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Gene Dmel\vir

General Information
Symbol	Dmel\vir	Species	D. melanogaster
Name	virilizer	Annotation symbol	CG3496
Feature type	protein_coding_gene	FlyBase ID	FBgn0003977
Gene Model Status	Current	Stock availability	2 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map	2-103.3
Cytogenetic map	59D8-59D9	Sequence location	2R:19,247,786..19,253,777 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene virilizer is referred to in FlyBase by the symbol Dmel\vir (CG3496, FBgn0003977). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: nucleic acid binding. There is experimental evidence that it is involved in the biological process: RNA splicing, via transesterification reactions; border follicle cell migration. 16 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; mesothoracic tergum. It has one annotated transcript and one annotated polypeptide. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1630976_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of vir. Gene sequence location is 2R:19247786..19253777.
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	vir: virilizer A new undescribed gene involved in sex determination. Female sterile; may be temperature sensitive.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features BKN20518 HFA04377
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 59D8-59D9   Limits computationally determined from genome sequence between P{lacW}l(2)k07136k07136 and P{lacW}l(2)s4830s4830&P{lacW}chrwk06908
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location	2-103.3   2-103.9 (Hilfiker and Nothiger, 1991)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\vir for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	DGC clone LD23371 appears problematic: incomplete CDS
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) vir-RA FBtr0072037  NM_080161   5695   1854
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein vir-PA   FBpp0071946   209.0   1854   5.79     NP_524900   AAF46988
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA539136   AE013599 AAF46988   AF281363 AAK12372   AI515999   CK604255   CO155954   CO293797   CO320987   CO321765   CO340497   EC074333   EC221537   EC247260   EC258178   EW712748   EW712998
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9W1R5
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 4 -- 17   somatic cell   (Niessen et al., 2001) Comment:expression peaks during gastrulation northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 17   organism   (Niessen et al., 2001) Comment:1-17 hr AEL adult stage   organism   (Niessen et al., 2001)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0003977    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0003977 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0003977 expression level Developmental Stage   Expression Level embryo 00-02hr    1829 embryo 02-04hr    3762 embryo 04-06hr    3634 embryo 06-08hr    2510 embryo 08-10hr    1954 embryo 10-12hr    1375 embryo 12-14hr    996 embryo 14-16hr    1196 embryo 16-18hr    694 embryo 18-20hr    484 embryo 20-22hr    468 embryo 22-24hr    422 larva L1    642 larva L2    545 larva L3 12hr old    471 larva L3 puffstage 1-2    431 larva L3 puffstage 3-6    648 larva L3 puffstage 7-9    614 white prepupae new    689 white prepupae 12hr    795 white prepupae 24hr    1077 pupae 2d postWPP    529 pupae 3d postWPP    251 pupae 4d postWPP    299 adult male 01day    357 adult male 05day    407 adult male 30day    440 adult female 01day    703 adult female 05day    772 adult female 30day    829 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1829) embryo 02-04hr  (3762) embryo 04-06hr  (3634) embryo 06-08hr  (2510) embryo 08-10hr  (1954) embryo 10-12hr  (1375) embryo 12-14hr  (996) embryo 14-16hr  (1196) embryo 16-18hr  (694) embryo 18-20hr  (484) embryo 20-22hr  (468) embryo 22-24hr  (422) larva L1  (642) larva L2  (545) larva L3 12hr old  (471) larva L3 puffstage 1-2  (431) larva L3 puffstage 3-6  (648) larva L3 puffstage 7-9  (614) white prepupae new  (689) white prepupae 12hr  (795) white prepupae 24hr  (1077) pupae 2d postWPP  (529) pupae 3d postWPP  (251) pupae 4d postWPP  (299) adult male 01day  (357) adult male 