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Gene Dmel\Yp1

General Information
Symbol	Dmel\Yp1	Species	D. melanogaster
Name	Yolk protein 1	Annotation symbol	CG2985
Feature type	protein_coding_gene	FlyBase ID	FBgn0004045
Gene Model Status	Current	Stock availability	3 publicly available
Also Known As	YP, yp-1, YPI, fs(1)1163
Genomic Location
Chromosome (arm)	X	Recombination map	1-30
Cytogenetic map	9A5-9A5	Sequence location	X:9,947,885..9,949,531 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Yolk protein 1 is referred to in FlyBase by the symbol Dmel\Yp1 (CG2985, FBgn0004045). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: structural molecule activity. Based on sequence similarity, it is predicted to be involved in the biological process: vitellogenesis. 34 alleles are reported. The phenotypes of these alleles are annotated with: adult fat body; mesothoracic tergum. It has one annotated transcript and one annotated polypeptide. Protein features are: Lipase; Lipase, N-terminal. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely high expression to a trough of extremely low expression. Peak expression observed in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, adult hindgut, adult heart, adult fat body, adult female reproductive system, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult salivary gland. Comments on Affy2 ProbeSet: ProbeSet 1629545_at partially aligns to an exonic region of the only FlyBase-annotated transcript isoform of Yp1: 9 out of 14 probes fall into this exonic region. Gene sequence location is X:9947885..9949531.
User Contributed Data
	Beta version, feedback welcome
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	Yp1 Structural gene for the yolk protein YP1 found in recently-emerged female flies. Protein migrates at different rates in SDS-polyacrylamide gels when encoded by the electrophoretic variants Yp1F (fast) and Yp1S (slow), alleles that are female fertile and produce normal amounts of YP1. Yp1ts1, which maps near the Yp1 locus and is believed to be an allele, produces a slow-migrating translation product that is present in reduced amounts in the hemolymph and the ovaries (Bownes and Hodson, 1980); this mutant is female sterile.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 9A5-9A5
Experimentally Determined Cytological Location
Cytogenetic map Notes References 8F-9A   (determined by in situ hybridisation)   (Vieira et al., 1997) 9A-9A   (determined by in situ hybridisation)   (Yan et al., 1987) 9A-9B   (determined by in situ hybridisation)   (Riddell et al., 1981) 8F-9A   (determined by in situ hybridisation)   (Barnett et al., 1980)
Experimentally Determined Recombination Data
Location	1-30
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Yp1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.40 Low-frequency RNA-Seq exon junction(s) not annotated. Gene model reviewed during 5.49
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Yp1-RA FBtr0071419  NM_078548   1570   439
Additional Transcript Data & Comments
Reported size (kB)	1.559 (sequence analysis) (Mien-Chie and Wensink, 1981) 1.6 (sequence analysis) (Hovemann et al., 1981) 1.6 (northern blot) (Hung et al., 1982)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Yp1-PA   FBpp0071354   48.7   439   7.86     NP_511103   AAF46548
Additional Polypeptide Data & Comments
Reported size (kDa)	439 (aa); 48.7 (kD predicted) (Hovemann et al., 1981) 439 (aa); 48.3 (kD predicted) (Mien-Chie and Wensink, 1981)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Lipase (IPR000734) Lipase, N-terminal (IPR013818)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA567306   AA567744   AA567747   AA567806   AA696308   AA697505   AA697607   AA697853   AA698059   AA698135   AA698269   AA698292   AA698399   AA698429   AA698471   AA698472   AA698577   AA698655   AA698706   AA698743   AA698785   AA698922   AE014298 AAF46548   AI061852   AI062029   AI062054   AI062142   AI062200   AI062236   AI062304   AI062332   AI062508   AI062588   AI062626   AI062726   AI062795   AI062911   AI063074   AI063076   AI063137   AI063328   AI063337   AI063411   AI063464   AI063498   AI063571   AI063619   AI063745   AI063756   AI063795   AI063837   AI063880   AI063981   AI063984   AI064054   AI064080   AI064145   AI064254   AI064662   AI106626   AI106655   AI106765   AI106805   AI106864   AI107038   AI107044   AI107123   AI107134   AI107305   AI107462   AI107475   AI107614   AI107794   AI107799   AI107927   AI108081   AI108157   AI108255   AI108271   AI108394   AI108487   AI108560   AI108562   AI108634   AI108660   AI108669   AI108732   AI108842   AI108902   AI108956   AI108965   AI109000   AI109242   AI109306   AI109373   AI109396   AI109437   AI109502   AI109511   AI109570   AI109628   AI109727   AI109917   AI110028   AI110055   AI110200   AI113407   AI113569   AI113640   AI113726   AI113740   AI113809   AI113888   AI114141   AI114165   AI114230   AI114264   AI114370   AI133833   AI134064   AI134149   AI134174   AI134195   AI134216   AI134326   AI134406   AI134417   AI134538   AI134541   AI134570   AI134631   AI134668   AI134716   AI134830   AI134882   AI134931   AI135135   AI135161   AI135190   AI135203   AI135523   AI135598   AI135653   AI135675   AI135728   AI237935   AI237946   AI238125   AI238260   AI238480   AI238554   AI238747   AI238784   AI238877   AI239048   AI239105   AI239250   AI292547   AI292549   AI292618   AI292624   AI292659   AI292786   AI292839   AI292864   AI292867   AI292869   AI292933   AI292969   AI292975   AI293089   AI293148   AI293150   AI293161   AI293248   AI293275   AI293325   AI293341   AI386485   AI386634   AI387041   AI387117   AI387153   AI387166   AI387176   AI387195   AI387263   AI387306   AI387424   AI387440   AI387548   AI387640   AI387749   AI387778   AI387793   AI387812   AI387867   AI387887   AI387929   AI387972   AI387975   AI387987   AI387998   AI388025   AI388070   AI388077   AI388130   AI388146   AI388191   AI388276   AI388299   AI388370   AI388371   AI388402   AI388407   AI388448   AI388454   AI388487   AI388585   AI388728   AI388770   AI388910   AI388925   AI388940   AI388946   AI388991   AI389021   AI389206   AI389235   AI389314   AI389322   AI389385   AI389429   AI389507   AI389654   AI389669   AI389688   AI389800   AI389822   AI389850   AI389857   AI389874   AI389986   AI402304   AI402442   AI402467   AI402540   AI402549   AI402568   AI402638   AI402639   AI402669   AI402726   AI402775   AI402785   AI402812   AI402857   AI402865   AI402878   AI402907   AI402917   AI402949   AI403005   AI403063   AI403133   AI403136   AI403151   AI403217   AI403292   AI403582   AI403594   AI403615   AI403729   AI403808   AI403893   AI403992   AI404041   AI404154   AI404263   AI404304   AI404329   AI404478   AI404501   AI404591   AI404724   AI404821   AI404905   AI405006   AI405232   AI405246   AI405268   AI405321   AI405381   AI405417   AI405517   AI405618   AI405669   AI405706   AI405709   AI405890   AI405999   AI406104   AI406240   AI513524   AI513686   AI513837   AI514113   AI514144   AI516837   AI516918   AI516944   AI517079   AI517168   AI517321   AI517337   AI517477   AI517514   AI517664   AI517695   AI517769   AY075560 AAL68367   BG632033   BG632337   BG632936   BI353833   BI354936   BI564244   BI564590   BI564980   BI566612   BI566855   BI573296   BI573297   BI574154   BI576114   BI583415   BI583635   BI586167   BI586170   BI586272   BI586460   BI587089   BI587641   BI587868   BI588626   BI591175   BI591950   BI591989   BI592189   BI593420   BI605268   BI605968   BI606356   BI607965   BI608552   BI608825   BI609787   BI612762   BI612872   BI612888   BI613461   BI613964   BI614981   BI620187   BI620271   BI621102   BI621136   BI621252   BI621318   BI622332   BI622663   BI623312   BI623446   BI623944   BI624004   BI624031   BI624969   BI625475   BI625500   BI625530   BI625821   BI626509   BI626864   BI627163   BI628890   BI629872   BI630225   BI630577   BI630699   BI631137   BI631282   BI631560   BT023849   CO189181   CO189185   CO189570   CO274014   CO284448   CO285453   CO297868   CO299126   CO299513   CO303931   CO306374   CO312828   CO315836   EC054247   EC060174   EC072038   EC080762   EC083074   EC085348   EC085554   EC089479   EC195364   EC213330   EC215231   EC221751   EC228181   EC229816   EC234181   EC249752   EL870561   EL870562   EL873203   EL874039   EL876189   EL876258   EL876332   EL876406   EL876992   EL877073   EL877182   EL879000   EL881857   EL881975   EL882086   EL882207   EL883223   EL883454   EL884055   EL886338   EL886448   EL886512   EL886566   EL886619   EL886667   EL886728   ES691194   ES691307   ES691704   ES691823   ES694357   ES694840   ES694949   ES694978   ES694982   EV574882   EV575223   EV575662   EV575721   EV576022   EV576037   EV576258   EV576512   EV576529   EV576689   EV576750   EV577080   EV577306   EV577336   EV577403   EV577404   EV577616   EV578037   EV578166   EV578331   EV578584   EV578606   EV578781   EV578793   EV578843   EV578986   EV579115   EV579305   EV579454   EV579522   EV579588   EV579659   EV579782   EV579817   EV579825   EV579899   EV579965   EV579972   EV580053   EV580068   EV580132   EV580388   EV580487   EV580507   EV580823   EV581013   EV581061   EV581123   EV581152   EV581207   EV581290   EV581301   EV581346   EV581437   EV581660   EV581698   EV581729   EV581771   EV582103   EV582151   EV582413   EV582427   EV582511   EV582608   EV582732   EV582806   EV582874   EV583008   EV583855   EV583945   EV584010   EV584181   EV584412   EV584647   EV584657   EV584736   EV584798   EV585024   EV585062   EV585100   EV585298   EV585342   EV585428   EV585564   EV585883   EV585908   EV586389   EV586527   EV586552   EV586760   EV587700   EV587733   EV588214   EV588431   EV588671   EV588710   EV588865   EV589511   EV589594   EV589662   EV589966   EV590160   EV590252   EV590282   EV590369   EV590382   EV590439   EV590564   EV591346   EV591405   EV591773   EV591939   EV591980   EV591986   EV592075   EV592586   EV592610   EV593462   EV593639   EV593673   EV593733   EV594275   EV594292   EV594404   EV594628   EV594636   EV594896   EV595283   EV595351   EV595445   EV595989   EV596165   EV596282   EV596569   EV596645   EV596865   EV597166   EV597278   EV597630   EV597667   EV597965   EV597973   EV597998   EV598033   EV598040   EV598432   EV598556   EV598611   EV599178   EV599206   EV599293   EV600191   EV600268   EV600699   EV600703   V00248 CAA23502   X01524 CAA25709
