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Gene Dmel\Ubi-p63E

General Information
Symbol	Dmel\Ubi-p63E	Species	D. melanogaster
Name	Ubiquitin-63E	Annotation symbol	CG11624
Feature type	protein_coding_gene	FlyBase ID	FBgn0003943
Gene Model Status	Current	Stock availability	5 publicly available
Also Known As	Ub, ubi63E, Ubi-p
Genomic Location
Chromosome (arm)	3L	Recombination map	3-
Cytogenetic map	63F5-63F5	Sequence location	3L:3,899,259..3,903,184 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Ubiquitin-63E is referred to in FlyBase by the symbol Dmel\Ubi-p63E (CG11624, FBgn0003943). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: cellular process; phagocytosis, engulfment. 11 alleles are reported. No phenotypic data is available. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: Ubiquitin; Ubiquitin conserved site; Ubiquitin subgroup; Ubiquitin supergroup. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 06-18 hour embryonic stages, during late larval stages, at stages throughout the pupal period, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: High levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1624230_s_at completely aligns to an exonic region of only a subset of 2 of the 3 FlyBase-annotated transcript isoforms of Ubi-p63E. Gene sequence location is 3L:3899259..3903184.
User Contributed Data
	Beta version, feedback welcome
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	Ubi-p: Ubiquitin-polymeric Structural gene for ubiquitin (Arribas et al., 1988); structure and expression described by Lee et al. (1988). Threefold increase in level of gene by heat shock. An Ubi-p - lacZ fusion gene introduced by germ line transformation has been expressed at high levels at all life stages tested (embryonic, larval, pupal, and adult).
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 63F5-63F5   Limits computationally determined from genome sequence between P{PZ}kst01318 and P{PZ}Sc205634
Experimentally Determined Cytological Location
Cytogenetic map Notes References 63F2-63F4   (determined by in situ hybridisation)   (Ranz et al., 1997) 63E-63E   (determined by in situ hybridisation)   (Izquierdo, 1994) 63F-63F   (determined by in situ hybridisation)   (Arribas et al., 1986)
Experimentally Determined Recombination Data
Location	3-
Left of (cM)
Right of (cM)
Notes	Same map position as 63F early ecdysone-induced puff.
Gene Model & Products
Please see the GBrowse view of Dmel\Ubi-p63E for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.46 Low-frequency RNA-Seq exon junction(s) not annotated. Annotated transcripts do not represent all supported alternative splices within 5' UTR. Apparent introns not annotated: probable artifact due to repetitive sequence.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Ubi-p63E-RA FBtr0073177  NM_168043   2521   763 Ubi-p63E-RB FBtr0073178  NM_079185   2759   763 Ubi-p63E-RC FBtr0073179  NM_206272   2710   763 Ubi-p63E-RD FBtr0333142  NM_001274454   2624   763
Additional Transcript Data & Comments
Reported size (kB)	4.4 (northern blot) (Lee et al., 1988)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Ubi-p63E-PA   FBpp0073034   85.8   763   7.95     NP_728908   AAF47806 Ubi-p63E-PB   FBpp0073035   85.8   763   7.95     NP_523909   AAG22241 Ubi-p63E-PC   FBpp0089269   85.8   763   7.95     NP_995994   AAS64964 Ubi-p63E-PD   FBpp0305348   85.8   763   7.95     NP_001261383   AGB94078
Additional Polypeptide Data & Comments
Reported size (kDa)	231 (aa) (Lee et al., 1988)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Ubiquitin (IPR000626) Ubiquitin conserved site (IPR019954) Ubiquitin supergroup (IPR019955) Ubiquitin subgroup (IPR019956) PDB - Protein Data Bank. An information portal to biological macromolecular structures • 1AAR 1TBE 1UBI 1UBQ
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA440076   AA698638   AE014296 AAF47806   AE014296 AAG22241   AE014296 AAS64964   AE014296 AGB94078   AI107773   AI238396   AI514032   AI944530   AI945821   AI946105   AI946266   AI946317   AI946403   AI946482   AK254155   AK284275   AX093912   AY075451   AY118459   AY118702 AAM50562   AY231640   AY231778   AY232047   AY232172   AY433017   AY433575   AY826135   BE975009   BE975975   BE976043   BE976265   BE976707   BE976916   BE977201   BE977250   BE977278   BE977864   BE978067   BE978471   BE978988   BE979037   BE979073   BG631888   BG631889   BG631890   BG631891   BG631892   BG631893   BG631894   BG631895   BG631896   BG631897   BG631898   BG631899   BG631901   BG631903   BG631904   BG631906   BG631908   BG632353   BG632406   BG633117   BG633604   BG633617   BG633685   BG633696   BG633697   BG635190   BG636123   BG637543   BG637593   BG637663   BG638293   BG661098   BG661099   BI228509   BI230572   BI353774   BI355574   BI370248   BI373289   BP546121   BP560287   BT044587   BT099554   BX007877   BX009464   BX020423   BX021793   BX022130   BX022860   BX027102   BX028022   BX046701   BX052420   BX063279   CA804957   CA805489   CA805677   CA806661   CA807344   CL528006   CO299452   CZ469563   CZ480484   CZ480875   DQ413222   DQ673413   DQ673439   EC068336   EC199876   EC217255   EC239093   EC245552   EC250428   EC261493   EC261613   EC263375   EC265360   EC265409   EF070483   ES692120   EU306853   EV575566   EV583353   EV584496   EV585151   EV590125   EV591196   EV593570   EV596153   M22428 AAA28997   M33013 AAA28999   M33014 AAA29000   M33015 AAA29001   M33016 AAA29002   M33017 AAA29003   M33018 AAA29004   M33019 AAA29005   M33121 AAA29006   M33122 AAA29007   M37604   M37605 AAA28821   M37606 AAA28822   M37607 AAA28823   M37608 AAA28824   M37609 AAA28825   M37610 AAA28826
UniProtKB/Swiss-Prot	P0CG69
UniProtKB/TrEMBL	A4V1F9 Q8MSM5 Q7JPZ3 Q99350 Q99347 Q24575 Q99351 Q7JPZ2 Q99348 Q27927 Q24576 Q24577 Q99349
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage & larval stage & pupal stage     (Lee et al., 1988) embryonic stage -- adult stage     (Lee et al., 1988)
Additional Descriptive Data
	Ubi-p63E transcripts are observed in all stages assayed. A reporter construct was used to show that they are expressed in a tissue-general pattern in all life stages assayed. (Lee et al., 1988)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
microtubule associated complex inferred from direct assay (Hughes et al., 2008)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    1480.55 Larval Midgut    3144.3 Larval Hindgut    2308.1 Larval Malpighian Tubules    2767.6 Larval Fat Body    2669.2 Larval Salivary Gland    2380.6 Larval Trachea    1425.675 Larval Carcass    1907.225 Adult Head    1774.7 Adult Eye    2596.325 Adult Brain    1479.1 Adult Thoracic-Abdominal Ganglion    1722.6 Adult Crop    2901.8 Adult Midgut    1935.4 Adult Hindgut    1865.3 Adult Malpighian Tubules    2292.9 Adult Fat Body    2693.7 Adult Salivary Gland    1860.5 Adult Heart    2919.175 Adult VirginFemale Spermatheca    1866.1 Adult InseminatedFemale Spermatheca    1856.6 Adult Ovary    1613.7 Adult Testis    3628 Adult Male Accessory Gland    2919.8 Adult Carcass    2406.