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Gene Dmel\tup

General Information
Symbol	Dmel\tup	Species	D. melanogaster
Name	tailup	Annotation symbol	CG10619
Feature type	protein_coding_gene	FlyBase ID	FBgn0003896
Gene Model Status	Current	Stock availability	12 publicly available
Also Known As	isl, islet
Genomic Location
Chromosome (arm)	2L	Recombination map	2-53.9
Cytogenetic map	37B1-37B1	Sequence location	2L:18,859,500..18,881,256 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene tailup is referred to in FlyBase by the symbol Dmel\tup (CG10619, FBgn0003896). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: RNA polymerase II regulatory region sequence-specific DNA binding; protein binding; RNA polymerase II distal enhancer sequence-specific DNA binding; sequence-specific distal enhancer binding RNA polymerase II transcription factor activity; RNA polymerase II activating transcription factor binding. There is experimental evidence for 15 unique biological process terms, many of which group under: anatomical structure development; biological regulation; cellular component organization or biogenesis; organ development; embryonic development via the syncytial blastoderm; regulation of cellular macromolecule biosynthetic process; sensory organ development; locomotion; anterior/posterior axis specification; notum cell fate specification; tripartite regional subdivision; lymph gland development; tissue homeostasis. 21 alleles are reported. The phenotypes of these alleles are annotated with: organ system subdivision; synaptic neuropil subdomain; adult segment; antennal segment; multi-cell-component structure; cephalopharyngeal skeleton; adult mesothoracic segment; pharyngeal sclerite; appendage segment; extended germ band embryo. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Homeobox; Homeobox, conserved site; Homeodomain-like; Homeodomain-related; Zinc finger, LIM-type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 00-18 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1625279_a_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of tup. Gene sequence location is 2L:18859500..18881256.
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	tup: tailup Embryonic lethal. Head broad. Germband shortening apparently ceases early, resulting in the posteriormost three segments remaining on dorsal side of the embryo.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10	References FlyBase Curators, 2010-, Gene Ontology (GO) annotation review.
FB2012_01	Sequence features BKN21540 HFA03627
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 37B1-37B1   Limits computationally determined from genome sequence between P{EP}CG10413EP2164 and P{lacW}l(2)37Dbk16106&P{lacW}Catsupk05424
Experimentally Determined Cytological Location
Cytogenetic map Notes References 37A-37A   (determined by in situ hybridisation)   (Thor and Thomas, 1997)
Experimentally Determined Recombination Data
Location	2-53.9   2-54 (Tearle and Nusslein-Volhard, 1987) 2-54.0 (Zak, 1998)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\tup for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) tup-RA FBtr0081111  NM_057427   3238   534 tup-RB FBtr0081112  NM_057426   3316   465
Additional Transcript Data & Comments
Reported size (kB)	3.237 (longest cDNA) (Thor and Thomas, 1997)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein tup-PA   FBpp0080661   58.0   534   7.85     NP_476775   AAF53720 tup-PB   FBpp0080662   51.8   465   7.63     NP_476774   AAN11018
Additional Polypeptide Data & Comments
Reported size (kDa)	534 (aa) (Thor and Thomas, 1997)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Homeobox, conserved site (IPR017970) Homeobox (IPR001356) Zinc finger, LIM-type (IPR001781) Homeodomain-like (IPR009057) Homeodomain-related (IPR012287)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141142   AE014134 AAF53720   AE014134 AAN11018   AC009204   AF145674 AAD38649   AI134793   AI134803   AI402286   BI165239   BI165645   BI167730   BI170604   BI171148   BI216979   BI230005   BI234956   BI237433   BI239919   BI358333   BI368601   BI368627   BI482045   BI482263   BI485749   BI485776   BI579791   CO177198   CO185485   CO188302   CO188836   CO277536   CO283356   CO292662   CO300883   CO303832   CO308355   CO308487   CO310214   CO310732   CO311595   CO312377   CO315506   CO316334   CO317690   CO318217   CO323960   CO326444   CO326468   CO329538   CO344717   CZ487289   CZ487290   EC066473   EC066640   EC076020   EC077677   EC080695   EC195639   EC199524   EC202110   EC203748   EC209180   EC212209   EC214581   EC223731   EC225290   EC235604   EC236801   EC238468   EC239354   EC250067   EC255604   EC257501   EC259039   FF579108   GH944242   GH944357   GH944607   GH944677   GH944915   GH946422   GH946992   GH949651   GH951820   GH952722   GH953146   GH953486   GH956225   GH957811   GH958277   GH959423   GH962512   GH962576   GH965254   GH966219   GH968516   GH969149   GH969764   GH969985   GH970443   GH970567   GH971374   GH971913   GH972473   GH974169   GH974402   GH975834   GH976244   GH977595   GH977609   GH978275   GH980119   GH980264   GH980588   GH982867   GH985053   U89385
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	P92031 Q9VJ37 Q9Y0Z9
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 6   amnioserosa anlage   (Wharton et al., 2004) dorsal ectoderm | dorso-lateral   (Wharton et al., 2004) embryonic stage 10   amnioserosa   (Thor and Thomas, 1997) embryonic/larval pharynx | precursor   (Thor and Thomas, 1997) foregut primordium   (Thor and Thomas, 1997) embryonic stage 10 -- 16   embryonic/larval dorsal vessel   (Thor and Thomas, 1997) embryonic stage 12 -- 17   embryonic brain | restricted   (Thor and Thomas, 1997) ventral nerve cord | restricted   (Thor and Thomas, 1997) embryonic stage 16   pharyngeal muscle   (Thor and Thomas, 1997) embryonic/larval alary muscle   (Thor and Thomas, 1997)
Additional Descriptive Data