05day  (407) adult male 30day  (440) adult female 01day  (703) adult female 05day  (772) adult female 30day  (829) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (1829) embryo 02-04hr  (3762) embryo 04-06hr  (3634) embryo 06-08hr  (2510) embryo 08-10hr  (1954) embryo 10-12hr    1375 embryo 12-14hr    996 embryo 14-16hr    1196 embryo 16-18hr    694 embryo 18-20hr    484 embryo 20-22hr    468 embryo 22-24hr    422 larva L1    642 larva L2    545 larva L3 12hr old    471 larva L3 puffstage 1-2    431 larva L3 puffstage 3-6    648 larva L3 puffstage 7-9    614 white prepupae new    689 white prepupae 12hr    795 white prepupae 24hr    1077 pupae 2d postWPP    529 pupae 3d postWPP    251 pupae 4d postWPP    299 adult male 01day    357 adult male 05day    407 adult male 30day    440 adult female 01day    703 adult female 05day    772 adult female 30day    829 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1829 embryo 02-04hr    3762 embryo 04-06hr    3634 embryo 06-08hr    2510 embryo 08-10hr    1954 embryo 10-12hr    1375 embryo 12-14hr    996 embryo 14-16hr    1196 embryo 16-18hr    694 embryo 18-20hr    484 embryo 20-22hr    468 embryo 22-24hr    422 larva L1    642 larva L2    545 larva L3 12hr old    471 larva L3 puffstage 1-2    431 larva L3 puffstage 3-6    648 larva L3 puffstage 7-9    614 white prepupae new    689 white prepupae 12hr    795 white prepupae 24hr    1077 pupae 2d postWPP    529 pupae 3d postWPP    251 pupae 4d postWPP    299 adult male 01day    357 adult male 05day    407 adult male 30day    440 adult female 01day    703 adult female 05day    772 adult female 30day    829 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1829 embryo 02-04hr    3762 embryo 04-06hr    3634 embryo 06-08hr    2510 embryo 08-10hr    1954 embryo 10-12hr    1375 embryo 12-14hr    996 embryo 14-16hr    1196 embryo 16-18hr    694 embryo 18-20hr    484 embryo 20-22hr    468 embryo 22-24hr    422 larva L1    642 larva L2    545 larva L3 12hr old    471 larva L3 puffstage 1-2    431 larva L3 puffstage 3-6    648 larva L3 puffstage 7-9    614 white prepupae new    689 white prepupae 12hr    795 white prepupae 24hr    1077 pupae 2d postWPP    529 pupae 3d postWPP    251 pupae 4d postWPP    299 adult male 01day    357 adult male 05day    407 adult male 30day    440 adult female 01day    703 adult female 05day    772 adult female 30day    829 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0003977 expression level Developmental Stage   Expression Level embryo 00-02hr    1829 embryo 02-04hr    3762 embryo 04-06hr    3634 embryo 06-08hr    2510 embryo 08-10hr    1954 embryo 10-12hr    1375 embryo 12-14hr    996 embryo 14-16hr    1196 embryo 16-18hr    694 embryo 18-20hr    484 embryo 20-22hr    468 embryo 22-24hr    422 larva L1    642 larva L2    545 larva L3 12hr old    471 larva L3 puffstage 1-2    431 larva L3 puffstage 3-6    648 larva L3 puffstage 7-9    614 white prepupae new    689 white prepupae 12hr    795 white prepupae 24hr    1077 pupae 2d postWPP    529 pupae 3d postWPP    251 pupae 4d postWPP    299 adult male 01day    357 adult male 05day    407 adult male 30day    440 adult female 01day    703 adult female 05day    772 adult female 30day    829 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1829) embryo 02-04hr  (3762) embryo 04-06hr  (3634) embryo 06-08hr  (2510) embryo 08-10hr  (1954) embryo 10-12hr  (1375) embryo 12-14hr  (996) embryo 14-16hr  (1196) embryo 16-18hr  (694) embryo 18-20hr  (484) embryo 20-22hr  (468) embryo 22-24hr  (422) larva L1  (642) larva L2  (545) larva L3 12hr old  (471) larva L3 puffstage 1-2  (431) larva L3 puffstage 3-6  (648) larva L3 puffstage 7-9  (614) white prepupae new  (689) white prepupae 12hr  (795) white prepupae 24hr  (1077) pupae 2d postWPP  (529) pupae 3d postWPP  (251) pupae 4d postWPP  (299) adult male 01day  (357) adult male 05day  (407) adult male 30day  (440) adult female 01day  (703) adult female 05day  (772) adult female 30day  (829) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  1829 embryo 02-04hr  (3762) embryo 04-06hr  (3634) embryo 06-08hr  (2510) embryo 08-10hr  1954 embryo 10-12hr    1375 embryo 12-14hr    996 embryo 14-16hr    1196 embryo 16-18hr    694 embryo 18-20hr    484 embryo 20-22hr    