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Gene Dmel\αTub85E

General Information
Symbol	Dmel\αTub85E	Species	D. melanogaster
Name	α-Tubulin at 85E	Annotation symbol	CG9476
Feature type	protein_coding_gene	FlyBase ID	FBgn0003886
Gene Model Status	Current	Stock availability	2 publicly available
Also Known As	α-tubulin, Tub, α-Tub, α85E, α2
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	85E6-85E6	Sequence location	3R:5,556,943..5,558,987 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene α-Tubulin at 85E is referred to in FlyBase by the symbol Dmel\αTub85E (CG9476, FBgn0003886). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: structural constituent of cytoskeleton. There is experimental evidence that it is involved in the biological process: mitotic cell cycle spindle assembly checkpoint; cellular process; mitotic spindle organization; centrosome duplication. 5 alleles are reported. The phenotype of these alleles is annotated with: spermatid. It has one annotated transcript and one annotated polypeptide. Protein features are: Alpha tubulin; Tubulin; Tubulin, C-terminal; Tubulin, conserved site; Tubulin/FtsZ, 2-layer sandwich domain; Tubulin/FtsZ, C-terminal; Tubulin/FtsZ, GTPase domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of very low expression. Peak expression observed within 12-24 hour embryonic stages, during early larval stages, during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult testis. Comments on Affy2 ProbeSet: ProbeSet 1623910_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of alphaTub85E. Gene sequence location is 3R:5556943..5558987.
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	αTub85E (α2t) A structural gene for α-Tubulin. Only α-Tubulin not expressed maternally. Transcripts present from 6-8 hr through adult. Protein found in support cells of chordotonal organs, developing muscles, and somatic component of the testis (Matthews, Miller, and Kaufman).
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10
FB2012_01	References Müller et al., 2010, EMBO J. 29(19): 3344--3357 Meyer et al., 2011, Curr. Biol. 21(6): 485--491 Sequence features HFA16899 BKN29599 Controlled Vocabulary Terms centrosome duplication
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 85E6-85E6   Limits computationally determined from genome sequence between P{EP}CrcEP3006 and P{lacW}s2681
Experimentally Determined Cytological Location
Cytogenetic map Notes References 85E-85E   (determined by in situ hybridisation)   (Drosopoulou and Scouras, 1998) 85E6-85E10   (determined by in situ hybridisation)   (Natzle and McCarthy, 1984) 85E6-85E10   (determined by in situ hybridisation)   (Mischke and Pardue, 1982) 85E6-85E10   (determined by in situ hybridisation)   (Kalfayan and Wensink, 1981) 85E6-85E10   (determined by in situ hybridisation)   (Sanchez et al., 1980)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\αTub85E for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) αTub85E-RA FBtr0082087  NM_079573   1575   449
Additional Transcript Data & Comments
Reported size (kB)	2.049 (sequence analysis) (Theurkauf et al., 1986) 2.0, 1.8 (northern blot) (Natzle and McCarthy, 1984) 1.85, 1.65 (northern blot) (Kalfayan and Wensink, 1982) 1.55 (northern blot) (Matthews et al., 1989)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein αTub85E-PA   FBpp0081565   50.0   449   4.83     NP_524297   AAF54433
Additional Polypeptide Data & Comments
Reported size (kDa)	449 (aa); 55 (kD predicted) (Theurkauf et al., 1986)
Comments	Polypeptides were identified in wing imaginal discs and in the CME W2 wing imaginal disc cell line by 2D gel electrophoresis and by microsequencing. (Santaren et al., 1993)
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Tubulin (IPR000217) Alpha tubulin (IPR002452) Tubulin/FtsZ, GTPase domain (IPR003008) Tubulin/FtsZ, C-terminal (IPR008280) Tubulin, conserved site (IPR017975) Tubulin/FtsZ, 2-layer sandwich domain (IPR018316) Tubulin, C-terminal (IPR023123)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA979650   AE014297 AAF54433   AI295451   AI944857   AI946623   AK278735   AK281777   AK282586   AY084208   AY113631 AAM29636   AY231787   AY432371   BE978409   BF485571   BF489482   BF495372   BF495746   BF497424   BF500552   BF503401   BF504060   BI165568   BI167088   BI213816   BI236732   BI239011   BI240461   BI240899   BI240922   BI240981   BI240983   BI356315   BI368579   BI374066   BI374963   BI482869   BI578815   BI580417   BI605864   BT003630   BT012506   BT016118   BT044334   BX005570   BX006068   BX006881   BX007023   BX007757   BX007996   BX009126   BX009302   BX011538   BX014125   BX015446   BX015701   BX016319   BX016721   BX017052   BX018244   BX019574   