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1480.55) Larval Midgut  (3144.3) Larval Hindgut  (2308.1) Larval Malpighian Tubules  (2767.6) Larval Fat Body  (2669.2) Larval Salivary Gland  (2380.6) Larval Trachea  (1425.675) Larval Carcass  (1907.225) Adult Head  (1774.7) Adult Eye  (2596.325) Adult Brain  (1479.1) Adult Thoracic-Abdominal Ganglion  (1722.6) Adult Crop  (2901.8) Adult Midgut  (1935.4) Adult Hindgut  (1865.3) Adult Malpighian Tubules  (2292.9) Adult Fat Body  (2693.7) Adult Salivary Gland  (1860.5) Adult Heart  (2919.175) Adult VirginFemale Spermatheca  (1866.1) Adult InseminatedFemale Spermatheca  (1856.6) Adult Ovary  (1613.7) Adult Testis  (3628) Adult Male Accessory Gland  (2919.8) Adult Carcass  (2406.4) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (1480.55) Larval Midgut  (3144.3) Larval Hindgut  (2308.1) Larval Malpighian Tubules  (2767.6) Larval Fat Body  (2669.2) Larval Salivary Gland  (2380.6) Larval Trachea  (1425.675) Larval Carcass  (1907.225) Adult Head  (1774.7) Adult Eye  (2596.325) Adult Brain  (1479.1) Adult Thoracic-Abdominal Ganglion  (1722.6) Adult Crop  (2901.8) Adult Midgut  (1935.4) Adult Hindgut  (1865.3) Adult Malpighian Tubules  (2292.9) Adult Fat Body  (2693.7) Adult Salivary Gland  (1860.5) Adult Heart  (2919.175) Adult VirginFemale Spermatheca  (1866.1) Adult InseminatedFemale Spermatheca  (1856.6) Adult Ovary  (1613.7) Adult Testis  (3628) Adult Male Accessory Gland  (2919.8) Adult Carcass  (2406.4) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1480.55 Larval Midgut    3144.3 Larval Hindgut    2308.1 Larval Malpighian Tubules    2767.6 Larval Fat Body    2669.2 Larval Salivary Gland    2380.6 Larval Trachea    1425.675 Larval Carcass    1907.225 Adult Head    1774.7 Adult Eye    2596.325 Adult Brain    1479.1 Adult Thoracic-Abdominal Ganglion    1722.6 Adult Crop    2901.8 Adult Midgut    1935.4 Adult Hindgut    1865.3 Adult Malpighian Tubules    2292.9 Adult Fat Body    2693.7 Adult Salivary Gland    1860.5 Adult Heart    2919.175 Adult VirginFemale Spermatheca    1866.1 Adult InseminatedFemale Spermatheca    1856.6 Adult Ovary    1613.7 Adult Testis    3628 Adult Male Accessory Gland    2919.8 Adult Carcass    2406.4 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    1480.55 Larval Midgut    3144.3 Larval Hindgut    2308.1 Larval Malpighian Tubules    2767.6 Larval Fat Body    2669.2 Larval Salivary Gland    2380.6 Larval Trachea    1425.675 Larval Carcass    1907.225 Adult Head    1774.7 Adult Eye    2596.325 Adult Brain    1479.1 Adult Thoracic-Abdominal Ganglion    1722.6 Adult Crop    2901.8 Adult Midgut    1935.4 Adult Hindgut    1865.3 Adult Malpighian Tubules    2292.9 Adult Fat Body    2693.7 Adult Salivary Gland    1860.5 Adult Heart    2919.175 Adult VirginFemale Spermatheca    1866.1 Adult InseminatedFemale Spermatheca    1856.6 Adult Ovary    1613.7 Adult Testis    3628 Adult Male Accessory Gland    2919.8 Adult Carcass    2406.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1480.55) Larval Midgut  (3144.3) Larval Hindgut  (2308.1) Larval Malpighian Tubules  (2767.6) Larval Fat Body  (2669.2) Larval Salivary Gland  (2380.6) Larval Trachea  (1425.675) Larval Carcass  (1907.225) Adult Head  (1774.7) Adult Eye  (2596.325) Adult Brain  (1479.1) Adult Thoracic-Abdominal Ganglion  (1722.6) Adult Crop  (2901.8) Adult Midgut  (1935.4) Adult Hindgut  (1865.3) Adult Malpighian Tubules  (2292.9) Adult Fat Body  (2693.7) Adult Salivary Gland  (1860.5) Adult Heart  (2919.175) Adult VirginFemale Spermatheca  (1866.1) Adult InseminatedFemale Spermatheca  (1856.6) Adult Ovary  (1613.7) Adult Testis  (3628) Adult Male Accessory Gland  (2919.8) Adult Carcass  (2406.4) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  1480.55 Larval Midgut  (3144.3) Larval Hindgut  (2308.1) Larval Malpighian Tubules  (2767.6) Larval Fat Body  (2669.2) Larval Salivary Gland  (2380.6) Larval Trachea  1425.675 Larval Carcass  (1907.225) Adult Head  (1774.7) Adult Eye  (2596.325) Adult Brain  1479.1 Adult Thoracic-Abdominal Ganglion  (1722.6) Adult Crop  (2901.8) Adult Midgut  (1935.4) Adult Hindgut  (1865.3) Adult Malpighian Tubules  (2292.9) Adult Fat Body  (2693.7) Adult Salivary Gland  (1860.5) Adult Heart  (2919.175) Adult VirginFemale Spermatheca  (1866.1) Adult InseminatedFemale Spermatheca  (1856.6) Adult Ovary  1613.7 Adult Testis  (3628) Adult Male Accessory Gland  (2919.8) Adult Carcass  (2406.4) Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1480.55 Larval Midgut    3144.3 Larval Hindgut    2308.1 Larval Malpighian Tubules    2767.6 Larval Fat Body    2669.2 Larval Salivary Gland    2380.6 Larval Trachea    1425.675 Larval Carcass    1907.225 Adult Head    1774.7 Adult Eye    2596.325 Adult Brain    1479.1 Adult Thoracic-Abdominal Ganglion    1722.6 Adult Crop    2901.8 Adult Midgut    1935.4 Adult Hindgut    1865.3 Adult Malpighian Tubules    2292.9 Adult Fat Body    2693.7 Adult Salivary Gland    1860.5 Adult Heart    2919.175 Adult VirginFemale Spermatheca    1866.1 Adult InseminatedFemale Spermatheca    1856.6 Adult Ovary    1613.7 Adult Testis    3628 Adult Male Accessory Gland    2919.8 Adult Carcass    2406.4 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    1774.7   NA  Eye    2596.325   NA  Brain    1479.1   1480.55  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    1722.6   NA  Crop    2901.8   3144.3  Midgut    1935.4   2308.1  Hindgut    1865.3   2767.6  Malpighian Tubules    2292.9   2669.2  Fat Body    2693.7   2380.6  Salivary Gland    1860.5   NA  Heart    2919.175   1425.675  Trachea    NA   NA  VirginFemale Spermatheca    1866.1   NA  InseminatedFemale Spermatheca    1856.6   NA  Ovary    1613.7   NA  Testis    3628   NA  Male Accessory Gland    2919.8   1907.225  Carcass    2406.4 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    532 central nervous system, larvae L3    189 central nervous system, pupae P8    122 head, virgin 1-day female    144 head, virgin 4-day female    123 head, virgin 20-day female    195 head, mated 1-day female    114 head, mated 4-day female    97 head, mated 20-day female    152 head, mated 1-day male    213 head, mated 4-day male    148 head, mated 20-day male    181 salivary gland, larvae L3 wandering    99 salivary gland, white prepupae    410 digestive system, larvae L3 wandering    352 digestive system, 1-day adult    165 digestive system, 4-day adult    166 digestive system, 20-day adult    180 fat body, larvae L3 wandering    104 fat body, white prepupae    238 fat body, pupae P8    276 carcass, larvae L3 wandering    348 carcass, 1-day adult    225 carcass, 4-day adult    162 carcass, 20-day adult    217 ovary, virgin 4-day female    265 ovary, mated 4-day female    202 testis, mated 4-day male    1732 accessory gland, mated 4-day male    325 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (532) central nervous system, larvae L3  (189) central nervous system, pupae P8  (122) head, virgin 1-day female  (144) head, virgin 4-day female  (123) head, virgin 20-day female  (195) head, mated 1-day female  (114) head, mated 4-day female  (97) head, mated 20-day female  (152) head, mated 1-day male  (213) head, mated 4-day male  (148) head, mated 20-day male  (181) salivary gland, larvae L3 wandering  (99) salivary gland, white prepupae  (410) digestive system, larvae L3 wandering  (352) digestive system, 1-day adult  (165) digestive system, 4-day adult  (166) digestive system, 20-day adult  (180) fat body, larvae L3 wandering  (104) fat body, white prepupae  (238) fat body, pupae P8  (276) carcass, larvae L3 wandering  (348) carcass, 1-day adult  (225) carcass, 4-day adult  (162) carcass, 20-day adult  (217) ovary, virgin 4-day female  (265) ovary, mated 4-day female  (202) testis, mated 