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Gene Dmel\αTub84B

General Information
Symbol	Dmel\αTub84B	Species	D. melanogaster
Name	α-Tubulin at 84B	Annotation symbol	CG1913
Feature type	protein_coding_gene	FlyBase ID	FBgn0003884
Gene Model Status	Current	Stock availability	19 publicly available
Also Known As	alphaTub84B, αTUB, α-Tub, Tub, α84B, α-tubulin, Tubα1, DM1α, α1, Tuba84B
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	84B2-84B2	Sequence location	3R:2,912,260..2,914,582 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene α-Tubulin at 84B is referred to in FlyBase by the symbol Dmel\αTub84B (CG1913, FBgn0003884). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: structural constituent of cytoskeleton. There is experimental evidence that it is involved in the biological process: mitotic cell cycle spindle assembly checkpoint; cellular process; mitotic spindle organization; antimicrobial humoral response. 39 alleles are reported. The phenotypes of these alleles are annotated with: spermatid; mesothoracic tergum. It has one annotated transcript and one annotated polypeptide. Protein features are: Alpha tubulin; Tubulin; Tubulin, C-terminal; Tubulin, conserved site; Tubulin/FtsZ, 2-layer sandwich domain; Tubulin/FtsZ, C-terminal; Tubulin/FtsZ, GTPase domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely high expression to a trough of very high expression. Peak expression observed within 00-18 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period. Summary of FlyAtlas Anatomical Expression Data: High levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1623580_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of alphaTub84B. Gene sequence location is 3R:2912260..2914582.
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	αTub84B (α1t) A structural gene for α-Tubulin; present in one copy per haploid genome; transcribed into mRNA in the oocyte and the embryo, reaching a maximum concentration 6-9 hr after the egg is laid (Kalfayan and Wensink, 1982). A variety of post-translational modifications of αTub84b protein found in all tissues, some of which are tissue-specific (Matthews et al., 1989). The gene appears to be constitutively expressed, its functions being common to most cells; the resulting tubulins are very similar to those of other animal species (Theurkauf et al., 1986). Mutations in αTub84B have been induced as lethals over Df(3R)Scx2. Alleles αTub84B1 and αTub84B3 produce proteins that are electrophoretic variants of the wild-type tubulin. Based on the extent of lethality and sterility found in interallelic heterozygotes and in heterozygotes over wild type, the severity of αTub84B alleles can be ordered as follows: αTub84B6 < αTub84B1 < αTub84B2 < αTub84B4 < αTub84B5 = αTub84B3 (Matthews and Kaufman, 1987). Maternal-effect as well as zygotic lethality is shown by the more severe alleles. In the less severe hypomorphic alleles, heterozygotes die late in pupal life or early in adult life, the adults showing head, thoracic, or abdominal defects, bristle abnormalities, leg tremors, and sterility (Matthews and Kaufman, 1987).
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	References Koppen et al., 2011, Proteomics 11(22): 4397--4410 Ardehali et al., 2011, EMBO J. 30(14): 2817--2828 Meyer et al., 2011, Curr. Biol. 21(6): 485--491 Sequence features BKN28950 HFA12622
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 84B2-84B2   Limits computationally determined from genome sequence between P{lacW}l(3)L2100L2100 and P{EP}EP3060EP3060
Experimentally Determined Cytological Location
Cytogenetic map Notes References 84B-84B   (determined by in situ hybridisation)   (Drosopoulou and Scouras, 1998) 84B4-84C2   (determined by in situ hybridisation)   (Baker and Wolfner, 1988) 84B3-84B6   (determined by in situ hybridisation)   (Natzle and McCarthy, 1984) 84B3-84B6   (determined by in situ hybridisation)   (Mischke and Pardue, 1982) 84B3-84B6   (determined by in situ hybridisation)   (Kalfayan and Wensink, 1981) 84B3-84B6   (determined by in situ hybridisation)   (Sanchez et al., 1980)
Experimentally Determined Recombination Data
Location	3-47.7 (Hays et al., 1989, Green et al., 1990) 3-47.7 +/- 0.1 (Fuller, 1986)
Left of (cM)	p (Hays et al., 1989, Fuller, 1986)
Right of (cM)	Ki (Hays et al., 1989, Fuller, 1986)
Notes	Mapping based on seven recombinants. (Hays et al., 1989)
Gene Model & Products
Please see the GBrowse view of Dmel\αTub84B for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) αTub84B-RA FBtr0081639  NM_057424   1834   450
Additional Transcript Data & Comments
Reported size (kB)	2.250 (sequence analysis) (Theurkauf et al., 1986) 2.0 (northern blot) (Natzle and McCarthy, 1984) 1.75 (unknown) (Matthews et al., 1989) 1.8 (northern blot) (Kalfayan and Wensink, 1982) 1.3 (unknown) (Baum et al., 1983)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein alphaTub84B-PA   FBpp0081153   49.9   450   4.78     NP_476772   AAF54067
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Tubulin (IPR000217) Alpha tubulin (IPR002452) Tubulin/FtsZ, GTPase domain (IPR003008) Tubulin/FtsZ, C-terminal (IPR008280) Tubulin, conserved site (IPR017975) Tubulin/FtsZ, 2-layer sandwich domain (IPR018316) Tubulin, C-terminal (IPR023123)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201119   AA201178   AA201204   AA201225   AA201243   AA201285   AA201326   AA201387   AA201516   AA201609   AA201724   AA201731   AA201863   AA201906   AA202060   AA202277   AA202285   AA202347   AA202354   AA202397   AA202535   AA202731   AA202817   AA202919   AA202921   AA203042   AA203048   AA246215   AA246236   AA246280   AA246285   AA246303   AA246399   AA246478   AA246633   AA246684   AA246806   AA246826   AA246950   AA246963   AA247065   AA263211   AA263418   AA263420   AA263503   AA263577   AA263611   AA263619   AA263623   AA263629   AA263714   AA263783   AA263827   AA263924   AA263965   AA264072   AA264082   AA264161   AA264262   AA264366   AA264384   AA264456   AA264505   AA264636   AA264759   AA264777   AA264818   AA264899   AA390286   AA390366   AA390434   AA390440   AA390740   AA390757   AA390859   AA390874   AA390886   AA390959   AA391366   AA391500   AA391629   AA391655   AA391732   AA391838   AA391842   AA391846   AA392182   AA392238   AA392420   AA392672   AA392779   AA392905   AA392935   AA438308   AA438430   AA438444   AA438477   AA438547   AA438621   AA438673   AA438692   AA438750   AA438753   AA438827   AA438990   AA439012   AA439027   AA439117   AA439138   AA439200   AA439329   AA439490   AA439517   AA439594   AA439886   AA439950   AA440214   AA440269   AA440326   AA440338   AA440532   AA440843   AA441101   AA536291   AA536320   AA536336   AA536365   AA536432   AA538600   AA539262   AA539286   AA539289   AA539579   AA539719   AA539731   AA539776   AA539862   AA539997   AA540063   AA540272   AA540321   AA540325   AA540409   AA540466   AA540506   AA540581   AA540629   AA540739   AA540827   AA540847   AA540884   AA540992   AA541006   AA541013   AA567292   AA567385   AA567700   AA567798   AA694778   AA694814   AA694848   AA694920   AA694986   AA695043   AA695171   AA695914   AA696010   AA696086   AA696648   AA696758   AA696820   AA696976   AA697014   AA697147   AA697392   AA698178   AA698186   AA698224   AA698268   AA698682   AA698684   AA698987   AA699226   AA735121   AA735131   AA735134   AA735212   AA735213   AA735429   AA735434   AA735453   AA735527   AA735536   AA735543   AA735629   AA735634   AA735680   AA735808   AA735873   AA801491   AA801564   AA801649   AA801650   AA802336   AA802341   AA802348   AA802410   AA802433   AA802728   AA802921   AA803127   AA803245   AA803307   AA803365   AA803651   AA803970   AA803976   AA803979   AA804022   AA804068   AA816376   AA816424   AA816447   AA816525   AA816566   AA816568   AA816626   AA816627   AA816634   AA816635   AA816814   AA816912   AA817004   AA817027   AA817124   AA817131   AA817148   AA817181   AA817207   AA817220   AA817234   AA817291   AA817455   AA817627   AA817631   AA817653   AA820081   AA820118   AA820210   AA820259   AA820268   AA820293   AA820303   AA820337   AA820388   AA820390   AA820414   AA820467   AA820477   AA820536   AA820565   AA820586   AA820616   AA820663   AA820707   AA820766   AA820770   AA820816   AA820825   AA820849   AA821056   AA821127   AA940661   AA940785   AA940839   AA940902   AA940936   AA940945   AA940965   AA940971   AA940975   AA940988   AA941046   AA941060   AA941175   AA941306   AA941347   AA941427   AA941441   AA941451   AA941496   AA941510   AA941539   AA941569   AA941615   AA941620   AA941689   AA941711   AA941713   AA941764   AA941904   AA941935   AA942000   AA942015   AA942236   AA942366   AA942388   AA942416   AA942475   AA942608   AA942632   AA948786   AA948787   AA949209   AA949321   AA949390   AA949442   AA949593   AA949605   AA949671   AA949696   AA949709   AA949836   AA949888   AA949940   AA949988   AA950093   AA950177   AA950227   AA950270   AA950404   AA950425   AA950455   AA950494   AA950781   AA951035   AA951060   AA951134   AA951149   AA951218   AA951281   AA951376   AA951429   AA951536   AA951583   AA951630   AA951641   AA951656   AA951686   AA951687   AA951786   AA952001   AA952064   AA952066   AA952123   AA952236   AA952282   AA978517   AA978518   AA978636   AA978693   AA978714   AA978769   AA978946   AA979027   AA979049   AA979124   AA979133   AA979155   AA979224   AA979280   AA979333   AA979388   AA979573   AA979590   AA979594   AA979614   AA979650   AA990764   AA990796   AE014297 AAF54067   AC004266   AC008225   AI061787   AI061805   AI061827   AI061856   AI061929   AI061935   AI062299   AI062503   AI062657   AI062861   AI063401   AI063413   AI064361   AI106656   AI106844   AI108122   AI108195   AI108483   AI108807   AI109039   AI109167   AI109543   AI109699   AI109782   AI109927   AI109938   AI110136   AI113455   AI113546   AI113580   AI113754   AI114028   AI124284   AI124313   AI134016   AI134102   AI134134   AI134582   AI134804   AI238675   AI238718   AI238919   AI239151   AI256964   AI257293   AI257352   AI257511   AI257552   AI257576   AI257759   AI257776   AI258076   AI258561   AI258796   AI259240   AI259252   AI259312   AI259415   AI259449   AI259540   AI259588   AI259873   AI259938   AI260029   AI260050   AI260121   AI260893   AI261140   AI292500   AI292563   AI292743   AI293110   AI293579   AI293852   AI293894   AI294029   AI294083   AI294144   AI294401   AI294500   AI294502   AI294584   AI294828   AI294837   AI294899   AI294901   AI295086   AI295096   AI295164   AI295451   AI295497   AI295498   AI295877   AI295905   AI295958   AI296098   AI296159   AI296344   AI296410   AI296745   AI297089   AI297120   AI297614   AI297826   AI386980   AI387157   AI387611   AI387648   AI387786   AI387852   AI387935   AI387999   AI388293   AI388876   AI388936   AI389366   AI389789   AI402653   AI402752   AI402944   AI403791   AI404307   AI404320   AI404735   AI404896   AI405038   AI455045   AI455081   AI455215   AI455584   AI455588   AI455603   AI455652   AI455759   AI455764   AI455788   AI455821   AI455837   AI455858   AI455986   AI456034   AI456109   AI456164   AI456447   AI456448   AI456498   AI456545   AI456575   AI456615   AI456620   AI456663   AI456742   AI456771   AI456774   AI456788   AI456797   AI456862   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AI519191   AI519243   AI519298   AI519364   AI519375   AI519389   AI519465   AI519524   AI519578   AI519618   AI519659   AI519728   AI519772   AI519831   AI519934   AI519955   AI519994   AI520031   AI520109   AI520156   AI520157   AI520414   AI520576   AI520583   AI520592   AI520619   AI531791   AI532237   AI532811   AI532972   AI533067   AI533341   AI534238   AI534350   AI534530   AI541678   AI542138   AI542910   AI543122   AI543222   AI543576   AI543864   AI543881   AI543943   AI544139   AI546294   AI546338   AI546448   AI546471   AI546489   AI945630   AK281777   AK282586   AY113631   AY231787   AY432371   BE975007   BE975236   BE975796   BE975797   BE976281   BE976419   BE977301   BE977621   BE977719   BE978165   BE978166   BE978202   BE978730   BE978790   BF485693   BF485980   BF486327   BF486748   BF487150   BF487807   BF487938   BF487966   BF488009   BF488102   BF488275   BF488433   BF488614   BF488853   BF489120   BF489137   BF489145   BF489603   BF489730   BF489793   BF490040   