BX020136   BX020289   BX020626   BX020651   BX020705   BX021167   BX022058   BX022214   BX023695   BX024048   BX024443   BX026450   BX026755   BX026827   BX028325   BX029668   BX029685   BX029728   BX030828   BX031517   BX032230   BX033080   BX034162   BX034268   BX034454   BX037080   BX038833   BX041328   BX043013   BX044536   BX047470   BX050483   BX051458   BX053542   BX054934   BX056074   BX056628   BX057344   BX060127   BX061026   BX061199   BX062157   BX063462   BX064928   BX065134   BX066139   BX067109   BX067643   BX068310   BX069757   BX070179   BX071989   BX072076   CO312800   CR938635   DQ440241   DQ675550   EC065044   EF207983   GH749019   GH749596   GH751617   GH771349   GH772029   GH772223   GH774730   GH776376   GH776821   GH778163   GH780804   GH780881   GH781132   GH781519   GH783734   GH784451   GH788392   GH789296   GH789685   GH790054   GH792512   GH794792   GH794801   GH794866   GH799053   GH799203   GH799635   GH801959   GH802197   GH803254   GH803293   GH803307   GH803912   GH808435   GH810048   GH811385   GH816497   GH816782   GH817191   GH817698   GH818080   GH821050   GH821821   GH822346   GH822889   GH824944   GH825064   GH826344   GH828876   GH829447   GH832364   GH832422   GH833191   GH833802   GH834034   GH835391   GH839277   GH841878   GH842499   GH842982   GH843672   GH843958   GH846182   GH846684   GH847202   GH847372   GH849578   GH849679   GH853535   GH855184   GH855699   GH858155   GH858247   GH858989   GH859615   GH861317   GH861579   GH861905   GH861937   GH863407   GH865572   GH866193   GH866787   GH867033   GH867264   GH869614   GH870299   GH871090   GH871584   GH874747   GH874810   GH874872   GH876672   GH876916   GH878410   GH880509   GH882696   GH885169   GH891486   GH892872   GH893601   GH894177   GH895149   GH895414   GH895749   GH897079   GH898479   GH900460   GH903714   GH904547   GH904728   GH905298   GH905746   GH907928   GH908769   GH909318   GH909749   GH909829   GH910117   GH910956   GH911864   GH912860   GH915000   GH915265   GH917491   GH918167   GH918856   GH919229   GH920223   GH920230   GH921216   GH924174   GH929577   GH930783   GH931101   GH932157   GH935123   GH936835   GH938945   GH940515   GH940814   GH941090   M14644 AAA28986
UniProtKB/Swiss-Prot	P06604
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference   organism   (Matthews et al., 1989) Comment:reference states 8-12 hr AEL northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 11     (Natzle and McCarthy, 1984) Comment:reference states 0-6 hr AEL embryonic stage 4 -- 17     (Natzle and McCarthy, 1984) Comment:reference states 2-21 hr AEL embryonic stage 11 -- 15     (Kalfayan and Wensink, 1982) Comment:reference states 6-12 hr AEL larval stage     (Kalfayan and Wensink, 1982) larval stage -- pupal stage     (Matthews et al., 1989) first instar larval stage     (Natzle and McCarthy, 1984) second instar larval stage     (Natzle and McCarthy, 1984) third instar larval stage     (Natzle and McCarthy, 1984) prepupal stage     (Natzle and McCarthy, 1984) pupal stage     (Kalfayan and Wensink, 1982, Natzle and McCarthy, 1984) adult stage | male     (Kalfayan and Wensink, 1982) spermatogenesis & adult stage   testis   (Matthews et al., 1989)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference third instar larval stage   wing disc   (Santaren et al., 1993) immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage 13 -- first instar larval stage   scolopidial dendritic cap cell | subset   (Inbal et al., 2004) first instar larval stage   scolopidial ligament cell | subset   (Inbal et al., 2004) western blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage 17     (Matthews et al., 1989) Comment:reference states 16-20 hr AEL larval stage   imaginal disc   (Matthews et al., 1989) spermatogenesis & adult stage   testis   (Matthews et al., 1989)
Additional Descriptive Data
	To compare synthesis and accumulation of α-tubulin proteins, 35S</up>methionine radiolabeled tissues were subjected to Western analysis using monoclonal anti-α-tubulin antibody. Newly synthesized αTub85E protein was observed possibly in testes and imaginal disc tissue, but a stable pool was observed only in late embryos. (Matthews et al., 1989)
