wind
Please see the JBrowse view of Dmel\wbl for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.50
1.0 (northern blot)
257 (aa); 29 (kD predicted)
Homodimer. Interacts directly with pip.
The CXXC motif was initially thought to constitute the active site of a potential protein disulfide isomerase activity. However, such motif is not essential, suggesting that it has no disulfide isomerase activity. Its precise role remains unclear.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\wbl using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: reported as head epidermis primordium
Comment: reported as head epidermis primordium
Comment: reported as head epidermis primordium
Comment: reported as salivary gland primordium
wbl transcripts are detected in RNA from early embryos, adult males, and ovaries on northern blots but not in RNA from female carcasses. wbl transcripts are detected by in situ hybridization in follicle cells of stage 8-10 egg chambers. Only follicle cells that are located over the oocyte express wbl transcripts. The transcripts appear to be concentrated within the follicle cells in the side facing the oocyte.
JBrowse - Visual display of RNA-Seq signals
View Dmel\wbl in JBrowsePlease Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
wbl encodes a putative resident protein of the endoplasmic reticulum.
A follicular cell marker system that yields a visible phenotype within the mature egg shell allows direct comparison of a clone and its effect on the dorsal ventral pattern of the embryos. Wild type wbl activity is required only in the cells on the ventral side of the follicular epithelium and is restricted along the A/P axis.
Double mutant combinations of wbl with ea alleles demonstrate that spatial regulation of ea activity by localized zymogen activation is a key initial event in defining the polarity of the dorsal-ventral embryonic pattern.
Analysis of mosaic females indicates that the expression of ndl, pip and wbl is required in the somatic tissue, in the follicle cells that surround the oocyte, for the production of embryos with the correct dorsoventral axis.
Mutation in wbl results in a maternal effect phenotype with defects during the early stages of gastrulation and defects in the dorsoventral axis; embryos derived from homozygous females are dorsalised.
Maternal expression of wbl, one of the 'dorsal group' genes, is required for the production of all lateral and ventral pattern elements. In the absence of the wild-type allele, all embryonic cells differentiate dorsal epidermis.
One allele.
Source for identity of: wbl CG7225
