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Gene Dmel\ttk

General Information
Symbol	Dmel\ttk	Species	D. melanogaster
Name	tramtrack	Annotation symbol	CG1856
Feature type	protein_coding_gene	FlyBase ID	FBgn0003870
Gene Model Status	Current	Stock availability	49 publicly available
Also Known As	ttk69, TTK88, E(yan)100D, FTZ-F2, oss, osn
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	100D1-100D1	Sequence location	3R:27,539,591..27,561,114 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene tramtrack is referred to in FlyBase by the symbol Dmel\ttk (CG1856, FBgn0003870). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; RNA polymerase II core promoter proximal region sequence-specific DNA binding; protein binding; RNA polymerase II distal enhancer sequence-specific DNA binding; chromatin binding; protein homodimerization activity. There is experimental evidence for 22 unique biological process terms, many of which group under: anatomical structure development; biological regulation; open tracheal system development; cellular component organization or biogenesis; sensory organ development; cellular process involved in reproduction; organ morphogenesis; regulation of cellular macromolecule biosynthetic process; compound eye photoreceptor development; regulation of developmental process. 157 alleles are reported. The phenotypes of these alleles are annotated with: organ system subdivision; external compound sense organ; nervous system; adult segment; peripheral nervous system; multi-cell-component structure; presumptive embryonic/larval nervous system; cuticle; imaginal precursor; eo support cell; taenidial fold; larval abdominal segment 5. It has 8 annotated transcripts and 8 annotated polypeptides. Protein features are: AT hook, DNA-binding motif; BTB/POZ; BTB/POZ fold; BTB/POZ-like; Zinc finger, C2H2; Zinc finger, C2H2-like; Zinc finger, C2H2-type/integrase, DNA-binding. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 06-18 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult salivary gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult crop, larval/adult midgut, larval/adult hindgut, larval Malpighian tubules, adult heart, larval/adult fat body, larval salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Gene sequence location is 3R:27539591..27561114.
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	Ttk: Tramtrack Gene encodes a zinc-finger protein binding to a number of sites involved in the transcriptional control of fushi-tarazu in the Antennapedia complex.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	Alleles ttk[MI03530] Insertions Mi{MIC}ttk[MI03530] References Bellen, 2011.9.26, MI948.xml
FB2012_01	References Carreira et al., 2011, BMC Dev. Biol. 11: 32 Cunha et al., 2010, PLoS Genet. 6: e1001014 Sequence features HFA14078 HFA17091 BKN30420 Controlled Vocabulary Terms transcriptional repressor complex positive regulation of transcription from RNA polymerase II promoter RNA polymerase II distal enhancer sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 100D1-100D1   Limits computationally determined from genome sequence between P{EP}pygoEP1076 and P{PZ}ttk02667&P{lacW}ttkj6C7
Experimentally Determined Cytological Location
Cytogenetic map Notes References 100D1-100D2   (determined by in situ hybridisation)   (Spradling et al., 1999) 100D-100D   (determined by in situ hybridisation)   (Szeged Stock Center, 1998-) 100D-100D   (determined by in situ hybridisation)   (Salzberg et al., 1997) 100D-100D   (determined by in situ hybridisation)   (Deak et al., 1997) 100D1-100D2   (determined by in situ hybridisation)   (Giesen et al., 1997) 100D1-100D2   (determined by in situ hybridisation)   (Lai et al., 1996) 100D-100D   (determined by in situ hybridisation)   (Brown, 1992) 100D1-100D2   100D2--3   (BDGP Project Members, 1994-1999) 100D-100D   (determined by in situ hybridisation)   (Xiong and Montell, 1993) 100D-100D   (determined by in situ hybridisation)   (Brown et al., 1991) 100D3-100D4   (determined by in situ hybridisation)   (Harrison and Travers, 1990)
Experimentally Determined Recombination Data
Location	3-102.7 (Salzberg et al., 1994) 3- (Horn et al., 2003)
Left of (cM)
Right of (cM)	Med (Hudson et al., 1998)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\ttk for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) ttk-RA FBtr0085829  NM_170564   3589   813 ttk-RB FBtr0085827  NM_170565   3820   813 ttk-RC FBtr0085828  NM_080172   4484   643 ttk-RD FBtr0085830  NM_170567   4253   643 ttk-RE FBtr0085825  NM_170566   3898   813 ttk-RF FBtr0085826  NM_170568   4562   643 ttk-RG FBtr0303227  NM_001202400   3588   813 ttk-RH FBtr0303228  NM_001202401   4252   643
Additional Transcript Data & Comments
Reported size (kB)	5.0, 4.2 (northern blot) (Xiong and Montell, 1993) 4.2 (longest cDNA) (Read and Manley, 1992)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein ttk-PA   FBpp0085190   88.4   813   6.19     NP_733443   AAF57180 ttk-PB   FBpp0085188   88.4   813   6.19     NP_733444   AAF57179 ttk-PC   FBpp0085189   68.8   643   7.65     NP_524911   AAF57182 ttk-PD   FBpp0085191   68.8   643   7.65     NP_733446   AAF57181 ttk-PE   FBpp0085186   88.4   813   6.19     NP_733445   AAN14282 ttk-PF   FBpp0085187   68.8   643   7.65     NP_733447   AAN14283 ttk-PG   FBpp0292319   88.4   813   6.19     NP_001189329   ADV37419 ttk-PH   FBpp0292320   68.8   643   7.65     NP_001189330   ADV37420
Additional Polypeptide Data & Comments
Reported size (kDa)	813, 643 (aa); 88, 69 (kD predicted) (Xiong and Montell, 1993) 811, 641 (aa); 97 (kD observed); 88 (kD predicted) (Read and Manley, 1992) 641 (aa); 69 (kD predicted) (Harrison and Travers, 1990) 641 (aa) (Brown et al., 1991)
Comments	As absence of ttk+P811 correlates with supernumerary R7 photoreceptor cells, this protein may be required for suppression of genes which promote the R7 fate. (Xiong and Montell, 1993) ttk+P641 may repress expression of genes incompatible with the photoreceptor cell fate. (Xiong and Montell, 1993) Although the ttk+P641 protein has a predicted molecular weight of 69kD, it runs at about 97 kD on a polyacrylamide-SDS gel. The zinc finger motifs, and the consensus DNA binding sites of the ttk+P881 and ttk+P641 proteins differ. The ttk+P641 protein binds sites in the eve promoter and autoregulatory element, while the ttk+P881 protein binds a region in the en promoter. (Read and Manley, 1992) The ttk+P881 protein has a predicted molecular weight of 88 kD, although it runs about 50% slower than predicted on a polyacrylamide-SDS gel. The consensus DNA binding sites of the ttk+P881 and ttk+P641 proteins differ. The ttk+P641 protein binds sites in the eve promoter and autoregulatory element, while the ttk+P881 protein binds a region in the en promoter. (Read and Manley, 1992) Three binding sites for ttk protein were detected in the ftz zebra element. Three additional binding sites were detected in the ftz promoter region. (Harrison and Travers, 1990)
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • AT hook, DNA-binding motif (IPR017956) BTB/POZ fold (IPR011333) Zinc finger, C2H2-type/integrase, DNA-binding (IPR013087) Zinc finger, C2H2-like (IPR015880) BTB/POZ-like (IPR000210) Zinc finger, C2H2 (IPR007087) BTB/POZ (IPR013069) PDB - Protein Data Bank. An information portal to biological macromolecular structures • 2DRP
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141202   AA141203   AA390579   AA392395   AA441484   AA695379   AA696379   AA697110   AA950222   AE014297 AAF57179   AE014297 AAF57180   AE014297 AAF57181   AE014297 AAF57182   AE014297 AAN14282   AE014297 AAN14283   AE014297 ADV37419   AE014297 ADV37420   AF006649   AI124297   AI238209   AI258039   AI260063   AI532881   AI533657   AQ025128   AQ034094   AQ073312   AW941964   AW942904   AY094762 AAM11115   AY122169 AAM52681   AY863929   AY863930   AY863931   AY863932   AY863933   AY863934   AY863935   AY863936   AY863937   AY863938   AY863939   AY863940   AY863941   AY863942   AY863943   AY863944   AY863945   AY863946   AY863947   AY863948   AY863949   AY863950   AY863951   BF486941   BF498667   BI161772   BI161773   BI163305   BI164804   BI166318   BI167989   BI170311   BI171259   BI227822   BI228898   BI228901   BI229661   BI235078   BI238162   BI238371   BI238427   BI356109   BI357077   BI357087   BI361688   BI362314   BI362647   BI366138   BI371469   BI373830   BI374086   BI375436   BI481914   BI482134   BI483924   BI484659   BI485958   BI574369   BI577169   BP541496   BP546131   BT001723 AAN71478   BT023939   BT025183   CA806431   CK131440   CK661486   CO177363   CO178012   CO179644   CO186275   CO188089   CO188496   CO188905   CO261921   CO267218   CO271104   CO271324   CO273344   CO273503   CO273581   CO274924   CO275008   CO277438   CO278289   CO279950   CO280174   CO281846   CO282530   CO283173   CO283450   CO289434   CO292637   CO292799   CO294128   CO294516   CO294754   CO294887   CO299553   CO300392   CO302549   CO303276   CO303582   CO304467   CO308777   CO309078   CO310886   CO311810   CO313027   CO313885   CO314077   CO314134   CO316331   CO316801   CO318433   CO318665   CO320916   CO321957   CO322853   CO325470   CO331571   CO332128   CO332234   CO333626   CO339127   CO339977   CO340237   CO340502   CO340647   CO340806   CZ466544   CZ466640   CZ466793   CZ467174   CZ467212   CZ472781   CZ472821   CZ473573   CZ473597   CZ475463   CZ475516   CZ475873   CZ476673   CZ477956   CZ481474   CZ481476   CZ482791   CZ486388   CZ487832   EC051006   EC057111   EC061769   EC062021   EC063064   EC063824   EC066315   EC071752   EC072562   EC073267   EC076380   EC077049   EC078018   EC078288   EC079235   EC079988   EC081050   EC082293   EC082968   EC087992   EC195158   EC197994   EC198647   EC199202   EC201172   EC201380   EC203986   EC208379   EC210942   EC211153   EC211781   EC212470   EC214124   EC214498   EC216048   EC218097   EC219089   EC220275   EC224119   EC224382   EC224603   EC227714   EC231914   EC232470   EC237257   EC237353   EC238258   EC238875   EC238958   EC239644   EC240920   EC241097   EC241208   EC243343   EC243853   EC244796   EC245674   EC247187   EC247779   EC248584   EC249808   EC251014   EC251092   EC253302   EC253374   EC257056   EC258885   EC259250   EL875364   EL875365   EL884090   EL884208   EL884209   EV600504   GH963407   GH982828   M62856 AAA28544   X17121 CAA34981   X71626 CAA50633   X71627 CAA50634   Z11723 CAA77785   Z11723 CAA77786