	tup transcript is first detected in stage 10 embryos in the precursors of the dorsal vessel, pharynx, and amnioserosa. By stage 16 expression has narrowed to the dorsal vessel and the alary and pharyngeal muscles. tup CNS expression is detected in stage 12 embryos in subsets of cells in the ventral nerve cord and brain. Expression is not found in neuroblasts, but in neuronal progeny. By stage 13, there are 20 cells expressing tup per hemisegment, and this pattern is retained through embryonic development. Reporter construct expression (Btau\MAPTisl.H.T:Hsap\MYC) indicates that the tup expressing cells are a subset of motor neurons and interneurons. (Thor and Thomas, 1997)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage 10   embryonic/larval pharynx | precursor   (Thor and Thomas, 1997) amnioserosa   (Thor and Thomas, 1997) embryonic stage 10 -- 16   embryonic/larval dorsal vessel   (Thor and Thomas, 1997) embryonic stage 12   ventral nerve cord | restricted   (Thor and Thomas, 1997) embryonic brain | restricted   (Thor and Thomas, 1997) embryonic stage 16   embryonic/larval alary muscle   (Thor and Thomas, 1997) pharyngeal muscle   (Thor and Thomas, 1997) pupal stage P5(ii)   antennal lobe projection neuron adPN | subset   (Komiyama and Luo, 2007) antennal lobe projection neuron lPN | subset   (Komiyama and Luo, 2007) adult stage   adult antennal lobe projection neuron DL1 adPN | subset   (Komiyama and Luo, 2007) adult antennal lobe projection neuron D adPN | subset   (Komiyama and Luo, 2007) adult antennal lobe projection neuron VA3 adPN | subset   (Komiyama and Luo, 2007) adult antennal lobe projection neuron VA1d adPN | subset   (Komiyama and Luo, 2007) adult antennal lobe projection neuron VM7 adPN | subset   (Komiyama and Luo, 2007) adult antennal lobe projection neuron VM2 adPN | subset   (Komiyama and Luo, 2007) adult antennal lobe projection neuron DM6 adPN | subset   (Komiyama and Luo, 2007) adult antennal lobe projection neuron VA1lm adPN | subset   (Komiyama and Luo, 2007) adult antennal lobe projection neuron DA1 lPN | subset   (Komiyama and Luo, 2007) adult antennal lobe projection neuron DL3 lPN | subset   (Komiyama and Luo, 2007) adult antennal lobe projection neuron VA7m lPN | subset   (Komiyama and Luo, 2007) adult antennal lobe projection neuron VA5 lPN | subset   (Komiyama and Luo, 2007) adult antennal lobe projection neuron DM5 lPN | subset   (Komiyama and Luo, 2007) adult antennal lobe projection neuron DM2 lPN | subset   (Komiyama and Luo, 2007) adult antennal lobe projection neuron DM1 lPN | subset   (Komiyama and Luo, 2007)
Additional Descriptive Data
	Approximately 50% of adPNs and 80% of lPNs express tup. (Komiyama and Luo, 2007) The pattern of tup protein expression closely matches that of tup transcript expression. CNS expression is detected in subsets of cells in the brain and ventral nerve cord starting at stage 12; the pattern of about 20 tup expressing cells per hemisegment seen by stage 13 is retained through the rest of embryogenesis. (Thor and Thomas, 1997)
Marker for
Subcellular Localization
CV Term	nucleus (Thor and Thomas, 1997)
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0003896    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0003896 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 00-18 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0003896 expression level Developmental Stage   Expression Level embryo 00-02hr    33 embryo 02-04hr    481 embryo 04-06hr    1432 embryo 06-08hr    1721 embryo 08-10hr    2017 embryo 10-12hr    2411 embryo 12-14hr    1901 embryo 14-16hr    1017 embryo 16-18hr    824 embryo 18-20hr    703 embryo 20-22hr    518 embryo 22-24hr    559 larva L1    432 larva L2    200 larva L3 12hr old    188 larva L3 puffstage 1-2    123 larva L3 puffstage 3-6    312 larva L3 puffstage 7-9    438 white prepupae new    554 white prepupae 12hr    547 white prepupae 24hr    786 pupae 2d postWPP    386 pupae 3d postWPP    177 pupae 4d postWPP    235 adult male 01day    170 adult male 05day    185 adult male 30day    152 adult female 01day    97 adult female 05day    43 adult female 30day    33 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    33 embryo 02-04hr  (481) embryo 04-06hr  (1432) embryo 06-08hr  (1721) embryo 08-10hr  (2017) embryo 10-12hr  (2411) embryo 12-14hr  (1901) embryo 14-16hr  (1017) embryo 16-18hr  (824) embryo 18-20hr  (703) embryo 20-22hr  (518) embryo 22-24hr  (559) larva L1  (432) larva L2  (200) larva L3 12hr old  (188) larva L3 puffstage 1-2  (123) larva L3 puffstage 3-6  (312) larva L3 puffstage 7-9  (438) white prepupae new  (554) white prepupae 12hr  (547) white prepupae 24hr  (786) pupae 2d postWPP  (386) pupae 3d postWPP  (177) pupae 4d postWPP  (235) adult male 01day  (170) adult male 05day  (185) adult male 30day  (152) adult female 01day    97 adult female 05day    43 adult female 30day    33 Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    33 embryo 02-04hr    481 embryo 04-06hr  1432 embryo 06-08hr  (1721) embryo 08-10hr  (2017) embryo 10-12hr  (2411) embryo 12-14hr  (1901) embryo 14-16hr    1017 embryo 16-18hr    824 embryo 18-20hr    703 embryo 20-22hr    518 embryo 22-24hr    559 larva L1    432 larva L2    200 larva L3 12hr old    188 larva L3 puffstage 1-2    123 larva L3 puffstage 3-6    312 larva L3 puffstage 7-9    438 white prepupae new    554 white prepupae 12hr    547 white prepupae 24hr    786 pupae 2d postWPP    386 pupae 3d postWPP    177 pupae 4d postWPP    235 adult male 01day    170 adult male 05day    185 adult male 30day    152 adult female 01day    97 adult female 05day    43 adult female 30day    33 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    33 embryo 02-04hr    481 embryo 04-06hr    1432 embryo 06-08hr    1721 embryo 08-10hr    2017 embryo 10-12hr    2411 embryo 12-14hr    1901 embryo 14-16hr    1017 embryo 16-18hr    824 embryo 18-20hr    703 embryo 20-22hr    518 embryo 22-24hr    559 larva L1    432 larva L2    200 larva L3 12hr old    