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Gene Dmel\αTub84B

General Information
Symbol	Dmel\αTub84B	Species	D. melanogaster
Name	α-Tubulin at 84B	Annotation symbol	CG1913
Feature type	protein_coding_gene	FlyBase ID	FBgn0003884
Gene Model Status	Current	Stock availability	19 publicly available
Also Known As	alphaTub84B, α-Tub, αTUB, Tub, α84B, α-tubulin, Tubα1, DM1α, α1, Tuba84B
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	84B2-84B2	Sequence location	3R:2,912,321..2,914,561 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene α-Tubulin at 84B is referred to in FlyBase by the symbol Dmel\αTub84B (CG1913, FBgn0003884). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: structural constituent of cytoskeleton. There is experimental evidence that it is involved in the biological process: mitotic spindle assembly checkpoint; cellular process; mitotic spindle organization; antimicrobial humoral response. 40 alleles are reported. The phenotypes of these alleles are annotated with: spermatid; mesothoracic tergum. It has one annotated transcript and one annotated polypeptide. Protein features are: Alpha tubulin; Tubulin; Tubulin, C-terminal; Tubulin, conserved site; Tubulin/FtsZ, 2-layer sandwich domain; Tubulin/FtsZ, C-terminal; Tubulin/FtsZ, GTPase domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely high expression to a trough of very high expression. Peak expression observed within 00-18 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period. Summary of FlyAtlas Anatomical Expression Data: High levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1623580_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of alphaTub84B. Gene sequence location is 3R:2912321..2914561.
User Contributed Data
	Beta version, feedback welcome
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	αTub84B (α1t) A structural gene for α-Tubulin; present in one copy per haploid genome; transcribed into mRNA in the oocyte and the embryo, reaching a maximum concentration 6-9 hr after the egg is laid (Kalfayan and Wensink, 1982). A variety of post-translational modifications of αTub84b protein found in all tissues, some of which are tissue-specific (Matthews et al., 1989). The gene appears to be constitutively expressed, its functions being common to most cells; the resulting tubulins are very similar to those of other animal species (Theurkauf et al., 1986). Mutations in αTub84B have been induced as lethals over Df(3R)Scx2. Alleles αTub84B1 and αTub84B3 produce proteins that are electrophoretic variants of the wild-type tubulin. Based on the extent of lethality and sterility found in interallelic heterozygotes and in heterozygotes over wild type, the severity of αTub84B alleles can be ordered as follows: αTub84B6 < αTub84B1 < αTub84B2 < αTub84B4 < αTub84B5 = αTub84B3 (Matthews and Kaufman, 1987). Maternal-effect as well as zygotic lethality is shown by the more severe alleles. In the less severe hypomorphic alleles, heterozygotes die late in pupal life or early in adult life, the adults showing head, thoracic, or abdominal defects, bristle abnormalities, leg tremors, and sterility (Matthews and Kaufman, 1987).
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 84B2-84B2   Limits computationally determined from genome sequence between P{lacW}l(3)L2100L2100 and P{EP}EP3060EP3060
Experimentally Determined Cytological Location
Cytogenetic map Notes References 84B-84B   (determined by in situ hybridisation)   (Drosopoulou and Scouras, 1998) 84B4-84C2   (determined by in situ hybridisation)   (Baker and Wolfner, 1988) 84B3-84B6   (determined by in situ hybridisation)   (Natzle and McCarthy, 1984) 84B3-84B6   (determined by in situ hybridisation)   (Mischke and Pardue, 1982) 84B3-84B6   (determined by in situ hybridisation)   (Kalfayan and Wensink, 1981) 84B3-84B6   (determined by in situ hybridisation)   (Sanchez et al., 1980)
Experimentally Determined Recombination Data
Location	3-47.7 (Green et al., 1990, Hays et al., 1989) 3-47.7 +/- 0.1 (Fuller, 1986)
Left of (cM)	p (Hays et al., 1989, Fuller, 1986)
Right of (cM)	Ki (Hays et al., 1989, Fuller, 1986)
Notes	Mapping based on seven recombinants. (Hays et al., 1989)
Gene Model & Products
Please see the GBrowse view of Dmel\αTub84B for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Low-frequency RNA-Seq exon junction(s) not annotated. Gene model reviewed during 5.46
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) αTub84B-RA FBtr0081639  NM_057424   1752   450
Additional Transcript Data & Comments
Reported size (kB)	2.250 (sequence analysis) (Theurkauf et al., 1986) 2.0 (northern blot) (Natzle and McCarthy, 1984) 1.75 (unknown) (Matthews et al., 1989) 1.8 (northern blot) (Kalfayan and Wensink, 1982) 1.3 (unknown) (Baum et al., 1983)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein αTub84B-PA   FBpp0081153   49.9   450   4.78     NP_476772   AAF54067
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Tubulin (IPR000217) Alpha tubulin (IPR002452) Tubulin/FtsZ, GTPase domain (IPR003008) Tubulin/FtsZ, C-terminal (IPR008280) Tubulin, conserved site (IPR017975) Tubulin/FtsZ, 2-layer sandwich domain (IPR018316) Tubulin, C-terminal (IPR023123)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201119   AA201178   AA201204   AA201225   AA201243   AA201285   AA201326   AA201387   AA201516   AA201609   AA201724   AA201731   AA201863   AA201906   AA202060   AA202277   AA202285   AA202347   AA202354   AA202397   AA202535   AA202731   AA202817   AA202919   AA202921   AA203042   AA203048   AA246215   AA246236   AA246280   AA246285   AA246303   AA246399   AA246478   AA246633   AA246684   AA246806   AA246826   AA246950   AA246963   AA247065   AA263211   AA263418   AA263420   AA263503   AA263577   AA263611   AA263619   AA263623   AA263629   AA263714   AA263783   AA263827   AA263924   AA263965   AA264072   AA264082   AA264161   AA264262   AA264366   AA264384   AA264456   AA264505   AA264636   AA264759   AA264777   AA264818   AA264899   AA390286   AA390366   AA390434   AA390440   AA390740   AA390757   AA390859   AA390874   AA390886   AA390959   AA391366   AA391500   AA391629   AA391655   AA391732   AA391838   AA391842   AA391846   AA392182   AA392238   AA392420   AA392672   AA392779   AA392905   AA392935   AA438308   AA438430   AA438444   AA438477   AA438547   AA438621   AA438673   AA438692   AA438750   AA438753   AA438827   AA438990   AA439012   AA439027   AA439117   AA439138   AA439200   AA439329   AA439490   AA439517   AA439594   AA439886   AA439950   AA440214   AA440269   AA440326   AA440338   AA440532   AA440843   AA441101   AA536291   AA536320   AA536336   AA536365   AA536432   AA538600   AA539262   AA539286   AA539289   AA539579   AA539719   AA539731   AA539776   AA539862   AA539997   AA540063   AA540272   AA540321   AA540325   AA540409   AA540466   AA540506   AA540581   AA540629   AA540739   AA540827   AA540847   AA540884   AA540992   AA541006   AA541013   AA567292   AA567385   AA567700   AA567798   AA694778   AA694814   AA694848   AA694920   AA694986   AA695043   AA695171   AA695914   AA696010   AA696086   AA696648   AA696758   AA696820   AA696976   AA697014   AA697147   AA697392   AA698178   AA698186   AA698224   AA698268   AA698682   AA698684   AA698987   AA699226   AA735121   AA735131   AA735134   AA735212   AA735213   AA735429   AA735434   AA735453   AA735527   AA735536   AA735543   AA735629   AA735634   AA735680   AA735808   AA735873   AA801491   AA801564   AA801649   AA801650   AA802336   AA802341   AA802348   AA802410   AA802433   AA802728   AA802921   AA803127   AA803245   AA803307   AA803365   AA803651   AA803970   AA803976   AA803979   AA804022   AA804068   