UniProtKB/Swiss-Prot	P17789 P42282
UniProtKB/TrEMBL	Q8T3M3
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 4   organism | ubiquitous   (Read and Manley, 1992) organism   • yolk plasma | posterior (Lecuyer et al., 2007) embryonic stage 5   pole cell   (Lecuyer et al., 2007) gastrula stage   yolk nucleus | restricted   (Read and Manley, 1992) embryonic stage 7 -- 17   anterior midgut primordium   (Harrison and Travers, 1990) pole cell   (Harrison and Travers, 1990) embryonic stage 8 -- 17   posterior midgut primordium   (Harrison and Travers, 1990) extended germ band stage   posterior midgut primordium   (Read and Manley, 1992) anterior midgut primordium   (Read and Manley, 1992) stomodeum   (Read and Manley, 1992) tracheal pit   (Read and Manley, 1992) embryonic stage 9   organism | segment polarity expression pattern   (Harrison and Travers, 1990) embryonic stage 9 -- 11   ectoderm | restricted   (Harrison and Travers, 1990) mesoderm | restricted   (Harrison and Travers, 1990) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage | early     (Harrison and Travers, 1990) adult stage     (Harrison and Travers, 1990)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage 11   glioblast | subset of ventral nerve cord primordium   (Badenhorst, 2001) Comment:specific to short isoform embryonic stage 11 -- 15   interface glial cell of ventral nerve cord primordium   (Badenhorst, 2001) Comment:specific to short isoform embryonic stage 16 -- 17   CNS glial cell   (Badenhorst, 2001) Comment:specific to short isoform pupal stage   vibrissae | subset   (Lai and Li, 1999) tertiary pigment cell   (Lai and Li, 1999) primary pigment cell   (Lai and Li, 1999) secondary pigment cell   (Lai and Li, 1999) cone cell   (Lai and Li, 1999) pupal stage P6   eo support cell   (Lehembre et al., 2000) Comment:24 hr APF pupal stage P7 -- pharate adult stage P15   photoreceptor cell   (Lai and Li, 1999) Comment:reference states >=36 hr
Additional Descriptive Data
	Both the 69 and 88 kD ttk protein isoforms are detected in pupal cone cells and pigment cells, but only the 69 kD isoform is detected in pupal photoreceptor cells. (Lai and Li, 1999) Both the 69 and 88 kD ttk protein isoforms are detected in pupal cone cells and pigment cells, but only the 69 kD isoform is detected in pupal photoreceptor cells. (Lai and Li, 1999) 69 kD ttk protein is expressed in embryonic glial cells later than repo protein. Highest expression of 69 kD ttk is observed when longitudinal glioblasts have migrated to their correct positions. 69 kD ttk is expressed in all mature glial cells of the embryonic central nervous system. 69 kD ttk is not detected in glioblasts undergoing DNA replication. (Badenhorst, 2001)
Marker for
Subcellular Localization
CV Term	nucleus (Lai and Li, 1999)
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0003870    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0003870 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 06-18 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0003870 expression level Developmental Stage   Expression Level embryo 00-02hr    1851 embryo 02-04hr    646 embryo 04-06hr    1945 embryo 06-08hr    6832 embryo 08-10hr    9156 embryo 10-12hr    7067 embryo 12-14hr    6708 embryo 14-16hr    2930 embryo 16-18hr    1660 embryo 18-20hr    907 embryo 20-22hr    568 embryo 22-24hr    665 larva L1    940 larva L2    840 larva L3 12hr old    517 larva L3 puffstage 1-2    367 larva L3 puffstage 3-6    815 larva L3 puffstage 7-9    1196 white prepupae new    1780 white prepupae 12hr    1009 white prepupae 24hr    2700 pupae 2d postWPP    1808 pupae 3d postWPP    1330 pupae 4d postWPP    700 adult male 01day    710 adult male 05day    677 adult male 30day    694 adult female 01day    1339 adult female 05day    1975 adult female 30day    1936 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1851) embryo 02-04hr  (646) embryo 04-06hr  (1945) embryo 06-08hr  (6832) embryo 08-10hr  (9156) embryo 10-12hr  (7067) embryo 12-14hr  (6708) embryo 14-16hr  (2930) embryo 16-18hr  (1660) embryo 18-20hr  (907) embryo 20-22hr  (568) embryo 22-24hr  (665) larva L1  (940) larva L2  (840) larva L3 12hr old  (517) larva L3 puffstage 1-2  (367) larva L3 puffstage 3-6  (815) larva L3 puffstage 7-9  (1196) white prepupae new  (1780) white prepupae 12hr  (1009) white prepupae 24hr  (2700) pupae 2d postWPP  (1808) pupae 3d postWPP  (1330) pupae 4d postWPP  (700) adult male 01day  (710) adult male 05day  (677) adult male 30day  (694) adult female 01day  (1339) adult female 05day  (1975) adult female 30day  (1936) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (1851) embryo 02-04hr    646 embryo 04-06hr  (1945) embryo 06-08hr  (6832) embryo 08-10hr  (9156) embryo 10-12hr  (7067) embryo 12-14hr  (6708) embryo 14-16hr  (2930) embryo 16-18hr  (1660) embryo 18-20hr    907 embryo 20-22hr    568 embryo 22-24hr    665 larva L1    940 larva L2    840 larva L3 12hr old    517 larva L3 puffstage 1-2    367 larva L3 puffstage 3-6    815 larva L3 puffstage 7-9    1196 white prepupae new  (1780) white prepupae 12hr    1009 white prepupae 24hr  (2700) pupae 2d postWPP  (1808) pupae 3d postWPP    1330 pupae 4d postWPP    700 adult male 01day    710 adult male 05day    677 adult male 30day    694 adult female 01day    1339 adult female 05day  (1975) adult female 30day  (1936) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1851 embryo 02-04hr    646 embryo 04-06hr    1945 embryo 06-08hr    6832 embryo 08-10hr    9156 embryo 10-12hr    7067 embryo 12-14hr    6708 embryo 14-16hr    2930 embryo 16-18hr    1660 embryo 18-20hr    907 embryo 20-22hr    568 embryo 22-24hr    665 larva L1    940 larva L2    840 larva L3 12hr old    517 larva L3 puffstage 1-2    367 larva L3 puffstage 3-6    815 larva L3 puffstage 7-9    1196 white prepupae new    1780 white prepupae 12hr    1009 white prepupae 24hr    2700 pupae 2d postWPP    1808 pupae 3d postWPP    1330 pupae 4d postWPP    700 adult male 01day    710 adult male 05day    677 adult male 30day    694 adult female 01day    1339 adult female 05day    1975 adult female 30day    1936 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1851 embryo 02-04hr    646 embryo 04-06hr    1945 embryo 06-08hr    6832 embryo 08-10hr    9156 embryo 10-12hr    7067 embryo 12-14hr    6708 embryo 14-16hr    2930 embryo 16-18hr    1660 embryo 18-20hr    907 embryo 20-22hr    568 embryo 22-24hr    665 larva L1    940 larva L2    840 larva L3 12hr old    517 larva L3 puffstage 1-2    367 larva L3 puffstage 3-6    815 larva L3 puffstage 7-9    1196 white prepupae new    1780 white prepupae 12hr    1009 white prepupae 24hr    2700 pupae 2d postWPP    1808 pupae 3d postWPP    1330 pupae 4d postWPP    700 adult male 01day    710 adult male 05day    677 adult male 30day    694 adult female 01day    1339 adult female 05day    1975 adult female 30day    1936 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0003870 expression level Developmental Stage   Expression Level embryo 00-02hr    1851 embryo 02-04hr    646 embryo 04-06hr    1945 embryo 06-08hr    6832 embryo 08-10hr    9156 embryo 10-12hr    7067 embryo 12-14hr    6708 embryo 14-16hr    2930 embryo 16-18hr    1660 embryo 18-20hr    907 embryo 20-22hr    568 embryo 22-24hr    665 larva L1    940 larva L2    840 larva L3 12hr old    517 larva L3 puffstage 1-2    367 larva L3 puffstage 3-6    815 larva L3 puffstage 7-9    1196 white prepupae new    1780 white prepupae 12hr    1009 white prepupae 24hr    2700 pupae 2d postWPP    1808 pupae 3d postWPP    1330 pupae 4d postWPP    700 adult male 01day    710 adult male 05day    677 adult male 30day    694 adult female 01day    1339 adult female 05day    1975 adult female 30day    1936 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1851) embryo 02-04hr  (646) embryo 04-06hr  (1945) embryo 06-08hr  (6832) embryo 08-10hr  (9156) embryo 10-12hr  (7067) embryo 12-14hr  (6708) embryo 14-16hr  (2930) embryo 16-18hr  (1660) embryo 18-20hr  (907) embryo 20-22hr  (568) embryo 22-24hr  (665) larva L1  (940) larva L2  (840) larva L3 12hr old  (517) larva L3 puffstage 1-2  (367) larva L3 puffstage 3-6  (815) larva