UniProtKB/Swiss-Prot	P02843
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References protein binding site FBsf0000160688 X:9,947,609..9,947,638 evidence=experimental bound_moiety=dsx-F-XP bound_moiety=dsx-M-XP (Bergman et al., 2005, Burtis et al., 1991) protein binding site FBsf0000160689 X:9,947,619..9,947,638 bound_moiety=slbo-XP evidence=experimental (Falb and Maniatis, 1992, Bergman et al., 2005) protein binding site FBsf0000160690 X:9,947,591..9,947,609 evidence=experimental bound_moiety=slbo-XP (An and Wensink, 1995, Bergman et al., 2005) protein binding site FBsf0000160691 X:9,947,666..9,947,676 bound_moiety=slbo-XP evidence=experimental (Bergman et al., 2005, Falb and Maniatis, 1992) protein binding site FBsf0000160692 X:9,947,653..9,947,670 evidence=experimental bound_moiety=dsx-M-XP bound_moiety=dsx-F-XP (Burtis et al., 1991, Bergman et al., 2005) protein binding site FBsf0000160693 X:9,947,585..9,947,603 bound_moiety=dsx-M-XP bound_moiety=dsx-F-XP evidence=experimental (Burtis et al., 1991, Bergman et al., 2005) protein binding site FBsf0000160694 X:9,947,727..9,947,738 bound_moiety=srp-XP evidence=experimental (Lossky and Wensink, 1995, Bergman et al., 2005) protein binding site FBsf0000160695 X:9,947,581..9,947,598 bound_moiety=Aef1-XP evidence=experimental (Falb and Maniatis, 1992, Bergman et al., 2005) regulatory region FBsf0000435385 X:9,946,801..9,947,011 evidence=Reporter construct (in vivo) (Logan and Wensink, 1990, Halfon, 2012.6.19) regulatory region FBsf0000435491 X:9,946,710..9,947,011 evidence=Reporter construct (in vivo) (Logan and Wensink, 1990, Halfon, 2012.6.19) regulatory region FBsf0000435508 X:9,946,562..9,947,927 evidence=Reporter construct (in vivo) (Logan and Wensink, 1990, Halfon, 2012.6.19) regulatory region FBsf0000435779 X:9,946,803..9,946,951 evidence=Reporter construct (in vivo) (Logan and Wensink, 1990, Halfon, 2012.6.19) regulatory region FBsf0000436019 X:9,946,564..9,946,665 evidence=Reporter construct (in vivo) (Logan and Wensink, 1990, Halfon, 2012.6.19) regulatory region FBsf0000436332 X:9,946,668..9,947,698 evidence=Reporter construct (in vivo) (Logan and Wensink, 1990, Halfon, 2012.6.19) regulatory region FBsf0000436341 X:9,947,562..9,947,687 evidence=Reporter construct (in vivo) (Garabedian et al., 1986, Halfon, 2012.6.19) regulatory region FBsf0000436585 X:9,946,999..9,947,564 evidence=Reporter construct (in vivo) (Garabedian et al., 1986, Halfon, 2012.6.19) regulatory region FBsf0000436596 X:9,946,712..9,946,951 evidence=Reporter construct (in vivo) (Logan and Wensink, 1990, Halfon, 2012.6.19)
External Data
Linkouts
Crossreferences	EPD - Eukarytoic Promoter Database, an annotated collection of POL II promoters • 07022 07023
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 11 -- 12   antennal primordium   (Fisher et al., 2012) atrium | precursor   (Fisher et al., 2012) Comment:reported as atrium primordium embryonic stage 13 -- 16   atrium   (Fisher et al., 2012) embryonic antennal sense organ   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
lipid particle inferred from direct assay (Cermelli et al., 2006) microtubule associated complex inferred from direct assay (Hughes et al., 2008)
Expression Deduced from Reporters
Reporter: P{Yp(1+2)M13} Stage Tissue/Position (including subcellular localization) Reference adult stage | female   organism   (Garabedian et al., 1986) Reporter: P{Yp1-lacZ.G1} Stage Tissue/Position (including subcellular localization) Reference adult stage | female   adult fat body   (Garabedian et al., 1986) Reporter: P{Yp1-lacZ.G2} Stage Tissue/Position (including subcellular localization) Reference adult stage | female   adult fat body   (Garabedian et al., 1986) Reporter: P{Yp1-lacZ.G4a} Stage Tissue/Position (including subcellular localization) Reference adult stage | female   adult fat body   (Garabedian et al., 1986) Reporter: P{Yp1-lacZ.G4b} Stage Tissue/Position (including subcellular localization) Reference adult stage | female   adult fat body   (Garabedian et al., 1986) Reporter: P{Yp1-lacZ.G5a} Stage Tissue/Position (including subcellular localization) Reference adult stage | female   adult fat body   (Garabedian et al., 1986) Reporter: P{Yp1-lacZ.G5b} Stage Tissue/Position (including subcellular localization) Reference adult stage | female   adult fat body   (Garabedian et al., 1986) Reporter: P{Yp1.M13.G1}P{Yp1.M13.G3} Stage Tissue/Position (including subcellular localization) Reference adult stage | female   adult fat body   (Garabedian et al., 1985) organism   (Garabedian et al., 1986) Reporter: P{Yp1.M13.G2} Stage Tissue/Position (including subcellular localization) Reference adult stage | female   organism   (Garabedian et al., 1986) Reporter: P{Yp1.M13.G1}P{Yp1.M13.G3} Stage Tissue/Position (including subcellular localization) Reference adult stage | female   adult fat body   (Garabedian et al., 1985) organism   (Garabedian et al., 1986)
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, adult hindgut, adult heart, adult fat body, adult female reproductive system, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult salivary gland. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    7.85 Larval Midgut    51.2 Larval Hindgut    15.4 Larval Malpighian Tubules    3.1 Larval Fat Body    7.6 Larval Salivary Gland    10.2 Larval Trachea    687.05 Larval Carcass    16.25 Adult Head    5507.4 Adult Eye    8882.275 Adult Brain    2587.9 Adult Thoracic-Abdominal Ganglion    3487 Adult Crop    3253.3 Adult Midgut    71.1 Adult Hindgut    4508.9 Adult Malpighian Tubules    1568.1 Adult Fat Body    4528.5 Adult Salivary Gland    305.9 Adult Heart    8558.375 Adult VirginFemale Spermatheca    4194.1 Adult InseminatedFemale Spermatheca    4633 Adult Ovary    2892.5 Adult Testis    4.6 Adult Male Accessory Gland    13 Adult Carcass    7667.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    7.85 Larval Midgut    51.2 Larval Hindgut    15.4 Larval Malpighian Tubules    3.1 Larval Fat Body    7.6 Larval Salivary Gland    10.2 Larval Trachea  (687.05) Larval Carcass    16.25 Adult Head  (5507.4) Adult Eye  (8882.275) Adult Brain  (2587.9) Adult Thoracic-Abdominal Ganglion  (3487) Adult Crop  (3253.3) Adult Midgut    71.1 Adult Hindgut  (4508.9) Adult Malpighian Tubules  (1568.1) Adult Fat Body  (4528.5) Adult Salivary Gland    305.9 Adult Heart  (8558.375) Adult VirginFemale Spermatheca  (4194.1) Adult InseminatedFemale Spermatheca  (4633) Adult Ovary  (2892.5) Adult Testis    4.6 Adult Male Accessory Gland    13 Adult Carcass  (7667.7) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    7.85 Larval Midgut    51.2 Larval Hindgut    15.4 Larval Malpighian Tubules    3.1 Larval Fat Body    7.6 Larval Salivary Gland    10.2 Larval Trachea    687.05 Larval Carcass    16.25 Adult Head  (5507.4) Adult Eye  (8882.275) Adult Brain  (2587.9) Adult Thoracic-Abdominal Ganglion  (3487) Adult Crop  (3253.3) Adult Midgut    71.1 Adult Hindgut  (4508.9) Adult Malpighian Tubules  (1568.1) Adult Fat Body  (4528.5) Adult Salivary Gland    305.9 Adult Heart  (8558.375) Adult VirginFemale Spermatheca  (4194.1) Adult InseminatedFemale Spermatheca  (4633) Adult Ovary  (2892.5) Adult Testis    4.6 Adult Male Accessory Gland    13 Adult Carcass  (7667.7) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    7.85 Larval Midgut    51.2 Larval Hindgut    15.4 Larval Malpighian Tubules    3.1 Larval Fat Body    7.6 Larval Salivary Gland    10.2 Larval Trachea    687.05 Larval Carcass    16.25 Adult Head    5507.4 Adult Eye    8882.275 Adult Brain    2587.9 Adult Thoracic-Abdominal Ganglion    3487 Adult Crop    3253.3 Adult Midgut    71.1 Adult Hindgut    4508.9 Adult Malpighian Tubules    1568.1 Adult Fat Body    4528.5 Adult Salivary Gland    305.9 Adult Heart    8558.375 Adult VirginFemale Spermatheca    4194.1 Adult InseminatedFemale Spermatheca    4633 Adult Ovary    2892.5 Adult Testis    4.6 Adult Male Accessory Gland    13 Adult Carcass    7667.7 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    7.85 Larval Midgut    51.2 Larval Hindgut    15.4 Larval Malpighian Tubules    3.1 Larval Fat Body    7.6 Larval Salivary Gland    10.2 Larval Trachea    687.05 Larval Carcass    16.25 Adult Head    5507.4 Adult Eye    8882.275 Adult Brain    2587.9 Adult Thoracic-Abdominal Ganglion    3487 Adult Crop    3253.3 Adult Midgut    71.1 Adult Hindgut    4508.9 Adult Malpighian Tubules    1568.1 Adult Fat Body    4528.5 Adult Salivary Gland    305.9 Adult Heart    8558.375 Adult VirginFemale Spermatheca    4194.1 Adult InseminatedFemale Spermatheca    4633 Adult Ovary    2892.5 Adult Testis    4.6 Adult Male Accessory Gland    13 Adult Carcass    7667.