AA816376   AA816424   AA816447   AA816525   AA816566   AA816568   AA816626   AA816627   AA816634   AA816635   AA816814   AA816912   AA817004   AA817027   AA817124   AA817131   AA817148   AA817181   AA817207   AA817220   AA817234   AA817291   AA817455   AA817627   AA817631   AA817653   AA820081   AA820118   AA820210   AA820259   AA820268   AA820293   AA820303   AA820337   AA820388   AA820390   AA820414   AA820467   AA820477   AA820536   AA820565   AA820586   AA820616   AA820663   AA820707   AA820766   AA820770   AA820816   AA820825   AA820849   AA821056   AA821127   AA940661   AA940785   AA940839   AA940902   AA940936   AA940945   AA940965   AA940971   AA940975   AA940988   AA941046   AA941060   AA941175   AA941306   AA941347   AA941427   AA941441   AA941451   AA941496   AA941510   AA941539   AA941569   AA941615   AA941620   AA941689   AA941711   AA941713   AA941764   AA941904   AA941935   AA942000   AA942015   AA942236   AA942366   AA942388   AA942416   AA942475   AA942608   AA942632   AA948786   AA948787   AA949209   AA949321   AA949390   AA949442   AA949593   AA949605   AA949671   AA949696   AA949709   AA949836   AA949888   AA949940   AA949988   AA950093   AA950177   AA950227   AA950270   AA950404   AA950425   AA950455   AA950494   AA950781   AA951035   AA951060   AA951134   AA951149   AA951218   AA951281   AA951376   AA951429   AA951536   AA951583   AA951630   AA951641   AA951656   AA951686   AA951687   AA951786   AA952001   AA952064   AA952066   AA952123   AA952236   AA952282   AA978517   AA978518   AA978636   AA978693   AA978714   AA978769   AA978946   AA979027   AA979049   AA979124   AA979133   AA979155   AA979224   AA979280   AA979333   AA979388   AA979573   AA979590   AA979594   AA979614   AA979650   AA990764   AA990796   AE014297 AAF54067   AC004266   AC008225   AI061787   AI061805   AI061827   AI061856   AI061929   AI061935   AI062299   AI062503   AI062657   AI062861   AI063401   AI063413   AI064361   AI106656   AI106844   AI108122   AI108195   AI108483   AI108807   AI109039   AI109167   AI109543   AI109699   AI109782   AI109927   AI109938   AI110136   AI113455   AI113546   AI113580   AI113754   AI114028   AI124284   AI124313   AI134016   AI134102   AI134134   AI134582   AI134804   AI238675   AI238718   AI238919   AI239151   AI256964   AI257293   AI257352   AI257511   AI257552   AI257576   AI257759   AI257776   AI258076   AI258561   AI258796   AI259240   AI259252   AI259312   AI259415   AI259449   AI259540   AI259588   AI259873   AI259938   AI260029   AI260050   AI260121   AI260893   AI261140   AI292500   AI292563   AI292743   AI293110   AI293579   AI293852   AI293894   AI294029   AI294083   AI294144   AI294401   AI294500   AI294502   AI294584   AI294828   AI294837   AI294899   AI294901   AI295086   AI295096   AI295164   AI295451   AI295497   AI295498   AI295877   AI295905   AI295958   AI296098   AI296159   AI296344   AI296410   AI296745   AI297089   AI297120   AI297614   AI297826   AI386980   AI387157   AI387611   AI387648   AI387786   AI387852   AI387935   AI387999   AI388293   AI388876   AI388936   AI389366   AI389789   AI402653   AI402752   AI402944   AI403791   AI404307   AI404320   AI404735   AI404896   AI405038   AI455045   AI455081   AI455215   AI455584   AI455588   AI455603   AI455652   AI455759   AI455764   AI455788   AI455821   AI455837   AI455858   AI455986   AI456034   AI456109   AI456164   AI456447   AI456448   AI456498   AI456545   AI456575   AI456615   AI456620   AI456663   AI456742   AI456771   AI456774   AI456788   AI456797   AI456862   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AI519191   AI519243   AI519298   AI519364   AI519375   AI519389   AI519465   AI519524   AI519578   AI519618   AI519659   AI519728   AI519772   AI519831   AI519934   AI519955   AI519994   AI520031   AI520109   AI520156   AI520157   AI520414   AI520576   AI520583   AI520592   AI520619   AI531791   AI532237   AI532811   AI532972   AI533067   AI533341   AI534238   AI534350   AI534530   AI541678   AI542138   AI542910   AI543122   AI543222   AI543576   AI543864   AI543881   AI543943   AI544139   AI546294   AI546338   AI546448   AI546471   AI546489   AI945630   AK281777   AK282586   AY113631   AY231787   AY432371   BE975007   BE975236   BE975796   BE975797   BE976281   BE976419   BE977301   BE977621   BE977719   BE978165   BE978166   BE978202   BE978730   BE978790   BF485693   BF485980   BF486327   BF486748   BF487150   BF487807   BF487938   BF487966   BF488009   BF488102   BF488275   BF488433   BF488614   BF488853   BF489120   BF489137   BF489145   BF489603   BF489730   BF489793   BF490040   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BI173653   BI212933   BI212981   BI213355   BI214981   BI215667   BI216035   BI216086   BI216916   BI216978   BI216983   BI227891   BI227911   BI228027   BI228089   BI228242   BI228546   BI228946   BI229151   BI229301   BI229429   BI229452   BI229655   BI230104   BI231063   BI231319   BI231456   BI231528   BI231598   BI231637   BI231652   BI231736   BI231785   BI231926   BI232351   BI232491   BI233057   BI233294   BI234415   BI234928   BI235157   BI235191   BI236059   BI236213   BI236369   BI236738   BI237080   BI237731   BI237772   BI238749   BI239499   BI239742   BI239783   BI240016   BI240037   BI240104   BI240110   BI240411   BI240492   BI240738   BI240803   BI241513   BI242032   BI242222   BI242831   BI243620   BI243735   BI351633   BI351638   BI351726   BI351806   BI351825   BI351836   BI351976   BI352078   BI352101   BI352354   BI352368   BI352389   BI352836   BI352859   BI352915   BI352929   BI353079   BI353193   BI353225   BI353308   BI353364   BI353427   BI353502   BI353852   BI354118   BI354166   BI354903   BI354950   BI354989   BI355093   BI355161   BI355369   BI355431   BI355605   BI356524   BI356554   BI356703   BI357217   BI358447   BI361576   BI362436   BI362659   BI362787   BI362826   BI362882   BI363105   BI363435   BI364389   BI364496   BI364719   BI364742   BI364897   BI365976   BI366465   BI366812   BI367057   BI367888   BI368788   BI369381   BI369442   BI369699   BI370064   BI371116   BI372355   BI372749   BI373304   BI373549   BI373705   BI373985   BI373989   BI374037   BI374225   BI374544   BI374712   BI374926   BI375226   BI375720   BI375816   BI375880   BI375903   BI481781   BI482395   BI483713   BI484263   BI484938   BI484971   BI486577   BI486655   BI487152   BI487188   BI487222   BI564241   BI564790   BI564806   BI565383   BI565679   BI566275   BI566504   BI566690   BI566930   BI567681   BI568095   BI570563   BI570709   BI570758   BI570765   BI571056   BI571332   BI571345   BI571776   BI571871   BI572104   BI572290   BI572409   BI572604   BI572718   BI573047   BI573110   BI574114   BI576045   BI576138   BI576846   BI579397   BI579971   BI580241   BI580993   BI580994   BI581718   BI582221   BI583025   BI583074   BI583903   BI584486   BI584543   BI586705   BI586980   BI586996   BI587950   BI588170   BI588414   BI588639   BI588727   BI590549   BI590684   BI591124   BI591161   BI591165   BI591195   BI592292   BI592358   BI592620   BI592757   BI592784   BI605436   BI605484   BI606576   BI606977   BI607843   BI611173   BI611255   BI612364   BI612632   BI613443   BI613618   BI613953   BI614023   BI615059   BI616611   BI616686   BI616770   BI617050   BI617078   BI617792   BI618990   BI619019   BI619175   BI619959   BI620008   BI620423   BI620528   BI620542   BI621023   BI621197   BI621934   BI621990   BI622262   BI623327   BI624695   BI628585   BI629286   BI629391   BI629525   BI630349   BI631753   BI631942   BI632561   BI632578   BI632684   BI633113   BI633148   BI633830   BI634225   BI634402   BI634500   BI635159   BI635256   BI635781   BI636038   BI636549   