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Gene Dmel\RpL40

General Information
Symbol	Dmel\RpL40	Species	D. melanogaster
Name	Ribosomal protein L40	Annotation symbol	CG2960
Feature type	protein_coding_gene	FlyBase ID	FBgn0003941
Gene Model Status	Current	Stock availability	3 publicly available
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	24E1-24E1	Sequence location	2L:4,227,642..4,228,563 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Ribosomal protein L40 is referred to in FlyBase by the symbol Dmel\RpL40 (CG2960, FBgn0003941). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: structural constituent of ribosome. Based on sequence similarity, it is predicted to be involved in the biological process: ubiquitin-dependent protein catabolic process; translation; protein modification process. 3 alleles are reported. The phenotype of these alleles is annotated with: mesothoracic tergum. It has one annotated transcript and one annotated polypeptide. Protein features are: Ribosomal protein L40e; Ubiquitin; Ubiquitin conserved site; Ubiquitin subgroup; Ubiquitin supergroup. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely high expression to a trough of very high expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, at stages throughout the pupal period, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: High levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1633277_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of RpL40. Gene sequence location is 2L:4227642..4228563.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	References Casad et al., 2011, Genetics 189(3): 861--870 Sequence features BKN27503 HFA00782
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 24E1-24E1   Limits computationally determined from genome sequence between P{lacW}edk01102 and P{PZ}tutl01085
Experimentally Determined Cytological Location
Cytogenetic map Notes References 97A-97A   (determined by in situ hybridisation)   (Ranz et al., 1997) 97A-97A   (determined by in situ hybridisation)   (Izquierdo, 1994)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\RpL40 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	<new comment>5' end taken from ARGS as reported in FBrf0055432
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) RpL40-RA FBtr0077470  NM_057428   660   128
Additional Transcript Data & Comments
Reported size (kB)	0.9 (northern blot) (Cabrera et al., 1992)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein RpL40-PA   FBpp0077159   14.7   128   10.51     NP_476776   AAF51034
Additional Polypeptide Data & Comments
Reported size (kDa)	128 (aa) (Cabrera et al., 1990, Cabrera et al., 1992)
Comments	The coding sequence for the 52aa ribosomal protein is fused to a ubiquitin coding sequence in the Drosophila genome. The 52aa ribosomal protein was shown to be released from the fusion protein by proteolytic processing and was detected by antibodies prepared against the ribosomal portion of the protein. The apparent proteolytic processing was confirmed by amino-terminal sequence analysis. The 52aa protein is associated with the large ribosomal subunit. (Redman, 1994)
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Ubiquitin (IPR000626) Ribosomal protein L40e (IPR001975) Ubiquitin conserved site (IPR019954) Ubiquitin supergroup (IPR019955) Ubiquitin subgroup (IPR019956)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA736173   AA949086   AE014134 AAF51034   AC004380   AC092217   AI062080   AI062690   AI106718   AI107380   AI107979   AI107999   AI108824   AI113457   AI134201   AI296405   AI389376   AI389695   AI405733   AI406238   AI516848   AI532372   AK340297   AY075451 AAL68264   AY231778   AY232172   AY433571   AY440451   AY826155   BE977859   BG637011   BG637539   BG640119   BI169239   BI169393   BI213333   BI232844   BI240656   BI241656   BI351727   BI352558   BI353605   BI354990   BI355322   BI355508   BI370909   BI375999   BI568657   BI584434   BI593058   BI608921   BI633419   BI641565   BP540618   BP540705   BP540706   BP541160   BP541161   BP541252   BP541253   BP541364   BP541366   BP541583   BP541713   BP541782   BP541880   BP541945   BP541982   BP542253   BP542295   BP542324   BP542666   BP542807   BP542808   BP542937   BP542938   BP543025   BP543026   BP543034   BP543035   BP543151   BP543152   BP543641   BP543771   BP543772   BP543829   BP543830   BP544027   BP544028   BP544448   BP544449   BP544582   BP544583   BP544638   BP544639   BP544652   BP544653   BP544658   BP544659   BP544904   BP544905   BP545192   BP545193   BP545368   BP545369   BP545512   BP545513   BP545589   BP545590   BP545886   BP546021   BP546135   BP546278   BP546297   BP546327   BP546330   BP546568   BP546604   BP546710   BP546757   BP546768   BP546770   BP546797   BP546836   BP546967   BP546996   BP547142   BP547180   BP547210   BP547211   BP547379   BP547414   BP547499   BP547504   BP547571   BP547599   BP547607   BP547695   BP547744   BP547960   BP548017   BP548023   BP548128   BP548222   BP548231   BP548241   BP548355   BP548540   BP548545   BP548691   BP548692   BP549087   BP549088   BP549429   BP549430   BP549566   BP549567   BP549636   BP549637   BP550025   BP550030   BP550175   BP550176   BP550199   BP550200   BP550381   BP550382   BP550539   BP550540   BP550555   BP550556   BP550653   BP550654   BP550688   BP550689   BP550874   BP550875   BP551116   BP551117   BP551574   BP551575   BP551597   BP551598   BP551599   BP551600   BP551729   BP551730   