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Gene Dmel\vn

General Information
Symbol	Dmel\vn	Species	D. melanogaster
Name	vein	Annotation symbol	CG10491
Feature type	protein_coding_gene	FlyBase ID	FBgn0003984
Gene Model Status	Current	Stock availability	14 publicly available
Also Known As	vein, CT29452
Genomic Location
Chromosome (arm)	3L	Recombination map	3-16.2
Cytogenetic map	64E12-64F2	Sequence location	3L:5,806,438..5,838,764 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene vein is referred to in FlyBase by the symbol Dmel\vn (CG10491, FBgn0003984). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: epidermal growth factor receptor binding. There is experimental evidence for 12 unique biological process terms, many of which group under: anatomical structure development; organ development; biological regulation; post-embryonic appendage morphogenesis; regulation of biological process; post-embryonic organ morphogenesis; positive regulation of cell proliferation; cellular component organization or biogenesis; cellular process involved in reproduction; notum cell fate specification; cell projection organization; central nervous system development; digestive tract development. 61 alleles are reported. The phenotypes of these alleles are annotated with: organ system subdivision; adult segment; organ system; nervous system; adult mesothoracic segment; sensillum; midgut constriction; multi-cell-component structure; primordium; dorsal thoracic disc. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: EGF-like region, conserved site; Epidermal growth factor-like; Epidermal growth factor-like, type 3; Immunoglobulin I-set; Immunoglobulin subtype 2; Immunoglobulin-like; Immunoglobulin-like fold. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of very low expression. Peak expression observed at stages throughout embryogenesis, during late pupal stages. Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1634520_at completely aligns to an exonic region of only a subset of 1 of the 2 FlyBase-annotated transcript isoforms of vn. Gene sequence location is 3L:5806438..5838764.
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	ddd: defective dorsal discs (A. Shearn) Homozygous larvae perish between the first larval instar and the prepupal stage; dorsal thoracic imaginal discs, i.e. of the pronotum, mesonotum, and metanotum reduced to 3% or less of normal size; all other imaginal discs develop normally. Mutant larvae support the growth of wild-type wing discs; mutant wing discs show very little development in wild-type larval. Mutant cells develop normally in wing discs that contain mixtures of mutant and wild-type cells, as produced by nuclear or cellular transplantation into blastoderms or by somatic exchange. Mutant leg discs transplanted into wild-type hosts can transdetermine to wing development. Studies of temperature-sensitive genotypes indicate that ddd+ product is not required for normal wing development during embryogenesis. No evidence for a maternal effect in either conditional mutants raised under permissive conditions and switched to restrictive temperatures or in germ-line-transplants of mutant cells into wild-type hosts. vn: vein vn: vein Right wing of vn (Puro, 1982) Large section of vein L4 and anterior crossvein missing. Posterior crossvein often incomplete; gap sometimes present in L3. Male sterile, female fertile. *Vn: Vein Vein L4 not complete. Wings slightly spread. Fly smaller than normal. Homozygous lethal. RK2A.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10
FB2012_01	References Wang et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(27): 11139--11144 Casso et al., 2011, Genetics 187(2): 485--499 Ozdemir et al., 2011, Genome Res. 21(4): 566--577 Sequence features BKN51013 HFA11408 BKN28432 BKN50021
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 64E12-64F2   Limits computationally determined from genome sequence between P{PZ}Bre101640 and P{PZ}vn10567
Experimentally Determined Cytological Location
Cytogenetic map Notes References 64F-64F     (Schnepp, 1996.8.26) 64F1-64F3   (determined by in situ hybridisation)   (Spradling et al., 1999) 64C13-65A15     (Price et al., 1997) 64F-64F   (determined by in situ hybridisation)   (Simcox et al., 1996) 64F-64F   (determined by in situ hybridisation)   (Volk, 1996.5.12) 64F-64F   (determined by in situ hybridisation)   (Simcox, 1994) 64F-64F   (determined by in situ hybridisation)   (Shearn, 1990) 64F1-64F3     (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location	3-16.2   3-18.0 +/- 1.9 (Wurst et al., 1984) 3-19.5 (Price et al., 1997)
Left of (cM)
Right of (cM)
Notes	3-18.0 based on vn allele.
Gene Model & Products
Please see the GBrowse view of Dmel\vn for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) vn-RA FBtr0077082  NM_079218   5102   623 vn-RC FBtr0300010  NM_001014565   4059   618
Additional Transcript Data & Comments
Reported size (kB)	6.8, 5 (northern blot) (Schnepp et al., 1996)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein vn-PA   FBpp0076790   71.7   623   10.41     NP_523942   AAF50739 vn-PC   FBpp0289287   71.1   618   10.31     NP_001014565   AAX52759
Additional Polypeptide Data & Comments
Reported size (kDa)	622, 621 (aa); 70 (kD observed); 71 (kD predicted) (Schnepp et al., 1996)
Comments	vn proteins have a number of features that suggest function. They have a signal sequence, a PEST domain, an Ig-like domain, and an EGF-like domain. vn protein was shown to be a secreted. The vn antibody recognizes both proteins. (Schnepp et al., 1996)
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Epidermal growth factor-like, type 3 (IPR000742) Immunoglobulin subtype 2 (IPR003598) Immunoglobulin-like (IPR007110) EGF-like region, conserved site (IPR013032) Epidermal growth factor-like (IPR006210) Immunoglobulin-like fold (IPR013783) Immunoglobulin I-set (IPR013098)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014296 AAF50739   AE014296 AAX52759   AQ034078   AY863796   AY863797   AY863798   AY863799   AY863800   AY863801   AY863802   AY863803   AY863804   AY863805   AY863806   AY863807   AY863808   AY863809   AY863810   AY863811   AY863812   AY863813   AY863814   BT029281   BT066306   BT071823   BT083396   BT083397   CK661978   CO263159   CO272377   CO276089   CO287077   CO288173   CO289838   CO292560   CO305117   CO312590   CZ478996   CZ480937   CZ480938   EC058383   EC060339   EC069912   EC070040   EC074087   EC091151   EC196806   EC202450   EC220337   EC230587   EC231223   EC241102   EC249109   EL871041   EL871161   EL871281   EL871404   EL874692   EL874819   GH945839   GH946102   GH948598   GH949884   GH950763   GH954147   GH956205   GH957484   GH958268   GH958288   GH959856   GH960827   GH962062   GH965285   GH965997   GH966233   GH966960   GH968032   GH968423   GH972911   GH973154   GH974939   GH979268   GH979601   GH979645   GH982271   GH982702   U67935 AAC47293
UniProtKB/Swiss-Prot	Q94918