4-day male  (1732) accessory gland, mated 4-day male  (325) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (532) central nervous system, larvae L3  (189) central nervous system, pupae P8  (122) head, virgin 1-day female  (144) head, virgin 4-day female  (123) head, virgin 20-day female  (195) head, mated 1-day female  (114) head, mated 4-day female    97 head, mated 20-day female  (152) head, mated 1-day male  (213) head, mated 4-day male  (148) head, mated 20-day male  (181) salivary gland, larvae L3 wandering    99 salivary gland, white prepupae  (410) digestive system, larvae L3 wandering  (352) digestive system, 1-day adult  (165) digestive system, 4-day adult  (166) digestive system, 20-day adult  (180) fat body, larvae L3 wandering  104 fat body, white prepupae  (238) fat body, pupae P8  (276) carcass, larvae L3 wandering  (348) carcass, 1-day adult  (225) carcass, 4-day adult  (162) carcass, 20-day adult  (217) ovary, virgin 4-day female  (265) ovary, mated 4-day female  (202) testis, mated 4-day male  (1732) accessory gland, mated 4-day male  (325) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    532 central nervous system, larvae L3    189 central nervous system, pupae P8    122 head, virgin 1-day female    144 head, virgin 4-day female    123 head, virgin 20-day female    195 head, mated 1-day female    114 head, mated 4-day female    97 head, mated 20-day female    152 head, mated 1-day male    213 head, mated 4-day male    148 head, mated 20-day male    181 salivary gland, larvae L3 wandering    99 salivary gland, white prepupae    410 digestive system, larvae L3 wandering    352 digestive system, 1-day adult    165 digestive system, 4-day adult    166 digestive system, 20-day adult    180 fat body, larvae L3 wandering    104 fat body, white prepupae    238 fat body, pupae P8    276 carcass, larvae L3 wandering    348 carcass, 1-day adult    225 carcass, 4-day adult    162 carcass, 20-day adult    217 ovary, virgin 4-day female    265 ovary, mated 4-day female    202 testis, mated 4-day male    1732 accessory gland, mated 4-day male    325 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    532 central nervous system, larvae L3    189 central nervous system, pupae P8    122 head, virgin 1-day female    144 head, virgin 4-day female    123 head, virgin 20-day female    195 head, mated 1-day female    114 head, mated 4-day female    97 head, mated 20-day female    152 head, mated 1-day male    213 head, mated 4-day male    148 head, mated 20-day male    181 salivary gland, larvae L3 wandering    99 salivary gland, white prepupae    410 digestive system, larvae L3 wandering    352 digestive system, 1-day adult    165 digestive system, 4-day adult    166 digestive system, 20-day adult    180 fat body, larvae L3 wandering    104 fat body, white prepupae    238 fat body, pupae P8    276 carcass, larvae L3 wandering    348 carcass, 1-day adult    225 carcass, 4-day adult    162 carcass, 20-day adult    217 ovary, virgin 4-day female    265 ovary, mated 4-day female    202 testis, mated 4-day male    1732 accessory gland, mated 4-day male    325 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (532) central nervous system, larvae L3  (189) central nervous system, pupae P8  (122) head, virgin 1-day female  (144) head, virgin 4-day female  (123) head, virgin 20-day female  (195) head, mated 1-day female  (114) head, mated 4-day female  (97) head, mated 20-day female  (152) head, mated 1-day male  (213) head, mated 4-day male  (148) head, mated 20-day male  (181) salivary gland, larvae L3 wandering  (99) salivary gland, white prepupae  (410) digestive system, larvae L3 wandering  (352) digestive system, 1-day adult  (165) digestive system, 4-day adult  (166) digestive system, 20-day adult  (180) fat body, larvae L3 wandering  (104) fat body, white prepupae  (238) fat body, pupae P8  (276) carcass, larvae L3 wandering  (348) carcass, 1-day adult  (225) carcass, 4-day adult  (162) carcass, 20-day adult  (217) ovary, virgin 4-day female  (265) ovary, mated 4-day female  (202) testis, mated 4-day male  (1732) accessory gland, mated 4-day male  (325) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (532) central nervous system, larvae L3  (189) central nervous system, pupae P8  122 head, virgin 1-day female  (144) head, virgin 4-day female  123 head, virgin 20-day female  (195) head, mated 1-day female  114 head, mated 4-day female    97 head, mated 20-day female  (152) head, mated 1-day male  (213) head, mated 4-day male  (148) head, mated 20-day male  (181) salivary gland, larvae L3 wandering    99 salivary gland, white prepupae  (410) digestive system, larvae L3 wandering  (352) digestive system, 1-day adult  (165) digestive system, 4-day adult  (166) digestive system, 20-day adult  (180) fat body, larvae L3 wandering  104 fat body, white prepupae  (238) fat body, pupae P8  (276) carcass, larvae L3 wandering  (348) carcass, 1-day adult  (225) carcass, 4-day adult  (162) carcass, 20-day adult  (217) ovary, virgin 4-day female  (265) ovary, mated 4-day female  (202) testis, mated 4-day male  (1732) accessory gland, mated 4-day male  (325) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    532 central nervous system, larvae L3    189 central nervous system, pupae P8    122 head, virgin 1-day female    144 head, virgin 4-day female    123 head, virgin 20-day female    195 head, mated 1-day female    114 head, mated 4-day female    97 head, mated 20-day female    152 head, mated 1-day male    213 head, mated 4-day male    148 head, mated 20-day male    181 salivary gland, larvae L3 wandering    99 salivary gland, white prepupae    410 digestive system, larvae L3 wandering    352 digestive system, 1-day adult    165 digestive system, 4-day adult    166 digestive system, 20-day adult    180 fat body, larvae L3 wandering    104 fat body, white prepupae    238 fat body, pupae P8    276 carcass, larvae L3 wandering    348 carcass, 1-day adult    225 carcass, 4-day adult    162 carcass, 20-day adult    217 ovary, virgin 4-day female    265 ovary, mated 4-day female    202 testis, mated 4-day male    1732 accessory gland, mated 4-day male    325 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 06-18 hour embryonic stages, during late larval stages, at stages throughout the pupal period, in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    15 embryo 02-04hr    7 embryo 04-06hr    16 embryo 06-08hr    35 embryo 08-10hr    35 embryo 10-12hr    37 embryo 12-14hr    30 embryo 14-16hr    15 embryo 16-18hr    18 embryo 18-20hr    10 embryo 20-22hr    6 embryo 22-24hr    11 larva L1    4 larva L2    8 larva L3 12hr old    6 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    28 white prepupae new    39 white prepupae 12hr    50 white prepupae 24hr    38 pupae 2d postWPP    27 pupae 3d postWPP    28 pupae 4d postWPP    20 adult male 01day    43 adult male 05day    46 adult male 30day    30 adult female 01day    10 adult female 05day    16 adult female 30day    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    15 embryo 02-04hr    7 embryo 04-06hr    16 embryo 06-08hr  (35) embryo 08-10hr  (35) embryo 10-12hr  (37) embryo 12-14hr  (30) embryo 14-16hr    15 embryo 16-18hr    18 embryo 18-20hr    10 embryo 20-22hr    6 embryo 22-24hr    11 larva L1    4 larva L2    8 larva L3 12hr old    6 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9  (28) white prepupae new  (39) white prepupae 12hr  (50) white prepupae 24hr  (38) pupae 2d postWPP  (27) pupae 3d postWPP  (28) pupae 4d postWPP    20 adult male 01day  (43) adult male 05day  (46) adult male 30day  (30) adult female 01day    10 adult female 05day    16 adult female 30day    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    15 embryo 02-04hr    7 embryo 04-06hr    16 embryo 06-08hr    35 embryo 08-10hr    35 embryo 10-12hr    37 embryo 12-14hr    30 embryo 14-16hr    15 embryo 16-18hr    18 embryo 18-20hr    10 embryo 20-22hr    6 embryo 22-24hr    11 larva L1    4 larva L2    8 larva L3 12hr old    6 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    28 white prepupae new    39 white prepupae 12hr    50 white prepupae 24hr    38 pupae 2d postWPP    27 pupae 3d postWPP    28 pupae 4d postWPP    20 adult male 01day    43 adult male 05day    46 adult male 30day    30 adult female 01day    10 adult female 05day    16 adult female 30day    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    15 embryo 02-04hr    7 embryo 04-06hr    16 embryo 06-08hr    35 embryo 08-10hr    35 embryo 10-12hr    37 embryo 12-14hr    30 embryo 14-16hr    15 embryo 16-18hr    18 embryo 18-20hr    10 embryo 20-22hr    6 embryo 22-24hr    11 larva L1    4 larva L2    8 larva L3 12hr old    6 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    28 white prepupae new    39 white prepupae 12hr    50 white prepupae 24hr    38 pupae 2d postWPP    27 pupae 3d postWPP    28 pupae 4d postWPP    20 adult male 01day    43 adult male 05day    46 adult male 30day    30 adult female 01day    10 adult female 05day    16 adult female 30day    14 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    15 embryo 02-04hr    7 embryo 04-06hr    16 embryo 06-08hr    35 embryo 08-10hr    35 embryo 10-12hr    37 embryo 12-14hr    30 embryo 14-16hr    15 embryo 16-18hr    18 embryo 18-20hr    10 embryo 20-22hr    6 embryo 22-24hr    11 larva L1    4 larva L2    8 larva L3 12hr old    6 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    28 white prepupae new    39 white prepupae 12hr    50 white prepupae 24hr    38 pupae 2d postWPP    27 pupae 3d postWPP    28 pupae 4d postWPP    20 adult male 01day    43 adult male 05day    46 adult male 30day    30 adult female 01day    10 adult female 05day    16 adult female 30day    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    15 embryo 02-04hr    7 embryo 04-06hr    16 embryo 06-08hr  (35) embryo 08-10hr  (35) embryo 10-12hr  (37) embryo 12-14hr  30 embryo 14-16hr    15 embryo 16-18hr    18 embryo 18-20hr    10 embryo 20-22hr    6 embryo 22-24hr    11 larva L1    4 larva L2    8 larva L3 12hr old    6 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9  28 white prepupae new  (39) white prepupae 12hr  (50) white prepupae 24hr  (38) pupae 2d postWPP  27 pupae 3d postWPP  28 pupae 4d postWPP    20 adult male 01day  (43) adult male 05day  (46) adult male 30day  30 adult female 01day    10 adult female 05day    16 adult female 30day    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    15 embryo 02-04hr    7 embryo 04-06hr    16 embryo 06-08hr    35 embryo 08-10hr    35 embryo 10-12hr    37 embryo 12-14hr    30 embryo 14-16hr    15 embryo 16-18hr    18 embryo 18-20hr    10 embryo 20-22hr    6 embryo 22-24hr    11 larva L1    4 larva L2    8 larva L3 12hr old    6 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    28 white prepupae new    39 white prepupae 12hr    50 white prepupae 24hr    38 pupae 2d postWPP    27 pupae 3d postWPP    28 pupae 4d postWPP    20 adult male 01day    43 adult male 05day    46 adult male 30day    30 adult female 01day    10 adult female 05day    16 adult female 30day    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    15 embryo 02-04hr    7 embryo 04-06hr    16 embryo 06-08hr    35 embryo 08-10hr    35 embryo 10-12hr    37 embryo 12-14hr    30 embryo 14-16hr    15 embryo 16-18hr    18 embryo 18-20hr    10 embryo 20-22hr    6 embryo 22-24hr    11 larva L1    4 larva L2    8 larva L3 12hr old    6 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    28 white prepupae new    39 white prepupae 12hr    50 white prepupae 24hr    38 pupae 2d postWPP    27 pupae 3d postWPP    28 pupae 4d postWPP    20 adult male 01day    43 adult male 05day    46 adult male 30day    30 adult female 01day    10 adult female 05day    16 adult female 30day    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    203 Schneider line 2 Sg4    449 embryonic 1182-4H    214 embryonic GM2    244 embryonic Kc167    300 embryonic S1    467 embryonic S3    260 leg disc CME L1    302 wing disc CME-W2    258 wing disc ML-DmD8    194 wing disc ML-DmD9    289 wing disc ML-DmD16-c3    142 wing disc ML-DmD21    379 wing disc ML-DmD32    195 haltere disc ML-DmD17-c3    283 eye-antennal disc ML-DmD11    231 antennal disc ML-DmD20-c5    186 mixed discs ML-DmD4-c1    271 CNS ML-DmBG1-c1    211 CNS ML-DmBG2-c2    289 tumorous blood cells mbn2    269 ovary fGS/OSS    429 ovary OSC    298 ovary OSS    143 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (203) Schneider line 2 Sg4  (449) embryonic 1182-4H  (214) embryonic GM2  (244) embryonic Kc167  (300) embryonic S1  (467) embryonic S3  (260) leg disc CME L1  (302) wing disc CME-W2  (258) wing disc ML-DmD8  (194) wing disc ML-DmD9  (289) wing disc ML-DmD16-c3  (142) wing disc ML-DmD21  (379) wing disc ML-DmD32  (195) haltere disc ML-DmD17-c3  (283) eye-antennal disc ML-DmD11  (231) antennal disc ML-DmD20-c5  (186) mixed discs ML-DmD4-c1  (271) CNS ML-DmBG1-c1  (211) CNS ML-DmBG2-c2  (289) tumorous blood cells mbn2  (269) ovary fGS/OSS  (429) ovary OSC  (298) ovary OSS  (143) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (203) Schneider line 2 Sg4  (449) embryonic 1182-4H  (214) embryonic GM2  (244) embryonic Kc167  (300) embryonic S1  (467) embryonic S3  (260) leg disc CME L1  (302) wing disc CME-W2  (258) wing disc ML-DmD8  (194) wing disc ML-DmD9  (289) wing disc ML-DmD16-c3  (142) wing disc ML-DmD21  (379) wing disc ML-DmD32  (195) haltere disc ML-DmD17-c3  (283) eye-antennal disc ML-DmD11  (231) antennal disc ML-DmD20-c5  (186) mixed discs ML-DmD4-c1  (271) CNS ML-DmBG1-c1  (211) CNS ML-DmBG2-c2  (289) tumorous blood cells mbn2  (269) ovary fGS/OSS  (429) ovary OSC  (298) ovary OSS  (143) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    203 Schneider line 2 Sg4    449 embryonic 1182-4H    214 embryonic GM2    244 embryonic Kc167    300 embryonic S1    467 embryonic S3    260 leg disc CME L1    302 wing disc CME-W2    258 wing disc ML-DmD8    194 wing disc ML-DmD9    289 wing disc ML-DmD16-c3    142 wing disc ML-DmD21    379 wing disc ML-DmD32    195 haltere disc ML-DmD17-c3    283 eye-antennal disc ML-DmD11    231 antennal disc ML-DmD20-c5    186 mixed discs ML-DmD4-c1    271 CNS ML-DmBG1-c1    211 CNS ML-DmBG2-c2    289 tumorous blood cells mbn2    269 ovary fGS/OSS    429 ovary OSC    298 ovary OSS    143 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    203 Schneider line 2 Sg4    449 embryonic 1182-4H    214 embryonic GM2    244 embryonic Kc167    300 embryonic S1    467 embryonic S3    260 leg disc CME L1    302 wing disc CME-W2    258 wing disc ML-DmD8    194 wing disc ML-DmD9    289 wing disc ML-DmD16-c3    142 wing disc ML-DmD21    379 wing disc ML-DmD32    195 haltere disc ML-DmD17-c3    283 eye-antennal disc ML-DmD11    231 antennal