BP551822   BP551860   BP552025   BP552026   BP552033   BP552034   BP552125   BP552126   BP552357   BP552431   BP552432   BP552644   BP554075   BP554076   BP554642   BP554643   BP555159   BP555310   BP555311   BP555376   BP555377   BP555439   BP555440   BP555447   BP555506   BP555507   BP555800   BP556307   BP556308   BP556667   BP556875   BP556876   BP557429   BP557738   BP557739   BP558748   BP558749   BP559053   BP559115   BP559116   BP559324   BP559325   BP559458   BP559459   BP559494   BP559495   BP559591   BP559592   BP559602   BP559603   BP559754   BP559755   BP559834   BP559835   BP560233   BP560234   BP560239   BP560240   BX007228   BX007877   BX009464   BX011966   BX017262   BX021793   BX022130   BX022860   BX023892   BX028022   BX034476   BX036855   BX052420   BX072171   CA805095   CB305287   CK657452   CK660473   CK662228   CO152878   CO154485   CO154905   CO155119   CO156218   CO156659   CO157042   CO180324   CO180520   CO182132   CO183339   CO184161   CO184990   CO192038   CO193536   CO194643   CO195067   CO279136   CO337228   CO337484   CO337714   CO338214   DQ413222   DQ673413   DQ910360   EC072703   EC074926   EC220211   EC222779   EC237112   EC237847   EC237879   EC261031   EC261097   EC261800   EC262285   EC262528   EC264013   EC264278   EC264719   EC264937   EC265135   EC265392   EC267001   EC267031   EC267400   EU306853   EV575247   EV576355   EV577551   EV578328   EV578740   EV579951   EV581278   EV581433   EV581644   EV582275   EV582330   EV582928   EV583091   EV583308   EV583887   EV584073   EV584216   EV584419   EV585645   EV585680   EV585774   EV586153   EV586161   EV586619   EV588192   EV588686   EV588941   EV591107   EV592243   EV592302   EV592336   EV592640   EV593081   EV594680   EV594707   EV595048   EV595478   EV595814   EV595864   EV596079   EV596233   EV596529   EV597146   EV597405   EV598742   EV599119   EV599440   EV599727   EV599992   EV600198   EV600205   GU983913   X53059 CAA37227   X59943 CAA42568
UniProtKB/Swiss-Prot	P18101
UniProtKB/TrEMBL	Q7JYK1
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Cabrera et al., 1992) third instar larval stage   embryonic/larval fat body   (Cabrera et al., 1992) embryonic/larval hindgut   (Cabrera et al., 1992) embryonic/larval salivary gland   (Cabrera et al., 1992) imaginal disc   (Cabrera et al., 1992) Malpighian tubule   (Cabrera et al., 1992) oogenesis & adult stage | female   ovary   (Cabrera et al., 1992)
Additional Descriptive Data
	RpL40 transcripts are detected throughout development on northern blots. They are also detected in RNA from dissected tissues, namely larval Malpighian tubules and intestines, imaginal discs, fat body, salivary gland, and adult ovary. The level in ovaries is at least four times higher than that of the other dissected tissues. (Cabrera et al., 1992)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term	ribosome (Redman, 1994)
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0003941    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0003941 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely high expression to a trough of very high expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, at stages throughout the pupal period, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0003941 expression level Developmental Stage   Expression Level embryo 00-02hr    115783 embryo 02-04hr    158820 embryo 04-06hr    181099 embryo 06-08hr    173748 embryo 08-10hr    180515 embryo 10-12hr    195923 embryo 12-14hr    155791 embryo 14-16hr    161124 embryo 16-18hr    160878 embryo 18-20hr    163575 embryo 20-22hr    159169 embryo 22-24hr    173441 larva L1    231242 larva L2    193335 larva L3 12hr old    137182 larva L3 puffstage 1-2    121834 larva L3 puffstage 3-6    115803 larva L3 puffstage 7-9    137030 white prepupae new    132447 white prepupae 12hr    121871 white prepupae 24hr    119081 pupae 2d postWPP    107982 pupae 3d postWPP    83882 pupae 4d postWPP    78857 adult male 01day    63352 adult male 05day    59344 adult male 30day    78124 adult female 01day    147870 adult female 05day    132694 adult female 30day    130864 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (115783) embryo 02-04hr  (158820) embryo 04-06hr  (181099) embryo 06-08hr  (173748) embryo 08-10hr  (180515) embryo 10-12hr  (195923) embryo 12-14hr  (155791) embryo 14-16hr  (161124) embryo 16-18hr  (160878) embryo 18-20hr  (163575) embryo 20-22hr  (159169) embryo 22-24hr  (173441) larva L1  (231242) larva L2  (193335) larva L3 12hr old  (137182) larva L3 puffstage 1-2  (121834) larva L3 puffstage 3-6  (115803) larva L3 puffstage 7-9  (137030) white prepupae new  (132447) white prepupae 12hr  (121871) white prepupae 24hr  (119081) pupae 2d postWPP  (107982) pupae 3d postWPP  (83882) pupae 4d postWPP  (78857) adult male 01day  (63352) adult male 05day  (59344) adult male 30day  (78124) adult female 01day  (147870) adult female 05day  (132694) adult female 30day  (130864) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (115783) embryo 02-04hr  (158820) embryo 04-06hr  (181099) embryo 06-08hr  (173748) embryo 08-10hr  (180515) embryo 10-12hr  (195923) embryo 12-14hr  (155791) embryo 14-16hr  (161124) embryo 16-18hr  (160878) embryo 18-20hr  (163575) embryo 20-22hr  (159169) embryo 22-24hr  (173441) larva L1  (231242) larva L2  (193335) larva L3 12hr old  (137182) larva L3 puffstage 1-2  (121834) larva L3 puffstage 3-6  (115803) larva L3 puffstage 7-9  (137030) white prepupae new  (132447) white