr-MD237 TrehGD5118 visible, with Scer\GAL4pnr-MD237 TrehGD5118 Phenotype manifest in Allele mesothoracic tergum, with Scer\GAL4pnr-MD237 TrehGD5118 trichogen cell, with Scer\GAL4pnr-MD237 TrehGD5118
Classical Alleles ( 19 )
For All Classical Alleles Show
Allele of Treh Class Mutagen Stocks Known lesion Treh5-SZ-3149 1 -- TrehCB-5804-3 1 -- TrehCB-6284-3 1 -- TrehCB-6401-3 1 -- Trehd00379 P-element activity 1 -- Trehd00520 P-element activity 1 -- Trehd01034 P-element activity 1 -- Trehd03022 P-element activity 1 -- TrehEY06982 P-element activity 1 -- TrehEY14712 P-element activity 1 -- TrehKG00995 1 -- TrehMI05512 1 -- TrehMI07210 1 -- Treh122T natural population 0 -- Trehd09232 P-element activity 0 -- TrehEP2152 P-element activity 0 -- Trehf02252 0 -- TrehF 0 -- TrehS 0 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Treh Class Mutagen Stocks Known lesion TrehGD5118 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes TrehNIG.9364R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)Exel6072 (Ryder, 2004.4.26) Df(2R)Exel7167 (Ryder, 2004.4.26)
Duplicated in	Ts(YLt;2Rt)H149+Ts(YLt;2Lt)L107 (Oliver et al., 1978)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD5118} NA P{NIG.9364R} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}TrehEP2152 NA P{EPgy2}TrehEY06982 NA P{EPgy2}TrehEY14712 NA P{XP}Trehd00379 NA P{XP}Trehd00520 NA P{XP}Trehd01034 NA P{XP}Trehd03022 NA P{XP}Trehd09232 NA miscellaneous insertions Mi{MIC}TrehMI05512 NA Mi{MIC}TrehMI07210a NA Mi{MIC}TrehMI07210b NA P{RS3}TrehCB-5804-3 NA P{RS3}TrehCB-6284-3 NA P{RS3}TrehCB-6401-3 NA P{RS5}Treh5-SZ-3149 NA P{SUPor-P}TrehKG00995 NA PBac{WH}Trehf02252 NA
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function
CV term Evidence References
trehalase activity inferred from mutant phenotype (Eanes et al., 2006)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
alpha,alpha-trehalase activity inferred from sequence or structural similarity with UniProtKB:O43280 (assigned by UniProtKB) (Swiss-Prot Project Members, 2003.9.15) inferred from sequence or structural similarity with UniProtKB:P19813 (FlyBase, 1992-) traceable author statement (Choudhary et al., 1992)
Biological Process
CV term Evidence References
trehalose metabolic process inferred from sequence or structural similarity with UniProtKB:O43280 (assigned by UniProtKB) (Swiss-Prot Project Members, 2003.9.15)
Cellular Component
CV term Evidence References
anchored to plasma membrane inferred from sequence or structural similarity with UniProtKB:O43280 (assigned by UniProtKB) (Swiss-Prot Project Members, 2003.9.15)
Sequence Ontology: Class of Gene
	gene_with_edited_transcript (Graveley et al., 2011) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Treh - ATPsyn-γ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Treh - Arc1 experimental knowledge based (Guruharsha et al., 2011) Treh - Arf51F anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Treh - Art8 experimental knowledge based (Guruharsha et al., 2011) Treh - CG1024 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Treh - CG10824 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Treh - CG1105 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Treh - CG1124 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Treh - CG11777 experimental knowledge based (Guruharsha et al., 2011) Treh - CG11796 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Treh - CG1218 experimental knowledge based (Guruharsha et al., 2011) Treh - CG13021 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Treh - CG13321 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Treh - CG13532 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Treh - CG13893 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) Treh - CG14450 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) Treh - CG14543 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Treh - CG1532 experimental knowledge based (Guruharsha et al., 2011) Treh - CG15739 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Treh - CG15743 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Treh - CG17010 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Treh - CG17493 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Treh - CG18081 experimental knowledge based (Guruharsha et al., 2011) Treh - CG18787 experimental knowledge based (Guruharsha et al., 2011) Treh - CG18789 experimental knowledge based (Guruharsha et al., 2011) Treh - CG2540 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Treh - CG2931 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Treh - CG30393 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Treh - CG31235 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Treh - CG31798 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Treh - CG3544 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) Treh - CG3829 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Treh - CG4565 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Treh - CG4603 experimental knowledge based (Guruharsha et al., 2011) Treh - CG5510 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Treh - CG5516 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Treh - CG5872 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Treh - CG5888 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Treh - CG6218 experimental knowledge based (Guruharsha et al., 2011) Treh - CG6337 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Treh - CG6432 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Treh - CG7049 experimental knowledge based (Guruharsha et al., 2011) Treh - CG7669 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Treh - CG7834 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Treh - CG8207 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Treh - CG9630 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Treh - CG9673 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Treh - CG9773 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Treh - CG9780 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Treh - Ccs experimental knowledge based (Guruharsha et al., 2011) Treh - Cpr11B anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Treh - Csat anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Treh - CtBP anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Treh - Eig71Ed anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Treh - Got1 experimental knowledge based (Guruharsha et al., 2011) Treh - GstD4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Treh - HIP-R experimental knowledge based (Guruharsha et al., 2011) Treh - Irc experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) Treh - Lmpt anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Treh - MED22 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Treh - Nup54 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Treh - Patsas experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) Treh - Rae1 experimental knowledge based (Guruharsha et al., 2011) Treh - RpS21 experimental knowledge based (Guruharsha et al., 2011) Treh - Sod experimental knowledge based (Guruharsha et al., 2011) Treh - Tim8 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Treh - Trx-2 experimental knowledge based (Guruharsha et al., 2011) Treh - Vps16B anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Treh - ash2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Treh - beag anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Treh - grsm experimental knowledge based (Guruharsha et al., 2011) Treh - l(2)dtl anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Treh - lark anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Treh - p24-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Treh - papi anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Treh - rhi anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Treh - tau anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Treh allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 69627 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0003748 DroID - A comprehensive database of gene and protein interactions. • FBgn0003748 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 45368
Orthologs
OrthoDB Orthologs (71) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6TXCBM Dipteran inclusive ortholog search EOG6KWK25 Insect inclusive ortholog search EOG6T4BQW Arthropod inclusive ortholog search EOG6CVDPB Metazoa inclusive ortholog search EOG6DZDNC, EOG6B09K1
Orthologs in Drosophila Species (EOG6TXCBM)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Treh     Drosophila simulans   Dsim\GD11560 Y   Drosophila sechellia   Dsec\GM15801 Y   Drosophila erecta   Dere\GG22083 Y   Drosophila yakuba   Dyak\GE12164 Y   Drosophila ananassae   Dana\GF11930 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA25091 Y   Drosophila persimilis   Dper\GL10148 Y   Drosophila willistoni   Dwil\GK23271 Y   Drosophila virilis   Dvir\GJ20400 Y   Drosophila mojavensis   Dmoj\GI20651 Y   Drosophila grimshawi   Dgri\GH21428 Y