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage   ventral midline | restricted   (Schnepp et al., 1996) maxillary lobe   (Schnepp et al., 1996) epidermis   (Schnepp et al., 1996) labral segment   (Schnepp et al., 1996) central nervous system   (Schnepp et al., 1996) labial segment   (Schnepp et al., 1996) stomodeum   (Schnepp et al., 1996) embryonic stage 1 -- 11   amnioserosa   (Schnepp et al., 1996) blastoderm stage   organism | striped & ventro-lateral   (Schnepp et al., 1996) amnioserosa | precursor   (Schnepp et al., 1996) embryonic stage 9 -- 10   ventral ectoderm | restricted & segmentally repeated   (Wessells et al., 1999) Comment:1-2 cells/hemisegment ventral midline | restricted & segmentally repeated   (Wessells et al., 1999) Comment:1-2 cells/hemisegment mesoderm   (Wessells et al., 1999) embryonic stage 10   tracheal pit   (Schnepp et al., 1996) embryonic stage 10 -- 15   embryonic central brain | subset   (Page, 2003) embryonic foregut | anterior & dorsal & ventral   (Page, 2003) embryonic stage 11 -- 12   vMP2 neuron   (Swiss-Prot Project Members, 1998.12.15) embryonic stage 11 -- 14   dMP2 neuron   (Swiss-Prot Project Members, 1998.12.15) embryonic stage 11 -- 17   peripheral nervous system | restricted   (Schnepp et al., 1996) chordotonal organ   (Schnepp et al., 1996) Keilin's organ   (Schnepp et al., 1996) embryonic stage 12 -- 13   embryonic myoblast | subset   (Yarnitzky et al., 1998) embryonic stage 16   visceral muscle   (Schnepp et al., 1996) somatic muscle   (Schnepp et al., 1996) larval stage   eye-antennal disc   (Simcox et al., 1996) ventral thoracic disc   (Simcox et al., 1996) haltere disc   (Simcox et al., 1996) larval stage & pupal stage   wing disc | restricted   (Simcox et al., 1996) scutum | presumptive   (Simcox et al., 1996) pupal stage   wing cell   (Simcox et al., 1996)
Additional Descriptive Data
	vn transcripts are expressed in a complex and dynamic pattern in the wing, haltere, leg and eye-antenna discs. The pattern in the wing is described in detail. vn transcripts are first expressed in the presumptive notum and then in the wing pouch and hinge regions. Later, transcripts localize to intervein regions. This begins as a stripe of expression stradling the AP boundary in late larval discs and develops into all intervein regions after puparium formation. (Simcox et al., 1996) vn transcripts are expressed inblastoderm embryos in two ventrolateral stripes that come to the midlineas gastrulation proceeds. Expression persists in the midline but isincreasingly restricted to single cells. Expression is seen in the CNS andepidermis at germ band retraction. vn is also expressed in theamnioserosa precursors in the blastoderm and in the amnioserosa properuntil the end of germ band extension. Late in germ band extension,expression is seen in some PNS precursors which include Keilin's organprecursors and a subset of cells of the chordotonal organs. vn is alsoexpressed in the head throughout development; in the clypeolabrum, themaxillary and labial lobes and around the stomodeum. In late embryos,expression occurs in the segmental muscles and gut wall. Transientexpression is observed in the tracheal pits at stage 10. (Schnepp et al., 1996) Transcripts are detected in pioneer MP2 neurons in the CNS, first appearing at stage 11 and persisting at least through stage 14. Transcript is detected in the dMP2 neurons throughout this time, however, expression in the vMP2 neuron only persists through stage 12 in many cases. Transcript is also detected in VUMs and two more cells in each hemisegment. (Swiss-Prot Project Members, 1998.12.15)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage 11 -- 12   vMP2 neuron   (Swiss-Prot Project Members, 1998.12.15) embryonic stage 11 -- 14   dMP2 neuron   (Swiss-Prot Project Members, 1998.12.15) embryonic stage 12 -- 13   embryonic myoblast | subset   (Yarnitzky et al., 1998)
Additional Descriptive Data
	vn protein expression in embryonic somatic muscle precursor cells colocalizes with Kr protein expression. (Yarnitzky et al., 1998)
Marker for
	embryonic myoblast
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0003984    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0003984 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of very low expression. Peak expression observed at stages throughout embryogenesis, during late pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0003984 expression level Developmental Stage   Expression Level embryo 00-02hr    34 embryo 02-04hr    254 embryo 04-06hr    823 embryo 06-08hr    748 embryo 08-10hr    606 embryo 10-12hr    267 embryo 12-14hr    435 embryo 14-16hr    498 embryo 16-18hr    650 embryo 18-20hr    427 embryo 20-22hr    170 embryo 22-24hr    188 larva L1    168 larva L2    146 larva L3 12hr old    151 larva L3 puffstage 1-2    95 larva L3 puffstage 3-6    203 larva L3 puffstage 7-9    225 white prepupae new    222 white prepupae 12hr    284 white prepupae 24hr    347 pupae 2d postWPP    353 pupae 3d postWPP    532 pupae 4d postWPP    277 adult male 01day    219 adult male 05day    249 adult male 30day    207 adult female 01day    122 adult female 05day    45 adult female 30day    60 Expression Level Scale  None   Extremely low   Very low   Low   Moderate  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    34 embryo 02-04hr  (254) embryo 04-06hr  (823) embryo 06-08hr  (748) embryo 08-10hr  (606) embryo 10-12hr  (267) embryo 12-14hr  (435) embryo 14-16hr  (498) embryo 16-18hr  (650) embryo 18-20hr  (427) embryo 20-22hr  (170) embryo 22-24hr  (188) larva L1  (168) larva L2  (146) larva L3 12hr old  (151) larva L3 puffstage 1-2    95 larva L3 puffstage 3-6  (203) larva L3 puffstage 7-9  (225) white prepupae new  (222) white prepupae 12hr  (284) white prepupae 24hr  (347) pupae 2d postWPP  (353) pupae 3d postWPP  (532) pupae 4d postWPP  (277) adult male 01day  (219) adult male 05day  (249) adult male 30day  (207) adult female 01day  (122) adult female 05day    45 adult female 30day    60 Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    34 embryo 02-04hr    254 embryo 04-06hr    823 embryo 06-08hr    748 embryo 08-10hr    606 embryo 10-12hr    267 embryo 12-14hr    435 embryo 14-16hr    498 embryo 16-18hr    650 embryo 18-20hr    427 embryo 20-22hr    170 embryo 22-24hr    188 larva L1    168 larva L2    146 larva L3 12hr old    151 larva L3 puffstage 1-2    95 larva L3 puffstage 3-6    203 larva L3 puffstage 7-9    225 white prepupae new    222 white prepupae 12hr    284 white prepupae 24hr    347 pupae 2d postWPP    353 pupae 3d postWPP    532 pupae 4d postWPP    277 adult male 01day    219 adult male 05day    249 adult male 30day    207 adult female 01day    122 adult female 05day    45 adult female 30day    60 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    34 embryo 02-04hr    254 embryo 04-06hr    823 embryo 06-08hr    748 embryo 08-10hr    606 embryo 10-12hr    267 embryo 12-14hr    435 embryo 14-16hr    498 embryo 16-18hr    650 embryo 18-20hr    427 embryo 20-22hr    170 embryo 22-24hr    188 larva L1    168 larva L2    146 larva L3 12hr old    151 larva L3 puffstage 1-2    95 larva L3 puffstage 3-6    203 larva L3 puffstage 7-9    225 white prepupae new    222 white prepupae 12hr    