A Database of Drosophila Genes & Genomes

FB2008_07, released August 8, 2008
 

Gene Dmel\Tyr2

General Information
SymbolDmel\Tyr2SpeciesD. melanogaster
NameTyrosine 2Annotation symbol
Feature typegeneFlyBase IDFBgn0003911
Created / Updated2006-08-22/2006-08-22
Genomic Location
Chromosome (arm)Recombination map2-66.3
Cytogenetic mapSequence location
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Automatically generated summary

See sections below for more information
The gene Tyrosine 2 is referred to in FlyBase by the symbol Tyr2 (FBgn0003911). It has not been localized to the genome sequence. Its molecular function is unknown. The biological processes in which it is involved are not known. 2 alleles are reported. No phenotypic data is available. It has no annotated transcripts.

hide Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage
Tyr2: Tyrosine 2 (J.C. Hall)
Tyr2/+ heterozygotes show about 50% of the diphenol oxidase activity of wild-type strains; modifiers involved in this dominant effect. Tyr2P208, isolated as a recessive light-on/light-off transient-minus mutant by Pak, also affects electroretinograms when in heteroallelic combination with the original Tyr2 (Homyk and Pye, 1988). Tyr2 homozygotes also show this ERG defect.
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FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
Experimentally Determined Recombination Data
Location
2-66.3
(Homyk and Pye, 1989)
Left of (cM)
(Homyk and Pye, 1989)
Right of (cM)
(Homyk and Pye, 1989)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology)
References
Gene Order (overall orientation not stated)
References
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Comments on Gene Model
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Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Associated CDS (aa)
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
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Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kD)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
Additional Polypeptide Data & Comments
Reported size (kD)
Comments
External Data
Linkouts
Crossreferences
hide Sequences Consistent with the Gene Model
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Maps to
      Does NOT map to
      Identified with
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      Type
      Symbol & Location
      Additional Notes
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      FlyBase-Curated Data
      Transcript and
      Protein data       		Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
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      Stage
      Tissue/Position
      Reference
      Marker for
        Subcellular Localization
        CV Term
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        Stage
        Tissue/Position
        Reference
        Marker for
          Subcellular Localization
          CV Term
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          FLIGHT - Cell culture data for RNAi and other high-throughput technologies
          •
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          Phenotype manifest in
          Allele
          hide Classical Alleles ( 2 )
          For All Classical Alleles Show

          Allele of Tyr2ClassMutagenStocksKnown lesion
          Tyr211 --
          Tyr2P208
            		0 --
            hide Alleles Carried on Transgenic Constructs ( 0 )
            For All Alleles Carried on Transgenic Constructs Show

            Allele of Tyr2ClassMutagenStocksKnown lesion
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            Transgenic Constructs
            Type of construct
            Name
            Expression data
            Insertions
            Type of insertions
            Name
            Expression data
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            Please look at the allele reports for the complete phenotype data
            Mutations of Tyr2 cause abnormalities in the electroretinogram (ERG) and/or prolonged depolarization after potential (PDA).
            (Homyk and Pye, 1989)
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            CV term
            Evidence
            References
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            CV term
            Evidence
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            CV term
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            gene
             
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            Interacts with
            Please look at the allele data for full details of the genetic interactions
            Tyr2 allele
            Gene
            References
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            Genome-wide drosophilid orthologs
            Curated drosophilid orthologs
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            Produces phenotype in
            Produces NO phenotype in
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            hide Stocks Listed in FlyBase ( 1 )
            Bloomington
            4192
            b1 cn1 Tyr21
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            cDNA Clones, Fully Sequenced
            BDGP DGC clones
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            BDGP DGC clones
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            Affy Oligo
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            hide Discoverer
            H.W. and H.S. Lewis.
             
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            Source for database identity of
            Source for database merge of
            Additional comments
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            Sequence Crossreferences
            Other Crossreferences
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            FLIGHT - Cell culture data for RNAi and other high-throughput technologies
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            hide Synonyms & Secondary IDs ( 7 )
            Reported As
            Symbol Synonym
            Tyr-2
             
            Tyr2
             
            β
             
            Name Synonym
            tyrosinase
            (Nappi et al., 1991)
            Tyrosinase
            (Zhou et al., 2003)
            Tyrosinase-2
             
            Tyrosine 2
             
            Secondary FlyBase IDs
              hide References ( 7 )
              Research paper
              Zhou et al., 2003, J. Biol. Chem. 278(48): 48210--48218
              A copper-regulated transporter required for copper acquisition, pigmentation, and specific stages of development in Drosophila melanogaster. [FBrf0167752]
              Hall, 1992, Lindsley, Zimm, 1992: 736--737
              Entry for Tyr2 [FBrf0056749]
              Nappi et al., 1991, Arch. Insect Biochem. Physiol. 18(3): 159--168
              Parasite-induced enhancement of hemolymph tyrosinase activity in a selected immune reactive strain of Drosophila melanogaster. [FBrf0053179]
              Homyk and Pye, 1989, J. Neurogenet. 5: 37--48
              Some mutations affecting neural or muscular tissues alter the physiological components of the electroretinogram in Drosophila. [FBrf0050364]
              Lewis and Lewis, 1963, Ann. N. Y. Acad. Sci. 100: 827--839
              Genetic regulation of dopa oxidase activity in Drosophila. [FBrf0015054]
              Abstract
              Lewis, 1962, Biol. Bull., Wood's Hole 123(2): 464
              Structural and control genes regulating dopa oxidase activity in Drosophila. [FBrf0014391]
              Book
              Lindsley and Zimm, 1992, The Genome of Drosophila melanogaster.
              The Genome of Drosophila melanogaster. [FBrf0066905]