L3 puffstage 7-9  (1196) white prepupae new  (1780) white prepupae 12hr  (1009) white prepupae 24hr  (2700) pupae 2d postWPP  (1808) pupae 3d postWPP  (1330) pupae 4d postWPP  (700) adult male 01day  (710) adult male 05day  (677) adult male 30day  (694) adult female 01day  (1339) adult female 05day  (1975) adult female 30day  (1936) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  1851 embryo 02-04hr    646 embryo 04-06hr  1945 embryo 06-08hr  (6832) embryo 08-10hr  (9156) embryo 10-12hr  (7067) embryo 12-14hr  (6708) embryo 14-16hr  (2930) embryo 16-18hr  1660 embryo 18-20hr    907 embryo 20-22hr    568 embryo 22-24hr    665 larva L1    940 larva L2    840 larva L3 12hr old    517 larva L3 puffstage 1-2    367 larva L3 puffstage 3-6    815 larva L3 puffstage 7-9    1196 white prepupae new  1780 white prepupae 12hr    1009 white prepupae 24hr  (2700) pupae 2d postWPP  1808 pupae 3d postWPP    1330 pupae 4d postWPP    700 adult male 01day    710 adult male 05day    677 adult male 30day    694 adult female 01day    1339 adult female 05day  1975 adult female 30day  1936 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1851 embryo 02-04hr    646 embryo 04-06hr    1945 embryo 06-08hr    6832 embryo 08-10hr    9156 embryo 10-12hr    7067 embryo 12-14hr    6708 embryo 14-16hr    2930 embryo 16-18hr    1660 embryo 18-20hr    907 embryo 20-22hr    568 embryo 22-24hr    665 larva L1    940 larva L2    840 larva L3 12hr old    517 larva L3 puffstage 1-2    367 larva L3 puffstage 3-6    815 larva L3 puffstage 7-9    1196 white prepupae new    1780 white prepupae 12hr    1009 white prepupae 24hr    2700 pupae 2d postWPP    1808 pupae 3d postWPP    1330 pupae 4d postWPP    700 adult male 01day    710 adult male 05day    677 adult male 30day    694 adult female 01day    1339 adult female 05day    1975 adult female 30day    1936 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1851 embryo 02-04hr    646 embryo 04-06hr    1945 embryo 06-08hr    6832 embryo 08-10hr    9156 embryo 10-12hr    7067 embryo 12-14hr    6708 embryo 14-16hr    2930 embryo 16-18hr    1660 embryo 18-20hr    907 embryo 20-22hr    568 embryo 22-24hr    665 larva L1    940 larva L2    840 larva L3 12hr old    517 larva L3 puffstage 1-2    367 larva L3 puffstage 3-6    815 larva L3 puffstage 7-9    1196 white prepupae new    1780 white prepupae 12hr    1009 white prepupae 24hr    2700 pupae 2d postWPP    1808 pupae 3d postWPP    1330 pupae 4d postWPP    700 adult male 01day    710 adult male 05day    677 adult male 30day    694 adult female 01day    1339 adult female 05day    1975 adult female 30day    1936 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0003870    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0003870 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult salivary gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult crop, larval/adult midgut, larval/adult hindgut, larval Malpighian tubules, adult heart, larval/adult fat body, larval salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Heatmap Tissue   Expression Level Larval Central Nervous System no informative data Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary no informative data Adult Testis no informative data Adult Male Accessory Gland no informative data Adult Carcass no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_31
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003870 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1856-RF;CG1856-RE FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for ttk Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele cell lethal | somatic clone ttk804 lethal, with Scer\GAL429BD ttkGS3026 ttkGS3069 ttkGS3165 lethal, with Scer\GAL4c355 ttkGS3026 ttkGS3069 ttkGS3165 lethal, with Scer\GAL4cb01 ttkp69.Scer\UAS ttkp88.Scer\UAS lethal, with Scer\GAL4cb04 ttkp69.Scer\UAS lethal, with Scer\GAL4cb06 ttkp69.Scer\UAS ttkp88.Scer\UAS lethal, with Scer\GAL4cb07 ttkp69.Scer\UAS lethal, with Scer\GAL4cb08 ttkp69.Scer\UAS ttkp88.Scer\UAS lethal, with Scer\GAL4cb09 ttkp69.Scer\UAS lethal, with Scer\GAL4cb10 ttkp69.Scer\UAS lethal, with Scer\GAL4cb13 ttkp69.Scer\UAS ttkp88.Scer\UAS lethal, with Scer\GAL4cb15 ttkp69.Scer\UAS lethal, with Scer\GAL4cb20 ttkp69.Scer\UAS lethal, with Scer\GAL4cb21 ttkp69.Scer\UAS lethal, with Scer\GAL4cb22 ttkp69.Scer\UAS ttkp88.Scer\UAS lethal, with Scer\GAL4cb24 ttkp69.Scer\UAS lethal, with Scer\GAL4cb26 ttkp69.Scer\UAS ttkp88.Scer\UAS lethal, with Scer\GAL4cb27 ttkp88.Scer\UAS lethal, with Scer\GAL4cb28 ttkp69.Scer\UAS lethal, with Scer\GAL4cb29 ttkp69.Scer\UAS lethal, with Scer\GAL4cb30 ttkp69.Scer\UAS ttkp88.Scer\UAS lethal, with Scer\GAL4cb31 ttkp88.Scer\UAS lethal, with Scer\GAL4cb32 ttkp69.Scer\UAS ttkp88.Scer\UAS lethal, with Scer\GAL4cb35 ttkp88.Scer\UAS lethal, with Scer\GAL4cb36 ttkp88.Scer\UAS lethal, with Scer\GAL4cb39 ttkp69.Scer\UAS lethal, with Scer\GAL4dpp.blk1 ttkGS3026 ttkGS3069 ttkGS3165 lethal, with Scer\GAL4hs.2sev ttkGS3026 ttkGS3069 ttkGS3165 lethal | embryonic stage ttk1e11 lethal | embryonic stage | recessive ttk1e11 ttk00219 ttkosn ttkrM730 ttkS025025 ttkS043831 ttkS070207 ttkS104907 ttkS111904 ttkS118416 ttkS120905 ttkS120910 ttkS126010 ttkS128104 ttkS132515 ttkS137208a ttkS139614b ttkS141806a ttkS141811 ttkS142402 ttkS144802c lethal | pupal stage | heat sensitive ttk69.hs lethal | recessive ttk150 ttk01316 ttk02667 ttk03540 ttk05125 ttk05311 ttk05420 ttk10556 ttkB330 ttkbose45 ttkE389 ttkj2A1 ttkj7B8 ttkS003717 ttkS025025 ttkS043831 ttkS070207 ttkS104907 ttkS111904 ttkS118416 ttkS120905 ttkS120910 ttkS126010 ttkS128104 ttkS132515 ttkS137208a ttkS139614b ttkS141806a ttkS144802c semi-lethal ttk02667 semi-lethal | recessive ttk02667 viable ttk1 ttkCB02274 viable, with Scer\GAL4cb03 ttkp69.Scer\UAS ttkp88.Scer\UAS viable, with Scer\GAL4cb04 ttkp88.Scer\UAS viable, with Scer\GAL4cb05 ttkp69.Scer\UAS ttkp88.Scer\UAS viable, with Scer\GAL4cb07 ttkp88.Scer\UAS viable, with Scer\GAL4cb09 ttkp88.Scer\UAS viable, with Scer\GAL4cb10 ttkp88.Scer\UAS viable, with Scer\GAL4cb11 ttkp69.Scer\UAS ttkp88.Scer\UAS viable, with Scer\GAL4cb12 ttkp69.Scer\UAS ttkp88.Scer\UAS viable, with Scer\GAL4cb15 ttkp88.Scer\UAS viable, with Scer\GAL4cb17 ttkp69.Scer\UAS ttkp88.Scer\UAS viable, with Scer\GAL4cb18 ttkp88.Scer\UAS viable, with Scer\GAL4cb19 ttkp69.Scer\UAS ttkp88.Scer\UAS viable, with Scer\GAL4cb20 ttkp88.Scer\UAS viable, with Scer\GAL4cb23 ttkp69.Scer\UAS ttkp88.Scer\UAS viable, with Scer\GAL4cb25 ttkp69.Scer\UAS viable, with Scer\GAL4cb27 ttkp69.Scer\UAS viable, with Scer\GAL4cb28 ttkp88.Scer\UAS viable, with Scer\GAL4cb29 ttkp88.Scer\UAS viable, with Scer\GAL4cb31 ttkp69.Scer\UAS viable, with Scer\GAL4cb34 ttkp69.Scer\UAS ttkp88.Scer\UAS viable, with Scer\GAL4cb35 ttkp69.Scer\UAS viable, with Scer\GAL4cb36 ttkp69.Scer\UAS viable, with Scer\GAL4cb37 ttkp69.Scer\UAS viable, with Scer\GAL4cb38 ttkp69.Scer\UAS viable, with Scer\GAL4cb40 ttkp69.Scer\UAS ttkp88.Scer\UAS viable, with Scer\GAL4pnr-MD237 ttkGD4414 Sterility Allele female sterile ttktwp Other Phenotypes Allele behavior defective | recessive ttkBG01491 cell shape defective ttktwp cell shape defective | somatic clone ttk1e11 decreased cell size | somatic clone, with Scer\GAL4e22c ttkp69.Scer\UAS mitotic cell cycle defective | somatic clone ttk1e11 neuroanatomy defective ttk03A ttkdsRNA.cIa ttkrM730 neuroanatomy defective, with Scer\GAL47B ttkUY181 ttkUY2545 ttkUY4606 neuroanatomy defective, with Scer\GAL4c739 ttkp69.Scer\UAS ttkUY181 stress response defective ttkBG01491 visible ttk1 ttk88.GMR.T:Hsap\MYC ttk88.hs.sev.T:Hsap\MYC visible, with Scer\GAL4Eq1 ttkp69.Scer\UAS visible, with Scer\GAL4ey.PB ttkp69.Scer\UAS visible, with Scer\GAL4ey.PH ttk69.PPDLS.AAAAS.Scer\UAS.T:Ivir\HA1 ttk69.Scer\UAS.T:Ivir\HA1 visible, with Scer\GAL4hs.2sev ttk69.PPDLS.AAAAS.Scer\UAS.T:Ivir\HA1 ttk69.Scer\UAS.T:Ivir\HA1 ttk69.ΔN153.Scer\UAS visible, with Scer\GAL4pnr-MD237 ttkGD4414 visible | dominant ttk88.GMR.T:Hsap\MYC visible | recessive ttk02667 visible | semidominant ttk1 visible | somatic clone ttk1e11 ttkrM730 ttktwp visual behavior defective | recessive ttk1 Phenotype manifest in Allele abdominal 1 lateral pentascolopidial chordotonal organ lch5 ttkdsRNA.cKa abdominal 1 lch5 neuron ttk1e11 ttkdsRNA.cKa abdominal 2 lateral pentascolopidial chordotonal organ lch5 ttkdsRNA.cKa abdominal 2 lch5 neuron ttk1e11 ttkdsRNA.cKa abdominal 3 lateral pentascolopidial chordotonal organ lch5 ttkdsRNA.cKa abdominal 3 lch5 neuron ttk1e11 ttkdsRNA.cKa abdominal 4 lateral pentascolopidial chordotonal organ lch5 ttkdsRNA.cKa abdominal 4 lch5 neuron ttk1e11 ttkdsRNA.cKa abdominal 5 lateral pentascolopidial chordotonal organ lch5 ttkdsRNA.cKa abdominal 5 lch5 neuron ttk1e11 ttkdsRNA.cKa abdominal 6 lateral pentascolopidial chordotonal organ lch5 ttkdsRNA.cKa abdominal 6 lch5 neuron ttk1e11 ttkdsRNA.cKa abdominal 7 lateral pentascolopidial chordotonal organ lch5 ttkdsRNA.cKa abdominal 7 lch5 neuron ttk1e11 ttkdsRNA.cKa abdominal dorsal multidendritic neuron ddaE & dendrite ttk03A abdominal lateral pentascolopidial chordotonal organ lch5 ttkrM730 chemosensory ventral triple row bristle, with Scer\GAL4Bx-MS1096 ttk69.Scer\UAS ttkp88.Scer\UAS chordotonal organ | heat sensitive ttk69.hs commissure ttkD2-50 ttkunspecified cone cell, with Scer\GAL4GMR.PF ttkp69.Scer\UAS cone cell | P-stage | somatic clone ttk1e11 cone cell | somatic clone | third instar larval stage ttk1e11 ttkrM730 cone cell | supernumerary, with Scer\GAL4hs.2sev ttk69.Scer\UAS.T:Ivir\HA1 cone cell | third instar larval stage, with Scer\GAL4GMR.PF ttkp69.Scer\UAS cone cell | third instar larval stage, with Scer\GAL4lz-gal4 ttkp69.Scer\UAS dorsal appendage ttktwp dorsal appendage | maternal effect ttktwp dorsal appendage | maternal effect (with Df(3R)awd-KRB) ttktwp dorsal appendage | maternal effect (with ttk1) ttk1e11 ttktwp dorsal appendage | maternal effect (with ttk1e11) ttk1 ttktwp dorsal appendage | maternal effect (with ttktwp) ttk1 ttk1e11 dorsal appendage | somatic clone ttk1e11 ttktwp dorsal mesothoracic disc & sensory mother cell, with Scer\GAL4Bx-MS1096 ttk69.