284 white prepupae 24hr    347 pupae 2d postWPP    353 pupae 3d postWPP    532 pupae 4d postWPP    277 adult male 01day    219 adult male 05day    249 adult male 30day    207 adult female 01day    122 adult female 05day    45 adult female 30day    60 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    34 embryo 02-04hr    254 embryo 04-06hr    823 embryo 06-08hr    748 embryo 08-10hr    606 embryo 10-12hr    267 embryo 12-14hr    435 embryo 14-16hr    498 embryo 16-18hr    650 embryo 18-20hr    427 embryo 20-22hr    170 embryo 22-24hr    188 larva L1    168 larva L2    146 larva L3 12hr old    151 larva L3 puffstage 1-2    95 larva L3 puffstage 3-6    203 larva L3 puffstage 7-9    225 white prepupae new    222 white prepupae 12hr    284 white prepupae 24hr    347 pupae 2d postWPP    353 pupae 3d postWPP    532 pupae 4d postWPP    277 adult male 01day    219 adult male 05day    249 adult male 30day    207 adult female 01day    122 adult female 05day    45 adult female 30day    60 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0003984 expression level Developmental Stage   Expression Level embryo 00-02hr    34 embryo 02-04hr    254 embryo 04-06hr    823 embryo 06-08hr    748 embryo 08-10hr    606 embryo 10-12hr    267 embryo 12-14hr    435 embryo 14-16hr    498 embryo 16-18hr    650 embryo 18-20hr    427 embryo 20-22hr    170 embryo 22-24hr    188 larva L1    168 larva L2    146 larva L3 12hr old    151 larva L3 puffstage 1-2    95 larva L3 puffstage 3-6    203 larva L3 puffstage 7-9    225 white prepupae new    222 white prepupae 12hr    284 white prepupae 24hr    347 pupae 2d postWPP    353 pupae 3d postWPP    532 pupae 4d postWPP    277 adult male 01day    219 adult male 05day    249 adult male 30day    207 adult female 01day    122 adult female 05day    45 adult female 30day    60 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    34 embryo 02-04hr  (254) embryo 04-06hr  (823) embryo 06-08hr  (748) embryo 08-10hr  (606) embryo 10-12hr  (267) embryo 12-14hr  (435) embryo 14-16hr  (498) embryo 16-18hr  (650) embryo 18-20hr  (427) embryo 20-22hr  (170) embryo 22-24hr  (188) larva L1  (168) larva L2  (146) larva L3 12hr old  (151) larva L3 puffstage 1-2    95 larva L3 puffstage 3-6  (203) larva L3 puffstage 7-9  (225) white prepupae new  (222) white prepupae 12hr  (284) white prepupae 24hr  (347) pupae 2d postWPP  (353) pupae 3d postWPP  (532) pupae 4d postWPP  (277) adult male 01day  (219) adult male 05day  (249) adult male 30day  (207) adult female 01day  122 adult female 05day    45 adult female 30day    60 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    34 embryo 02-04hr    254 embryo 04-06hr    823 embryo 06-08hr    748 embryo 08-10hr    606 embryo 10-12hr    267 embryo 12-14hr    435 embryo 14-16hr    498 embryo 16-18hr    650 embryo 18-20hr    427 embryo 20-22hr    170 embryo 22-24hr    188 larva L1    168 larva L2    146 larva L3 12hr old    151 larva L3 puffstage 1-2    95 larva L3 puffstage 3-6    203 larva L3 puffstage 7-9    225 white prepupae new    222 white prepupae 12hr    284 white prepupae 24hr    347 pupae 2d postWPP    353 pupae 3d postWPP    532 pupae 4d postWPP    277 adult male 01day    219 adult male 05day    249 adult male 30day    207 adult female 01day    122 adult female 05day    45 adult female 30day    60 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    34 embryo 02-04hr    254 embryo 04-06hr    823 embryo 06-08hr    748 embryo 08-10hr    606 embryo 10-12hr    267 embryo 12-14hr    435 embryo 14-16hr    498 embryo 16-18hr    650 embryo 18-20hr    427 embryo 20-22hr    170 embryo 22-24hr    188 larva L1    168 larva L2    146 larva L3 12hr old    151 larva L3 puffstage 1-2    95 larva L3 puffstage 3-6    203 larva L3 puffstage 7-9    225 white prepupae new    222 white prepupae 12hr    284 white prepupae 24hr    347 pupae 2d postWPP    353 pupae 3d postWPP    532 pupae 4d postWPP    277 adult male 01day    219 adult male 05day    249 adult male 30day    207 adult female 01day    122 adult female 05day    45 adult female 30day    60 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    34 embryo 02-04hr    254 embryo 04-06hr    823 embryo 06-08hr    748 embryo 08-10hr    606 embryo 10-12hr    267 embryo 12-14hr    435 embryo 14-16hr    498 embryo 16-18hr    650 embryo 18-20hr    427 embryo 20-22hr    170 embryo 22-24hr    188 larva L1    168 larva L2    146 larva L3 12hr old    151 larva L3 puffstage 1-2    95 larva L3 puffstage 3-6    203 larva L3 puffstage 7-9    225 white prepupae new    222 white prepupae 12hr    284 white prepupae 24hr    347 pupae 2d postWPP    353 pupae 3d postWPP    532 pupae 4d postWPP    277 adult male 01day    219 adult male 05day    249 adult male 30day    207 adult female 01day    122 adult female 05day    45 adult female 30day    60 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0003984    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0003984 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0003984 expression level Tissue   Expression Level Larval Central Nervous System    26.025 Larval Midgut    13.7 Larval Hindgut    24.2 Larval Malpighian Tubules    42 Larval Fat Body    2.5 Larval Salivary Gland    3.1 Larval Trachea    47.7 Larval Carcass    32.375 Adult Head    21.1 Adult Eye    79.1 Adult Brain    8.2 Adult Thoracic-Abdominal Ganglion    10.5 Adult Crop    42.2 Adult Midgut    7.5 Adult Hindgut    18 Adult Malpighian Tubules    36.5 Adult Fat Body    11.6 Adult Salivary Gland    4.5 Adult Heart    50.475 Adult VirginFemale Spermatheca    8.5 Adult InseminatedFemale Spermatheca    9.4 Adult Ovary    8.3 Adult Testis    5.1 Adult Male Accessory Gland    8.8 Adult Carcass no informative data Expression Level Scale  None   Low  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    26.025 Larval Midgut    13.7 Larval Hindgut    24.2 Larval Malpighian Tubules    42 Larval Fat Body    2.5 Larval Salivary Gland    3.1 Larval Trachea    47.7 Larval Carcass    32.375 Adult Head    21.1 Adult Eye    79.1 Adult Brain    8.2 Adult Thoracic-Abdominal Ganglion    10.5 Adult Crop    42.2 Adult Midgut    7.5 Adult Hindgut    18 Adult Malpighian Tubules    36.5 Adult Fat Body    11.6 Adult Salivary Gland    4.5 Adult Heart    50.475 Adult VirginFemale Spermatheca    8.5 Adult InseminatedFemale Spermatheca    9.4 Adult Ovary    8.3 Adult Testis    5.1 Adult Male Accessory Gland    8.8 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    26.025 Larval Midgut    13.7 Larval Hindgut    24.2 Larval Malpighian Tubules    42 Larval Fat Body    2.5 Larval Salivary Gland    3.1 Larval Trachea    47.7 Larval Carcass    32.375 Adult Head    21.1 Adult Eye    79.1 Adult Brain    8.2 Adult Thoracic-Abdominal Ganglion    10.5 Adult Crop    42.2 Adult Midgut    7.5 Adult Hindgut    18 Adult Malpighian Tubules    36.5 Adult Fat Body    11.6 Adult Salivary Gland    4.5 Adult Heart    50.475 Adult VirginFemale Spermatheca    8.5 Adult InseminatedFemale Spermatheca    9.4 Adult Ovary    8.3 Adult Testis    5.1 Adult Male Accessory Gland    8.8 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    