BF490199   BF490539   BF490622   BF490689   BF490721   BF490756   BF491312   BF491562   BF492000   BF492008   BF492323   BF492347   BF492370   BF492506   BF492507   BF492537   BF492538   BF492586   BF492587   BF493138   BF493194   BF493257   BF493303   BF493385   BF493386   BF493762   BF493918   BF494005   BF494031   BF494277   BF494980   BF494981   BF494995   BF495005   BF495280   BF495463   BF495655   BF495773   BF496060   BF496154   BF496617   BF496912   BF496919   BF497125   BF497254   BF497331   BF497409   BF497615   BF498247   BF498307   BF498437   BF498640   BF498956   BF499136   BF499223   BF499320   BF499580   BF499607   BF499732   BF499943   BF500054   BF500352   BF500400   BF500639   BF500645   BF500656   BF500927   BF501095   BF501364   BF501523   BF501896   BF501912   BF501953   BF502158   BF502290   BF502348   BF502411   BF502428   BF502629   BF502710   BF503003   BF503114   BF503374   BF503500   BF503536   BF503564   BF503565   BF503569   BF503761   BF503768   BF503948   BF504057   BF504062   BF504195   BF504416   BF504701   BF504713   BF504726   BF504802   BF504882   BF505122   BF505276   BF505355   BF505470   BF505487   BF505633   BF505709   BF505808   BF506202   BF506231   BF506385   BF506494   BG632008   BG632029   BG632729   BG633761   BG633793   BG633818   BG633851   BG634181   BG634217   BG634221   BG634446   BG634734   BG634765   BG634903   BG635342   BG635411   BG635470   BG635471   BG635720   BG635982   BG636135   BG636319   BG636467   BG636621   BG636665   BG636963   BG636983   BG637017   BG637297   BG637361   BG638485   BG638907   BG638974   BG639119   BG640170   BG640492   BG641273   BG641420   BI141829   BI141836   BI142176   BI142182   BI162065   BI162066   BI163458   BI164081   BI164216   BI164310   BI164320   BI165529   BI165569   BI165926   BI166059   BI166108   BI166325   BI166360   BI166447   BI166638   BI166696   BI167357   BI170037   BI170595   BI170918   BI171154   BI171353   BI171954   BI172228   BI172419   BI172520   BI173544   BI173653   BI212933   BI212981   BI213355   BI214981   BI215667   BI216035   BI216086   BI216916   BI216978   BI216983   BI227891   BI227911   BI228027   BI228089   BI228242   BI228546   BI228946   BI229151   BI229301   BI229429   BI229452   BI229655   BI230104   BI231063   BI231319   BI231456   BI231528   BI231598   BI231637   BI231652   BI231736   BI231785   BI231926   BI232351   BI232491   BI233057   BI233294   BI234415   BI234928   BI235157   BI235191   BI236059   BI236213   BI236369   BI236738   BI237080   BI237731   BI237772   BI238749   BI239499   BI239742   BI239783   BI240016   BI240037   BI240104   BI240110   BI240411   BI240492   BI240738   BI240803   BI241513   BI242032   BI242222   BI242831   BI243620   BI243735   BI351633   BI351638   BI351726   BI351806   BI351825   BI351836   BI351976   BI352078   BI352101   BI352354   BI352368   BI352389   BI352836   BI352859   BI352915   BI352929   BI353079   BI353193   BI353225   BI353308   BI353364   BI353427   BI353502   BI353852   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BI572718   BI573047   BI573110   BI574114   BI576045   BI576138   BI576846   BI579397   BI579971   BI580241   BI580993   BI580994   BI581718   BI582221   BI583025   BI583074   BI583903   BI584486   BI584543   BI586705   BI586980   BI586996   BI587950   BI588170   BI588414   BI588639   BI588727   BI590549   BI590684   BI591124   BI591161   BI591165   BI591195   BI592292   BI592358   BI592620   BI592757   BI592784   BI605436   BI605484   BI606576   BI606977   BI607843   BI611173   BI611255   BI612364   BI612632   BI613443   BI613618   BI613953   BI614023   BI615059   BI616611   BI616686   BI616770   BI617050   BI617078   BI617792   BI618990   BI619019   BI619175   BI619959   BI620008   BI620423   BI620528   BI620542   BI621023   BI621197   BI621934   BI621990   BI622262   BI623327   BI624695   BI628585   BI629286   BI629391   BI629525   BI630349   BI631753   BI631942   BI632561   BI632578   BI632684   BI633113   BI633148   BI633830   BI634225   BI634402   BI634500   BI635159   BI635256   BI635781   BI636038   BI636549   BI636832   BI638491   BI638916   BI638959   BI639043   BI639139   BI639630   BI639671   BI639976   BI640056   BI640569   BI640930   BI640992   BI641288   BP550893   BP554879   BP554880   BQ103265   BT012506   BT016118   BT044334   BX005570   BX006068   BX006881   BX007757   BX007996   BX011538   BX012892   BX014125   BX015701   BX016319   BX016721   BX017052   BX019574   BX020136   BX020626   BX020651   BX020705   BX021143   BX022214   BX023695   BX024443   BX025754   BX026827   BX028325   BX029685   BX029799   BX031517   BX032230   BX033080   BX034162   BX034268   BX034454   BX037080   BX038833   BX044536   BX047506   BX051458   BX053542   BX056628   BX057344   BX060127   BX061026   BX061199   BX062157   BX063462   BX064928   BX065134   BX069757   BX070179   BX071989   BX072076   CA807308   CA807456   CK131824   CK131880   CK131896   CK132008   CK132116   CK132293   CK132351   CK132985   CK445185   CK604437   CK604438   CK604571   CK604572   CK604736   CK604737   CK605181   CK605182   CK605271   CK605272   CK605473   CK657178   CK657377   CK657383   CK657691   CK657739   CK657760   CK658078   CK658262   CK658340   CK658479   CK658661   CK658732   CK658872   CK658888   CK659059   CK659188   CK659274   CK659281   CK659391   CK659604   CK659719   CK659831   CK659862   CK660084   CK660120   CK660137   CK660199   CK660223   CK660244   CK660303   CK660364   CK660491   CK660642   CK660756   CK660763   CK660843   CK660855   CK661018   CK661036   CK661086   CK661106   CK661346   CK661381   CK661463   CK661644   CK661658   CK661739   CK661740   CK661758   CK661958   CK662009   CK662198   CK662284   CO152686   CO153232   CO153758   CO153852   CO153890   CO153941   CO153951   CO154026   CO154110   CO155125   CO155155   CO155668   CO156161   CO156476   CO156793   CO156898   CO156935   CO183298   CO185636   CO194774   CO195021   CO263857   CO268092   CO278885   CO293736   CO294985   CO301356   CO302369   CO306043   CO307121   CO307790   CO311646   CO317702   CO332798   CO335369   CO335559   CO335702   CO336144   CO336194   CO336322   CO336345   CO336421   CO336573   CO336674   CO336766   CO337538   CO337621   CO337632   CO337829   CO338239   CO338719   CR938635   DN154505   DQ440241   DQ675550   EC051363   EC057081   EC057900   EC063852   EC076278   EC076591   EC082460   EC085531   EC088521   EC088722   EC201587   EC202289   EC203564   EC214958   EC216650   EC227029   EC228015   EC233963   EC239053   EC243973   EC249061   EC249877   EC261223   EC261418   EC261422   EC261593   EC261688   EC261701   EC261781   EC261845   EC261857   EC262061   EC262460   EC262589   EC262749   EC262777   EC263108   EC263167   EC263283   EC263391   EC263476   EC263696   EC263720   EC263928   EC264724   EC264782   EC264829   EC264897   EC264919   EC265515   EC265650   EC265905   EC265976   EC266834   EC266886   EC267025   EC267344   EC267619   EC267664   EC267799   EL876607   EL876608   EL876708   EL876709   EL876819   EL882243   ES691301   ES691636   ES693989   ES694422   ES694454   ES694483   ES694487   ES694540   ES694572   ES694653   ES694724   ES694731   ES695175   ES695296   EV577982   EV578693   EV578741   EV579148   EV579185   EV579798   EV580971   EV581317   EV582339   EV582857   EV583305   EV583456   EV583875   EV585946   EV586118   EV586182   EV586906   EV588704   EV589604   EV589850   EV590013   EV590381   EV591653   EV592413   EV592747   EV593760   EV594578   M14643 AAA28985
UniProtKB/Swiss-Prot	P06603
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References protein binding site FBsf0000159931 3R:2,912,174..2,912,190 bound_moiety=Trl-XP comment=G3 evidence=experimental (O'Donnell and Wensink, 1994, Bergman et al., 2004) protein binding site FBsf0000159930 3R:2,912,203..2,912,215 comment=G2 evidence=experimental bound_moiety=Trl-XP (O'Donnell and Wensink, 1994, Bergman et al., 2004) protein binding site FBsf0000161129 3R:2,912,212..2,912,230 comment=T2 evidence=experimental bound_moiety=Tbf1-XP (O'Donnell and Wensink, 1994, Bergman et al., 2004) protein binding site FBsf0000159929 3R:2,912,222..2,912,237 comment=G1 evidence=experimental bound_moiety=Trl-XP (O'Donnell and Wensink, 1994, Bergman et al., 2004) protein binding site FBsf0000159928 3R:2,912,239..2,912,250 comment=T1 evidence=experimental bound_moiety=Tbf1-XP (O'Donnell and Wensink, 1994, Bergman et al., 2004) protein binding site FBsf0000159925 3R:2,912,698..2,912,710 bound_moiety=Tbf1-XP comment=T5 evidence=experimental (O'Donnell and Wensink, 1994, Bergman et al., 2004) protein binding site FBsf0000159927 3R:2,912,729..2,912,751 evidence=experimental bound_moiety=Tbf1-XP comment=T3 (Bergman et al., 2004, O'Donnell and Wensink, 1994) protein binding site FBsf0000159926 3R:2,912,829..2,912,833 comment=T4 evidence=experimental bound_moiety=Tbf1-XP (O'Donnell and Wensink, 1994, Bergman et al., 2004) protein binding site FBsf0000160508 3R:2,912,768..2,912,795 bound_moiety=Trl-XP evidence=experimental (O'Donnell and Wensink, 1994, Bergman et al., 2004) protein binding site FBsf0000160509 3R:2,912,848..2,912,861 bound_moiety=Trl-XP evidence=experimental (O'Donnell and Wensink, 1994, Bergman et al., 2004) protein binding site FBsf0000161114 3R:2,912,221..2,912,250 evidence=experimental (Bergman et al., 2004, O'Donnell and Wensink, 1994) protein binding site FBsf0000161115 3R:2,912,811..2,912,822 bound_moiety=Trl-XP evidence=experimental (O'Donnell and Wensink, 1994, Bergman et al., 2004) regulatory region FBsf0000161322 3R:2,912,166..2,912,233 comment=One of three regions that activate transcription in in vitro assays comment=Tubulin Element 2 (TE2) evidence=experimental (O'Donnell et al., 1994) regulatory region FBsf0000161323 3R:2,912,234..2,912,262 comment=One of three regions that activate transcription in in vitro assays comment=Tubulin Element 1 (TE1) evidence=experimental (O'Donnell et al., 1994) regulatory region FBsf0000161324 3R:2,912,467..2,912,955 comment=One of three regions that activate transcription in in vitro assays evidence=experimental (O'Donnell et al., 1994)
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Matthews et al., 1989) embryonic stage 1 -- 15     (Kalfayan and Wensink, 1982) Comment:reference states 0-12 hr AEL embryonic stage 1 -- 17     (Natzle and McCarthy, 1984) Comment:reference states 0-21 hr AEL larval stage     (Kalfayan and Wensink, 1982) first instar larval stage     (Natzle and McCarthy, 1984) second instar larval stage     (Natzle and McCarthy, 1984) third instar larval stage     (Natzle and McCarthy, 1984) prepupal stage     (Natzle and McCarthy, 1984) pupal stage     (Kalfayan and Wensink, 1982, Natzle and McCarthy, 1984) adult stage     (Kalfayan and Wensink, 1982)
Additional Descriptive Data
	αTub84B transcript is detected in all developmental stages. (Matthews et al., 1989) Expression ofαTub84B is abundant throughout development, with the highest concentrationof transcript expressed at 6-9 hours of embryonic development. (Kalfayan and Wensink, 1982) The αTub84Btranscript is expressed at all stages of development, with highest levelsdetected betweeen 0 and 6 hours of embryonic development, and high levelsbetween 9 and 18 hours of embryonic development and the first and second larvalinstars. (Natzle and McCarthy, 1984)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference wandering third instar larval stage   neuromuscular junction   • microtubule of axon (Trotta et al., 2004) Comment:not in synaptic boutons muscle cell   (Trotta et al., 2004) mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Dorus et al., 2006, Wasbrough et al., 2010) day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011) western blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 4     (Matthews et al., 1989) Comment:reference states 0-2 hr AEL embryonic stage 12 -- 15     (Matthews et al., 1989) Comment:reference states 9-13 hr AEL embryonic stage 17     (Matthews et al., 1989) Comment:reference states 16-20 hr AEL third instar larval stage   imaginal disc   (Matthews et al., 1989) central nervous system   (Matthews et al., 1989) pupal stage | mid     (Matthews et al., 1989) adult stage   gonad   (Matthews et al., 1989)   (Matthews et al., 1989) adult head   (Matthews et al., 1989)
Additional Descriptive Data