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0003886    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0003886 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of very low expression. Peak expression observed within 12-24 hour embryonic stages, during early larval stages, during early pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0003886 expression level Developmental Stage   Expression Level embryo 00-02hr    44 embryo 02-04hr    55 embryo 04-06hr    59 embryo 06-08hr    362 embryo 08-10hr    752 embryo 10-12hr    5353 embryo 12-14hr    5328 embryo 14-16hr    11335 embryo 16-18hr    10033 embryo 18-20hr    12580 embryo 20-22hr    10128 embryo 22-24hr    8504 larva L1    10569 larva L2    8954 larva L3 12hr old    6084 larva L3 puffstage 1-2    2458 larva L3 puffstage 3-6    3019 larva L3 puffstage 7-9    2877 white prepupae new    2357 white prepupae 12hr    3060 white prepupae 24hr    11385 pupae 2d postWPP    6711 pupae 3d postWPP    4928 pupae 4d postWPP    3585 adult male 01day    2963 adult male 05day    2696 adult male 30day    2713 adult female 01day    489 adult female 05day    54 adult female 30day    37 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    44 embryo 02-04hr    55 embryo 04-06hr    59 embryo 06-08hr  (362) embryo 08-10hr  (752) embryo 10-12hr  (5353) embryo 12-14hr  (5328) embryo 14-16hr  (11335) embryo 16-18hr  (10033) embryo 18-20hr  (12580) embryo 20-22hr  (10128) embryo 22-24hr  (8504) larva L1  (10569) larva L2  (8954) larva L3 12hr old  (6084) larva L3 puffstage 1-2  (2458) larva L3 puffstage 3-6  (3019) larva L3 puffstage 7-9  (2877) white prepupae new  (2357) white prepupae 12hr  (3060) white prepupae 24hr  (11385) pupae 2d postWPP  (6711) pupae 3d postWPP  (4928) pupae 4d postWPP  (3585) adult male 01day  (2963) adult male 05day  (2696) adult male 30day  (2713) adult female 01day  (489) adult female 05day    54 adult female 30day    37 Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    44 embryo 02-04hr    55 embryo 04-06hr    59 embryo 06-08hr    362 embryo 08-10hr    752 embryo 10-12hr  (5353) embryo 12-14hr  (5328) embryo 14-16hr  (11335) embryo 16-18hr  (10033) embryo 18-20hr  (12580) embryo 20-22hr  (10128) embryo 22-24hr  (8504) larva L1  (10569) larva L2  (8954) larva L3 12hr old  (6084) larva L3 puffstage 1-2  (2458) larva L3 puffstage 3-6  (3019) larva L3 puffstage 7-9  (2877) white prepupae new  (2357) white prepupae 12hr  (3060) white prepupae 24hr  (11385) pupae 2d postWPP  (6711) pupae 3d postWPP  (4928) pupae 4d postWPP  (3585) adult male 01day  (2963) adult male 05day  (2696) adult male 30day  (2713) adult female 01day    489 adult female 05day    54 adult female 30day    37 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    44 embryo 02-04hr    55 embryo 04-06hr    59 embryo 06-08hr    362 embryo 08-10hr    752 embryo 10-12hr    5353 embryo 12-14hr    5328 embryo 14-16hr  (11335) embryo 16-18hr  10033 embryo 18-20hr  (12580) embryo 20-22hr  10128 embryo 22-24hr    8504 larva L1  10569 larva L2    8954 larva L3 12hr old    6084 larva L3 puffstage 1-2    2458 larva L3 puffstage 3-6    3019 larva L3 puffstage 7-9    2877 white prepupae new    2357 white prepupae 12hr    3060 white prepupae 24hr  (11385) pupae 2d postWPP    6711 pupae 3d postWPP    4928 pupae 4d postWPP    3585 adult male 01day    2963 adult male 05day    2696 adult male 30day    2713 adult female 01day    489 adult female 05day    54 adult female 30day    37 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    44 embryo 02-04hr    55 embryo 04-06hr    59 embryo 06-08hr    362 embryo 08-10hr    752 embryo 10-12hr    5353 embryo 12-14hr    5328 embryo 14-16hr    11335 embryo 16-18hr    10033 embryo 18-20hr    12580 embryo 20-22hr    10128 embryo 22-24hr    8504 larva L1    10569 larva L2    8954 larva L3 12hr old    6084 larva L3 puffstage 1-2    2458 larva L3 puffstage 3-6    3019 larva L3 puffstage 7-9    2877 white prepupae new    2357 white prepupae 12hr    3060 white prepupae 24hr    11385 pupae 2d postWPP    6711 pupae 3d postWPP    4928 pupae 4d postWPP    3585 adult male 01day    2963 adult male 05day    2696 adult male 30day    2713 adult female 01day    489 adult female 05day    54 adult female 30day    37 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0003886 expression level Developmental Stage   Expression Level embryo 00-02hr    44 embryo 02-04hr    55 embryo 04-06hr    59 embryo 06-08hr    362 embryo 08-10hr    752 embryo 10-12hr    5353 embryo 12-14hr    5328 embryo 14-16hr    11335 embryo 16-18hr    10033 embryo 18-20hr    12580 embryo 20-22hr    10128 embryo 22-24hr    8504 larva L1    10569 larva L2    8954 larva L3 12hr old    6084 larva L3 puffstage 1-2    2458 larva L3 puffstage 3-6    3019 larva L3 puffstage 7-9    2877 white prepupae new    2357 white prepupae 12hr    3060 white prepupae 24hr    11385 pupae 2d postWPP    6711 pupae 3d postWPP    4928 pupae 4d postWPP    3585 adult male 01day    2963 adult male 05day    2696 adult male 30day    2713 adult female 01day    489 adult female 05day    54 adult female 30day    37 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    44 embryo 02-04hr    55 embryo 04-06hr    59 embryo 06-08hr  (362) embryo 