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General Information
Symbol
Dmel\Ubx
Species
D. melanogaster
Name
Ultrabithorax
Annotation Symbol
CG10388
Feature Type
FlyBase ID
FBgn0003944
Gene Model Status
Stock Availability
Gene Snapshot
Ultrabithorax (Ubx) encodes a homeodomain transcription factor involved in cell fate decisions, cell proliferation and organ identity. Ubx mutants can show a second set of wings due to appendage transformation. [Date last reviewed: 2019-03-14]
Also Known As
bx, pbx, Cbx, bithorax, bxd
Key Links
Genomic Location
Cytogenetic map
Sequence location
3R:16,656,623..16,734,426 [-]
Recombination map
3-59
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Protein Family (UniProt)
Belongs to the Antp homeobox family. (P83949)
Summaries
Gene Group (FlyBase)
BITHORAX COMPLEX -
The bithorax complex (BX-C) is one of two Hox gene complexes. Hox genes encode homeodomain transcription factors. The BX-C controls the identity of the segments that contribute to the posterior thorax and each abdominal segment of the fly. (Adapted from FBrf0190304).
HOX-LIKE HOMEOBOX TRANSCRIPTION FACTORS -
HOX-like (HOXL) homeobox transcription factors are sequence-specific DNA binding proteins that regulate transcription. They encompass transcription factors encoded by the Hox genes of the Antennapedia and the Bithorax gene complexes and genes closely related in sequence. HOXL transcription factors are major regulators of animal development. (Adapted from FBrf0232555).
Protein Function (UniProtKB)
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds the consensus region 5'-TTAAT[GT][GA]-3'. This homeotic protein controls development of the cells in the posterior thoracic and first abdominal segments. It activates the synthesis of the decapentaplegic (DPP) growth factor.
(UniProt, P83949)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
abx: anterobithorax (E.B. Lewis)
Homozygotes show variable tranformations of the anteriormost portion of the third thoracic segment (T3) toward the corresponding part of T2. Homozygotes also show variable tranformations of posterior T2 to posterior T1. The latter effect is enhanced by low temperature. Partially complements and shows transvection with bx1, bx3, and bx34e. abx/pbx has the posterior portion of the distal segment of the haltere very slightly transformed into wing tissue; abx/pbx2 is similar if heterozygous for a rearrangement that suppresses transvection.
bx: bithorax (E.B. Lewis)
thumb
bx: bithorax
From Bridges and Morgan, 1923, Carnegie Inst. Washington Publ. No. 327: 152.
Homozygote has anterior portion of third thoracic segment (T3) transformed toward corresponding region of second (T2). The extent of this transformation is allele dependent and is most extreme in bx3 and weakest in bx4. Although the transformations caused by most bx alleles are uniform, those caused by bx1 and bx34eprv are highly variable. At 17C several bx alleles show weak and variable transformations of posterior T2 to posterior T1. bx3, bx8, and bxG over pbx show a very slight pbx effect (as described for abx) if heterozygous for a rearrangement that suppresses transvection.
bxd: bithoraxoid (E.B. Lewis)
thumb
bxd: bithoraxoid
From Bridges and Morgan, 1923, Carnegie Inst. Washington Publ. No. 327: 225.
Homozygotes show transformation of the anterior first abdominal segment (A1) to the corresponding region of the third thoracic segment (T3). In addition, bxd homozygotes have posterior T3 and posterior A1 transformed toward posterior T2. Hemizygotes for the stronger bxd alleles show (with variable expression) formation of one or a pair of well-developed thoracic legs and, rarely, an extra haltere on A1; the frequency of these abdominal halteres is greatly enhanced in hemizygotes for bxd9 iab2K. The A1 legs in bxd hemizygotes contain underdeveloped posterior compartments, indicating that posterior A1 is partially transformed toward thorax.
Cbx: Contrabithorax (E.B. Lewis)
Cbx1/+ has a strong transformation of the posterior region of the second thoracic segment (T2) toward the corresponding region of the third (T3), and a weak and variable transformation of anterior T2 toward anterior T3. The Cbx1 homozygote differs in having a stronger, but still variable, transformation of anterior T2 toward T3. Cbx1/Ubx has a slight enhancement of the Ubx phenotype (see also su-Cbx). Cbx2 has both anterior and posterior regions of T2 moderately transformed toward T3. CbxHm affects only the wing, which is strongly transformed to haltere. Flies carrying two doses of CbxHm plus a normal allele have a virtually complete transformation of wing to haltere (as figured in Lewis, 1982). Cbx2 and CbxHm have inseparable recessive bxd effects. Cbx3/+ transforms anterior portions of T2 variably toward anterior T3. It has no effect in posterior T2. For an overview of the effects of Cbx mutants on specific structures see Table 1: Lewis, 1982.
pbx: postbithorax
Adult homozygotes and hemizygotes have posterior region of third thoracic segment (T3) transformed toward corresponding region of the second (T2).
Uab: Ultraabdominal (E.B. Lewis)
Uab1, Uab2, and Uab4 cause A1 to transform toward A2. Uab5 causes A1 and A2 to transform toward A3. Uab1 is an intra-complex inversion with a breakpoint in the bxd region, Uab2 is associated with a Uab mutation, the Uab4 breakpoint is an iab-3 mutation, and the Uab5 breakpoint is a weak bxd mutation. Reversion studies show that Uab1, Uab4, and Uab5 cause abnormal expression of abd-A domain functions in A1.
Ubx: Ultrabithorax (E.B. Lewis)
Larvae homozygous and hemizygous for strong Ubx mutants, such as the Ubx1-type, have the ventral setal bands or "hooklets" of the first abdominal segment (A1) and T3 transformed toward those of T2; dorsally, the hair patterns of posterior T2 and posterior T3 are transformed toward posterior T1; Keilin organs with 2 hairs appear on A1; ventral pits appear on segments A1 thru A7; two extra sets of anterior spiracles appear, one on T3 and one on A1. Homozygotes die, usually as tiny third-instar larvae, but occasionally grow to a normal-sized third-instar larvae and may pupate. Homozygotes of some weaker alleles, such as Ubx61d, survive to adult stage and show weak bx, bxd, and pbx effects, especially in the haltere, and A1 is generally reduced.
Summary (Interactive Fly)
transcription factor - homeodomain - Antp class - Mutations of result in transformation of the dorsal and ventral appendages of the third thoracic segment (the haltere and third leg) into their counterparts on the second thoracic segment (wing and second leg).
Gene Model and Products
Number of Transcripts
6
Number of Unique Polypeptides
6