	To compare synthesis and accumulation of α-tubulin proteins, 35S</up>methionine radiolabeled tissues were subjected to Western analysis using monoclonal anti-α-tubulin antibody. The predominant α-tubulin protein in all tissues and stages examined is αTub84B protein. The protein did not accumulate in the adult head. (Matthews et al., 1989) localization of acetylated or glutamylated tubulin detected; found only in stabilized microtubules. (Trotta et al., 2004)
Marker for
	microtubule &&of neuromuscular junction
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0003884    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0003884 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely high expression to a trough of very high expression. Peak expression observed within 00-18 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0003884 expression level Developmental Stage   Expression Level embryo 00-02hr    124533 embryo 02-04hr    239132 embryo 04-06hr    307076 embryo 06-08hr    317992 embryo 08-10hr    219037 embryo 10-12hr    207209 embryo 12-14hr    155565 embryo 14-16hr    205843 embryo 16-18hr    113319 embryo 18-20hr    91062 embryo 20-22hr    67741 embryo 22-24hr    59562 larva L1    114792 larva L2    153562 larva L3 12hr old    121123 larva L3 puffstage 1-2    98840 larva L3 puffstage 3-6    109985 larva L3 puffstage 7-9    125088 white prepupae new    149463 white prepupae 12hr    138244 white prepupae 24hr    202542 pupae 2d postWPP    218077 pupae 3d postWPP    134920 pupae 4d postWPP    130579 adult male 01day    77606 adult male 05day    97362 adult male 30day    95485 adult female 01day    86156 adult female 05day    83531 adult female 30day    82528 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (124533) embryo 02-04hr  (239132) embryo 04-06hr  (307076) embryo 06-08hr  (317992) embryo 08-10hr  (219037) embryo 10-12hr  (207209) embryo 12-14hr  (155565) embryo 14-16hr  (205843) embryo 16-18hr  (113319) embryo 18-20hr  (91062) embryo 20-22hr  (67741) embryo 22-24hr  (59562) larva L1  (114792) larva L2  (153562) larva L3 12hr old  (121123) larva L3 puffstage 1-2  (98840) larva L3 puffstage 3-6  (109985) larva L3 puffstage 7-9  (125088) white prepupae new  (149463) white prepupae 12hr  (138244) white prepupae 24hr  (202542) pupae 2d postWPP  (218077) pupae 3d postWPP  (134920) pupae 4d postWPP  (130579) adult male 01day  (77606) adult male 05day  (97362) adult male 30day  (95485) adult female 01day  (86156) adult female 05day  (83531) adult female 30day  (82528) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (124533) embryo 02-04hr  (239132) embryo 04-06hr  (307076) embryo 06-08hr  (317992) embryo 08-10hr  (219037) embryo 10-12hr  (207209) embryo 12-14hr  (155565) embryo 14-16hr  (205843) embryo 16-18hr  (113319) embryo 18-20hr  (91062) embryo 20-22hr  (67741) embryo 22-24hr  (59562) larva L1  (114792) larva L2  (153562) larva L3 12hr old  (121123) larva L3 puffstage 1-2  (98840) larva L3 puffstage 3-6  (109985) larva L3 puffstage 7-9  (125088) white prepupae new  (149463) white prepupae 12hr  (138244) white prepupae 24hr  (202542) pupae 2d postWPP  (218077) pupae 3d postWPP  (134920) pupae 4d postWPP  (130579) adult male 01day  (77606) adult male 05day  (97362) adult male 30day  (95485) adult female 01day  (86156) adult female 05day  (83531) adult female 30day  (82528) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (124533) embryo 02-04hr  (239132) embryo 04-06hr  (307076) embryo 06-08hr  (317992) embryo 08-10hr  (219037) embryo 10-12hr  (207209) embryo 12-14hr  (155565) embryo 14-16hr  (205843) embryo 16-18hr  (113319) embryo 18-20hr  (91062) embryo 20-22hr  (67741) embryo 22-24hr  (59562) larva L1  (114792) larva L2  (153562) larva L3 12hr old  (121123) larva L3 puffstage 1-2  (98840) larva L3 puffstage 3-6  (109985) larva L3 puffstage 7-9  (125088) white prepupae new  (149463) white prepupae 12hr  (138244) white prepupae 24hr  (202542) pupae 2d postWPP  (218077) pupae 3d postWPP  (134920) pupae 4d postWPP  (130579) adult male 01day  (77606) adult male 05day  (97362) adult male 30day  (95485) adult female 01day  (86156) adult female 05day  (83531) adult female 30day  (82528) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    124533 embryo 02-04hr    239132 embryo 04-06hr    307076 embryo 06-08hr    317992 embryo 08-10hr    219037 embryo 10-12hr    207209 embryo 12-14hr    155565 embryo 14-16hr    205843 embryo 16-18hr    113319 embryo 18-20hr    91062 embryo 20-22hr    67741 embryo 22-24hr    59562 larva L1    114792 larva L2    153562 larva L3 12hr old    121123 larva L3 puffstage 1-2    98840 larva L3 puffstage 3-6    109985 larva L3 puffstage 7-9    125088 white prepupae new    149463 white prepupae 12hr    138244 white prepupae 24hr    202542 pupae 2d postWPP    218077 pupae 3d postWPP    134920 pupae 4d postWPP    130579 adult male 01day    77606 adult male 05day    97362 adult male 30day    95485 adult female 01day    86156 adult female 05day    83531 adult female 30day    82528 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0003884 expression level Developmental Stage   Expression Level embryo 00-02hr    124533 embryo 02-04hr    239132 embryo 04-06hr    307076 embryo 06-08hr    317992 embryo 08-10hr    219037 embryo 10-12hr    207209 embryo 12-14hr    155565 embryo 14-16hr    205843 embryo 16-18hr    113319 embryo 18-20hr    91062 embryo 20-22hr    67741 embryo 22-24hr    59562 larva L1    114792 larva L2    153562 larva L3 12hr old    121123 larva L3 puffstage 1-2    98840 larva L3 puffstage 3-6    109985 larva L3 puffstage 7-9    125088 white prepupae new    149463 white prepupae 12hr    138244 white prepupae 24hr    202542 pupae 2d postWPP    218077 pupae 3d postWPP    134920 pupae 4d postWPP    130579 adult male 01day    77606 adult male 05day    97362 adult male 30day    95485 adult female 01day    86156 adult female 05day    83531 adult female 30day    82528 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (124533) embryo 02-04hr  (239132) embryo 04-06hr  (307076) embryo 06-08hr  (317992) embryo 08-10hr  (219037) embryo 10-12hr  (207209) embryo 12-14hr  (155565) embryo 14-16hr  (205843) embryo 16-18hr  (113319) embryo 18-20hr  (91062) embryo 20-22hr  (67741) embryo 22-24hr  (59562) larva L1  (114792) larva L2  (153562) larva L3 12hr old  (121123) larva L3 puffstage 1-2  (98840) larva L3 puffstage 3-6  (109985) larva L3 puffstage 7-9  (125088) white prepupae new  (149463) white prepupae 12hr  (138244) white prepupae 24hr  (202542) pupae 2d postWPP  (218077) pupae 3d postWPP  (134920) pupae 4d postWPP  (130579) adult male 01day  (77606) adult male 05day  (97362) adult male 30day  (95485) adult female 01day  (86156) adult female 05day  (83531) adult female 30day  (82528) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (124533) embryo 02-04hr  (239132) embryo 04-06hr  (307076) embryo 06-08hr  (317992) embryo 08-10hr  (219037) embryo 10-12hr  (207209) embryo 12-14hr  (155565) embryo 14-16hr  (205843) embryo 16-18hr  (113319) embryo 18-20hr  (91062) embryo 20-22hr  (67741) embryo 22-24hr  (59562) larva L1  (114792) larva L2  (153562) larva L3 12hr old  (121123) larva L3 puffstage 1-2  (98840) larva L3 puffstage 3-6  (109985) larva L3 puffstage 7-9  (125088) white prepupae new  (149463) white prepupae 12hr  (138244) white prepupae 24hr  (202542) pupae 2d postWPP  (218077) pupae 3d postWPP  (134920) pupae 4d postWPP  (130579) adult male 01day  (77606) adult male 05day  (97362) adult male 30day  (95485) adult female 01day  (86156) adult female 05day  (83531) adult female 30day  (82528) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (124533) embryo 02-04hr  (239132) embryo 04-06hr  (307076) embryo 06-08hr  (317992) embryo 08-10hr  (219037) embryo 10-12hr  (207209) embryo 12-14hr  (155565) embryo 14-16hr  (205843) embryo 16-18hr  (113319) embryo 18-20hr  (91062) embryo 20-22hr  (67741) embryo 22-24hr  (59562) larva L1  (114792) larva L2  (153562) larva L3 12hr old  (121123) larva L3 puffstage 1-2  (98840) larva L3 puffstage 3-6  (109985) larva L3 puffstage 7-9  (125088) white prepupae new  (149463) white prepupae 12hr  (138244) white prepupae 24hr  (202542) pupae 2d postWPP  (218077) pupae 3d postWPP  (134920) pupae 4d postWPP  (130579) adult male 01day  (77606) adult male 05day  (97362) adult male 30day  (95485) adult female 01day  (86156) adult female 05day  (83531) adult female 30day  (82528) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    124533 embryo 02-04hr    239132 embryo 04-06hr    307076 embryo 06-08hr    317992 embryo 08-10hr    219037 embryo 10-12hr    207209 embryo 12-14hr    155565 embryo 14-16hr    205843 embryo 16-18hr    113319 embryo 18-20hr    91062 embryo 20-22hr    67741 embryo 22-24hr    59562 larva L1    114792 larva L2    153562 larva L3 12hr old    121123 larva L3 puffstage 1-2    98840 larva L3 puffstage 3-6    109985 larva L3 puffstage 7-9    125088 white prepupae new    149463 white prepupae 12hr    138244 white prepupae 24hr    202542 pupae 2d postWPP    218077 pupae 3d postWPP    134920 pupae 4d postWPP    130579 adult male 01day    77606 adult male 05day    97362 adult male 30day    95485 adult female 01day    86156 adult female 05day    83531 adult female 30day    82528 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0003884    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0003884 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0003884 expression level Tissue   Expression Level Larval Central Nervous System    2890.375 Larval Midgut    5886.3 Larval Hindgut    4908.8 Larval Malpighian Tubules    3259.4 Larval Fat Body    3469.2 Larval Salivary Gland    6429.8 Larval Trachea    4580.725 Larval Carcass    4742.625 Adult Head    2444.9 Adult Eye    2302.8 Adult Brain    2669.6 Adult Thoracic-Abdominal Ganglion    3498 Adult Crop    2928.8 Adult Midgut    2406.8 Adult Hindgut    2897.4 Adult Malpighian Tubules    2740.5 Adult Fat Body    2723.8 Adult Salivary Gland    2046.3 Adult Heart    1328.55 Adult VirginFemale Spermatheca    3066 Adult InseminatedFemale Spermatheca    3298 Adult Ovary    2546.8 Adult Testis    2961 Adult Male Accessory Gland    2686.4 Adult Carcass    2179.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (2890.375) Larval Midgut  (5886.3) Larval Hindgut  (4908.8) Larval Malpighian Tubules  (3259.4) Larval Fat Body  (3469.2) Larval Salivary Gland  (6429.8) Larval Trachea  (4580.725) Larval Carcass  (4742.625) Adult Head  (2444.9) Adult Eye  (2302.8) Adult Brain  (2669.6) Adult Thoracic-Abdominal Ganglion  (3498) Adult Crop  (2928.8) Adult Midgut  (2406.8) Adult Hindgut  (2897.4) Adult Malpighian Tubules  (2740.5) Adult Fat Body  (2723.8) Adult Salivary Gland  (2046.3) Adult Heart  (1328.55) Adult VirginFemale Spermatheca  (3066) Adult InseminatedFemale Spermatheca  (3298) Adult Ovary  (2546.8) Adult Testis  (2961) Adult Male Accessory Gland  (2686.4) Adult Carcass  (2179.1) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (2890.375) Larval Midgut  (5886.3) Larval Hindgut  (4908.8) Larval Malpighian Tubules  (3259.4) Larval Fat Body  (3469.2) Larval Salivary Gland  (6429.8) Larval Trachea  (4580.725) Larval Carcass  (4742.625) Adult Head  (2444.9) Adult Eye  (2302.8) Adult Brain  (2669.6) Adult Thoracic-Abdominal Ganglion  (3498) Adult Crop  (2928.8) Adult Midgut  (2406.8) Adult Hindgut  (2897.4) Adult Malpighian Tubules  (2740.5) Adult Fat Body  (2723.8) Adult Salivary Gland  (2046.3) Adult Heart  (1328.55) Adult VirginFemale Spermatheca  (3066) Adult InseminatedFemale Spermatheca  (3298) Adult Ovary  (2546.8) Adult Testis  (2961) Adult Male Accessory Gland  (2686.4) Adult Carcass  (2179.1) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    2890.375 Larval Midgut    5886.3 Larval Hindgut    4908.8 Larval Malpighian Tubules    3259.4 Larval Fat Body    3469.2 Larval Salivary Gland    6429.8 Larval Trachea    4580.725 Larval Carcass    4742.625 Adult Head    2444.9 Adult Eye    2302.8 Adult Brain    2669.6 Adult Thoracic-Abdominal Ganglion    3498 Adult Crop    2928.8 Adult Midgut    2406.8 Adult Hindgut    2897.4 Adult Malpighian Tubules    2740.5 Adult Fat Body    2723.8 Adult Salivary Gland    2046.3 Adult Heart    1328.55 Adult VirginFemale Spermatheca    3066 Adult InseminatedFemale Spermatheca    3298 Adult Ovary    2546.8 Adult Testis    2961 Adult Male Accessory Gland    2686.4 Adult Carcass    2179.