188 larva L3 puffstage 1-2    123 larva L3 puffstage 3-6    312 larva L3 puffstage 7-9    438 white prepupae new    554 white prepupae 12hr    547 white prepupae 24hr    786 pupae 2d postWPP    386 pupae 3d postWPP    177 pupae 4d postWPP    235 adult male 01day    170 adult male 05day    185 adult male 30day    152 adult female 01day    97 adult female 05day    43 adult female 30day    33 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    33 embryo 02-04hr    481 embryo 04-06hr    1432 embryo 06-08hr    1721 embryo 08-10hr    2017 embryo 10-12hr    2411 embryo 12-14hr    1901 embryo 14-16hr    1017 embryo 16-18hr    824 embryo 18-20hr    703 embryo 20-22hr    518 embryo 22-24hr    559 larva L1    432 larva L2    200 larva L3 12hr old    188 larva L3 puffstage 1-2    123 larva L3 puffstage 3-6    312 larva L3 puffstage 7-9    438 white prepupae new    554 white prepupae 12hr    547 white prepupae 24hr    786 pupae 2d postWPP    386 pupae 3d postWPP    177 pupae 4d postWPP    235 adult male 01day    170 adult male 05day    185 adult male 30day    152 adult female 01day    97 adult female 05day    43 adult female 30day    33 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0003896 expression level Developmental Stage   Expression Level embryo 00-02hr    33 embryo 02-04hr    481 embryo 04-06hr    1432 embryo 06-08hr    1721 embryo 08-10hr    2017 embryo 10-12hr    2411 embryo 12-14hr    1901 embryo 14-16hr    1017 embryo 16-18hr    824 embryo 18-20hr    703 embryo 20-22hr    518 embryo 22-24hr    559 larva L1    432 larva L2    200 larva L3 12hr old    188 larva L3 puffstage 1-2    123 larva L3 puffstage 3-6    312 larva L3 puffstage 7-9    438 white prepupae new    554 white prepupae 12hr    547 white prepupae 24hr    786 pupae 2d postWPP    386 pupae 3d postWPP    177 pupae 4d postWPP    235 adult male 01day    170 adult male 05day    185 adult male 30day    152 adult female 01day    97 adult female 05day    43 adult female 30day    33 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    33 embryo 02-04hr  (481) embryo 04-06hr  (1432) embryo 06-08hr  (1721) embryo 08-10hr  (2017) embryo 10-12hr  (2411) embryo 12-14hr  (1901) embryo 14-16hr  (1017) embryo 16-18hr  (824) embryo 18-20hr  (703) embryo 20-22hr  (518) embryo 22-24hr  (559) larva L1  (432) larva L2  (200) larva L3 12hr old  (188) larva L3 puffstage 1-2  123 larva L3 puffstage 3-6  (312) larva L3 puffstage 7-9  (438) white prepupae new  (554) white prepupae 12hr  (547) white prepupae 24hr  (786) pupae 2d postWPP  (386) pupae 3d postWPP  (177) pupae 4d postWPP  (235) adult male 01day  (170) adult male 05day  (185) adult male 30day  (152) adult female 01day    97 adult female 05day    43 adult female 30day    33 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    33 embryo 02-04hr    481 embryo 04-06hr  1432 embryo 06-08hr  1721 embryo 08-10hr  2017 embryo 10-12hr  2411 embryo 12-14hr  1901 embryo 14-16hr    1017 embryo 16-18hr    824 embryo 18-20hr    703 embryo 20-22hr    518 embryo 22-24hr    559 larva L1    432 larva L2    200 larva L3 12hr old    188 larva L3 puffstage 1-2    123 larva L3 puffstage 3-6    312 larva L3 puffstage 7-9    438 white prepupae new    554 white prepupae 12hr    547 white prepupae 24hr    786 pupae 2d postWPP    386 pupae 3d postWPP    177 pupae 4d postWPP    235 adult male 01day    170 adult male 05day    185 adult male 30day    152 adult female 01day    97 adult female 05day    43 adult female 30day    33 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    33 embryo 02-04hr    481 embryo 04-06hr    1432 embryo 06-08hr    1721 embryo 08-10hr    2017 embryo 10-12hr    2411 embryo 12-14hr    1901 embryo 14-16hr    1017 embryo 16-18hr    824 embryo 18-20hr    703 embryo 20-22hr    518 embryo 22-24hr    559 larva L1    432 larva L2    200 larva L3 12hr old    188 larva L3 puffstage 1-2    123 larva L3 puffstage 3-6    312 larva L3 puffstage 7-9    438 white prepupae new    554 white prepupae 12hr    547 white prepupae 24hr    786 pupae 2d postWPP    386 pupae 3d postWPP    177 pupae 4d postWPP    235 adult male 01day    170 adult male 05day    185 adult male 30day    152 adult female 01day    97 adult female 05day    43 adult female 30day    33 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    33 embryo 02-04hr    481 embryo 04-06hr    1432 embryo 06-08hr    1721 embryo 08-10hr    2017 embryo 10-12hr    2411 embryo 12-14hr    1901 embryo 14-16hr    1017 embryo 16-18hr    824 embryo 18-20hr    703 embryo 20-22hr    518 embryo 22-24hr    559 larva L1    432 larva L2    200 larva L3 12hr old    188 larva L3 puffstage 1-2    123 larva L3 puffstage 3-6    312 larva L3 puffstage 7-9    438 white prepupae new    554 white prepupae 12hr    547 white prepupae 24hr    786 pupae 2d postWPP    386 pupae 3d postWPP    177 pupae 4d postWPP    235 adult male 01day    170 adult male 05day    185 adult male 30day    152 adult female 01day    97 adult female 05day    43 adult female 30day    33 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0003896    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0003896 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0003896 expression level Tissue   Expression Level Larval Central Nervous System    86 Larval Midgut    9.3 Larval Hindgut    75.6 Larval Malpighian Tubules    1.2 Larval Fat Body    1.3 Larval Salivary Gland    2 Larval Trachea    5.425 Larval Carcass    12.675 Adult Head    15.3 Adult Eye    0.975 Adult Brain    87.8 Adult Thoracic-Abdominal Ganglion    20 Adult Crop    63.6 Adult Midgut    8.1 Adult Hindgut    6.8 Adult Malpighian Tubules    1.3 Adult Fat Body    5.3 Adult Salivary Gland    6.1 Adult Heart    57.875 Adult VirginFemale Spermatheca    0.9 Adult InseminatedFemale Spermatheca    0.3 Adult Ovary    0.3 Adult Testis    2.6 Adult Male Accessory Gland    1.6 Adult Carcass    7.2 Expression Level Scale  None   Low  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    86 Larval Midgut    9.3 Larval Hindgut    75.6 Larval Malpighian Tubules    1.2 Larval Fat Body    1.3 Larval Salivary Gland    2 Larval Trachea    5.425 Larval Carcass    12.675 Adult Head    15.3 Adult Eye    0.975 Adult Brain    87.8 Adult Thoracic-Abdominal Ganglion    20 Adult Crop    63.6 Adult Midgut    8.1 Adult Hindgut    6.8 Adult Malpighian Tubules    1.3 Adult Fat Body    5.3 Adult Salivary Gland    6.1 Adult Heart    57.875 Adult VirginFemale Spermatheca    0.9 Adult InseminatedFemale Spermatheca    0.3 Adult Ovary    0.3 Adult Testis    2.6 Adult Male Accessory Gland    1.6 Adult Carcass    7.