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General Information
Symbol
Dmel\vn
Species
D. melanogaster
Name
vein
Annotation Symbol
CG10491
Feature Type
FlyBase ID
FBgn0003984
Gene Model Status
Stock Availability
Gene Snapshot
vein (vn) encodes a secreted neuregulin-like EGFR ligand. It has weaker intrinsic activity, and a lower receptor affinity, than the TGFalpha-like ligand encoded by spi. It has roles in growth and patterning of tissues including muscle, midgut, ovary, trachea, glia, eye, leg, and wing. [Date last reviewed: 2019-03-21]
Also Known As
CT29452, ddd
Key Links
Genomic Location
Cytogenetic map
Sequence location
3L:5,813,338..5,845,664 [-]
Recombination map
3-15
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
-
Summaries
Pathway (FlyBase)
Epidermal Growth Factor Receptor Signaling Pathway Core Components -
The Epidermal Growth Factor Receptor (EGFR) signaling pathway is used multiple times during development (FBrf0190321). It is activated by the binding of a secreted ligand to the receptor tyrosine kinase Egfr and acts via the canonical Ras/Raf/MAP kinase (ERK) cascade. (Adapted from FBrf0190321 and FBrf0221727).
Gene Group (FlyBase)
EGFR AGONISTS -
Epidermal Growth Factor Receptor (EGFR) agonists are secreted ligands that activate the Egfr receptor tyrosine kinase.
Protein Function (UniProtKB)
Ligand for the EGF receptor. Seems to play a role in the global proliferation of wing disc cells and the larval patterning. Shows a strong synergistic genetic interaction with spi, suggesting a molecular interdependence. Required for the development of interveins cells.
(UniProt, Q94918)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
ddd: defective dorsal discs (A. Shearn)
Homozygous larvae perish between the first larval instar and the prepupal stage; dorsal thoracic imaginal discs, i.e. of the pronotum, mesonotum, and metanotum reduced to 3% or less of normal size; all other imaginal discs develop normally. Mutant larvae support the growth of wild-type wing discs; mutant wing discs show very little development in wild-type larval. Mutant cells develop normally in wing discs that contain mixtures of mutant and wild-type cells, as produced by nuclear or cellular transplantation into blastoderms or by somatic exchange. Mutant leg discs transplanted into wild-type hosts can transdetermine to wing development. Studies of temperature-sensitive genotypes indicate that ddd+ product is not required for normal wing development during embryogenesis. No evidence for a maternal effect in either conditional mutants raised under permissive conditions and switched to restrictive temperatures or in germ-line-transplants of mutant cells into wild-type hosts.
vn: vein
thumb
vn: vein
Right wing of vn (Puro, 1982)
Large section of vein L4 and anterior crossvein missing. Posterior crossvein often incomplete; gap sometimes present in L3. Male sterile, female fertile.
*Vn: Vein
Vein L4 not complete. Wings slightly spread. Fly smaller than normal. Homozygous lethal. RK2A.
Summary (Interactive Fly)
a secreted neuregulin-like EGFR ligand - EGF domain and Ig domain - an intrinsically weaker ligand for EGF-receptor than Spitz - Vein is the major ligand for activating EGF-R in intervein regions - has roles in growth and patterning of tissues including muscle, midgut, ovary, trachea, glia, eye and leg .
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
2

Please see the GBrowse view of Dmel\vn or the JBrowse view of Dmel\vn for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.45
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0077082
5102
623
FBtr0300010
4059
618
Additional Transcript Data and Comments
Reported size (kB)
6.8, 5 (northern blot)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0076790
71.7
623
10.41
FBpp0289287
71.1
618
10.31
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
622, 621 (aa); 70 (kD observed); 71 (kD predicted)
Comments
vn proteins have a number of features that suggest function. They have a signal sequence, a PEST domain, an Ig-like domain, and an EGF-like domain. vn protein was shown to be a secreted. The vn antibody recognizes both proteins.