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0003884 expression level Tissue   Expression Level Larval Central Nervous System    2890.375 Larval Midgut    5886.3 Larval Hindgut    4908.8 Larval Malpighian Tubules    3259.4 Larval Fat Body    3469.2 Larval Salivary Gland    6429.8 Larval Trachea    4580.725 Larval Carcass    4742.625 Adult Head    2444.9 Adult Eye    2302.8 Adult Brain    2669.6 Adult Thoracic-Abdominal Ganglion    3498 Adult Crop    2928.8 Adult Midgut    2406.8 Adult Hindgut    2897.4 Adult Malpighian Tubules    2740.5 Adult Fat Body    2723.8 Adult Salivary Gland    2046.3 Adult Heart    1328.55 Adult VirginFemale Spermatheca    3066 Adult InseminatedFemale Spermatheca    3298 Adult Ovary    2546.8 Adult Testis    2961 Adult Male Accessory Gland    2686.4 Adult Carcass    2179.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (2890.375) Larval Midgut  (5886.3) Larval Hindgut  (4908.8) Larval Malpighian Tubules  (3259.4) Larval Fat Body  (3469.2) Larval Salivary Gland  (6429.8) Larval Trachea  (4580.725) Larval Carcass  (4742.625) Adult Head  (2444.9) Adult Eye  (2302.8) Adult Brain  (2669.6) Adult Thoracic-Abdominal Ganglion  (3498) Adult Crop  (2928.8) Adult Midgut  (2406.8) Adult Hindgut  (2897.4) Adult Malpighian Tubules  (2740.5) Adult Fat Body  (2723.8) Adult Salivary Gland  (2046.3) Adult Heart  (1328.55) Adult VirginFemale Spermatheca  (3066) Adult InseminatedFemale Spermatheca  (3298) Adult Ovary  (2546.8) Adult Testis  (2961) Adult Male Accessory Gland  (2686.4) Adult Carcass  (2179.1) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (2890.375) Larval Midgut  (5886.3) Larval Hindgut  (4908.8) Larval Malpighian Tubules  (3259.4) Larval Fat Body  (3469.2) Larval Salivary Gland  (6429.8) Larval Trachea  (4580.725) Larval Carcass  (4742.625) Adult Head  (2444.9) Adult Eye  (2302.8) Adult Brain  (2669.6) Adult Thoracic-Abdominal Ganglion  (3498) Adult Crop  (2928.8) Adult Midgut  (2406.8) Adult Hindgut  (2897.4) Adult Malpighian Tubules  (2740.5) Adult Fat Body  (2723.8) Adult Salivary Gland  (2046.3) Adult Heart  1328.55 Adult VirginFemale Spermatheca  (3066) Adult InseminatedFemale Spermatheca  (3298) Adult Ovary  (2546.8) Adult Testis  (2961) Adult Male Accessory Gland  (2686.4) Adult Carcass  (2179.1) Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    2890.375 Larval Midgut    5886.3 Larval Hindgut    4908.8 Larval Malpighian Tubules    3259.4 Larval Fat Body    3469.2 Larval Salivary Gland    6429.8 Larval Trachea    4580.725 Larval Carcass    4742.625 Adult Head    2444.9 Adult Eye    2302.8 Adult Brain    2669.6 Adult Thoracic-Abdominal Ganglion    3498 Adult Crop    2928.8 Adult Midgut    2406.8 Adult Hindgut    2897.4 Adult Malpighian Tubules    2740.5 Adult Fat Body    2723.8 Adult Salivary Gland    2046.3 Adult Heart    1328.55 Adult VirginFemale Spermatheca    3066 Adult InseminatedFemale Spermatheca    3298 Adult Ovary    2546.8 Adult Testis    2961 Adult Male Accessory Gland    2686.4 Adult Carcass    2179.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    2444.9   NA  Eye    2302.8   NA  Brain    2669.6   2890.375  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    3498   NA  Crop    2928.8   5886.3  Midgut    2406.8   4908.8  Hindgut    2897.4   3259.4  Malpighian Tubules    2740.5   3469.2  Fat Body    2723.8   6429.8  Salivary Gland    2046.3   NA  Heart    1328.55   4580.725  Trachea    NA   NA  VirginFemale Spermatheca    3066   NA  InseminatedFemale Spermatheca    3298   NA  Ovary    2546.8   NA  Testis    2961   NA  Male Accessory Gland    2686.4   4742.625  Carcass    2179.1 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_31
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003884 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1913-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal αTub84B1 αTub84B2 αTub84B3 lethal | recessive αTub84B1 αTub84B2 αTub84B5 αTub84B6 semi-lethal, with Scer\GAL4pnr-MD237 αTub84BGD9679 viable αTub84B7 viable, with Scer\GAL4nos.PG, Scer\GAL4nos.UTR.T:Hsim\VP16 αTub84BScer\UAS.P\T.T:Avic\GFP-S65C Sterility Allele female fertile | poor αTub84B7 male fertile αTub84B+t4.5 male semi-sterile (with αTub84B2) αTub84Bunspecified male semi-sterile (with αTub84B5) αTub84Bunspecified male semi-sterile (with αTub84B6) αTub84Bunspecified male semi-sterile (with αTub84B7) αTub84Bunspecified male semi-sterile (with αTub84Bunspecified) αTub84B2 αTub84B5 αTub84B6 αTub84B7 male sterile αTub84B7 male sterile | recessive αTub84B7 Other Phenotypes Allele visible, with Scer\GAL4pnr-MD237 αTub84BGD9679 wild-type αTub84B+t4.8 Phenotype manifest in Allele mesothoracic tergum, with Scer\GAL4pnr-MD237 αTub84BGD9679 spermatid αTub84Ba.βTub85D synapse & microtubule, with Scer\GAL4how-24B αTub84BScer\UAS.T:Hsap\MYC
Classical Alleles ( 9 )
For All Classical Alleles Show
Allele of αTub84B Class Mutagen Stocks Known lesion αTub84B5 amorphic allele - genetic evidence, hypomorphic allele - genetic evidence ethyl methanesulfonate 2 -- αTub84B7 hypomorphic allele - genetic evidence ethyl methanesulfonate 2 Yes αTub84BEY02851 P-element activity 1 -- αTub84B3 amorphic allele - genetic evidence ethyl methanesulfonate 0 Yes αTub84B1 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes αTub84B2 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes αTub84B4 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 -- αTub84B6 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 -- αTub84Bunspecified 0 --
Alleles Carried on Transgenic Constructs ( 30 )
For All Alleles Carried on Transgenic Constructs Show
Allele of αTub84B Class Mutagen Stocks Known lesion αTub84BAct5C.T:Avic\GFP-S65C,T:Zzzz\His6,T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - coding region fusion 3 Yes αTub84BScer\UAS.P\T.T:Avic\GFP-S65C in vitro construct - regulatory fusion in vitro construct - coding region fusion 3 Yes αTub84BGD17779 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes αTub84BScer\UAS.P\T.T:Avic\GFP-PA in vitro construct - regulatory fusion in vitro construct - coding region fusion 2 Yes αTub84BScer\UAS.T:Avic\GFP-S65C in vitro construct - regulatory fusion in vitro construct - coding region fusion 2 Yes αTub84BScer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 2 Yes αTub84BGD9679 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes αTub84BJF01373 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes αTub84BKK108950 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes αTub84B+t4.5 in vitro construct - genomic fragment 0 Yes αTub84B+t4.8 in vitro construct - genomic fragment 0 Yes αTub84B-157:+696.T:Ecol\lacZ in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes αTub84B-2000:+696.T:Ecol\lacZ in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes αTub84B-250:+696.T:Ecol\lacZ in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes αTub84B-320:+696.T:Ecol\lacZ in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes αTub84B-600:+696.T:Ecol\lacZ in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes αTub84B7.tHa in vitro construct - genomic fragment 0 Yes αTub84B7XH in vitro construct 0 Yes αTub84Ba.βTub85D in vitro construct - regulatory fusion 0 Yes αTub84BAct5C.T:Disc\RFP-mCherry in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes αTub84BhseΔint.T:Ecol\lacZ in vitro construct - regulatory fusion 0 Yes αTub84BRpP1.189 in vitro construct - deletion 0 Yes αTub84BRpP1.250 in vitro construct - regulatory fusion 0 Yes αTub84BRpP1.92 in vitro construct - regulatory fusion 0 Yes αTub84BUbi-p63E.T:Avic\GFP-S65C in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes αTub84BXH in vitro construct 0 Yes αTub84BΔint.T:Ecol\lacZ in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes αTub84BΔTE1.T:Ecol\lacZ in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes αTub84BΔTE1:TE2.T:Ecol\lacZ in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes αTub84BΔTE2.T:Ecol\lacZ in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Antp2 (Hays et al., 1989) Df(3R)Antp17 (Wakimoto et al., 1984, Raff, 1984, Hays et al., 1989, Kaufman et al., 1990, Baker et al., 1991, Theurkauf, 1992) Df(3R)Antp-A41 (Cavener et al., 1986, Hays et al., 1989) Df(3R)Antp-X1 (Cavener et al., 1986) Df(3R)Scx2 (Wakimoto et al., 1984, Raff, 1984, Cavener et al., 1986, Matthews and Kaufman, 1987, Hays et al., 1989, Kaufman et al., 1990) Df(3R)Scx4 (Cavener et al., 1986, Hays et al., 1989, Kaufman et al., 1990, Hutchens et al., 1997)
Not disrupted in	Df(3R)D6 (Cavener et al., 1986) Df(3R)dsx2M (Cavener et al., 1986, Hays et al., 1989, Baker et al., 1991) Df(3R)dsx10M (Cavener et al., 1986) Df(3R)dsx29 (Cavener et al., 1986, Hays et al., 1989) Df(3R)F76 (Cavener et al., 1986) Df(3R)p13 (Hays et al., 1989) Df(3R)p30 (Hays et al., 1989) Df(3R)Scr (Wakimoto et al., 1984, Raff, 1984, Cavener et al., 1986, Hays et al., 1989, Kaufman et al., 1990) Df(3R)Tpl10 (Cavener et al., 1986, Hays et al., 1989) Df(3R)WIN3 (Cavener et al., 1986, Hays et al., 1989)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{UASp-GFPS65C-αTub84B} NA P{UAS-αTub84B.Myc} NA reporter construct P{(TE1)4/hsp/lacZ} No P{DR/UR} No P{DR} No P{hseΔint/lacZ} No P{TE2/TE1} No P{UR} No P{Δint/lacZ} No P{ΔTE1/TE2} No P{ΔTE1} No P{ΔTE2} No P{αTub84B-lacZ(-157/+696)} No P{αTub84B-lacZ(-250/+696)} No P{αTub84B-lacZ(-320/+696)} No P{αTub84B-lacZ(-600/+696)} No P{αTub84B-lacZ(-2000/+696)} No heat-shock construct P{hseΔint/lacZ} NA characterization construct P{5'αTub84B/3'bcd} NA P{AS-α84B} NA P{Mmus\Hoxa2.αTub84B.P} NA P{NC33} NA P{NC33-XH} NA P{rpA1(92)/tub} NA P{rpA1(189)/tub} NA P{rpA1(250)/tub} NA P{tub-RFP.K} NA P{WT-1} NA P{WT-XH} NA P{αTub84B::bcdT:HA1} NA P{αTub84B(FRT.flu-GFP.y+)GAL4.Z} NA P{αTub84B(FRT.Gal80.y+)GAL4.C} NA P{αTub84B(-FRT)GAL4.B} NA P{αTub84B(-FRT)GAL4.Bb} NA P{αTub84B(-FRT)GAL4.C} NA P{αTub84B(-FRT)GAL4.Z} NA P{αTub84B(-FRT)Scer\GAL4.A} NA P{αTub84B+} NA P{αTub84B-Hsap\GLI3} NA P{αTub84B-Hsap\GLI} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{SUPor-P}KG05627 NA insertion of mobile activating element P{EPgy2}αTub84BEY02851 NA
Gene Ontology: Function, Process & Cellular Component ( 16 unique terms )
Terms Based on Experimental Evidence ( 7 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
antimicrobial humoral response inferred from mutant phenotype (Kleino et al., 2005) cellular process inferred from mutant phenotype (Boutros et al., 2004) mitotic cell cycle spindle assembly checkpoint inferred from direct assay (Logarinho et al., 2004) mitotic spindle organization inferred from mutant phenotype (Goshima et al., 2007)
Cellular Component
CV term Evidence References
astral microtubule inferred from direct assay (Hallen et al., 2008) centrosome inferred from direct assay (Hallen et al., 2008) spindle inferred from direct assay (Maiato et al., 2004, Hallen et al., 2008)
Terms Based on Predictions or Assertions ( 9 terms )
Molecular Function
CV term Evidence References
GTPase activity inferred from electronic annotation with InterPro:IPR008280, InterPro:IPR018316 (FlyBase Curators et al., 2004-) GTP binding inferred from electronic annotation with InterPro:IPR000217, InterPro:IPR002452, InterPro:IPR008280, InterPro:IPR017975, InterPro:IPR018316 (FlyBase Curators et al., 2004-) non-traceable author statement (Swiss-Prot Project Members, 1988.1.1) structural constituent of cytoskeleton inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000) structural molecule activity inferred from electronic annotation with InterPro:IPR002452 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
GTP catabolic process inferred from electronic annotation with InterPro:IPR008280, InterPro:IPR018316 (FlyBase Curators et al., 2004-) microtubule-based movement inferred from electronic annotation with InterPro:IPR002452 (FlyBase Curators et al., 2004-) protein polymerization inferred from electronic annotation with InterPro:IPR003008, InterPro:IPR008280, InterPro:IPR018316 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