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    86 Larval Midgut    9.3 Larval Hindgut    75.6 Larval Malpighian Tubules    1.2 Larval Fat Body    1.3 Larval Salivary Gland    2 Larval Trachea    5.425 Larval Carcass    12.675 Adult Head    15.3 Adult Eye    0.975 Adult Brain    87.8 Adult Thoracic-Abdominal Ganglion    20 Adult Crop    63.6 Adult Midgut    8.1 Adult Hindgut    6.8 Adult Malpighian Tubules    1.3 Adult Fat Body    5.3 Adult Salivary Gland    6.1 Adult Heart    57.875 Adult VirginFemale Spermatheca    0.9 Adult InseminatedFemale Spermatheca    0.3 Adult Ovary    0.3 Adult Testis    2.6 Adult Male Accessory Gland    1.6 Adult Carcass    7.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    86 Larval Midgut    9.3 Larval Hindgut    75.6 Larval Malpighian Tubules    1.2 Larval Fat Body    1.3 Larval Salivary Gland    2 Larval Trachea    5.425 Larval Carcass    12.675 Adult Head    15.3 Adult Eye    0.975 Adult Brain    87.8 Adult Thoracic-Abdominal Ganglion    20 Adult Crop    63.6 Adult Midgut    8.1 Adult Hindgut    6.8 Adult Malpighian Tubules    1.3 Adult Fat Body    5.3 Adult Salivary Gland    6.1 Adult Heart    57.875 Adult VirginFemale Spermatheca    0.9 Adult InseminatedFemale Spermatheca    0.3 Adult Ovary    0.3 Adult Testis    2.6 Adult Male Accessory Gland    1.6 Adult Carcass    7.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0003896 expression level Tissue   Expression Level Larval Central Nervous System    86 Larval Midgut    9.3 Larval Hindgut    75.6 Larval Malpighian Tubules    1.2 Larval Fat Body    1.3 Larval Salivary Gland    2 Larval Trachea    5.425 Larval Carcass    12.675 Adult Head    15.3 Adult Eye    0.975 Adult Brain    87.8 Adult Thoracic-Abdominal Ganglion    20 Adult Crop    63.6 Adult Midgut    8.1 Adult Hindgut    6.8 Adult Malpighian Tubules    1.3 Adult Fat Body    5.3 Adult Salivary Gland    6.1 Adult Heart    57.875 Adult VirginFemale Spermatheca    0.9 Adult InseminatedFemale Spermatheca    0.3 Adult Ovary    0.3 Adult Testis    2.6 Adult Male Accessory Gland    1.6 Adult Carcass    7.2 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    86 Larval Midgut    9.3 Larval Hindgut    75.6 Larval Malpighian Tubules    1.2 Larval Fat Body    1.3 Larval Salivary Gland    2 Larval Trachea    5.425 Larval Carcass    12.675 Adult Head    15.3 Adult Eye    0.975 Adult Brain    87.8 Adult Thoracic-Abdominal Ganglion    20 Adult Crop    63.6 Adult Midgut    8.1 Adult Hindgut    6.8 Adult Malpighian Tubules    1.3 Adult Fat Body    5.3 Adult Salivary Gland    6.1 Adult Heart    57.875 Adult VirginFemale Spermatheca    0.9 Adult InseminatedFemale Spermatheca    0.3 Adult Ovary    0.3 Adult Testis    2.6 Adult Male Accessory Gland    1.6 Adult Carcass    7.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    86 Larval Midgut    9.3 Larval Hindgut    75.6 Larval Malpighian Tubules    1.2 Larval Fat Body    1.3 Larval Salivary Gland    2 Larval Trachea    5.425 Larval Carcass    12.675 Adult Head    15.3 Adult Eye    0.975 Adult Brain    87.8 Adult Thoracic-Abdominal Ganglion    20 Adult Crop    63.6 Adult Midgut    8.1 Adult Hindgut    6.8 Adult Malpighian Tubules    1.3 Adult Fat Body    5.3 Adult Salivary Gland    6.1 Adult Heart    57.875 Adult VirginFemale Spermatheca    0.9 Adult InseminatedFemale Spermatheca    0.3 Adult Ovary    0.3 Adult Testis    2.6 Adult Male Accessory Gland    1.6 Adult Carcass    7.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    86 Larval Midgut    9.3 Larval Hindgut    75.6 Larval Malpighian Tubules    1.2 Larval Fat Body    1.3 Larval Salivary Gland    2 Larval Trachea    5.425 Larval Carcass    12.675 Adult Head    15.3 Adult Eye    0.975 Adult Brain    87.8 Adult Thoracic-Abdominal Ganglion    20 Adult Crop    63.6 Adult Midgut    8.1 Adult Hindgut    6.8 Adult Malpighian Tubules    1.3 Adult Fat Body    5.3 Adult Salivary Gland    6.1 Adult Heart    57.875 Adult VirginFemale Spermatheca    0.9 Adult InseminatedFemale Spermatheca    0.3 Adult Ovary    0.3 Adult Testis    2.6 Adult Male Accessory Gland    1.6 Adult Carcass    7.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    15.3   NA  Eye    0.975   NA  Brain    87.8   86  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    20   NA  Crop    63.6   9.3  Midgut    8.1   75.6  Hindgut    6.8   1.2  Malpighian Tubules    1.3   1.3  Fat Body    5.3   2  Salivary Gland    6.1   NA  Heart    57.875   5.425  Trachea    NA   NA  VirginFemale Spermatheca    0.9   NA  InseminatedFemale Spermatheca    0.3   NA  Ovary    0.3   NA  Testis    2.6   NA  Male Accessory Gland    1.6   12.675  Carcass    7.2 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_11
