FB2021_01, released Feb 18, 2021

Gene: Dmel\tyr1

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General Information
Symbol
Dmel\tyr1
Species
D. melanogaster
Name
tyrosine 1
Annotation Symbol
Feature Type
gene
FlyBase ID
FBgn0003910
Gene Model Status
Unannotated
Stock Availability
None publicly available
Other Summaries
Also Known As

tyr-1, tyrosinase-1

Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (0 terms)
Molecular Function (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
    -
    Summaries
    Phenotypic Description (Red Book; Lindsley and Zimm 1992)
    tyr1: tyrosine 1 (J.C. Hall)
    tyr1 originally thought to be a structural gene for phenol oxidase (Lewis and Lewis, 1963); the mutant reported to be heat stable relative to wild type, but this differential heat stability in the original mutant strain has not been confirmed (Wright, 1987b). Rizki et al. suggest that tyr1 acts as a regulator of phenol oxidase activity. Mutant homozygotes have about 10% of the phenol oxidase activity of most wildtype strains. 50 h mutant pupae lack activity for the proenzyme PHOX and have detectable but reduced amounts of the diphenol oxidase components A1, A2, and A3 as compared to Samarkand wild-type pupae (Wright, 1987b; Warner, Grell, and Jacobson, 1974, Biochem. Genet. 11: 359-65); result confirmed by Pentz, Black, and Wright, 1987, who also showed that activator preparations from tyr1 were as efficient as those from wild type (Wright, 1987b). Homozygous tyr1 adults slightly underpigmented; less so than qs which has more phenol oxidase activity. Males (normal or tyr1) have three times higher dopamine levels than females (normal or mutant); the mutants (males or females) have 70% normal dopamine levels [Burnell and Daly, 1982, Advances in Genetics, Development, and Evolution of Drosophila (Lakovaara, ed.). Plenum Press, New York, pp. 361-70)]. Homozygous viable and fertile. Hemolymph of tyr1 mutant larvae will turn black but hemolymph from mutant adults will not.
    Gene Model and Products
    Number of Transcripts
    0
    Number of Unique Polypeptides
    0
    Protein Domains (via Pfam)
    Isoform displayed:
    Pfam protein domains
    InterPro name
    classification
    start
    end
    Protein Domains (via SMART)
    Isoform displayed:
    SMART protein domains
    InterPro name
    classification
    start
    end
    Comments on Gene Model
    Sequence Ontology: Class of Gene
    gene
    Transcript Data
    Annotated Transcripts
    Additional Transcript Data and Comments
    Reported size (kB)
    Comments
    External Data
    Crossreferences
    Polypeptide Data
    Annotated Polypeptides
    Polypeptides with Identical Sequences

     

    Additional Polypeptide Data and Comments
    Reported size (kDa)
    Comments
    External Data
    Crossreferences
    Linkouts
    Sequences Consistent with the Gene Model
    Nucleotide / Polypeptide Records
      Mapped Features

      Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\tyr1 using the Feature Mapper tool.

      External Data
      Crossreferences
      Linkouts
      Expression Data
      Expression Summary Ribbons
      Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
      For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
      Transcript Expression
      Additional Descriptive Data
      Marker for
       
      Subcellular Localization
      CV Term
      Polypeptide Expression
      Additional Descriptive Data
      Marker for
       
      Subcellular Localization
      CV Term
      Evidence
      References
      Expression Deduced from Reporters
      High-Throughput Expression Data
      Associated Tools

      GBrowse - Visual display of RNA-Seq signals

      View Dmel\tyr1 in GBrowse 2
      RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
      Bulk Downloads
      RNA-Seq RPKM values for all genes
      Reference
      See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
      Developmental Proteome: Life Cycle
      Developmental Proteome: Embryogenesis
      External Data and Images
      Alleles, Insertions, Transgenic Constructs, and Aberrations
      Classical and Insertion Alleles ( 1 )
      For All Classical and Insertion Alleles Show
       