microtubule inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000) non-traceable author statement (Swiss-Prot Project Members, 1988.1.1) tubulin complex non-traceable author statement (Swiss-Prot Project Members, 1988.1.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions αTub84B allele Gene References αTub84B7.tHa βTub85D (Hays et al., 1989) αTub84B7 βTub85D (Hays et al., 1989, Fuller, 1986) αTub84B7XH βTub85D (Hays et al., 1989) αTub84B+t4.8 βTub85D (Hays et al., 1989) αTub84BXH βTub85D (Hays et al., 1989) unspecified bchs (Simonsen et al., 2007) αTub67C   αTub84D   βTub85D
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 66045 DroID - A comprehensive database of gene and protein interactions. • FBgn0003884 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40848
Orthologs
Genome-wide drosophilid orthologs	Dana\GF17649 Dere\GG13808 Dgri\GH19001 Dsec\GM10931 Dsim\GD19909 Dvir\GJ24568 Dwil\GK12743 Dyak\αTub84B
Curated drosophilid orthologs	Daur\αTub84B   Dbio\αTub84B   Djam\αTub84B   Dpse\GA15128   Dseg\αTub84B   Dser\αTub84B   Dyak\αTub84B
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL013229-PA Aedes aegypti (mosquito) AGAP010971-PA Anopheles gambiae (mosquito) XP_391936.2 Apis mellifera (honey bee) XP_001948685.1 Acyrthosiphon pisum (pea aphid) At1g04820.1 Arabidopsis thaliana (wall cress) At1g50010.1 Arabidopsis thaliana (wall cress) At4g14960.2 Arabidopsis thaliana (wall cress) 36334 Batrachochytrium dendrobatidis (chytrid fungus) 62439 Branchiostoma floridae (lancelet) XP_001893894.1 Brugia malayi (roundworm nematode) BGIBMGA013413-PA Bombyx mori (silk worm) ENSBTAP00000001948 Bos taurus (bovine) ENSBTAP00000038183 Bos taurus (bovine) ENSBTAP00000041398 Bos taurus (bovine) CAL0004511 Candida albicans (a form of yeast) CN03540 Caenorhabditis brenneri (small nematode) CBP37542 Caenorhabditis briggsae (nematode) CE24843 Caenorhabditis elegans (worm) ENSCAFP00000012714 Canis familiaris (dog) CAGL0B02497g Candida glabrata (haploid yeast) Chro.40322 Cryptosporidium hominis (obligate parasite) ENSCINP00000002025 Ciona intestinalis (sea squirt) JA02341 Caenorhabditis japonica (nematode) CMT504C Cyanidioschyzon merolae (red alga) cn02289 Cryptococcus neoformans (yeast-like fungus) cgd4_2860 Cryptosporidium parvum (protozoan parasite) CPIJ017383 Culex pipens (mosquito) CPIJ019940 Culex pipens (mosquito) ENSCPOP00000015949 Cavia porcellus (guinea pig) ENSCPOP00000015975 Cavia porcellus (guinea pig) 128523 Chlamidomonas reinhardtii (green alga) 186023 Chlamidomonas reinhardtii (green alga) RP30765 Caenorhabditis remanei (nematode) ENSCSAVP00000014899 Ciona savignyi (sedentary tunicate) 156933 Capitella spl (polychaete worm) DDB0191380 Dictyostelium discoideum (amoeba) DEHA2A02992g Debaryomyces Hansenii (yeast) 220904 Daphnia pulex (daphnia) ENSDARP00000019888 Danio rerio (zebra fish) ENSECAP00000011664 Equus caballus (horse) XP_653419 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000005312 Gymnopilus aculeatus (mushroom) ENSGALP00000016978 Gallus gallus (chicken) GL50803_103676 Giardia lamblia (flagellated protozoan) GL50803_112079 Giardia lamblia (flagellated protozoan) 185885 Hypsipyla robusta (cedar shoot borer) ENSP00000301071 Homo sapiens (human) ENSP00000326042 Homo sapiens (human) ENSP00000382982 Homo sapiens (human) ISCW003527-PA Ixodes scapularis (deer tick) KLLA0C16874g Kluyveromyces lactis (yeast) 231838 Lottia gigantea (owl limpet) LmjF13.0280 Leishmania major (virus) LmjF13.0290 Leishmania major (virus) LmjF13.0300 Leishmania major (virus) LmjF13.0310 Leishmania major (virus) LmjF13.0320 Leishmania major (virus) LmjF13.0330 Leishmania major (virus) LmjF13.0340 Leishmania major (virus) LmjF13.0350 Leishmania major (virus) LmjF13.0360 Leishmania major (virus) LmjF13.0370 Leishmania major (virus) LmjF13.0380 Leishmania major (virus) LmjF13.0390 Leishmania major (virus) 17634 Monocosta brevicollis (choanoflagellate) ENSMODP00000017907 Monodelphis domestica (gray opossum) ENSMMUP00000008770 Macaca mulatta (rhesus monkey) ENSMUSP00000084713 Mus musculus (house mouse) ENSMUSP00000085580 Mus musculus (house mouse) ENSMUSP00000094778 Mus musculus (house mouse) 182198 Nematostella vectensis (starlet anemone) XP_001607699.1 Nasonia vitripennis (wasp) ENSOANP00000012267 Ornithorynchus anatinus (platypus) ENSORLP00000020467 Oryzias latipes (japanese killifish) LOC_Os11g14220.1 Oryza sativa (asian rice) 8661 Ostreococcus tauri (green alga) PFD1050w Plasmodium falciparum (protozoal parasite) PHUM005392-PA Pediculus humanus (human body louse) PP18942 Pristionchus pacificus (nematode) 211478 Physcomitrella patens (moss) ENSPPYP00000005115 Pongo pygmaeus (orangutan) ENSPPYP00000022337 Pongo pygmaeus (orangutan) 51154 Phytophthora ramorum (sudden oak death pathogen) 71894 Phytophthora ramorum (sudden oak death pathogen) 119319 Phytophthora sojae (root rot pathogen) 707456 Populus trichocarpa (black cottonwood) ENSPTRP00000008374 Pan troglodytes (chimpanzee) ENSPTRP00000021312 Pan troglodytes (chimpanzee) PVX_090155 Plasmodium vivax (protozoal parasite) PVX_098630 Plasmodium vivax (protozoal parasite) ENSRNOP00000006322 Rattus norvegicus (norway rat) 4741542 Sorghum bicolor (sorghum) YML085C Saccharomyces cerevisiae (budding yeast) Smp_090120.1 Schistosoma mansoni (trematode parasite) SPBC16A3.15c Schizosaccharomyces pombe (fission yeast) XP_001178141.1 Strongylocentrotus purpuratus (purple sea urchin) XP_001179181.1 Strongylocentrotus purpuratus (purple sea urchin) 54910 Trichoplax adhaerens (metazoa) TA08335 Theileria annulata (apicomplexan parasite) XP_966492.1 Tribolium castaneum (red flour beetle) Tc00.1047053411235.9 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000001799 Tetraodon nigroviridis (green spotted pufferfish) TP04_0093 Theileria parva (parasitic protozoan) 29304 Thalassiosira pseudonana (marine diatom) ENSTRUP00000000259 Takifugu rubripes (pufferfish Takifugu) ENSTRUP00000020596 Takifugu rubripes (pufferfish Takifugu) ENSTRUP00000023613 Takifugu rubripes (pufferfish Takifugu) ENSTRUP00000031316 Takifugu rubripes (pufferfish Takifugu) 3735.m00096 Tetrahymena thermophila (ciliate protozoa) 86772.m00062 Trichomonas vaginalis (parasitic flagellated protozoan) 87158.m00094 Trichomonas vaginalis (parasitic flagellated protozoan) 90756.m00155 Trichomonas vaginalis (parasitic flagellated protozoan) 92747.m00193 Trichomonas vaginalis (parasitic flagellated protozoan) 92777.m00073 Trichomonas vaginalis (parasitic flagellated protozoan) 95750.m00015 Trichomonas vaginalis (parasitic flagellated protozoan) 96423.m00259 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000024445 Xenopus tropicalis (frog) YALI0E19360g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV13997 NV13665 NV13570 LH20092 LH15949 LH17912 ISCW015260 ISCW003527 FBgn0242028 FBgn0068549 FBgn0216368 FBgn0214752 FBgn0211647 FBgn0191423 FBgn0191393 FBgn0165910 FBgn0165876 JGI_V11_220904 JGI_V11_301837 FBgn0075153 FBgn0150022 FBgn0145784 FBgn0003885 FBgn0129792 FBgn0126468 FBgn0106380 FBgn0106071 FBgn0094667 CPIJ017383 CPIJ011550 CPIJ019940 CPIJ006724 BGIBMGA013413 BGIBMGA002542 BGIBMGA002103 ACYPI010073 ACYPI006761 GB19857 GB10514 AGAP010971 AGAP001218 AGAP001219 AAEL013229 AAEL012101 AAEL006642 PB20645 PHUM304110 PHUM420710 GLEAN_04873 GLEAN_04522
Stocks & Reagents
Stocks Listed in FlyBase ( 19 )
Bloomington	23861 w*; P{UAS-alphaTub84B.Myc}2 32075 w*; P{UASp-PAGFP-alphaTub84B}F11.1 32076 w*; P{UASp-PAGFP-alphaTub84B}F11.4 32177 w*; PBac{GreenEye.UAStubEGFP}Dmel6 32178 w*; PBac{GreenEye.UAStubEGFP}Dmel8 9911 y1 w*; P{UAS-αTub84B.Myc}3 31389 y1 v1; P{TRiP.JF01373}attP2 7373 w*; P{UASp-GFPS65C-αTub84B}3/TM3, Sb1
VDRC	v107109 P{KK108950}VIE-260B v33427 w1118; P{GD9679}v33427 v52345 w1118 P{GD17779}v52345 v52346 w1118 P{GD17779}v52346
	More stocks available...
Genomic Clones ( 2 )
	BACR03E11 BACR03K19 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 1347 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT25469 LD07757 RH71862
Other clones	FI07460 yak-em_alphaTub84B
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT01434 AT01501 AT01572 AT01628 AT02105 AT02293 AT03795 AT04168 AT04402 AT04777 AT04967 AT05338 AT06343 AT06831 AT07289 AT07469 AT07564 AT07987 AT08180 AT08656 AT08837 AT09428 AT09873 AT10929 AT11215 AT11389 AT11571 AT11825 AT12694 AT13094 AT13445 AT13635 AT13854 AT14169 AT14368 AT14727 AT15276 AT15632 AT15640 AT16883 AT17474 AT17551 AT17802 AT17968 AT18047 AT18129 AT18888 AT19024 AT19495 AT19628 AT22864 AT23190 AT24090 AT24514 AT24829 AT25687 AT25865 AT25949 AT26313 AT26510 AT27036 AT27155 AT27245 AT27323 AT28329 AT28860 AT28869 AT29275 AT29488 AT29721 AT31047 AT31895 AT31993 GH01595 GH01726 GH02213 GH06726 GH07328 GH09343 GH22284 GH24551 GH28858 GM02279 GM07087 GM08924 GM09902 GM10011 GM10734 GM22138 GM25378 HL01110 HL01653 HL02390 HL03973 HL04076 HL06674 LD02434 LD03988 LD04102 LD04129 LD05815 LD05971 LD06078 LD06775 LD07031 LD09143 LD10377 LD10506 LD10649 LD11730 LD11793 LD11901 LD12346 LD12541 LD12938 LD13094 LD13588 LD13692 LD15341 LD15764 LD16819 LD17775 LD18027 LD18943 LD18970 LD19313 LD19413 LD19963 LD20380 LD20757 LD21804 LD22219 LD22710 LD22740 LD23095 LD23974 LD24502 LD25857 LD26617 LD26930 LD27417 LD30256 LD30755 LD32351 LD32353 LD33271 LD33406 LD34196 LD35023 LD35101 LD35254 LD36896 LD37016 LD37036 LD37562 LD38518 LD38674 LD39071 LD40260 LD40790 LD43069 LD43832 LD44069 LD45527 LD46560 LP02612 LP02863 LP02975 LP03038 LP05609 LP05954 LP07094 LP07453 LP07885 LP09154 LP10811 LP12925 LP13707 LP15075 LP18394 LP18425 LP18593 LP19615 LP20118 LP20987 LP21447 LP22371 RE12123 RE23358 RE24326 RE37253 RE40267 RE52430 RH10019 RH10362 RH10535 RH17325 RH41566 RH57043 SD03658 SD04635 SD11133 SD21593
Other clones	522877 524454 527962 527963 557048 569210 AT01027 AT01045 AT01077 AT01715 AT02406 AT02437 AT02723 AT03774 AT03775 AT03812 AT04614 AT04736 AT04772 AT04773 AT04959 AT05189 AT05343 AT05504 AT05770 AT06411 AT06446 AT06959 AT07705 AT07724 AT07902 AT08615 AT08981 AT09769 AT10501 AT10920 AT11479 AT12630 AT12843 AT13742 AT14206 AT14852 AT15211 AT15652 AT16080 AT16315 AT16659 AT17491 AT18150 AT18422 AT18517 AT19344 AT20091 AT20592 AT21264 AT21855 AT23066 AT23095 AT23251 AT23508 AT23712 AT24848 AT24859 AT27281 AT28025 AT29245 AT29304 AT29750 AT29795 AT30308 AT30352 AT30358 AT30657 AT31085 AT31302 bs15a03 bs37f01 bs40d03 bs45c07 bs48h09 bs50d07 bs62b04 bs67a04 bs68b06 bs74g09 bs74g10 bs75d05 bs82c01 bs82h07 Dmel_dig_001678_0692_0346 Dmel_dig_002517_0641_1944 Dmel_dig_002834_0699_1550 Dmel_dig_005477_0705_1549 Dmel_dig_006138_0636_2085 Dmel_dig_008458_0716_0915 Dmel_dig_008616_0635_2495 Dmel_dig_011056_0648_1577 Dmel_dig_011645_0669_0678 Dmel_dig_012188_0695_0555 Dmel_dig_014027_0640_1096 Dmel_dig_014826_0677_0757 Dmel_dig_015602_0645_3347 Dmel_dig_017862_0640_1196 Dmel_dig_017898_0605_2745 Dmel_dig_020007_0694_0470 Dmel_neb_001176_0331_3690 Dmel_neb_005525_0622_3593 Dmel_neb_008186_0344_2796 Dmel_neb_008964_0687_0652 Dmel_neb_009626_0379_1633 Dmel_neb_013069_0157_0918 Dmel_neb_013152_0331_2740 Dmel_neb_013267_0576_1905 Dmel_neb_013579_0638_0656 Dmel_neb_013892_0195_1965 Dmel_neb_014950_0336_2742 EC25408 EC39206 EC39593 EC051363 EK010616 EK090134 EK132003 EK136701 EK180801 EK184018 EK204411 EK208115 EK225645 EK250146 EK253650 EK255654 EK268828 EK304558 EN00205 EN01535 EN02749 EN02942 EN03030 EN03144 EN03157 EN03330 EN03517 EN05426 EN05460 EN06530 EN07450 EN08135 EN08137 EN09322 EN09524 EN09614 EN10214 EN10715 EN11022 EN11929 EN12031 EN12315 EN12338 EN12512 EN12812 EN13017 EN13208 EN14741 EN14930 EN14942 EN15358 EN16305 EN17457 ESG017b.E21_F05 ESG018a.E21_B10 FGM209G07 FGM232C01 GH01316 GH01455 GH01943 GH02939 GH02983 GH03189 GH03210 GH04743 GH06081 GH06867 GH06967 GH07538 GH08087 GH08281 GH08768 GH08953 GH09128 GH09325 GH09613 GH09736 GH09880 GH09933 GH10203 GH10693 GH11347 GH11462 GH11505 GH12085 GH12355 GH12922 GH14763 GH14818 GH15059 GH15420 GH15492 GH15715 GH16208 GH17380 GH17606 GH18179 GH18228 GH18440 GH18526 GH18639 GH18724 GH19136 GH19919 GH19991 GH20516 GH21051 GH21912 GH22040 GH23304 GH23959 GH23974 GH24751 GH24946 GH26905 GH27626 GH27748 GH27979 GH28562 GH28818 GM01525 GM01589 GM01665 GM01781 GM01903 GM01988 GM02073 GM02074 GM02352 GM03737 GM04222 GM04230 GM04241 GM04765 GM04904 GM05039 GM05513 GM05547 GM06115 GM06222 GM06569 GM08063 GM08344 GM08459 GM08828 GM09190 GM10454 GM10544 GM12409 GM12421 GM12434 GM12564 GM12731 GM13791 GM14649 GM15365 GM15463 GM15481 GM15866 GM16186 GM16268 GM16312 GM17088 GM17549 GM17622 GM18942 GM18991 GM19079 GM20995 GM21086 GM21273 GM21326 GM22627 GM22735 GM23080 GM23310 GM23572 GM23937 GM26361 GM26656 GM28767 GM29018 GM29142 