BI636832   BI638491   BI638916   BI638959   BI639043   BI639139   BI639630   BI639671   BI639976   BI640056   BI640569   BI640930   BI640992   BI641288   BP550893   BP554879   BP554880   BQ103265   BT012506   BT016118   BT044334   BX005570   BX006068   BX006881   BX007757   BX007996   BX011538   BX012892   BX014125   BX015701   BX016319   BX016721   BX017052   BX019574   BX020136   BX020626   BX020651   BX020705   BX021143   BX022214   BX023695   BX024443   BX025754   BX026827   BX028325   BX029685   BX029799   BX031517   BX032230   BX033080   BX034162   BX034268   BX034454   BX037080   BX038833   BX044536   BX047506   BX051458   BX053542   BX056628   BX057344   BX060127   BX061026   BX061199   BX062157   BX063462   BX064928   BX065134   BX069757   BX070179   BX071989   BX072076   CA807308   CA807456   CK131824   CK131880   CK131896   CK132008   CK132116   CK132293   CK132351   CK132985   CK445185   CK604437   CK604438   CK604571   CK604572   CK604736   CK604737   CK605181   CK605182   CK605271   CK605272   CK605473   CK657178   CK657377   CK657383   CK657691   CK657739   CK657760   CK658078   CK658262   CK658340   CK658479   CK658661   CK658732   CK658872   CK658888   CK659059   CK659188   CK659274   CK659281   CK659391   CK659604   CK659719   CK659831   CK659862   CK660084   CK660120   CK660137   CK660199   CK660223   CK660244   CK660303   CK660364   CK660491   CK660642   CK660756   CK660763   CK660843   CK660855   CK661018   CK661036   CK661086   CK661106   CK661346   CK661381   CK661463   CK661644   CK661658   CK661739   CK661740   CK661758   CK661958   CK662009   CK662198   CK662284   CO152686   CO153232   CO153758   CO153852   CO153890   CO153941   CO153951   CO154026   CO154110   CO155125   CO155155   CO155668   CO156161   CO156476   CO156793   CO156898   CO156935   CO183298   CO185636   CO194774   CO195021   CO263857   CO268092   CO278885   CO293736   CO294985   CO301356   CO302369   CO306043   CO307121   CO307790   CO311646   CO317702   CO332798   CO335369   CO335559   CO335702   CO336144   CO336194   CO336322   CO336345   CO336421   CO336573   CO336674   CO336766   CO337538   CO337621   CO337632   CO337829   CO338239   CO338719   CR938635   DN154505   DQ440241   DQ675550   EC051363   EC057081   EC057900   EC063852   EC076278   EC076591   EC082460   EC085531   EC088521   EC088722   EC201587   EC202289   EC203564   EC214958   EC216650   EC227029   EC228015   EC233963   EC239053   EC243973   EC249061   EC249877   EC261223   EC261418   EC261422   EC261593   EC261688   EC261701   EC261781   EC261845   EC261857   EC262061   EC262460   EC262589   EC262749   EC262777   EC263108   EC263167   EC263283   EC263391   EC263476   EC263696   EC263720   EC263928   EC264724   EC264782   EC264829   EC264897   EC264919   EC265515   EC265650   EC265905   EC265976   EC266834   EC266886   EC267025   EC267344   EC267619   EC267664   EC267799   EL876607   EL876608   EL876708   EL876709   EL876819   EL882243   ES691301   ES691636   ES693989   ES694422   ES694454   ES694483   ES694487   ES694540   ES694572   ES694653   ES694724   ES694731   ES695175   ES695296   EV577982   EV578693   EV578741   EV579148   EV579185   EV579798   EV580971   EV581317   EV582339   EV582857   EV583305   EV583456   EV583875   EV585946   EV586118   EV586182   EV586906   EV588704   EV589604   EV589850   EV590013   EV590381   EV591653   EV592413   EV592747   EV593760   EV594578   M14643 AAA28985
UniProtKB/Swiss-Prot	P06603
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References protein binding site FBsf0000159931 3R:2,912,174..2,912,190 bound_moiety=Trl-XP comment=G3 evidence=experimental (O'Donnell and Wensink, 1994, Bergman et al., 2005) protein binding site FBsf0000159930 3R:2,912,203..2,912,215 comment=G2 evidence=experimental bound_moiety=Trl-XP (O'Donnell and Wensink, 1994, Bergman et al., 2005) protein binding site FBsf0000161129 3R:2,912,212..2,912,230 comment=T2 evidence=experimental bound_moiety=Tbf1-XP (O'Donnell and Wensink, 1994, Bergman et al., 2005) protein binding site FBsf0000159929 3R:2,912,222..2,912,237 comment=G1 evidence=experimental bound_moiety=Trl-XP (O'Donnell and Wensink, 1994, Bergman et al., 2005) protein binding site FBsf0000159928 3R:2,912,239..2,912,250 comment=T1 evidence=experimental bound_moiety=Tbf1-XP (O'Donnell and Wensink, 1994, Bergman et al., 2005) protein binding site FBsf0000159925 3R:2,912,698..2,912,710 bound_moiety=Tbf1-XP comment=T5 evidence=experimental (O'Donnell and Wensink, 1994, Bergman et al., 2005) protein binding site FBsf0000159927 3R:2,912,729..2,912,751 evidence=experimental bound_moiety=Tbf1-XP comment=T3 (Bergman et al., 2005, O'Donnell and Wensink, 1994) protein binding site FBsf0000159926 3R:2,912,829..2,912,833 comment=T4 evidence=experimental bound_moiety=Tbf1-XP (O'Donnell and Wensink, 1994, Bergman et al., 2005) protein binding site FBsf0000160508 3R:2,912,768..2,912,795 bound_moiety=Trl-XP evidence=experimental (O'Donnell and Wensink, 1994, Bergman et al., 2005) protein binding site FBsf0000160509 3R:2,912,848..2,912,861 bound_moiety=Trl-XP evidence=experimental (O'Donnell and Wensink, 1994, Bergman et al., 2005) protein binding site FBsf0000161114 3R:2,912,221..2,912,250 evidence=experimental (Bergman et al., 2005, O'Donnell and Wensink, 1994) protein binding site FBsf0000161115 3R:2,912,811..2,912,822 bound_moiety=Trl-XP evidence=experimental (O'Donnell and Wensink, 1994, Bergman et al., 2005) regulatory region FBsf0000161322 3R:2,912,166..2,912,233 comment=One of three regions that activate transcription in in vitro assays comment=Tubulin Element 2 (TE2) evidence=experimental (O'Donnell et al., 1994) regulatory region FBsf0000161323 3R:2,912,234..2,912,262 comment=One of three regions that activate transcription in in vitro assays comment=Tubulin Element 1 (TE1) evidence=experimental (O'Donnell et al., 1994) regulatory region FBsf0000161324 3R:2,912,467..2,912,955 comment=One of three regions that activate transcription in in vitro assays evidence=experimental (O'Donnell et al., 1994) regulatory region FBsf0000435470 3R:2,912,166..2,912,233 evidence=Reporter construct (in vitro) (O'Donnell et al., 1994, Halfon, 2012.6.19) regulatory region FBsf0000436129 3R:2,912,166..2,913,020 evidence=Reporter construct (in vivo) (O'Donnell et al., 1994, Halfon, 2012.6.19) regulatory region FBsf0000436236 3R:2,912,234..2,912,262 evidence=Reporter construct (in vitro) (O'Donnell et al., 1994, Halfon, 2012.6.19)
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Matthews et al., 1989) embryonic stage 1 -- 15     (Kalfayan and Wensink, 1982) Comment:reference states 0-12 hr AEL embryonic stage 1 -- 17     (Natzle and McCarthy, 1984) Comment:reference states 0-21 hr AEL larval stage     (Kalfayan and Wensink, 1982) first instar larval stage     (Natzle and McCarthy, 1984) second instar larval stage     (Natzle and McCarthy, 1984) third instar larval stage     (Natzle and McCarthy, 1984) prepupal stage     (Natzle and McCarthy, 1984) pupal stage     (Kalfayan and Wensink, 1982, Natzle and McCarthy, 1984) adult stage     (Kalfayan and Wensink, 1982)
Additional Descriptive Data