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003896 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10619-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for tup Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | embryonic stage tup1 tup2 tupE52 tupE53 tupE55 tupisl-1 lethal | embryonic stage | partially tup2L-57-40 tupE115 lethal | embryonic stage | recessive tup1 tup2L-57-40 tupunspecified lethal | first instar larval stage tup2L-57-40 tupE115 semi-lethal | recessive tupd03613 semi-viable tupJQ3 viable tupd03613 tupE20 viable, with Scer\GAL4pnr-MD237 tupGD4728 Other Phenotypes Allele neuroanatomy defective tup1 neuroanatomy defective (with Df(2L)OD15) tupisl-1 neuroanatomy defective | dominant tupisl-1 neuroanatomy defective | embryonic stage, with Scer\GAL4sca-537.4 tupScer\UAS.cTa neuroanatomy defective | embryonic stage | recessive tupisl-1 neuroanatomy defective | somatic clone tupisl-1 visible, with Scer\GAL4ap-md544 tupΔHD.Scer\UAS visible, with Scer\GAL4C-765 tupScer\UAS.cTa visible, with Scer\GAL4MS248 tupdsRNA.Scer\UAS visible, with Scer\GAL4pnr-MD237 tupdsRNA.Scer\UAS visible | recessive tupd03613 visible | recessive | somatic clone tupex4 visible | somatic clone tup2 tupex4 tupisl-1 tupunspecified Phenotype manifest in Allele adult antennal lobe projection neuron DL1 adPN tup1 adult antennal lobe projection neuron DL1 adPN | somatic clone tupisl-1 adult antennal lobe projection neuron DM1 lPN tup1 adult antennal lobe projection neuron DM1 lPN | somatic clone tupisl-1 adult antennal lobe projection neuron DM2 lPN tup1 adult antennal lobe projection neuron DM2 lPN | somatic clone tupisl-1 adult antennal lobe projection neuron DM5 lPN tup1 adult antennal lobe projection neuron DM5 lPN | somatic clone tupisl-1 adult antennal lobe projection neuron DM6 adPN tup1 adult antennal lobe projection neuron DM6 adPN | somatic clone tupisl-1 adult antennal lobe projection neuron VA1lm adPN tup1 adult antennal lobe projection neuron VA1lm adPN | somatic clone tupisl-1 adult antennal lobe projection neuron VA3 adPN tup1 adult antennal lobe projection neuron VA3 adPN | somatic clone tupisl-1 adult antennal lobe projection neuron VA5 lPN tup1 adult antennal lobe projection neuron VA5 lPN | somatic clone tupisl-1 adult antennal lobe projection neuron VA7m lPN tup1 adult antennal lobe projection neuron VA7m lPN | somatic clone tupisl-1 adult antennal lobe projection neuron VM2 adPN tup1 adult antennal lobe projection neuron VM2 adPN | somatic clone tupisl-1 adult antennal lobe projection neuron VM7 adPN tup1 adult antennal lobe projection neuron VM7 adPN | somatic clone tupisl-1 adult cuticle | somatic clone tup2 tupisl-1 tupunspecified tupex4 amnioserosa tup1 antennal lobe glomerulus DA1 tup1 antennal lobe glomerulus DA1 | somatic clone tupisl-1 antennal lobe glomerulus DL1 tup1 antennal lobe glomerulus DL1 | somatic clone tupisl-1 antennal lobe glomerulus DM1 tup1 antennal lobe glomerulus DM1 | somatic clone tupisl-1 antennal lobe glomerulus DM2 tup1 antennal lobe glomerulus DM2 | somatic clone tupisl-1 antennal lobe glomerulus DM5 tup1 antennal lobe glomerulus DM5 | somatic clone tupisl-1 antennal lobe glomerulus DM6 tup1 antennal lobe glomerulus DM6 | somatic clone tupisl-1 antennal lobe glomerulus VA1 lateral compartment tup1 antennal lobe glomerulus VA1 lateral compartment | somatic clone tupisl-1 antennal lobe glomerulus VA1 medial compartment tup1 antennal lobe glomerulus VA1 medial compartment | somatic clone tupisl-1 antennal lobe glomerulus VA3 tup1 antennal lobe glomerulus VA3 | somatic clone tupisl-1 antennal lobe glomerulus VA5 tup1 antennal lobe glomerulus VA5 | somatic clone tupisl-1 antennal lobe glomerulus VM2 tup1 antennal lobe glomerulus VM2 | somatic clone tupisl-1 antennal lobe glomerulus VM7 tup1 antennal lobe glomerulus VM7 | somatic clone tupisl-1 bipolar dendrite neuron | embryonic stage tupisl-1 cephalopharyngeal skeleton tup1 dopaminergic neuron | embryonic stage tupisl-1 dorsal bridge tup1 dorsal closure embryo tup1 dorsocentral bristle, with Scer\GAL4MS248 tupdsRNA.Scer\UAS dorsocentral bristle, with Scer\GAL4pnr-MD237 tupΔHD.Scer\UAS tupScer\UAS.cTa dorsocentral bristle | somatic clone | supernumerary tupisl-1 dorsocentral bristle | supernumerary tupd03613 embryonic/first instar larval cuticle | dorsal tup1 tup2 tup2L-57-40 tupisl-1 tupE52 tupE53 tupE55 tupE115 embryonic head tup1 tupunspecified extended germ band embryo tup1 tupunspecified external sensory organ precursor cell | supernumerary tupd03613 femur, with Scer\GAL4dpp.blk1 tupScer\UAS.cTa interneuron | embryonic stage tupisl-1 interneuron | embryonic stage, with Scer\GAL4sca-537.4 tupScer\UAS.cTa intersegmental nerve | embryonic stage 16 tupisl-1 intersegmental nerve | embryonic stage 16 (with Df(2L)OD15) tupisl-1 intrinsic neuron | embryonic stage tupisl-1 macrochaeta | ectopic | somatic clone tup2 mesothoracic bristle | somatic clone tupex4 mesothoracic pleurum, with Scer\GAL4C-765 tupScer\UAS.cTa mesothoracic tergum | somatic clone tup2 tupunspecified metatarsus, with Scer\GAL4dpp.blk1 tupScer\UAS.cTa metathoracic laterotergite | somatic clone tupunspecified motor neuron | embryonic stage tupisl-1 motor neuron | embryonic stage, with Scer\GAL4sca-537.4 tupScer\UAS.cTa scutellar bristle, with Scer\GAL4pnr-MD237 tupΔHD.Scer\UAS tupScer\UAS.cTa scutellar bristle (with tup2) tupJQ3 scutellar bristle (with tupex4) tupJQ3 scutellar bristle (with tupJQ3) tup2 tupex4 scutellar bristle | somatic clone | supernumerary tupisl-1 tupex4 scutellar bristle | supernumerary tupd03613 scutellar bristle | supernumerary, with Scer\GAL4MS248 tupdsRNA.Scer\UAS scutellar bristle | supernumerary, with Scer\GAL4pnr-MD237 tupdsRNA.Scer\UAS scutellum | somatic clone tupisl-1 scutum | somatic clone tupisl-1 sensillum campaniformium | ectopic | somatic clone tupunspecified sensillum trichodeum | ectopic | somatic clone tup2 serotonergic neuron | embryonic stage tupisl-1 subesophageal ganglion tup1 subesophageal ganglion | somatic clone tupisl-1 tarsal segment 4, with Scer\GAL4ap-md544 tupScer\UAS.cTa tegula, with Scer\GAL4C-765 tupScer\UAS.cTa tegula | ectopic | somatic clone tup2 tupex4 thorax, with Scer\GAL4pnr-MD237 tupΔHD.Scer\UAS tupScer\UAS.cTa tibia, with Scer\GAL4dpp.blk1 tupScer\UAS.cTa transverse nerve | embryonic stage 16 tupisl-1 transverse nerve | embryonic stage 16 (with Df(2L)OD15) tupisl-1 unguis, with Scer\GAL4dpp.blk1 tupScer\UAS.cTa vertical bridge tup1 wing, with Scer\GAL4ap-md544 tupΔHD.Scer\UAS tupScer\UAS.cTa wing disc | somatic clone tupisl-1 tupex4 wing sclerite | ectopic | somatic clone tup2
Classical Alleles ( 14 )
For All Classical Alleles Show