      Other relevant insertions
      Transgenic Constructs ( 0 )
      For All Alleles Carried on Transgenic Constructs Show
      Transgenic constructs containing/affecting coding region of tyr1
      Transgenic constructs containing regulatory region of tyr1
      Aberrations (Deficiencies and Duplications) ( 8 )
      Phenotypes
      For more details about a specific phenotype click on the relevant allele symbol.
      Lethality
      Allele
      viable
      Sterility
      Allele
      fertile
      Other Phenotypes
      Allele
      abnormal body color
      visible | recessive
      Phenotype manifest in
      Allele
      adult
      macrochaeta
      Orthologs
      Downloads
      Download All DIOPT Orthologs
      Download All OrthoDB Orthologs
      Human Orthologs (via DIOPT v8.0)
      Homo sapiens (Human) (0)
      No records found.
      Model Organism Orthologs (via DIOPT v8.0)
      Mus musculus (laboratory mouse) (0)
      No records found.
      Rattus norvegicus (Norway rat) (0)
      No records found.
      Xenopus tropicalis (Western clawed frog) (0)
      No records found.
      Danio rerio (Zebrafish) (0)
      No records found.
      Caenorhabditis elegans (Nematode, roundworm) (0)
      No records found.
      Arabidopsis thaliana (thale-cress) (0)
      No records found.
      Saccharomyces cerevisiae (Brewer's yeast) (0)
      No records found.
      Schizosaccharomyces pombe (Fission yeast) (0)
      No records found.
      Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( None identified )
      No orthologies identified
      Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( None identified )
      No non-Drosophilid orthologies identified
      Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( None identified )
      No non-Dipteran orthologies identified
      Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( None identified )
      No non-Insect Arthropod orthologies identified
      Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
      No non-Arthropod Metazoa orthologies identified
      Paralogs
      Downloads
      Download All DIOPT Paralogs
      Paralogs (via DIOPT v8.0)
      Drosophila melanogaster (Fruit fly) (0)
      No records found.
      Human Disease Associations
      FlyBase Human Disease Model Reports
        Disease Model Summary Ribbon
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Allele
        Disease
        Evidence
        References
        Potential Models Based on Orthology ( 0 )
        Human Ortholog
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Allele
        Disease
        Interaction
        References
        Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
        Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
        Homo sapiens (Human)
        Gene name
        Score
        OMIM
        OMIM Phenotype
        DO term
        Complementation?
        Transgene?
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        esyN Network Diagram
        Interactions Browser
        Summary of Genetic Interactions
        esyN Network Diagram
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        External Data
        Linkouts
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        External Data
        Linkouts
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        Recombination map

        2-54.5

        Cytogenetic map
        38A6-38C1
        Sequence location
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        38A6-38C1
        Left limit from non-inclusion within Df(2L)Sd37 (FBrf0051216) Right limit from inclusion within Df(2L)TW150 (FBrf0051216)
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        Experimentally Determined Recombination Data
        Location

        2-54.5

        (Huntley, 1978)
        Left of (cM)
        Right of (cM)
        Notes

        Not separated from pr.

        (Huntley, 1978)
        Stocks and Reagents
        Stocks (0)
        Genomic Clones (0)
         
          cDNA Clones (0)
           

          Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

          cDNA clones, fully sequenced
          BDGP DGC clones
            Other clones
              Drosophila Genomics Resource Center cDNA clones

              For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                cDNA Clones, End Sequenced (ESTs)
                BDGP DGC clones
                  Other clones
                    RNAi and Array Information
                    Linkouts
                    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                    Antibody Information
                    Laboratory Generated Antibodies
                     
                    Commercially Available Antibodies
                     
                    Other Information
                    Relationship to Other Genes
                    Source for database identify of
                    Source for database merge of
                    Additional comments

                    The tyr11 mutation has a point mutation in a trypsin protease that maps to the genetic interval (38A-38C) where the tyr1 complementation group maps.

                    (Sugumaran and Chase, 2004)

                    Dox-3 does not correspond to tyr1.

                    (Rizki et al., 1985)
                    Other Comments

                    Although originally considered to be the structural gene for phenol oxidase (FBrf0015054), FBrf0043263 suggest that it may be a regulator of phenol oxidase activity.

                    Origin and Etymology
                    Discoverer

                    H.W. and H.S. Lewis.

                    Etymology
                    Identification
                    External Crossreferences and Linkouts ( 1 )
                    Other crossreferences
                    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                    Synonyms and Secondary IDs (6)
                    Reported As
                    Symbol Synonym
                    tyr-1
                    (Sugumaran and Chase, 2004, Pentz et al., 1990, Wright, 1987, Rizki et al., 1985, Batterham and MacKechnie, 1980)
                    tyr1
                    (Anaka et al., 2008, Jordan et al., 2006)
                    Name Synonyms
                    Tyrosinase
                    (Zhou et al., 2003)
                    tyrosinase
                    (Nappi et al., 1991)
                    tyrosinase-1
                    (Wright, 1987)
                    tyrosine 1
                    Secondary FlyBase IDs
                      Datasets (0)
                      Study focus (0)
                      Experimental Role
                      Project
                      Project Type
                      Title
                      References (18)