bx, pbx, Cbx, bxd, bithorax
transcription factor - homeodomain - Antp class - Mutations of result in transformation of the dorsal and ventral appendages of the third thoracic segment (the haltere and third leg) into their counterparts on the second thoracic segment (wing and second leg).
Gene model reviewed during 5.54
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Gene model reviewed during 5.41
Gene model reviewed during 5.55
4.3, 3.2 (northern blot)
None of the polypeptides share 100% sequence identity.
The QA motif is able to mediate transcriptional repression.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ubx using the Feature Mapper tool.
Comment: expressed from mesothoracic segment to abdominal segment 5
The major domain of Ubx expression in the embryonic CNS is parasegment 6, with weaker expression in parasegment 5 (posterior T2 and anterior T3) and an isolated cluster of neurons in the midline of parasegment 4. Posterior to A1, Ubx expression is weak and spotty but still occurs in some neurons through A7. Within parasegment 6, the great majority of the neurons show strong Ubx expression.
Ubx expression begins in NB5-6A at embryonic stage 11, and is subsequently expressed in earlier born cells in this lineage in segment A1-A7.
Ubx expression in the adult dorsal vessel is restricted to the svp-expressing myocytes (and is absent from the tin-expressing myocytes. It is expressed in both up until 24hr APF, begins to be repressed in the tin-expressing cells at 30 hr APF, and is undetectable in these cells by 48 hrs.
The Ubx protein is expressed in the nuclei of larval fat body cells with an anterior boundary of around T3 and a posterior limit near A6/A7. Expression occurs in all nuclei of this region and specific labeling of polytene chromosome bands can be mapped.
Ubx protein is expressed in all cells of the peripodial epithelium of the wint disc.
Protein is detected in the midsection of the embryonic dorsal vessel. The protein is expressed in cardioblasts of abdominal segments A2-A5. Low level expression of Ubx is also observed in pericardial cells of these segments. The cardiac segment of the dorsal vessel contains barely detectable levels of Ubx protein.
Ubx protein is expressed at low levels in all cells of the dorsal vessel between abdominal segment 2 and the posterior tip of the embryonic heart.
Ubx expression is low in the cardiac tube compared to the gut and ectoderm. Within the cardiac tube, expression is strongest in the cardial and pericardial cells of the aorta from segment A2 to the middle of segment A5.
Ubiquitously expressed wg leads to the anterior expansion of the domain of Ubx expression in the visceral mesoderm to encompass parasegments 6 and 7. Ubiquitous dpp has no effect on the domain of Ubx expression.
Mutations in the shv region of dpp cause a range of effects on Ubx expression. Generally, the Ubx expression domain is narrowed or the Ubx protein level is reduced. abd-A mutations cause expansion of the domain of Ubx expression in the visceral mesoderm to include the entire posterior midgut.
Antp protein is first detected at germ band retraction stage in a 6-7 cell width stripe in the midgut visceral mesoderm and the ectoderm of parasegment 7.
The Ubx expression domain is twice as wide in homozygous ftz mutant embryos as in wild type. Embryos homozygous for eve3 showed no Ubx staining but there is some staining in embryos homozygous for eve4. Normal homeotic gene function is seen in embryos homozygous for en59, en54, en55, wgl-17, opa1, h41, odd5, prd4 and runB102. No Ubx gene expression is seen in ftz,prd double mutant embryos, some staining is seen in opa,prd double mutant embryos and there is normal staining in odd,eve double mutant embryos. The Ubx domain is in the right position in KrB206 mutants, shifted posteriorly in kni mutants and shifted anteriorly in hb mutants.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Ubx in GBrowse 2