Orthologs in non-Drosophila Dipterans (EOG6KWK25)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL009658   Anopheles gambiae Malaria mosquito  Agam\AGAP012053   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ017949   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ006199
Orthologs in non-Dipteran Insects (EOG6T4BQW)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB40897 Y Apis mellifera Western honey bee  Amel\GB43575 Y Apis mellifera Western honey bee  Amel\GB55489 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG008324 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG000895 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH16484 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH11024 Y Atta cephalotes Leafcutter ant  Acep\ACEP20019 Y Atta cephalotes Leafcutter ant  Acep\ACEP10783 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO21247 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO20841 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL21529 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL12379 Y Linepithema humile Argentine ant  Lhum\LH17348 Y Linepithema humile Argentine ant  Lhum\LH19461 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB13869 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB22346 Y Solenopsis invicta Red fire ant  Sinv\SINV15770 Y Solenopsis invicta Red fire ant  Sinv\SINV18355 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI40108 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI004345 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI51051 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI003828 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI007462 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI073040 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI002298 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI008788 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI072210 Y Bombyx mori Silkmoth  Bmor\BGIBMGA005664 Y Bombyx mori Silkmoth  Bmor\BGIBMGA004586 Y Bombyx mori Silkmoth  Bmor\BGIBMGA005665 Y Pediculus humanus Human body louse  Phum\PHUM267740 Y Pediculus humanus Human body louse  Phum\PHUM617010 Y Tribolium castaneum Red flour beetle  Tcas\TC006700 Y Tribolium castaneum Red flour beetle  Tcas\TC004791 Y Tribolium castaneum Red flour beetle  Tcas\TC011571 Y Tribolium castaneum Red flour beetle  Tcas\TC006697 Y Tribolium castaneum Red flour beetle  Tcas\TC006699 Y Tribolium castaneum Red flour beetle  Tcas\TC006698 Y
Orthologs in non-Insect Arthropods (EOG6CVDPB)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_303585 Y Daphnia pulex Water flea  Dpux\JGI_V11_314347 Y Daphnia pulex Water flea  Dpux\L1 Y Daphnia pulex Water flea  Dpux\JGI_V11_308726 Y
Orthologs in non-Arthropod Metazoa (EOG6DZDNC, EOG6B09K1)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\tre-5 Y Caenorhabditis elegans Nematode  Cele\tre-2 Y Caenorhabditis elegans Nematode  Cele\tre-1 Y Caenorhabditis elegans Nematode  Cele\tre-3 Y Caenorhabditis elegans Nematode  Cele\tre-4 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_019288gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_017170gn Y Danio rerio Zebrafish  Drer\treh Y Xenopus tropicalis Western clawed frog  Xtro\treh Y Mus musculus House mouse  Mmus\Treh Y Rattus norvegicus Norway rat  Rnor\Treh Y Homo sapiens Human  Hsap\TREH Y
Human Orthologs (1)
Gene OMIM HGNC Hsap\TREH
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD11560 Drosophila sechellia Dsec\GM15801 Drosophila erecta Dere\GG22083 Drosophila yakuba Dyak\GE12164 Drosophila ananassae Dana\GF11930 Drosophila pseudoobscura pseudoobscura Dpse\GA25091 Drosophila persimilis Dper\GL10148 Drosophila willistoni Dwil\GK23271 Drosophila virilis Dvir\GJ20400 Drosophila mojavensis Dmoj\GI20651 Drosophila grimshawi Dgri\GH21428
Stocks & Reagents
Stocks Listed in FlyBase ( 15 )
Bloomington	21441 y1 w67c23; P{EPgy2}TrehEY14712 41073 y1 w*; Mi{MIC}TrehMI05512/SM6a
Harvard	- P{XP}Trehd00379 - P{XP}Trehd00520 - P{XP}Trehd01034 - P{XP}Trehd03022
Kyoto	123828 w1118; P{RS3}TrehCB-5804-3 124022 w1118; P{RS3}TrehCB-6284-3 124091 w1118; P{RS3}TrehCB-6401-3 125919 w1118; P{RS5}Treh5-SZ-3149
VDRC	v30730 w1118; P{GD5118}v30730 v30731 w1118; P{GD5118}v30731
	More stocks available...