26.025 Larval Midgut    13.7 Larval Hindgut    24.2 Larval Malpighian Tubules    42 Larval Fat Body    2.5 Larval Salivary Gland    3.1 Larval Trachea    47.7 Larval Carcass    32.375 Adult Head    21.1 Adult Eye    79.1 Adult Brain    8.2 Adult Thoracic-Abdominal Ganglion    10.5 Adult Crop    42.2 Adult Midgut    7.5 Adult Hindgut    18 Adult Malpighian Tubules    36.5 Adult Fat Body    11.6 Adult Salivary Gland    4.5 Adult Heart    50.475 Adult VirginFemale Spermatheca    8.5 Adult InseminatedFemale Spermatheca    9.4 Adult Ovary    8.3 Adult Testis    5.1 Adult Male Accessory Gland    8.8 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0003984 expression level Tissue   Expression Level Larval Central Nervous System    26.025 Larval Midgut    13.7 Larval Hindgut    24.2 Larval Malpighian Tubules    42 Larval Fat Body    2.5 Larval Salivary Gland    3.1 Larval Trachea    47.7 Larval Carcass    32.375 Adult Head    21.1 Adult Eye    79.1 Adult Brain    8.2 Adult Thoracic-Abdominal Ganglion    10.5 Adult Crop    42.2 Adult Midgut    7.5 Adult Hindgut    18 Adult Malpighian Tubules    36.5 Adult Fat Body    11.6 Adult Salivary Gland    4.5 Adult Heart    50.475 Adult VirginFemale Spermatheca    8.5 Adult InseminatedFemale Spermatheca    9.4 Adult Ovary    8.3 Adult Testis    5.1 Adult Male Accessory Gland    8.8 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    26.025 Larval Midgut    13.7 Larval Hindgut    24.2 Larval Malpighian Tubules    42 Larval Fat Body    2.5 Larval Salivary Gland    3.1 Larval Trachea    47.7 Larval Carcass    32.375 Adult Head    21.1 Adult Eye    79.1 Adult Brain    8.2 Adult Thoracic-Abdominal Ganglion    10.5 Adult Crop    42.2 Adult Midgut    7.5 Adult Hindgut    18 Adult Malpighian Tubules    36.5 Adult Fat Body    11.6 Adult Salivary Gland    4.5 Adult Heart    50.475 Adult VirginFemale Spermatheca    8.5 Adult InseminatedFemale Spermatheca    9.4 Adult Ovary    8.3 Adult Testis    5.1 Adult Male Accessory Gland    8.8 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    26.025 Larval Midgut    13.7 Larval Hindgut    24.2 Larval Malpighian Tubules    42 Larval Fat Body    2.5 Larval Salivary Gland    3.1 Larval Trachea    47.7 Larval Carcass    32.375 Adult Head    21.1 Adult Eye    79.1 Adult Brain    8.2 Adult Thoracic-Abdominal Ganglion    10.5 Adult Crop    42.2 Adult Midgut    7.5 Adult Hindgut    18 Adult Malpighian Tubules    36.5 Adult Fat Body    11.6 Adult Salivary Gland    4.5 Adult Heart    50.475 Adult VirginFemale Spermatheca    8.5 Adult InseminatedFemale Spermatheca    9.4 Adult Ovary    8.3 Adult Testis    5.1 Adult Male Accessory Gland    8.8 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    26.025 Larval Midgut    13.7 Larval Hindgut    24.2 Larval Malpighian Tubules    42 Larval Fat Body    2.5 Larval Salivary Gland    3.1 Larval Trachea    47.7 Larval Carcass    32.375 Adult Head    21.1 Adult Eye    79.1 Adult Brain    8.2 Adult Thoracic-Abdominal Ganglion    10.5 Adult Crop    42.2 Adult Midgut    7.5 Adult Hindgut    18 Adult Malpighian Tubules    36.5 Adult Fat Body    11.6 Adult Salivary Gland    4.5 Adult Heart    50.475 Adult VirginFemale Spermatheca    8.5 Adult InseminatedFemale Spermatheca    9.4 Adult Ovary    8.3 Adult Testis    5.1 Adult Male Accessory Gland    8.8 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    21.1   NA  Eye    79.1   NA  Brain    8.2   26.025  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    10.5   NA  Crop    42.2   13.7  Midgut    7.5   24.2  Hindgut    18   42  Malpighian Tubules    36.5   2.5  Fat Body    11.6   3.1  Salivary Gland    4.5   NA  Heart    50.475   47.7  Trachea    NA   NA  VirginFemale Spermatheca    8.5   NA  InseminatedFemale Spermatheca    9.4   NA  Ovary    8.3   NA  Testis    5.1   NA  Male Accessory Gland    8.8   32.375  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_11
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003984 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10491-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL469B vnΔPEST.Scer\UAS lethal, with Scer\GAL471B vnΔIg.Scer\UAS vnΔPEST.Scer\UAS lethal | embryonic stage vnM1 vnM2 vnM3 vnM4 lethal | embryonic stage, with Scer\GAL469B vnΔIg.Scer\UAS vnΔMR93-213.Scer\UAS lethal | embryonic stage | recessive vnddd-4 vnγ4 lethal | heat sensitive vnddd-13 lethal | larval stage | partially vnddd-3 lethal | partially | pupal stage, with Scer\GAL469B vnScer\UAS.cSa lethal | pharate adult stage (with vn10567) vnγ7 lethal | pharate adult stage (with vnγ7) vn10567 lethal | prepupal stage | recessive vnD4 vnddd-3 vnL6 lethal | pupal stage, with Scer\GAL471B vnΔMR93-213.Scer\UAS lethal | pupal stage | recessive vnγ5 vnγ7 lethal | recessive vn65 vn79 vn643 vn10567 vnL6 vnM1 vnM2 vnrF264 vnγ4 vnγ6 semi-viable, with Scer\GAL471B vnScer\UAS.cSa viable vn1 vnwvn Sterility Allele male sterile vnγ6 Other Phenotypes Allele decreased cell number | larval stage (with vn10567) vnγ7 decreased cell number | larval stage (with vnγ7) vn10567 decreased cell number | late third instar larval stage, with Scer\GAL4how-24B, Scer\GAL80ts.αTub84B vnGD2321 decreased cell number | late third instar larval stage | recessive vn10567 vnγ7 neuroanatomy defective | embryonic stage vnL6 visible vn1 vnwvn visible, with Scer\GAL4[-]: vnScer\UAS.cSa visible, with Scer\GAL469B vnScer\UAS.cSa vnΔEGF.Scer\UAS vnΔMR177-395.Scer\UAS vnΔMR395-476.Scer\UAS visible, with Scer\GAL471B vnScer\UAS.cSa visible, with Scer\GAL4bs-1348 vnEGF.Scer\UAS vnScer\UAS.cSa vnΔIg.Scer\UAS vnΔMR93-213.Scer\UAS vnΔPEST.Scer\UAS visible, with Scer\GAL4GMR.PF vnEGF.Scer\UAS visible, with Scer\GAL4kni.L2 vnScer\UAS.cSa visible, with Scer\GAL4ptc-559.1 vnScer\UAS.cSa visible (with vn1) vnC221 visible (with vnC221) vn1 visible | homeotic, with Scer\GAL4bi-md653 vnScer\UAS.cSa visible | recessive vn1 vnddd-3 vnM2 Phenotype manifest in Allele abdominal 2 dorsal acute muscle 1 | precursor vn10567 vnL6 abdominal 2 lateral longitudinal muscle 1 | precursor vnL6 abdominal 2 ventral acute muscle 2 | precursor vnL6 abdominal 3 dorsal acute muscle 1 | precursor vn10567 vnL6 abdominal 3 lateral longitudinal muscle 1 | precursor vnL6 abdominal 3 ventral acute muscle 2 | precursor vnL6 abdominal 4 dorsal acute muscle 1 | precursor vn10567 vnL6 abdominal 4 lateral longitudinal muscle 1 | precursor vnL6 abdominal 4 ventral acute muscle 2 | precursor vnL6 abdominal 5 dorsal acute muscle 1 | precursor vn10567 vnL6 abdominal 5 lateral longitudinal muscle 1 | precursor vnL6 abdominal 5 ventral acute muscle 2 | precursor vnL6 abdominal 6 dorsal acute muscle 1 | precursor vn10567 vnL6 abdominal 6 lateral longitudinal muscle 1 | precursor vnL6 abdominal 6 ventral acute muscle 2 | precursor vnL6 abdominal 7 dorsal acute muscle 1 | precursor vn10567 vnL6 abdominal 7 lateral longitudinal muscle 1 | precursor vnL6 abdominal 7 ventral acute muscle 2 | precursor vnL6 adult cuticle & head capsule | dorsal vnddd-3 adult midgut precursor cell | larval stage (with vn10567) vnγ7 adult midgut precursor cell | larval stage (with vnγ7) vn10567 adult midgut precursor cell | late third instar larval stage vnγ7 vn10567 adult midgut precursor cell | late third instar larval stage, with Scer\GAL4how-24B, Scer\GAL80ts.