disc ML-DmD20-c5    186 mixed discs ML-DmD4-c1    271 CNS ML-DmBG1-c1    211 CNS ML-DmBG2-c2    289 tumorous blood cells mbn2    269 ovary fGS/OSS    429 ovary OSC    298 ovary OSS    143 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (203) Schneider line 2 Sg4  (449) embryonic 1182-4H  (214) embryonic GM2  (244) embryonic Kc167  (300) embryonic S1  (467) embryonic S3  (260) leg disc CME L1  (302) wing disc CME-W2  (258) wing disc ML-DmD8  (194) wing disc ML-DmD9  (289) wing disc ML-DmD16-c3  (142) wing disc ML-DmD21  (379) wing disc ML-DmD32  (195) haltere disc ML-DmD17-c3  (283) eye-antennal disc ML-DmD11  (231) antennal disc ML-DmD20-c5  (186) mixed discs ML-DmD4-c1  (271) CNS ML-DmBG1-c1  (211) CNS ML-DmBG2-c2  (289) tumorous blood cells mbn2  (269) ovary fGS/OSS  (429) ovary OSC  (298) ovary OSS  (143) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (203) Schneider line 2 Sg4  (449) embryonic 1182-4H  (214) embryonic GM2  (244) embryonic Kc167  (300) embryonic S1  (467) embryonic S3  (260) leg disc CME L1  (302) wing disc CME-W2  (258) wing disc ML-DmD8  (194) wing disc ML-DmD9  (289) wing disc ML-DmD16-c3  142 wing disc ML-DmD21  (379) wing disc ML-DmD32  (195) haltere disc ML-DmD17-c3  (283) eye-antennal disc ML-DmD11  (231) antennal disc ML-DmD20-c5  (186) mixed discs ML-DmD4-c1  (271) CNS ML-DmBG1-c1  (211) CNS ML-DmBG2-c2  (289) tumorous blood cells mbn2  (269) ovary fGS/OSS  (429) ovary OSC  (298) ovary OSS  143 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    203 Schneider line 2 Sg4    449 embryonic 1182-4H    214 embryonic GM2    244 embryonic Kc167    300 embryonic S1    467 embryonic S3    260 leg disc CME L1    302 wing disc CME-W2    258 wing disc ML-DmD8    194 wing disc ML-DmD9    289 wing disc ML-DmD16-c3    142 wing disc ML-DmD21    379 wing disc ML-DmD32    195 haltere disc ML-DmD17-c3    283 eye-antennal disc ML-DmD11    231 antennal disc ML-DmD20-c5    186 mixed discs ML-DmD4-c1    271 CNS ML-DmBG1-c1    211 CNS ML-DmBG2-c2    289 tumorous blood cells mbn2    269 ovary fGS/OSS    429 ovary OSC    298 ovary OSS    143 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    177 cold shock, 4-day adult    169 heat shock, 4-day adult    272 Cadmium 50 mM 6 hrs, larvae L3    151 Cadmium 50 mM 12 hrs, larvae L3    103 Cadmium 50 mM 48 hrs, 4-day adult    220 Cadmium 100 mM 48 hrs, 4-day adult    402 Copper 0.5 mM 12 hrs, larvae L3    112 Copper 15 mM 48 hrs, 4-day adult    79 Zinc 5 mM 12 hrs, larvae L3    90 Zinc 4.5 mM 48 hrs, 4-day adult    237 Ethanol 2.5% 3 hrs, larvae L3    538 Ethanol 5% 3 hrs, larvae L3    142 Ethanol 10% 3 hrs, larvae L3    137 Caffeine 1.5 mg/ml 4 hrs, larvae L3    130 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    217 Caffeine 25 mg/ml 48 hrs, 4-day adult    136 Paraquat 5 mM 48 hrs, 4-day adult    312 Paraquat 10 mM 48 hrs, 4-day adult    589 Rotenone 2 μg 12 hrs, larvae L3    165 Rotenone 8 μg 12 hrs, larvae L3    126 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (177) cold shock, 4-day adult  (169) heat shock, 4-day adult  (272) Cadmium 50 mM 6 hrs, larvae L3  (151) Cadmium 50 mM 12 hrs, larvae L3  (103) Cadmium 50 mM 48 hrs, 4-day adult  (220) Cadmium 100 mM 48 hrs, 4-day adult  (402) Copper 0.5 mM 12 hrs, larvae L3  (112) Copper 15 mM 48 hrs, 4-day adult  (79) Zinc 5 mM 12 hrs, larvae L3  (90) Zinc 4.5 mM 48 hrs, 4-day adult  (237) Ethanol 2.5% 3 hrs, larvae L3  (538) Ethanol 5% 3 hrs, larvae L3  (142) Ethanol 10% 3 hrs, larvae L3  (137) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (130) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (217) Caffeine 25 mg/ml 48 hrs, 4-day adult  (136) Paraquat 5 mM 48 hrs, 4-day adult  (312) Paraquat 10 mM 48 hrs, 4-day adult  (589) Rotenone 2 μg 12 hrs, larvae L3  (165) Rotenone 8 μg 12 hrs, larvae L3  (126) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult  (177) cold shock, 4-day adult  (169) heat shock, 4-day adult  (272) Cadmium 50 mM 6 hrs, larvae L3  (151) Cadmium 50 mM 12 hrs, larvae L3  103 Cadmium 50 mM 48 hrs, 4-day adult  (220) Cadmium 100 mM 48 hrs, 4-day adult  (402) Copper 0.5 mM 12 hrs, larvae L3  (112) Copper 15 mM 48 hrs, 4-day adult    79 Zinc 5 mM 12 hrs, larvae L3    90 Zinc 4.5 mM 48 hrs, 4-day adult  (237) Ethanol 2.5% 3 hrs, larvae L3  (538) Ethanol 5% 3 hrs, larvae L3  (142) Ethanol 10% 3 hrs, larvae L3  (137) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (130) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (217) Caffeine 25 mg/ml 48 hrs, 4-day adult  (136) Paraquat 5 mM 48 hrs, 4-day adult  (312) Paraquat 10 mM 48 hrs, 4-day adult  (589) Rotenone 2 μg 12 hrs, larvae L3  (165) Rotenone 8 μg 12 hrs, larvae L3  (126) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    177 cold shock, 4-day adult    169 heat shock, 4-day adult    272 Cadmium 50 mM 6 hrs, larvae L3    151 Cadmium 50 mM 12 hrs, larvae L3    103 Cadmium 50 mM 48 hrs, 4-day adult    220 Cadmium 100 mM 48 hrs, 4-day adult    402 Copper 0.5 mM 12 hrs, larvae L3    112 Copper 15 mM 48 hrs, 4-day adult    79 Zinc 5 mM 12 hrs, larvae L3    90 Zinc 4.5 mM 48 hrs, 4-day adult    237 Ethanol 2.5% 3 hrs, larvae L3    538 Ethanol 5% 3 hrs, larvae L3    142 Ethanol 10% 3 hrs, larvae L3    137 Caffeine 1.5 mg/ml 4 hrs, larvae L3    130 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    217 Caffeine 25 mg/ml 48 hrs, 4-day adult    136 Paraquat 5 mM 48 hrs, 4-day adult    312 Paraquat 10 mM 48 hrs, 4-day adult    589 Rotenone 2 μg 12 hrs, larvae L3    165 Rotenone 8 μg 12 hrs, larvae L3    126 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    177 cold shock, 4-day adult    169 heat shock, 4-day adult    272 Cadmium 50 mM 6 hrs, larvae L3    151 Cadmium 50 mM 12 hrs, larvae L3    103 Cadmium 50 mM 48 hrs, 4-day adult    220 Cadmium 100 mM 48 hrs, 4-day adult    402 Copper 0.5 mM 12 hrs, larvae L3    112 Copper 15 mM 48 hrs, 4-day adult    79 Zinc 5 mM 12 hrs, larvae L3    90 Zinc 4.5 mM 48 hrs, 4-day adult    237 Ethanol 2.5% 3 hrs, larvae L3    538 Ethanol 5% 3 hrs, larvae L3    142 Ethanol 10% 3 hrs, larvae L3    137 Caffeine 1.5 mg/ml 4 hrs, larvae L3    130 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    217 Caffeine 25 mg/ml 48 hrs, 4-day adult    136 Paraquat 5 mM 48 hrs, 4-day adult    312 Paraquat 10 mM 48 hrs, 4-day adult    589 Rotenone 2 μg 12 hrs, larvae L3    165 Rotenone 8 μg 12 hrs, larvae L3    126 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (177) cold shock, 4-day adult  (169) heat shock, 4-day adult  (272) Cadmium 50 mM 6 hrs, larvae L3  (151) Cadmium 50 mM 12 hrs, larvae L3  (103) Cadmium 50 mM 48 hrs, 4-day adult  (220) Cadmium 100 mM 48 hrs, 4-day adult  (402) Copper 0.5 mM 12 hrs, larvae L3  (112) Copper 15 mM 48 hrs, 4-day adult  (79) Zinc 5 mM 12 hrs, larvae L3  (90) Zinc 4.5 mM 48 hrs, 4-day adult  (237) Ethanol 2.5% 3 hrs, larvae L3  (538) Ethanol 5% 3 hrs, larvae L3  (142) Ethanol 10% 3 hrs, larvae L3  (137) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (130) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (217) Caffeine 25 mg/ml 48 hrs, 4-day adult  (136) Paraquat 5 mM 48 hrs, 4-day adult  (312) Paraquat 10 mM 48 hrs, 4-day adult  (589) Rotenone 2 μg 12 hrs, larvae L3  (165) Rotenone 8 μg 12 hrs, larvae L3  (126) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult  (177) cold shock, 4-day adult  (169) heat shock, 4-day adult  (272) Cadmium 50 mM 6 hrs, larvae L3  (151) Cadmium 