ΔSA.Scer\UAS ttk69.286-ZFS.Scer\UAS ttk69.BTB-R113.Scer\UAS ttk69.BTB-ZF.Scer\UAS dorsal multidendritic neuron ddaE & dendrite ttk03A dorsal triple row, with Scer\GAL4Bx-MS1096 ttk69.ΔBTB.Scer\UAS ttk69.ΔSA.Scer\UAS ttk69.286-ZFS.Scer\UAS ttk69.BTB-R113.Scer\UAS ttk69.BTB-ZF.Scer\UAS ttk69.BTB-ZFS.Scer\UAS ttk69.D32A.B.Scer\UAS ttk69.K46E.Scer\UAS ttk69.R113.Scer\UAS ttk69.S35A.Scer\UAS ttk69.Scer\UAS ttkp88.Scer\UAS egg | maternal effect ttktwp egg | maternal effect (with Df(3R)awd-KRB) ttktwp egg | maternal effect (with ttk1e11) ttktwp egg | maternal effect (with ttktwp) ttk1e11 egg chamber | maternal effect ttktwp egg chamber | maternal effect (with Df(3R)awd-KRB) ttktwp egg chamber | maternal effect (with ttk1e11) ttktwp egg chamber | maternal effect (with ttktwp) ttk1e11 embryonic/first instar larval cuticle ttkdsRNA.cKa embryonic/larval cuticle ttkD2-50 embryonic/larval dorsal branch ttkD2-50 embryonic/larval dorsal trunk ttkD2-50 embryonic/larval dorsal trunk, with Scer\GAL4btl.PS ttkp69.Scer\UAS ttkGS346 embryonic/larval glial cell | supernumerary ttk1e11 embryonic/larval lateral trunk ttkD2-50 embryonic/larval visceral branch ttkD2-50 embryonic epidermis ttkunspecified embryonic head ttkdsRNA.cKa equatorial cone cell, with Scer\GAL4hs.2sev ttkp88.Scer\UAS exit glial cell ttkD2-50 extended germ band embryo | heat sensitive ttk69.hs external sensory organ ttk1 external sensory organ | adult stage | somatic clone ttkosn external sensory organ | embryonic stage | heat sensitive ttk69.hs external sensory organ | heat sensitive ttk69.hs external sensory organ precursor cell IIa ttkosn external sensory organ precursor cell IIb | supernumerary ttkosn eye ttk88.GMR.T:Hsap\MYC ttk88.hs.sev.T:Hsap\MYC ttkGMR.PX ttkrM730 eye, with Scer\GAL4ey.PB ttkp69.Scer\UAS eye, with Scer\GAL4ey.PH ttk69.PPDLS.AAAAS.Scer\UAS.T:Ivir\HA1 ttk69.Scer\UAS.T:Ivir\HA1 eye, with Scer\GAL4GMR.PF ttkp69.Scer\UAS ttkp88.Scer\UAS eye, with Scer\GAL4hs.2sev ttk69.Scer\UAS.T:Ivir\HA1 ttkp88.Scer\UAS eye, with Scer\GAL4lz-gal4 ttkp69.Scer\UAS eye | somatic clone ttk1e11 ttkrM730 eye-antennal disc ttk88.GMR.T:Hsap\MYC eye disc, with Scer\GAL4GMR.PF ttk69.Scer\UAS eye disc, with Scer\GAL4hs.2sev ttk69.ΔN153.Scer\UAS eye photoreceptor cell ttk00219 ttk88.GMR.T:Hsap\MYC ttk88.hs.sev.T:Hsap\MYC eye photoreceptor cell, with Scer\GAL4GMR.PF ttkp69.Scer\UAS ttkp88.Scer\UAS eye photoreceptor cell, with Scer\GAL4hs.2sev ttk69.PPDLS.AAAAS.Scer\UAS.T:Ivir\HA1 ttk69.Scer\UAS.T:Ivir\HA1 ttkp88.Scer\UAS eye photoreceptor cell | somatic clone ttk1e11 ttkrM730 filzkorper ttk1e11 follicle cell | maternal effect ttktwp follicle cell | maternal effect (with Df(3R)awd-KRB) ttktwp follicle cell | maternal effect (with ttk1e11) ttktwp follicle cell | maternal effect (with ttktwp) ttk1e11 follicle cell | somatic clone ttk1e11 interface glial cell, with Scer\GAL4Kr.PM ttk69.Scer\UAS interface glial cell, with Scer\GAL4MZ1580 ttk69.Scer\UAS interface glial cell, with Scer\GAL4sca-537.4 ttk69.Scer\UAS interommatidial bristle, with Scer\GAL4GMR.PF ttkp69.Scer\UAS ttkp88.Scer\UAS interommatidial bristle, with Scer\GAL4hs.2sev ttk69.ΔN153.Scer\UAS ttk69.Scer\UAS.T:Ivir\HA1 interommatidial bristle | somatic clone ttk1e11 ttkrM730 intersegmental nerve, with Scer\GAL4elav-C155 ttk69.Scer\UAS Kenyon cell, with Scer\GAL47B ttkUY181 ttkUY2545 ttkUY4606 Kenyon cell, with Scer\GAL4c739 ttkUY181 ttkp69.Scer\UAS Kenyon cell | somatic clone ttk804 lamina anlage glial cell, with Scer\GAL4c527 ttkp69.Scer\UAS lamina neuropil, with Scer\GAL4c527 ttkp69.Scer\UAS lch5 neuron | supernumerary ttkrM730 lens | somatic clone ttk1e11 ttkrM730 longitudinal connective ttkD2-50 longitudinal connective, with Scer\GAL4elav-C155 ttk69.Scer\UAS macrochaeta ttk02667 ttkBG01491 ttkhs.PB macrochaeta & leg ttkhs.PB mechanosensory ventral triple row bristle, with Scer\GAL4Bx-MS1096 ttk69.ΔBTB.Scer\UAS ttk69.ΔSA.Scer\UAS ttk69.286-ZFS.Scer\UAS ttk69.BTB-R113.Scer\UAS ttk69.BTB-ZF.Scer\UAS ttk69.BTB-ZFS.Scer\UAS ttk69.K46E.Scer\UAS ttk69.R113.Scer\UAS ttk69.S35A.Scer\UAS ttkp88.Scer\UAS medial triple row, with Scer\GAL4Bx-MS1096 ttk69.Scer\UAS ttkp88.Scer\UAS microchaeta ttk02667 ttkhs.PB microchaeta, with Scer\GAL4Eq1 ttkp69.Scer\UAS midline glial cell ttkB330 mitotic cell cycle, with Scer\GAL4GMR.PF ttk69.Scer\UAS morphogenetic furrow, with Scer\GAL4dpp.blk1 ttkp69.Scer\UAS mouth hooks ttk1e11 multidendritic neuron | heat sensitive ttk69.hs mushroom body, with Scer\GAL47B ttkUY181 ttkUY2545 ttkUY4606 mushroom body, with Scer\GAL4c739 ttkUY181 ttkp69.Scer\UAS neuron | embryonic stage ttkS003717 ttkS025025 ttkS043831 ttkS070207 ttkS104907 ttkS111904 ttkS118416 ttkS120905 ttkS120910 ttkS126010 ttkS128104 ttkS132515 ttkS137208a ttkS139614b ttkS141806a ttkS141811 ttkS142402 ttkS144802c ommatidial precursor cluster | somatic clone ttk1e11 ttkrM730 ommatidium ttk88.GMR.T:Hsap\MYC ommatidium, with Scer\GAL4hs.2sev ttk69.PPDLS.AAAAS.Scer\UAS.T:Ivir\HA1 ttk69.Scer\UAS.T:Ivir\HA1 ttkp88.Scer\UAS ommatidium, with Scer\GAL4lz-gal4 ttkp69.Scer\UAS ommatidium | somatic clone ttk1e11 ttkrM730 ommatidium | third instar larval stage, with Scer\GAL4GMR.PF ttkp69.Scer\UAS oocyte | germline clone | oogenesis stage S14 ttktwp oocyte | oogenesis stage S10B | somatic clone ttk1e11 oocyte | oogenesis stage S10B | somatic clone, with Scer\GAL4e22c ttkp69.Scer\UAS oocyte | oogenesis stage S12 | somatic clone ttktwp oocyte | oogenesis stage S13 | somatic clone ttk1e11 ttktwp oocyte | oogenesis stage S14 | somatic clone ttktwp peripheral nervous system, with Scer\GAL4Kr.PM ttkp69.Scer\UAS ttkp88.Scer\UAS photoreceptor cell ttk88.GMR.T:Hsap\MYC photoreceptor cell R1 | third instar larval stage, with Scer\GAL4GMR.PF ttkp69.Scer\UAS photoreceptor cell R1 | third instar larval stage, with Scer\GAL4lz-gal4 ttkp69.Scer\UAS photoreceptor cell R3, with Scer\GAL4hs.2sev ttkp88.Scer\UAS photoreceptor cell R3 | supernumerary, with Scer\GAL4hs.2sev ttk69.ΔN153.Scer\UAS photoreceptor cell R4, with Scer\GAL4hs.2sev ttk69.ΔN153.Scer\UAS ttkp88.Scer\UAS photoreceptor cell R6 | third instar larval stage, with Scer\GAL4GMR.PF ttkp69.Scer\UAS photoreceptor cell R6 | third instar larval stage, with Scer\GAL4lz-gal4 ttkp69.Scer\UAS photoreceptor cell R7 ttk00219 ttk1 ttk1e11 ttkbose1 ttkbose45 photoreceptor cell R7, with Scer\GAL4hs.2sev ttk69.ΔC500.Scer\UAS ttk69.ΔN153.Scer\UAS ttk69.PPDLS.AAAAS.Scer\UAS.T:Ivir\HA1 ttk69.Scer\UAS.T:Ivir\HA1 ttkp88.Scer\UAS photoreceptor cell R7 | somatic clone | supernumerary | third instar larval stage ttk1e11 ttkrM730 photoreceptor cell R7 | supernumerary, with Scer\GAL4hs.2sev ttk69.ΔN153.Scer\UAS photoreceptor cell R7 | third instar larval stage, with Scer\GAL4GMR.PF ttkp69.Scer\UAS photoreceptor cell R7 | third instar larval stage, with Scer\GAL4lz-gal4 ttkp69.Scer\UAS polar cone cell, with Scer\GAL4hs.2sev ttkp88.Scer\UAS presumptive embryonic/larval central nervous system ttk2D-50 ttkunspecified presumptive embryonic/larval central nervous system, with Scer\GAL4elav-C155 ttk69.Scer\UAS presumptive embryonic/larval peripheral nervous system ttkdsRNA.cKa ttkosn ttkunspecified presumptive embryonic/larval tracheal system ttk1e11 ttkD2-50 procuticle ttkD2-50 rhabdomere | somatic clone ttk1e11 ttkrM730 rhabdomere R1 ttk1 rhabdomere R2 ttk1 rhabdomere R3 ttk1 rhabdomere R4 ttk1 rhabdomere R5 ttk1 rhabdomere R6 ttk1 rhabdomere R7 ttk1 rhabdomere R8 ttk1 scolopale | embryonic stage ttkS070207 scolopidial dendritic cap cell | embryonic stage ttkosn scolopidial neuron | embryonic stage | heat sensitive ttk69.hs sensory mother cell & dorsal mesothoracic disc, with Scer\GAL4Bx-MS1096 ttk69.Scer\UAS sensory neuron | embryonic stage ttkunspecified sensory neuron | supernumerary ttkosn socket | adult stage | somatic clone ttkosn subretinal glial cell, with Scer\GAL4c527 ttkp69.Scer\UAS taenidial fold ttkD2-50 taenidium ttkD2-50 thecogen cell ttk1e11 thecogen cell & peripheral nervous system ttkB330 ttkE389 thecogen cell | embryonic stage ttkosn tormogen cell, with Scer\GAL4pnr-MD237 ttkGD4414 tormogen cell | somatic clone ttkosn trichogen cell | somatic clone ttkosn trichogen cell | supernumerary ttk1 ventral nerve cord primordium, with Scer\GAL4Kr.PM ttk69.Scer\UAS ventral triple row, with Scer\GAL4Bx-MS1096 ttk69.Scer\UAS wing, with Scer\GAL4Bx-MS1096 ttk69.ΔSA.Scer\UAS ttk69.286-ZFS.Scer\UAS ttk69.BTB-R113.Scer\UAS ttk69.Scer\UAS
Classical Alleles ( 104 )
For All Classical Alleles Show