prepupae 12hr  (121871) white prepupae 24hr  (119081) pupae 2d postWPP  (107982) pupae 3d postWPP  (83882) pupae 4d postWPP  (78857) adult male 01day  (63352) adult male 05day  (59344) adult male 30day  (78124) adult female 01day  (147870) adult female 05day  (132694) adult female 30day  (130864) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (115783) embryo 02-04hr  (158820) embryo 04-06hr  (181099) embryo 06-08hr  (173748) embryo 08-10hr  (180515) embryo 10-12hr  (195923) embryo 12-14hr  (155791) embryo 14-16hr  (161124) embryo 16-18hr  (160878) embryo 18-20hr  (163575) embryo 20-22hr  (159169) embryo 22-24hr  (173441) larva L1  (231242) larva L2  (193335) larva L3 12hr old  (137182) larva L3 puffstage 1-2  (121834) larva L3 puffstage 3-6  (115803) larva L3 puffstage 7-9  (137030) white prepupae new  (132447) white prepupae 12hr  (121871) white prepupae 24hr  (119081) pupae 2d postWPP  (107982) pupae 3d postWPP  (83882) pupae 4d postWPP  (78857) adult male 01day  (63352) adult male 05day  (59344) adult male 30day  (78124) adult female 01day  (147870) adult female 05day  (132694) adult female 30day  (130864) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    115783 embryo 02-04hr    158820 embryo 04-06hr    181099 embryo 06-08hr    173748 embryo 08-10hr    180515 embryo 10-12hr    195923 embryo 12-14hr    155791 embryo 14-16hr    161124 embryo 16-18hr    160878 embryo 18-20hr    163575 embryo 20-22hr    159169 embryo 22-24hr    173441 larva L1    231242 larva L2    193335 larva L3 12hr old    137182 larva L3 puffstage 1-2    121834 larva L3 puffstage 3-6    115803 larva L3 puffstage 7-9    137030 white prepupae new    132447 white prepupae 12hr    121871 white prepupae 24hr    119081 pupae 2d postWPP    107982 pupae 3d postWPP    83882 pupae 4d postWPP    78857 adult male 01day    63352 adult male 05day    59344 adult male 30day    78124 adult female 01day    147870 adult female 05day    132694 adult female 30day    130864 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0003941 expression level Developmental Stage   Expression Level embryo 00-02hr    115783 embryo 02-04hr    158820 embryo 04-06hr    181099 embryo 06-08hr    173748 embryo 08-10hr    180515 embryo 10-12hr    195923 embryo 12-14hr    155791 embryo 14-16hr    161124 embryo 16-18hr    160878 embryo 18-20hr    163575 embryo 20-22hr    159169 embryo 22-24hr    173441 larva L1    231242 larva L2    193335 larva L3 12hr old    137182 larva L3 puffstage 1-2    121834 larva L3 puffstage 3-6    115803 larva L3 puffstage 7-9    137030 white prepupae new    132447 white prepupae 12hr    121871 white prepupae 24hr    119081 pupae 2d postWPP    107982 pupae 3d postWPP    83882 pupae 4d postWPP    78857 adult male 01day    63352 adult male 05day    59344 adult male 30day    78124 adult female 01day    147870 adult female 05day    132694 adult female 30day    130864 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (115783) embryo 02-04hr  (158820) embryo 04-06hr  (181099) embryo 06-08hr  (173748) embryo 08-10hr  (180515) embryo 10-12hr  (195923) embryo 12-14hr  (155791) embryo 14-16hr  (161124) embryo 16-18hr  (160878) embryo 18-20hr  (163575) embryo 20-22hr  (159169) embryo 22-24hr  (173441) larva L1  (231242) larva L2  (193335) larva L3 12hr old  (137182) larva L3 puffstage 1-2  (121834) larva L3 puffstage 3-6  (115803) larva L3 puffstage 7-9  (137030) white prepupae new  (132447) white prepupae 12hr  (121871) white prepupae 24hr  (119081) pupae 2d postWPP  (107982) pupae 3d postWPP  (83882) pupae 4d postWPP  (78857) adult male 01day  (63352) adult male 05day  (59344) adult male 30day  (78124) adult female 01day  (147870) adult female 05day  (132694) adult female 30day  (130864) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (115783) embryo 02-04hr  (158820) embryo 04-06hr  (181099) embryo 06-08hr  (173748) embryo 08-10hr  (180515) embryo 10-12hr  (195923) embryo 12-14hr  (155791) embryo 14-16hr  (161124) embryo 16-18hr  (160878) embryo 18-20hr  (163575) embryo 20-22hr  (159169) embryo 22-24hr  (173441) larva L1  (231242) larva L2  (193335) larva L3 12hr old  (137182) larva L3 puffstage 1-2  (121834) larva L3 puffstage 3-6  (115803) larva L3 puffstage 7-9  (137030) white prepupae new  (132447) white prepupae 12hr  (121871) white prepupae 24hr  (119081) pupae 2d postWPP  (107982) pupae 3d postWPP  (83882) pupae 4d postWPP  (78857) adult male 01day  (63352) adult male 05day  (59344) adult male 30day  (78124) adult female 01day  (147870) adult female 05day  (132694) adult female 30day  (130864) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (115783) embryo 02-04hr  (158820) embryo 04-06hr  (181099) embryo 06-08hr  (173748) embryo 08-10hr  (180515) embryo 10-12hr  (195923) embryo 12-14hr  (155791) embryo 14-16hr  (161124) embryo 16-18hr  (160878) embryo 18-20hr  (163575) embryo 20-22hr  (159169) embryo 22-24hr  (173441) larva L1  (231242) larva L2  (193335) larva L3 12hr old  (137182) larva L3 puffstage 1-2  (121834) larva L3 puffstage 3-6  (115803) larva L3 puffstage 7-9  (137030) white prepupae new  (132447) white prepupae 12hr  (121871) white prepupae 24hr  (119081) pupae 2d postWPP  (107982) pupae 3d postWPP  (83882) pupae 4d postWPP  (78857) adult male 01day  (63352) adult male 05day  (59344) adult male 30day  (78124) adult female 01day  (147870) adult female 05day  (132694) adult female 30day  (130864) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    115783 embryo 02-04hr    158820 embryo 