Allele of tup Class Mutagen Stocks Known lesion tup1 amorphic allele - genetic evidence ethyl methanesulfonate 3 Yes tupisl-1 amorphic allele - genetic evidence ethyl methanesulfonate 3 Yes tupd03613 hypomorphic allele - genetic evidence P-element activity 3 Yes tupf04735 piggyBac transposase 1 -- tup2 amorphic allele - genetic evidence ethyl methanesulfonate 0 Yes tupE52 amorphic allele - genetic evidence 0 Yes tupE53 amorphic allele - genetic evidence ethyl methanesulfonate 0 Yes tupE55 amorphic allele - genetic evidence 0 Yes tup2L-57-40 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes tupE115 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes tupE20 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes tupex4 0 Yes tupJQ3 P-element activity 0 Yes tupunspecified 0 --
Alleles Carried on Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Allele of tup Class Mutagen Stocks Known lesion tupGD4728 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes tupKK101489 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes tupAct5C.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes tupdsRNA.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes tupScer\UAS.cTa in vitro construct - regulatory fusion 0 Yes tupΔHD.Scer\UAS in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes tupΔLIM.Scer\UAS in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)BSC332 (Christensen et al., 2008.4.15) Df(2L)Exel7072 (Ryder, 2004.4.26) Df(2L)Exel7073 (Ryder, 2004.4.26) Df(2L)OD15 (Broihier and Skeath, 2002, Goldman-Levi et al., 1996, Thor and Thomas, 1997) Df(2L)TW3 (Zak, 1998, Thor and Thomas, 1997) Df(2L)TW137 (Zak, 1998)
Not disrupted in	Df(2L)DS8 (Roote, 1996.9.11) Df(2L)H68 (Zak, 1998) Df(2L)pr-A14 (Roote, 1996.9.11) Df(2L)TW1 (Roote, 1996.9.11) Df(2L)TW158 (Zak, 1998)
Duplicated in	Df(2L)OD15 (Certel and Thor, 2004)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4728} NA P{KK101489} NA P{UAS-isl.T} NA P{UAS-isl.ΔHD} NA P{UAS-Isl.ΔLIM} NA P{UAS-tup.IR} NA reporter construct P{tup-lacZ.Z} No
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{XP}tupd03613 NA P+PBac{XP5.WH5}tupex4 NA miscellaneous insertions PBac{WH}tupf04735 NA insertion of enhancer trap binary system P{GawB}tupJQ3 No
Gene Ontology: Function, Process & Cellular Component ( 23 unique terms )
Terms Based on Experimental Evidence ( 21 terms )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with Chi (Biryukova and Heitzler, 2005) RNA polymerase II activating transcription factor binding inferred from physical interaction with pnr (Biryukova and Heitzler, 2005) RNA polymerase II distal enhancer sequence-specific DNA binding inferred from direct assay (Tao et al., 2007) RNA polymerase II regulatory region sequence-specific DNA binding inferred from direct assay (Biryukova and Heitzler, 2005) sequence-specific distal enhancer binding RNA polymerase II transcription factor activity inferred from direct assay (Tao et al., 2007)
Biological Process
CV term Evidence References
amnioserosa maintenance inferred from mutant phenotype (Frank and Rushlow, 1996) axon guidance inferred from mutant phenotype (Thor and Thomas, 1997) chaeta development inferred from mutant phenotype (de Navascués and Modolell, 2010) chaeta morphogenesis inferred from mutant phenotype (Biryukova and Heitzler, 2005) dendrite guidance inferred from mutant phenotype (Komiyama and Luo, 2007) dorsal closure inferred from mutant phenotype (Biryukova and Heitzler, 2005) germ-band shortening inferred from mutant phenotype (Frank and Rushlow, 1996, Goldman-Levi et al., 1996) heart development inferred from mutant phenotype (Tao et al., 2007) lymph gland development inferred from mutant phenotype (Tao et al., 2007) motor axon guidance inferred from mutant phenotype (Certel and Thor, 2004) negative regulation of sequence-specific DNA binding transcription factor activity inferred from direct assay (Biryukova and Heitzler, 2005) notum cell fate specification inferred from mutant phenotype (de Navascués and Modolell, 2007) positive regulation of transcription from RNA polymerase II promoter inferred from direct assay (Tao et al., 2007) terminal region determination inferred from genetic interaction with tor (Strecker et al., 1991) torso signaling pathway inferred from genetic interaction with tor (Strecker et al., 1991)
Cellular Component
CV term Evidence References
nucleus inferred from direct assay (Thor and Thomas, 1997, Tao et al., 2007)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
zinc ion binding inferred from electronic annotation with InterPro:IPR001781 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
head involution non-traceable author statement (Frank and Rushlow, 1996)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions tup allele Gene References tup1 tor (Li and Li, 2003) ush (Goldman-Levi et al., 1996) tupisl-1 vvl (Certel and Thor, 2004) tupScer\UAS.cTa B (Pueyo and Couso, 2004) tupunspecified exex (Broihier and Skeath, 2002) vvl (Certel and Thor, 2004) unspecified ap (Biryukova and Heitzler, 2005, O'Keefe et al., 1998) Chi (Biryukova and Heitzler, 2005) pnr (Biryukova and Heitzler, 2005) SoxN (Girard et al., 2006)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 61139 DroID - A comprehensive database of gene and protein interactions. • FBgn0003896 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35147
Orthologs
Genome-wide drosophilid orthologs	Dana\GF14867 Dere\GG21675 Dgri\GH11521 Dmoj\GI17017 Dper\GL18825 Dpse\GA10441 Dsec\GM17053 Dsim\GD21801 Dvir\GJ24442 Dwil\GK23894 Dyak\GE12696
Curated drosophilid orthologs	Dpse\GA10441