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    7.85 Larval Midgut    51.2 Larval Hindgut    15.4 Larval Malpighian Tubules    3.1 Larval Fat Body    7.6 Larval Salivary Gland    10.2 Larval Trachea  687.05 Larval Carcass    16.25 Adult Head  (5507.4) Adult Eye  (8882.275) Adult Brain  (2587.9) Adult Thoracic-Abdominal Ganglion  (3487) Adult Crop  (3253.3) Adult Midgut    71.1 Adult Hindgut  (4508.9) Adult Malpighian Tubules  (1568.1) Adult Fat Body  (4528.5) Adult Salivary Gland    305.9 Adult Heart  (8558.375) Adult VirginFemale Spermatheca  (4194.1) Adult InseminatedFemale Spermatheca  (4633) Adult Ovary  (2892.5) Adult Testis    4.6 Adult Male Accessory Gland    13 Adult Carcass  (7667.7) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    7.85 Larval Midgut    51.2 Larval Hindgut    15.4 Larval Malpighian Tubules    3.1 Larval Fat Body    7.6 Larval Salivary Gland    10.2 Larval Trachea    687.05 Larval Carcass    16.25 Adult Head  (5507.4) Adult Eye  (8882.275) Adult Brain  (2587.9) Adult Thoracic-Abdominal Ganglion  (3487) Adult Crop  (3253.3) Adult Midgut    71.1 Adult Hindgut  (4508.9) Adult Malpighian Tubules  1568.1 Adult Fat Body  (4528.5) Adult Salivary Gland    305.9 Adult Heart  (8558.375) Adult VirginFemale Spermatheca  (4194.1) Adult InseminatedFemale Spermatheca  (4633) Adult Ovary  (2892.5) Adult Testis    4.6 Adult Male Accessory Gland    13 Adult Carcass  (7667.7) Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    7.85 Larval Midgut    51.2 Larval Hindgut    15.4 Larval Malpighian Tubules    3.1 Larval Fat Body    7.6 Larval Salivary Gland    10.2 Larval Trachea    687.05 Larval Carcass    16.25 Adult Head    5507.4 Adult Eye    8882.275 Adult Brain    2587.9 Adult Thoracic-Abdominal Ganglion    3487 Adult Crop    3253.3 Adult Midgut    71.1 Adult Hindgut    4508.9 Adult Malpighian Tubules    1568.1 Adult Fat Body    4528.5 Adult Salivary Gland    305.9 Adult Heart    8558.375 Adult VirginFemale Spermatheca    4194.1 Adult InseminatedFemale Spermatheca    4633 Adult Ovary    2892.5 Adult Testis    4.6 Adult Male Accessory Gland    13 Adult Carcass    7667.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    5507.4   NA  Eye    8882.275   NA  Brain    2587.9   7.85  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    3487   NA  Crop    3253.3   no informative data  Midgut    71.1   no informative data  Hindgut    4508.9   3.1  Malpighian Tubules    no informative data   7.6  Fat Body    4528.5   no informative data  Salivary Gland    305.9   NA  Heart    8558.375   no informative data  Trachea    NA   NA  VirginFemale Spermatheca    4194.1   NA  InseminatedFemale Spermatheca    4633   NA  Ovary    2892.5   NA  Testis    4.6   NA  Male Accessory Gland    no informative data   no informative data  Carcass    7667.7 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    13 central nervous system, larvae L3    1 central nervous system, pupae P8    156 head, virgin 1-day female    72425 head, virgin 4-day female    115148 head, virgin 20-day female    119145 head, mated 1-day female    111450 head, mated 4-day female    143098 head, mated 20-day female    162095 head, mated 1-day male    255 head, mated 4-day male    1021 head, mated 20-day male    15 salivary gland, larvae L3 wandering    9 salivary gland, white prepupae    203 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    4137 digestive system, 4-day adult    5170 digestive system, 20-day adult    3939 fat body, larvae L3 wandering    0 fat body, white prepupae    4 fat body, pupae P8    305 carcass, larvae L3 wandering    1830 carcass, 1-day adult    84913 carcass, 4-day adult    116020 carcass, 20-day adult    114795 ovary, virgin 4-day female    1680 ovary, mated 4-day female    2359 testis, mated 4-day male    47 accessory gland, mated 4-day male    144 Expression Level Scale  Moderately high   High   Very high   Extremely high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    13 central nervous system, larvae L3    1 central nervous system, pupae P8  (156) head, virgin 1-day female  (72425) head, virgin 4-day female  (115148) head, virgin 20-day female  (119145) head, mated 1-day female  (111450) head, mated 4-day female  (143098) head, mated 20-day female  (162095) head, mated 1-day male  (255) head, mated 4-day male  (1021) head, mated 20-day male    15 salivary gland, larvae L3 wandering    9 salivary gland, white prepupae  (203) digestive system, larvae L3 wandering    17 digestive system, 1-day adult  (4137) digestive system, 4-day adult  (5170) digestive system, 20-day adult  (3939) fat body, larvae L3 wandering    0 fat body, white prepupae    4 fat body, pupae P8  (305) carcass, larvae L3 wandering  (1830) carcass, 1-day adult  (84913) carcass, 4-day adult  (116020) carcass, 20-day adult  (114795) ovary, virgin 4-day female  (1680) ovary, mated 4-day female  (2359) testis, mated 4-day male  (47) accessory gland, mated 4-day male  (144) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    13 central nervous system, larvae L3    1 central nervous system, pupae P8  (156) head, virgin 1-day female  (72425) head, virgin 4-day female  (115148) head, virgin 20-day female  (119145) head, mated 1-day female  (111450) head, mated 4-day female  (143098) head, mated 20-day female  (162095) head, mated 1-day male  (255) head, mated 4-day male  (1021) head, mated 20-day male    15 salivary gland, larvae L3 wandering    9 salivary gland, white prepupae  (203) digestive system, larvae L3 wandering    17 digestive system, 1-day adult  (4137) digestive system, 4-day adult  (5170) digestive system, 20-day adult  (3939) fat body, larvae L3 wandering    0 fat body, white prepupae    4 fat body, pupae P8  (305) carcass, larvae L3 wandering  (1830) carcass, 1-day adult  (84913) carcass, 4-day adult  (116020) carcass, 20-day adult  (114795) ovary, virgin 4-day female  (1680) ovary, mated 4-day female  (2359) testis, mated 4-day male    47 accessory gland, mated 4-day male  (144) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    13 central nervous system, larvae L3    1 central nervous system, pupae P8    156 head, virgin 1-day female    72425 head, virgin 4-day female    115148 head, virgin 20-day female    119145 head, mated 1-day female    111450 head, mated 4-day female    143098 head, mated 20-day female    162095 head, mated 1-day male    255 head, mated 4-day male    1021 head, mated 20-day male    15 salivary gland, larvae L3 wandering    9 salivary gland, white prepupae    203 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    4137 digestive system, 4-day adult    5170 digestive system, 20-day adult    3939 fat body, larvae L3 wandering    0 fat body, white prepupae    4 fat body, pupae P8    305 carcass, larvae L3 wandering    1830 carcass, 1-day adult    84913 carcass, 4-day adult    116020 carcass, 20-day adult    114795 ovary, virgin 4-day female    1680 ovary, mated 4-day female    2359 testis, mated 4-day male    47 accessory gland, mated 4-day male    144 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    13 central nervous system, larvae L3    1 central nervous system, pupae P8    156 head, virgin 1-day female    72425 head, virgin 4-day female    115148 head, virgin 20-day female    119145 head, mated 1-day female    111450 head, mated 4-day female    143098 head, mated 20-day female    162095 head, mated 1-day male    255 head, mated 4-day male    1021 head, mated 20-day male    15 salivary gland, larvae L3 wandering    9 salivary gland, white prepupae    203 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    4137 digestive system, 4-day adult    5170 digestive system, 20-day adult    3939 fat body, larvae L3 wandering    0 fat body, white prepupae    4 fat body, pupae P8    305 carcass, larvae L3 wandering    1830 carcass, 1-day adult    84913 carcass, 4-day adult    116020 carcass, 20-day adult    114795 ovary, virgin 4-day female    1680 ovary, mated 4-day female    2359 testis, mated 4-day male    47 accessory gland, mated 4-day male    144 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    13 central nervous system, larvae L3    1 central nervous system, pupae P8  (156) head, virgin 1-day female  (72425) head, virgin 4-day female  (115148) head, virgin 20-day female  (119145) head, mated 1-day female  (111450) head, mated 4-day female  (143098) head, mated 20-day female  (162095) head, mated 1-day male  (255) head, mated 4-day male  (1021) head, mated 20-day male    15 salivary gland, larvae L3 wandering    9 salivary gland, white prepupae  (203) digestive system, larvae L3 wandering    17 digestive system, 1-day adult  (4137) digestive system, 4-day adult  (5170) digestive system, 20-day adult  (3939) fat body, larvae L3 wandering    0 fat body, white prepupae    4 fat body, pupae P8  (305) carcass, larvae L3 wandering  (1830) carcass, 1-day adult  (84913) carcass, 4-day adult  (116020) carcass, 20-day adult  (114795) ovary, virgin 4-day female  (1680) ovary, mated 4-day female  (2359) testis, mated 4-day male  (47) accessory gland, mated 4-day male  (144) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    13 central nervous system, larvae L3    1 central nervous system, pupae P8  (156) head, virgin 1-day female  (72425) head, virgin 4-day female  (115148) head, virgin 20-day female  (119145) head, mated 1-day female  (111450) head, mated 4-day female  (143098) head, mated 20-day female  (162095) head, mated 1-day male  (255) head, mated 4-day male  (1021) head, mated 20-day male    15 salivary gland, larvae L3 wandering    9 salivary gland, white prepupae  (203) digestive system, larvae L3 wandering    17 digestive system, 1-day adult  (4137) digestive system, 4-day adult  (5170) digestive system, 20-day adult  (3939) fat body, larvae L3 wandering    0 fat body, white prepupae    4 fat body, pupae P8  (305) carcass, larvae L3 wandering  (1830) carcass, 1-day adult  (84913) carcass, 4-day adult  (116020) carcass, 20-day adult  (114795) ovary, virgin 4-day female  (1680) ovary, mated 4-day female  (2359) testis, mated 4-day male    47 accessory gland, mated 4-day male  (144) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    13 central nervous system, larvae L3    1 central nervous system, pupae P8    156 head, virgin 1-day female    72425 head, virgin 4-day female    115148 head, virgin 20-day female    119145 head, mated 1-day female    111450 head, mated 4-day female    143098 head, mated 20-day female    162095 head, mated 1-day male    255 head, mated 4-day male    1021 head, mated 20-day male    15 salivary gland, larvae L3 wandering    9 salivary gland, white prepupae    203 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    4137 digestive system, 4-day adult    5170 digestive system, 20-day adult    3939 fat body, larvae L3 wandering    0 fat body, white prepupae    4 fat body, pupae P8    305 carcass, larvae L3 wandering    1830 carcass, 1-day adult    84913 carcass, 4-day adult    116020 carcass, 20-day adult    114795 ovary, virgin 4-day female    1680 ovary, mated 4-day female    2359 testis, mated 4-day male    47 accessory gland, mated 4-day male    144 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely high expression to a trough of extremely low expression. Peak expression observed in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    2 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    0 white prepupae new    0 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    4 pupae 3d postWPP    1 pupae 4d postWPP    9 adult male 01day    26 adult male 05day    87 adult male 30day    3 adult female 01day    8190 adult female 05day    14040 adult female 30day    13835 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    2 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    0 white prepupae new    0 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    4 pupae 3d postWPP    1 pupae 4d postWPP    9 adult male 01day  26 adult male 05day  (87) adult male 30day    3 adult female 01day  (8190) adult female 05day  (14040) adult female 30day  (13835) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    2 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    0 white prepupae new    0 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    4 pupae 3d postWPP    1 pupae 4d postWPP    9 adult male 01day    26 adult male 05day    87 adult male 30day    3 adult female 01day  (8190) adult female 05day  (14040) adult female 30day  (13835) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    2 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    0 white prepupae new    0 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    4 pupae 3d postWPP    1 pupae 4d postWPP    9 adult male 01day    26 adult male 05day    87 adult male 30day    3 adult female 01day    8190 adult female 05day    14040 adult female 30day    13835 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    2 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    0 white prepupae new    0 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    4 pupae 3d postWPP    1 pupae 4d postWPP    9 adult male 01day    26 adult male 05day    87 adult male 30day    3 adult female 01day    8190 adult female 05day    14040 adult female 30day    13835 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    2 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    0 white prepupae new    0 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    4 pupae 3d postWPP    1 pupae 4d postWPP    9 adult male 01day  26 adult male 05day  (87) adult male 30day    3 adult female 01day  (8190) adult female 05day  (14040) adult female 30day  (13835) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    2 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    0 white prepupae new    0 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    4 pupae 3d postWPP    1 pupae 4d postWPP    9 adult male 01day    26 adult male 05day    87 adult male 30day    3 adult female 01day  (8190) adult female 05day  (14040) adult female 30day  (13835) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    2 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    0 white prepupae new    0 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    4 pupae 3d postWPP    1 pupae 4d postWPP    9 adult male 01day    26 adult male 05day    87 adult male 30day    3 adult female 01day    8190 adult female 05day    14040 adult female 30day    13835 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    48 ovary OSC    7 ovary OSS    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS  (48) ovary OSC    7 ovary OSS  (27) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    48 ovary OSC    7 ovary OSS    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    48 ovary OSC    7 ovary OSS    27 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    48 ovary OSC    7 ovary OSS    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS  (48) ovary OSC    7 ovary OSS  27 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    48 ovary OSC    7 ovary OSS    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    48 ovary OSC    7 ovary OSS    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    22057 cold shock, 4-day adult    28901 heat shock, 4-day adult    8255 Cadmium 50 mM 6 hrs, larvae L3    95 Cadmium 50 mM 12 hrs, larvae L3    15 Cadmium 50 mM 48 hrs, 4-day adult    559 Cadmium 100 mM 48 hrs, 4-day adult    1424 Copper 0.5 mM 12 hrs, larvae L3    379 Copper 15 mM 48 hrs, 4-day adult    4597 Zinc 5 mM 12 hrs, larvae L3    2523 Zinc 4.5 mM 48 hrs, 4-day adult    9681 Ethanol 2.5% 3 hrs, larvae L3    7019 Ethanol 5% 3 hrs, larvae L3    16 Ethanol 10% 3 hrs, larvae L3    158 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    6713 Caffeine 25 mg/ml 48 hrs, 4-day adult    26008 Paraquat 5 mM 48 hrs, 4-day adult    6757 Paraquat 10 mM 48 hrs, 4-day adult    2953 Rotenone 2 μg 12 hrs, larvae L3    37 Rotenone 8 μg 12 hrs, larvae L3    31 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (22057) cold shock, 4-day adult  (28901) heat shock, 4-day adult  (8255) Cadmium 50 mM 6 hrs, larvae L3  (95) Cadmium 50 mM 12 hrs, larvae L3    15 Cadmium 50 mM 48 hrs, 4-day adult  (559) Cadmium 100 mM 48 hrs, 4-day adult  (1424) Copper 0.5 mM 12 hrs, larvae L3  (379) Copper 15 mM 48 hrs, 4-day adult  (4597) Zinc 5 mM 12 hrs, larvae L3  (2523) Zinc 4.5 mM 48 hrs, 4-day adult  (9681) Ethanol 2.5% 3 hrs, larvae L3  (7019) Ethanol 5% 3 hrs, larvae L3    16 Ethanol 10% 3 hrs, larvae L3  (158) Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (6713) Caffeine 25 mg/ml 48 hrs, 4-day adult  (26008) Paraquat 5 mM 48 hrs, 4-day adult  (6757) Paraquat 10 mM 48 hrs, 4-day adult  (2953) Rotenone 2 μg 12 hrs, larvae L3  (37) Rotenone 8 μg 12 hrs, larvae L3  (31) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult  (22057) cold shock, 4-day adult  (28901) heat shock, 4-day adult  (8255) Cadmium 50 mM 6 hrs, larvae L3    95 Cadmium 50 mM 12 hrs, larvae L3    15 Cadmium 50 mM 48 hrs, 4-day adult  (559) Cadmium 100 mM 48 hrs, 4-day adult  (1424) Copper 0.5 mM 12 hrs, larvae L3  (379) Copper 15 mM 48 hrs, 4-day adult  (4597) Zinc 5 mM 12 hrs, larvae L3  (2523) Zinc 4.5 mM 48 hrs, 4-day adult  (9681) Ethanol 2.5% 3 hrs, larvae L3  (7019) Ethanol 5% 3 hrs, larvae L3    16 Ethanol 10% 3 hrs, larvae L3  (158) Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (6713) Caffeine 25 mg/ml 48 hrs, 4-day adult  (26008) Paraquat 5 mM 48 hrs, 4-day adult  (6757) Paraquat 10 mM 48 hrs, 4-day adult  (2953) Rotenone 2 μg 12 hrs, larvae L3    37 Rotenone 8 μg 12 hrs, larvae L3    31 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    22057 cold shock, 4-day adult    28901 heat shock, 4-day adult    8255 Cadmium 50 mM 6 hrs, larvae L3    95 Cadmium 50 mM 12 hrs, larvae L3    15 Cadmium 50 mM 48 hrs, 4-day adult    559 Cadmium 100 mM 48 hrs, 4-day adult    1424 Copper 0.5 mM 12 hrs, larvae L3    379 Copper 15 mM 48 hrs, 4-day adult    4597 Zinc 5 mM 12 hrs, larvae L3    2523 Zinc 4.5 mM 48 hrs, 4-day adult    9681 Ethanol 2.5% 3 hrs, larvae L3    7019 Ethanol 5% 3 hrs, larvae L3    16 