04-06hr    181099 embryo 06-08hr    173748 embryo 08-10hr    180515 embryo 10-12hr    195923 embryo 12-14hr    155791 embryo 14-16hr    161124 embryo 16-18hr    160878 embryo 18-20hr    163575 embryo 20-22hr    159169 embryo 22-24hr    173441 larva L1    231242 larva L2    193335 larva L3 12hr old    137182 larva L3 puffstage 1-2    121834 larva L3 puffstage 3-6    115803 larva L3 puffstage 7-9    137030 white prepupae new    132447 white prepupae 12hr    121871 white prepupae 24hr    119081 pupae 2d postWPP    107982 pupae 3d postWPP    83882 pupae 4d postWPP    78857 adult male 01day    63352 adult male 05day    59344 adult male 30day    78124 adult female 01day    147870 adult female 05day    132694 adult female 30day    130864 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0003941    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0003941 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0003941 expression level Tissue   Expression Level Larval Central Nervous System    2283.325 Larval Midgut    3039.1 Larval Hindgut    3272.2 Larval Malpighian Tubules    3560.2 Larval Fat Body    5630.2 Larval Salivary Gland    5945 Larval Trachea    5038.825 Larval Carcass    3831.8 Adult Head    3688.1 Adult Eye    5400.225 Adult Brain    2584.5 Adult Thoracic-Abdominal Ganglion    3451.3 Adult Crop    4395.3 Adult Midgut    4063.7 Adult Hindgut    3992.3 Adult Malpighian Tubules    2091.1 Adult Fat Body    4330.5 Adult Salivary Gland    7782.2 Adult Heart    5213.825 Adult VirginFemale Spermatheca    4237.6 Adult InseminatedFemale Spermatheca    4234.9 Adult Ovary    2634.7 Adult Testis    815.5 Adult Male Accessory Gland    6169.8 Adult Carcass    4201.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (2283.325) Larval Midgut  (3039.1) Larval Hindgut  (3272.2) Larval Malpighian Tubules  (3560.2) Larval Fat Body  (5630.2) Larval Salivary Gland  (5945) Larval Trachea  (5038.825) Larval Carcass  (3831.8) Adult Head  (3688.1) Adult Eye  (5400.225) Adult Brain  (2584.5) Adult Thoracic-Abdominal Ganglion  (3451.3) Adult Crop  (4395.3) Adult Midgut  (4063.7) Adult Hindgut  (3992.3) Adult Malpighian Tubules  (2091.1) Adult Fat Body  (4330.5) Adult Salivary Gland  (7782.2) Adult Heart  (5213.825) Adult VirginFemale Spermatheca  (4237.6) Adult InseminatedFemale Spermatheca  (4234.9) Adult Ovary  (2634.7) Adult Testis  (815.5) Adult Male Accessory Gland  (6169.8) Adult Carcass  (4201.1) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (2283.325) Larval Midgut  (3039.1) Larval Hindgut  (3272.2) Larval Malpighian Tubules  (3560.2) Larval Fat Body  (5630.2) Larval Salivary Gland  (5945) Larval Trachea  (5038.825) Larval Carcass  (3831.8) Adult Head  (3688.1) Adult Eye  (5400.225) Adult Brain  (2584.5) Adult Thoracic-Abdominal Ganglion  (3451.3) Adult Crop  (4395.3) Adult Midgut  (4063.7) Adult Hindgut  (3992.3) Adult Malpighian Tubules  (2091.1) Adult Fat Body  (4330.5) Adult Salivary Gland  (7782.2) Adult Heart  (5213.825) Adult VirginFemale Spermatheca  (4237.6) Adult InseminatedFemale Spermatheca  (4234.9) Adult Ovary  (2634.7) Adult Testis    815.5 Adult Male Accessory Gland  (6169.8) Adult Carcass  (4201.1) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    2283.325 Larval Midgut    3039.1 Larval Hindgut    3272.2 Larval Malpighian Tubules    3560.2 Larval Fat Body    5630.2 Larval Salivary Gland    5945 Larval Trachea    5038.825 Larval Carcass    3831.8 Adult Head    3688.1 Adult Eye    5400.225 Adult Brain    2584.5 Adult Thoracic-Abdominal Ganglion    3451.3 Adult Crop    4395.3 Adult Midgut    4063.7 Adult Hindgut    3992.3 Adult Malpighian Tubules    2091.1 Adult Fat Body    4330.5 Adult Salivary Gland    7782.2 Adult Heart    5213.825 Adult VirginFemale Spermatheca    4237.6 Adult InseminatedFemale Spermatheca    4234.9 Adult Ovary    2634.7 Adult Testis    815.5 Adult Male Accessory Gland    6169.8 Adult Carcass    4201.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0003941 expression level Tissue   Expression Level Larval Central Nervous System    2283.325 Larval Midgut    3039.1 Larval Hindgut    3272.2 Larval Malpighian Tubules    3560.2 Larval Fat Body    5630.2 Larval Salivary Gland    5945 Larval Trachea    5038.825 Larval Carcass    3831.8 Adult Head    3688.1 Adult Eye    5400.225 Adult Brain    2584.5 Adult Thoracic-Abdominal Ganglion    3451.3 Adult Crop    4395.3 Adult Midgut    4063.7 Adult Hindgut    3992.3 Adult Malpighian Tubules    2091.1 Adult Fat Body    4330.5 Adult Salivary Gland    7782.2 Adult Heart    5213.825 Adult VirginFemale Spermatheca    4237.6 Adult InseminatedFemale Spermatheca    4234.9 Adult Ovary    2634.7 Adult Testis    815.5 Adult Male Accessory Gland    6169.8 Adult Carcass    4201.