Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\wrl using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\wrl in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
wrl is required for post-meiotic stages of spermatid differentiation and is haploinsufficient for male fertility. Phenotypic analysis of mutant alleles suggests that the wrl gene product is required for the correct architecture of the sperm flagellar axoneme.
Male sterile. Males homozygous for wrl have defects in post-meiotic spermatid differentiation, including disordered spermatid components, disrupted flagellar axonemes and axonemes lacking one or both central pair microtubules. Axonemes commonly show defects in the structure of the outer doublet or accessory microtubules. Onion stage early spermatids normal, indicating normal meiosis. Homozygous viable and female fertile. wrl acts as a dominant enhancer of tubulin mutants. Alleles obtained by reverting the failure of wrl to complement βTub85Dn are dominant male sterile, but are suppressed (restored to fertility) when heterozygous with some mutant alleles of αTub84B or βTub85D. A deficiency for 88C2-E3 generated using Tp(3;1)kar5l and Tp(3;2)ry+ is semidominant male sterile, but is restored to fertility when heterozygous with βTub85Dn Together these results indicate that wrl may be responsible for haploinsufficiency for male fertility located in polytene interval 88C-D. The genetic interactions between mutations in wrl and tubulin mutants indicates that the wrl gene product could play a role in microtubule function.