Ethanol 10% 3 hrs, larvae L3    158 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    6713 Caffeine 25 mg/ml 48 hrs, 4-day adult    26008 Paraquat 5 mM 48 hrs, 4-day adult    6757 Paraquat 10 mM 48 hrs, 4-day adult    2953 Rotenone 2 μg 12 hrs, larvae L3    37 Rotenone 8 μg 12 hrs, larvae L3    31 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    22057 cold shock, 4-day adult    28901 heat shock, 4-day adult    8255 Cadmium 50 mM 6 hrs, larvae L3    95 Cadmium 50 mM 12 hrs, larvae L3    15 Cadmium 50 mM 48 hrs, 4-day adult    559 Cadmium 100 mM 48 hrs, 4-day adult    1424 Copper 0.5 mM 12 hrs, larvae L3    379 Copper 15 mM 48 hrs, 4-day adult    4597 Zinc 5 mM 12 hrs, larvae L3    2523 Zinc 4.5 mM 48 hrs, 4-day adult    9681 Ethanol 2.5% 3 hrs, larvae L3    7019 Ethanol 5% 3 hrs, larvae L3    16 Ethanol 10% 3 hrs, larvae L3    158 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    6713 Caffeine 25 mg/ml 48 hrs, 4-day adult    26008 Paraquat 5 mM 48 hrs, 4-day adult    6757 Paraquat 10 mM 48 hrs, 4-day adult    2953 Rotenone 2 μg 12 hrs, larvae L3    37 Rotenone 8 μg 12 hrs, larvae L3    31 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (22057) cold shock, 4-day adult  (28901) heat shock, 4-day adult  (8255) Cadmium 50 mM 6 hrs, larvae L3  (95) Cadmium 50 mM 12 hrs, larvae L3    15 Cadmium 50 mM 48 hrs, 4-day adult  (559) Cadmium 100 mM 48 hrs, 4-day adult  (1424) Copper 0.5 mM 12 hrs, larvae L3  (379) Copper 15 mM 48 hrs, 4-day adult  (4597) Zinc 5 mM 12 hrs, larvae L3  (2523) Zinc 4.5 mM 48 hrs, 4-day adult  (9681) Ethanol 2.5% 3 hrs, larvae L3  (7019) Ethanol 5% 3 hrs, larvae L3    16 Ethanol 10% 3 hrs, larvae L3  (158) Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (6713) Caffeine 25 mg/ml 48 hrs, 4-day adult  (26008) Paraquat 5 mM 48 hrs, 4-day adult  (6757) Paraquat 10 mM 48 hrs, 4-day adult  (2953) Rotenone 2 μg 12 hrs, larvae L3  (37) Rotenone 8 μg 12 hrs, larvae L3  31 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult  (22057) cold shock, 4-day adult  (28901) heat shock, 4-day adult  (8255) Cadmium 50 mM 6 hrs, larvae L3    95 Cadmium 50 mM 12 hrs, larvae L3    15 Cadmium 50 mM 48 hrs, 4-day adult  (559) Cadmium 100 mM 48 hrs, 4-day adult  (1424) Copper 0.5 mM 12 hrs, larvae L3  (379) Copper 15 mM 48 hrs, 4-day adult  (4597) Zinc 5 mM 12 hrs, larvae L3  (2523) Zinc 4.5 mM 48 hrs, 4-day adult  (9681) Ethanol 2.5% 3 hrs, larvae L3  (7019) Ethanol 5% 3 hrs, larvae L3    16 Ethanol 10% 3 hrs, larvae L3  (158) Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (6713) Caffeine 25 mg/ml 48 hrs, 4-day adult  (26008) Paraquat 5 mM 48 hrs, 4-day adult  (6757) Paraquat 10 mM 48 hrs, 4-day adult  (2953) Rotenone 2 μg 12 hrs, larvae L3    37 Rotenone 8 μg 12 hrs, larvae L3    31 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    22057 cold shock, 4-day adult    28901 heat shock, 4-day adult    8255 Cadmium 50 mM 6 hrs, larvae L3    95 Cadmium 50 mM 12 hrs, larvae L3    15 Cadmium 50 mM 48 hrs, 4-day adult    559 Cadmium 100 mM 48 hrs, 4-day adult    1424 Copper 0.5 mM 12 hrs, larvae L3    379 Copper 15 mM 48 hrs, 4-day adult    4597 Zinc 5 mM 12 hrs, larvae L3    2523 Zinc 4.5 mM 48 hrs, 4-day adult    9681 Ethanol 2.5% 3 hrs, larvae L3    7019 Ethanol 5% 3 hrs, larvae L3    16 Ethanol 10% 3 hrs, larvae L3    158 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    6713 Caffeine 25 mg/ml 48 hrs, 4-day adult    26008 Paraquat 5 mM 48 hrs, 4-day adult    6757 Paraquat 10 mM 48 hrs, 4-day adult    2953 Rotenone 2 μg 12 hrs, larvae L3    37 Rotenone 8 μg 12 hrs, larvae L3    31 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_00
External Data & Images
Linkouts	BDGP expression data • RH64745 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004045 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2985-RA;CG9263-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Yp1 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 Yp1GD5003 Sterility Allele female sterile Yp1ts1 female sterile | dominant | heat sensitive Yp1ts1 female sterile | recessive Yp1ts1 female sterile soma-dependent | dominant | heat sensitive Yp1ts1 Other Phenotypes Allele body color defective, with Scer\GAL4pnr-MD237 Yp1GD5003 electrophoretic variant Yp1F Yp1S Phenotype manifest in Allele adult fat body Yp1ts1.RS2 adult fat body | heat sensitive Yp1ts1 egg | heat sensitive Yp1ts1 mesothoracic tergum, with Scer\GAL4pnr-MD237 Yp1GD5003
Classical Alleles ( 4 )
For All Classical Alleles Show
Allele of Yp1 Class Mutagen Stocks Known lesion Yp1ts1 1 Yes Yp1F natural population 0 -- Yp1OR 0 -- Yp1S natural population 0 --
Alleles Carried on Transgenic Constructs ( 30 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Yp1 Class Mutagen Stocks Known lesion Yp1GD5003 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Yp1KK106871 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Yp1+105.T:M13\M13 in vitro construct - deletion 0 Yes Yp1-159-340.T:M13\M13 in vitro construct - deletion 0 Yes Yp1-164+4.T:M13\M13 in vitro construct - deletion 0 Yes Yp1-2.T:M13\M13 in vitro construct - deletion 0 Yes Yp1-321.T:M13\M13 in vitro construct - deletion 0 Yes Yp1-883.T:M13\M13 in vitro construct - coding region fusion in vitro construct - deletion 0 Yes Yp1-89.T:M13\M13 in vitro construct - deletion 0 Yes Yp1Hsp70Bb.dmHSE-L1 in vitro construct 0 Yes Yp1Hsp70Bb.L1+23 in vitro construct - regulatory fusion 0 Yes Yp1Hsp70Bb.L1+30 in vitro construct - regulatory fusion 0 Yes Yp1Hsp70Bb.L1-12 in vitro construct - regulatory fusion 0 Yes Yp1Hsp70Bb.L1 in vitro construct - regulatory fusion 0 Yes Yp1Hsp70Bb.L2+23 in vitro construct - regulatory fusion 0 Yes Yp1Hsp70Bb.L2+30 in vitro construct - regulatory fusion 0 Yes Yp1Hsp70Bb.L2 in vitro construct - regulatory fusion 0 Yes Yp1Hsp70Bb.mmGAGA-L1 in vitro construct 0 Yes Yp1Hsp70Bb.UP1 in vitro construct - regulatory fusion 0 Yes Yp1Hsp70Bb.UP1x2 in vitro construct 0 Yes Yp1Hsp70Bb.UP1x5 in vitro construct 0 Yes Yp1Hsp70Bb.UP2 in vitro construct - regulatory fusion 0 Yes Yp1NA52 in vitro construct - deletion 0 Yes Yp1NA54 in vitro construct - deletion 0 Yes Yp1NA55 in vitro construct - deletion 0 Yes Yp1NA57 in vitro construct - deletion 0 Yes Yp1NIG.2985R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Yp1ts1.RS2 in vitro construct 0 Yes Yp1Yp2.T:M13\M13 in vitro construct - coding region fusion in vitro construct 0 Yes Yp1Yp2.Δ.T:M13\M13 in vitro construct - deletion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(1)BSC539 (Christensen et al., 2008.6.11) Df(1)BSC712 (Christensen et al., 2008.12.28) Df(1)BSC754 (Cook et al., 2009.2.28) Df(1)C52 (Postlethwait and Shirk, 1981, Minoo and Postlethwait, 1985, Bownes et al., 1991, Butterworth et al., 1992, Giorgi et al., 1993) Ts(1Lt;YSt)B52+Ts(1Rt;YSt)J2a (Minoo and Postlethwait, 1985)
Duplicated in	Dp(1;2)v+75d (Minoo and Postlethwait, 1985)
Not disrupted in	Df(1)v-L15 (Minoo and Postlethwait, 1985)
Transgenic Constructs & Insertions
Transgenic Constructs
reporter construct	Name Expression Data P{-5} No P{-10} No P{(-a-d-1b-)4} No P{(a-d-1b+)4} No P{(a-d+b-)4} No P{(a-d+b+)4} No P{(r,sub)4} No P{+5} No P{+10} No P{a-/o,r} No P{a-} No P{a-b-} No P{Adh.Yp1Δa} No P{Adh.Yp1Δb} No P{Adh.Yp1Δc} No P{Adh.Yp1Δd} No P{Adh.Yp1Δe} No P{Adh.Yp1Δf} No P{Adh.Yp1Δg} No P{Adh.Yp1Δh} No P{Adh.Yp1Δi} No P{Adh.Yp1Δj} No P{CR1} No P{CR1sub3} No P{CR2} No P{d-2a-} No P{l} No P{lacZYp1.subx} No P{lacZYp1.subxy} No P{lacZYp1.subxyz} No P{lacZYp1.subxz} No P{lacZYp1.suby} No P{lacZYp1.subyz} No P{lacZYp1.subz} No P{m} No P{ML-58} No P{neoyp1-Adh} No P{o} No P{o4S} No P{oe1/pX27} No P{r4} No P{sub1} No P{sub2} No P{sub3} No P{sub4} No P{sub5} No P{w3} No P{yp1,2,mini-w} No P{yp-1:MAR/SAR:hsp70:lacZ} No P{yp-1:scs-90BC:hsp70:lacZ} No P{Yp1-KS-lacZ} No P{Yp1-lacZ.FBE} No P{Yp1-lacZ.G1} No P{Yp1-lacZ.G2} No P{Yp1-lacZ.G3} No P{Yp1-lacZ.G4a} No P{Yp1-lacZ.G4b} No P{Yp1-lacZ.G5a} No P{Yp1-lacZ.G5b} No P{Yp1-lacZ.L1a} No P{Yp1-lacZ.L1b} No P{Yp1-lacZ.L2a} No P{Yp1-lacZ.L2b} No P{Yp1-lacZ.L3} No P{Yp1-lacZ.L4a} No P{Yp1-lacZ.L4b} No P{Yp1-lacZ.L5} No P{Yp1-lacZ.L6} No P{Yp1-lacZ.o2} No P{Yp1-lacZ.o4} No P{Yp1-lacZ.T} No P{Yp1-lacZ.U} No P{Yp1-lacZ-a-d-1} No P{Yp1-lacZ-a-d-1b-} No P{Yp1-lacZ-a-d-2b-} No P{Yp1-lacZ-b} No P{Yp1-lacZ-o-r} No P{Yp1-lacZ-o-w3} No P{Yp1-scs'-lacZ} No P{Yp1-scs<lacZ} No P{Yp1-scs>lacZ} No P{Yp1-spr-lacZ} No P{ZAPH} No P{ZAPU} No P{ZARG} No P{ZARH} No P{ZARS} No P{ZARU} No P{ZAΔUE} No
heat-shock construct	Name Expression Data P{dmHSE-L1} NA P{L1-12} NA P{L1} NA P{L1+23} NA P{L1+30} NA P{L2} NA P{L2+23} NA P{L2+30} NA P{mmGAGA-L1} NA P{UP1} NA P{UP1x2} NA P{UP1x5} NA P{UP2} NA
UAS construct	Name Expression Data P{GD5003} NA P{KK106871} NA P{NIG.2985R} NA
GAL4 construct	Name Expression Data P{yp1-tTA} No
characterization construct	Name Expression Data P{neo;yp11163} NA P{pNA52} NA P{pNA54} NA P{pNA55} NA P{YP1,2;wAFP2:YP1-3'} NA P{YP1,2;wAFP2} NA P{YP1:srAFP} NA P{Yp1.M13.G1} NA P{Yp1.M13.G2} NA P{Yp1.M13.G3} NA P{Yp1.M13.G4} NA P{Yp1.M13.L1} NA P{Yp1.M13.L2} NA P{YP1AFP} NA P{Yp(1+2)M13} NA P{Yp(1+2)M13Δ1} NA P{Yp(1+2)M13Δ2} NA P{YPHsAFP} NA P{Δ} NA P{ΔYpf1bp} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 7 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function ( 0 terms)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