Please see the GBrowse view of Dmel\Ubx or the JBrowse view of Dmel\Ubx for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.54
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Gene model reviewed during 5.41
Gene model reviewed during 5.55
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0083347
4282
389
FBtr0083348
3628
346
FBtr0083349
4231
372
FBtr0083350
2784
363
FBtr0083351
3117
380
FBtr0083352
4180
355
Additional Transcript Data and Comments
Reported size (kB)
4.3, 3.2 (northern blot)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0082793
40.0
389
9.07
FBpp0082794
35.4
346
9.55
FBpp0082795
38.2
372
9.09
FBpp0082796
37.2
363
9.52
FBpp0082797
39.1
380
9.49
FBpp0089155
36.3
355
9.11
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
Gel-shift analysis shows specific binding of Ubx protein to fragments from the Pc gene region.
External Data
Domain
The QA motif is able to mediate transcriptional repression.
(UniProt, P83949)
Crossreferences
PDB - An information portal to biological macromolecular structures
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ubx using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (30 terms)
Molecular Function (6 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
inferred from direct assay
(assigned by UniProt )
inferred from physical interaction with FLYBASE:DIP1; FB:FBgn0024807
inferred from physical interaction with UniProtKB:P40427
(assigned by UniProt )
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
inferred from electronic annotation with InterPro:IPR001827
(assigned by InterPro )
inferred from biological aspect of ancestor with PANTHER:PTN002388214
(assigned by GO_Central )
Biological Process (21 terms)
Terms Based on Experimental Evidence (17 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:Asx; FB:FBgn0261823
inferred from mutant phenotype
inferred from expression pattern
inferred from direct assay
(assigned by UniProt )
inferred from mutant phenotype
Terms Based on Predictions or Assertions (6 terms)
CV Term
Evidence
References
traceable author statement
(assigned by UniProt )
inferred from biological aspect of ancestor with PANTHER:PTN002388214
(assigned by GO_Central )
traceable author statement
traceable author statement
inferred from biological aspect of ancestor with PANTHER:PTN002902589
(assigned by GO_Central )
Cellular Component (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
inferred from direct assay
(assigned by UniProt )
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN002388214
(assigned by GO_Central )
non-traceable author statement
(assigned by UniProt )
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
dorsal ectoderm anlage