08-10hr  (752) embryo 10-12hr  (5353) embryo 12-14hr  (5328) embryo 14-16hr  (11335) embryo 16-18hr  (10033) embryo 18-20hr  (12580) embryo 20-22hr  (10128) embryo 22-24hr  (8504) larva L1  (10569) larva L2  (8954) larva L3 12hr old  (6084) larva L3 puffstage 1-2  (2458) larva L3 puffstage 3-6  (3019) larva L3 puffstage 7-9  (2877) white prepupae new  (2357) white prepupae 12hr  (3060) white prepupae 24hr  (11385) pupae 2d postWPP  (6711) pupae 3d postWPP  (4928) pupae 4d postWPP  (3585) adult male 01day  (2963) adult male 05day  (2696) adult male 30day  (2713) adult female 01day  (489) adult female 05day    54 adult female 30day    37 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    44 embryo 02-04hr    55 embryo 04-06hr    59 embryo 06-08hr    362 embryo 08-10hr    752 embryo 10-12hr  (5353) embryo 12-14hr  (5328) embryo 14-16hr  (11335) embryo 16-18hr  (10033) embryo 18-20hr  (12580) embryo 20-22hr  (10128) embryo 22-24hr  (8504) larva L1  (10569) larva L2  (8954) larva L3 12hr old  (6084) larva L3 puffstage 1-2  2458 larva L3 puffstage 3-6  (3019) larva L3 puffstage 7-9  (2877) white prepupae new  2357 white prepupae 12hr  (3060) white prepupae 24hr  (11385) pupae 2d postWPP  (6711) pupae 3d postWPP  (4928) pupae 4d postWPP  (3585) adult male 01day  (2963) adult male 05day  (2696) adult male 30day  (2713) adult female 01day    489 adult female 05day    54 adult female 30day    37 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    44 embryo 02-04hr    55 embryo 04-06hr    59 embryo 06-08hr    362 embryo 08-10hr    752 embryo 10-12hr    5353 embryo 12-14hr    5328 embryo 14-16hr  11335 embryo 16-18hr  10033 embryo 18-20hr  12580 embryo 20-22hr  10128 embryo 22-24hr    8504 larva L1  10569 larva L2    8954 larva L3 12hr old    6084 larva L3 puffstage 1-2    2458 larva L3 puffstage 3-6    3019 larva L3 puffstage 7-9    2877 white prepupae new    2357 white prepupae 12hr    3060 white prepupae 24hr  11385 pupae 2d postWPP    6711 pupae 3d postWPP    4928 pupae 4d postWPP    3585 adult male 01day    2963 adult male 05day    2696 adult male 30day    2713 adult female 01day    489 adult female 05day    54 adult female 30day    37 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    44 embryo 02-04hr    55 embryo 04-06hr    59 embryo 06-08hr    362 embryo 08-10hr    752 embryo 10-12hr    5353 embryo 12-14hr    5328 embryo 14-16hr    11335 embryo 16-18hr    10033 embryo 18-20hr    12580 embryo 20-22hr    10128 embryo 22-24hr    8504 larva L1    10569 larva L2    8954 larva L3 12hr old    6084 larva L3 puffstage 1-2    2458 larva L3 puffstage 3-6    3019 larva L3 puffstage 7-9    2877 white prepupae new    2357 white prepupae 12hr    3060 white prepupae 24hr    11385 pupae 2d postWPP    6711 pupae 3d postWPP    4928 pupae 4d postWPP    3585 adult male 01day    2963 adult male 05day    2696 adult male 30day    2713 adult female 01day    489 adult female 05day    54 adult female 30day    37 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0003886    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0003886 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult testis. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0003886 expression level Tissue   Expression Level Larval Central Nervous System    5.175 Larval Midgut    2.2 Larval Hindgut no informative data Larval Malpighian Tubules    4.2 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    43 Larval Carcass    512.15 Adult Head    7.1 Adult Eye    3.6 Adult Brain    4.1 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut    2.5 Adult Hindgut    2.5 Adult Malpighian Tubules    2.8 Adult Fat Body    8.1 Adult Salivary Gland    8.4 Adult Heart    1.825 Adult VirginFemale Spermatheca    6.8 Adult InseminatedFemale Spermatheca    3.9 Adult Ovary    4.9 Adult Testis    361.6 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    5.175 Larval Midgut    2.2 Larval Hindgut no informative data Larval Malpighian Tubules    4.2 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    43 Larval Carcass  512.15 Adult Head    7.1 Adult Eye    3.6 Adult Brain    4.1 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut    2.5 Adult Hindgut    2.5 Adult Malpighian Tubules    2.8 Adult Fat Body    8.1 Adult Salivary Gland    8.4 Adult Heart    1.825 Adult VirginFemale Spermatheca    6.8 Adult InseminatedFemale Spermatheca    3.9 Adult Ovary    4.9 Adult Testis    361.6 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    5.175 Larval Midgut    2.2 Larval Hindgut no informative data Larval Malpighian Tubules    4.2 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    43 Larval Carcass    512.15 Adult Head    7.1 Adult Eye    3.6 Adult Brain    4.1 