468 embryo 22-24hr    422 larva L1    642 larva L2    545 larva L3 12hr old    471 larva L3 puffstage 1-2    431 larva L3 puffstage 3-6    648 larva L3 puffstage 7-9    614 white prepupae new    689 white prepupae 12hr    795 white prepupae 24hr    1077 pupae 2d postWPP    529 pupae 3d postWPP    251 pupae 4d postWPP    299 adult male 01day    357 adult male 05day    407 adult male 30day    440 adult female 01day    703 adult female 05day    772 adult female 30day    829 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1829 embryo 02-04hr    3762 embryo 04-06hr    3634 embryo 06-08hr    2510 embryo 08-10hr    1954 embryo 10-12hr    1375 embryo 12-14hr    996 embryo 14-16hr    1196 embryo 16-18hr    694 embryo 18-20hr    484 embryo 20-22hr    468 embryo 22-24hr    422 larva L1    642 larva L2    545 larva L3 12hr old    471 larva L3 puffstage 1-2    431 larva L3 puffstage 3-6    648 larva L3 puffstage 7-9    614 white prepupae new    689 white prepupae 12hr    795 white prepupae 24hr    1077 pupae 2d postWPP    529 pupae 3d postWPP    251 pupae 4d postWPP    299 adult male 01day    357 adult male 05day    407 adult male 30day    440 adult female 01day    703 adult female 05day    772 adult female 30day    829 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1829 embryo 02-04hr    3762 embryo 04-06hr    3634 embryo 06-08hr    2510 embryo 08-10hr    1954 embryo 10-12hr    1375 embryo 12-14hr    996 embryo 14-16hr    1196 embryo 16-18hr    694 embryo 18-20hr    484 embryo 20-22hr    468 embryo 22-24hr    422 larva L1    642 larva L2    545 larva L3 12hr old    471 larva L3 puffstage 1-2    431 larva L3 puffstage 3-6    648 larva L3 puffstage 7-9    614 white prepupae new    689 white prepupae 12hr    795 white prepupae 24hr    1077 pupae 2d postWPP    529 pupae 3d postWPP    251 pupae 4d postWPP    299 adult male 01day    357 adult male 05day    407 adult male 30day    440 adult female 01day    703 adult female 05day    772 adult female 30day    829 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0003977    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0003977 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0003977 expression level Tissue   Expression Level Larval Central Nervous System    84.475 Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    76.1 Larval Trachea no informative data Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    61.1 Adult Testis no informative data Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    84.475 Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    76.1 Larval Trachea no informative data Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    61.1 Adult Testis no informative data Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    84.475 Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    76.1 Larval Trachea no informative data Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    61.1 Adult Testis no informative data Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    84.475 Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    76.1 Larval Trachea no informative data Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    61.1 Adult Testis no informative data Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0003977 expression level Tissue   Expression Level Larval Central Nervous System    84.475 Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    76.1 Larval Trachea no informative data Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    61.1 Adult Testis no informative data Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    84.475 Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    76.1 Larval Trachea no informative data Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    61.1 Adult Testis no informative data Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    84.475 Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    76.1 Larval Trachea no informative data Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    61.1 Adult Testis no informative data Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    84.475 Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    76.1 Larval Trachea no informative data Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    