Allele of ttk Class Mutagen Stocks Known lesion ttk1e11 loss of function allele, amorphic allele - genetic evidence, hypomorphic allele - genetic evidence Js P-element activity 2 Yes ttk1 loss of function allele, gain of function allele PM hybrid dysgenesis 2 Yes ttkKG01234 2 -- ttk02667 P-element activity 1 -- ttk5-HA-2917 1 -- ttk5-HA-3085 1 -- ttkc00547 piggyBac transposase 1 -- ttkc00667 piggyBac transposase 1 -- ttkc00997 piggyBac transposase 1 -- ttkc01447 piggyBac transposase 1 -- ttkc01499 piggyBac transposase 1 -- ttkc06276 1 -- ttkCB-0307-3 1 -- ttkCB-5560-3 1 -- ttkd02388 P-element activity 1 -- ttkd02455 P-element activity 1 -- ttkd03809 P-element activity 1 -- ttkd03859 P-element activity 1 -- ttkd07692 P-element activity 1 -- ttkDG02104 P-element activity 1 -- ttke00045 piggyBac transposase 1 -- ttke03721 piggyBac transposase 1 -- ttkE389 loss of function allele ethyl methanesulfonate 1 -- ttkf00319 piggyBac transposase 1 -- ttkf03798 piggyBac transposase 1 -- ttkf05207 piggyBac transposase 1 -- ttkGS3069 Delta2-3 1 Yes ttkMI00087 1 -- ttkMI01174 1 -- ttkMI03530 1 -- ttkNP3281 1 -- ttkNP4413 1 -- ttkNP5447 1 -- ttkNP5949 1 -- ttkUM-8152-3 1 -- ttkUM-8313-3 1 -- ttkUY181 P-element activity 1 Yes ttkD2-50 amorphic allele - genetic evidence ethyl methanesulfonate 0 -- ttk00219 P-element activity 0 Yes ttk01316 P-element activity 0 -- ttk03540 P-element activity 0 Yes ttk03A loss of function allele 0 -- ttk05125 P-element activity 0 -- ttk05311 P-element activity 0 -- ttk05420 P-element activity 0 -- ttk10556 hypomorphic allele - genetic evidence P-element activity 0 -- ttk150 piggyBac transposase 0 Yes ttk190.1 ethyl methanesulfonate 0 -- ttk29 0 -- ttk2D-50 ethyl methanesulfonate 0 -- ttk5346 hypomorphic allele - genetic evidence P-element activity 0 -- ttk55.3 ethyl methanesulfonate 0 -- ttk804 P-element activity 0 -- ttkB330 loss of function allele, hypomorphic allele - genetic evidence ethyl methanesulfonate 0 -- ttkBG01491 P-element activity 0 Yes ttkbose1 hypomorphic allele - genetic evidence P-element activity 0 -- ttkbose45 P-element activity 0 Yes ttkCB-0308-3 0 -- ttkCB-6356-3 0 -- ttkCB02274 P-element activity 0 Yes ttkd06985 P-element activity 0 -- ttkd07070 P-element activity 0 -- ttkd09308 P-element activity 0 -- ttke03198 0 -- ttke03722 piggyBac transposase 0 -- ttke11 0 -- ttkEP3062 P-element activity 0 -- ttkEP3228 0 -- ttkEP3314 0 -- ttkEP621 P-element activity 0 -- ttkex14b 0 -- ttkGS3026 Delta2-3 0 Yes ttkGS3165 Delta2-3 0 Yes ttkGS346 0 Yes ttkj2A1 P-element activity 0 -- ttkj6C7 P-element activity 0 -- ttkj7B8 P-element activity 0 -- ttkM50 P-element activity 0 -- ttkosn hypomorphic allele - genetic evidence P-element activity 0 -- ttkR2 Delta2-3 0 Yes ttkrM730 hypomorphic allele - genetic evidence P-element activity 0 Yes ttkS003717 Delta2-3 P-element activity 0 -- ttkS025025 Delta2-3 P-element activity 0 -- ttkS043831 Delta2-3 P-element activity 0 -- ttkS070207 Delta2-3 P-element activity 0 -- ttkS104907 Delta2-3 P-element activity 0 -- ttkS111904 Delta2-3 P-element activity 0 -- ttkS118416 Delta2-3 P-element activity 0 -- ttkS120905 Delta2-3 P-element activity 0 -- ttkS120910 Delta2-3 P-element activity 0 -- ttkS126010 Delta2-3 P-element activity 0 -- ttkS128104 Delta2-3 P-element activity 0 -- ttkS132515 Delta2-3 P-element activity 0 -- ttkS137208a P-element activity 0 -- ttkS139614b Delta2-3 P-element activity 0 -- ttkS141806a Delta2-3 P-element activity 0 -- ttkS141811 P-element activity 0 -- ttkS142402 P-element activity 0 -- ttkS144802c Delta2-3 P-element activity 0 -- ttktwp P-element activity 0 Yes ttkunspecified 0 -- ttkUY2545 P-element activity 0 Yes ttkUY4606 P-element activity 0 Yes ttkΔ2 0 --
Alleles Carried on Transgenic Constructs ( 53 )
For All Alleles Carried on Transgenic Constructs Show
Allele of ttk Class Mutagen Stocks Known lesion ttk69.cBa.Scer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 1 Yes ttk69.K317R.cBa.Scer\UAS.T:Ivir\HA1 in vitro construct - amino acid replacement 1 Yes ttk88.GMR.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 1 Yes ttk88.hs.sev.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 1 Yes ttkGD4414 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ttkJF02088 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ttkKK110420 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ttkp69.Scer\UAS in vitro construct - regulatory fusion 1 Yes ttkp88.Scer\UAS in vitro construct - regulatory fusion 1 Yes ttk69.286-ZFS.Scer\UAS in vitro construct - deletion 0 Yes ttk69.Act5C in vitro construct - regulatory fusion 0 Yes ttk69.BTB-R113.Scer\UAS in vitro construct - deletion 0 Yes ttk69.BTB-ZF.Scer\UAS in vitro construct - deletion 0 Yes ttk69.BTB-ZFS.Scer\UAS in vitro construct - deletion 0 Yes ttk69.BTB.Scer\UAS in vitro construct - deletion 0 Yes ttk69.D32A.B.Scer\UAS in vitro construct - site directed mutagenesis 0 Yes ttk69.D32A.Scer\UAS in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes ttk69.D32N.Scer\UAS in vitro construct - site directed mutagenesis 0 Yes ttk69.H45A.Scer\UAS in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes ttk69.hs in vitro construct - regulatory fusion 0 Yes ttk69.K46E.Scer\UAS in vitro construct - site directed mutagenesis 0 Yes ttk69.L49A.Scer\UAS in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes ttk69.POZ.Act5C in vitro construct - regulatory fusion 0 Yes ttk69.PPDLS.AAAAS.Scer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - amino acid replacement in vitro construct - coding region fusion 0 Yes ttk69.R113.Scer\UAS in vitro construct - deletion 0 Yes ttk69.S35A.Scer\UAS in vitro construct - site directed mutagenesis 0 Yes ttk69.Scer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes ttk69.Scer\UAS in vitro construct - regulatory fusion 0 Yes ttk69.Δ580.Act5C in vitro construct - regulatory fusion 0 Yes ttk69.ΔBTB.Scer\UAS in vitro construct - deletion 0 Yes ttk69.ΔC500.Scer\UAS in vitro construct - regulatory fusion 0 Yes ttk69.ΔC568.Scer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes ttk69.ΔN153.Scer\UAS in vitro construct - regulatory fusion 0 Yes ttk69.ΔN153PPDLS.AAAAS.Scer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - amino acid replacement in vitro construct - coding region fusion 0 Yes ttk69.ΔN153ΔC568.Scer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes ttk69.ΔN190.Scer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes ttk69.ΔN286.Scer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes ttk69.ΔN496.Scer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes ttk69.ΔN51.Scer\UAS in vitro construct - regulatory fusion 0 Yes ttk69.ΔSA.Scer\UAS in vitro construct - deletion 0 Yes ttk88.hs in vitro construct - regulatory fusion 0 Yes ttk88.Hsp70Bb.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes ttk88.MtnA.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes ttk88.MtnA:T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes ttk88.T:Ecol\lexA in vitro construct - coding region fusion 0 Yes ttkdsRNA.cIa in vitro construct - RNAi 0 Yes ttkdsRNA.cKa in vitro construct - RNAi 0 Yes ttkfl.cGa in vitro construct 0 Yes ttkGMR.PX in vitro construct - regulatory fusion 0 Yes ttkhs.PB in vitro construct - regulatory fusion 0 Yes ttkhs.PP in vitro construct - regulatory fusion 0 Yes ttkMtnA.PL in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes ttkΔPOZ.Act5C in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)04661 (Spradling et al., 1999, BDGP Project Members, 1994-1999) Df(3R)awd-KRB (Szeged Stock Center, 1998-, Spradling et al., 1999, French et al., 2003, Cook, 2006.1.31, Xiong and Montell, 1993, BDGP Project Members, 1994-1999, Salzberg et al., 1994, Giesen et al., 1997) Df(3R)B81 (BDGP Project Members, 1994-1999) Df(3R)BSC505 (Christensen et al., 2008.4.15) Df(3R)Exel6220 (Ryder, 2004.4.26) Df(3R)Kpn-rev7 (Guo et al., 1995) Df(3R)ttk-Δ1 (Wisotzkey et al., 1998) Df(3R)ttk-Δ2 (Wisotzkey et al., 1998) Df(3R)ttk-Δ3 (Wisotzkey et al., 1998) Df(3R)ttk-Δ4 (Lai et al., 1996, Lai et al., 1997) T(Y;3)B81 (BDGP Project Members, 1994-1999) T(Y;3)R133 (BDGP Project Members, 1994-1999)