GM29455 GM29712 GM30550 GM30749 GM31563 HL01783 HL02619 HL03891 HL03908 HL05468 HL05470 HL06193 HL08005 IP06537 IP06637 IP06737 IP12002 LD01114 LD01316 LD01385 LD01393 LD01496 LD01616 LD01618 LD01770 LD02014 LD02108 LD02111 LD02246 LD02502 LD02517 LD02535 LD02691 LD02867 LD02868 LD02935 LD02943 LD02984 LD03149 LD03336 LD03338 LD03510 LD03542 LD03667 LD03685 LD03780 LD04130 LD04163 LD04222 LD04359 LD04458 LD04575 LD04622 LD04664 LD04943 LD05067 LD05071 LD05165 LD05262 LD05411 LD05554 LD05601 LD05804 LD06004 LD06027 LD06273 LD06295 LD06562 LD06582 LD06621 LD06719 LD06722 LD06757 LD06905 LD06939 LD06995 LD07186 LD07205 LD07217 LD07480 LD07603 LD07712 LD07736 LD07928 LD08030 LD08065 LD08222 LD08433 LD08460 LD08538 LD08742 LD08840 LD08957 LD09015 LD09091 LD09362 LD09388 LD09548 LD10175 LD10686 LD10734 LD10738 LD10742 LD11012 LD11274 LD11532 LD11669 LD11704 LD11928 LD12047 LD12092 LD12252 LD12515 LD12704 LD12995 LD13020 LD13101 LD13185 LD13404 LD13432 LD13456 LD13617 LD13868 LD14074 LD14108 LD14205 LD14567 LD14668 LD14832 LD14914 LD15191 LD15260 LD15889 LD16870 LD16895 LD16945 LD17043 LD18045 LD18110 LD18167 LD18973 LD19142 LD19707 LD19777 LD19781 LD19892 LD19994 LD20214 LD20312 LD20533 LD20650 LD20673 LD20730 LD20731 LD20771 LD21291 LD21303 LD21340 LD21464 LD21473 LD21487 LD21644 LD21653 LD21710 LD21752 LD21967 LD22016 LD22254 LD22277 LD22314 LD22352 LD22383 LD22402 LD22424 LD22522 LD22912 LD23026 LD23232 LD23280 LD23289 LD23330 LD23350 LD23354 LD23406 LD23707 LD23780 LD23792 LD23840 LD23855 LD23905 LD23970 LD24015 LD24130 LD24138 LD24175 LD24211 LD24224 LD24320 LD24361 LD24390 LD24433 LD24564 LD24619 LD24644 LD24648 LD24719 LD24733 LD24760 LD25011 LD25162 LD25370 LD25447 LD25562 LD25580 LD25594 LD25661 LD25676 LD25724 LD25763 LD25851 LD25945 LD26332 LD26523 LD26559 LD26717 LD26926 LD26955 LD27046 LD27077 LD27079 LD27239 LD27284 LD27380 LD27403 LD27418 LD28018 LD28171 LD28269 LD28514 LD28577 LD28621 LD28705 LD28768 LD28945 LD29001 LD29102 LD29107 LD29188 LD29340 LD29403 LD29451 LD29547 LD29563 LD29646 LD29676 LD29691 LD29873 LD29943 LD30120 LD30193 LD30310 LD30756 LD30906 LD31305 LD31338 LD31446 LD31468 LD31568 LD31666 LD31807 LD31883 LD32074 LD32165 LD32193 LD32264 LD32278 LD32302 LD32507 LD32676 LD32715 LD32924 LD33161 LD33302 LD33391 LD33434 LD33557 LD33655 LD33835 LD33933 LD34249 LD34261 LD34306 LD34353 LD34627 LD34680 LD34904 LD34938 LD35014 LD35106 LD35127 LD35183 LD35276 LD35439 LD35446 LD35477 LD35531 LD35549 LD35573 LD35774 LD35856 LD35958 LD36027 LD36285 LD36470 LD36471 LD36537 LD36596 LD36640 LD36693 LD36702 LD36758 LD36860 LD36893 LD36917 LD36929 LD37047 LD37224 LD37331 LD37622 LD37642 LD37725 LD37854 LD37881 LD37895 LD37929 LD38008 LD38034 LD38126 LD38141 LD38279 LD38330 LD38338 LD38345 LD38528 LD38570 LD38701 LD38761 LD38834 LD38923 LD38947 LD38966 LD39146 LD39214 LD39267 LD39322 LD39443 LD39533 LD39651 LD39786 LD39827 LD39907 LD39960 LD40084 LD40111 LD40184 LD40218 LD40219 LD40569 LD40771 LD40780 LD40827 LD40939 LD41024 LD41044 LD41473 LD41521 LD41573 LD41620 LD41655 LD41819 LD41875 LD42391 LD42509 LD42516 LD42786 LD42902 LD43105 LD43124 LD43128 LD43148 LD43162 LD43339 LD43452 LD43577 LD43639 LD43931 LD44002 LD44181 LD44287 LD44380 LD44390 LD44476 LD44781 LD44932 LD45109 LD45136 LD45175 LD45189 LD45241 LD45470 LD45545 LD45642 LD45739 LD45807 LD45975 LD46379 LD46471 LD46514 LD46637 LD46874 LD47026 LD47219 LD47260 LD47290 LD47501 LD47531 LD47546 LD47834 LD47892 LD48025 LD48055 LD48075 LP01169 LP01783 LP02077 LP02625 LP02702 LP02825 LP03386 LP03465 LP03703 LP03727 LP03812 LP04074 LP04886 LP05254 LP05684 LP05907 LP05980 LP06223 LP06244 LP06750 LP07148 LP07319 LP07379 LP07764 LP07889 LP07993 LP08290 LP08304 LP08382 LP08384 LP08611 LP08625 LP08715 LP09083 LP09156 LP09639 LP09669 LP09735 LP09912 LP09986 LP10210 LP10281 LP11287 LP11340 LP11950 LP12233 LP12844 LP12954 LP13164 LP13379 LP13809 LP14290 LP14626 LP15204 LP15422 LP15781 LP15920 LP16149 LP16170 LP16511 LP16775 LP16927 LP16935 LP17124 LP17478 LP17677 LP17889 LP17960 LP18339 LP18546 LP18645 LP18760 LP18876 LP19110 LP19382 LP19601 LP19765 LP19784 LP20084 LP20207 LP20255 LP20781 LP20846 LP21272 LP21291 LP21415 LP21417 LP21805 LP21912 LP22233 LP23268 LP23596 LP23609 LP24186 LP24266 LP24306 RC0-DA0001-120700-016-H04 RC0-DL0001-140700-015-A06 RE01487 RE02856 RE03652 RE03844 RE03962 RE03974 RE05448 RE05489 RE05927 RE06079 RE06138 RE06418 RE06463 RE06573 RE06830 RE06894 RE07724 RE11377 RE12111 RE12543 RE12843 RE13106 RE13856 RE14531 RE14902 RE15036 RE16480 RE16733 RE17950 RE18208 RE18272 RE18741 RE20770 RE21156 RE21926 RE22249 RE22404 RE22483 RE22835 RE22896 RE22938 RE22953 RE24406 RE24483 RE24488 RE25108 RE25275 RE25301 RE25439 RE25521 RE25717 RE26114 RE26615 RE26871 RE27057 RE27206 RE27233 RE27480 RE28405 RE28566 RE29333 RE29602 RE30114 RE30706 RE30968 RE31006 RE32051 RE32243 RE32419 RE32845 RE33237 RE34016 RE34063 RE35272 RE35989 RE36322 RE36369 RE36658 RE36680 RE36753 RE36759 RE37344 RE37652 RE37731 RE38603 RE39248 RE39502 RE41315 RE41455 RE42694 RE42731 RE42905 RE43636 RE45221 RE45854 RE46987 RE47275 RE47445 RE47480 RE47560 RE47838 RE48240 RE49484 RE49628 RE49887 RE49916 RE50090 RE51384 RE52020 RE52731 RE53757 RE54825 RE55547 RE55628 RE55965 RE56446 RE57940 RE59302 RE59986 RE60562 RE60868 RE61078 RE61474 RE61478 RE61547 RE61763 RE62163 RE62377 RE62619 RE62977 RE63586 RE63694 RE63781 RE63808 RE64382 RE65082 RE66637 RE67338 RE68133 RE68172 RE70025 RE70110 RE70666 RE70707 RE70744 RE73424 RE74083 RE74396 RH01031 RH04184 RH04339 RH04842 RH04885 RH04889 RH04927 RH05319 RH05479 RH05535 RH05544 RH05866 RH06181 RH06194 RH07065 RH07176 RH07456 RH07768 RH07916 RH08179 RH08333 RH08737 RH08816 RH09940 RH10565 RH11803 RH17439 RH19255 RH20180 RH21457 RH21519 RH21614 RH22625 RH23707 RH23769 RH26790 RH27225 RH27243 RH28882 RH29274 RH29622 RH30026 RH30136 RH32527 RH32642 RH33487 RH35481 RH36067 RH36113 RH36408 RH36735 RH37652 RH38234 RH38451 RH38670 RH39458 RH40805 RH42595 RH42817 RH43224 RH43302 RH44580 RH46640 RH46735 RH46841 RH47256 RH47293 RH48233 RH49946 RH49977 RH50154 RH51104 RH51162 RH51568 RH51691 RH51709 RH52304 RH52505 RH53724 RH53790 RH54103 RH55463 RH58129 RH58251 RH58407 RH59371 RH61391 RH61629 RH62304 RH62321 RH63147 RH63487 RH64295 RH71041 RH71104 RH73140 RH73946 SD03056 SD04433 SD04761 SD05116 SD05974 SD06887 SD07150 SD07419 SD08248 SD09425 SD09730 SD09920 SD10373 SD11521 SD12585 SD12754 SD12881 SD12882 SD13194 SD13534 SD13733 SD13957 SD14188 SD14368 SD14422 SD14802 SD14826 SD14862 SD15222 SD15305 SD15758 SD15769 SD16184 SD16191 SD16417 SD16552 SD17261 SD17603 SD18264 SD18657 SD20788 SD21321 SD21368 SD21482 SD22263 SD22317 SD22716 SD22825 SD23485 SD23963 SD24050 SD24515 SD26372 SD26392 SD26521 SD27102 SD27145 SD27996 UT01184 UT01287 UT01417 UT01736 UT01803 UT01960 UUGC0668
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0003884 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40848
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: αTub84B CG1913 (Li, 1999.11)
Source for database merge of	Source for merge of: αTub84B BEST:LD32507 (Rana, 2004.7.8)
Additional comments
Other Comments
	RNAi screen using dsRNA made from templates generated with primers directed against this gene in S2 cell results in dim staining of microtubules, and a short monopolar spindle. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA. (Goshima et al., 2007) RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a greater than three-fold increase in AttA activity in response to heat-killed E.coli after ecdysone treatment in S2 cells. (Kleino et al., 2005) RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells. (Boutros et al., 2004) RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells. (Boutros et al., 2004) In a sample of 79 genes with multiple introns, 33 showed significant heterogeneity in G+C content among introns of the same gene and significant positive correspondence between the intron and the third codon position G+C content within genes. These results are consistent with selection adding against preferred codons at the start of genes. (Kliman and Eyre-Walker, 1998) Though αTub84B and αTub85E are very similar in sequence they are functionally distinct. αTub85E can provide function in the male germ line of generic microtubule arrays but lacks a subset of the functional properties possessed by specific features of microtubule assembly unique to the male germ cells. (Hutchens et al., 1997) αTub84B staining is used to analyse microtubule configuration during the first division of the zygote to investigate the organisation of the first cleavage spindle and the origin of the functional centrosome. (Callaini and Riparbelli, 1996) Mixtures of ncd or Khc motor domain treated with the zero-length cross linker EDC generates covalently cross linked products of ncd or Khc with βTub56D and αTub84B. These results indicate that kinesin family motors of opposite polarity interact with both βTub56D and αTub84B and support a model in which some portion of each ncd or Khc proteins motor domain overlaps adjacent βTub56D and αTub84B subunits. (Walker, 1995) Two upstream regions, tubulin element 1 (TE1) and tubulin element 2 (TE2), and an intron activate expression of αTub84B. These regions act ubiquitously to insulate from position effects and to activate transcription. (O'Donnell et al., 1994) Investigation of the proteins that bind the regulatory sequences of αTub84B. DNaseI footprinting assays demonstrate Trl binds to tubulin element 2 (TE2) and the intron of αTub84B, but not to tubulin element 1 (TE1) and Tbf1 binds to tubulin element 1 (TE1) and tubulin element 2 (TE2) of αTub84B. (O'Donnell and Wensink, 1994) Both meiosis and cleavage stage mitoses are severely affected by mutations that result in a substantial decrease in the αTub67C/αTub84B+αTub84D ratio, though an increase has little effect on meiosis while still disrupting mitotic spindle formation. (Matthews et al., 1993) Total α-tubulin levels remain high throughout embryogenesis. Constitutive isotypes are more stable than maternal isotypes in most tissues. (Theurkauf, 1992) Apical localization of pair-rule transcripts restricts lateral protein diffusion allowing pair-rule proteins to define sharp boundaries and precise spatial domains. (Davis and Ish-Horowicz, 1991) An allele of αTub84B has been identified due to second site non-complementation of alleles (including a null allele) of βTub85D, though a deletion for αTub84B complements βTub85Dn. The genetic interaction between βTub85D and αTub84B is based on the structural interaction between the protein products of each gene. (Hays et al., 1989) The expression of βTub60D is accompanied by a coordinate transient increase in the level of synthesis of the embryonic α-tubulins, thereby maintaining an approximately equimolar synthesis of α- and β-tubulins throughout embryogenesis. (Raff et al., 1982) In D.melanogaster, two multigene families, each made up of four members, code for α- and β-tubulins. Tubulins are a highly conserved family of proteins that are the main structural components of microtubules in mitotic and meiotic spindles, cilia, flagella, neural processes and the cytoskeleton; nontubulin proteins (MAPS or microtubule-associated proteins) are involved along with tubulins in the formation of specialized microtubules (FBrf0045282; FBrf0046966). Transcribed in the oocyte and the embryo, reaching a maximum level 6-9 hr after the egg is laid (FBrf0037623). A variety of post-translational modifications of αTub84B protein found in all tissues, some of which are tissue-specific (FBrf0049502). The gene appears to be constitutively expressed, its functions being common to most cells. Maternal-effect as well as zygotic lethality is shown by the more severe alleles. In the less severe hypomorphic alleles, heterozygotes die late in pupal life or early in adult life, the adults showing head, thoracic, or abdominal defects, bristle abnormalities, leg tremors and sterility (FBrf0046004). Both meiosis and cleavage stage mitoses are severely affected by mutations that result in a substantial decrease in the αTub67C/αTub84B+αTub84D ratio, though an increase has little effect on meiosis while still disrupting mitotic spindle formation (FBrf0058107). Missense mutations may be male sterile when doubly heterozygous with missense allele of βTub85D (FBrf0050548).