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL001500-PA Aedes aegypti (mosquito) AGAP010209-PA Anopheles gambiae (mosquito) XP_001944557.1 Acyrthosiphon pisum (pea aphid) 116887 Branchiostoma floridae (lancelet) BGIBMGA013872-PA Bombyx mori (silk worm) ENSBTAP00000001638 Bos taurus (bovine) CBP06623 Caenorhabditis briggsae (nematode) CE17366 Caenorhabditis elegans (worm) ENSCAFP00000027248 Canis familiaris (dog) ENSCINP00000000768 Ciona intestinalis (sea squirt) JA03176 Caenorhabditis japonica (nematode) cn10324 Cryptococcus neoformans (yeast-like fungus) CPIJ012632 Culex pipens (mosquito) ENSCPOP00000005215 Cavia porcellus (guinea pig) RP28902 Caenorhabditis remanei (nematode) ENSCSAVP00000014254 Ciona savignyi (sedentary tunicate) 219057 Capitella spl (polychaete worm) 50562 Daphnia pulex (daphnia) ENSDARP00000012903 Danio rerio (zebra fish) ENSECAP00000002355 Equus caballus (horse) ENSGACP00000005080 Gymnopilus aculeatus (mushroom) ENSGALP00000038117 Gallus gallus (chicken) 64295 Hypsipyla robusta (cedar shoot borer) ENSP00000230658 Homo sapiens (human) 232365 Lottia gigantea (owl limpet) ENSMODP00000024250 Monodelphis domestica (gray opossum) ENSMMUP00000027082 Macaca mulatta (rhesus monkey) ENSMUSP00000044879 Mus musculus (house mouse) 161808 Nematostella vectensis (starlet anemone) XP_001603153.1 Nasonia vitripennis (wasp) ENSOANP00000017075 Ornithorynchus anatinus (platypus) ENSORLP00000009843 Oryzias latipes (japanese killifish) PHUM003401-PA Pediculus humanus (human body louse) ENSPPYP00000017263 Pongo pygmaeus (orangutan) ENSPTRP00000028882 Pan troglodytes (chimpanzee) ENSRNOP00000017305 Rattus norvegicus (norway rat) Smp_138170 Schistosoma mansoni (trematode parasite) XP_001187996.1 Strongylocentrotus purpuratus (purple sea urchin) XP_001815525.1 Tribolium castaneum (red flour beetle) ENSTNIP00000014302 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000013758 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000033504 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB15514 PB15516 NV18000 LH15889 ISCW021829 ISCW021826 FBgn0230421 FBgn0225856 FBgn0211522 FBgn0193221 FBgn0171965 JGI_V11_50562 FBgn0070498 FBgn0156426 FBgn0139762 FBgn0131062 FBgn0119001 FBgn0113853 FBgn0091894 CPIJ012632 BGIBMGA013872 ACYPI002171 GB12465 AGAP010209 AAEL001500 PHUM202210 GLEAN_09339
Stocks & Reagents
Stocks Listed in FlyBase ( 12 )
Bloomington	19195 w1118; P{XP}tupd03613/CyO 36502 w*; tupisl-1 P{neoFRT}40A/CyO 36503 y1 w*; tup1 P{neoFRT}40A/CyO 2207 tup1 cn1 bw1 sp1/CyO 3556 tupisl-1 rdo1 hk1 pr1/CyO
Harvard	- P{XP}tupd03613 - PBac{WH}tupf04735
Kyoto	106739 tup1 cn1 bw1 sp1/CyO 107094 tupisl-1 rdo1 hk1 pr1/CyO 114664 yd2 w1118 P{ey-FLP.N}2; P{XP}tupd03613 P{neoFRT}40A/CyO y+
VDRC	v103585 P{KK101489}VIE-260B v45859 w1118; P{GD4728}v45859
Genomic Clones ( 3 )
	BACR03E19 BACR07J05 BACR17A06 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 107 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH12341
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH12353 RE05085 RE05577 RE08180 RE12120 RE12836 RE24484 RE27921 RE30735 RE33660 RE36541 RE45074 RE54601 RE54623 RE64688 RE64932 RE69089 RE69121 RE73873
Other clones	7370 43670 65276 66908 72139 98139 99708 102317 125039 153870 154212 160760 160776 163878 166061 190932 214213.26 214479.25 214505.19 Arica_10_H02 CK01.67A.D8 CK01255 EK009728 EK039127 EK042146 EK052748 EK125425 EK162930 EK179605 EK192041 EK200715 EK220763 EK222359 EK225522 EK228608 EK242913 EK257712 EK258445 EK261709 EK264547 EK268813 EK271013 EK293052 EP03931 EP03956 EP19758 RP004038172 RP004050588 RP004083120 RP004129310 RP004134138 RP004140743 RP004153311 RP004180413 RP004214559 RP004217223 RP004220412 RP004236960 RP004238959 RP004239152 RP004239972 RP004241770 RP004242764 RP004243122 RP004243375 RP004254004 RP004261699 RP004285726 RP004286183 RP004324033 RP004335046 RP004364680 RP004368814 RP004396334 RP004405538 RP004413591 RP004425105 RP004426877 RP004432796 RP004436981 RP004445252 RP004452975 RP004482171 RP004494095 RP004523052 RP004524366 RP004558879
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0003896 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35147
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	tup is required for the specification of the notum territory. (de Navascués and Modolell, 2007) eve and tup constitute a bimodal switch regulating axonal growth and directing motor axons to ventral (tup) or dorsal (eve) regions of the muscle field during embryogenesis. (Landgraf et al., 1999) Isolated from an embryonic expression library, using monoclonal antibodies to rat Islet-1 and Islet-2. (Thor and Thomas, 1997) tup has been cloned and characterised. (Thor and Thomas, 1997) A member of the ush-group of genes which are required for maintenance of the amnioserosa once it has differentiated. (Frank and Rushlow, 1996) Mutants affect amnioserosa differentiation as well as germ band retraction. (Frank and Rushlow, 1995) Mutations in zygotic gene tup do not interact with RpII140wimp. (Parkhurst and Ish-Horowicz, 1991) Zygotically active locus involved in the terminal developmental program in the embryo. (Strecker et al., 1991)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057426 NM_057427 RefSeq (Proteins) • NP_476774 NP_476775 DDBJ / EMBL / GenBank • AAB49892 AAD38649 AAF53720 AAN11018 AC009204 AF145674 AI134793 AI402286 CZ487289 CZ487290 U89385 Entrez Gene - A searchable database of RefSeq genes. • 35147 UniProtKB/TrEMBL • P92031 Q9VJ37 Q9Y0Z9
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Homeobox, conserved site (IPR017970) Homeobox (IPR001356) Zinc finger, LIM-type (IPR001781) Homeodomain-like (IPR009057) Homeodomain-related (IPR012287)
Linkouts