Not disrupted in	Df(3R)B81 (Szeged Stock Center, 1998-) Df(3R)E(sina)9 (Wisotzkey et al., 1998) Df(3R)faf-BP (Szeged Stock Center, 1998-) Df(3R)p712 (BDGP Project Members, 1994-1999) Df(3R)tll-e (Spradling et al., 1999, Cook, 2006.1.31, BDGP Project Members, 1994-1999) Df(3R)tll-g (Cook, 2006.1.31)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data heat-shock construct P{hs69-2} NA P{hs69-ttk} NA P{hs88} NA P{hs-ttk.B} NA P{sev-ttk88} NA UAS construct P{GD4414} NA P{KK110420} NA P{TRiP.JF02088} NA P{UAS-ttk.69.286-ZFS} NA P{UAS-ttk.69.B} NA P{UAS-ttk.69.BTB} NA P{UAS-ttk.69.BTB-R113} NA P{UAS-ttk.69.BTB-ZF} NA P{UAS-ttk.69.BTB-ZFS} NA P{UAS-ttk.69.D32A.B} NA P{UAS-ttk.69.D32A} NA P{UAS-ttk.69.D32N} NA P{UAS-ttk.69.H45A} NA P{UAS-ttk.69.HA} NA P{UAS-ttk.69.K46E} NA P{UAS-ttk.69.K317R.HA} NA P{UAS-ttk.69.L49A} NA P{UAS-ttk.69.PPDLS/AAAAS} NA P{UAS-ttk.69.R113} NA P{UAS-ttk.69.S35A} NA P{UAS-ttk.69.ΔBTB} NA P{UAS-ttk.69.ΔC500} NA P{UAS-ttk.69.ΔC568} NA P{UAS-ttk.69.ΔN51} NA P{UAS-ttk.69.ΔN153} NA P{UAS-ttk.69.ΔN153PPDLS/AAAAS} NA P{UAS-ttk.69.ΔN153ΔC568} NA P{UAS-ttk.69.ΔN190} NA P{UAS-ttk.69.ΔN286} NA P{UAS-ttk.69.ΔN496} NA P{UAS-ttk.69.ΔSA} NA P{UAS-ttk.69} NA P{UAS-ttk.p69} NA P{UAS-ttk.p88} NA characterization construct P{GMR-ttk88} NA P{GMR-ttk.X} NA P{UAS-ttk.69.Bcl6ΔN153} NA P{UAS-ttk.69.GAGAΔN116} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}ttkEP621 NA P{EP}ttkEP3062 NA P{EP}ttkEP3228 NA P{EP}ttkEP3314 NA P{GSV1}GSd034GSd034 NA P{GSV1}GSd446GSd446 NA P{GSV1}GSd462a NA P{GSV1}GSd468GSd468 NA P{GSV1}ttkGS346 NA P{GSV1}ttkGS3026 NA P{GSV1}ttkGS3069 NA P{GSV1}ttkGS3165 NA P{Mae-UAS.6.11}B0674B0674 NA P{Mae-UAS.6.11}B1522B1522 NA P{Mae-UAS.6.11}ttkUY181 NA P{Mae-UAS.6.11}ttkUY2545 NA P{Mae-UAS.6.11}ttkUY4606 NA P{XP}ttkd02388 NA P{XP}ttkd02455 NA P{XP}ttkd03809 NA P{XP}ttkd03859 NA P{XP}ttkd06985 NA P{XP}ttkd07070 NA P{XP}ttkd07692 NA P{XP}ttkd09308 NA insertion of enhancer trap P{lacW}S139614 No P{lacW}ttkj2A1 No P{lacW}ttkj6C7 No P{lacW}ttkj7B8 No P{lacW}ttkM50 No P{lacW}ttkosn No P{lacW}ttkS003717 No P{lacW}ttkS025025 No P{lacW}ttkS043831 No P{lacW}ttkS070207 No P{lacW}ttkS104907 No P{lacW}ttkS111904 No P{lacW}ttkS118416 No P{lacW}ttkS120905 No P{lacW}ttkS120910 No P{lacW}ttkS126010 No P{lacW}ttkS128104 No P{lacW}ttkS132515 No P{lacW}ttkS137208a No P{lacW}ttkS141806a No P{lacW}ttkS141811 No P{lacW}ttkS142402 No P{lacW}ttkS144802c No P{lacZ}ttkrM730 No P{lwB}ttkbose1 No P{PZ}ttk1 No P{PZ}ttk00219 No P{PZ}ttk01316 No P{PZ}ttk02667 No P{PZ}ttk03540 No P{PZ}ttk05125 No P{PZ}ttk05311 No P{PZ}ttk5346 No P{PZ}ttk05420 No P{PZ}ttk10556 No P{PZ}ttktwp No miscellaneous insertions Mi{MIC}ttkMI00087 NA Mi{MIC}ttkMI01174 NA Mi{MIC}ttkMI03530 NA P{804}ttk804 NA P{GT1}ttkBG01491 NA P{PT1}ttk29 NA P{PTT-GB}ttkCB02274 NA P{RS3}ttkCB-0307-3 NA P{RS3}ttkCB-0308-3 NA P{RS3}ttkCB-5560-3 NA P{RS3}ttkCB-6356-3 NA P{RS3}ttkUM-8152-3 NA P{RS3}ttkUM-8313-3 NA P{RS5}ttk5-HA-2917 NA P{RS5}ttk5-HA-3085 NA P{SUPor-P}ttkKG01234 NA P{wHy}ttkDG02104 NA PBac{PB}ttkc00547 NA PBac{PB}ttkc00667 NA PBac{PB}ttkc00997 NA PBac{PB}ttkc01447 NA PBac{PB}ttkc01499 NA PBac{PB}ttkc06276 NA PBac{RB}ttke00045 NA PBac{RB}ttke03198 NA PBac{RB}ttke03721 NA PBac{RB}ttke03722 NA PBac{WH}ttkf00319 NA PBac{WH}ttkf03798 NA PBac{WH}ttkf05207 NA insertion of enhancer trap binary system P{GawB}ttkNP3281 No P{GawB}ttkNP4413 No P{GawB}ttkNP5447 No P{GawB}ttkNP5949 No PBac{GAL4D,EYFP}ttk150 No
Gene Ontology: Function, Process & Cellular Component ( 37 unique terms )
Terms Based on Experimental Evidence ( 31 terms )
Molecular Function
CV term Evidence References
chromatin binding inferred from direct assay (Dallman et al., 2004) protein binding inferred from physical interaction with CoRest (Dallman et al., 2004) inferred from physical interaction with UniProtKB:Q08605 (assigned by UniProtKB) (Pagans et al., 2002) protein homodimerization activity inferred from physical interaction with UniProtKB:P17789 (assigned by UniProtKB) (Pagans et al., 2002) RNA polymerase II core promoter proximal region sequence-specific DNA binding inferred from direct assay (Read and Manley, 1992) RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription inferred from direct assay (Dallman et al., 2004) RNA polymerase II distal enhancer sequence-specific DNA binding inferred from direct assay (Yu et al., 1999)
Biological Process
CV term Evidence References
brain morphogenesis inferred from mutant phenotype (Yamamoto et al., 2008) branch fusion, open tracheal system inferred from mutant phenotype (Araujo et al., 2007) branching involved in open tracheal system development inferred from mutant phenotype (Araujo et al., 2007) chitin-based cuticle development inferred from mutant phenotype (Araujo et al., 2007) compound eye cone cell differentiation inferred from mutant phenotype (Siddall et al., 2009) compound eye corneal lens morphogenesis inferred from mutant phenotype (Siddall et al., 2009) dendrite morphogenesis inferred from mutant phenotype (Parrish et al., 2006) dorsal appendage formation inferred from mutant phenotype (French et al., 2003, Boyle and Berg, 2009) dorsal trunk growth, open tracheal system inferred from mutant phenotype (Araujo et al., 2007) inter-male aggressive behavior inferred from mutant phenotype (Edwards et al., 2009) locomotion involved in locomotory behavior inferred from mutant phenotype (Yamamoto et al., 2008) negative regulation of transcription, DNA-dependent inferred from direct assay (Dallman et al., 2004) neuron development inferred from mutant phenotype (Parrish et al., 2006) ovarian follicle cell development inferred from mutant phenotype (Jordan et al., 2006) positive regulation of transcription from RNA polymerase II promoter inferred from direct assay (Yu et al., 1999) R1/R6 development inferred from mutant phenotype (Siddall et al., 2009) R7 cell development inferred from mutant phenotype (Siddall et al., 2009) regulation of cell shape inferred from mutant phenotype (Boyle and Berg, 2009) regulation of embryonic cell shape inferred from mutant phenotype (Araujo et al., 2007) regulation of tube size, open tracheal system inferred from mutant phenotype (Araujo et al., 2007) startle response inferred from mutant phenotype (Yamamoto et al., 2008) tracheal outgrowth, open tracheal system inferred from mutant phenotype (Araujo et al., 2007)
Cellular Component
CV term Evidence References
nucleus inferred from direct assay (Read and Manley, 1992, Dallman et al., 2004) polytene chromosome inferred from direct assay (Murawsky et al., 2001, Reddy et al., 2010) transcriptional repressor complex inferred from physical interaction with CoRest (Dallman et al., 2004)
Terms Based on Predictions or Assertions ( 8 terms )
Molecular Function
CV term Evidence References
sequence-specific DNA binding transcription factor activity non-traceable author statement (FlyBase, 1992-) zinc ion binding inferred from electronic annotation with InterPro:IPR007087, InterPro:IPR015880 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
cell fate determination traceable author statement (Bardin et al., 2004) negative regulation of transcription from RNA polymerase II promoter non-traceable author statement (Swiss-Prot Project Members, 1990.8.1, Swiss-Prot Project Members, 1995.6.1) peripheral nervous system development traceable author statement (Salzberg et al., 1994) R7 cell development traceable author statement (Kumar and Moses, 2000) regulation of transcription from RNA polymerase II promoter non-traceable author statement (FlyBase, 1992-)
Cellular Component
CV term Evidence References
nucleus non-traceable author statement (FlyBase, 1992-, Swiss-Prot Project Members, 1990.8.1, Swiss-Prot Project Members, 1995.6.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions ttk allele Gene References ttk1 phyl (Tang et al., 1997) run (Wheeler et al., 2002) sev (Dong et al., 1999) ttk1e11 run (Wheeler et al., 2002) ttk55.3 aop (Lai et al., 1997) ttk69.hs ac (Badenhorst et al., 2002) ttk69.Scer\UAS.T:Ivir\HA1 CtBP (Wen et al., 2000) ttk69.Scer\UAS stg (Baonza et al., 2002) ttk88.GMR.T:Hsap\MYC phyl (Tang et al., 1997) ttk88.hs.sev.T:Hsap\MYC phyl (Tang et al., 1997) ttk190.1 ksr (Lai et al., 1997) ttk00219 ac (Badenhorst et al., 2002) aop (Lai et al., 1996) h (Badenhorst et al., 2002) Ras85D (Lai et al., 1996) sev (Dong et al., 1999) ttk5346 run (Wheeler et al., 2002) ttk10556 run (Wheeler et al., 2002) ttkbose1 aop (Yamamoto et al., 1996) ttkbose45 aop (Yamamoto et al., 1996) ttkosn msi (Okabe et al., 2001) sina (Hirota et al., 1999) ttkp69.Scer\UAS repo (Yuasa et al., 2003) ttkrM730 ac (Badenhorst et al., 2002) aop (Lai et al., 1996) CtBP (Badenhorst et al., 2002) emc (Badenhorst et al., 2002) h (Badenhorst et al., 2002) Mi-2 (Murawsky et al., 2001) Ras85D (Lai et al., 1996) Rpd3 (Murawsky et al., 2001) ttkS070207 bft (Hardiman et al., 2002) unspecified CycE (Audibert et al., 2005) ebi (Dong et al., 1999) msi (Hirota et al., 1999) pbl (Gregory et al., 2007) run (Wheeler et al., 2002) sc (Badenhorst et al., 2002)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 71315 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0003870 DroID - A comprehensive database of gene and protein interactions. • FBgn0003870 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 48317
Orthologs
Genome-wide drosophilid orthologs	Dana\GF22979 Dere\GG11824 Dgri\GH18647 Dmoj\GI23126 Dper\GL23993 Dpse\ttk Dsec\GM16442 Dsim\ttk Dvir\GJ23100 Dwil\GK12114 Dyak\ttk
Curated drosophilid orthologs	Dpse\ttk   Dsil\ttk
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AGAP003537-PA Anopheles gambiae (mosquito) XP_394394.3 Apis mellifera (honey bee) XP_001951822.1 Acyrthosiphon pisum (pea aphid) 90539 Branchiostoma floridae (lancelet) BGIBMGA007530-PA Bombyx mori (silk worm) PHUM010213-PA Pediculus humanus (human body louse) XP_971671.2 Tribolium castaneum (red flour beetle) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB11637 PB11625 NV30328 NV13850 LH21665 LH21661 ISCW016363 ISCW016355 FBgn0228787 FBgn0214125 FBgn0210203 FBgn0193021 FBgn0171358 JGI_V11_8020 FBgn0075017 FBgn0161583 FBgn0145854 FBgn0126115 FBgn0104119 FBgn0099974 CPIJ009648 CPIJ009646 BGIBMGA007531 BGIBMGA007530 ACYPI002482 GB10751 AGAP003537 AAEL003947 PHUM489940 GLEAN_13842 GLEAN_13843
Stocks & Reagents
Stocks Listed in FlyBase ( 49 )
Bloomington	5776 P{sev-ttk88}AT1
Harvard	- P{XP}ttkd02388 - P{XP}ttkd02455 - P{XP}ttkd03809 - P{XP}ttkd03859 - P{XP}ttkd07692 - PBac{PB}ttkc00547 - PBac{PB}ttkc00667 - PBac{PB}ttkc00997 - PBac{PB}ttkc01447 - PBac{PB}ttkc01499
VDRC	v101980 P{KK110420}VIE-260B
	More stocks available...