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (2283.325) Larval Midgut  (3039.1) Larval Hindgut  (3272.2) Larval Malpighian Tubules  (3560.2) Larval Fat Body  (5630.2) Larval Salivary Gland  (5945) Larval Trachea  (5038.825) Larval Carcass  (3831.8) Adult Head  (3688.1) Adult Eye  (5400.225) Adult Brain  (2584.5) Adult Thoracic-Abdominal Ganglion  (3451.3) Adult Crop  (4395.3) Adult Midgut  (4063.7) Adult Hindgut  (3992.3) Adult Malpighian Tubules  (2091.1) Adult Fat Body  (4330.5) Adult Salivary Gland  (7782.2) Adult Heart  (5213.825) Adult VirginFemale Spermatheca  (4237.6) Adult InseminatedFemale Spermatheca  (4234.9) Adult Ovary  (2634.7) Adult Testis  (815.5) Adult Male Accessory Gland  (6169.8) Adult Carcass  (4201.1) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (2283.325) Larval Midgut  (3039.1) Larval Hindgut  (3272.2) Larval Malpighian Tubules  (3560.2) Larval Fat Body  (5630.2) Larval Salivary Gland  (5945) Larval Trachea  (5038.825) Larval Carcass  (3831.8) Adult Head  (3688.1) Adult Eye  (5400.225) Adult Brain  (2584.5) Adult Thoracic-Abdominal Ganglion  (3451.3) Adult Crop  (4395.3) Adult Midgut  (4063.7) Adult Hindgut  (3992.3) Adult Malpighian Tubules  (2091.1) Adult Fat Body  (4330.5) Adult Salivary Gland  (7782.2) Adult Heart  (5213.825) Adult VirginFemale Spermatheca  (4237.6) Adult InseminatedFemale Spermatheca  (4234.9) Adult Ovary  (2634.7) Adult Testis    815.5 Adult Male Accessory Gland  (6169.8) Adult Carcass  (4201.1) Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    2283.325 Larval Midgut    3039.1 Larval Hindgut    3272.2 Larval Malpighian Tubules    3560.2 Larval Fat Body    5630.2 Larval Salivary Gland    5945 Larval Trachea    5038.825 Larval Carcass    3831.8 Adult Head    3688.1 Adult Eye    5400.225 Adult Brain    2584.5 Adult Thoracic-Abdominal Ganglion    3451.3 Adult Crop    4395.3 Adult Midgut    4063.7 Adult Hindgut    3992.3 Adult Malpighian Tubules    2091.1 Adult Fat Body    4330.5 Adult Salivary Gland    7782.2 Adult Heart    5213.825 Adult VirginFemale Spermatheca    4237.6 Adult InseminatedFemale Spermatheca    4234.9 Adult Ovary    2634.7 Adult Testis    815.5 Adult Male Accessory Gland    6169.8 Adult Carcass    4201.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    3688.1   NA  Eye    5400.225   NA  Brain    2584.5   2283.325  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    3451.3   NA  Crop    4395.3   3039.1  Midgut    4063.7   3272.2  Hindgut    3992.3   3560.2  Malpighian Tubules    2091.1   5630.2  Fat Body    4330.5   5945  Salivary Gland    7782.2   NA  Heart    5213.825   5038.825  Trachea    NA   NA  VirginFemale Spermatheca    4237.6   NA  InseminatedFemale Spermatheca    4234.9   NA  Ovary    2634.7   NA  Testis    815.5   NA  Male Accessory Gland    6169.8   3831.8  Carcass    4201.1 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_22
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003941 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2960-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | pupal stage, with Scer\GAL4pnr-MD237 RpL40GD9867 semi-lethal | pupal stage, with Scer\GAL4pnr-MD237 RpL40GD9867 Other Phenotypes Allele visible, with Scer\GAL4pnr-MD237 RpL40GD9867 Phenotype manifest in Allele mesothoracic tergum, with Scer\GAL4pnr-MD237 RpL40GD9867
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of RpL40 Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of RpL40 Class Mutagen Stocks Known lesion RpL40GD9867 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes RpL40GL00339 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes RpL40KK107503 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)BSC217 (Christensen and Cook, 2006.12.5) Df(2L)BSC218 (Christensen and Cook, 2006.12.5) Df(2L)Exel8011 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD9867} NA P{KK107503} NA P{TRiP.GL00339} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 8 unique terms )
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function ( 0 terms)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
cytosolic large ribosomal subunit inferred from direct assay (Redman, 1994) lipid particle inferred from direct assay (Beller et al., 2006) microtubule associated complex inferred from direct assay (Hughes et al., 2008)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
structural constituent of ribosome inferred from sequence or structural similarity with human UBA52 (FlyBase, 1992-) non-traceable author statement (Swiss-Prot Project Members, 1990.11.1) traceable author statement (Cabrera et al., 1990)
Biological Process
CV term Evidence References
protein modification process inferred from sequence or structural similarity (Cabrera et al., 1990) translation inferred from sequence or structural similarity with human UBA52 (FlyBase, 1992-) traceable author statement (Cabrera et al., 1990) ubiquitin-dependent protein catabolic process inferred from sequence or structural similarity (Cabrera et al., 1990)
Cellular Component
CV term Evidence References
cytosolic large ribosomal subunit inferred from sequence or structural similarity with human UBA52 (FlyBase, 1992-) ribosome non-traceable author statement (Swiss-Prot Project Members, 1990.11.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions RpL40 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 59826 DroID - A comprehensive database of gene and protein interactions. • FBgn0003941 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33629
Orthologs
Genome-wide drosophilid orthologs	Dana\GF15052 Dere\GG24988 Dgri\GH10063 Dmoj\GI16482 Dper\GL13989 Dpse\GA15543 Dsec\GM18458 Dsim\GD12014 Dvir\GJ16220 Dwil\GK24609 Dyak\RpL40
Curated drosophilid orthologs	Dbuz\Ubi-f52   Dpse\GA15543   Drep\Ubi-f52   Dyak\RpL40