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057424 RefSeq (Proteins) • NP_476772 DDBJ / EMBL / GenBank • AA202354 AA951786 AAA28985 AAF54067 AC004266 AC008225 AI124284 AI124313 M14643 Entrez Gene - A searchable database of RefSeq genes. • 40848 UniProtKB/Swiss-Prot • P06603
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Tubulin (IPR000217) Alpha tubulin (IPR002452) Tubulin/FtsZ, GTPase domain (IPR003008) Tubulin/FtsZ, C-terminal (IPR008280) Tubulin, conserved site (IPR017975) Tubulin/FtsZ, 2-layer sandwich domain (IPR018316) Tubulin, C-terminal (IPR023123)
Linkouts
	BioGRID - A database of protein and genetic interactions • 66045 DroID - A comprehensive database of gene and protein interactions. • FBgn0003884 DRSC - Results from RNAi screens. • FBgn0003884 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003884 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1913-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0003884 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40848 InParanoid A subset of ortholog calls from InParanoid. • AAEL013229-PA Aedes aegypti (mosquito) AGAP010971-PA Anopheles gambiae (mosquito) XP_391936.2 Apis mellifera (honey bee) XP_001948685.1 Acyrthosiphon pisum (pea aphid) At1g04820.1 Arabidopsis thaliana (wall cress) At1g50010.1 Arabidopsis thaliana (wall cress) At4g14960.2 Arabidopsis thaliana (wall cress) 36334 Batrachochytrium dendrobatidis (chytrid fungus) 62439 Branchiostoma floridae (lancelet) XP_001893894.1 Brugia malayi (roundworm nematode) BGIBMGA013413-PA Bombyx mori (silk worm) ENSBTAP00000001948 Bos taurus (bovine) ENSBTAP00000038183 Bos taurus (bovine) ENSBTAP00000041398 Bos taurus (bovine) CAL0004511 Candida albicans (a form of yeast) CN03540 Caenorhabditis brenneri (small nematode) CBP37542 Caenorhabditis briggsae (nematode) CE24843 Caenorhabditis elegans (worm) ENSCAFP00000012714 Canis familiaris (dog) CAGL0B02497g Candida glabrata (haploid yeast) Chro.40322 Cryptosporidium hominis (obligate parasite) ENSCINP00000002025 Ciona intestinalis (sea squirt) JA02341 Caenorhabditis japonica (nematode) CMT504C Cyanidioschyzon merolae (red alga) cn02289 Cryptococcus neoformans (yeast-like fungus) cgd4_2860 Cryptosporidium parvum (protozoan parasite) CPIJ017383 Culex pipens (mosquito) CPIJ019940 Culex pipens (mosquito) ENSCPOP00000015949 Cavia porcellus (guinea pig) ENSCPOP00000015975 Cavia porcellus (guinea pig) 128523 Chlamidomonas reinhardtii (green alga) 186023 Chlamidomonas reinhardtii (green alga) RP30765 Caenorhabditis remanei (nematode) ENSCSAVP00000014899 Ciona savignyi (sedentary tunicate) 156933 Capitella spl (polychaete worm) DDB0191380 Dictyostelium discoideum (amoeba) DEHA2A02992g Debaryomyces Hansenii (yeast) 220904 Daphnia pulex (daphnia) ENSDARP00000019888 Danio rerio (zebra fish) ENSECAP00000011664 Equus caballus (horse) XP_653419 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000005312 Gymnopilus aculeatus (mushroom) ENSGALP00000016978 Gallus gallus (chicken) GL50803_103676 Giardia lamblia (flagellated protozoan) GL50803_112079 Giardia lamblia (flagellated protozoan) 185885 Hypsipyla robusta (cedar shoot borer) ENSP00000301071 Homo sapiens (human) ENSP00000326042 Homo sapiens (human) ENSP00000382982 Homo sapiens (human) ISCW003527-PA Ixodes scapularis (deer tick) KLLA0C16874g Kluyveromyces lactis (yeast) 231838 Lottia gigantea (owl limpet) LmjF13.0280 Leishmania major (virus) LmjF13.0290 Leishmania major (virus) LmjF13.0300 Leishmania major (virus) LmjF13.0310 Leishmania major (virus) LmjF13.0320 Leishmania major (virus) LmjF13.0330 Leishmania major (virus) LmjF13.0340 Leishmania major (virus) LmjF13.0350 Leishmania major (virus) LmjF13.0360 Leishmania major (virus) LmjF13.0370 Leishmania major (virus) LmjF13.0380 Leishmania major (virus) LmjF13.0390 Leishmania major (virus) 17634 Monocosta brevicollis (choanoflagellate) ENSMODP00000017907 Monodelphis domestica (gray opossum) ENSMMUP00000008770 Macaca mulatta (rhesus monkey) ENSMUSP00000084713 Mus musculus (house mouse) ENSMUSP00000085580 Mus musculus (house mouse) ENSMUSP00000094778 Mus musculus (house mouse) 182198 Nematostella vectensis (starlet anemone) XP_001607699.1 Nasonia vitripennis (wasp) ENSOANP00000012267 Ornithorynchus anatinus (platypus) ENSORLP00000020467 Oryzias latipes (japanese killifish) LOC_Os11g14220.1 Oryza sativa (asian rice) 8661 Ostreococcus tauri (green alga) PFD1050w Plasmodium falciparum (protozoal parasite) PHUM005392-PA Pediculus humanus (human body louse) PP18942 Pristionchus pacificus (nematode) 211478 Physcomitrella patens (moss) ENSPPYP00000005115 Pongo pygmaeus (orangutan) ENSPPYP00000022337 Pongo pygmaeus (orangutan) 51154 Phytophthora ramorum (sudden oak death pathogen) 71894 Phytophthora ramorum (sudden oak death pathogen) 119319 Phytophthora sojae (root rot pathogen) 707456 Populus trichocarpa (black cottonwood) ENSPTRP00000008374 Pan troglodytes (chimpanzee) ENSPTRP00000021312 Pan troglodytes (chimpanzee) PVX_090155 Plasmodium vivax (protozoal parasite) PVX_098630 Plasmodium vivax (protozoal parasite) ENSRNOP00000006322 Rattus norvegicus (norway rat) 4741542 Sorghum bicolor (sorghum) YML085C Saccharomyces cerevisiae (budding yeast) Smp_090120.1 Schistosoma mansoni (trematode parasite) SPBC16A3.15c Schizosaccharomyces pombe (fission yeast) XP_001178141.1 Strongylocentrotus purpuratus (purple sea urchin) XP_001179181.1 Strongylocentrotus purpuratus (purple sea urchin) 54910 Trichoplax adhaerens (metazoa) TA08335 Theileria annulata (apicomplexan parasite) XP_966492.1 Tribolium castaneum (red flour beetle) Tc00.1047053411235.9 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000001799 Tetraodon nigroviridis (green spotted pufferfish) TP04_0093 Theileria parva (parasitic protozoan) 29304 Thalassiosira pseudonana (marine diatom) ENSTRUP00000000259 Takifugu rubripes (pufferfish Takifugu) ENSTRUP00000020596 Takifugu rubripes (pufferfish Takifugu) ENSTRUP00000023613 Takifugu rubripes (pufferfish Takifugu) ENSTRUP00000031316 Takifugu rubripes (pufferfish Takifugu) 3735.m00096 Tetrahymena thermophila (ciliate protozoa) 86772.m00062 Trichomonas vaginalis (parasitic flagellated protozoan) 87158.m00094 Trichomonas vaginalis (parasitic flagellated protozoan) 90756.m00155 Trichomonas vaginalis (parasitic flagellated protozoan) 92747.m00193 Trichomonas vaginalis (parasitic flagellated protozoan) 92777.m00073 Trichomonas vaginalis (parasitic flagellated protozoan) 95750.m00015 Trichomonas vaginalis (parasitic flagellated protozoan) 96423.m00259 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000024445 Xenopus tropicalis (frog) YALI0E19360g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40848 modMine - Data generated by the modENCODE project. • FBgn0003884 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV13997 NV13665 NV13570 LH20092 LH15949 LH17912 ISCW015260 ISCW003527 FBgn0242028 FBgn0068549 FBgn0216368 FBgn0214752 FBgn0211647 FBgn0191423 FBgn0191393 FBgn0165910 FBgn0165876 JGI_V11_220904 JGI_V11_301837 FBgn0075153 FBgn0150022 FBgn0145784 FBgn0003885 FBgn0129792 FBgn0126468 FBgn0106380 FBgn0106071 FBgn0094667 CPIJ017383 CPIJ011550 CPIJ019940 CPIJ006724 BGIBMGA013413 BGIBMGA002542 BGIBMGA002103 ACYPI010073 ACYPI006761 GB19857 GB10514 AGAP010971 AGAP001218 AGAP001219 AAEL013229 AAEL012101 AAEL006642 PB20645 PHUM304110 PHUM420710 GLEAN_04873 GLEAN_04522 REDfly - A database of transcriptional regulatory elements. • FBgn0003884
Synonyms & Secondary IDs ( 72 )
Reported As
Symbol Synonym	1t (Fyrberg and Goldstein, 1990) a1t (Fuller, 1993) ALPHA 84C (Goldstein and Gunawardena, 2000) alphaTub84B (Liu et al., 2008, Giot et al., 2003, Richardson and Pichaud, 2007, Luo, 2007.3.23, Dorus et al., 2006, Januschke et al., 2006, Holtzman et al., 2010, Wasbrough et al., 2010, Wasbrough et al., 2010, Abreu-Blanco et al., 2011) alpha-tub84B (Findlay et al., 2009) anon-EST:Liang-1.59   anon-EST:Liang-2.30   aTub84B (Kliman and Eyre-Walker, 1998) a-tub84B (Alves-Silva et al., 2008) BEST:LD32507   CG1913 (Fulton et al., 2001, Goldstein and Gunawardena, 2000, Goshima et al., 2007, Pisa et al., 2009, Keleman et al., 2009.8.5, Wertheim et al., 2005, Ni et al., 2008, Ling and Salvaterra, 2011, Ponton et al., 2011, Cammarato et al., 2011) clone 1.59 (Liang and Biggin, 1998) clone 2.30 (Liang and Biggin, 1998) DM1α (Gunawardane et al., 2000, M Mahoney, 2006) DTA1 (Natzle and McCarthy, 1984) l(3)84Bd   l(3)g3   ms(3)nc33   nc33 (Fuller, 1986) T (Courgeon et al., 1993) Tub (Wei et al., 2004, Harris and Peifer, 2004, Martins et al., 2009) tub (Lee et al., 2009, Iijima-Ando et al., 2009) Tuba84B (Maroni, 1994) tubA84B (Ripoll et al., 1987, ) tubulin (Oshima, 2006) Tubα1 (Nellen et al., 1996, Dubnau and Struhl, 1996) tubα1 (Landsberg et al., 2009) Tα1 (Harrison and Perrimon, 1993) α1 (Drosopoulou and Scouras, 1998, Walker, 1995) α1t (O'Donnell et al., 1994, Green et al., 1990, ) α1tub (Liu et al., 2000) α1tub84B (Abuin et al., 2011) α84B (Raff, 1984, Popodi et al., 2008, Hoyle et al., 2008, Popodi et al., 2008) αT (Wakimoto et al., 1984) αt-1 (Patel and Jacobs-Lorena, 1992) α-Tub (Ruel et al., 2003, de Carcer et al., 2001, Wang et al., 2007, Fichelson et al., 2010, Ardehali et al., 2011) αTUB (Herzig et al., 2002) αTub (Kaufman et al., 1990, Cavener et al., 1986, Wehr et al., 2006, Delanoue and Davis, 2005, Audibert et al., 2005) αtub (Siegrist and Doe, 2005) α-tub (Li et al., 2001) αTub1   αTub84 (Tortoriello et al., 2009) α-Tub84B (Doheny et al., 2008, Rebollo et al., 2009) αTub84B (Maiato et al., 2005, Serbus et al., 2005, Luo, 2007.7.24, Verdier et al., 2006, Stuart et al., 2007, Goshima et al., 2007, White et al., 2011, Walser et al., 2006, Murray and Saint, 2007, Takemori and Yamamoto, 2009, Weake et al., 2011, Pisa et al., 2009, Dorus et al., 2006, Venken et al., 2009, Ling and Salvaterra, 2011, Cherbas et al., 2011) αtub84B (Rebollo et al., 2004) α-tubulin (Martinez-Campos et al., 2004, Wasser and Chia, 2003, Maiato et al., 2006)