	αTub84B transcript is detected in all developmental stages. (Matthews et al., 1989) Expression ofαTub84B is abundant throughout development, with the highest concentrationof transcript expressed at 6-9 hours of embryonic development. (Kalfayan and Wensink, 1982) The αTub84Btranscript is expressed at all stages of development, with highest levelsdetected betweeen 0 and 6 hours of embryonic development, and high levelsbetween 9 and 18 hours of embryonic development and the first and second larvalinstars. (Natzle and McCarthy, 1984)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference wandering third instar larval stage   neuromuscular junction   • microtubule of axon (Trotta et al., 2004) Comment:not in synaptic boutons muscle cell   (Trotta et al., 2004) mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Dorus et al., 2006, Wasbrough et al., 2010) day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011) western blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 4     (Matthews et al., 1989) Comment:reference states 0-2 hr AEL embryonic stage 12 -- 15     (Matthews et al., 1989) Comment:reference states 9-13 hr AEL embryonic stage 17     (Matthews et al., 1989) Comment:reference states 16-20 hr AEL third instar larval stage   imaginal disc   (Matthews et al., 1989) central nervous system   (Matthews et al., 1989) pupal stage | mid     (Matthews et al., 1989) adult stage   gonad   (Matthews et al., 1989)   (Matthews et al., 1989) adult head   (Matthews et al., 1989)
Additional Descriptive Data
	To compare synthesis and accumulation of α-tubulin proteins, 35S</up>methionine radiolabeled tissues were subjected to Western analysis using monoclonal anti-α-tubulin antibody. The predominant α-tubulin protein in all tissues and stages examined is αTub84B protein. The protein did not accumulate in the adult head. (Matthews et al., 1989) localization of acetylated or glutamylated tubulin detected; found only in stabilized microtubules. (Trotta et al., 2004)
Marker for
	microtubule &&of neuromuscular junction
Subcellular Localization (GO Cellular Component)
CV term Evidence References
astral microtubule inferred from direct assay (Hallen et al., 2008) centrosome inferred from direct assay (Hallen et al., 2008) spindle inferred from direct assay (Maiato et al., 2004, Hallen et al., 2008)
Expression Deduced from Reporters
Reporter: P{αTub84B(FRT.Gal80.y+)GAL4.C} Stage Tissue/Position (including subcellular localization) Reference first instar larval stage -- second instar larval stage     (Zecca and Struhl, 2002) Reporter: P{CXY21.29+33}X15P{CXY21.29+33} Stage Tissue/Position (including subcellular localization) Reference   organism | ubiquitous   (Zhang and Kalderon, 2000) Reporter: P{CXY21.29+33}X15P{CXY21.29+33} Stage Tissue/Position (including subcellular localization) Reference   organism | ubiquitous   (Zhang and Kalderon, 2000) Reporter: P{CXY21.29+4a}X15P{CXY21.29+4a} Stage Tissue/Position (including subcellular localization) Reference   organism | ubiquitous   (Zhang and Kalderon, 2000) Reporter: P{CXY21.29+4a}X15P{CXY21.29+4a} Stage Tissue/Position (including subcellular localization) Reference   organism | ubiquitous   (Zhang and Kalderon, 2000) Reporter: P{GAL4-αTub84B(-FRT).VP16F442A} Stage Tissue/Position (including subcellular localization) Reference embryonic stage   organism | ubiquitous   (Struhl and Adachi, 1998, Struhl and Greenwald, 2001) larval stage   organism | ubiquitous   (Jia et al., 2004, Wang et al., 1999)
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    2890.375 Larval Midgut    5886.3 Larval Hindgut    4908.8 Larval Malpighian Tubules    3259.4 Larval Fat Body    3469.2 Larval Salivary Gland    6429.8 Larval Trachea    4580.725 Larval Carcass    4742.625 Adult Head    2444.9 Adult Eye    2302.8 Adult Brain    2669.6 Adult Thoracic-Abdominal Ganglion    3498 Adult Crop    2928.8 Adult Midgut    2406.8 Adult Hindgut    2897.4 Adult Malpighian Tubules    2740.5 Adult Fat Body    2723.8 Adult Salivary Gland    2046.3 Adult Heart    1328.55 Adult VirginFemale Spermatheca    3066 Adult InseminatedFemale Spermatheca    3298 Adult Ovary    2546.8 Adult Testis    2961 Adult Male Accessory Gland    2686.4 Adult Carcass    2179.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (2890.375) Larval Midgut  (5886.3) Larval Hindgut  (4908.8) Larval Malpighian Tubules  (3259.4) Larval Fat Body  (3469.2) Larval Salivary Gland  (6429.8) Larval Trachea  (4580.725) Larval Carcass  (4742.625) Adult Head  (2444.9) Adult Eye  (2302.8) Adult Brain  (2669.6) Adult Thoracic-Abdominal Ganglion  (3498) Adult Crop  (2928.8) Adult Midgut  (2406.8) Adult Hindgut  (2897.4) Adult Malpighian Tubules  (2740.5) Adult Fat Body  (2723.8) Adult Salivary Gland  (2046.3) Adult Heart  (1328.55) Adult VirginFemale Spermatheca  (3066) Adult InseminatedFemale Spermatheca  (3298) Adult Ovary  (2546.8) Adult Testis  (2961) Adult Male Accessory Gland  (2686.4) Adult Carcass  (2179.1) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (2890.375) Larval Midgut  (5886.3) Larval Hindgut  (4908.8) Larval Malpighian Tubules  (3259.4) Larval Fat Body  (3469.2) Larval Salivary Gland  (6429.8) Larval Trachea  (4580.725) Larval Carcass  (4742.625) Adult Head  (2444.9) Adult Eye  (2302.8) Adult Brain  (2669.6) Adult Thoracic-Abdominal Ganglion  (3498) Adult Crop  (2928.8) Adult Midgut  (2406.8) Adult Hindgut  (2897.4) Adult Malpighian Tubules  (2740.5) Adult Fat Body  (2723.8) Adult Salivary Gland  (2046.3) Adult Heart  (1328.55) Adult VirginFemale Spermatheca  (3066) Adult InseminatedFemale Spermatheca  (3298) Adult Ovary  (2546.8) Adult Testis  (2961) Adult Male Accessory Gland  (2686.4) Adult Carcass  (2179.1) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    2890.375 Larval Midgut    5886.3 Larval Hindgut    4908.8 Larval Malpighian Tubules    3259.4 Larval Fat Body    3469.2 Larval Salivary Gland    6429.8 Larval Trachea    4580.725 Larval Carcass    4742.625 Adult Head    2444.9 Adult Eye    2302.8 Adult Brain    2669.6 Adult Thoracic-Abdominal Ganglion    3498 Adult Crop    2928.8 Adult Midgut    2406.8 Adult Hindgut    2897.4 Adult Malpighian Tubules    2740.5 Adult Fat Body    2723.8 Adult Salivary Gland    2046.3 Adult Heart    1328.55 Adult VirginFemale Spermatheca    3066 Adult InseminatedFemale Spermatheca    3298 Adult Ovary    2546.8 Adult Testis    2961 Adult Male Accessory Gland    2686.4 Adult Carcass    2179.1 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    2890.375 Larval Midgut    5886.3 Larval Hindgut    4908.8 Larval Malpighian Tubules    3259.4 Larval Fat Body    3469.2 Larval Salivary Gland    6429.8 Larval Trachea    4580.725 Larval Carcass    4742.625 Adult Head    2444.9 Adult Eye    2302.8 Adult Brain    2669.6 Adult Thoracic-Abdominal Ganglion    3498 Adult Crop    2928.8 Adult Midgut    2406.8 Adult Hindgut    2897.4 Adult Malpighian Tubules    2740.5 Adult Fat Body    2723.8 Adult Salivary Gland    2046.3 Adult Heart    1328.55 Adult VirginFemale Spermatheca    3066 Adult InseminatedFemale Spermatheca    3298 Adult Ovary    2546.8 Adult Testis    2961 Adult Male Accessory Gland    2686.4 Adult Carcass    2179.