αTub84B vnGD2321 anterior crossvein vn1 vnC221 vnddd-13 vnwvn anterior fascicle sensory neuron vnL6 border follicle cell, with Scer\GAL4nos.UTR.T:Hsim\VP16 vnEPg35521 border follicle cell, with Scer\GAL4nos.UTR.T:Hsim\VP16, Scer\GAL4slbo.2.6 vnEPg35521 border follicle cell, with Scer\GAL4slbo.2.6 vnEPg35521 vnScer\UAS.cSa border follicle cell & filopodium, with Scer\GAL4slbo.2.6 vnEPg35521 border follicle cell | somatic clone, with Scer\GAL4cb41 vnΔMR93-213.Scer\UAS capitellum, with Scer\GAL4bi-md653 vnScer\UAS.cSa chordotonal organ | embryonic stage vnL6 crossvein vn1 dMP2 neuron (with Df(3L)γ3) vnγ4 dorsal mesothoracic disc & peripodial epithelium | somatic clone, with Scer\GAL4αTub84B.PL vnScer\UAS.cSa dorsal mesothoracic disc & peripodial epithelium | somatic clone | cell non-autonomous, with Scer\GAL4αTub84B.PL vnScer\UAS.cSa dorsal oblique muscle vn10567 embryonic/first instar larval cuticle | ventral vnddd-4 embryonic/larval brain vnddd-3 embryonic/larval brain, with Scer\GAL4T80 vnΔIg.Scer\UAS embryonic/larval midgut | embryonic stage vnγ4 vn10567 embryonic/larval somatic muscle vn10567 embryonic/larval somatic muscle, with Scer\GAL469B vnScer\UAS.cYa embryonic/larval somatic muscle, with Scer\GAL4Kr.PM vnScer\UAS.cYa embryonic/larval somatic muscle, with Scer\GAL4twi.PG vnScer\UAS.cYa embryonic central brain vnΔP25 eye, with Scer\GAL4GMR.PF vnEGF.Scer\UAS gastric caecum vnγ4 vn10567 haltere disc vnddd-3 imaginal disc vnL6 imaginal disc, with Scer\GAL4T80 vnΔIg.Scer\UAS interface glial cell, with Scer\GAL415J2 vndsRNA.Scer\UAS interface glial cell, with Scer\GAL4elav.PLu vndsRNA.Scer\UAS interface glial cell (with Df(3L)γ3) vnγ4 intermediate longitudinal fascicle (with Df(3L)γ3) vnγ4 Keilin's organ vnγ4 vnddd-4 Kolbchen vnddd-4 larva vnL6 lateral longitudinal fascicle (with Df(3L)γ3) vnγ4 lch5 ligament attachment cell (with Df(3L)v65c) vn10567 lch5 ligament attachment cell | supernumerary, with Scer\GAL4repo vnScer\UAS.cYa longitudinal connective vnunspecified longitudinal connective (with Df(3L)γ3) vnγ4 midgut, with Scer\GAL4how-24B, Scer\GAL80ts.αTub84B vnVDRC.cUa vnScer\UAS.cSa midgut constriction 1 vnγ4 vn10567 midgut constriction 2 vnγ4 vn10567 midgut constriction 3 vnγ4 vn10567 midline glial cell vnunspecified muscle attachment site vnL6 ocellar bristle vnddd-3 ocellus vnddd-3 posterior crossvein vn1 posterior fascicle sensory neuron vnL6 postvertical bristle vnddd-3 scutum vnγ6 sensory neuron & axon & embryo vnL6 ventral longitudinal muscle vn10567 ventral nerve cord | larval stage vnddd-3 ventral nerve cord commissure vnunspecified ventral oblique muscle vn10567 wing vnγ4 vnγ5 vnγ7 vn1 vnC221 vnD4 vnL6 vnddd-13 vnddd-3 wing, with Scer\GAL471B vnΔMR93-213.Scer\UAS vnScer\UAS.cSa wing, with Scer\GAL4bs-1348 vnΔMR93-213.Scer\UAS wing, with Scer\GAL4kni.L2 vnScer\UAS.cSa wing disc vnL6 vnddd-3 wing disc (with vnddd-4) vnL6 wing disc (with vnL6) vnddd-4 wing margin, with Scer\GAL469B vnΔIg.Scer\UAS wing margin bristle | ectopic, with Scer\GAL4bi-md653 vnScer\UAS.cSa wing vein vn1 vnM1 wing vein, with Scer\GAL469B vnScer\UAS.cSa wing vein, with Scer\GAL4bs-1348 vnEGF.Scer\UAS vnScer\UAS.cSa wing vein | ectopic, with Scer\GAL4[-]: vnScer\UAS.cSa wing vein | ectopic, with Scer\GAL469B vnΔIg.Scer\UAS vnΔMR177-395.Scer\UAS vnΔMR395-476.Scer\UAS vnScer\UAS.cSa wing vein | ectopic, with Scer\GAL471B vnScer\UAS.cSa wing vein | ectopic, with Scer\GAL4bs-1348 vnΔIg.Scer\UAS vnΔMR93-213.Scer\UAS vnΔPEST.Scer\UAS vnScer\UAS.cSa wing vein | ectopic, with Scer\GAL4kni.L2 vnScer\UAS.cSa wing vein | ectopic, with Scer\GAL4ptc-559.1 vnScer\UAS.cSa wing vein L3 vn1 wing vein L4 vn1 vnC221 vnddd-3 vnwvn wing vein L4, with Scer\GAL469B vnΔEGF.Scer\UAS wing vein L4 (with vn1) vnC221 wing vein L4 (with vnC221) vn1
Classical Alleles ( 44 )
For All Classical Alleles Show
Allele of vn Class Mutagen Stocks Known lesion vn1 loss of function allele X ray 5 Yes vnC221 ethyl methanesulfonate 2 -- vn10567 loss of function allele P-element activity 1 Yes vnc01194 1 -- vne01186 piggyBac transposase 1 -- vne03173 piggyBac transposase 1 -- vnMI01897 1 -- vnNP6643 1 -- vnddd-4 amorphic allele - genetic evidence ethyl methanesulfonate 0 Yes vnγ4 loss of function allele, amorphic allele - genetic evidence gamma ray 0 Yes vn147-2 0 -- vn643 ethyl methanesulfonate 0 -- vn65 PM hybrid dysgenesis 0 Yes vn79 PM hybrid dysgenesis 0 Yes vnaddC6 0 -- vnD4 PM hybrid dysgenesis 0 Yes vnddd-10 ethyl methanesulfonate 0 Yes vnddd-11 ethyl methanesulfonate 0 Yes vnddd-12 ethyl methanesulfonate 0 Yes vnddd-13 ethyl methanesulfonate 0 Yes vnddd-1 ethyl methanesulfonate 0 -- vnddd-2 ethyl methanesulfonate 0 Yes vnddd-3 ethyl methanesulfonate 0 Yes vnddd-5 ethyl methanesulfonate 0 -- vnddd-6 ethyl methanesulfonate 0 -- vnddd-7 ethyl methanesulfonate 0 Yes vnddd-8 ethyl methanesulfonate 0 -- vnddd-9 ethyl methanesulfonate 0 -- vnEPg35521 P-element activity 0 Yes vnfw 0 -- vnL6 ethyl methanesulfonate 0 Yes vnM1 0 -- vnM2 0 -- vnM3 0 -- vnM4 0 -- vnrF264 P-element activity 0 -- vnry 0 -- vnunspecified 0 -- vnWA178 ethyl methanesulfonate 0 Yes vnwvn PM hybrid dysgenesis 0 Yes vnγ5 gamma ray 0 Yes vnγ6 hypomorphic allele - genetic evidence gamma ray 0 Yes vnγ7 gamma ray 0 Yes vnΔP25 loss of function allele P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 17 )
For All Alleles Carried on Transgenic Constructs Show
Allele of vn Class Mutagen Stocks Known lesion vnGD2321 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes vnas.Scer\UAS in vitro construct - regulatory fusion 0 Yes vndsRNA.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes vnEGF.MtnA in vitro construct - regulatory fusion 0 Yes vnEGF.Scer\UAS in vitro construct - coding region fusion 0 Yes vnKK108432 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes vnMtnA.PS in vitro construct - regulatory fusion 0 Yes vnScer\UAS.cSa in vitro construct - regulatory fusion 0 Yes vnScer\UAS.cYa in vitro construct - regulatory fusion 0 Yes vnScer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes vnVDRC.cUa in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes vnΔEGF.Scer\UAS in vitro construct - regulatory fusion 0 Yes vnΔIg.Scer\UAS in vitro construct - regulatory fusion 0 Yes vnΔMR177-395.Scer\UAS in vitro construct - regulatory fusion 0 Yes vnΔMR395-476.Scer\UAS in vitro construct - regulatory fusion 0 Yes vnΔMR93-213.Scer\UAS in vitro construct - regulatory fusion 0 Yes vnΔPEST.Scer\UAS in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)64D-F (Garcia-Bellido et al., 1994) Df(3L)BSC410 (Christensen et al., 2008.4.15) Df(3L)BSC437 (Christensen et al., 2008.4.15) Df(3L)BSC438 (Christensen et al., 2008.4.15) Df(3L)Exel6107 (Ryder, 2004.4.26) Df(3L)XAS96 (Yarnitzky et al., 1997) Df(3L)ZN47 (Spradling et al., 1999, BDGP Project Members, 1994-1999, Price et al., 1997) Df(3L)γ1 (Simcox et al., 1996) Df(3L)γ2 (Simcox et al., 1996) Df(3L)γ3 (Simcox et al., 1996, Schnepp et al., 1996) T(1;3)vnγ6 (Simcox et al., 1996) T(2;3)vnγ4 (Simcox et al., 1996)