61.1 Adult Testis no informative data Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland     Larval Trachea no informative data Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary     Adult Testis no informative data Adult Male Accessory Gland no informative data Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    no informative data   NA  Eye    no informative data   NA  Brain    no informative data   84.475  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    no informative data   NA  Crop    no informative data   no informative data  Midgut    no informative data   no informative data  Hindgut    no informative data   no informative data  Malpighian Tubules    no informative data   no informative data  Fat Body    no informative data   76.1  Salivary Gland    no informative data   NA  Heart    no informative data   no informative data  Trachea    NA   NA  VirginFemale Spermatheca    no informative data   NA  InseminatedFemale Spermatheca    no informative data   NA  Ovary    61.1   NA  Testis    no informative data   NA  Male Accessory Gland    no informative data   no informative data  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_17
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003977 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3496-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal vir3 lethal | female vir2f lethal | female | larval stage vir2f vir3 vir4 vir5 vir6 vir7 lethal | female | maternal effect | recessive vir6 lethal | female | recessive vir2f lethal | maternal effect | recessive vir3 vir4 lethal | recessive vir3 vir4 vir22 vir23 semi-lethal | male | recessive vir6 viable vir2f virts viable, with Scer\GAL4pnr-MD237 virGD10988 viable | male vir2f Sterility Allele female sterile vir250 male fertile vir2f Other Phenotypes Allele sex-determination defective | female | heat sensitive virts sex-determination defective | recessive | heat sensitive virts visible, with Scer\GAL4pnr-MD237 virGD10988 wild-type vir+t10 Phenotype manifest in Allele abdominal tergite 6 | heat sensitive virts abdominal tergite 7 | heat sensitive virts adult abdomen | heat sensitive virts anal plate | heat sensitive virts border follicle cell | somatic clone virPBac79 chaeta | supernumerary, with Scer\GAL4pnr-MD237 virGD10988 female gonopod | heat sensitive virts hypoproct | heat sensitive virts mesothoracic tergum, with Scer\GAL4pnr-MD237 virGD10988 oviprotector | heat sensitive virts trichogen cell, with Scer\GAL4pnr-MD237 virGD10988
Classical Alleles ( 13 )
For All Classical Alleles Show
Allele of vir Class Mutagen Stocks Known lesion vir22 diepoxybutane X ray 0 Yes vir23 diepoxybutane X ray 0 Yes vir250 ethyl methanesulfonate 0 -- vir2f ethyl methanesulfonate 0 Yes vir3 ethyl methanesulfonate 0 -- vir4 ethyl methanesulfonate 0 Yes vir5 ethyl methanesulfonate 0 -- vir6 ethyl methanesulfonate 0 -- vir7 ethyl methanesulfonate 0 -- virH2 ethyl methanesulfonate 0 -- virPBac79 piggyBac transposase 0 Yes virts ethyl methanesulfonate 0 Yes virunspecified 0 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of vir Class Mutagen Stocks Known lesion virGD10988 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes vir+t10 in vitro construct - genomic fragment 0 Yes virTub.T:Zzzz\His6 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)bw-S46 (Niessen et al., 2001, Hilfiker and Nothiger, 1991, Nothiger, 1994.12.23) Df(2R)Exel7178 (Ryder, 2004.4.26) Df(2R)or-BR6 (Burnette et al., 1999) Df(2R)vir130 (Schutt et al., 1998, Hilfiker et al., 1995) Df(2R)vir15 (Niessen et al., 2001)
Not disrupted in	Df(2R)bw-HB132 (Niessen et al., 2001)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD10988} NA characterization construct P{vir+t10} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{IRES-GFP.GT}virPBac79 NA
Gene Ontology: Function, Process & Cellular Component ( 9 unique terms )
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
border follicle cell migration inferred from mutant phenotype (Mathieu et al., 2007) RNA splicing, via transesterification reactions inferred from mutant phenotype (assigned by UniProtKB) (Burnette et al., 1999)
Cellular Component
CV term Evidence References