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (2890.375) Larval Midgut  (5886.3) Larval Hindgut  (4908.8) Larval Malpighian Tubules  (3259.4) Larval Fat Body  (3469.2) Larval Salivary Gland  (6429.8) Larval Trachea  (4580.725) Larval Carcass  (4742.625) Adult Head  (2444.9) Adult Eye  (2302.8) Adult Brain  (2669.6) Adult Thoracic-Abdominal Ganglion  (3498) Adult Crop  (2928.8) Adult Midgut  (2406.8) Adult Hindgut  (2897.4) Adult Malpighian Tubules  (2740.5) Adult Fat Body  (2723.8) Adult Salivary Gland  (2046.3) Adult Heart  (1328.55) Adult VirginFemale Spermatheca  (3066) Adult InseminatedFemale Spermatheca  (3298) Adult Ovary  (2546.8) Adult Testis  (2961) Adult Male Accessory Gland  (2686.4) Adult Carcass  (2179.1) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (2890.375) Larval Midgut  (5886.3) Larval Hindgut  (4908.8) Larval Malpighian Tubules  (3259.4) Larval Fat Body  (3469.2) Larval Salivary Gland  (6429.8) Larval Trachea  (4580.725) Larval Carcass  (4742.625) Adult Head  (2444.9) Adult Eye  (2302.8) Adult Brain  (2669.6) Adult Thoracic-Abdominal Ganglion  (3498) Adult Crop  (2928.8) Adult Midgut  (2406.8) Adult Hindgut  (2897.4) Adult Malpighian Tubules  (2740.5) Adult Fat Body  (2723.8) Adult Salivary Gland  (2046.3) Adult Heart  1328.55 Adult VirginFemale Spermatheca  (3066) Adult InseminatedFemale Spermatheca  (3298) Adult Ovary  (2546.8) Adult Testis  (2961) Adult Male Accessory Gland  (2686.4) Adult Carcass  (2179.1) Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    2890.375 Larval Midgut    5886.3 Larval Hindgut    4908.8 Larval Malpighian Tubules    3259.4 Larval Fat Body    3469.2 Larval Salivary Gland    6429.8 Larval Trachea    4580.725 Larval Carcass    4742.625 Adult Head    2444.9 Adult Eye    2302.8 Adult Brain    2669.6 Adult Thoracic-Abdominal Ganglion    3498 Adult Crop    2928.8 Adult Midgut    2406.8 Adult Hindgut    2897.4 Adult Malpighian Tubules    2740.5 Adult Fat Body    2723.8 Adult Salivary Gland    2046.3 Adult Heart    1328.55 Adult VirginFemale Spermatheca    3066 Adult InseminatedFemale Spermatheca    3298 Adult Ovary    2546.8 Adult Testis    2961 Adult Male Accessory Gland    2686.4 Adult Carcass    2179.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    2444.9   NA  Eye    2302.8   NA  Brain    2669.6   2890.375  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    3498   NA  Crop    2928.8   5886.3  Midgut    2406.8   4908.8  Hindgut    2897.4   3259.4  Malpighian Tubules    2740.5   3469.2  Fat Body    2723.8   6429.8  Salivary Gland    2046.3   NA  Heart    1328.55   4580.725  Trachea    NA   NA  VirginFemale Spermatheca    3066   NA  InseminatedFemale Spermatheca    3298   NA  Ovary    2546.8   NA  Testis    2961   NA  Male Accessory Gland    2686.4   4742.625  Carcass    2179.1 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    2755 central nervous system, larvae L3    2467 central nervous system, pupae P8    2186 head, virgin 1-day female    605 head, virgin 4-day female    386 head, virgin 20-day female    406 head, mated 1-day female    355 head, mated 4-day female    294 head, mated 20-day female    345 head, mated 1-day male    656 head, mated 4-day male    533 head, mated 20-day male    551 salivary gland, larvae L3 wandering    145 salivary gland, white prepupae    489 digestive system, larvae L3 wandering    849 digestive system, 1-day adult    447 digestive system, 4-day adult    372 digestive system, 20-day adult    535 fat body, larvae L3 wandering    562 fat body, white prepupae    653 fat body, pupae P8    1465 carcass, larvae L3 wandering    1800 carcass, 1-day adult    420 carcass, 4-day adult    417 carcass, 20-day adult    431 ovary, virgin 4-day female    1177 ovary, mated 4-day female    1028 testis, mated 4-day male    1828 accessory gland, mated 4-day male    509 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (2755) central nervous system, larvae L3  (2467) central nervous system, pupae P8  (2186) head, virgin 1-day female  (605) head, virgin 4-day female  (386) head, virgin 20-day female  (406) head, mated 1-day female  (355) head, mated 4-day female  (294) head, mated 20-day female  (345) head, mated 1-day male  (656) head, mated 4-day male  (533) head, mated 20-day male  (551) salivary gland, larvae L3 wandering  (145) salivary gland, white prepupae  (489) digestive system, larvae L3 wandering  (849) digestive system, 1-day adult  (447) digestive system, 4-day adult  (372) digestive system, 20-day adult  (535) fat body, larvae L3 wandering  (562) fat body, white prepupae  (653) fat body, pupae P8  (1465) carcass, larvae L3 wandering  (1800) carcass, 1-day adult  (420) carcass, 4-day adult  (417) carcass, 20-day adult  (431) ovary, virgin 4-day female  (1177) ovary, mated 4-day female  (1028) testis, mated 4-day male  (1828) accessory gland, mated 4-day male  (509) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (2755) central nervous system, larvae L3  (2467) central nervous system, pupae P8  (2186) head, virgin 1-day female  (605) head, virgin 4-day female  (386) head, virgin 20-day female  (406) head, mated 1-day female  (355) head, mated 4-day female  (294) head, mated 20-day female  (345) head, mated 1-day male  (656) head, mated 4-day male  (533) head, mated 20-day male  (551) salivary gland, larvae L3 wandering  (145) salivary gland, white prepupae  (489) digestive system, larvae L3 wandering  (849) digestive system, 1-day adult  (447) digestive system, 4-day adult  (372) digestive system, 20-day adult  (535) fat body, larvae L3 wandering  (562) fat body, white prepupae  (653) fat body, pupae P8  (1465) carcass, larvae L3 wandering  (1800) carcass, 1-day adult  (420) carcass, 4-day adult  (417) carcass, 20-day adult  (431) ovary, virgin 4-day female  (1177) ovary, mated 4-day female  (1028) testis, mated 4-day male  (1828) accessory gland, mated 4-day male  (509) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2755 central nervous system, larvae L3    2467 central nervous system, pupae P8    2186 head, virgin 1-day female    605 head, virgin 4-day female    386 head, virgin 20-day female    406 head, mated 1-day female    355 head, mated 4-day female    294 head, mated 20-day female    345 head, mated 1-day male    656 head, mated 4-day male    533 head, mated 20-day male    551 salivary gland, larvae L3 wandering    145 salivary gland, white prepupae    489 digestive system, larvae L3 wandering    849 digestive system, 1-day adult    447 digestive system, 4-day adult    372 digestive system, 20-day adult    535 fat body, larvae L3 wandering    562 fat body, white prepupae    653 fat body, pupae P8    1465 carcass, larvae L3 wandering    1800 carcass, 1-day adult    420 carcass, 4-day adult    417 carcass, 20-day adult    431 ovary, virgin 4-day female    1177 ovary, mated 4-day female    1028 testis, mated 4-day male    1828 accessory gland, mated 4-day male    509 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    2755 central nervous system, larvae L3    2467 central nervous system, pupae P8    2186 head, virgin 1-day female    605 head, virgin 4-day female    386 head, virgin 20-day female    406 head, mated 1-day female    355 head, mated 4-day female    294 head, mated 20-day female    345 head, mated 1-day male    656 head, mated 4-day male    533 head, mated 20-day male    551 salivary gland, larvae L3 wandering    145 salivary gland, white prepupae    489 digestive system, larvae L3 wandering    849 digestive system, 1-day adult    447 digestive system, 4-day adult    372 digestive system, 20-day adult    535 fat body, larvae L3 wandering    562 fat body, white prepupae    653 fat body, pupae P8    1465 carcass, larvae L3 wandering    1800 carcass, 1-day adult    420 carcass, 4-day adult    417 carcass, 20-day adult    431 ovary, virgin 4-day female    1177 ovary, mated 4-day female    1028 testis, mated 4-day male    1828 accessory gland, mated 4-day male    509 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (2755) central nervous system, larvae L3  (2467) central nervous system, pupae P8  (2186) head, virgin 1-day female  (605) head, virgin 4-day female  (386) head, virgin 20-day female  (406) head, mated 1-day female  (355) head, mated 4-day female  (294) head, mated 20-day female  (345) head, mated 1-day male  (656) head, mated 4-day male  (533) head, mated 20-day male  (551) salivary gland, larvae L3 wandering  (145) salivary gland, white prepupae  (489) digestive system, larvae L3 wandering  (849) digestive system, 1-day adult  (447) digestive system, 4-day adult  (372) digestive system, 20-day adult  (535) fat body, larvae L3 wandering  (562) fat body, white prepupae  (653) fat body, pupae P8  (1465) carcass, larvae L3 wandering  (1800) carcass, 1-day adult  (420) carcass, 4-day adult  (417) carcass, 20-day adult  (431) ovary, virgin 4-day female  (1177) ovary, mated 4-day female  (1028) testis, mated 4-day male  (1828) accessory gland, mated 4-day male  (509) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (2755) central nervous system, larvae L3  (2467) central nervous system, pupae P8  (2186) head, virgin 1-day female  (605) head, virgin 4-day female  (386) head, virgin 20-day female  (406) head, mated 1-day female  (355) head, mated 4-day female  (294) head, mated 20-day female  (345) head, mated 1-day male  (656) head, mated 4-day male  (533) head, mated 20-day male  (551) salivary gland, larvae L3 wandering  (145) salivary gland, white prepupae  (489) digestive system, larvae L3 wandering  (849) digestive system, 1-day adult  (447) digestive system, 4-day adult  (372) digestive system, 20-day adult  (535) fat body, larvae L3 wandering  (562) fat body, white prepupae  (653) fat body, pupae P8  (1465) carcass, larvae L3 wandering  (1800) carcass, 1-day adult  (420) carcass, 4-day adult  (417) carcass, 20-day adult  (431) ovary, virgin 4-day female  (1177) ovary, mated 4-day female  (1028) testis, mated 4-day male  (1828) accessory gland, mated 4-day male  (509) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2755 central nervous system, larvae L3    2467 central nervous system, pupae P8    2186 head, virgin 1-day female    605 head, virgin 4-day female    386 head, virgin 20-day female    406 head, mated 1-day female    355 head, mated 4-day female    294 head, mated 20-day female    345 head, mated 1-day male    656 head, mated 4-day male    533 head, mated 20-day male    551 salivary gland, larvae L3 wandering    145 salivary gland, white prepupae    489 digestive system, larvae L3 wandering    849 digestive system, 1-day adult    447 digestive system, 4-day adult    372 digestive system, 20-day adult    535 fat body, larvae L3 wandering    562 fat body, white prepupae    653 fat body, pupae P8    1465 carcass, larvae L3 wandering    1800 carcass, 1-day adult    420 carcass, 4-day adult    417 carcass, 20-day adult    431 ovary, virgin 4-day female    1177 ovary, mated 4-day female    1028 testis, mated 4-day male    1828 accessory gland, mated 4-day male    509 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely high expression to a trough of very high expression. Peak expression observed within 00-18 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    1715 embryo 02-04hr    3294 embryo 04-06hr    4229 embryo 06-08hr    4380 embryo 08-10hr    3017 embryo 10-12hr    2854 embryo 12-14hr    2143 embryo 14-16hr    2835 embryo 16-18hr    1561 embryo 18-20hr    1254 embryo 20-22hr    933 embryo 22-24hr    820 larva L1    1581 larva L2    2115 larva L3 12hr old    1668 larva L3 puffstage 1-2    1361 larva L3 puffstage 3-6    1515 larva L3 puffstage 7-9    1723 white prepupae new    2059 white prepupae 12hr    1904 white prepupae 24hr    2790 pupae 2d postWPP    3004 pupae 3d postWPP    1858 pupae 4d postWPP    1799 adult male 01day    1069 adult male 05day    1341 adult male 30day    1315 adult female 01day    1187 adult female 05day    1150 adult female 30day    1137 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (1715) embryo 02-04hr  (3294) embryo 04-06hr  (4229) embryo 06-08hr  (4380) embryo 08-10hr  (3017) embryo 10-12hr  (2854) embryo 12-14hr  (2143) embryo 14-16hr  (2835) embryo 16-18hr  (1561) embryo 18-20hr  (1254) embryo 20-22hr  (933) embryo 22-24hr  (820) larva L1  (1581) larva L2  (2115) larva L3 12hr old  (1668) larva L3 puffstage 1-2  (1361) larva L3 puffstage 3-6  (1515) larva L3 puffstage 7-9  (1723) white prepupae new  (2059) white prepupae 12hr  (1904) white prepupae 24hr  (2790) pupae 2d postWPP  (3004) pupae 3d postWPP  (1858) pupae 4d postWPP  (1799) adult male 01day  (1069) adult male 05day  (1341) adult male 30day  (1315) adult female 01day  (1187) adult female 05day  (1150) adult female 30day  (1137) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (1715) embryo 02-04hr  (3294) embryo 04-06hr  (4229) embryo 06-08hr  (4380) embryo 08-10hr  (3017) embryo 10-12hr  (2854) embryo 12-14hr  (2143) embryo 14-16hr  (2835) embryo 16-18hr  (1561) embryo 18-20hr  (1254) embryo 20-22hr  (933) embryo 22-24hr  (820) larva L1  (1581) larva L2  (2115) larva L3 12hr old  (1668) larva L3 puffstage 1-2  (1361) larva L3 puffstage 3-6  (1515) larva L3 puffstage 7-9  (1723) white prepupae new  (2059) white prepupae 12hr  (1904) white prepupae 24hr  (2790) pupae 2d postWPP  (3004) pupae 3d postWPP  (1858) pupae 4d postWPP  (1799) adult male 01day  (1069) adult male 05day  (1341) adult male 30day  (1315) adult female 01day  (1187) adult female 05day  (1150) adult female 30day  (1137) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1715 embryo 02-04hr    3294 embryo 04-06hr    4229 embryo 06-08hr    4380 embryo 08-10hr    3017 embryo 10-12hr    2854 embryo 12-14hr    2143 embryo 14-16hr    2835 embryo 16-18hr    1561 embryo 18-20hr    1254 embryo 20-22hr    933 embryo 22-24hr    820 larva L1    1581 larva L2    2115 larva L3 12hr old    1668 larva L3 puffstage 1-2    1361 larva L3 puffstage 3-6    1515 larva L3 puffstage 7-9    1723 white prepupae new    2059 white prepupae 12hr    1904 white prepupae 24hr    2790 pupae 2d postWPP    3004 pupae 3d postWPP    1858 pupae 4d postWPP    1799 adult male 01day    1069 adult male 05day    1341 adult male 30day    1315 adult female 01day    1187 adult female 05day    1150 adult female 30day    1137 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    1715 embryo 02-04hr    3294 embryo 04-06hr    4229 embryo 06-08hr    4380 embryo 08-10hr    3017 embryo 10-12hr    2854 embryo 12-14hr    2143 embryo 14-16hr    2835 embryo 16-18hr    1561 embryo 18-20hr    1254 embryo 20-22hr    933 embryo 22-24hr    820 larva L1    1581 larva L2    2115 larva L3 12hr old    1668 larva L3 puffstage 1-2    1361 larva L3 puffstage 3-6    1515 larva L3 puffstage 7-9    1723 white prepupae new    2059 white prepupae 12hr    1904 white prepupae 24hr    2790 pupae 2d postWPP    3004 pupae 3d postWPP    1858 pupae 4d postWPP    1799 adult male 01day    1069 adult male 05day    1341 adult male 30day    1315 adult female 01day    1187 adult female 05day    1150 adult female 30day    1137 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (1715) embryo 02-04hr  (3294) embryo 04-06hr  (4229) embryo 06-08hr  (4380) embryo 08-10hr  (3017) embryo 10-12hr  (2854) embryo 12-14hr  (2143) embryo 14-16hr  (2835) embryo 16-18hr  (1561) embryo 18-20hr  (1254) embryo 20-22hr  (933) embryo 22-24hr  (820) larva L1  (1581) larva L2  (2115) larva L3 12hr old  (1668) larva L3 puffstage 1-2  (1361) larva L3 puffstage 3-6  (1515) larva L3 puffstage 7-9  (1723) white prepupae new  (2059) white prepupae 12hr  (1904) white prepupae 24hr  (2790) pupae 2d postWPP  (3004) pupae 3d postWPP  (1858) pupae 4d postWPP  (1799) adult male 01day  (1069) adult male 05day  (1341) adult male 30day  (1315) adult female 01day  (1187) adult female 05day  (1150) adult female 30day  (1137) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (1715) embryo 02-04hr  (3294) embryo 04-06hr  (4229) embryo 06-08hr  (4380) embryo 08-10hr  (3017) embryo 10-12hr  (2854) embryo 12-14hr  (2143) embryo 14-16hr  (2835) embryo 16-18hr  (1561) embryo 18-20hr  (1254) embryo 20-22hr  (933) embryo 22-24hr  (820) larva L1  (1581) larva L2  (2115) larva L3 12hr old  (1668) larva L3 puffstage 1-2  (1361) larva L3 puffstage 3-6  (1515) larva L3 puffstage 7-9  (1723) white prepupae new  (2059) white prepupae 12hr  (1904) white