Comment: anlage in statu nascendi

mesectoderm anlage

Comment: anlage in statu nascendi

mesoderm anlage

Comment: anlage in statu nascendi

ventral ectoderm anlage

Comment: anlage in statu nascendi

northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic mesothoracic segment & embryonic metathoracic segment

Comment: expressed from mesothoracic segment to abdominal segment 5

embryonic abdominal segment 1 -- embryonic abdominal segment 5

Comment: expressed from mesothoracic segment to abdominal segment 5

Additional Descriptive Data
The major domain of Ubx expression in the embryonic CNS is parasegment 6, with weaker expression in parasegment 5 (posterior T2 and anterior T3) and an isolated cluster of neurons in the midline of parasegment 4. Posterior to A1, Ubx expression is weak and spotty but still occurs in some neurons through A7. Within parasegment 6, the great majority of the neurons show strong Ubx expression.
Ubx expression begins in NB5-6A at embryonic stage 11, and is subsequently expressed in earlier born cells in this lineage in segment A1-A7.
Ubx expression in the adult dorsal vessel is restricted to the svp-expressing myocytes (and is absent from the tin-expressing myocytes. It is expressed in both up until 24hr APF, begins to be repressed in the tin-expressing cells at 30 hr APF, and is undetectable in these cells by 48 hrs.
The Ubx protein is expressed in the nuclei of larval fat body cells with an anterior boundary of around T3 and a posterior limit near A6/A7. Expression occurs in all nuclei of this region and specific labeling of polytene chromosome bands can be mapped.
Ubx protein is expressed in all cells of the peripodial epithelium of the wint disc.
Protein is detected in the midsection of the embryonic dorsal vessel. The protein is expressed in cardioblasts of abdominal segments A2-A5. Low level expression of Ubx is also observed in pericardial cells of these segments. The cardiac segment of the dorsal vessel contains barely detectable levels of Ubx protein.
Ubx protein is expressed at low levels in all cells of the dorsal vessel between abdominal segment 2 and the posterior tip of the embryonic heart.
Ubx expression is low in the cardiac tube compared to the gut and ectoderm. Within the cardiac tube, expression is strongest in the cardial and pericardial cells of the aorta from segment A2 to the middle of segment A5.
Ubiquitously expressed wg leads to the anterior expansion of the domain of Ubx expression in the visceral mesoderm to encompass parasegments 6 and 7. Ubiquitous dpp has no effect on the domain of Ubx expression.
In wghs.P embryos, after heat shock, Ubx protein is only seen in those cells that do not express en. This is a similar expression pattern to that found in nkd mutant embryos.
The posterior dpp stripe coincides with Ubx expression in parasegment 7. Ubx expression is unaffected in dpps4 embryos.
In abd-A- embryos, Ubx protein levels are higher than in wild type embryos in posterior compartments of metameres of the abd-A domain suggesting that abd-A downregulates Ubx in these domains.
Mutations in the shv region of dpp cause a range of effects on Ubx expression. Generally, the Ubx expression domain is narrowed or the Ubx protein level is reduced. abd-A mutations cause expansion of the domain of Ubx expression in the visceral mesoderm to include the entire posterior midgut.
Antp protein is first detected at germ band retraction stage in a 6-7 cell width stripe in the midgut visceral mesoderm and the ectoderm of parasegment 7.
The Ubx expression domain is twice as wide in homozygous ftz mutant embryos as in wild type. Embryos homozygous for eve3 showed no Ubx staining but there is some staining in embryos homozygous for eve4. Normal homeotic gene function is seen in embryos homozygous for en59, en54, en55, wgl-17, opa1, h41, odd5, prd4 and runB102. No Ubx gene expression is seen in ftz,prd double mutant embryos, some staining is seen in opa,prd double mutant embryos and there is normal staining in odd,eve double mutant embryos. The Ubx domain is in the right position in KrB206 mutants, shifted posteriorly in kni mutants and shifted anteriorly in hb mutants.
Marker for
 