Genomic Clones ( 2 )
	BACR16C04 BACR48C22 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 190 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GM09101 IP15250 LD28689 RE06404 RE69322
Other clones	DPiM_LD28689
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT13118 GH14220 GM02721 GM07569 LD09488 LD11248 LD16437 LP01124 LP03742 LP21039 RE02667 RE04551 RE08518 RE11718 RE12984 RE25096 RE26557 RE26560 RE27487 RE30883 RE34551 RE34788 RE34888 RE42166 RE43431 RE43443 RE46018 RE46844 RE47263 RE51602 RE58367 RE61256 RE61603 RE63252 RE64537 RE64785 RE66888 RE67795 RE70817 RH23347 SD04524 SD05556
Other clones	5385 10563 10811 11049 16846 17372 34311 38317 39084 39697 43728 45104 51472 60876 62280 72007 72073 72490 74054 74364 75156 75177 78467 82903 103746 105778 107838 108534 108812 120736 121949 156401 156774 160834 160850 162122 167161 173146 174269 179643 184038 214217.32 214251.23 214319.32 214411.30 214479.31 273427 273767 274868 274937 AI124297 AT21526 CK01.8A.H12 CK01.19B.H6 CK01.32C.G3 CK01.37A.D3 CK01.44C.D4 CK01.50C.G3 CK01.52B.D8 CK01.65C.F12 CK01.90C.H11 CK01.107D.A6 CK01.133B.G4 CK01.142C.D12 CK01.143A.G6 CK01.167C.A4 CK01338 Dmel_neb_016204_0935_1565 EC051006 EK018163 EK037246 EK040526 EK042348 EK053256 EK055003 EK060103 EK071032 EK081835 EK101958 EK103034 EK110611 EK111225 EK111509 EK115946 EK116159 EK124422 EK129643 EK149132 EK152042 EK153220 EK158925 EK160652 EK162426 EK163317 EK175804 EK178106 EK184409 EK186860 EK189056 EK196611 EK200642 EK200962 EK206049 EK207118 EK207609 EK207916 EK222905 EK226622 EK230950 EK234232 EK234940 EK235157 EK240729 EK242148 EK244741 EK259326 EK260064 EK264540 EK265912 EK272126 EK273348 EK288758 EK300543 EK302555 EK302850 EK307503 EP00921 EP09814 EP10248 EP10759 EP11047 EP11401 ESG013b.E21_E01 FGC002C09 FGH103B08 IP15350 IP15450 IP15550 LP03770 RE01180 RP004216185 RP004514845
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0003870 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 48317
Antibody Information
	polyclonal (Read and Manley, 1992, Reddy et al., 2010)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: ttk CG1856 (Bayraktaroglu, 2000.4.13) Source for merge of: ttk CG11558 (Teixeira, 2000.10.14)
Additional comments
Other Comments
	dsRNA has been made from templates generated with primers directed against this gene. RNAi of ttk results in dorsal overextension of primary dendrites and a reduction in lateral branching. RNAi also causes alterations in the number of MD neurons, defects in dendrite morphogenesis and reproducible defects in da dendrite development. (Parrish et al., 2006) ChEST reveals this is a target of Mef2. (Junion et al., 2005) ttk69 is required for dorsal appendage morphogenesis, but is not required fort cell fate determination. (French et al., 2003) The ttk69 protein isoform is a repressor of stg mRNA transcription in the eye disc. (Baonza et al., 2002) ed defines a pathway that antagonizes Egfr signalling by regulating the activity, but not the level, of the ttk TTK88 transcriptional repressor. (Bai et al., 2001) Repression of the ttk protein TTK69 in the neuronal lineage occurs translationally rather than transcriptionally. Translational repression of ttk occurs via its mRNA 3' untranslated region, by the action of msi protein. (Okabe et al., 2001) Overexpression of ttk69 protein not only blocks neuronal photoreceptor differentiation but also promotes non-neural cone cell specification in early eye development. (Wen et al., 2000) ttk is down-regulated in developing photoreceptor cells by msi and sina functioning redundantly. (Hirota et al., 1999) The ttk isoform Ttk69, plays a positive and autonomous role in promoting and maintaining differentiation of photoreceptor neurons at the late stages of Drosophila eye development. ttk appears to have a dual function by serving negative and positive regulatory roles at different stages of photoreceptor development. (Lai and Li, 1999) Identification: Enhancer trap expression pattern survey for loci expressed in the ring gland. (Harvie et al., 1998) ttk is required for proper glial cell development in the CNS. Phenotypes of doubly mutant ttk and pnt embryos and ectopic expression of ttk and pnt indicates the existance of two independent genetic pathways regulating glial cell development, which in the lateral glia are both downstream of gcm. One, mediated via pnt, results in the activation of glia cell differentiation, whereas the other, mediated by ttk, results in the suppression of neuronal differentiation in these cells. (Giesen et al., 1997) aop and ttk synergistically interact in an inhibitory signaling pathway that is critical for neural cell fate determination. (Lai et al., 1997) Mutant phenotype indicates both aop and ttk are involved in the Ras/MAPK pathway, although their mechanisms of action to inhibit to inhibit cell fate might be different. (Lai et al., 1997) aop and ttk mutations dominantly suppress eye phenotypes of ksr mutants. (Lai et al., 1997) Down-regulation of ttk protein expression occurs in photoreceptor cells and is required for their fate determination. This down-regulation requires the presence of the phyl and sina proteins. (Li et al., 1997) Expression of the ttk TTK88 protein isoform represses neuronal fate determination in the developing eye. phyl protein acts to antagonise this repression by a mechanism that requires sina protein. (Tang et al., 1997) Ubiquitous expression of ttk prevents the acquisition of both es and md neural fates, therefore ttk is not involved in the choice between es and md identities. (Vervoort et al., 1997) aop and ttk mutations both act to repress inappropriate R7 cell determination, their mechanisms of action differ. In aop mutants the presence of supernumerary R7 cells depends on sina activity. In ttk mutants supernumerary R7 cells form even when sina activity is reduced. (Lai et al., 1996) Initiation of ftz transcription is regulated by the concentration of maternally loaded ttk. Altering the dose of ttk in embryos shifts the activation of ftz transcription either forward or backward during development but does not affect Kr activation. (Pritchard and Schubiger, 1996) The role of ttk during sensory development is to impose the "non-neural" fate at each choice point during the lineage. (Dambly-Chaudiere et al., 1995) ttk has a role in the determination of different sensory organ precursor daughter cell fates. Loss of ttk function transforms support cells to neurons and overexpression results in the reverse transformation. Loss of ttk or numb function in sensory organ precursor daughter cells results in reciprocal cell fate transformation, epistatic studies suggest that ttk acts downstream of numb. (Guo et al., 1995) Removal of the POZ (poxvirus and zinc finger) domain increases DNA binding affinity of the chromosome. (Bardwell and Treisman, 1994) Mutation in ttk affects the neuronal lineage, causes transformation of support cells into neurons. (Salzberg et al., 1994) ttk is required for PNS development in the embryo. (Salzberg et al., 1994) The highly complex pattern of ttk expression suggests specific functions for ttk late in development that are separate from the regulation of ftz. Ectopic ttk expression causes complete or near complete repression of ftz and significant repression of eve, odd, h and runt. (Brown and Wu, 1993) The structure of a two zinc finger DNA-binding domain from the ttk protein complexed with DNA is reported. (Fairall et al., 1993) Biochemical studies led to the identification multiple DNA-binding proteins (including ftz-f1 and ttk) that regulate ftz gene expression through the proximal enhancer, to mediate stripe establishment and maintenance. (Han et al., 1993) The structure of the DNA binding domain in complex with a specific binding site is determined. (Schwabe et al., 1993) ttk gene product is required for cell fate determination in the compound eye. (Xiong and Montell, 1993) ttk has been cloned and sequenced. It is a zinc finger protein. (Read and Manley, 1992) Maternally supplied ttk protein helps to establish the timing of the onset of zygotic expression of eve and ftz thereby preventing premature activation. (Read et al., 1992) The ttk product binds to the zebra stripe element of the ftz promoter, behaving as a transcriptional repressor. (Brown et al., 1991) ttk protein binds to a number of sites in the transcriptional control regions of the ftz gene. (Harrison and Travers, 1990) Gene encodes a zinc-finger protein binding to a number of sites involved in the transcriptional control of fushi-tarazu in the Antennapedia complex.
