Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\tuh1 using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\tuh1 in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
A third chromosome EMS-induced mutant I127, when homozygous or when heterozygous over Abd-Biab9-tuh-3, produces head abnormalities involving genital and abdominal transformations under the influence of the tuh1 maternal effect.
Approximately 7% of females from the tumorous head (CT) strain have abnormal thoracic appendages (mostly metathoracic) ranging from missing to duplicated structures. These defects are dependent on genes in the first and third chromosomes, consistent with tuh1 and Abd-Biab9-tuh-3 being involved.
The other type of abnormality occurring in tumorous head stocks involves genital disc defects that result in missing or undeveloped testes and associated organs, both in males and in transformed females.
Modifiers on the first, second and third chromosomes in certain lines likewise increase the maternal effect of tuh1.
Penetrance of these head abnormalities is increased by high temperature during oogenesis and early embryogenesis.
In the mutant larvae, patches of aldehyde oxidase positive tissue can be demonstrated within the aldehyde oxidase negative eye discs, where, presumably, transformed tissue will occur.
Viability of stocks showing head abnormalities is about 70%; lethality may occur in the egg, larval, or pupal periods.
Penetrance of these head abnormalities is increased by the presence of E(tuh1) an enhancer of the mutant phenotype on 3R.
There seems to be an interaction involving maternal effect substances between tuh1 (or tuh1+) and Abd-Biab9-tuh-3, an allele of the most distal gene in the BXC; the homoeotic effects of homo- or heterozygous Abd-Biab9-tuh-3 flies are strongly enhanced by the tuh1 allele. One type of abnormality in tumorous head mutants involves homoeotic changes, deficiencies and duplications in the eye, antenna, or rostralhaut regions that transform parts of these structures into tergite-like, leg-like, or genital-like growths in the adult.
Penetrance of these head abnormalities is increased by high temperature during oogenesis and early embryogenesis. Modifiers on the first, second and third chromosomes in certain lines likewise increase the maternal effect of tuh1.
Maternal effect gene with no phenotypic expression of its own; presence of gene indicated by difference in results obtained from reciprocal crosses between phenotypically tumorous head and inbred wild-type flies, the mutant phenotype only appearing in the offspring when the mother comes from the tuh stock.