lipid particle inferred from direct assay (Cermelli et al., 2006) microtubule associated complex inferred from direct assay (Hughes et al., 2008)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
catalytic activity inferred from electronic annotation with InterPro:IPR000734 (FlyBase Curators et al., 2004-) structural molecule activity inferred from sequence or structural similarity with UniProtKB:P27878 (FlyBase, 1992-)
Biological Process
CV term Evidence References
lipid metabolic process inferred from electronic annotation with InterPro:IPR000734 (FlyBase Curators et al., 2004-) sex differentiation non-traceable author statement (Schutt and Nothiger, 2000) traceable author statement (Christiansen et al., 2002) vitellogenesis inferred from sequence or structural similarity with UniProtKB:P27878 (FlyBase, 1992-) non-traceable author statement (Swiss-Prot Project Members, 1986.7.21)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Yp1 - Adh experimental knowledge based (Guruharsha et al., 2011) Yp1 - Argk experimental knowledge based (Guruharsha et al., 2011) Yp1 - CG16826 experimental knowledge based (Guruharsha et al., 2011) Yp1 - CG16885 experimental knowledge based (Guruharsha et al., 2011) Yp1 - CG3033 experimental knowledge based (Guruharsha et al., 2011) Yp1 - CG31343 experimental knowledge based (Guruharsha et al., 2011) Yp1 - CG32473 experimental knowledge based (Guruharsha et al., 2011) Yp1 - CG34205 experimental knowledge based (Guruharsha et al., 2011) Yp1 - CG5500 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Yp1 - CG5506 experimental knowledge based (Guruharsha et al., 2011) Yp1 - CG5966 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Yp1 - CG7979 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Yp1 - Fer1HCH experimental knowledge based (Guruharsha et al., 2011) Yp1 - Fer2LCH experimental knowledge based (Guruharsha et al., 2011) Yp1 - Iap2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Yp1 - Lsp2 experimental knowledge based (Guruharsha et al., 2011) Yp1 - RabX1 experimental knowledge based (Guruharsha et al., 2011) Yp1 - Rfabg experimental knowledge based (Guruharsha et al., 2011) Yp1 - Scp1 experimental knowledge based (Guruharsha et al., 2011) Yp1 - Synd experimental knowledge based (Guruharsha et al., 2011) Yp1 - Tsf1 experimental knowledge based (Guruharsha et al., 2011) Yp1 - Yp2 experimental knowledge based (Guruharsha et al., 2011) Yp1 - Yp3 experimental knowledge based (Guruharsha et al., 2011) Yp1 - proPO-A1 experimental knowledge based (Guruharsha et al., 2011)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Yp1 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 58375 DroID - A comprehensive database of gene and protein interactions. • FBgn0004045 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31939
Orthologs
OrthoDB Orthologs (12) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6R50NN Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search No orthologs identified Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG6R50NN)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Yp1     Drosophila simulans   Dsim\GD16970 Y   Drosophila sechellia   Dsec\GM11404 Y   Drosophila erecta   Dere\GG18339 Y   Drosophila yakuba   Dyak\GE17827 Y   Drosophila ananassae   Dana\GF19155 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA15558 Y   Drosophila persimilis   Dper\GL16391 Y   Drosophila willistoni   Dwil\GK25831 Y   Drosophila virilis   Dvir\Yp1 Y   Drosophila mojavensis   Dmoj\GI16001 Y   Drosophila grimshawi   Dgri\Yp1 Y
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (None identified)
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD16970 Drosophila sechellia Dsec\GM11404 Drosophila erecta Dere\GG18339 Drosophila yakuba Dyak\GE17827 Drosophila ananassae Dana\GF19155 Drosophila pseudoobscura pseudoobscura Dpse\GA15558 Drosophila persimilis Dper\GL16391 Drosophila willistoni Dwil\GK25831 Drosophila virilis Dvir\Yp1 Drosophila mojavensis Dmoj\GI16001 Drosophila grimshawi Dgri\Yp1
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
Bloomington	4568 Yp1ts1 w1 cv1 v1/C(1)DX, y1 f1
VDRC	v106735 P{KK106871}VIE-260B v13343 w1118; P{GD5003}v13343
Genomic Clones ( 1 )
	BACR07L06 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 605 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	IP13679 RH64745
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH01376 GH01632 GH01906 GH02639 GH02882 GH03291 GH03458 GH03719 GH03730 GH04342 GH05157 GH06648 GH07486 GH07749 GH08138 GH08538 GH08575 GH08989 GH09503 GH09749 GH09914 GH10037 GH10180 GH10274 GH10383 GH12028 GH12031 GH12070 GH12149 GH12251 GH13484 GH15218 GH15844 GH16476 GH16521 GH17460 GH17744 GH18105 GH18431 GH18449 GH18473 GH18633 GH18680 GH18723 GH19542 GH19976 GH19995 GH20461 GH20905 GH21092 GH21131 GH21142 GH21164 GH21663 GH21780 GH21791 GH21814 GH21893 GH22066 GH22076 GH22110 GH22208 GH22358 GH22511 GH22701 GH23052 GH23067 GH23091 GH23323 GH23435 GH23627 GH23762 GH23908 GH24358 GH24537 GH24659 GH24762 GH25172 GH25187 GH25219 GH25364 GH25769 GH25819 GH26469 GH26648 GH27172 GH27417 GH27711 GH28051 GH28510 GH28711 GM07424 GM25316 GM28954 HL01714 HL01807 HL02862 HL03339 HL05516 HL05617 RH09825 RH11461 RH12077 RH13121 RH13530 RH14627 RH22023 RH22292 RH26019 RH26022 RH27357 RH28375 RH30012 RH36623 RH41721 RH41877 RH42620 RH43235 RH44488 RH51264 RH51357 RH52394 RH52565 RH52641 RH54178 RH54571 RH55439 RH55702 RH56311 RH56376 RH56411 RH57654 RH58804 RH59983 RH60830 RH61152 RH61893 RH62585 RH65940 RH66316 RH67945 RH72704
Other clones	601 635 12098 33071 47750 53340 56546 97169 159691 159896 162550 275226 CK01.53C.E10 CK01.53D.F12 CK01.54A.G12 Dmel_dig_000291_0651_0355 Dmel_dig_000425_0695_0396 Dmel_dig_000770_0664_0355 Dmel_dig_001233_0655_0293 Dmel_dig_004310_0582_2483 Dmel_dig_004461_0619_3651 Dmel_dig_004823_0698_1440 Dmel_dig_004894_0707_2896 Dmel_dig_005040_0608_3707 Dmel_dig_005242_0585_1964 Dmel_dig_005560_0717_0519 Dmel_dig_005872_0695_0309 Dmel_dig_005979_0685_2637 Dmel_dig_007059_0674_1468 Dmel_dig_007251_0701_3299 Dmel_dig_007261_0614_3624 Dmel_dig_007772_0663_1492 Dmel_dig_008237_0628_0392 Dmel_dig_008317_0686_0769 Dmel_dig_008490_0692_1427 Dmel_dig_008541_0712_2183 Dmel_dig_008730_0707_2615 Dmel_dig_009392_0672_0586 Dmel_dig_009873_0700_1679 Dmel_dig_010622_0644_0395 Dmel_dig_010716_0651_1475 Dmel_dig_010770_0624_2124 Dmel_dig_010793_0612_1862 Dmel_dig_010970_0703_2961 Dmel_dig_011142_0597_2333 Dmel_dig_011374_0711_2712 Dmel_dig_011592_0593_3584 Dmel_dig_011766_0649_1483 Dmel_dig_011932_0710_0523 Dmel_dig_012543_0698_0590 Dmel_dig_012555_0683_2352 Dmel_dig_012652_0653_1225 Dmel_dig_012761_0644_0407 Dmel_dig_012914_0686_2164 Dmel_dig_013109_0598_1085 Dmel_dig_013198_0675_1260 Dmel_dig_013290_0604_2045 Dmel_dig_013374_0603_1134 Dmel_dig_013728_0610_2397 Dmel_dig_014059_0686_1658 Dmel_dig_014249_0632_1380 Dmel_dig_014489_0654_0574 Dmel_dig_014865_0635_3488 Dmel_dig_015438_0591_2604 Dmel_dig_015819_0629_0793 Dmel_dig_015926_0636_0342 Dmel_dig_016485_0646_2425 Dmel_dig_016817_0641_1779 Dmel_dig_016842_0695_2346 Dmel_dig_016883_0668_2613 Dmel_dig_017056_0673_2681 Dmel_dig_017209_0607_3111 Dmel_dig_017249_0594_0936 Dmel_dig_017341_0605_0581 Dmel_dig_017375_0708_3464 Dmel_dig_017458_0611_1069 Dmel_dig_017502_0712_2484 Dmel_dig_017627_0659_1009 Dmel_dig_017687_0588_3165 Dmel_dig_017697_0710_2709 Dmel_dig_017714_0619_1124 Dmel_dig_017806_0582_2436 Dmel_dig_018013_0584_2830 Dmel_dig_018095_0602_3756 Dmel_dig_018426_0597_2267 Dmel_dig_018521_0617_1885 Dmel_dig_018585_0620_3517 Dmel_dig_018707_0681_3196 Dmel_dig_018854_0685_3508 Dmel_dig_018881_0677_0763 Dmel_dig_018960_0670_2043 Dmel_dig_019067_0643_0809 Dmel_dig_019466_0615_2018 Dmel_dig_019852_0699_2731 Dmel_dig_020233_0634_0611 Dmel_dig_020303_0603_1209 Dmel_dig_020307_0592_0819 Dmel_dig_020493_0673_1323 Dmel_dig_020496_0642_2496 Dmel_dig_020608_0665_1523 Dmel_dig_020937_0712_1141 Dmel_neb_002339_0396_3594 Dmel_neb_003333_0162_0827 Dmel_neb_004698_0882_3580 Dmel_neb_004735_0946_3523 Dmel_neb_004825_0701_0322 Dmel_neb_005294_0833_2849 Dmel_neb_007300_0384_3166 Dmel_neb_007539_0872_3544 Dmel_neb_007619_0681_0598 Dmel_neb_007986_0167_1592 Dmel_neb_008462_0399_0959 Dmel_neb_008574_0143_2764 Dmel_neb_008753_0167_3255 Dmel_neb_008893_0163_2829 Dmel_neb_008905_0949_1174 Dmel_neb_009159_0938_3474 Dmel_neb_009187_0838_0368 Dmel_neb_009414_0661_2383 Dmel_neb_009479_0442_2518 Dmel_neb_009662_0316_3177 Dmel_neb_009681_0322_1599 Dmel_neb_009731_0636_1441 Dmel_neb_010248_0843_0437 Dmel_neb_010895_0397_0730 Dmel_neb_011174_0875_1295 Dmel_neb_011213_0603_1990 Dmel_neb_011680_0567_3405 Dmel_neb_011784_0666_2030 Dmel_neb_012127_0138_3056 Dmel_neb_012227_0901_1374 Dmel_neb_012483_0578_2089 Dmel_neb_012489_0084_2236 Dmel_neb_012500_0938_2352 Dmel_neb_012566_0639_2340 Dmel_neb_013006_0195_1358 Dmel_neb_013072_0573_1078 Dmel_neb_013133_0570_1809 Dmel_neb_013161_0698_1640 Dmel_neb_013205_0623_2728 Dmel_neb_013315_0341_2321 Dmel_neb_013323_0840_1054 Dmel_neb_013450_0331_2373 Dmel_neb_013578_0863_0842 Dmel_neb_013586_0416_0972 Dmel_neb_013686_0876_3147 Dmel_neb_013701_0860_0717 Dmel_neb_013722_0851_1543 Dmel_neb_013820_0693_1834 Dmel_neb_013971_0441_2636 Dmel_neb_014021_0110_2672 Dmel_neb_014063_0194_1118 Dmel_neb_014155_0628_0703 Dmel_neb_014230_0833_1649 Dmel_neb_014335_0376_3321 Dmel_neb_014356_0642_1547 