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL006511-PA Aedes aegypti (mosquito) AGAP007927-PA Anopheles gambiae (mosquito) XP_001120521.1 Apis mellifera (honey bee) NP_001119684.1 Acyrthosiphon pisum (pea aphid) At2g36170.1 Arabidopsis thaliana (wall cress) At3g52590.1 Arabidopsis thaliana (wall cress) 17228 Batrachochytrium dendrobatidis (chytrid fungus) XP_001902301.1 Brugia malayi (roundworm nematode) BGIBMGA010604-PA Bombyx mori (silk worm) ENSBTAP00000010176 Bos taurus (bovine) CN18707 Caenorhabditis brenneri (small nematode) CBP03773 Caenorhabditis briggsae (nematode) CE15495 Caenorhabditis elegans (worm) ENSCAFP00000021714 Canis familiaris (dog) CAGL0G02475g Candida glabrata (haploid yeast) Chro.70260 Cryptosporidium hominis (obligate parasite) ENSCINP00000010307 Ciona intestinalis (sea squirt) JA10960 Caenorhabditis japonica (nematode) CMC045C Cyanidioschyzon merolae (red alga) cn01327 Cryptococcus neoformans (yeast-like fungus) cgd7_2280 Cryptosporidium parvum (protozoan parasite) CPIJ002413 Culex pipens (mosquito) ENSCPOP00000000308 Cavia porcellus (guinea pig) 140045 Chlamidomonas reinhardtii (green alga) 191044 Chlamidomonas reinhardtii (green alga) RP22523 Caenorhabditis remanei (nematode) ENSCSAVP00000003728 Ciona savignyi (sedentary tunicate) DDB0214925 Dictyostelium discoideum (amoeba) ENSDARP00000060744 Danio rerio (zebra fish) ENSECAP00000018080 Equus caballus (horse) XP_650163 Entamoeba histolytica (anaerobic protozoan) XP_650527 Entamoeba histolytica (anaerobic protozoan) XP_654066 Entamoeba histolytica (anaerobic protozoan) XP_655029 Entamoeba histolytica (anaerobic protozoan) XP_655179 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000010640 Gymnopilus aculeatus (mushroom) GL50803_7110 Giardia lamblia (flagellated protozoan) ENSP00000386142 Homo sapiens (human) ISCW020697-PA Ixodes scapularis (deer tick) KLLA0A00616g Kluyveromyces lactis (yeast) 126004 Lottia gigantea (owl limpet) 233138 Lottia gigantea (owl limpet) LmjF31.1900 Leishmania major (virus) LmjF31.2030 Leishmania major (virus) 15807 Monocosta brevicollis (choanoflagellate) ENSMODP00000004277 Monodelphis domestica (gray opossum) ENSMMUP00000021162 Macaca mulatta (rhesus monkey) ENSMUSP00000086852 Mus musculus (house mouse) ENSMUSP00000113804 Mus musculus (house mouse) XP_001600310.1 Nasonia vitripennis (wasp) ENSOANP00000028942 Ornithorynchus anatinus (platypus) ENSORLP00000010731 Oryzias latipes (japanese killifish) LOC_Os03g13170.1 Oryza sativa (asian rice) LOC_Os09g39500.1 Oryza sativa (asian rice) 18605 Ostreococcus tauri (green alga) PF13_0346 Plasmodium falciparum (protozoal parasite) PHUM004352-PA Pediculus humanus (human body louse) PP14494 Pristionchus pacificus (nematode) 120423 Physcomitrella patens (moss) 146255 Physcomitrella patens (moss) 147888 Physcomitrella patens (moss) 148837 Physcomitrella patens (moss) 151140 Physcomitrella patens (moss) 151221 Physcomitrella patens (moss) ENSPPYP00000010917 Pongo pygmaeus (orangutan) 71367 Phytophthora ramorum (sudden oak death pathogen) 109390 Phytophthora sojae (root rot pathogen) 728795 Populus trichocarpa (black cottonwood) 835053 Populus trichocarpa (black cottonwood) ENSPTRP00000032468 Pan troglodytes (chimpanzee) PVX_115255 Plasmodium vivax (protozoal parasite) ENSRNOP00000027073 Rattus norvegicus (norway rat) 4793830 Sorghum bicolor (sorghum) YIL148W Saccharomyces cerevisiae (budding yeast) YKR094C Saccharomyces cerevisiae (budding yeast) Smp_089430 Schistosoma mansoni (trematode parasite) SPAC11G7.04 Schizosaccharomyces pombe (fission yeast) SPAC1805.12c Schizosaccharomyces pombe (fission yeast) XP_789778.1 Strongylocentrotus purpuratus (purple sea urchin) 33280 Trichoplax adhaerens (metazoa) TA16165 Theileria annulata (apicomplexan parasite) XP_968519.1 Tribolium castaneum (red flour beetle) ENSTNIP00000013085 Tetraodon nigroviridis (green spotted pufferfish) TP01_1070 Theileria parva (parasitic protozoan) 31064 Thalassiosira pseudonana (marine diatom) ENSTRUP00000009801 Takifugu rubripes (pufferfish Takifugu) 3689.m00134 Tetrahymena thermophila (ciliate protozoa) 80892.m00183 Trichomonas vaginalis (parasitic flagellated protozoan) 83996.m00254 Trichomonas vaginalis (parasitic flagellated protozoan) 91676.m00035 Trichomonas vaginalis (parasitic flagellated protozoan) 96044.m00336 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000050158 Xenopus tropicalis (frog) YALI0F08745g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV18963 ISCW020697 FBgn0237973 FBgn0068068 FBgn0226569 FBgn0203405 FBgn0183753 FBgn0173365 FBgn0075560 FBgn0151594 FBgn0139230 FBgn0117544 FBgn0117117 FBgn0092077 CPIJ013710 CPIJ002413 BGIBMGA010604 ACYPI000076 GB18108 AGAP007927 AAEL006511 PHUM602270 GLEAN_07754
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
Bloomington	35417 y1 sc* v1; P{TRiP.GL00339}attP2
VDRC	v108730 P{KK107503}VIE-260B v25466 w1118; P{GD9867}v25466
Genomic Clones ( 1 )
	BACR11D14 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 251 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE10554
Other clones	yak-ad_RpL40 yak-em_RpL40
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH01145 GH01980 GH04192 GH05893 GH07647 GH08118 GH09744 GH11590 GH20529 GH20932 GH25852 GH26467 GH27428 GM15868 GM19792 GM24377 GM29146 GM30375 GM31159 HL08114 LD27845 LP10276 LP19083 LP22278 LP23760 RE10351 RE18714 RE28968 RE37553 RE38774 RE57683 RE63918 RH10945 RH13641 RH23636 RH40310 SD03866 SD11072 SD14856 SD15605 SD24951 SD27495