prepupae 24hr  (2790) pupae 2d postWPP  (3004) pupae 3d postWPP  (1858) pupae 4d postWPP  (1799) adult male 01day  (1069) adult male 05day  (1341) adult male 30day  (1315) adult female 01day  (1187) adult female 05day  (1150) adult female 30day  (1137) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1715 embryo 02-04hr    3294 embryo 04-06hr    4229 embryo 06-08hr    4380 embryo 08-10hr    3017 embryo 10-12hr    2854 embryo 12-14hr    2143 embryo 14-16hr    2835 embryo 16-18hr    1561 embryo 18-20hr    1254 embryo 20-22hr    933 embryo 22-24hr    820 larva L1    1581 larva L2    2115 larva L3 12hr old    1668 larva L3 puffstage 1-2    1361 larva L3 puffstage 3-6    1515 larva L3 puffstage 7-9    1723 white prepupae new    2059 white prepupae 12hr    1904 white prepupae 24hr    2790 pupae 2d postWPP    3004 pupae 3d postWPP    1858 pupae 4d postWPP    1799 adult male 01day    1069 adult male 05day    1341 adult male 30day    1315 adult female 01day    1187 adult female 05day    1150 adult female 30day    1137 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    1893 Schneider line 2 Sg4    2947 embryonic 1182-4H    3558 embryonic GM2    1837 embryonic Kc167    367 embryonic S1    1888 embryonic S3    1973 leg disc CME L1    2933 wing disc CME-W2    2326 wing disc ML-DmD8    2955 wing disc ML-DmD9    3135 wing disc ML-DmD16-c3    1974 wing disc ML-DmD21    3618 wing disc ML-DmD32    3275 haltere disc ML-DmD17-c3    2886 eye-antennal disc ML-DmD11    4216 antennal disc ML-DmD20-c5    4268 mixed discs ML-DmD4-c1    2950 CNS ML-DmBG1-c1    2433 CNS ML-DmBG2-c2    1616 tumorous blood cells mbn2    1454 ovary fGS/OSS    1833 ovary OSC    1542 ovary OSS    792 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (1893) Schneider line 2 Sg4  (2947) embryonic 1182-4H  (3558) embryonic GM2  (1837) embryonic Kc167  (367) embryonic S1  (1888) embryonic S3  (1973) leg disc CME L1  (2933) wing disc CME-W2  (2326) wing disc ML-DmD8  (2955) wing disc ML-DmD9  (3135) wing disc ML-DmD16-c3  (1974) wing disc ML-DmD21  (3618) wing disc ML-DmD32  (3275) haltere disc ML-DmD17-c3  (2886) eye-antennal disc ML-DmD11  (4216) antennal disc ML-DmD20-c5  (4268) mixed discs ML-DmD4-c1  (2950) CNS ML-DmBG1-c1  (2433) CNS ML-DmBG2-c2  (1616) tumorous blood cells mbn2  (1454) ovary fGS/OSS  (1833) ovary OSC  (1542) ovary OSS  (792) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (1893) Schneider line 2 Sg4  (2947) embryonic 1182-4H  (3558) embryonic GM2  (1837) embryonic Kc167  (367) embryonic S1  (1888) embryonic S3  (1973) leg disc CME L1  (2933) wing disc CME-W2  (2326) wing disc ML-DmD8  (2955) wing disc ML-DmD9  (3135) wing disc ML-DmD16-c3  (1974) wing disc ML-DmD21  (3618) wing disc ML-DmD32  (3275) haltere disc ML-DmD17-c3  (2886) eye-antennal disc ML-DmD11  (4216) antennal disc ML-DmD20-c5  (4268) mixed discs ML-DmD4-c1  (2950) CNS ML-DmBG1-c1  (2433) CNS ML-DmBG2-c2  (1616) tumorous blood cells mbn2  (1454) ovary fGS/OSS  (1833) ovary OSC  (1542) ovary OSS  (792) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    1893 Schneider line 2 Sg4    2947 embryonic 1182-4H    3558 embryonic GM2    1837 embryonic Kc167    367 embryonic S1    1888 embryonic S3    1973 leg disc CME L1    2933 wing disc CME-W2    2326 wing disc ML-DmD8    2955 wing disc ML-DmD9    3135 wing disc ML-DmD16-c3    1974 wing disc ML-DmD21    3618 wing disc ML-DmD32    3275 haltere disc ML-DmD17-c3    2886 eye-antennal disc ML-DmD11    4216 antennal disc ML-DmD20-c5    4268 mixed discs ML-DmD4-c1    2950 CNS ML-DmBG1-c1    2433 CNS ML-DmBG2-c2    1616 tumorous blood cells mbn2    1454 ovary fGS/OSS    1833 ovary OSC    1542 ovary OSS    792 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    1893 Schneider line 2 Sg4    2947 embryonic 1182-4H    3558 embryonic GM2    1837 embryonic Kc167    367 embryonic S1    1888 embryonic S3    1973 leg disc CME L1    2933 wing disc CME-W2    2326 wing disc ML-DmD8    2955 wing disc ML-DmD9    3135 wing disc ML-DmD16-c3    1974 wing disc ML-DmD21    3618 wing disc ML-DmD32    3275 haltere disc ML-DmD17-c3    2886 eye-antennal disc ML-DmD11    4216 antennal disc ML-DmD20-c5    4268 mixed discs ML-DmD4-c1    2950 CNS ML-DmBG1-c1    2433 CNS ML-DmBG2-c2    1616 tumorous blood cells mbn2    1454 ovary fGS/OSS    1833 ovary OSC    1542 ovary OSS    792 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (1893) Schneider line 2 Sg4  (2947) embryonic 1182-4H  (3558) embryonic GM2  (1837) embryonic Kc167  (367) embryonic S1  (1888) embryonic S3  (1973) leg disc CME L1  (2933) wing disc CME-W2  (2326) wing disc ML-DmD8  (2955) wing disc ML-DmD9  (3135) wing disc ML-DmD16-c3  (1974) wing disc ML-DmD21  (3618) wing disc ML-DmD32  (3275) haltere disc ML-DmD17-c3  (2886) eye-antennal disc ML-DmD11  (4216) antennal disc ML-DmD20-c5  (4268) mixed discs ML-DmD4-c1  (2950) CNS ML-DmBG1-c1  (2433) CNS ML-DmBG2-c2  (1616) tumorous blood cells mbn2  (1454) ovary fGS/OSS  (1833) ovary OSC  (1542) ovary OSS  (792) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (1893) Schneider line 2 Sg4  (2947) embryonic 1182-4H  (3558) embryonic GM2  (1837) embryonic Kc167  (367) embryonic S1  (1888) embryonic S3  (1973) leg disc CME L1  (2933) wing disc CME-W2  (2326) wing disc ML-DmD8  (2955) wing disc ML-DmD9  (3135) wing disc ML-DmD16-c3  (1974) wing disc ML-DmD21  (3618) wing disc ML-DmD32  (3275) haltere disc ML-DmD17-c3  (2886) eye-antennal disc ML-DmD11  (4216) antennal disc ML-DmD20-c5  (4268) mixed discs ML-DmD4-c1  (2950) CNS ML-DmBG1-c1  (2433) CNS ML-DmBG2-c2  (1616) tumorous blood cells mbn2  (1454) ovary fGS/OSS  (1833) ovary OSC  (1542) ovary OSS  (792) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    1893 Schneider line 2 Sg4    2947 embryonic 1182-4H    3558 embryonic GM2    1837 embryonic Kc167    367 embryonic S1    1888 embryonic S3    1973 leg disc CME L1    2933 wing disc CME-W2    2326 wing disc ML-DmD8    2955 wing disc ML-DmD9    3135 wing disc ML-DmD16-c3    1974 wing disc ML-DmD21    3618 wing disc ML-DmD32    3275 haltere disc ML-DmD17-c3    2886 eye-antennal disc ML-DmD11    4216 antennal disc ML-DmD20-c5    4268 mixed discs ML-DmD4-c1    2950 CNS ML-DmBG1-c1    2433 CNS ML-DmBG2-c2    1616 tumorous blood cells mbn2    1454 ovary fGS/OSS    1833 ovary OSC    1542 ovary OSS    792 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    1550 cold shock, 4-day adult    1366 heat shock, 4-day adult    1038 Cadmium 50 mM 6 hrs, larvae L3    1355 Cadmium 50 mM 12 hrs, larvae L3    1024 Cadmium 50 mM 48 hrs, 4-day adult    1144 Cadmium 100 mM 48 hrs, 4-day adult    1004 Copper 0.5 mM 12 hrs, larvae L3    1503 Copper 15 mM 48 hrs, 4-day adult    437 Zinc 5 mM 12 hrs, larvae L3    1279 Zinc 4.5 mM 48 hrs, 4-day adult    520 Ethanol 2.5% 3 hrs, larvae L3    1169 Ethanol 5% 3 hrs, larvae L3    1169 Ethanol 10% 3 hrs, larvae L3    1440 Caffeine 1.5 mg/ml 4 hrs, larvae L3    937 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    731 Caffeine 25 mg/ml 48 hrs, 4-day adult    1239 Paraquat 5 mM 48 hrs, 4-day adult    854 Paraquat 10 mM 48 hrs, 4-day adult    905 Rotenone 2 μg 12 hrs, larvae L3    1401 Rotenone 8 μg 12 hrs, larvae L3    1719 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (1550) cold shock, 4-day adult  (1366) heat shock, 4-day adult  (1038) Cadmium 50 mM 6 hrs, larvae L3  (1355) Cadmium 50 mM 12 hrs, larvae L3  (1024) Cadmium 50 mM 48 hrs, 4-day adult  (1144) Cadmium 100 mM 48 hrs, 4-day adult  (1004) Copper 0.5 mM 12 hrs, larvae L3  (1503) Copper 15 mM 48 hrs, 4-day adult  (437) Zinc 5 mM 12 hrs, larvae L3  (1279) Zinc 4.5 mM 48 hrs, 4-day adult  (520) Ethanol 2.5% 3 hrs, larvae L3  (1169) Ethanol 5% 3 hrs, larvae