Duplicated in	Dp(3;3)pdp7 (Garcia-Bellido et al., 1994)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD2321} NA P{GD8934} NA P{GD15171} NA P{GD15730} NA P{KK108432} NA P{UAS-vn.as} NA P{UAS-vn.dsRNA} NA P{UAS-vn.EGF} NA P{UAS-vn.GFP} NA P{UAS-vn.S} NA P{UAS-vn.Y} NA P{UAS-vn.ΔEGF} NA P{UAS-vn.ΔIg} NA P{UAS-vn.ΔMR93-213} NA P{UAS-vn.ΔMR177-395} NA P{UAS-vn.ΔMR395-476} NA P{UAS-vn.ΔPEST} NA reporter construct P{Dm.vnNEE-lacZ.919} No P{vn.497-lacZ} No P{vn.NEE-lacZ} No P{vn-lacZ.H-Pelican} No P{vn-lacZ.S} No characterization construct P{UAS-vn.A3S4A} NA P{UAS-vn.A3S} NA P{UAS-vn.A4S} NA P{UAS-vn.S3A4S} NA P{UAS-vn.S3A} NA P{UAS-vn.S4A} NA P{UAS-vn-gil.EGF} NA P{UAS-vn-spi.EGF} NA P{VDRC.vn.U} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{PZ}vn10567 No P{PZ}vnrF264 No miscellaneous insertions Mi{MIC}vnMI01897 NA P{}vn65 NA P{}vn79 NA P{}vnD4 NA P{}vnwvn NA PBac{PB}vnc01194 NA PBac{RB}vne01186 NA PBac{RB}vne03173 NA insertion of enhancer trap binary system P{GawB}vnNP6643 No insertion of mobile activating element P{EPg}vnEPg35521 NA
Gene Ontology: Function, Process & Cellular Component ( 21 unique terms )
Terms Based on Experimental Evidence ( 13 terms )
Molecular Function
CV term Evidence References
epidermal growth factor receptor binding inferred from mutant phenotype (assigned by UniProtKB) (Schnepp et al., 1996)
Biological Process
CV term Evidence References
border follicle cell migration inferred from mutant phenotype (McDonald et al., 2006) brain development inferred from mutant phenotype (Page, 2003) cell projection assembly inferred from mutant phenotype (Fulga and Rorth, 2002) epidermal growth factor receptor signaling pathway inferred from mutant phenotype (assigned by UniProtKB) (Schnepp et al., 1996) haltere development inferred from mutant phenotype (Pallavi et al., 2006) imaginal disc-derived wing morphogenesis inferred from mutant phenotype (Wang et al., 2000) imaginal disc-derived wing vein morphogenesis inferred from mutant phenotype (Ralston and Blair, 2005) midgut development inferred from mutant phenotype (Jiang and Edgar, 2009) notum cell fate specification inferred from mutant phenotype (Wang et al., 2000) notum development inferred from mutant phenotype (Wang et al., 2000) peripheral nervous system development inferred from mutant phenotype (Sepp and Auld, 2003) positive regulation of cell proliferation inferred from mutant phenotype (Buchon et al., 2010, Jiang and Edgar, 2009)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 10 terms )
Molecular Function
CV term Evidence References
epidermal growth factor receptor binding non-traceable author statement (van Eeden and St. Johnston, 1999, Swiss-Prot Project Members, 2000.10.1) traceable author statement (Brower, 2003, Bier, 1998, Shilo, 2003)
Biological Process
CV term Evidence References
anti-apoptosis traceable author statement (Hidalgo, 2002) cell-cell signaling traceable author statement (Lamka and Lipshitz, 1999) epidermal growth factor receptor signaling pathway non-traceable author statement (Bogdan and Klaembt, 2001) traceable author statement (Bier, 1998, Shilo, 2003) imaginal disc-derived wing vein specification traceable author statement (Milan and Cohen, 2000) leg disc proximal/distal pattern formation traceable author statement (Mann and Casares, 2002) muscle attachment traceable author statement (Shilo, 2003) positive regulation of epidermal growth factor receptor signaling pathway non-traceable author statement (van Eeden and St. Johnston, 1999)
Cellular Component
CV term Evidence References
extracellular region non-traceable author statement (Swiss-Prot Project Members, 2000.10.1) non-traceable author statement (assigned by UniProtKB) (Schnepp et al., 1996) traceable author statement (Brower, 2003, Bier, 1998) plasma membrane non-traceable author statement (Bogdan and Klaembt, 2001)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions vn allele Gene References vn1 bs (Roch et al., 1998) emc (Baonza and Garcia-Bellido, 1999) H (Johannes and Preiss, 2002) rho (Roch et al., 1998, Ralston and Blair, 2005) tum (Sotillos and Campuzano, 2000) vn10567 Egfr (Yarnitzky et al., 1998) Ras85D (Wasserman and Freeman, 1998) spi (Yarnitzky et al., 1998) vnC221 E(Egfr)B56 (Price et al., 1997) E(Egfr)C12 (Price et al., 1997) Egfr (Price et al., 1997) gro (Price et al., 1997) H (Price et al., 1997) N (Price et al., 1997) Su(H) (Price et al., 1997) vnddd-3 bs (Roch et al., 1998) emc (Baonza and Garcia-Bellido, 1999) vnddd-4 ap (Zecca and Struhl, 2002) rho (Zecca and Struhl, 2002) spi (Schnepp et al., 1996) vnddd-13 Egfr (Schnepp et al., 1996) rl (Schnepp et al., 1996) vnEPg35521 Pvr (Duchek et al., 2001) vnL6 ap (Zecca and Struhl, 2002) Egfr (Schnepp et al., 1996, Yarnitzky et al., 1998) ptc (Wessells et al., 1999) rho (Zecca and Struhl, 2002) rl (Schnepp et al., 1996) spi (Schnepp et al., 1996) vnM2 bs (Roch et al., 1998) rho (Roch et al., 1998) vnScer\UAS.cSa aos (Wessells et al., 1999) Pros26 (Donaldson et al., 2004) Prosβ2 (Donaldson et al., 2004) ptc (Wessells et al., 1999) vnScer\UAS.cYa mys (Martin-Bermudo, 2000) vnunspecified Egfr (Diaz-Benjumea and Garcia-Bellido, 1990, Spencer et al., 1998) rho (Diaz-Benjumea and Garcia-Bellido, 1990) spi (Lanoue et al., 2000) vnΔIg.Scer\UAS aos (Donaldson et al., 2004) unspecified ash1 (McEwen et al., 2000) brm (Armstrong et al., 2005) bs (Montagne et al., 1996) Egfr (Pallavi et al., 2006) Pvf1 (Duchek et al., 2001) rho (Sturtevant and Bier, 1995) Ubx (Pallavi et al., 2006)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 64117 DroID - A comprehensive database of gene and protein interactions. • FBgn0003984 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38657
Orthologs
Genome-wide drosophilid orthologs	Dana\vn Dere\GG14106 Dgri\GH17034 Dmoj\GI12038 Dper\GL21406 Dpse\GA10349 Dsec\GM13892 Dsim\GD13173 Dvir\GJ13308 Dwil\vn Dyak\GE20531
Curated drosophilid orthologs	Dpse\GA10349   Dpse\vn (Donaldson et al., 2004) Dvir\vn (Donaldson et al., 2004)
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL012517-PA Aedes aegypti (mosquito) AGAP007110-PA Anopheles gambiae (mosquito) ENSECAP00000018365 Equus caballus (horse) ENSGALP00000039426 Gallus gallus (chicken) ENSP00000239926 Homo sapiens (human) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB13961 NV17888 LH13695 ISCW006065 FBgn0237844 FBgn0218660 FBgn0200534 FBgn0184895 FBgn0168823 JGI_V11_98516 FBgn0070407 FBgn0158999 FBgn0134795 FBgn0124505 FBgn0106368 FBgn0098516 FBgn0087481 CPIJ004964 CPIJ004965 CPIJ004966 BGIBMGA012742 ACYPI34621 ACYPI34620 GB18384 AGAP007110 AAEL012979 AAEL012977 AAEL012517 PHUM059700 PHUM060010 GLEAN_14604
Stocks & Reagents
Stocks Listed in FlyBase ( 14 )
Bloomington	2460 vnC221/TM3, Sb1 35953 y1 w*; Mi{MIC}vnMI01897 7287 l(3)93589358 vn1 st1/DcxF 7288 l(3)B197B197 vn1 st1/DcxF 7291 mtacp11303 vn1 st1/TM6B, Tb1 7284 l(3)8E2768E276 vn1 st1/TM6B, Tb1 7292 l(3)026407E130 vn1 st1/TM6B, Tb1
Harvard	- PBac{PB}vnc01194 - PBac{RB}vne01186 - PBac{RB}vne03173
Kyoto	107344 vnC221/TM3, Sb1
VDRC	v50358 w1118; P{GD2321}v50358/TM3
	More stocks available...