Other clones	bs70a11 Dmel_dig_001163_0628_0538 Dmel_dig_001784_0652_3782 Dmel_dig_002247_0586_2534 Dmel_dig_002335_0617_2205 Dmel_dig_004148_0678_0720 Dmel_dig_004821_0684_3702 Dmel_dig_005200_0711_0822 Dmel_dig_006523_0590_1687 Dmel_dig_008681_0708_2205 Dmel_dig_008684_0641_1842 Dmel_dig_009838_0644_3157 Dmel_dig_012254_0596_2739 Dmel_dig_013030_0684_2099 Dmel_dig_013441_0670_3315 Dmel_dig_013602_0658_3393 Dmel_dig_014863_0713_2552 Dmel_dig_015802_0595_0973 Dmel_dig_015902_0675_1876 Dmel_dig_016097_0693_0729 Dmel_dig_016186_0709_2765 Dmel_dig_016599_0635_2751 Dmel_dig_016951_0657_2327 Dmel_dig_017382_0638_0986 Dmel_neb_001875_0444_0360 Dmel_neb_001880_0667_0330 Dmel_neb_004245_0626_3417 Dmel_neb_005400_0850_1280 Dmel_neb_005999_0073_2711 Dmel_neb_006716_0937_2903 Dmel_neb_007213_0698_1009 Dmel_neb_009936_0875_3575 Dmel_neb_010252_0609_2715 Dmel_neb_010686_0656_3094 Dmel_neb_010831_0626_2749 Dmel_neb_011399_0605_0458 Dmel_neb_011709_0914_1578 Dmel_neb_011854_0945_3220 Dmel_neb_012067_0944_0776 Dmel_neb_012158_0190_1044 Dmel_neb_013336_0138_3071 Dmel_neb_013376_0694_1436 Dmel_neb_013556_0901_0579 Dmel_neb_013781_0140_3535 Dmel_neb_014467_0940_0461 Dmel_neb_015007_0596_2925 Dmel_neb_015148_0581_2199 Dmel_neb_015254_0695_2053 Dmel_neb_015646_0912_0814 Dmel_neb_015665_0682_2118 Dmel_neb_015740_0563_2769 Dmel_neb_016375_0942_2982 EC01411 EC02001 EC22146 EC25489 EC27250 EC29049 EC32677 EC36333 EC38950 EC39657 EK133617 EN00640 EN04224 EN05017 EN05418 EN07604 EN08516 EN09825 EN14110 EN14636 EN15139 EN16223 ESG0116c.B21_B04 FGA006C11 FGA007C04 FGA011B07 FGA011H06 FGB002C12 FGB002D03 FGC003C01 FGC004F03 FGC005D02 FGC006E08 FGC007D04 FGC007G07 FGC010G10 FGC011D06 FGC011G12 FGC015E10 FGC017A12 FGC017G06 FGC018C03 FGC018C08 FGC018H09 FGC021E12 FGC022C08 FGC022F04 FGC023F10 FGC025H10 FGC026F08 FGC027A01 FGC027A08 FGC027A11 FGC028D10 FGC030A01 FGC030H08 FGC031F12 FGC032B04 FGH001E12 FGH102A04 FGH103B12 FGH104F11 FGH104H07 FGH105C01 FGH105C04 FGH107G08 FGH108B09 FGH109C09 FGH109G08 FGH109H08 FGH109H10 FGH110C01 FGH110F04 FGH112A05 FGH112C10 FGH113H04 FGH114C06 FGH114E12 FGH114F01 FGH116D01 FGH116F12 FGH117F03 FGH117F08 FGH118D04 FGH118F10 FGH118G06 FGH119G03 FGH120C04 FGH122E07 FGH123B05 FGH123B11 FGH124C10 FGH125C09 FGH125D06 FGH125E05 FGH126H08 FGH128H03 FGH128H08 FGM001C06 FGM003F01 FGM101E01 FGM102B12 FGM102F02 FGM104H03 FGM104H08 FGM105F11 FGM105G12 FGM206H01 FGM207G02 FGM207G10 FGM208D03 FGM208E10 FGM209F10 FGM211A07 FGM213F05 FGM213G05 FGM213G06 FGM214E01 FGM215A06 FGM215C05 FGM216B12 FGM216C04 FGM217A02 FGM218C09 FGM218G02 FGM219H11 FGM227H03 FGM231A01 FGM233G06 FGM234E12 FGM234H11 FGM235C08 FGM235C12 FGM235F06 FGM237C02 FGM302F12 FGM304H02 FGM306A07 FGM309C05 FGM310H11 FGM316H03 FGM318F01 FGM319A09 FGM320C03 FGM321A12 FGM321C06 FGM321G08 FGM321H02 FGM322G02 FGM323B11 FGM325D07 FGM325D10 GH05920 Nfly-102
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0003941 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33629
Antibody Information
	polyclonal (Redman, 1994)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: RpL40 BcDNA:RE10554 (FlyBase, 1996-)
Additional comments	"RpL40" likely corresponds to "M(2)24D". (Marygold et al., 2007) Source for merge of RpL40 BcDNA:RE10554 was a shared cDNA (date:030728). (FlyBase, 1996-)
Other Comments
	Likely Minute gene. (Marygold et al., 2007) Deletions removing RpL40 but no other cytoplasmic ribosomal protein-encoding genes show Minute phenotypes. (Marygold et al., 2007) RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells. (Boutros et al., 2004) Antibody staining of polytene chromosomes shows that ubiquitin is mainly associated with the compact and stabilized structure that forms the bands rather than with the more decondensed and destabilized protein-DNA structure that forms interbands and puffs. (Izquierdo, 1994) Ubi-f52 gene organization and expression has been determined. (Cabrera et al., 1992) A RpL40 cDNA has been cloned and sequenced. (Cabrera et al., 1990)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057428 RefSeq (Proteins) • NP_476776 DDBJ / EMBL / GenBank • AAF51034 AAL68264 AC004380 AC092217 AY075451 BI169393 CAA37227 CAA42568 X53059 X59943 Entrez Gene - A searchable database of RefSeq genes. • 33629 UniProtKB/Swiss-Prot • P18101 UniProtKB/TrEMBL • Q7JYK1
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Ubiquitin (IPR000626) Ribosomal protein L40e (IPR001975) Ubiquitin conserved site (IPR019954) Ubiquitin supergroup (IPR019955) Ubiquitin subgroup (IPR019956)
Linkouts
	BioGRID - A database of protein and genetic interactions • 59826 DroID - A comprehensive database of gene and protein interactions. • FBgn0003941 DRSC - Results from RNAi screens. • FBgn0003941 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003941 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2960-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0003941 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33629 InParanoid A subset of ortholog calls from InParanoid. • AAEL006511-PA Aedes aegypti (mosquito) AGAP007927-PA Anopheles gambiae (mosquito) XP_001120521.1 Apis mellifera (honey bee) NP_001119684.1 Acyrthosiphon pisum (pea aphid) At2g36170.1 Arabidopsis thaliana (wall cress) At3g52590.1 Arabidopsis thaliana (wall cress) 17228 Batrachochytrium dendrobatidis (chytrid fungus) XP_001902301.1 Brugia malayi (roundworm nematode) BGIBMGA010604-PA Bombyx mori (silk worm) ENSBTAP00000010176 Bos taurus (bovine) CN18707 Caenorhabditis brenneri (small nematode) CBP03773 Caenorhabditis briggsae (nematode) CE15495 Caenorhabditis elegans (worm) ENSCAFP00000021714 Canis familiaris (dog) CAGL0G02475g Candida glabrata (haploid yeast) Chro.70260 Cryptosporidium hominis (obligate parasite) ENSCINP00000010307 Ciona intestinalis (sea squirt) JA10960 Caenorhabditis japonica (nematode) CMC045C Cyanidioschyzon merolae (red alga) cn01327 Cryptococcus neoformans (yeast-like fungus) cgd7_2280 Cryptosporidium parvum (protozoan