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut    2.5 Adult Hindgut    2.5 Adult Malpighian Tubules    2.8 Adult Fat Body    8.1 Adult Salivary Gland    8.4 Adult Heart    1.825 Adult VirginFemale Spermatheca    6.8 Adult InseminatedFemale Spermatheca    3.9 Adult Ovary    4.9 Adult Testis    361.6 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    5.175 Larval Midgut    2.2 Larval Hindgut no informative data Larval Malpighian Tubules    4.2 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    43 Larval Carcass    512.15 Adult Head    7.1 Adult Eye    3.6 Adult Brain    4.1 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut    2.5 Adult Hindgut    2.5 Adult Malpighian Tubules    2.8 Adult Fat Body    8.1 Adult Salivary Gland    8.4 Adult Heart    1.825 Adult VirginFemale Spermatheca    6.8 Adult InseminatedFemale Spermatheca    3.9 Adult Ovary    4.9 Adult Testis    361.6 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0003886 expression level Tissue   Expression Level Larval Central Nervous System    5.175 Larval Midgut    2.2 Larval Hindgut no informative data Larval Malpighian Tubules    4.2 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    43 Larval Carcass    512.15 Adult Head    7.1 Adult Eye    3.6 Adult Brain    4.1 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut    2.5 Adult Hindgut    2.5 Adult Malpighian Tubules    2.8 Adult Fat Body    8.1 Adult Salivary Gland    8.4 Adult Heart    1.825 Adult VirginFemale Spermatheca    6.8 Adult InseminatedFemale Spermatheca    3.9 Adult Ovary    4.9 Adult Testis    361.6 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    5.175 Larval Midgut    2.2 Larval Hindgut no informative data Larval Malpighian Tubules    4.2 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    43 Larval Carcass  512.15 Adult Head    7.1 Adult Eye    3.6 Adult Brain    4.1 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut    2.5 Adult Hindgut    2.5 Adult Malpighian Tubules    2.8 Adult Fat Body    8.1 Adult Salivary Gland    8.4 Adult Heart    1.825 Adult VirginFemale Spermatheca    6.8 Adult InseminatedFemale Spermatheca    3.9 Adult Ovary    4.9 Adult Testis    361.6 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    5.175 Larval Midgut    2.2 Larval Hindgut no informative data Larval Malpighian Tubules    4.2 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    43 Larval Carcass    512.15 Adult Head    7.1 Adult Eye    3.6 Adult Brain    4.1 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut    2.5 Adult Hindgut    2.5 Adult Malpighian Tubules    2.8 Adult Fat Body    8.1 Adult Salivary Gland    8.4 Adult Heart    1.825 Adult VirginFemale Spermatheca    6.8 Adult InseminatedFemale Spermatheca    3.9 Adult Ovary    4.9 Adult Testis    361.6 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    5.175 Larval Midgut    2.2 Larval Hindgut no informative data Larval Malpighian Tubules    4.2 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    43 Larval Carcass    512.15 Adult Head    7.1 Adult Eye    3.6 Adult Brain    4.1 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut    2.5 Adult Hindgut    2.5 Adult Malpighian Tubules    2.8 Adult Fat Body    8.1 Adult Salivary Gland    8.4 Adult Heart    1.825 Adult VirginFemale Spermatheca    6.8 Adult InseminatedFemale Spermatheca    3.9 Adult Ovary    4.9 Adult Testis    361.6 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut no informative data Larval Malpighian Tubules     Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland no informative data Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    7.1   NA  Eye    3.6   NA  Brain    4.1   5.175  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    no informative data   NA  Crop    no informative data   2.2  Midgut    2.5   no informative data  Hindgut    2.5   4.2  Malpighian Tubules    2.8   no informative data  Fat Body    8.1   no informative data  Salivary Gland    8.4   NA  Heart    1.825   43  Trachea    NA   NA  VirginFemale Spermatheca    6.8   NA  InseminatedFemale Spermatheca    3.9   NA  Ovary    4.9   NA  Testis    361.6   NA  Male Accessory Gland    no informative data   512.15  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_29
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003886 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9476-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Sterility Allele male fertile αTub85EβTub85D.PH Phenotype manifest in Allele spermatid αTub85EβTub85D.PH
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of αTub85E Class Mutagen Stocks Known lesion αTub85Eunspecified 0 --
