Ub, ubiquitin, polyubiquitin, Ubi-p, ubi63E
Please see the JBrowse view of Dmel\Ubi-p63E for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Apparent introns not annotated: probable artifacts due to repetitive sequence.
Gene model reviewed during 5.46
4.4 (northern blot)
The group(s) of polypeptides indicated below share identical sequence to each other.
231 (aa)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ubi-p63E using the Feature Mapper tool.
Ubi-p63E transcripts are observed in all stages assayed. A reporter construct was used to show that they are expressed in a tissue-general pattern in all life stages assayed.
GBrowse - Visual display of RNA-Seq signals
View Dmel\Ubi-p63E in GBrowse 2Same map position as 63F early ecdysone-induced puff.
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Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
The insertion in the "l(3)05634" line is within the Sc2 gene, rather than affecting Ubi-p63E as stated in FBrf0111489.
The insertion in the "l(3)05634" line is stated to affect Ubi-p63E in this paper. A subsequent publication suggests that this is incorrect and the insertion is in fact in Sc2 (see FBrf0130136).
S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.
RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.
RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.
Area matching Drosophila Ubiquitin gene, Acc. No. M22428.
Antibody staining of polytene chromosomes shows that ubiquitin is mainly associated with the compact and stabilized structure that forms the bands rather than with the more decondensed and destabilized protein-DNA structure that forms interbands and puffs.
Ubi-p63E expression has been studied in heat shocked aging flies.
Structural gene for ubiquitin (Arribas, Sampedro and Izquierdo, 1988); structure and expression described by Lee, Simon and Lis (1988). Threefold increase in level of gene by heat shock. A Ubi-p63E-lacZ fusion gene introduced by germ line transformation has been expressed at high levels at all life stages tested (embryonic, larval, pupal and adult).
Named 'magellan' because mutant spermatocytes arrest development with abnormal structures that resemble Magellanic clouds.