Genomic Clones ( 2 )
	BACR11A21 BACR29P05 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 60 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	IP15007
Other clones	MIP03566 RT01891 RT02058 RT02059
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LP21849
Other clones	8353 56496 104316 125328 CK01.45D.C1 CK01.74C.G8 CK01.79A.E5 CK01.82B.H9 CK01.86A.D9 CK01.104C.B6 CK01.117B.D12 CK01.145C.D8 EK064831 EK067915 EK072209 EK087639 EK106940 EK119648 EK200445 EK229354 EK247461 IP03207 IP03307 IP03407 IP03507 IP14807 IP14907 RP004037666 RP004038768 RP004057041 RP004083373 RP004118840 RP004168688 RP004178611 RP004195165 RP004218086 RP004223006 RP004224106 RP004225117 RP004248824 RP004249168 RP004252036 RP004353889 RP004386344 RP004390547 RP004455855 RP004460125 RP004473779 RP004481948 RP004484281 RP004494786 RP004528805 RP004541612 RP004551886
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0003984 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38657
Antibody Information
	polyclonal (Schnepp et al., 1996, Schnepp et al., 1996)
Other Information
Discoverer
	Puro, 1960.
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: vn CG10491 (Gabrielian, 1999.11)
Source for database merge of
Additional comments	Map position and phenotype suggest of "vn1" suggests a possible relationship to "Vn1", but allelism has not been tested as "Vn1" is no longer available. (Puro, 1982) Six alleles (Diaz-Benjumea et al., 1989). Not tested for allelism with Vn, a dominant mutant of similar map position and phenotype which has been lost.
Other Comments
	rho, sim and vn are required for the formation of the brain lateral to the foregut cells. (Page, 2003) The vn/Egfr pathway may be directly required for development of the notum by activating notum specifying genes and indirectly controlling wing outgrowth through regulation of ap. (Wang et al., 2000) hh activates vn expression. This activation is mediated through the gene ci. (Amin et al., 1999) vn is required for the development of some, but not all, of the hh-dependent medial head structures. (Amin et al., 1999) vn has a minor role in the embryo and does not induce Egfr target genes such as argos and pnt in the embryo. vn has a major role in wing development and vn/Egfr signal is a potent inducer of Egfr target genes in the wing disc. (Wessells et al., 1999) EGF domain swapping experiments of vn, spi and argos demonstrate that the EGF domain is the key determinant that gives Egfr inhibitors and activators their distinct properties. (Schnepp et al., 1998) vn is the activating ligand of Egfr in the midgut. vn plays a permissive role in the induction of the endoderm by dpp and wg, which in turn up-regulate vn expression in the midgut mesoderm in two regions overlapping the dpp sources. (Szuts et al., 1998) vn plays a role in autocrine Egfr signaling. (Wasserman and Freeman, 1998) vn is required to complement spi in the development of a subset of muscle precursors whose differentiation depends on Egfr activity. (Yarnitzky et al., 1998) Genetic combinations with mutants of nub cause additive phenotypes. (Cifuentes and Garcia-Bellido, 1997) A screen to isolate mutations that cause dominant enhancement of wing vein phenotypes associated with Egfr recovered mutations in vn. (Price et al., 1997) In vivo culture of mutant discs from genotypes that are normally embryonic lethal demonstrates vn is essential for wing disc growth. (Simcox, 1997) The molecular signal for terminal differentiation of tendon cells is secreted vn protein produced by the myotubes. (Yarnitzky et al., 1997) Loss of function mutations in bs are epistatic to loss of function mutations in rho or vn. (Montagne et al., 1996) Molecular and genetic data suggest that vn is linked to the Egfr pathway and encodes a ligand for the Egfr product. (Schnepp et al., 1996) Phenotype and expression analysis show vn has an early role in global proliferation of the wing disc and specific roles in the development of the notum, hinge, longitudinal vein 4 and all intervein regions. (Simcox et al., 1996) Mutant embryos have a phenotype similar to that seen in sr, with abnormal direction of myotubule filopodia. (Yarnitzky and Volk, 1996) Phenotypic analysis suggests vn is a new member of the spi group. (Schnepp et al., 1995) Meiotic location, larval phenotype, clonal behaviour, complementation tests and vn heteroallelic combinations suggest vn and vn are allelic. (Garcia-Bellido et al., 1994) Genetic mosaics demonstrate that cell proliferation is reduced in all regions of the wing blade in a local autonomous way, the effects are more extreme when clones occupy intervein regions bordering veins. Clones also have nonautonomous effects in the proliferation of wild type cells in the same wing, these effects are more extreme in double mutants with rho. (Garcia-Bellido et al., 1994) Mutations in vn cause pleiotropic phenotypes in embryonic patterns and affect several longitudinal veins. (Diaz-Benjumea and Garcia-Bellido, 1990) ve, vn, ci, cg, svs, ast, H, Vno and vvl belong to the vein phenotypic group (Puro, 1982, Droso. Info. Serv. 58:205--208) within the 'lack-of-vein' mutant class. Loss-of-function alleles at these loci remove stretches of veins in two or more longitudinal veins. Double mutations within members of this group remove all veins, have smaller, slightly lanceolate wings, no sensilla and extra chaetae. Some alleles are embryonic lethal. (Diaz-Benjumea et al., 1989) Homozygous ddd larvae perish between the first larval instar and the prepupal stage; dorsal thoracic imaginal discs, i.e. of the pronotum, mesonotum and metanotum reduced to 3% or less of normal size; all other imaginal discs develop normally. Mutant larvae support the growth of wild-type wing discs; mutant wing discs show very little development in wild-type larval. Mutant cells develop normally in wing discs that contain mixtures of mutant and wild-type cells, as produced by nuclear or cellular transplantation into blastoderms or by somatic exchange. Mutant leg discs transplanted into wild-type hosts can transdetermine to wing development. Studies of temperature-sensitive genotypes indicate that vn+ product is not required for normal wing development during embryogenesis. No evidence for a maternal effect in either conditional mutants raised under permissive conditions and switched to restrictive temperatures or in germ-line-transplants of mutant cells into wild-type hosts.