nucleus inferred from direct assay AND inferred from sequence or structural similarity (Niessen et al., 2001)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
nucleic acid binding inferred from sequence or structural similarity with EMBL:AF046043 AND inferred from sequence or structural similarity with EMBL:X76060 (Niessen et al., 2001)
Biological Process
CV term Evidence References
dosage compensation traceable author statement (Niessen et al., 2001) primary sex determination, soma non-traceable author statement (Schutt and Nothiger, 2000) regulation of nuclear mRNA splicing, via spliceosome traceable author statement (Niessen et al., 2001) sex determination traceable author statement (Niessen et al., 2001)
Cellular Component
CV term Evidence References
integral to membrane inferred from sequence or structural similarity (Niessen et al., 2001)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions vir allele Gene References vir2f mle (Hilfiker et al., 1995) msl-1 (Hilfiker et al., 1995) msl-2 (Hilfiker et al., 1995) snf (Cline et al., 1999) Sxl (Hilfiker et al., 1995, Cline et al., 1999, Niessen et al., 2001) vir3 Ubx (Burnette et al., 1999) vir6 Sxl (Schutt et al., 1998, Bopp et al., 1999) vir22 Sxl (Niessen et al., 2001) vir23 Sxl (Niessen et al., 2001) virunspecified Sxl (Hilfiker et al., 1995)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 71017 DroID - A comprehensive database of gene and protein interactions. • FBgn0003977 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 47869
Orthologs
Genome-wide drosophilid orthologs	Dana\GF11771 Dere\GG20042 Dgri\GH21217 Dmoj\GI20503 Dper\GL10646 Dpse\GA17481 Dsec\GM15555 Dsim\GD25058 Dvir\GJ22353 Dwil\GK23286 Dyak\GE11577
Curated drosophilid orthologs	Dpse\GA17481
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL009878-PA Aedes aegypti (mosquito) AGAP000332-PA Anopheles gambiae (mosquito) XP_395082.3 Apis mellifera (honey bee) XP_001949482.1 Acyrthosiphon pisum (pea aphid) 128950 Branchiostoma floridae (lancelet) BGIBMGA011914-PA Bombyx mori (silk worm) ENSBTAP00000004929 Bos taurus (bovine) ENSCAFP00000013612 Canis familiaris (dog) CPIJ014261 Culex pipens (mosquito) ENSCPOP00000008375 Cavia porcellus (guinea pig) ENSCSAVP00000003501 Ciona savignyi (sedentary tunicate) 299751 Daphnia pulex (daphnia) ENSECAP00000010878 Equus caballus (horse) ENSGACP00000012082 Gymnopilus aculeatus (mushroom) ENSGALP00000025680 Gallus gallus (chicken) 161283 Hypsipyla robusta (cedar shoot borer) ENSP00000297591 Homo sapiens (human) ISCW003838-PA Ixodes scapularis (deer tick) 234825 Lottia gigantea (owl limpet) ENSMODP00000034615 Monodelphis domestica (gray opossum) ENSMMUP00000017043 Macaca mulatta (rhesus monkey) ENSMUSP00000103943 Mus musculus (house mouse) 205936 Nematostella vectensis (starlet anemone) XP_001606740.1 Nasonia vitripennis (wasp) ENSOANP00000017999 Ornithorynchus anatinus (platypus) PHUM000345-PA Pediculus humanus (human body louse) ENSPPYP00000021033 Pongo pygmaeus (orangutan) ENSPTRP00000034935 Pan troglodytes (chimpanzee) ENSRNOP00000020021 Rattus norvegicus (norway rat) Smp_153720 Schistosoma mansoni (trematode parasite) XP_785662.2 Strongylocentrotus purpuratus (purple sea urchin) XP_001807277.1 Tribolium castaneum (red flour beetle) ENSTNIP00000021537 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000023945 Takifugu rubripes (pufferfish Takifugu) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • ISCW003838 FBgn0229377 FBgn0225248 FBgn0209466 FBgn0196370 FBgn0170473 JGI_V11_299751 FBgn0077492 FBgn0148256 FBgn0143239 FBgn0128679 FBgn0112241 FBgn0100399 FBgn0100389 FBgn0099746 FBgn0099688 FBgn0099687 FBgn0090965 FBgn0090959 FBgn0088811 CPIJ014261 BGIBMGA011914 ACYPI002647 AGAP000332 AAEL009878 PHUM182310 GLEAN_02713
Stocks & Reagents
Stocks Listed in FlyBase ( 2 )
VDRC	v43768 w1118 P{GD10988}v43768 v43769 w1118; P{GD10988}v43769
Genomic Clones ( 1 )
	BACR04G19 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 12 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LD17224 LD41729
Other clones	18047 59779 75052 214569.57 EK186332 EK204850 EK290105 EN07109 EP10754 UT01040
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0003977 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 47869
Antibody Information
Other Information
Discoverer
	Schupbach.