Name Synonym	actin (Hickson et al., 2006) alpha-tubulin (Silva et al., 2004, Przewloka et al., 2007) Alpha tubulin (Ling and Salvaterra, 2011) alpha-tubulin 84B (Sun et al., 2011) alpha-Tubulin at 84B (Wasbrough et al., 2010, Cammarato et al., 2011) tubulin (Goshima et al., 2007, Sharp et al., 2000, Reed and Orr-Weaver, 1997, Mahoney et al., 2006, Harris and Peifer, 2004, Slep et al., 2005, Galindo et al., 2007, Harris and Peifer, 2005, Goshima et al., 2005, Schneider et al., 2006, Frescas et al., 2006, Ashley et al., 2005, Shimada et al., 2006, Leiss et al., 2009, Alves-Silva et al., 2008, Lee et al., 2009, Yuen et al., 2008, Iijima-Ando et al., 2009, Wang et al., 2010, Puah et al., 2011) Tubulin (Rikhy et al., 2007, Ataman et al., 2006, Ataman, 2006, Ponton et al., 2011) tubulin 1α (Lee and Luo, 1999) tubulin1α (Bardet et al., 2008) Tubulin 1 α-chain (de Morais Guedes et al., 2003) tubulin84B (Jana et al., 2011) tubulin alpha1 promoter (Bardet et al., 2008) tubulin α1 (Lee and Kolodziej, 2002) Tubulin-α1 (Heberlein et al., 1995, Ahrens et al., 2007) α1-tubulin (Lehmann, 2004, Surdej and Jacobs-Lorena, 1998, Wilkins and Lis, 1997, Breitwieser et al., 1996, Granok et al., 1995, Angelichio et al., 1991, O'Donnell and Wensink, 1994, Venkei et al., 2006) α1 tubulin (Raff et al., 1982) α1-tubulin (Ashraf et al., 2006) α1 tubulin (Ashraf et al., 2006) αT (Galindo et al., 2007) α-Tubulin (Wei et al., 2004, Betschinger et al., 2005, Albertson and Doe, 2003, Berdnik and Knoblich, 2002, van Steensel et al., 2001, Huynh et al., 2001, Bhat et al., 1996, Trotta et al., 2004, Brandt et al., 2006, Basto et al., 2006, Szafranski and Goode, 2007, Schulte et al., 2010, Fichelson et al., 2010) α-tubulin (Mendjan et al., 2006, Verollet et al., 2006, Neisch et al., 2005, Kwon and Scholey, 2004, Cottam et al., 2004, Fuse et al., 2003, Betschinger et al., 2003, Mathe et al., 2003, Mollinari et al., 2002, Sampaio et al., 2001, Bellaiche et al., 2001, Wakefield et al., 2001, Stevenson et al., 2001, Walker et al., 2000, Loppin et al., 2001, Ben-Yaacov et al., 2001, Leismann et al., 2000, Roos et al., 2000, Lemos et al., 2000, Lange et al., 2000, Brent et al., 2000, Sibon et al., 2000, Moutinho-Santos et al., 1999, Swan et al., 1999, Wilson, 1999, Wilson, 1999, Gho et al., 1999, Cullen et al., 1999, Yu and Bienz, 1999, Megraw et al., 1999, Larkin et al., 1999, Herrmann et al., 1998, Kuchinke et al., 1998, Endow and Komma, 1998, Helps et al., 1998, Eaton et al., 1996, Li and Kaufman, 1996, Johansen et al., 1995, Brill et al., 1995, Endow et al., 1994, Callaini et al., 1994, Baker et al., 1993, Yasuda et al., 1991, Bendena et al., 1991, Wu et al., 1990, Moon and Hazelrigg, 2004, Logarinho et al., 2004, Cook et al., 2004, Somma et al., 2003, Lee et al., 2003, Roper and Brown, 2004, Callaini and Riparbelli, 1996, Yu et al., 2006, Wilson, 2005, Maiato et al., 2004, McHugh et al., 2004, Hawley and Gilliland, 2006, Murray and Saint, 2007, Ohlstein and Spradling, 2007, Rujano et al., 2006, Griffis et al., 2007, Sakaguchi and Steward, 2007, Meignin et al., 2004, Cullen et al., 2005, Murakami et al., 2007, Rodrigues-Martins et al., 2007, Savoian and Rieder, 2002, Fei et al., 2002, Cheng et al., 2008, Holtzman et al., 2008, Staudt et al., 2006, Gao et al., 2008, Wang et al., 2007, Silverman-Gavrila et al., 2008, Rebollo et al., 2007, Pandey et al., 2007, Zhang et al., 2009, Liang et al., 2009, Colombié et al., 2008, Kner et al., 2009, Dyer et al., 2007, Li et al., 2001, Brandt, 2006, Bucciarelli et al., 2009, Popodi et al., 2008, Hoyle et al., 2008, Popodi et al., 2008, Hallen et al., 2008, MacDonald et al., 2006, Hughes et al., 2011) α tubulin (Donaldson et al., 2001, Audibert and Simonelig, 1999, Nicolai et al., 1999, Avides and Glover, 1999, Bonaccorsi et al., 1998, Riparbelli et al., 1997, Stumpff et al., 2004, Doerflinger et al., 2003, Abdu et al., 2006) αtubulin (Grieder and Spradling, 1999, Craig and Brink, 1996) αTubulin84B (Bokel et al., 2005) α-tubulin84B (Simonsen et al., 2007) α tubulin 84B (Dean et al., 2005) α-Tubulin84B (Murray and Saint, 2007) α-Tubulin 84B (Pisa et al., 2009) α-Tubulin at 84B (Takemori and Yamamoto, 2009, Robinson et al., 2010)
Secondary FlyBase IDs
	FBgn0046254
References ( 375 )
Generate a list of	All references relating to this gene ( 375 )
List References by type	Research paper  ( 308 ) Supplementary material  ( 21 ) Review  ( 16 ) Erratum  ( 1 ) Personal communication to FlyBase  ( 7 ) Abstract  ( 12 ) FlyBase analysis  ( 2 ) Letter  ( 1 ) Curated genome annotation  ( 2 ) Protein sequence record  ( 1 ) Computer file  ( 2 ) Automatic genome annotation  ( 1 ) Book  ( 1 )
Recent research papers ( 28 )
	Abreu-Blanco et al., 2011, J. Cell Biol. 193(3): 455--464 Cell wound repair in Drosophila occurs through three distinct phases of membrane and cytoskeletal remodeling. [FBrf0213583] Abuin et al., 2011, Neuron 69(1): 44--60 Functional architecture of olfactory ionotropic glutamate receptors. [FBrf0212725] Ardehali et al., 2011, EMBO J. 30(14): 2817--2828 Drosophila Set1 is the major histone H3 lysine 4 trimethyltransferase with role in transcription. [FBrf0214333] Cheng et al., 2011, Development 138(5): 831--837 Asymmetric division of cyst stem cells in Drosophila testis is ensured by anaphase spindle repositioning. [FBrf0213009] Cherbas et al., 2011, Genome Res. 21(2): 301--314 The transcriptional diversity of 25 Drosophila cell lines. [FBrf0213077] Goda et al., 2011, PLoS Genet. 7(7): e1002167 Adult Circadian Behavior in Drosophila Requires Developmental Expression of cycle, But Not period. [FBrf0214302] Hughes et al., 2011, PLoS Genet. 7(8): e1002209 Gamma-Tubulin Is Required for Bipolar Spindle Assembly and for Proper Kinetochore Microtubule Attachments during Prometaphase I in Drosophila Oocytes. [FBrf0214729] Jana et al., 2011, Mol. Biol. Cell 22(6): 769--781 Heterotrimeric kinesin-II is necessary and sufficient to promote different stepwise assembly of morphologically distinct bipartite cilia in Drosophila antenna. [FBrf0213262] Koppen et al., 2011, Proteomics 11(22): 4397--4410 Proteomics analyses of microvesicles released by Drosophila Kc167 and S2 cells. [FBrf0216610] Lerit and Gavis, 2011, Curr. Biol. 21(6): 439--448 Transport of germ plasm on astral microtubules directs germ cell development in Drosophila. [FBrf0213255] Ling and Salvaterra, 2011, PLoS ONE 6(3): e17762 Robust RT-qPCR Data Normalization: Validation and Selection of Internal Reference Genes during Post-Experimental Data Analysis. [FBrf0213272] Meyer et al., 2011, Curr. Biol. 21(6): 485--491 Interkinetic nuclear migration is a broadly conserved feature of cell division in pseudostratified epithelia. [FBrf0213254] Ponton et al., 2011, J. Insect Physiol. 57(6): 840--850 Evaluation of potential reference genes for reverse transcription-qPCR studies of physiological responses in Drosophila melanogaster. [FBrf0213828] Puah et al., 2011, BioTechniques 51(1): 49--54 TLM-Converter: reorganization of long time-lapse microscopy datasets for downstream image analysis. [FBrf0214451] Sayal et al., 2011, Fly 5(1): 47--52 Optimization of reporter gene architecture for quantitative measurements of gene expression in the Drosophila embryo. [FBrf0213005] Sun et al., 2011, PLoS ONE 6(4): e18215 Systems-scale analysis reveals pathways involved in cellular response to methamphetamine. [FBrf0213560] Weake et al., 2011, Genes Dev. 25(14): 1499--1509 Post-transcription initiation function of the ubiquitous SAGA complex in tissue-specific gene activation. [FBrf0214372] White et al., 2011, J. Cell Biol. 193(4): 677--694 Drosophila histone locus bodies form by hierarchical recruitment of components. [FBrf0213662] Bechstedt et al., 2010, Nat. Commun. 1: 11 A doublecortin containing microtubule-associated protein is implicated in mechanotransduction in Drosophila sensory cilia. [FBrf0212106] Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Fichelson et al., 2010, Development 137(5): 815--824 lethal giant larvae is required with the par genes for the early polarization of the Drosophila oocyte. [FBrf0209930] Holtzman et al., 2010, Fly 4(4): 349--362 Transgenic tools for members of the genus Drosophila with sequenced genomes. [FBrf0212311] Januschke and Gonzalez, 2010, J. Cell Biol. 188(5): 693--706 The interphase microtubule aster is a determinant of asymmetric division orientation in Drosophila neuroblasts. [FBrf0210175] Kracklauer et al., 2010, J. Cell Sci. 123(Pt 16): 2763--2772 The Drosophila SUN protein Spag4 cooperates with the coiled-coil protein Yuri Gagarin to maintain association of the basal body and spermatid nucleus. [FBrf0211482] Robinson et al., 2010, Mech. Ageing Dev. 131(9): 584--590 Insights into aging through measurements of the Drosophila proteome as a function of temperature. [FBrf0211959] Schulte et al., 2010, J. Neurosci. 30(15): 5189--5203 DMob4/Phocein regulates synapse formation, axonal transport, and microtubule organization. [FBrf0210612] Wang et al., 2010, Cytoskeleton (Hoboken) 67(11): 715--728 Coupling between microtubule sliding, plus-end growth and spindle length revealed by kinesin-8 depletion. [FBrf0212142] Wasbrough et al., 2010, J. Proteomics 73(11): 2171--2185 The Drosophila melanogaster sperm proteome-II (DmSP-II). [FBrf0211978] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...