Subcellular Localization
CV Term
Evidence
References
inferred from direct assay
(assigned by UniProt )
Expression Deduced from Reporters
Reporter: P{22UZ}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{35UZ}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{abx6.8a}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{abx6.8HS}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{abx20}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{BBI}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{Bhz}
Stage
Tissue/Position (including subcellular localization)
Reference
parasegment 3 of visceral mesoderm

Comment: parasegment 3 & 6-9

parasegment 6 of visceral mesoderm

Comment: parasegment 3 & 6-9

parasegment 7 of visceral mesoderm

Comment: parasegment 3 & 6-9

parasegment 9 of visceral mesoderm

Comment: parasegment 3 & 6-9

Reporter: P{BI}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{BRE-Ubx-lacZ}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{bxd-5.6}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{bxd14.5}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{ComboA}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{ComboB}
Stage
Tissue/Position (including subcellular localization)
Reference
Stage
Tissue/Position (including subcellular localization)
Reference
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{lacZUbx.pbx2xPS}
Stage
Tissue/Position (including subcellular localization)
Reference
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{lacZUbx.pbxPP}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{lacZUbx.pbxPPa}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{lacZUbx.pbxPPb}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{lacZUbx.pbxPS}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{lacZUbx.pbxPSd}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{lacZ}68-77
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{pbxAS}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{pbxSB}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{RPhz}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{Ubx(ΔBhz)lacZ}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{Ubx-lacZ.ABX}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{Ubx-lacZ.BXD}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{Ubx-lacZ.PBX}
Stage
Tissue/Position (including subcellular localization)
Reference
Stage
Tissue/Position (including subcellular localization)
Reference
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Ubx in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 361 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 91 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Ubx
Transgenic constructs containing regulatory region of Ubx
Deletions and Duplications ( 69 )
Partially duplicated in
Disrupted in
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
abdominal anterior fascicle & abdominal segment 1 & adult
abdominal posterior fascicle & abdominal segment 1 & adult
abdominal segment 1 & haltere | ectopic
abdominal segment 1 & haltere | ectopic (with Df(3R)Ubx109)
abdominal segment 1 & Keilin's organ | ectopic
abdominal segment 1 & metathoracic leg | ectopic
abdominal segment 1 & metathoracic leg | ectopic (with Df(3R)Ubx109)
abdominal segment 1 & puparium & myoblast, with Scer\GAL4how-24B
abdominal segment 1 & puparium & myoblast, with Scer\GAL4NP5169
abdominal segment 1 & puparium & myofibril, with Scer\GAL4how-24B
abdominal segment 1 & puparium & myofibril, with Scer\GAL4NP5169
abdominal segment 2 & puparium & myoblast, with Scer\GAL4how-24B
abdominal segment 2 & puparium & myoblast, with Scer\GAL4NP5169
abdominal segment 2 & puparium & myofibril, with Scer\GAL4how-24B
abdominal segment 2 & puparium & myofibril, with Scer\GAL4NP5169
abdominal segment 3 & puparium & myoblast, with Scer\GAL4how-24B
abdominal segment 3 & puparium & myoblast, with Scer\GAL4NP5169