Dmel_neb_014371_0153_0949 Dmel_neb_014381_0696_2012 Dmel_neb_014494_0702_0656 Dmel_neb_014738_0919_2937 Dmel_neb_014999_0329_1652 Dmel_neb_015083_0828_1878 Dmel_neb_015183_0909_2545 Dmel_neb_015201_0440_1210 Dmel_neb_015689_0692_2797 Dmel_neb_015884_0835_3516 Dmel_neb_015893_0630_3229 Dmel_neb_015967_0836_3414 Dmel_neb_015991_0580_1317 Dmel_neb_016030_0836_2578 EC054247 EK043349 EK043356 EK044558 EK112911 EK166104 EK169025 EK170810 EK174601 EK175712 EK230205 EK243204 EK250902 EK262650 GH01071 GH01102 GH01231 GH01325 GH01460 GH01503 GH01731 GH01835 GH02034 GH02134 GH02283 GH02509 GH02511 GH02978 GH03073 GH03084 GH03208 GH03358 GH03534 GH03775 GH03932 GH03985 GH04102 GH04218 GH04224 GH04310 GH04417 GH04612 GH05175 GH05388 GH05647 GH05653 GH05820 GH06030 GH06112 GH06325 GH06333 GH06432 GH06446 GH06688 GH06725 GH06812 GH06912 GH07045 GH07068 GH07220 GH07332 GH07441 GH07450 GH07704 GH07747 GH07840 GH07870 GH07882 GH07962 GH08219 GH08373 GH08450 GH08634 GH08721 GH08732 GH08802 GH08868 GH09050 GH09314 GH09456 GH10163 GH10555 GH10835 GH10866 GH11010 GH11056 GH11196 GH11414 GH11524 GH11555 GH11580 GH11610 GH11760 GH11866 GH11878 GH12193 GH12389 GH12457 GH12518 GH12776 GH12807 GH12848 GH12862 GH13109 GH13133 GH13322 GH13414 GH13513 GH13582 GH14124 GH14274 GH14529 GH14620 GH14850 GH14892 GH15010 GH15284 GH15473 GH15475 GH15561 GH15568 GH15611 GH15776 GH15878 GH15882 GH15885 GH15969 GH16018 GH16025 GH16175 GH16254 GH16256 GH16268 GH16387 GH16430 GH16504 GH16541 GH16772 GH17556 GH17601 GH17617 GH17629 GH17649 GH17803 GH17949 GH17969 GH18214 GH18401 GH18545 GH18571 GH18674 GH18711 GH18755 GH18825 GH18835 GH18926 GH18950 GH19009 GH19112 GH19146 GH19257 GH19259 GH19305 GH19313 GH19366 GH19376 GH19424 GH19721 GH19773 GH19959 GH20007 GH20059 GH20094 GH20324 GH20361 GH20453 GH20540 GH20601 GH20706 GH20880 GH20925 GH21064 GH21311 GH21425 GH21693 GH21892 GH21932 GH22013 GH22178 GH22189 GH22242 GH22255 GH22291 GH22426 GH22514 GH22534 GH22614 GH23229 GH23557 GH23956 GH23985 GH24217 GH24242 GH24910 GH25283 GH25414 GH25539 GH25703 GH25823 GH26042 GH26175 GH26294 GH26739 GH26957 GH27215 GH27521 GH27553 GH27819 GH28033 GH28439 GH28744 GH28827 HL01003 HL01710 HL02666 HL03707 HL03829 HL04077 HL04227 HL04401 HL04489 HL04745 HL04747 HL04958 HL05403 HL05682 HL05951 HL08027 IP02626 IP05041 IP06028 IP06128 IP06228 IP06328 IP06920 IP07020 IP07120 IP08913 IP11672 IP11772 IP11872 IP11972 IP12929 IP13129 IP14107 IP15421 IP17627 IP17727 IP17827 IP17927 RC0-DA0001-120700-013-B12 RC0-DA0001-120700-017-A10 RC0-DA0001-130700-115-A06 RC0-DA0001-130700-118-F01 RC0-DL0001-140700-011-A07 RC0-DL0001-140700-112-B02 RC0-DL0001-140700-117-F02 RC0-DL0001-140700-119-B04 RC0-DL0001-140700-119-B10 RH04904 RH08976 RH09524 RH09568 RH21810 RH26156 RH26411 RH28764 RH32616 RH36117 RH36310 RH41860 RH52434 RH59223 RH59849 RH60553 RH65909 RH65976 RH67470 RH68393 RH70845 RH71996
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0004045 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31939
Antibody Information
Other Information
Discoverer
	Postlethwait, March 1980.
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	In a sample of 79 genes with multiple introns, 33 showed significant heterogeneity in G+C content among introns of the same gene and significant positive correspondence between the intron and the third codon position G+C content within genes. These results are consistent with selection adding against preferred codons at the start of genes. (Kliman and Eyre-Walker, 1998) 20-Hydroxyecdysone, but not juvenile hormone, regulation of yolk protein gene expression can be mapped to cis-acting DNA sequences. It is not clear whether regulation by 20-hydroxyecdysone is direct or indirect. Methoprene up-regulation is only observed when native yolk protein genes are assayed, suggesting that it may operate through influencing stability of the message. (Bownes et al., 1996) Proteins which specifically bind the Yp1/Yp2 ovarian enhancer 1 element have been identified. (Chung et al., 1996) The o-r enhancer has four protein binding sites, three are involved in tissue specific transcription and the fourth is also necessary for sex specificity. (An and Wensink, 1995) Site directed mutagenesis, protein binding and germline transformation experiments identify and characterise the activity of a simple mini-enhancer from the fat body enhancer (FBE region) consisting of a single binding site (dsxA) for the dsx protein and two others for other regulatory proteins (slbo and ref1). One copy of this enhancer is sufficient to direct the sex and fat body specificities of Yp1 transcription. (An and Wensink, 1995) srp is expressed in the ovaries of adult flies where it produces an ovary specific protein isoform. The srp protein binds to a 12bp ovarian follicle cell-specific regulatory element located between the divergently transcribed Yp1 and Yp2. The 12bp element activates both in vivo and in vitro transcription of Yp1 and Yp2. (Lossky and Wensink, 1995) Insertion of the gypsy\su(Hw)BR into the Yp1 Yp2 intergenic region does not alter temporal or tissue-specific expression of the Adh or Ecol\lacZ reporter genes but does repress the Yp1 Yp2 fat body enhancer elements. (Scott and Geyer, 1995) Analysis of transgenic lines containing altered Hsp70Bb promoters (fused to reporter gene Yp1), analysed for their ability to bind Hsf protein, indicates that at least three promoter sequences facilitate the binding of Hsf to chromatin, including binding sites for Trl, Tbp and RNA polymerase II. (Shopland et al., 1995) The yolk protein genes Yp1 and Yp2 are only expressed in the ovary and fat body of females if they are supplied with proteinaceous food. Several regulatory regions have been shown to independently confer nutritional regulation on the expression of Yp1 and Yp2. (Sondergaard et al., 1995) Deletion analysis of the Yp1 upstream sequences has demonstrated that additional sequences are functionally equivalent to the fat body enhancer (FBE) in Yp1 upstream region. (Abrahamsen et al., 1993) In vitro mutagenesis of dsx binding sites demonstrates that in males the dsx gene product acts to directly repress transcription of the yolk genes and in females the dsx gene product activates transcription by acting at the same sites in the fat body enhancer (FBE) driving expression of Ecol\lacZ. Through the male and female dsx proteins the sexual differentiation pathway is connected to a target gene by acting directly, but with opposite effects, on the gene. (Coschigano and Wensink, 1993) Whereas in wild type ovarian follicles the Golgi apparatus and yolk spheres are preferentially labelled by osmium zinc iodide, in mutant follicles the Golgi apparatus and nearby vesicles showed dramatically reduced staining. Pattern of osmium zinc iodide staining in the cortical cytoplasm varies in relation to the number of yolk protein structural genes. (Giorgi et al., 1993) CrebA protein binds to the fat body specific enhancers of Dmul\Adh1, Adh, Yp1 and Yp2 and may be an important component of tissue specific regulation. (Abel et al., 1992) Newly synthesised yolk proteins in normal and mutant strains share secretory vesicles with putative vitelline membrane proteins. Translocation of follicle cell yolk protein is not through the membrane along the interfollicular spaces, but directly through plasmalemma facing the oocyte. (Butterworth et al., 1992) Ecol\lacZ reporter constructs carrying base substitutions in the AAE identify a negative regulatory element in the AAE to which the adult enhancer factor 1 (AEF1) binds. The AEF1 binding site, D.mulleri Adh-1 AAE and Yp1 gene fat body enhancer are related to a sequence recognised by the mammalian transcription factor C/EBP and a liver specific regulatory element of the human Adh gene. DNase I footprinting experiments reveal that AEF1 and C/EBP compete for adjacent binding sites in the fat body enhancers, AEF1 can displace bound C/EBP from its sites. (Falb and Maniatis, 1992) AEF1 binds specifically to fat body enhancer of Adh and Yp1. (Falb and Maniatis, 1992) Using Yp1 reporter gene constructs distal and proximal regions of the Hsp70 promoter have been identified that are required for formation of paused RNA polymerase II, the polymerase is transcriptionally engaged but paused about 25 nucleotides from the start site of Hsp70. (Lee et al., 1992) Evolutionary conservation of specificity of yolk protein uptake by the oocyte is studied throughout Diptera. (Martinez and Bownes, 1992) Female flies with varying numbers of Yp1, Yp2 and Yp3 genes have been generated. Each yolk protein gene makes an equivalent contribution to the fecundity and fertility of the female, and they do not individually provide unique functions to the embryo. The number of eggs laid by a female depends on the number of genes encoding yolk proteins present in the genome, and the probability of an egg producing an adult depends on the number of yolk protein genes present in the mother. (Bownes et al., 1991) The male and female products of dsx when expressed in E.coli bind specifically to the fat body enhancer (FBE) of Yp1 and Yp2. This demonstrates a direct interaction between the sex determination hierarchy and a target gene. (Burtis et al., 1991) The role of the ovary and nutritional signals in the regulation of Yp1 expression in