External Data
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\vn using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (23 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
inferred from direct assay
inferred from mutant phenotype
(assigned by UniProt )
inferred from direct assay
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000873337
(assigned by GO_Central )
Biological Process (17 terms)
Terms Based on Experimental Evidence (16 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from mutant phenotype
inferred from direct assay
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:rl; FB:FBgn0003256, FLYBASE:Egfr; FB:FBgn0003731
inferred from genetic interaction with FLYBASE:Sulf1; FB:FBgn0040271
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000873337
(assigned by GO_Central )
Cellular Component (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
inferred from direct assay
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
non-traceable author statement
(assigned by UniProt )
inferred from biological aspect of ancestor with PANTHER:PTN000873337
(assigned by GO_Central )
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
In the wing pouch, vn is expressed as a broad discontinuous stripe straddling the A/P boundary in the L3 and L4 intervein region and also in the hinge and the notum. No transcript is observed in the haltere disc.
Transcripts are detected in pioneer MP2 neurons in the CNS, first appearing at stage 11 and persisting at least through stage 14. Transcript is detected in the dMP2 neurons throughout this time, however, expression in the vMP2 neuron only persists through stage 12 in many cases. Transcript is also detected in VUMs and two more cells in each hemisegment.
vn transcripts are expressed inblastoderm embryos in two ventrolateral stripes that come to the midlineas gastrulation proceeds. Expression persists in the midline but isincreasingly restricted to single cells. Expression is seen in the CNS andepidermis at germ band retraction. vn is also expressed in theamnioserosa precursors in the blastoderm and in the amnioserosa properuntil the end of germ band extension. Late in germ band extension,expression is seen in some PNS precursors which include Keilin's organprecursors and a subset of cells of the chordotonal organs. vn is alsoexpressed in the head throughout development; in the clypeolabrum, themaxillary and labial lobes and around the stomodeum. In late embryos,expression occurs in the segmental muscles and gut wall. Transientexpression is observed in the tracheal pits at stage 10.
vn transcripts are expressed in a complex and dynamic pattern in the wing, haltere, leg and eye-antenna discs. The pattern in the wing is described in detail. vn transcripts are first expressed in the presumptive notum and then in the wing pouch and hinge regions. Later, transcripts localize to intervein regions. This begins as a stripe of expression stradling the AP boundary in late larval discs and develops into all intervein regions after puparium formation.
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
vn protein expression in embryonic somatic muscle precursor cells colocalizes with Kr protein expression.
Marker for
Subcellular Localization
CV Term
Evidence
References
inferred from direct assay
Expression Deduced from Reporters
Reporter: P{GawB}vnGAL4
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{PZ}vn10567
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{PZ}vnrF264
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{vn.497-lacZ}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{vn-GAL4.R}
Stage
Tissue/Position (including subcellular localization)
Reference
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\vn in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 48 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 21 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of vn
Transgenic constructs containing regulatory region of vn
Deletions and Duplications ( 13 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
adult cuticle & head capsule | dorsal
border follicle cell & filopodium, with Scer\GAL4slbo.2.6
dorsal mesothoracic disc & peripodial epithelium | somatic clone, with Scer\GAL4αTub84B.PL
dorsal mesothoracic disc & peripodial epithelium | somatic clone | cell non-autonomous, with Scer\GAL4αTub84B.PL
sensory neuron & axon & embryo
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (5)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
4 of 15
Yes
Yes
2 of 15
No
Yes
2 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (4)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
5 of 15
Yes
Yes
2 of 15
No
Yes
2 of 15
No
Yes
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (4)
2 of 13
Yes
Yes
2 of 13
Yes
Yes
2 of 13
Yes
Yes
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (1)
1 of 12
Yes
Yes
Danio rerio (Zebrafish) (4)
4 of 15
Yes
Yes
3 of 15
No
Yes
3 of 15
No
Yes
2 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (0)
No records found.
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091907S7 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Drosophila suzukii
Spotted wing Drosophila
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091508D3 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( None identified )
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( None identified )
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
No non-Arthropod Metazoa orthologies identified
Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (0)
No records found.
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser

    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    RNA-protein
    Physical Interaction
    Assay
    References
    RNA-RNA
    Physical Interaction
    Assay
    References
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement

    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    suppressible
    suppressible
    suppressible
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    suppressible
    External Data
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Gene Group - Pathway Membership (FlyBase)
    Epidermal Growth Factor Receptor Signaling Pathway Core Components -
    The Epidermal Growth Factor Receptor (EGFR) signaling pathway is used multiple times during development (FBrf0190321). It is activated by the binding of a secreted ligand to the receptor tyrosine kinase Egfr and acts via the canonical Ras/Raf/MAP kinase (ERK) cascade. (Adapted from FBrf0190321 and FBrf0221727).