Genomic Clones ( 1 )
	BACR16B07 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 312 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH05411 GH13461
Other clones	DPiM_GH13461
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT02206 AT09212 AT15405 AT16537 GH05309 GH05518 GH08755 GH14783 GH21239 GH27055 GM15839 HL01747 HL03376 HL07413 LD47806 LP07772 LP12122 LP12165 LP21903 RE06175 RE10319 RE13060 RE16119 RE23352 RE23473 RE38925 RE40928 RE48224 RE64218 RE66933 RE70186 RE73505 RH10744 RH13162 RH14314 RH68502 RH69569 SD04824 SD11306 SD17296 SD20024
Other clones	46817 61202 62812 83498 118948 119449 153337 190315 280926 Dmel_dig_018346_0697_3107 Dmel_neb_012573_0673_2611 Dmel_neb_013306_0069_2727 EC40679 EK054332 EK174920 EK185935 EK188357 EK256632 EK292412 EK305740 ESG0115a.B21_B09 FGM303D01 GH23015 RP003002515 RP003013335 RP003013959 RP003015843 RP003025592 RP003042811 RP003049739 RP003054917 RP003055301 RP003055466 RP003063062 RP003067196 RP003067240 RP003069768 RP003075096 RP003076077 RP003078764 RP003079838 RP003079957 RP003084254 RP003085071 RP003091297 RP003094484 RP003095093 RP003096688 RP003100008 RP003103544 RP003105077 RP003105138 RP003105918 RP003105929 RP003106372 RP003113707 RP003115672 RP003117693 RP003120114 RP003120208 RP003120943 RP003122034 RP003124278 RP003127362 RP003130355 RP003132240 RP003133090 RP003142677 RP003143415 RP003157979 RP003160078 RP003160871 RP003160996 RP003165452 RP003166133 RP003169248 RP003170648 RP003177136 RP003183857 RP003189515 RP003194460 RP003200145 RP003201919 RP003204330 RP003206860 RP003214180 RP003217719 RP003220750 RP003221194 RP003221926 RP003222337 RP003222676 RP003223038 RP003225702 RP003228030 RP003228103 RP003232718 RP003236819 RP003238568 RP003241262 RP003242339 RP003243359 RP003249741 RP003249858 RP003251909 RP003252479 RP003253371 RP003255057 RP003262191 RP003265824 RP003270176 RP003271680 RP003272907 RP003272998 RP003274449 RP003276509 RP003283788 RP003290357 RP003291234 RP003292389 RP003293826 RP003300612 RP003301357 RP003304182 RP003305929 RP003306294 RP003310066 RP003312165 RP003313653 RP003315458 RP003316411 RP003318079 RP003318647 RP003318721 RP003318956 RP003320269 RP003320386 RP003324258 RP003325796 RP003326769 RP003327414 RP003329278 RP003330608 RP003330992 RP003331689 RP003335330 RP003335702 RP003338385 RP003342598 RP003345212 RP003345413 RP003345975 RP003346870 RP003346980 RP003347636 RP003348093 RP003351656 RP003356305 RP003360110 RP003360132 RP003366268 RP003369119 RP003371856 RP003373379 RP003376422 RP003382650 RP003388983 RP003402958 RP003405552 RP003406247 RP003406348 RP003411869 RP003420217 RP003431638 RP003441563 RP003442491 RP003445926 RP003446295 RP003455695 RP003456231 RP003457637 RP003473943 RP003475011 RP003479370 RP003481116 RP003489028 RP003490898 RP003491071 RP003491555 RP003491567 RP003492873 RP003492874 RP003494965 RP003495235 RP003498187 RP003501105 RP003501121 RP003502464 RP003502659 RP003513127 RP003516174 RP003520364 RP003527198 RP003531962 RP003532063 RP003533641 RP003534174 RP003534573 RP003534731 RP003535665 RP003538325 RP003545100 RP003545314 RP003550852 RP003553091 RP003554566 RP003555932 RP003556020 RP003560469 RP003565147 RP003566818 RP003567673 RP003570013 RP003574774 RP003575910 RP003578157 RP003580152 RP003580689 RP003581731 RP003583373 RP003584012 RP003584531 RP003597875 RP003600613 RP003601905 RP003603888 RP003609534 RP003612532 RP003616929 RP003621353 RP003623766 RP003623933 RP003629799 RP003631865 RP003639410 RP003642104 RP003649290 RP003650883 RP003651114 RP003656180 RP003657607 RP003658005 RP003658666 RP003661435 RP003662240 RP003663911 RP003665912 RP003670064 RP003673539 RP003673984 RP003674225 RP003674376 RP003678946 RP003679450 RP004220942 RP004237650 RP004356149 RP004498290
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0003748 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 45368
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Treh CG9364 (Misra, 2000.8.9)
Additional comments
Other Comments
	The effects of a high sucrose diet on live weight, total protein, stored lipid and glycogen and crude activities of 12 enzymes involved in energy metabolism are quantified. The activities of many enzymes are reduced by the sucrose treatment. (Wang and Clark, 1995) Mobility variants at Treh are due to allozyme polymorphism. (Burton and la Spada, 1986) This gene was first recognised by a match of an STS sequence from a European Drosophila Genome Mapping Project cosmid.   Structural gene for trehalase (TRE), a hydrolase that splits the sugar trehalose into two glucose molecules. Polyacrylamide gel electrophoresis and isoelectric focusing indicates the presence of one molecular form of the enzyme in flight muscles, hemolymph and abdomens of adult flies. No mutant alleles obtained.