abdominal segment 3 & puparium & myofibril, with Scer\GAL4how-24B
abdominal segment 3 & puparium & myofibril, with Scer\GAL4NP5169
abdominal segment 4 & puparium & myoblast, with Scer\GAL4how-24B
abdominal segment 4 & puparium & myoblast, with Scer\GAL4NP5169
abdominal segment 4 & puparium & myofibril, with Scer\GAL4how-24B
abdominal segment 4 & puparium & myofibril, with Scer\GAL4NP5169
abdominal segment 5 & puparium & myoblast | ectopic, with Scer\GAL4how-24B
abdominal segment 5 & puparium & myoblast | ectopic, with Scer\GAL4NP5169
adult muscle system & abdominal segment 1
chordotonal organ & axon
chordotonal organ & axon | conditional ts
chordotonal organ & mesothoracic segment
chordotonal organ & metathoracic segment
chordotonal organ & prothoracic segment
dendrite & dendritic arborising neuron, with Scer\GAL4ppk.PG
denticle & embryonic head segment, with Scer\GAL4arm.PS
denticle belt & abdominal segment 9, with Scer\GAL469B
ectoderm & metathoracic segment
embryonic abdominal segment 1 & abdominal ventral oblique muscle 6 | ectopic, with Scer\GAL4how-24B
embryonic abdominal segment 1 & abdominal ventral transverse muscle 1 | ectopic, with Scer\GAL4how-24B
embryonic thoracic segment & ventral longitudinal muscle, with Scer\GAL4how-24B
haltere & macrochaeta
haltere & macrochaeta | ectopic
Keilin's organ & abdominal segment 1
mesothoracic laterotergite & macrochaeta | ectopic
mesothoracic laterotergite & macrochaeta | ectopic (with Ubx6.28)
mesothoracic laterotergite & macrochaeta | ectopic (with UbxΔQA)
mesothoracic segment & glial cell | conditional ts
metathoracic segment & glial cell | conditional ts
peripheral nervous system & mesothoracic segment | conditional ts
peripheral nervous system & metathoracic segment | conditional ts
peripheral nervous system & parasegment 5
peripheral nervous system & parasegment 6
peripheral nervous system & prothoracic segment | conditional ts
peripodial epithelium & dorsal mesothoracic disc, with Scer\GAL4426
peripodial epithelium & dorsal mesothoracic disc, with Scer\GAL4vg.PM
prothoracic segment & glial cell | conditional ts
tarsal segment 1 & leg sensillum, with Scer\GAL4sca-109-68
thoracic segment & abdominal ventral acute muscle 1 | precursor | ectopic, with Scer\GAL4how-24B
trichome & mesothoracic femur | posterior
trichome & mesothoracic leg
trichome & mesothoracic leg (with Ubx6.28)
trichome & mesothoracic leg (with UbxΔQA)
trichome & metathoracic leg
trichome & metathoracic leg (with Ubx6.28)
trichome & metathoracic leg (with UbxΔQA)
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (31)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
3 of 15
No
Yes
3 of 15
No
Yes
3 of 15
No
Yes
2 of 15
No
No
 
2 of 15
No
No
2 of 15
No
No
 
2 of 15
No
No
2 of 15
No
No
1 of 15
No
No
1 of 15
No
No
 
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
 
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
 
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
 
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
 
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (31)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
3 of 15
No
Yes
 
3 of 15
No
Yes
3 of 15
No
Yes
 
3 of 15
No
Yes
 
3 of 15
No
Yes
3 of 15
No
Yes
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
 
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
 
1 of 15
No
No
1 of 15
No
No
 
1 of 15
No
No
 
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Rattus norvegicus (Norway rat) (38)
3 of 13
Yes
Yes
3 of 13
Yes
No
3 of 13
Yes
No
2 of 13
No
Yes
2 of 13
No
No
2 of 13
No
No
2 of 13
No
No
2 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
Yes
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (28)
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
Danio rerio (Zebrafish) (41)
3 of 15
Yes
No
3 of 15
Yes
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
 
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
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