50 mM 12 hrs, larvae L3  103 Cadmium 50 mM 48 hrs, 4-day adult  (220) Cadmium 100 mM 48 hrs, 4-day adult  (402) Copper 0.5 mM 12 hrs, larvae L3  112 Copper 15 mM 48 hrs, 4-day adult    79 Zinc 5 mM 12 hrs, larvae L3    90 Zinc 4.5 mM 48 hrs, 4-day adult  (237) Ethanol 2.5% 3 hrs, larvae L3  (538) Ethanol 5% 3 hrs, larvae L3  142 Ethanol 10% 3 hrs, larvae L3  137 Caffeine 1.5 mg/ml 4 hrs, larvae L3  130 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (217) Caffeine 25 mg/ml 48 hrs, 4-day adult  136 Paraquat 5 mM 48 hrs, 4-day adult  (312) Paraquat 10 mM 48 hrs, 4-day adult  (589) Rotenone 2 μg 12 hrs, larvae L3  (165) Rotenone 8 μg 12 hrs, larvae L3  126 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    177 cold shock, 4-day adult    169 heat shock, 4-day adult    272 Cadmium 50 mM 6 hrs, larvae L3    151 Cadmium 50 mM 12 hrs, larvae L3    103 Cadmium 50 mM 48 hrs, 4-day adult    220 Cadmium 100 mM 48 hrs, 4-day adult    402 Copper 0.5 mM 12 hrs, larvae L3    112 Copper 15 mM 48 hrs, 4-day adult    79 Zinc 5 mM 12 hrs, larvae L3    90 Zinc 4.5 mM 48 hrs, 4-day adult    237 Ethanol 2.5% 3 hrs, larvae L3    538 Ethanol 5% 3 hrs, larvae L3    142 Ethanol 10% 3 hrs, larvae L3    137 Caffeine 1.5 mg/ml 4 hrs, larvae L3    130 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    217 Caffeine 25 mg/ml 48 hrs, 4-day adult    136 Paraquat 5 mM 48 hrs, 4-day adult    312 Paraquat 10 mM 48 hrs, 4-day adult    589 Rotenone 2 μg 12 hrs, larvae L3    165 Rotenone 8 μg 12 hrs, larvae L3    126 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_21 mE1_20_mRNA_expression_cluster_09
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003943 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11624-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable Ubi-p63EEY07341 Sterility Allele fertile Ubi-p63EEY07341 Other Phenotypes Allele increased cell death Ubi-p63EdsRNA.cRa Phenotype manifest in Allele
Classical Alleles ( 5 )
For All Classical Alleles Show
Allele of Ubi-p63E Class Mutagen Stocks Known lesion Ubi-p63Ec04861 piggyBac transposase 1 -- Ubi-p63Ee02712 piggyBac transposase 1 -- Ubi-p63EEY07341 P-element activity 1 -- Ubi-p63Ee03111 piggyBac transposase 0 -- Ubi-p63Eunspecified 0 --
Alleles Carried on Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Ubi-p63E Class Mutagen Stocks Known lesion Ubi-p63EHMS00284 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Ubi-p63EKK109327 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Ubi-p63EdsRNA.cMa in vitro construct - RNAi 0 -- Ubi-p63EdsRNA.cRa in vitro construct - RNAi 0 Yes Ubi-p63Ehs.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Ubi-p63EMtnA.T:Ivir\HA1 in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)Exel6098 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data reporter construct P{FRT(nlacZ,α-spectrin)} No P{Ubi-GFP.S65T} No P{Ubi-GFP(S65T)nls} No vital-reporter construct P{Ubi-GFP(S65T)nls} No UAS construct P{GD9867} NA P{KK109327} NA P{TRiP.HMS00284} NA characterization construct P{mammal\Sek1Ubi-p63E.PH} NA P{Mmus\Mkk7Ubi-p63E.PH} NA P{Ubi-GFP.D} NA P{Ubi-GFP.nls} NA P{Xlae\Mek2Ubi-p63E.PH} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{PZ}Sc205634 No insertion of mobile activating element P{EPgy2}Ubi-p63EEY07341 NA miscellaneous insertions P{UASp-YFP.Rab8.Q67L}Sc210 NA PBac{PB}Ubi-p63Ec04861 NA PBac{RB}Ubi-p63Ee02712 NA PBac{RB}Ubi-p63Ee03111 NA
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
cellular process inferred from mutant phenotype (Boutros et al., 2004) phagocytosis, engulfment inferred from mutant phenotype (Stroschein-Stevenson et al., 2006)
Cellular Component
CV term Evidence References
microtubule associated complex inferred from direct assay (Hughes et al., 2008)
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	gene_with_edited_transcript (Graveley et al., 2011) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Ubi-p63E - rngo pull down, anti tag western blot, anti bait coimmunoprecipitation (Morawe et al., 2011)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Ubi-p63E allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 63944 DroID - A comprehensive database of gene and protein interactions. • FBgn0003943 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38456
Orthologs
OrthoDB Orthologs (129) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6D53H1 Dipteran inclusive ortholog search EOG6KWK1S Insect inclusive ortholog search EOG6WH7HG Arthropod inclusive ortholog search EOG6KD51X Metazoa inclusive ortholog search EOG6Q5NJR
Orthologs in Drosophila Species (EOG6D53H1)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Ubi-p63E     Drosophila simulans   Dsim\GD13314     Drosophila sechellia   Dsec\GM14032     Drosophila sechellia   Dsec\GM12582     Drosophila erecta   Dere\GG14240 Y   Drosophila yakuba   Dyak\GE18016     Drosophila yakuba   Dyak\GE20668     Drosophila ananassae   Dana\GF10254 Y   Drosophila ananassae   Dana\GF20300     Drosophila pseudoobscura pseudoobscura   Dpse\GA30006     Drosophila willistoni   Dwil\GK20481 Y   Drosophila virilis   Dvir\GJ16000     Drosophila virilis   Dvir\GJ16068 Y   Drosophila mojavensis   Dmoj\GI12770 Y   Drosophila mojavensis   Dmoj\GI21526
Orthologs in non-Drosophila Dipterans (EOG6KWK1S)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL013536 Y Aedes aegypti Yellow fever mosquito  Aaeg\Ub52 Y Aedes aegypti Yellow fever mosquito  Aaeg\AAEL000795 Y Aedes aegypti Yellow fever mosquito  Aaeg\AAEL008920 Y Aedes aegypti Yellow fever mosquito  Aaeg\AAEL003877 Y Anopheles gambiae Malaria mosquito  Agam\AGAP007927 Y Anopheles gambiae Malaria mosquito  Agam\AGAP002599 Y Anopheles gambiae Malaria mosquito  Agam\AGAP001970 Y Anopheles gambiae Malaria mosquito  Agam\AGAP013742 Y Anopheles gambiae Malaria mosquito  Agam\AGAP001971 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ013324 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ013710 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ801858 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ003589 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ801948 Y
Orthologs in non-Dipteran Insects (EOG6WH7HG)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\RpL40 Y Apis mellifera Western honey bee  Amel\LOC409675 Y Apis mellifera Western honey bee  Amel\RpS27A Y Apis mellifera Western honey bee  Amel\GB53968 Y Apis mellifera Western honey bee  Amel\GB53967 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG023157 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG011275 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG031153 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG013235 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH23514 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH16899 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH17034 Y Atta cephalotes Leafcutter ant  Acep\ACEP16240 Y Atta cephalotes Leafcutter ant  Acep\ACEP11363 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO16664 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO20952 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO18730 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO12442 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL10654 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL16477 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL14420 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL20575 