transmembrane protein involved in Sex lethal splicing - a component of mRNA NA methylosome, a complex of nuclear proteins - translationally represses to prevent dosage compensation in females
Gene model reviewed during 5.52
There is only one protein coding transcript and one polypeptide associated with this gene
Component of the WMM complex, a N6-methyltransferase complex composed of a catalytic subcomplex, named MAC, and of an associated subcomplex, named MACOM (PubMed:27919077, PubMed:29535189, PubMed:29555755). The MAC subcomplex is composed of Ime4/Mettl3 and Mettl14 (PubMed:29535189, PubMed:29555755). The MACOM subcomplex is composed of fl(2)d, Flacc/Xio, Hakai, vir, and, in some cases of nito (PubMed:27919077,PubMed:29535189, PubMed:29555755). Part of a complex containing fl(2)d, Sxl and vir (PubMed:12444081).
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\vir using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\vir in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
vir is a complex locus harbouring female-specific functions that are required for sex determination and dosage compensation as well as functions that are zygotically required for viability in both sexes. Genetic and molecular analyses suggest that vir is required for female-specific splicing of Sxl and of tra pre-mRNA.