    External Data
    Linkouts
    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3L
    Recombination map
    3-15
    Cytogenetic map
    Sequence location
    3L:5,813,338..5,845,664 [-]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    64E12-64F2
    Limits computationally determined from genome sequence between P{PZ}Bre101640 and P{PZ}vn10567
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    64F1-64F3
    (determined by in situ hybridisation)
    64C13-65A15
    64F-64F
    (determined by in situ hybridisation)
    Experimentally Determined Recombination Data
    Location
    3-18.0 +/- 1.9
    3-16.2
    Left of (cM)
    Right of (cM)
    Notes
    3-18.0 based on vn allele.
    Stocks and Reagents
    Stocks (23)
    Genomic Clones (31)
    cDNA Clones (51)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequences
    BDGP DGC clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    BDGP DGC clones
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Antibody Information
    Laboratory Generated Antibodies
     
    Commercially Available Antibodies
     
    Other Information
    Relationship to Other Genes
    Source for database identify of
    Source for identity of: vn CG10491
    Source for database merge of
    Additional comments
    Vein-dominant1 (previously 'Vn[1]') may be a dominant negative allele of vn, because expressing vn without the EGF domain gives a vein loss phenotype. So Vein-dominant (previously 'Vn') and vn may refer to the same gene.
    Map position and phenotype suggest of "vn1" suggests a possible relationship to "Vn1", but allelism has not been tested as "Vn1" is no longer available.
    Six alleles (Diaz-Benjumea et al., 1989). Not tested for allelism with Vn, a dominant mutant of similar map position and phenotype which has been lost.
    Other Comments
    rho, sim and vn are required for the formation of the brain lateral to the foregut cells.
    The vn/Egfr pathway may be directly required for development of the notum by activating notum specifying genes and indirectly controlling wing outgrowth through regulation of ap.
    hh activates vn expression. This activation is mediated through the gene ci.
    vn is required for the development of some, but not all, of the hh-dependent medial head structures.
    vn has a minor role in the embryo and does not induce Egfr target genes such as argos and pnt in the embryo. vn has a major role in wing development and vn/Egfr signal is a potent inducer of Egfr target genes in the wing disc.
    EGF domain swapping experiments of vn, spi and argos demonstrate that the EGF domain is the key determinant that gives Egfr inhibitors and activators their distinct properties.
    vn is the activating ligand of Egfr in the midgut. vn plays a permissive role in the induction of the endoderm by dpp and wg, which in turn up-regulate vn expression in the midgut mesoderm in two regions overlapping the dpp sources.
    vn plays a role in autocrine Egfr signaling.
    vn is required to complement spi in the development of a subset of muscle precursors whose differentiation depends on Egfr activity.
    Genetic combinations with mutants of nub cause additive phenotypes.
    A screen to isolate mutations that cause dominant enhancement of wing vein phenotypes associated with Egfr recovered mutations in vn.
    In vivo culture of mutant discs from genotypes that are normally embryonic lethal demonstrates vn is essential for wing disc growth.
    The molecular signal for terminal differentiation of tendon cells is secreted vn protein produced by the myotubes.
    Loss of function mutations in bs are epistatic to loss of function mutations in rho or vn.
    Molecular and genetic data suggest that vn is linked to the Egfr pathway and encodes a ligand for the Egfr product.
    Phenotype and expression analysis show vn has an early role in global proliferation of the wing disc and specific roles in the development of the notum, hinge, longitudinal vein 4 and all intervein regions.
    Mutant embryos have a phenotype similar to that seen in sr, with abnormal direction of myotubule filopodia.
    Phenotypic analysis suggests vn is a new member of the spi group.
    Meiotic location, larval phenotype, clonal behaviour, complementation tests and vn heteroallelic combinations suggest vn and vn are allelic.
    Genetic mosaics demonstrate that cell proliferation is reduced in all regions of the wing blade in a local autonomous way, the effects are more extreme when clones occupy intervein regions bordering veins. Clones also have nonautonomous effects in the proliferation of wild type cells in the same wing, these effects are more extreme in double mutants with rho.
    Mutations in vn cause pleiotropic phenotypes in embryonic patterns and affect several longitudinal veins.
    ve, vn, ci, cg, svs, ast, H, Vno and vvl belong to the vein phenotypic group (Puro, 1982, Droso. Info. Serv. 58:205--208 ) within the 'lack-of-vein' mutant class. Loss-of-function alleles at these loci remove stretches of veins in two or more longitudinal veins. Double mutations within members of this group remove all veins, have smaller, slightly lanceolate wings, no sensilla and extra chaetae. Some alleles are embryonic lethal.