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL13952 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL12274 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL11764 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL10703 Y Linepithema humile Argentine ant  Lhum\LH16507 Y Linepithema humile Argentine ant  Lhum\LH26187 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB27320 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB22886 Y Solenopsis invicta Red fire ant  Sinv\SINV19433 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI005197 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI086543 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI066032 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI000086 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI003315 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI007765 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI000076 Y Bombyx mori Silkmoth  Bmor\BGIBMGA011273 Y Bombyx mori Silkmoth  Bmor\BGIBMGA001415 Y Bombyx mori Silkmoth  Bmor\UBI1 Y Bombyx mori Silkmoth  Bmor\BGIBMGA001549 Y Pediculus humanus Human body louse  Phum\PHUM528640 Y Pediculus humanus Human body louse  Phum\PHUM602270 Y Tribolium castaneum Red flour beetle  Tcas\GLEAN_07754 Y Tribolium castaneum Red flour beetle  Tcas\TC001225 Y Tribolium castaneum Red flour beetle  Tcas\TC009978 Y
Orthologs in non-Insect Arthropods (EOG6KD51X)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\DOCK8 Y Ixodes scapularis Deer tick  Isca\ISCW020697 Y Ixodes scapularis Deer tick  Isca\ISCW010407 Y Ixodes scapularis Deer tick  Isca\ISCW000125 Y
Orthologs in non-Arthropod Metazoa (EOG6Q5NJR)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\ubq-1 Y Caenorhabditis elegans Nematode  Cele\ubq-2 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_004721gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_021496gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_015276gn Y Danio rerio Zebrafish  Drer\si:ch211-202a12.4 Y Danio rerio Zebrafish  Drer\uba52 Y Danio rerio Zebrafish  Drer\ubc Y Danio rerio Zebrafish  Drer\ubb Y Danio rerio Zebrafish  Drer\rps27a Y Xenopus tropicalis Western clawed frog  Xtro\rps27a Y Xenopus tropicalis Western clawed frog  Xtro\uba52 Y Xenopus tropicalis Western clawed frog  Xtro\ubb Y Xenopus tropicalis Western clawed frog  Xtro\ubc Y Gallus gallus Domestic chicken  Ggal\UBB Y Gallus gallus Domestic chicken  Ggal\RPS27A Y Mus musculus House mouse  Mmus\Ubc Y Mus musculus House mouse  Mmus\Gm7866 Y Mus musculus House mouse  Mmus\Rps27a Y Mus musculus House mouse  Mmus\Uba52 Y Mus musculus House mouse  Mmus\Gm5239 Y Mus musculus House mouse  Mmus\Rps27a Y Mus musculus House mouse  Mmus\Ubb Y Mus musculus House mouse  Mmus\Uba52 Y Mus musculus House mouse  Mmus\2810422J05Rik Y Rattus norvegicus Norway rat  Rnor\RGD1564290 Y Rattus norvegicus Norway rat  Rnor\RGD1560997 Y Rattus norvegicus Norway rat  Rnor\LOC688661 Y Rattus norvegicus Norway rat  Rnor\LOC100363614 Y Rattus norvegicus Norway rat  Rnor\Ubc Y Rattus norvegicus Norway rat  Rnor\Rps27a Y Rattus norvegicus Norway rat  Rnor\Uba52 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000033677 Y Rattus norvegicus Norway rat  Rnor\LOC100360548 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000037062 Y Rattus norvegicus Norway rat  Rnor\LOC100363494 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000027417 Y Rattus norvegicus Norway rat  Rnor\LOC100360645 Y Rattus norvegicus Norway rat  Rnor\Rps27a Y Rattus norvegicus Norway rat  Rnor\LOC682397 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000006768 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000043236 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000018208 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000039229 Y Homo sapiens Human  Hsap\RPS27A Y Homo sapiens Human  Hsap\UBA52 Y Homo sapiens Human  Hsap\UBB Y Homo sapiens Human  Hsap\UBC Y
Human Orthologs (4)
Gene OMIM HGNC Hsap\RPS27A     Hsap\UBA52     Hsap\UBB     Hsap\UBC
AAA Orthologs (7) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila erecta Dere\GG14240 Drosophila ananassae Dana\GF10254 Drosophila persimilis Dper\GL16204 Drosophila willistoni Dwil\GK20481 Drosophila virilis Dvir\GJ16068 Drosophila mojavensis Dmoj\GI12770 Drosophila grimshawi Dgri\GH15714
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	16814 y1 w67c23; P{EPgy2}Ubi-p63EEY07341 33405 y1 sc* v1; P{TRiP.HMS00284}attP2/TM3, Sb1
Harvard	- PBac{PB}Ubi-p63Ec04861 - PBac{RB}Ubi-p63Ee02712
VDRC	v102379 P{KK109327}VIE-260B
Genomic Clones ( 1 )
	BACR28E17 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 99 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT20865 GH17513 GH17761 RE10554 SD13292
Other clones	yak-ad_RpL40 yak-ad_RpS27A yak-em_RpL40 yak-em_RpS27A
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT01905 AT02236 AT02712 AT03931 AT07191 AT11075 AT12005 AT12546 AT13748 AT17023 AT18901 AT19438 AT24623 AT27989 AT28274 AT29086 AT29271 AT31695 GH07020 GH07884 GH14434 GH20426 GH27078 GM03088 GM03725 GM06989 GM08037 GM13435 GM25068 GM31421 HL02769 HL05374 LD10342 LD11276 LD15157 LD22170 RE14275 RE26070 RE56703 RE60547 SD13721
Other clones	47227 53040 176124 522039 561928 569058 570003 575669 AT12960 bs03e12 bs17c04 bs20h11 bs22g08 bs23e05 bs25b12 bs26h08 bs37f03 bs46c07 bs46f06 bs48g04 bs54h05 bs57g01 bs60h08 bs61e05 bs61g12 bs70b07 bs73d05 bs80b10 bs85c09 bs85h05 bs86e08 CK01.16D.D12 CK01.117A.F3 Dmel_dig_000488_0704_3705 Dmel_dig_001694_0607_0410 Dmel_dig_010299_0684_3637 Dmel_dig_013180_0626_3020 Dmel_neb_001255_0664_0367 Dmel_neb_014031_0650_3027 Dmel_neb_014123_0401_0551 Dmel_neb_015476_0408_1038 EK175461 ESG014b.E21_H01 ESG017c.E21.1_B07 ESG0115d.B21_G04 ESG0118b.B21_G08 ESG0119a.B21_H09 FGH103A10 FGM325F11
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0003943 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38456
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments	The insertion in the "l(3)05634" line is within the Sc2 gene, rather than affecting Ubi-p63E as stated in FBrf0111489. (Vaskova et al., 2000) The insertion in the "l(3)05634" line is stated to affect Ubi-p63E in this paper. A subsequent publication suggests that this is incorrect and the insertion is in fact in Sc2 (see FBrf0130136). (Spradling et al., 1999)
Other Comments
	S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells. (Stroschein-Stevenson et al., 2006) RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells. (Boutros et al., 2004) RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells. (Boutros et al., 2004) Area matching Drosophila Ubiquitin gene, Acc. No. M22428. (Davies, 2001.3.15) Antibody staining of polytene chromosomes shows that ubiquitin is mainly associated with the compact and stabilized structure that forms the bands rather than with the more decondensed and destabilized protein-DNA structure that forms interbands and puffs. (Izquierdo, 1994) Ubi-p63E expression has been studied in heat shocked aging flies. (Niedzwiecki and Fleming, 1993) Structural gene for ubiquitin (Arribas, Sampedro and Izquierdo, 1988); structure and expression described by Lee, Simon and Lis (1988). Threefold increase in level of gene by heat shock. A Ubi-p63E-lacZ fusion gene introduced by germ line transformation has been expressed at high levels at all life stages tested (embryonic, larval, pupal and adult).