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_080082 NM_166421 NM_166422 NM_166423 NM_166424 NM_166425 NM_001274186 RefSeq (Proteins) • NP_524821 NP_726023 NP_726024 NP_726025 NP_726026 NP_726027 NP_001261115 DDBJ / EMBL / GenBank • AAF46667 AAF46668 AAF46669 AAK92890 AAM68192 AAM68193 AAM68194 AF083507 AF083508 AGB93647 AI135635 AW941768 AY051466 CL527963 CW848267 CZ471563 CZ471642 CZ471643 CZ471986 CZ473138 CZ476628 Z50689 Entrez Gene - A searchable database of RefSeq genes. • 45368 UniProtKB/Swiss-Prot • Q9W2M2 UniProtKB/TrEMBL • A4UZR3
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Glycoside hydrolase, family 37, conserved site (IPR018232) Glycoside hydrolase, family 37 (IPR001661) Six-hairpin glycosidase-like (IPR008928) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GH05411 GH13461
Linkouts
	BioGRID - A database of protein and genetic interactions • 69627 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0003748 DroID - A comprehensive database of gene and protein interactions. • FBgn0003748 DRSC - Results from RNAi screens. • FBgn0003748 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003748 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9364-RE FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0003748 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 45368 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 45368 modMine - Data generated by the modENCODE project. • FBgn0003748
Synonyms & Secondary IDs ( 11 )
Reported As
Symbol Synonym	87D3T (Louis et al., 1997) anon-EST:Posey159   anon-sts38   CG9364 (Mack et al., 2006, Cammarato et al., 2011, Yano et al., 2012) ESTS:87D3T   TRE (Montooth et al., 2003, Clark and Fucito, 1998, Clark and Wang, 1997, Wang and Clark, 1995, Clark, 1994, Clark et al., 1995, Clark et al., 1990, Clark, 1990) Tre (Clark and Wang, 1994) TREH (Choudhary et al., 1992) Treh (Flowers et al., 2007, Choksi et al., 2006, Laayouni et al., 2007, Liu and Lehmann, 2008, Dierick and Greenspan, 2006, Kent et al., 2009, Betz and Darnell, 2006, Eanes et al., 2006, Wallace et al., 2010, Japanese National Institute of Genetics, 2012.5.21)
Name Synonym	trehalase (Montooth et al., 2003, Musselman et al., 2011, Laayouni et al., 2007, Kent et al., 2009) Trehalase (Cammarato et al., 2011, Yano et al., 2012)
Secondary FlyBase IDs
	FBgn0014436 FBgn0025313 FBgn0034584
References ( 57 )
Generate a list of	All references relating to this gene ( 57 )
List References by type	Research paper  ( 29 ) Supplementary material  ( 7 ) Review  ( 1 ) Personal communication to FlyBase  ( 10 ) Abstract  ( 2 ) FlyBase analysis  ( 3 ) Stock list  ( 1 ) Protein sequence record  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 1 ) Book  ( 1 )
Recent research papers ( 4 )
	Vesala et al., 2012, Insect Mol. Biol. 21(1): 107--118 Cold tolerance and cold-induced modulation of gene expression in two Drosophila virilis group species with different distributions. [FBrf0217233] Yano et al., 2012, J. Neurogenet. 26(1): 53--63 Identification of proteasome components required for apical localization of chaoptin using functional genomics. [FBrf0217843] Baycin-Hizal et al., 2011, J. Proteome Res. 10(6): 2777--2784 GlycoFly: A Database of Drosophila N-linked Glycoproteins Identified Using SPEG-MS Techniques. [FBrf0213834] Musselman et al., 2011, Dis. Model Mech. 4(6): 842--849 A high-sugar diet produces obesity and insulin resistance in wild-type Drosophila. [FBrf0216626] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...