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of αTub85E Class Mutagen Stocks Known lesion αTub85EHM04009 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes αTub85EKK109599 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes αTub85EGD14226 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes αTub85EβTub85D.PH in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)by10 (Seshaiah et al., 2001) Df(3R)GB104 (Seshaiah et al., 2001) Tp(3;2)by62 (Seshaiah et al., 2001)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data reporter construct P{Tα2-lacZ.1} No P{Tα2-lacZ.2} No
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 13 unique terms )
Terms Based on Experimental Evidence ( 4 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
cellular process inferred from mutant phenotype (Boutros et al., 2004) centrosome duplication inferred from mutant phenotype (Müller et al., 2010) mitotic cell cycle spindle assembly checkpoint inferred from direct assay (Logarinho et al., 2004) mitotic spindle organization inferred from mutant phenotype (Goshima et al., 2007)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 9 terms )
Molecular Function
CV term Evidence References
GTPase activity inferred from electronic annotation with InterPro:IPR008280, InterPro:IPR018316 (FlyBase Curators et al., 2004-) GTP binding inferred from electronic annotation with InterPro:IPR000217, InterPro:IPR002452, InterPro:IPR008280, InterPro:IPR017975, InterPro:IPR018316 (FlyBase Curators et al., 2004-) non-traceable author statement (Swiss-Prot Project Members, 1988.1.1) structural constituent of cytoskeleton inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000) structural molecule activity inferred from electronic annotation with InterPro:IPR002452 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
GTP catabolic process inferred from electronic annotation with InterPro:IPR008280, InterPro:IPR018316 (FlyBase Curators et al., 2004-) microtubule-based movement inferred from electronic annotation with InterPro:IPR002452 (FlyBase Curators et al., 2004-) protein polymerization inferred from electronic annotation with InterPro:IPR003008, InterPro:IPR008280, InterPro:IPR018316 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
microtubule inferred from electronic annotation with InterPro:IPR000217, InterPro:IPR002452, InterPro:IPR017975 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000) non-traceable author statement (Swiss-Prot Project Members, 1988.1.1) tubulin complex non-traceable author statement (Swiss-Prot Project Members, 1988.1.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions αTub85E allele Gene References αTub85EβTub85D.PH βTub85D (Hoyle et al., 2001)
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0003886 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41183
Orthologs
Genome-wide drosophilid orthologs	Dana\GF11529 Dere\GG17337 Dmoj\GI23620 Dsec\GM26223 Dsim\GD20767 Dyak\GE24741
Curated drosophilid orthologs	Daur\αTub85E   Dbio\αTub85E   Djam\αTub85E   Dmau\αTub85E (Zeng et al., 2000) Dpse\GA21818   Dseg\αTub85E   Dser\αTub85E   Dsim\αTub85E (Zeng et al., 2000)
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL012101-PA Aedes aegypti (mosquito) CAL0004511 Candida albicans (a form of yeast) CPIJ011550 Culex pipens (mosquito) DDB0191380 Dictyostelium discoideum (amoeba) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0241845 FBgn0192232 FBgn0181078 FBgn0109564 FBgn0088569
Stocks & Reagents
Stocks Listed in FlyBase ( 2 )
Bloomington	31703 y1 v1; P{TRiP.HM04009}attP2
VDRC	v103202 P{KK109599}VIE-260B
Genomic Clones ( 2 )
	BACR23O04 BACR30F01 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 178 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT25469 AT26363 LD07757 RH71862 SD07763
Other clones	FI07460 yak-em_alphaTub84B
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT04207 AT05341 AT09392 AT11589 AT15535 AT19377 AT19611 AT25436 RE05488 RE07384 RE19425 RE32839 RE35390 RE37310 RE37856 RE37881 RE37950 RE37952 RE42430 RE54572 RE61578 RE62660 RE65657 RE72744 RE74610
Other clones	bs06c05 bs28h03 bs78d07 EK229987 RP003036370 RP003037110 RP003043364 RP003046276 RP003059319 RP003063709 RP003067221 RP003068767 RP003071426 RP003073335 RP003074961 RP003087155 RP003087918 RP003088227 RP003097436 RP003101992 RP003103838 RP003103902 RP003115741 RP003118720 RP003120683 RP003122603 RP003129829 RP003130213 RP003134904 RP003135973 RP003146366 RP003149199 RP003151288 RP003157867 RP003158849 RP003159328 RP003159776 RP003163787 RP003175554 RP003175584 RP003176614 RP003182294 RP003183718 RP003186955 RP003193454 RP003194954 RP003199190 RP003201905 RP003202456 RP003202502 RP003204618 RP003211442 RP003224148 RP003228390 RP003228579 RP003231642 RP003233190 RP003236734 RP003240840 RP003251293 RP003263175 RP003265545 RP003266693 