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079185 NM_168043 NM_206272 NM_001274454 RefSeq (Proteins) • NP_523909 NP_728908 NP_995994 NP_001261383 DDBJ / EMBL / GenBank • AAA28821 AAA28822 AAA28823 AAA28824 AAA28825 AAA28826 AAA28997 AAA28999 AAA29000 AAA29001 AAA29002 AAA29003 AAA29004 AAA29005 AAA29006 AAA29007 AAF47806 AAF47806.3 AAG22241 AAG22241.2 AAM50562 AAS64964 AAS64964.1 AGB94078 AI107773 AI238396 AI514032 AI944530 AI945821 AI946105 AI946266 AI946317 AI946403 AI946482 AX093912 AY118702 BG631906 CL528006 CZ469563 CZ480484 CZ480875 M22428 M33013 M33014 M33015 M33016 M33017 M33018 M33019 M33121 M33122 M37604 M37605 M37606 M37607 M37608 M37609 M37610 Entrez Gene - A searchable database of RefSeq genes. • 38456 UniProtKB/Swiss-Prot • P0CG69 UniProtKB/TrEMBL • A4V1F9 Q7JPZ2 Q7JPZ3 Q8MSM5 Q24575 Q24576 Q24577 Q27927 Q99347 Q99348 Q99349 Q99350 Q99351
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Ubiquitin (IPR000626) Ubiquitin conserved site (IPR019954) Ubiquitin supergroup (IPR019955) Ubiquitin subgroup (IPR019956) PDB - Protein Data Bank. An information portal to biological macromolecular structures • 1AAR 1TBE 1UBI 1UBQ
Linkouts
	BioGRID - A database of protein and genetic interactions • 63944 DroID - A comprehensive database of gene and protein interactions. • FBgn0003943 DRSC - Results from RNAi screens. • FBgn0003943 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003943 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11624-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0003943 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38456 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38456 modMine - Data generated by the modENCODE project. • FBgn0003943
Synonyms & Secondary IDs ( 21 )
Reported As
Symbol Synonym	CG11624 (Ramet et al., 2002, Fulton et al., 2001, Qin et al., 2005, Keleman et al., 2009.8.5, Hughes et al., 2008, Ni et al., 2010.12.1) DmUb (Shih et al., 2002) DmUbi-p63E (Hoe et al., 2011) Ub (Kanuka et al., 2003, Huang et al., 1995, Koh et al., 2006, Koh et al., 2006, Moberg et al., 2005) ubi (Witzberger et al., 2008) ubi63E (Ryoo et al., 2002, Ryoo et al., 2002) Ubi63E (Bernards and Hariharan, 2001, Fernandez-Funez et al., 2000) Ubi63p (Stielow et al., 2008) Ubi-p (Vaskova et al., 2000, Lindsley and Zimm, 1992) Ubip (Maroni, 1994) Ubi-p63E (Marygold, 2007.1.12, Ulvila et al., 2006, Stroschein-Stevenson et al., 2006, Gim et al., 2001, Ma et al., 2006, Lawniczak and Begun, 2004, Zhang et al., 2007, Fisher et al., 2008, Munoz-Soriano et al., 2012) ubi-p63E (Zhou et al., 2008) Ubi-P63e (Qin et al., 2005) Ubip63E (Munoz-Soriano et al., 2012) Ubiq (Wesley and Mok, 2003) Ubp (Fischer-Vize et al., 1997)
Name Synonym	polyubiquitin (Niedzwiecki and Fleming, 1993, ) ubiquitin (Sakata et al., 2004, Auluck et al., 2002, Finley et al., 2003, Park et al., 2005, Lu and Bilder, 2005, Moberg et al., 2005, Simonsen et al., 2007, Murphey and Godenschwege, 2002, Schmitz et al., 2003) Ubiquitin (Zoghbi and Botas, 2002, Noll et al., 2000, Pham and Sauer, 2000, Herz et al., 2006, Wesley and Mok, 2003) Ubiquitin-63E (Nybakken et al., 2005, Gim et al., 2001, Qin et al., 2005) Ubiquitin-polymeric (Lindsley and Zimm, 1992)
Secondary FlyBase IDs
References ( 93 )
Generate a list of	All references relating to this gene ( 93 )
List References by type	Research paper  ( 58 ) Supplementary material  ( 9 ) Review  ( 3 ) Erratum  ( 1 ) Personal communication to FlyBase  ( 11 ) Abstract  ( 4 ) FlyBase analysis  ( 1 ) Book  ( 1 ) Patent  ( 1 ) DNA/RNA sequence record  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 5 )
	Staller et al., 2013, Genetics 193(1): 51--61 Depleting Gene Activities in Early Drosophila Embryos with the "Maternal-Gal4-shRNA" System. [FBrf0220341] Munoz-Soriano et al., 2012, J. Mol. Neurosci. 48(1): 136--143 Septin 4, the Drosophila Ortholog of Human CDCrel-1, Accumulates in parkin Mutant Brains and is Functionally Related to the Nedd4 E3 Ubiquitin Ligase. [FBrf0219099] Franco et al., 2011, Mol. Cell. Proteomics 10(5): M110.002188 A Novel Strategy to Isolate Ubiquitin Conjugates Reveals Wide Role for Ubiquitination during Neural Development. [FBrf0213919] Hoe et al., 2011, Aging 3(3): 237--261 Ubiquitin over-expression phenotypes and ubiquitin gene molecular misreading during aging in Drosophila melanogaster. [FBrf0213373] Morawe et al., 2011, J. Cell Biol. 193(1): 71--80 Loss of the extraproteasomal ubiquitin receptor Rings lost impairs ring canal growth in Drosophila oogenesis. [FBrf0213374] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...