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_080172 NM_170564 NM_170565 NM_170566 NM_170567 NM_170568 NM_001202400 NM_001202401 RefSeq (Proteins) • NP_524911 NP_733443 NP_733444 NP_733445 NP_733446 NP_733447 NP_001189329 NP_001189330 DDBJ / EMBL / GenBank • AA697110 AA950222 AAA28544 AAF57179 AAF57180 AAF57181 AAF57182 AAM11115 AAM52681 AAN14282 AAN14283 AAN71478 ADV37419 ADV37420 AF006649 AI124297 AQ025128 AQ034094 AQ073312 AW941964 AW942904 AY094762 AY122169 AY863929 AY863930 AY863931 AY863932 AY863933 AY863934 AY863935 AY863936 AY863937 AY863938 AY863939 AY863940 AY863941 AY863942 AY863943 AY863944 AY863945 AY863946 AY863947 AY863948 AY863949 AY863950 AY863951 BI166318 BI485958 BT001723 CAA34981 CAA50633 CAA50634 CAA77785 CAA77786 CZ466544 CZ466640 CZ466793 CZ467174 CZ467212 CZ472781 CZ472821 CZ473573 CZ473597 CZ475463 CZ475516 CZ475873 CZ476673 CZ477956 CZ481474 CZ481476 CZ482791 CZ486388 CZ487832 M62856 X17121 X71626 X71627 Z11723 Entrez Gene - A searchable database of RefSeq genes. • 48317 UniProtKB/Swiss-Prot • P17789 P42282 UniProtKB/TrEMBL • Q8T3M3
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • AT hook, DNA-binding motif (IPR017956) BTB/POZ fold (IPR011333) Zinc finger, C2H2-type/integrase, DNA-binding (IPR013087) Zinc finger, C2H2-like (IPR015880) BTB/POZ-like (IPR000210) Zinc finger, C2H2 (IPR007087) BTB/POZ (IPR013069) PDB - Protein Data Bank. An information portal to biological macromolecular structures • 2DRP
Linkouts
	BioGRID - A database of protein and genetic interactions • 71315 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0003870 DroID - A comprehensive database of gene and protein interactions. • FBgn0003870 DRSC - Results from RNAi screens. • FBgn0003870 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003870 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1856-RF;CG1856-RE FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0003870 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 48317 InParanoid A subset of ortholog calls from InParanoid. • AGAP003537-PA Anopheles gambiae (mosquito) XP_394394.3 Apis mellifera (honey bee) XP_001951822.1 Acyrthosiphon pisum (pea aphid) 90539 Branchiostoma floridae (lancelet) BGIBMGA007530-PA Bombyx mori (silk worm) PHUM010213-PA Pediculus humanus (human body louse) XP_971671.2 Tribolium castaneum (red flour beetle) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /gene/tramtrac.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 48317 modMine - Data generated by the modENCODE project. • FBgn0003870 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB11637 PB11625 NV30328 NV13850 LH21665 LH21661 ISCW016363 ISCW016355 FBgn0228787 FBgn0214125 FBgn0210203 FBgn0193021 FBgn0171358 JGI_V11_8020 FBgn0075017 FBgn0161583 FBgn0145854 FBgn0126115 FBgn0104119 FBgn0099974 CPIJ009648 CPIJ009646 BGIBMGA007531 BGIBMGA007530 ACYPI002482 GB10751 AGAP003537 AAEL003947 PHUM489940 GLEAN_13842 GLEAN_13843 REDfly - A database of transcriptional regulatory elements. • FBgn0003870
Synonyms & Secondary IDs ( 56 )
Reported As
Symbol Synonym	0037/17 (Deak et al., 1997) 0250/25 (Deak et al., 1997) 0438/31 (Deak et al., 1997) 0702/07 (Deak et al., 1997) 1049/07 (Deak et al., 1997) 1119/04 (Deak et al., 1997) 1184/16 (Deak et al., 1997) 1209/05 (Deak et al., 1997) 1209/10 (Deak et al., 1997) 1260/10 (Deak et al., 1997) 1281/04 (Deak et al., 1997) 1325/15 (Deak et al., 1997) 1372/08 (Deak et al., 1997) 1396/14 (Deak et al., 1997) 1418/06 (Deak et al., 1997) 3540 (Harvie et al., 1998) 5125 (Harvie et al., 1998) 5311 (Harvie et al., 1998) anon-EST:Liang-2.9   CG1856 (Norga et al., 2003, Teixeira, 2000.10.14, Quinones-Coello, 2007, Grieder et al., 2007, Perkins et al., 2009.3.31, Mohammad et al., 2009, Keleman et al., 2009.8.5, Rach et al., 2009, Reddy et al., 2010) CG11558 (Teixeira, 2000.10.14, ) clone 2.9 (Liang and Biggin, 1998) E(yan)100D (Kumar and Moses, 2000, Lai et al., 1996) FTZ-F2 (Kumar and Moses, 2000, Pankratz and Jaeckle, 1993, ) ftz-f2   ftzf2/ttk (Brown, 1991) l(3)02667   l(3)j2A1   l(3)j7B8   osn (Ghysen and Dambly-Chaudiere, 1993, Jan and Jan, 1990) oss (Kumar and Moses, 2000, Hardy, 1990) ovs   tramtrak (Chen et al., 2005) ttk (Althauser et al., 2005, Edwards et al., 2006, Kelly and Daniel, 2006, Xie and Birchler, 2007, Altenhein et al., 2006, Stark et al., 2005, de Velasco et al., 2006, Araújo et al., 2007, Zhang et al., 2006, Aerts et al., 2007, Song and Taylor, 2003, Buszczak et al., 2007, Quinones-Coello, 2007, Jordan et al., 2006, Letizia et al., 2007, Arancio et al., 2010, Boyle and Berg, 2008, Xie and Birchler, 2008, Chen et al., 2002, Christensen et al., 2008.4.15, Lecuyer et al., 2007, Grieder et al., 2007, Brodsky et al., 2004, Macdonald and Long, 2005, Minidorff et al., 2007, Joly et al., 2007, Minidorff et al., 2007, Wang et al., 2006, Sandmann et al., 2006, Sun and Deng, 2007, Araujo et al., 2007, Spokony and Restifo, 2007, Remaud et al., 2008, Yamamoto et al., 2008, Bassett, 2009.2.25, Liu et al., 2009, Nagaraj and Banerjee, 2009, Dworkin et al., 2009, Rach et al., 2009, Iovino et al., 2009, Bushati et al., 2008, Boyle and Berg, 2009, Mugat et al., 2008, Burgio et al., 2008, Mourikis et al., 2010, Walrad et al., 2011, Yatsu et al., 2008, The modENCODE Consortium, 2010, The modENCODE Consortium, 2010, Goto et al., 2011, Boyle et al., 2010, Cunha et al., 2010) Ttk (Junion et al., 2005, Wheeler et al., 2002, Bardwell and Treisman, 1994, Sun and Deng, 2007, Parrish et al., 2006, Li et al., 2002, Sun et al., 2008, Sun et al., 2008, Noyes et al., 2008, Andrews et al., 2009, Bauer et al., 2010) TTK (Lüer and Technau, 2009) ttk69 (Chen et al., 2005, Bardin et al., 2004, Turner and Crossley, 2001, Boyle and Berg, 2009) Ttk69 (Lehembre et al., 2000, Schweisguth, 1999, Siddall et al., 2006, Li et al., 2009, Siddall et al., 2009) TTK69 (Reddy et al., 2010) TTK88 (Bai et al., 2001, Reddy et al., 2010) Ttk88 (Dallman et al., 2004, Voas and Rebay, 2004, Li et al., 2009) ttk/FTZ-F2 (Han et al., 1993) TTKA (Mukai et al., 2007) ttkp69 (Egger et al., 2002) twk (Boyle et al., 2005)
Name Synonym	Enhancer of yan at 100D (Lai et al., 1996) oversensitive (Salzberg et al., 1993, Jan and Jan, 1993, Kumar and Moses, 2000, Ghysen and Dambly-Chaudiere, 1993, Hardy, 1990, ) schmal (Kumar and Moses, 2000, Giesen et al., 1997) tramtrack (Althauser et al., 2005, Edwards et al., 2006, Harbison and Sehgal, 2008, Montell, 1993.4.26, Montell, 1993.4.26, Robin et al., 2007, Jones et al., 2006, Boyle and Berg, 2007, Gregory et al., 2007, de Velasco et al., 2006, Nurminsky, 2007, Larsen et al., 2006, Boyle and Berg, 2008, Wang et al., 2006, Sun and Deng, 2007, Remaud et al., 2008, Yamamoto et al., 2008, Schaaf et al., 2009, Tian et al., 2009, Rach et al., 2009, Shalaby et al., 2009, Edwards et al., 2009, Mugat et al., 2008, Mummery-Widmer et al., 2009, Morozova et al., 2006, Mourikis et al., 2010, Goto et al., 2011, Boyle et al., 2010) Tramtrack (Jemc and Rebay, 2007, Araújo et al., 2007, Adryan and Teichmann, 2007, Li et al., 2002, Sun et al., 2008, Chen et al., 2002, Chia et al., 2008, Araujo et al., 2007, Sun et al., 2008, Spokony and Restifo, 2007, Nagaraj and Banerjee, 2009, Andrews et al., 2009, Lüer and Technau, 2009) tramtrack-69 (Berg, 2005) Tramtrack69 (Eastman and Eby, 2004, Boyle and Berg, 2009, Siddall et al., 2009) tramtrack69 (Dean et al., 2002, Nguyen et al., 2000) Tramtrack88 (Dallman et al., 2004) tramtrak (Burnett et al., 2006) Tramtrak (Jordan et al., 2006) Ttk88 repressor (Voas and Rebay, 2004)
Secondary FlyBase IDs
	FBgn0011319 FBgn0011402 FBgn0011681 FBgn0039865 FBgn0039866
References ( 347 )
Generate a list of	All references relating to this gene ( 347 )
List References by type	Research paper  ( 186 ) Supplementary material  ( 9 ) Review  ( 55 ) Personal communication to FlyBase  ( 20 ) Abstract  ( 58 ) FlyBase analysis  ( 3 ) Teaching note  ( 1 ) DNA/RNA sequence record  ( 3 ) Conference report  ( 1 ) Computer file  ( 5 ) Protein sequence record  ( 2 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 2 ) Book  ( 1 )
Recent research papers ( 10 )
	Carreira et al., 2011, BMC Dev. Biol. 11: 32 Genetic basis of wing morphogenesis in Drosophila: sexual dimorphism and non-allometric effects of shape variation. [FBrf0214273] Goto et al., 2011, J. Neurosci. 31(14): 5454--5459 Sexually dimorphic shaping of interneuron dendrites involves the hunchback transcription factor. [FBrf0213400] Walrad et al., 2011, Mol. Biol. Cell 22(8): 1364--1374 Hairless is a cofactor for Runt-dependent transcriptional regulation. [FBrf0213441] Xie et al., 2011, Genetics 188(4): 823--834 Inhibition of RNA interference and modulation of transposable element expression by cell death in Drosophila. [FBrf0214636] Arancio et al., 2010, Genetics 185(1): 129--140 The nucleosome remodeling factor ISWI functionally interacts with an evolutionarily conserved network of cellular factors. [FBrf0213976] Bauer et al., 2010, BMC Bioinformatics 11: 366 Dual-functioning transcription factors in the developmental gene network of Drosophila melanogaster. [FBrf0211408] Boyle et al., 2010, Dev. Biol. 346(1): 68--79 Division of labor: Subsets of dorsal-appendage-forming cells control the shape of the entire tube. [FBrf0211761] Cunha et al., 2010, PLoS Genet. 6: e1001014 Combinatorial binding leads to diverse regulatory responses: Lmd is a tissue-specific modulator of Mef2 activity. [FBrf0211225] Mourikis et al., 2010, BMC Dev. Biol. 10: 107 Modifiers of notch transcriptional activity identified by genome-wide RNAi. [FBrf0212287] Reddy et al., 2010, Mol. Cell. Biol. 30(21): 5234--5244 Drosophila Transcription Factor Tramtrack69 Binds MEP1 To Recruit the Chromatin Remodeler NuRD. [FBrf0212010] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...