parasite) CPIJ002413 Culex pipens (mosquito) ENSCPOP00000000308 Cavia porcellus (guinea pig) 140045 Chlamidomonas reinhardtii (green alga) 191044 Chlamidomonas reinhardtii (green alga) RP22523 Caenorhabditis remanei (nematode) ENSCSAVP00000003728 Ciona savignyi (sedentary tunicate) DDB0214925 Dictyostelium discoideum (amoeba) ENSDARP00000060744 Danio rerio (zebra fish) ENSECAP00000018080 Equus caballus (horse) XP_650163 Entamoeba histolytica (anaerobic protozoan) XP_650527 Entamoeba histolytica (anaerobic protozoan) XP_654066 Entamoeba histolytica (anaerobic protozoan) XP_655029 Entamoeba histolytica (anaerobic protozoan) XP_655179 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000010640 Gymnopilus aculeatus (mushroom) GL50803_7110 Giardia lamblia (flagellated protozoan) ENSP00000386142 Homo sapiens (human) ISCW020697-PA Ixodes scapularis (deer tick) KLLA0A00616g Kluyveromyces lactis (yeast) 126004 Lottia gigantea (owl limpet) 233138 Lottia gigantea (owl limpet) LmjF31.1900 Leishmania major (virus) LmjF31.2030 Leishmania major (virus) 15807 Monocosta brevicollis (choanoflagellate) ENSMODP00000004277 Monodelphis domestica (gray opossum) ENSMMUP00000021162 Macaca mulatta (rhesus monkey) ENSMUSP00000086852 Mus musculus (house mouse) ENSMUSP00000113804 Mus musculus (house mouse) XP_001600310.1 Nasonia vitripennis (wasp) ENSOANP00000028942 Ornithorynchus anatinus (platypus) ENSORLP00000010731 Oryzias latipes (japanese killifish) LOC_Os03g13170.1 Oryza sativa (asian rice) LOC_Os09g39500.1 Oryza sativa (asian rice) 18605 Ostreococcus tauri (green alga) PF13_0346 Plasmodium falciparum (protozoal parasite) PHUM004352-PA Pediculus humanus (human body louse) PP14494 Pristionchus pacificus (nematode) 120423 Physcomitrella patens (moss) 146255 Physcomitrella patens (moss) 147888 Physcomitrella patens (moss) 148837 Physcomitrella patens (moss) 151140 Physcomitrella patens (moss) 151221 Physcomitrella patens (moss) ENSPPYP00000010917 Pongo pygmaeus (orangutan) 71367 Phytophthora ramorum (sudden oak death pathogen) 109390 Phytophthora sojae (root rot pathogen) 728795 Populus trichocarpa (black cottonwood) 835053 Populus trichocarpa (black cottonwood) ENSPTRP00000032468 Pan troglodytes (chimpanzee) PVX_115255 Plasmodium vivax (protozoal parasite) ENSRNOP00000027073 Rattus norvegicus (norway rat) 4793830 Sorghum bicolor (sorghum) YIL148W Saccharomyces cerevisiae (budding yeast) YKR094C Saccharomyces cerevisiae (budding yeast) Smp_089430 Schistosoma mansoni (trematode parasite) SPAC11G7.04 Schizosaccharomyces pombe (fission yeast) SPAC1805.12c Schizosaccharomyces pombe (fission yeast) XP_789778.1 Strongylocentrotus purpuratus (purple sea urchin) 33280 Trichoplax adhaerens (metazoa) TA16165 Theileria annulata (apicomplexan parasite) XP_968519.1 Tribolium castaneum (red flour beetle) ENSTNIP00000013085 Tetraodon nigroviridis (green spotted pufferfish) TP01_1070 Theileria parva (parasitic protozoan) 31064 Thalassiosira pseudonana (marine diatom) ENSTRUP00000009801 Takifugu rubripes (pufferfish Takifugu) 3689.m00134 Tetrahymena thermophila (ciliate protozoa) 80892.m00183 Trichomonas vaginalis (parasitic flagellated protozoan) 83996.m00254 Trichomonas vaginalis (parasitic flagellated protozoan) 91676.m00035 Trichomonas vaginalis (parasitic flagellated protozoan) 96044.m00336 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000050158 Xenopus tropicalis (frog) YALI0F08745g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33629 modMine - Data generated by the modENCODE project. • FBgn0003941 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV18963 ISCW020697 FBgn0237973 FBgn0068068 FBgn0226569 FBgn0203405 FBgn0183753 FBgn0173365 FBgn0075560 FBgn0151594 FBgn0139230 FBgn0117544 FBgn0117117 FBgn0092077 CPIJ013710 CPIJ002413 BGIBMGA010604 ACYPI000076 GB18108 AGAP007927 AAEL006511 PHUM602270 GLEAN_07754
Synonyms & Secondary IDs ( 16 )
Reported As
Symbol Synonym	BcDNA:RE10554   CEP52 (Redman, 1994) CG2960 (Marygold et al., 2007, Keleman et al., 2009.8.5, Hughes et al., 2008, Ni et al., 2011.7.19, Cammarato et al., 2011) DUb52 (Cabrera et al., 1992) Dub52   RpL40 (Beller et al., 2006, Marygold, 2007.1.12, Christensen and Cook, 2006.12.5, Christensen and Cook, 2006.12.5, Christensen and Cook, 2007.5.8, Langille and Clark, 2007, Arancio et al., 2010, Marygold et al., 2007) Rpl40 (Gorchakov et al., 2009) Ub52 (Barrio, 1991.6.4) Ubi-f   Ubi-f52   Ubiq (Wesley and Mok, 2003)
Name Synonym	Ribosomal protein L40 (Cammarato et al., 2011) Ubiquitin (Wesley and Mok, 2003) ubiquitin (Murphey and Godenschwege, 2002) ubiquitin 52-AA extension protein (Cabrera, 1990.5.23) Ubiquitin fusion 52
Secondary FlyBase IDs
	FBgn0061410
References ( 39 )
Generate a list of	All references relating to this gene ( 39 )
List References by type	Research paper  ( 13 ) Supplementary material  ( 8 ) Review  ( 1 ) Personal communication to FlyBase  ( 8 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 2 ) Protein sequence record  ( 1 ) Computer file  ( 2 ) Curated genome annotation  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers ( 2 )
	Casad et al., 2011, Genetics 189(3): 861--870 Cardiomyopathy Is Associated with Ribosomal Protein Gene Haplo-Insufficiency in Drosophila melanogaster. [FBrf0216591] Arancio et al., 2010, Genetics 185(1): 129--140 The nucleosome remodeling factor ISWI functionally interacts with an evolutionarily conserved network of cellular factors. [FBrf0213976] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...