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: vir CG3496 (Niessen et al., 2001, FlyBase, 1996-)
Additional comments	Source for merge of vir CG3496 was sequence comparison (date:010307). (FlyBase, 1996-)
Other Comments
	vir and fl(2)d are required for inclusion of mI and mII microexons in Ubx mRNAs. (Burnette et al., 1999) vir is a complex locus harbouring female-specific functions that are required for sex determination and dosage compensation as well as functions that are zygotically required for viability in both sexes. Genetic and molecular analyses suggest that vir is required for female-specific splicing of Sxl and of tra pre-mRNA. (Hilfiker et al., 1995) vir is necessary for female-specific expression of Sxl as well as for vital processes unrelated to sex. (Niessen et al., 1995) vir is involved in sex determination and a mutant has been isolated that rescues the male lethality of snf1 SxlM1 individuals. (Albrecht and Salz, 1994)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_080161 RefSeq (Proteins) • NP_524900 DDBJ / EMBL / GenBank • AAF46988 AAK12372 AF281363 Entrez Gene - A searchable database of RefSeq genes. • 47869 UniProtKB/TrEMBL • Q9W1R5
Other Crossreferences
Linkouts
	BioGRID - A database of protein and genetic interactions • 71017 DroID - A comprehensive database of gene and protein interactions. • FBgn0003977 DRSC - Results from RNAi screens. • FBgn0003977 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003977 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3496-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0003977 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 47869 InParanoid A subset of ortholog calls from InParanoid. • AAEL009878-PA Aedes aegypti (mosquito) AGAP000332-PA Anopheles gambiae (mosquito) XP_395082.3 Apis mellifera (honey bee) XP_001949482.1 Acyrthosiphon pisum (pea aphid) 128950 Branchiostoma floridae (lancelet) BGIBMGA011914-PA Bombyx mori (silk worm) ENSBTAP00000004929 Bos taurus (bovine) ENSCAFP00000013612 Canis familiaris (dog) CPIJ014261 Culex pipens (mosquito) ENSCPOP00000008375 Cavia porcellus (guinea pig) ENSCSAVP00000003501 Ciona savignyi (sedentary tunicate) 299751 Daphnia pulex (daphnia) ENSECAP00000010878 Equus caballus (horse) ENSGACP00000012082 Gymnopilus aculeatus (mushroom) ENSGALP00000025680 Gallus gallus (chicken) 161283 Hypsipyla robusta (cedar shoot borer) ENSP00000297591 Homo sapiens (human) ISCW003838-PA Ixodes scapularis (deer tick) 234825 Lottia gigantea (owl limpet) ENSMODP00000034615 Monodelphis domestica (gray opossum) ENSMMUP00000017043 Macaca mulatta (rhesus monkey) ENSMUSP00000103943 Mus musculus (house mouse) 205936 Nematostella vectensis (starlet anemone) XP_001606740.1 Nasonia vitripennis (wasp) ENSOANP00000017999 Ornithorynchus anatinus (platypus) PHUM000345-PA Pediculus humanus (human body louse) ENSPPYP00000021033 Pongo pygmaeus (orangutan) ENSPTRP00000034935 Pan troglodytes (chimpanzee) ENSRNOP00000020021 Rattus norvegicus (norway rat) Smp_153720 Schistosoma mansoni (trematode parasite) XP_785662.2 Strongylocentrotus purpuratus (purple sea urchin) XP_001807277.1 Tribolium castaneum (red flour beetle) ENSTNIP00000021537 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000023945 Takifugu rubripes (pufferfish Takifugu) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /dbzhnsky/viriliz1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 47869 modMine - Data generated by the modENCODE project. • FBgn0003977 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • ISCW003838 FBgn0229377 FBgn0225248 FBgn0209466 FBgn0196370 FBgn0170473 JGI_V11_299751 FBgn0077492 FBgn0148256 FBgn0143239 FBgn0128679 FBgn0112241 FBgn0100399 FBgn0100389 FBgn0099746 FBgn0099688 FBgn0099687 FBgn0090965 FBgn0090959 FBgn0088811 CPIJ014261 BGIBMGA011914 ACYPI002647 AGAP000332 AAEL009878 PHUM182310 GLEAN_02713
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	CG3496   vir   Vir (Anholt and Williams, 2010)
Name Synonym	virilizer (Mathieu et al., 2007)
Secondary FlyBase IDs
	FBgn0034852
References ( 39 )
Generate a list of	All references relating to this gene ( 39 )
List References by type	Research paper  ( 15 ) Supplementary material  ( 3 ) Review  ( 5 ) Erratum  ( 1 ) Personal communication to FlyBase  ( 3 ) Abstract  ( 8 ) FlyBase analysis  ( 1 ) Book  ( 1 ) Computer file  ( 1 ) DNA/RNA sequence record  ( 1 )
Recent research papers ( 1 )
	Anholt and Williams, 2010, Chem. Senses 35(1): 21--30 The soluble proteome of the Drosophila antenna. [FBrf0209552] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...