    Homozygous ddd larvae perish between the first larval instar and the prepupal stage; dorsal thoracic imaginal discs, i.e. of the pronotum, mesonotum and metanotum reduced to 3% or less of normal size; all other imaginal discs develop normally. Mutant larvae support the growth of wild-type wing discs; mutant wing discs show very little development in wild-type larval. Mutant cells develop normally in wing discs that contain mixtures of mutant and wild-type cells, as produced by nuclear or cellular transplantation into blastoderms or by somatic exchange. Mutant leg discs transplanted into wild-type hosts can transdetermine to wing development. Studies of temperature-sensitive genotypes indicate that vn+ product is not required for normal wing development during embryogenesis. No evidence for a maternal effect in either conditional mutants raised under permissive conditions and switched to restrictive temperatures or in germ-line-transplants of mutant cells into wild-type hosts.
    Origin and Etymology
    Discoverer
    Puro, 1960.
    Etymology
    Identification
    External Crossreferences and Linkouts ( 63 )
    Sequence Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
    Other crossreferences
    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    Flygut - An atlas of the Drosophila adult midgut
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    KEGG Genes - Molecular building blocks of life in the genomic space.
    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
    modMine - A data warehouse for the modENCODE project
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    DRSC - Results frm RNAi screens
    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    FlyMine - An integrated database for Drosophila genomics
    Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Synonyms and Secondary IDs (19)
    Reported As
    Symbol Synonym
    l(3)10567
    l(3)10568
    l(3)ddd
    l(3)rF264
    l(3)vn10567
    vn
    (Chai et al., 2019, Campbell et al., 2018, Powers and Srivastava, 2018, Rogers et al., 2017, Takemura and Nakato, 2017, Transgenic RNAi Project members, 2017-, Carbone et al., 2016, Jussen et al., 2016, Liu et al., 2016, Nagel et al., 2016, Gene Disruption Project members, 2015-, Kim et al., 2015, Lim et al., 2015, Rao et al., 2015, Ashwal-Fluss et al., 2014, Austin et al., 2014, Kux and Pitsouli, 2014, Liang et al., 2014, Li et al., 2014, Okumura et al., 2014, Scopelliti et al., 2014, Simcox, 2014.9.25, Valentine et al., 2014, Curtis et al., 2013, Garcia et al., 2013, Hong et al., 2013, Markstein, 2013, Ozkan et al., 2013, Ozkan et al., 2013, Paul et al., 2013, Saunders et al., 2013, Butchar et al., 2012, Chakrabarti et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Maeng et al., 2012, Poernbacher et al., 2012, Ajuria et al., 2011, Hogan et al., 2011, Hwang and Rulifson, 2011, Jiang et al., 2011, Liu and Geisbrecht, 2011, Moses et al., 2011, Murillo-Maldonado et al., 2011, Ozdemir et al., 2011, Sinenko et al., 2011, Slattery et al., 2011, Takemura and Adachi-Yamada, 2011, Wang et al., 2011, Bosch et al., 2010, Foley et al., 2010, Klein et al., 2010, Rendina et al., 2010, Grieder et al., 2009, Huh et al., 2009, Jiang and Edgar, 2009, Oishi et al., 2009, Terriente-Félix and de Celis, 2009, Zhang et al., 2009, Christensen et al., 2008.4.15, Christensen et al., 2008.4.15, Christensen et al., 2008.4.15, Rafel and Milán, 2008, Beltran et al., 2007, Muse et al., 2007, Sandmann et al., 2007, Zeitlinger et al., 2007, Charroux et al., 2006, Choksi et al., 2006, Guichard et al., 2006, Oishi et al., 2006, Parker, 2006, Ramos and Mohler, 2006, Zinzen et al., 2006, Galindo et al., 2005, Macdonald and Long, 2005, Stathopoulos and Levine, 2005, Angulo et al., 2004, Markstein et al., 2004, Schlesinger et al., 2004, Chang et al., 2003, Chang et al., 2001)
    wvn
    Secondary FlyBase IDs
    • FBgn0001609
    • FBgn0002436
    • FBgn0010946
    • FBgn0011493
    Datasets (0)
    Study focus (0)
    Experimental Role
    Project
    Project Type
    Title
    References (390)