RP003268901 RP003272266 RP003274311 RP003278150 RP003279464 RP003282422 RP003282655 RP003283028 RP003286970 RP003292827 RP003293981 RP003296851 RP003298479 RP003298511 RP003309979 RP003312224 RP003316646 RP003331044 RP003331855 RP003332675 RP003342080 RP003346844 RP003348811 RP003349525 RP003352163 RP003392793 RP003394228 RP003402272 RP003408333 RP003421264 RP003425639 RP003431032 RP003451230 RP003457731 RP003459119 RP003462197 RP003464808 RP003464831 RP003470550 RP003478964 RP003479624 RP003484079 RP003504050 RP003516950 RP003521879 RP003532774 RP003543171 RP003544190 RP003552134 RP003555964 RP003556787 RP003556932 RP003571526 RP003586526 RP003587454 RP003588016 RP003591857 RP003604269 RP003605774 RP003610647 RP003616858 RP003617751 RP003624108 RP003626035 RP003629525 RP003629940 RP003635675 RP003636476 RP003640976 RP003642338 RP003650673 RP003654970 RP003655323 RP003655394 RP003662009 RP003664677 RP003665428 RP003667382 RP003669747 RP003672460 RP003672531 RP003673469 RP003674328
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0003886 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41183
Antibody Information
	polyclonal (Klein et al., 2010)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	RNAi screen using dsRNA made from templates generated with primers directed against this gene in S2 cell results in dim staining of microtubules, and a short monopolar spindle. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA. (Goshima et al., 2007) RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells. (Boutros et al., 2004) RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells. (Boutros et al., 2004) In a sample of 79 genes with multiple introns, 33 showed significant heterogeneity in G+C content among introns of the same gene and significant positive correspondence between the intron and the third codon position G+C content within genes. These results are consistent with selection acting against preferred codons at the start of genes. (Kliman and Eyre-Walker, 1998) Though αTub84B and αTub85E are very similar in sequence they are functionally distinct. αTub85E can provide function in the male germ line fr generic microtubule arrays but lacks a subset of the functional properties possessed by necessary for specific features of microtubule assembly unique to the male germ cells. (Hutchens et al., 1997) Identified in 2D gels of CMW W2 wing imaginal disc cell proteins. (Santaren et al., 1993) The tissue specific pattern of αTub85E protein accumulation is identified by isotope specific antibody. (Matthews et al., 1990) The expression of βTub60D is accompanied by a coordinate transient increase in the level of synthesis of the embryonic α-tubulins, thereby maintaining an approximately equimolar synthesis of α- and β-tubulins throughout embryogenesis. (Raff et al., 1982) In D.melanogaster, two multigene families, each made up of four members, code for α- and β-tubulins. Tubulins are a highly conserved family of proteins that are the main structural components of microtubules in mitotic and meiotic spindles, cilia, flagella, neural processes and the cytoskeleton; nontubulin proteins (MAPS or microtubule-associated proteins) are involved along with tubulins in the formation of specialized microtubules (FBrf0045282; FBrf0046966). αTub85E is the only α-tubulin not expressed maternally. Transcripts present from 6-8 hr through adult. Protein found in support cells of chordotonal organs, developing muscles and somatic component of the testis (FBrf0049502). In adults expression of αTub85E is male-specific (FBrf0045282).
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079573 RefSeq (Proteins) • NP_524297 DDBJ / EMBL / GenBank • AA979650 AAA28986 AAF54433 AAM29636 AI295451 AI944857 AI946623 AY113631 BI605864 M14644 Entrez Gene - A searchable database of RefSeq genes. • 41183 UniProtKB/Swiss-Prot • P06604
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Tubulin (IPR000217) Alpha tubulin (IPR002452) Tubulin/FtsZ, GTPase domain (IPR003008) Tubulin/FtsZ, C-terminal (IPR008280) Tubulin, conserved site (IPR017975) Tubulin/FtsZ, 2-layer sandwich domain (IPR018316) Tubulin, C-terminal (IPR023123)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0003886 DRSC - Results from RNAi screens. • FBgn0003886 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003886 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9476-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0003886 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41183 InParanoid A subset of ortholog calls from InParanoid. • AAEL012101-PA Aedes aegypti (mosquito) CAL0004511 Candida albicans (a form of yeast) CPIJ011550 Culex pipens (mosquito) DDB0191380 Dictyostelium discoideum (amoeba) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41183 modMine - Data generated by the modENCODE project. • FBgn0003886 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0241845 FBgn0192232 FBgn0181078 FBgn0109564 FBgn0088569