the fat body has been studied. (Bownes and Reid, 1990) Yp1 and Yp2 are transcribed in the same sub-populations of ovarian follicle cells. This expression is directed by two enhancers: ovarian enhancer 1, located in the 1226bp intergenic region, and ovarian enhancer 2 located within the first exon of Yp2. (Logan and Wensink, 1990) Two cis-acting regions influence the transcription of both Yp1 and Yp2 in the ovaries. One is located in the 1224bp intergenic region and determines the stage and cell type specificity of ovarian transcription. The other is in the first intron of Yp2 and acts across the Yp2 promoter region to stimulate Yp1 transcription in ovaries. (Logan et al., 1989) A sequence-specific DNA-binding protein (Irbp) that has a high affinity for a 31bp sequence in the Yp1 gene necessary for normal steady state levels of Yp1 RNA in vivo has been identified. (Mitsis and Wensink, 1989) Yolk proteins share a certain homologous domains with human low-density lipoproteins and human lipoprotein lipase. (Baker, 1988) Analysis of a Yp1-Adh promoter construct shows that separate regulatory sequences are required for female-specific Yp1 expression and ecdysone-inducible Yp1 expression in males. (Shirras and Bownes, 1987) A 125bp segment of DNA located 196bp upstream of the Yp1 cap site is sufficient to determine the sex-, stage- and fat body specific expression of the Yp1 gene. This region can confer specific expression patterns on a heterologous promoter, and acts in either orientation. (Garabedian et al., 1986) The sex-, time- and tissue-specific expression of the Yp1 and Yp2 genes, divergently transcribed and separated by 1225bp, indicates that there are two tissue-specifying elements acting on each gene. One is necessary for expression in fat body and the other for expression in the ovary. (Garabedian et al., 1985) Yp2 has been cloned and sequenced, and compared with Yp1. The intergenic region between Yp1 and Yp2 has also been sequenced. (Hung and Wensink, 1983) Yp1 has been cloned. (Hovemann and Galler, 1982) The exon-intron structure of Yp1 has been determined. (Hung et al., 1982) The three major yolk proteins (encoded by Yp1, Yp2 and Yp3) have been isolated from mature eggs and characterised. (Mintzas and Kambysellis, 1982) The levels of Yp1 protein in a variety of sex-transformation mutants (tra, dsx and tra2) have been studied. (Ota et al., 1981) Hormonal and genetic regulation of yolk formation has been reviewed. (Postlethwait and Shirk, 1981) Structural gene for the yolk protein YP1 found in recently-emerged female flies. Protein migrates at different rates in SDS-polyacrylamide gels when encoded by the electrophoretic variants Yp1F (fast) and Yp1S (slow), alleles that are female fertile and produce normal amounts of YP1. Yp1ts1, which maps near the Yp1 locus and is believed to be an allele, produces a slow-migrating translation product that is present in reduced amounts in the hemolymph and the ovaries (Bownes and Hodson, 1980); this mutant is female sterile.
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078548 RefSeq (Proteins) • NP_511103 DDBJ / EMBL / GenBank • AAF46548 AAL68367 AY075560 BI624969 CAA23502 CAA25709 V00248 X01524 Entrez Gene - A searchable database of RefSeq genes. • 31939 UniProtKB/Swiss-Prot • P02843
Other Crossreferences
	EPD - Eukarytoic Promoter Database, an annotated collection of POL II promoters • 07022 07023 InterPro domains - A database of protein families, domains, and functional sites • Lipase (IPR000734) Lipase, N-terminal (IPR013818) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • RH64745
Linkouts
	BioGRID - A database of protein and genetic interactions • 58375 DroID - A comprehensive database of gene and protein interactions. • FBgn0004045 DRSC - Results from RNAi screens. • FBgn0004045 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004045 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2985-RA;CG9263-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0004045 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31939 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31939 modMine - Data generated by the modENCODE project. • FBgn0004045 REDfly - A database of transcriptional regulatory elements. • FBgn0004045
Synonyms & Secondary IDs ( 22 )
Reported As
Symbol Synonym	CG2985 (Nakahara et al., 2005, Cermelli et al., 2006, Lim et al., 2011, Horne et al., 2009, Keleman et al., 2009.8.5, Hughes et al., 2008, Monzo et al., 2010) DmYP1 (Handler, 1997) fs(1)1163 (Wieschaus et al., 1981, Postlethwait and Shirk, 1981, ) fs(1)A1163   VG1 (Persson et al., 1991) VIT1Dm (Horne et al., 2009) YP (Hediger et al., 2004, Carlson and Harshman, 1999, Hutson and Bownes, 2003, Sanchez and Guerrero, 2001, Richard et al., 2001, Soller et al., 1999, Sappington and Raikhel, 1998, de Loof et al., 1990, Vanzo et al., 2007, Papassideri et al., 2007, Richard et al., 2005, Trougakos et al., 2001) yp (Kubli, 2003, Schutt and Nothiger, 2000) Yp1 (Baker and Russell, 2009, Kadener et al., 2006, Markaki et al., 2004, Luo et al., 2011, Christensen et al., 2008.6.11, Sury et al., 2010, Goldman and Arbeitman, 2007, Rees et al., 2011, Kallappagoudar et al., 2010, Christensen et al., 2008.12.28, Cook et al., 2009.2.28, Sun and Cline, 2009, Sharma and Singh, 2009, Tarone et al., 2005, Monzo et al., 2010, McIntyre et al., 2006, Wasbrough et al., 2010, Parisi et al., 2004, Fisher et al., 2008, Japanese National Institute of Genetics, 2012.5.21) yp1 (Terashima and Bownes, 2004, Wolfner, 2003, Rifkin et al., 2003, Arnosti, 2002, Fujii and Amrein, 2002, Deshpande et al., 1999, Yi and Zarkower, 1999, Geyer, 1997, Duncker et al., 1997, Shopland and Lis, 1996, Chung et al., 1996, Bownes et al., 1996, Rasmussen and Lis, 1995, Sondergaard et al., 1995, Bownes, 1994, Jacoby and Wensink, 1994, Giorgi et al., 1993, Lee et al., 1992, McKeown and Madigan, 1992, Bownes et al., 1991, Liddell and Bownes, 1991, Lossky and Wensink, 1991, Butterworth et al., 1990, Mitsis and Wensink, 1989, Shirras and Bownes, 1987, Garabedian et al., 1987, Garabedian et al., 1986, van der Linde et al., 2010, Bownes et al., 2002) yp-1 (Waterbury et al., 1999, Udvardy, 1999) YP1 (Chatterjee and Mukherjee, 1996, Mettling et al., 1988, Baeuerle et al., 1988, Bownes and Scott, 1987, Nothiger and Steinmann-Zwicky, 1987, Giorgi and Postlethwait, 1985, Snyder et al., 1982, Ota et al., 1981, Flatt et al., 2005, Allen and Spradling, 2008, Compagnon et al., 2009, Horne et al., 2009, Kpebe and Rabinow, 2008) YP-1 (Mintzas and Kambysellis, 1982) YP1 (Granadino et al., 1991) YPI (Hovemann, 1997.2.17, Hovemann and Galler, 1982)
Name Synonym	vitellogenin (Persson et al., 1991, Sommer et al., 2005, Lee et al., 2012) Yok protein 1 (Tarone et al., 2005) yolk protein (Vieira et al., 1997, Richard et al., 2005) yolk protein 1 (Radyuk et al., 2005, Cermelli et al., 2006, Chintapalli et al., 2012, Tadros et al., 2007, Bownes et al., 2002, McIntyre et al., 2006, Culwell et al., 2008) yolk-protein 1 (Zarkower, 2001) Yolk protein 1 (Goldman and Arbeitman, 2007, Lim et al., 2011, McGraw et al., 2008) yolk protein I (Hovemann, 1993.3.25)
Secondary FlyBase IDs
References ( 226 )
Generate a list of	All references relating to this gene ( 226 )
List References by type	Research paper  ( 156 ) Supplementary material  ( 6 ) Review  ( 27 ) Personal communication to FlyBase  ( 10 ) Abstract  ( 16 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 2 ) Stock list  ( 1 ) Protein sequence record  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 ) Book  ( 1 ) Letter  ( 1 )
Recent research papers ( 10 )
	Herren et al., 2013, MBio 4(2): Vertical transmission of a Drosophila endosymbiont via cooption of the yolk transport and internalization machinery. [FBrf0220978] Chintapalli et al., 2012, PLoS ONE 7(3): e32577 Functional correlates of positional and gender-specific renal asymmetry in Drosophila. [FBrf0218070] Jubeaux et al., 2012, Environ. Sci. Technol. 46(11): 6315--6323 Vitellogenin-like Proteins among Invertebrate Species Diversity: Potential of Proteomic Mass Spectrometry for Biomarker Development. [FBrf0218577] Krauchunas et al., 2012, Dev. Biol. 370(1): 125--134 Protein phosphorylation changes reveal new candidates in the regulation of egg activation and early embryogenesis in D. melanogaster. [FBrf0219342] Lee et al., 2012, Proteomics 12(11): 1875--1878 Proteome reference map of Drosophila melanogaster head. [FBrf0218727] Hens et al., 2011, Nat. Methods 8(12): 1065--1070 Automated protein-DNA interaction screening of Drosophila regulatory elements. [FBrf0216759] Lim et al., 2011, FEBS Lett. 585(19): 3079--3085 The endogenous siRNA pathway in Drosophila impacts stress resistance and lifespan by regulating metabolic homeostasis. [FBrf0216303] Luo et al., 2011, Development 138(13): 2761--2771 Direct targets of the D. melanogaster DSXF protein and the evolution of sexual development. [FBrf0213878] Rees et al., 2011, Mol. Cell. Proteomics 10(6): M110.002386 In Vivo Analysis of Proteomes and Interactomes Using Parallel Affinity Capture (iPAC) Coupled to Mass Spectrometry. [FBrf0213845] Yang et al., 2011, G3 (Bethesda) 1(6): 427--436 Partitioning transcript variation in Drosophila: abundance, isoforms, and alleles. [FBrf0217638] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...