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079218 NM_001014565 RefSeq (Proteins) • NP_523942 NP_001014565 DDBJ / EMBL / GenBank • AAC47293 AAF50739 AAF50739.2 AAX52759 AQ034078 AY863796 AY863797 AY863798 AY863799 AY863800 AY863801 AY863802 AY863803 AY863804 AY863805 AY863806 AY863807 AY863808 AY863809 AY863810 AY863811 AY863812 AY863813 AY863814 CZ478996 CZ480937 CZ480938 U67935 Entrez Gene - A searchable database of RefSeq genes. • 38657 UniProtKB/Swiss-Prot • Q94918
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Epidermal growth factor-like, type 3 (IPR000742) Immunoglobulin subtype 2 (IPR003598) Immunoglobulin-like (IPR007110) EGF-like region, conserved site (IPR013032) Epidermal growth factor-like (IPR006210) Immunoglobulin-like fold (IPR013783) Immunoglobulin I-set (IPR013098)
Linkouts
	BioGRID - A database of protein and genetic interactions • 64117 DroID - A comprehensive database of gene and protein interactions. • FBgn0003984 DRSC - Results from RNAi screens. • FBgn0003984 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003984 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10491-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0003984 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38657 InParanoid A subset of ortholog calls from InParanoid. • AAEL012517-PA Aedes aegypti (mosquito) AGAP007110-PA Anopheles gambiae (mosquito) ENSECAP00000018365 Equus caballus (horse) ENSGALP00000039426 Gallus gallus (chicken) ENSP00000239926 Homo sapiens (human) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /torstoll/vein1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38657 modMine - Data generated by the modENCODE project. • FBgn0003984 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB13961 NV17888 LH13695 ISCW006065 FBgn0237844 FBgn0218660 FBgn0200534 FBgn0184895 FBgn0168823 JGI_V11_98516 FBgn0070407 FBgn0158999 FBgn0134795 FBgn0124505 FBgn0106368 FBgn0098516 FBgn0087481 CPIJ004964 CPIJ004965 CPIJ004966 BGIBMGA012742 ACYPI34621 ACYPI34620 GB18384 AGAP007110 AAEL012979 AAEL012977 AAEL012517 PHUM059700 PHUM060010 GLEAN_14604 REDfly - A database of transcriptional regulatory elements. • FBgn0003984
Synonyms & Secondary IDs ( 18 )
Reported As
Symbol Synonym	CG10491 (Keleman et al., 2009.8.5) CT29452 (Hynes and Zhao, 2000, Hynes and Zhao, 2000) ddd (Cohen, 1993, ) Dm vn (Crocker et al., 2008) l(3)10567   l(3)10568   l(3)ddd   l(3)L6A (Wurst et al., 1984) l(3)rF264   l(3)vn10567 (Jin et al., 2005) P1749 (Yarnitzky and Volk, 1996) vein (Griffiths and Hidalgo, 2004) Vein (McDonald et al., 2005, Brower, 2003, Beck and Fainzilber, 2002, Klambt, 2000) vn (Ramos and Mohler, 2006, Parker, 2006, Zinzen et al., 2006, Charroux et al., 2006, Zeitlinger et al., 2007, Sandmann et al., 2007, Stathopoulos and Levine, 2005, Galindo et al., 2005, Christensen et al., 2008.4.15, Christensen et al., 2008.4.15, Christensen et al., 2008.4.15, Macdonald and Long, 2005, Markstein et al., 2004, Choksi et al., 2006, Rafel and Milán, 2008, Huh et al., 2009, Angulo et al., 2004, Schlesinger et al., 2004, Terriente-Félix and de Celis, 2009, Muse et al., 2007, Oishi et al., 2006, Oishi et al., 2009, Grieder et al., 2009, Zhang et al., 2009, Klein et al., 2010, Guichard et al., 2006, Foley et al., 2010, Rendina et al., 2010, Chang et al., 2001, Bosch et al., 2010, Beltran et al., 2007, Jiang and Edgar, 2009, Ajuria et al., 2011, Hogan et al., 2011, Jiang et al., 2011, Wang et al., 2011) Vn (Roch et al., 2002, Cavodeassi et al., 2001, Montell, 2006, Ren et al., 2010) wvn
Name Synonym	defective dorsal discs   Dm vein (Crocker et al., 2008) vein (Pallavi et al., 2006, Galindo et al., 2005, Letizia et al., 2007, Takanaka and Courey, 2005, Markstein et al., 2004, Rafel and Milán, 2008, Foronda et al., 2009, Santos et al., 2005, Oishi et al., 2006, Zhang et al., 2009, Klein et al., 2010, Jiang and Edgar, 2009, Buchon et al., 2010, Ajuria et al., 2011, Jiang et al., 2011, Wang et al., 2011, Ozdemir et al., 2011) Vein (McDonald et al., 2006, Buchon et al., 2009, Ren et al., 2010)
Secondary FlyBase IDs
	FBgn0001609 FBgn0002436 FBgn0010946 FBgn0011493
References ( 265 )
Generate a list of	All references relating to this gene ( 265 )
List References by type	Research paper  ( 146 ) Supplementary material  ( 5 ) Review  ( 52 ) Personal communication to FlyBase  ( 13 ) Abstract  ( 39 ) FlyBase analysis  ( 1 ) Curated genome annotation  ( 1 ) Protein sequence record  ( 2 ) DNA/RNA sequence record  ( 1 ) Computer file  ( 3 ) Book  ( 1 )
Recent research papers ( 15 )
	Ajuria et al., 2011, Development 138(5): 915--924 Capicua DNA-binding sites are general response elements for RTK signaling in Drosophila. [FBrf0212975] Baycin-Hizal et al., 2011, J. Proteome Res. 10(6): 2777--2784 GlycoFly: A Database of Drosophila N-linked Glycoproteins Identified Using SPEG-MS Techniques. [FBrf0213834] Casso et al., 2011, Genetics 187(2): 485--499 A Novel Interaction Between hedgehog and Notch Promotes Proliferation at the Anterior-Posterior Organizer of the Drosophila Wing. [FBrf0212986] Gabilondo et al., 2011, Mech. Dev. 128(3-4): 208--221 A targeted genetic screen identifies crucial players in the specification of the Drosophila abdominal Capaergic neurons. [FBrf0213290] Hogan et al., 2011, PLoS Genet. 7(2): e1001305 Two frizzled planar cell polarity signals in the Drosophila wing are differentially organized by the fat/dachsous pathway. [FBrf0213159] Jiang et al., 2011, Cell Stem Cell 8(1): 84--95 EGFR/Ras/MAPK Signaling Mediates Adult Midgut Epithelial Homeostasis and Regeneration in Drosophila. [FBrf0212694] Ozdemir et al., 2011, Genome Res. 21(4): 566--577 High resolution mapping of Twist to DNA in Drosophila embryos: Efficient functional analysis and evolutionary conservation. [FBrf0213359] Wang et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(27): 11139--11144 Sexually dimorphic regulation of the Wingless morphogen controls sex-specific segment number in Drosophila. [FBrf0214239] Xu et al., 2011, Dev. Biol. 354(1): 31--43 EGFR, Wingless and JAK/STAT signaling cooperatively maintain Drosophila intestinal stem cells. [FBrf0213634] Bosch et al., 2010, Int. J. Dev. Biol. 54(8-9): 1241--1250 Leg regeneration in Drosophila abridges the normal developmental program. [FBrf0211809] Buchon et al., 2010, BMC Biol. 8: 152 Drosophila EGFR pathway coordinates stem cell proliferation and gut remodeling following infection. [FBrf0212840] Foley et al., 2010, Biol. Letts 6(1): 102--105 Does segregating variation in sexual or microhabitat preferences lead to non-random mating within a population of Drosophila melanogaster? [FBrf0209672] Klein et al., 2010, Dev. Biol. 337(2): 458--470 The proprioceptive and contractile systems in Drosophila are both patterned by the EGR family transcription factor Stripe. [FBrf0209777] Ren et al., 2010, Proc. Natl. Acad. Sci. U.S.A. 107(49): 21064--21069 Hippo signaling regulates Drosophila intestine stem cell proliferation through multiple pathways. [FBrf0212502] Rendina et al., 2010, Genetics 186(1): 167--181 Bap170, a Subunit of the Drosophila PBAP Chromatin Remodeling Complex, Negatively Regulates the EGFR Signaling. [FBrf0211845] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...