Synonyms & Secondary IDs ( 32 )
Reported As
Symbol Synonym	2t (Fyrberg and Goldstein, 1990) a2t (Fuller, 1993) ALPHA 85E (Goldstein and Gunawardena, 2000) alphaTub85E (Müller et al., 2010) aTub85E (Kliman and Eyre-Walker, 1998) CG9476 (Goldstein and Gunawardena, 2000, Goshima et al., 2007, Keleman et al., 2009.8.5, Wertheim et al., 2005, Ni et al., 2008) DTA3 (Natzle and McCarthy, 1984) T (Courgeon et al., 1993) Tub (Wei et al., 2004, Harris and Peifer, 2004) α2 (Drosopoulou and Scouras, 1998, Bo and Wensink, 1989) α2t   α85E (Hoyle et al., 2001, Raff, 1984) α85E-tub (Inbal et al., 2004) α-Tub (Ruel et al., 2003, Fichelson et al., 2010) αTub (Audibert et al., 2005) αTub2 (Mansfield et al., 1994, ) αTub84E (Moritz, 1993) α-Tub85E (Klein et al., 2010) αTub85E (Goshima et al., 2007, Weake et al., 2011, Wertheim et al., 2005, Sharma et al., 2011) α-tubulin (Martinez-Campos et al., 2004, Wasser and Chia, 2003, Maiato et al., 2006)
Name Synonym	alpha-tubulin (Przewloka et al., 2007) tubulin (Harris and Peifer, 2004, Galindo et al., 2007, Harris and Peifer, 2005, Goshima et al., 2005, Ashley et al., 2005, Yuen et al., 2008) α2-tubulin (Bo and Wensink, 1989) α2tubulin (Raff et al., 1982) α85E-tubulin (Dettman et al., 2001) αT (Galindo et al., 2007) α-Tubulin (Wei et al., 2004, Betschinger et al., 2005, Berdnik and Knoblich, 2002, van Steensel et al., 2001, Brandt et al., 2006, Szafranski and Goode, 2007, Fichelson et al., 2010) α-tubulin (Kwon and Scholey, 2004, Cottam et al., 2004, Fuse et al., 2003, Betschinger et al., 2003, Mollinari et al., 2002, Sampaio et al., 2001, Bellaiche et al., 2001, Wakefield et al., 2001, Walker et al., 2000, Ben-Yaacov et al., 2001, Leismann et al., 2000, Roos et al., 2000, Lemos et al., 2000, Lange et al., 2000, Wilson, 1999, Wilson, 1999, Gho et al., 1999, Herrmann et al., 1998, Kuchinke et al., 1998, Riparbelli et al., 1997, Eaton et al., 1996, Brill et al., 1995, Endow et al., 1994, Callaini et al., 1994, Baker et al., 1993, Wu et al., 1990, Logarinho et al., 2004, Cenci et al., 2003, Somma et al., 2003, Roper and Brown, 2004, Mendjan et al., 2006, Verollet et al., 2006, Goshima et al., 2007, Wilson, 2005, McHugh et al., 2004, Murray and Saint, 2007, Ohlstein and Spradling, 2007, Rujano et al., 2006, Sakaguchi and Steward, 2007, Meignin et al., 2004, Cullen et al., 2005, Cheng et al., 2008, Holtzman et al., 2008, Gao et al., 2008, Wang et al., 2007, Zhang et al., 2009, Kner et al., 2009, Brandt, 2006, Bucciarelli et al., 2009) αtubulin (Battaglia et al., 2001, Grieder and Spradling, 1999) α tubulin (Donaldson et al., 2001, Audibert and Simonelig, 1999, Nicolai et al., 1999, Avides and Glover, 1999, Bonaccorsi et al., 1998, Abdu et al., 2006) α-Tubulin 85E (O'Farrell and Kylsten, 2008) α-tubulin 85E (Cachero et al., 2011) α-Tubulin at 85E
Secondary FlyBase IDs
References ( 151 )
Generate a list of	All references relating to this gene ( 151 )
List References by type	Research paper  ( 119 ) Supplementary material  ( 8 ) Review  ( 8 ) Personal communication to FlyBase  ( 3 ) Abstract  ( 6 ) Letter  ( 1 ) Protein sequence record  ( 1 ) Computer file  ( 1 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 ) Book  ( 1 )
Recent research papers ( 7 )
	Cachero et al., 2011, PLoS Biol. 9(1): e1000568 The gene regulatory cascade linking proneural specification with differentiation in Drosophila sensory neurons. [FBrf0212891] Meyer et al., 2011, Curr. Biol. 21(6): 485--491 Interkinetic nuclear migration is a broadly conserved feature of cell division in pseudostratified epithelia. [FBrf0213254] Sharma et al., 2011, Chemosphere 82(3): 370--376 Transcriptome analysis provides insights for understanding the adverse effects of endosulfan in Drosophila melanogaster. [FBrf0212610] Weake et al., 2011, Genes Dev. 25(14): 1499--1509 Post-transcription initiation function of the ubiquitous SAGA complex in tissue-specific gene activation. [FBrf0214372] Fichelson et al., 2010, Development 137(5): 815--824 lethal giant larvae is required with the par genes for the early polarization of the Drosophila oocyte. [FBrf0209930] Klein et al., 2010, Dev. Biol. 337(2): 458--470 The proprioceptive and contractile systems in Drosophila are both patterned by the EGR family transcription factor Stripe. [FBrf0209777] Müller et al., 2010, EMBO J. 29(19): 3344--3357 Proteomic and functional analysis of the mitotic Drosophila centrosome. [FBrf0212030] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...