	BioGRID - A database of protein and genetic interactions • 61139 DroID - A comprehensive database of gene and protein interactions. • FBgn0003896 DRSC - Results from RNAi screens. • FBgn0003896 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003896 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10619-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0003896 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35147 InParanoid A subset of ortholog calls from InParanoid. • AAEL001500-PA Aedes aegypti (mosquito) AGAP010209-PA Anopheles gambiae (mosquito) XP_001944557.1 Acyrthosiphon pisum (pea aphid) 116887 Branchiostoma floridae (lancelet) BGIBMGA013872-PA Bombyx mori (silk worm) ENSBTAP00000001638 Bos taurus (bovine) CBP06623 Caenorhabditis briggsae (nematode) CE17366 Caenorhabditis elegans (worm) ENSCAFP00000027248 Canis familiaris (dog) ENSCINP00000000768 Ciona intestinalis (sea squirt) JA03176 Caenorhabditis japonica (nematode) cn10324 Cryptococcus neoformans (yeast-like fungus) CPIJ012632 Culex pipens (mosquito) ENSCPOP00000005215 Cavia porcellus (guinea pig) RP28902 Caenorhabditis remanei (nematode) ENSCSAVP00000014254 Ciona savignyi (sedentary tunicate) 219057 Capitella spl (polychaete worm) 50562 Daphnia pulex (daphnia) ENSDARP00000012903 Danio rerio (zebra fish) ENSECAP00000002355 Equus caballus (horse) ENSGACP00000005080 Gymnopilus aculeatus (mushroom) ENSGALP00000038117 Gallus gallus (chicken) 64295 Hypsipyla robusta (cedar shoot borer) ENSP00000230658 Homo sapiens (human) 232365 Lottia gigantea (owl limpet) ENSMODP00000024250 Monodelphis domestica (gray opossum) ENSMMUP00000027082 Macaca mulatta (rhesus monkey) ENSMUSP00000044879 Mus musculus (house mouse) 161808 Nematostella vectensis (starlet anemone) XP_001603153.1 Nasonia vitripennis (wasp) ENSOANP00000017075 Ornithorynchus anatinus (platypus) ENSORLP00000009843 Oryzias latipes (japanese killifish) PHUM003401-PA Pediculus humanus (human body louse) ENSPPYP00000017263 Pongo pygmaeus (orangutan) ENSPTRP00000028882 Pan troglodytes (chimpanzee) ENSRNOP00000017305 Rattus norvegicus (norway rat) Smp_138170 Schistosoma mansoni (trematode parasite) XP_001187996.1 Strongylocentrotus purpuratus (purple sea urchin) XP_001815525.1 Tribolium castaneum (red flour beetle) ENSTNIP00000014302 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000013758 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000033504 Xenopus tropicalis (frog) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /neural/islet1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35147 modMine - Data generated by the modENCODE project. • FBgn0003896 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB15514 PB15516 NV18000 LH15889 ISCW021829 ISCW021826 FBgn0230421 FBgn0225856 FBgn0211522 FBgn0193221 FBgn0171965 JGI_V11_50562 FBgn0070498 FBgn0156426 FBgn0139762 FBgn0131062 FBgn0119001 FBgn0113853 FBgn0091894 CPIJ012632 BGIBMGA013872 ACYPI002171 GB12465 AGAP010209 AAEL001500 PHUM202210 GLEAN_09339 REDfly - A database of transcriptional regulatory elements. • FBgn0003896
Synonyms & Secondary IDs ( 14 )
Reported As
Symbol Synonym	CG10619 (Klebes et al., 2005, Keleman et al., 2009.8.5) isl (Certel and Thor, 2004, Pueyo and Couso, 2004, Thor and Thomas, 2002, Broihier and Skeath, 2002, van Meyel et al., 2000, Anonymous, 1999, Lilly et al., 1999, Goridis and Brunet, 1999, Eisen, 1998, van Meyel et al., 1999, Toyama, 1999, Landgraf et al., 1999, Thor and Thomas, 1997, Thor et al., 1996, Thor et al., 1995, Biryukova and Heitzler, 2005, Komiyama and Luo, 2007) Isl (Certel et al., 2001, Karcavich and Doe, 2005, Tran and Doe, 2008) islet (Broihier et al., 2004, Pym et al., 2006) l(2)37Aa   l(2)E41   tup (Lin et al., 2006, Navascues and Modolell, 2007, Roignant et al., 2010, Mann et al., 2007, Zeitlinger et al., 2007, Stathopoulos and Levine, 2005, de Navascués and Modolell, 2007, Tao et al., 2007, Christensen et al., 2008.4.15, Tao et al., 2007, Miles et al., 2008, Mann et al., 2009, Stagg et al., 2011, Boettiger and Levine, 2009, Zeitlinger et al., 2007, Zúñiga et al., 2009, Engström et al., 2007, Roshina and Pasyukova, 2007, de Navascués and Modolell, 2010) Tup (Wheeler et al., 2008)
Name Synonym	dIslet (Hari et al., 2008) islet (Layden et al., 2004, Skeath and Thor, 2003, Allan et al., 2001, St. Pierre et al., 2001, Certel et al., 2001, Page, 2000, Jurata et al., 2000, Brisson et al., 2000, Hobert and Westphal, 2000, Thor, 1997.2.12, Torigoi et al., 1999, Thor et al., 1999, Pueyo and Couso, 2004, Thor and Thomas, 1997, Yeh et al., 2006, Guardiola and Crews, 2007, Navascues and Modolell, 2007, Hari et al., 2008, Komiyama and Luo, 2007, de Navascués and Modolell, 2010) Islet (Odden and Doe, 2001, Pueyo et al., 2000, Bonkowsky et al., 1999, Odden et al., 2002, Certel et al., 2001, Roignant et al., 2007, Biryukova and Heitzler, 2005, Layden et al., 2006, Asmar et al., 2007, Cheesman et al., 2004, Karcavich and Doe, 2005, Miller et al., 2008, Tran and Doe, 2008) Islet 1 (Soustelle et al., 2002) lethal(2)37Aa   tailup (Tao et al., 2007, Navascues and Modolell, 2007, Roignant et al., 2010, Mann et al., 2007, de Navascués and Modolell, 2007, Tao et al., 2007, Tao et al., 2007, Wang et al., 2008, Mann et al., 2009, Engström et al., 2007, de Navascués and Modolell, 2010) tailup/islet (Girard et al., 2006)
Secondary FlyBase IDs
	FBgn0002017 FBgn0015395
References ( 130 )
Generate a list of	All references relating to this gene ( 130 )
List References by type	Research paper  ( 72 ) Supplementary material  ( 4 ) Review  ( 14 ) Personal communication to FlyBase  ( 7 ) Abstract  ( 21 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 2 ) Stock list  ( 1 ) Computer file  ( 3 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 ) Book  ( 1 )
Recent research papers ( 4 )
	Gabilondo et al., 2011, Mech. Dev. 128(3-4): 208--221 A targeted genetic screen identifies crucial players in the specification of the Drosophila abdominal Capaergic neurons. [FBrf0213290] Stagg et al., 2011, Development 138(11): 2171--2183 Dual role for Drosophila lethal of scute in CNS midline precursor formation and dopaminergic neuron and motoneuron cell fate. [FBrf0213671] de Navascués and Modolell, 2010, Mech. Dev. 127(9-12): 393--406 The pronotum LIM-HD gene tailup is both a positive and a negative regulator of the proneural genes achaete and scute of Drosophila. [FBrf0212072] Roignant et al., 2010, Development 137(2): 273--281 The transcriptional co-factor Chip acts with LIM-homeodomain proteins to set the boundary of the eye field in Drosophila. [FBrf0209594] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...