L3  (1169) Ethanol 10% 3 hrs, larvae L3  (1440) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (937) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (731) Caffeine 25 mg/ml 48 hrs, 4-day adult  (1239) Paraquat 5 mM 48 hrs, 4-day adult  (854) Paraquat 10 mM 48 hrs, 4-day adult  (905) Rotenone 2 μg 12 hrs, larvae L3  (1401) Rotenone 8 μg 12 hrs, larvae L3  (1719) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult  (1550) cold shock, 4-day adult  (1366) heat shock, 4-day adult  (1038) Cadmium 50 mM 6 hrs, larvae L3  (1355) Cadmium 50 mM 12 hrs, larvae L3  (1024) Cadmium 50 mM 48 hrs, 4-day adult  (1144) Cadmium 100 mM 48 hrs, 4-day adult  (1004) Copper 0.5 mM 12 hrs, larvae L3  (1503) Copper 15 mM 48 hrs, 4-day adult  (437) Zinc 5 mM 12 hrs, larvae L3  (1279) Zinc 4.5 mM 48 hrs, 4-day adult  (520) Ethanol 2.5% 3 hrs, larvae L3  (1169) Ethanol 5% 3 hrs, larvae L3  (1169) Ethanol 10% 3 hrs, larvae L3  (1440) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (937) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (731) Caffeine 25 mg/ml 48 hrs, 4-day adult  (1239) Paraquat 5 mM 48 hrs, 4-day adult  (854) Paraquat 10 mM 48 hrs, 4-day adult  (905) Rotenone 2 μg 12 hrs, larvae L3  (1401) Rotenone 8 μg 12 hrs, larvae L3  (1719) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    1550 cold shock, 4-day adult    1366 heat shock, 4-day adult    1038 Cadmium 50 mM 6 hrs, larvae L3    1355 Cadmium 50 mM 12 hrs, larvae L3    1024 Cadmium 50 mM 48 hrs, 4-day adult    1144 Cadmium 100 mM 48 hrs, 4-day adult    1004 Copper 0.5 mM 12 hrs, larvae L3    1503 Copper 15 mM 48 hrs, 4-day adult    437 Zinc 5 mM 12 hrs, larvae L3    1279 Zinc 4.5 mM 48 hrs, 4-day adult    520 Ethanol 2.5% 3 hrs, larvae L3    1169 Ethanol 5% 3 hrs, larvae L3    1169 Ethanol 10% 3 hrs, larvae L3    1440 Caffeine 1.5 mg/ml 4 hrs, larvae L3    937 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    731 Caffeine 25 mg/ml 48 hrs, 4-day adult    1239 Paraquat 5 mM 48 hrs, 4-day adult    854 Paraquat 10 mM 48 hrs, 4-day adult    905 Rotenone 2 μg 12 hrs, larvae L3    1401 Rotenone 8 μg 12 hrs, larvae L3    1719 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    1550 cold shock, 4-day adult    1366 heat shock, 4-day adult    1038 Cadmium 50 mM 6 hrs, larvae L3    1355 Cadmium 50 mM 12 hrs, larvae L3    1024 Cadmium 50 mM 48 hrs, 4-day adult    1144 Cadmium 100 mM 48 hrs, 4-day adult    1004 Copper 0.5 mM 12 hrs, larvae L3    1503 Copper 15 mM 48 hrs, 4-day adult    437 Zinc 5 mM 12 hrs, larvae L3    1279 Zinc 4.5 mM 48 hrs, 4-day adult    520 Ethanol 2.5% 3 hrs, larvae L3    1169 Ethanol 5% 3 hrs, larvae L3    1169 Ethanol 10% 3 hrs, larvae L3    1440 Caffeine 1.5 mg/ml 4 hrs, larvae L3    937 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    731 Caffeine 25 mg/ml 48 hrs, 4-day adult    1239 Paraquat 5 mM 48 hrs, 4-day adult    854 Paraquat 10 mM 48 hrs, 4-day adult    905 Rotenone 2 μg 12 hrs, larvae L3    1401 Rotenone 8 μg 12 hrs, larvae L3    1719 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (1550) cold shock, 4-day adult  (1366) heat shock, 4-day adult  (1038) Cadmium 50 mM 6 hrs, larvae L3  (1355) Cadmium 50 mM 12 hrs, larvae L3  (1024) Cadmium 50 mM 48 hrs, 4-day adult  (1144) Cadmium 100 mM 48 hrs, 4-day adult  (1004) Copper 0.5 mM 12 hrs, larvae L3  (1503) Copper 15 mM 48 hrs, 4-day adult  (437) Zinc 5 mM 12 hrs, larvae L3  (1279) Zinc 4.5 mM 48 hrs, 4-day adult  (520) Ethanol 2.5% 3 hrs, larvae L3  (1169) Ethanol 5% 3 hrs, larvae L3  (1169) Ethanol 10% 3 hrs, larvae L3  (1440) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (937) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (731) Caffeine 25 mg/ml 48 hrs, 4-day adult  (1239) Paraquat 5 mM 48 hrs, 4-day adult  (854) Paraquat 10 mM 48 hrs, 4-day adult  (905) Rotenone 2 μg 12 hrs, larvae L3  (1401) Rotenone 8 μg 12 hrs, larvae L3  (1719) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult  (1550) cold shock, 4-day adult  (1366) heat shock, 4-day adult  (1038) Cadmium 50 mM 6 hrs, larvae L3  (1355) Cadmium 50 mM 12 hrs, larvae L3  (1024) Cadmium 50 mM 48 hrs, 4-day adult  (1144) Cadmium 100 mM 48 hrs, 4-day adult  (1004) Copper 0.5 mM 12 hrs, larvae L3  (1503) Copper 15 mM 48 hrs, 4-day adult  (437) Zinc 5 mM 12 hrs, larvae L3  (1279) Zinc 4.5 mM 48 hrs, 4-day adult  (520) Ethanol 2.5% 3 hrs, larvae L3  (1169) Ethanol 5% 3 hrs, larvae L3  (1169) Ethanol 10% 3 hrs, larvae L3  (1440) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (937) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (731) Caffeine 25 mg/ml 48 hrs, 4-day adult  (1239) Paraquat 5 mM 48 hrs, 4-day adult  (854) Paraquat 10 mM 48 hrs, 4-day adult  (905) Rotenone 2 μg 12 hrs, larvae L3  (1401) Rotenone 8 μg 12 hrs, larvae L3  (1719) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    1550 cold shock, 4-day adult    1366 heat shock, 4-day adult    1038 Cadmium 50 mM 6 hrs, larvae L3    1355 Cadmium 50 mM 12 hrs, larvae L3    1024 Cadmium 50 mM 48 hrs, 4-day adult    1144 Cadmium 100 mM 48 hrs, 4-day adult    1004 Copper 0.5 mM 12 hrs, larvae L3    1503 Copper 15 mM 48 hrs, 4-day adult    437 Zinc 5 mM 12 hrs, larvae L3    1279 Zinc 4.5 mM 48 hrs, 4-day adult    520 Ethanol 2.5% 3 hrs, larvae L3    1169 Ethanol 5% 3 hrs, larvae L3    1169 Ethanol 10% 3 hrs, larvae L3    1440 Caffeine 1.5 mg/ml 4 hrs, larvae L3    937 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    731 Caffeine 25 mg/ml 48 hrs, 4-day adult    1239 Paraquat 5 mM 48 hrs, 4-day adult    854 Paraquat 10 mM 48 hrs, 4-day adult    905 Rotenone 2 μg 12 hrs, larvae L3    1401 Rotenone 8 μg 12 hrs, larvae L3    1719 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_31 mE1_20_mRNA_expression_cluster_01
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003884 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1913-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal αTub84B1 αTub84B2 αTub84B3 lethal | recessive αTub84B1 αTub84B2 αTub84B5 αTub84B6 partially lethal - majority die, with Scer\GAL4pnr-MD237 αTub84BGD9679 viable αTub84B7 viable, with Scer\GAL4nos.PG, Scer\GAL4nos.UTR.T:Hsim\VP16 αTub84BScer\UAS.P\T.T:Avic\GFP-S65C Sterility Allele female fertile | poor αTub84B7 male fertile αTub84B+t4.5 male semi-sterile (with αTub84B2) αTub84Bunspecified male semi-sterile (with αTub84B5) αTub84Bunspecified male semi-sterile (with αTub84B6) αTub84Bunspecified male semi-sterile (with αTub84B7) αTub84Bunspecified male semi-sterile (with αTub84Bunspecified) αTub84B2 αTub84B5 αTub84B6 αTub84B7 male sterile αTub84B7 male sterile | recessive αTub84B7 Other Phenotypes Allele visible, with Scer\GAL4pnr-MD237 αTub84BGD9679 wild-type αTub84B+t4.8 Phenotype manifest in Allele mesothoracic tergum, with Scer\GAL4pnr-MD237 αTub84BGD9679 spermatid αTub84Ba.βTub85D synapse & microtubule, with Scer\GAL4how-24B αTub84BScer\UAS.T:Hsap\MYC
Classical Alleles ( 9 )
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Allele of αTub84B Class Mutagen Stocks Known lesion αTub84B5 amorphic allele - genetic evidence, hypomorphic allele - genetic evidence ethyl methanesulfonate 2 -- αTub84B7 hypomorphic allele - genetic evidence ethyl methanesulfonate 2 Yes αTub84BEY02851 P-element activity 1 -- αTub84B3 amorphic allele - genetic evidence ethyl methanesulfonate 0 Yes αTub84B1 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes αTub84B2 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes αTub84B4 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 -- αTub84B6 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 -- αTub84Bunspecified 0 --
Alleles Carried on Transgenic Constructs ( 31 )
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