• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • RNA-Seq Search
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • GBrowse 2 Beta
    • CytoSearch
    • Feature Mapper
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Current release
  • Archived releases
  • Map Conversion
  • FTP site:
  • Releases (FTP)
  • Genomes (FTP)
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Vectors & Constructs
  • Other links:
  • BDGP
  • DGRC
  • DIS by issue
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\yrt

General Information
Symbol	Dmel\yrt	Species	D. melanogaster
Name	yurt	Annotation symbol	CG9764
Feature type	protein_coding_gene	FlyBase ID	FBgn0004049
Gene Model Status	Current	Stock availability	8 publicly available
Also Known As	l(3)m112, m112
Genomic Location
Chromosome (arm)	3R	Recombination map	3-52
Cytogenetic map	87E11-87E11	Sequence location	3R:9,254,589..9,260,704 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene yurt is referred to in FlyBase by the symbol Dmel\yrt (CG9764, FBgn0004049). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: cytoskeletal protein binding. There is experimental evidence that it is involved in the biological process: dorsal closure; amnioserosa maintenance; establishment or maintenance of apical/basal cell polarity; germ-band shortening; eye photoreceptor cell development; head involution. 26 alleles are reported. The phenotypes of these alleles are annotated with: embryonic/first instar larval cuticle; dorsal ridge; embryonic head; macrochaeta; amnioserosa; eye photoreceptor cell stalk; adherens junction; ommatidium; rhabdomere of eye photoreceptor cell. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: Band 4.1 domain; Band 4.1 family; Ezrin/radixin/moesin like; FERM adjacent (FA); FERM central domain; FERM conserved site; FERM domain; FERM, C-terminal PH-like domain; FERM, N-terminal; FERM/acyl-CoA-binding protein, 3-helical bundle; Pleckstrin homology-like domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the pupal period, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1629248_at completely aligns to an exonic region common to each of the 4 FlyBase-annotated transcript isoforms of yrt. Gene sequence location is 3R:9254589..9260704.
User Contributed Data
	Beta version, feedback welcome
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	yrt: yurt Embryonic lethal mutation. Embryos show a dorsal posterior hole.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 87E11-87E11   Limits computationally determined from genome sequence between P{PZ}CtBP03463 and P{lacW}B52s2249&P{lacW}flflL4179
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location	3-52 (Tearle and Nusslein-Volhard, 1987)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\yrt for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	DGC clone appears problematic: incomplete CDS (LD11531)
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) yrt-RA FBtr0082793  NM_142034   4367   972 yrt-RB FBtr0114374  NM_001144572   4247   932 yrt-RC FBtr0114375  NM_001144573   3809   786 yrt-RD FBtr0114376  NM_001144574   4462   919
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein yrt-PA   FBpp0082261   105.2   972   8.25     NP_650291   AAF54951 yrt-PB   FBpp0112923   101.0   932   8.50     NP_001138044   ACL83502 yrt-PC   FBpp0112924   86.5   786   9.04     NP_001138045   ACL83503 yrt-PD   FBpp0112925   99.5   919   7.79     NP_001138046   ACL83504
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • FERM domain (IPR000299) Ezrin/radixin/moesin like (IPR000798) Pleckstrin homology-like domain (IPR011993) FERM/acyl-CoA-binding protein, 3-helical bundle (IPR014352) FERM adjacent (FA) (IPR014847) FERM, C-terminal PH-like domain (IPR018980) FERM, N-terminal (IPR018979) FERM conserved site (IPR019747) FERM central domain (IPR019748) Band 4.1 domain (IPR019749) Band 4.1 family (IPR019750)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201557   AA390823   AA390904   AA392181   AA438889   AA735794   AA735800   AA816301   AA820325   AA820605   AA941024   AE014297 AAF54951   AC003923   AE014297 ACL83502   AE014297 ACL83503   AE014297 ACL83504   AI455472   AI455831   AI456090   AI457043   AI512015   AI517458   AI543831   AW942193   AY061133 AAL28681   BG638765   BI215254   BI228141   BI237175   BI237806   BI238728   BI243947   BI352548   BI356649   BI372121   BI373258   BI638924   BT015265 AAT94494   BX006495   BX007026   BX026032   BX029574   BX030199   BX056210   BZ748831   CO154441   CO184047   CO185777   CO195980   CO264379   CO284081   CO288001   CO293921   CO299698   CO308027   CO309603   CO311056   CO317750   CO318644   CZ478855   EC073633   EC074490   EC077620   EC080010   EC086810   EC201452   EC207563   EC211080   EC213276   EC213516   EC238427   EC255691   EC256475   EC267397   EF078694 ABK63800   EF078695 ABK63801   EV584601   EV596945   EV599363   EV600665   GH941366   GH948629   GH948823   GH952090   GH956381   GH960054   GH960590   GH960703   GH962250   GH966201   GH971451   GH971776   GH974159   GH975596   GH977571   GH979922   GH980867   GH980911   GH983545   GH984583
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VFU8 A0T1Z5 A0T1Z4 B7Z0J2 Q95RU5
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
basolateral plasma membrane inferred from direct assay (Laprise et al., 2006) septate junction inferred from direct assay (Laprise et al., 2006) zonula adherens inferred from direct assay (Laprise et al., 2006)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    238.25 Larval Midgut    195.5 Larval Hindgut    282 Larval Malpighian Tubules    143.9 Larval Fat Body    59.3 Larval Salivary Gland    154.4 Larval Trachea    222.4 Larval Carcass    194.65 Adult Head    154.7 Adult Eye    213.95 Adult Brain    187.3 Adult Thoracic-Abdominal Ganglion    126.2 Adult Crop    211.2 Adult Midgut    168.5 Adult Hindgut    182.6 Adult Malpighian Tubules    135.4 Adult Fat Body    42 Adult Salivary Gland    171 Adult Heart    92.5 Adult VirginFemale Spermatheca    128.7 Adult InseminatedFemale Spermatheca    133.9 Adult Ovary    303.7 Adult Testis    50.1 Adult Male Accessory Gland    140.5 Adult Carcass    78.3 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    238.25 Larval Midgut    195.5 Larval Hindgut    282 Larval Malpighian Tubules    143.9 Larval Fat Body    59.3 Larval Salivary Gland    154.4 Larval Trachea    222.4 Larval Carcass    194.65 Adult Head    154.7 Adult Eye    213.95 Adult Brain    187.3 Adult Thoracic-Abdominal Ganglion    126.2 Adult Crop    211.2 Adult Midgut    168.5 Adult Hindgut    182.6 Adult Malpighian Tubules    135.4 Adult Fat Body    42 Adult Salivary Gland    171 Adult Heart    92.5 Adult VirginFemale Spermatheca    128.7 Adult InseminatedFemale Spermatheca    133.9 Adult Ovary    303.7 Adult Testis    50.1 Adult Male Accessory Gland    140.5 Adult Carcass    78.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    238.25 Larval Midgut    195.5 Larval Hindgut    282 Larval Malpighian Tubules    143.9 Larval Fat Body    59.3 Larval Salivary Gland    154.4 Larval Trachea    222.4 Larval Carcass    194.65 Adult Head    154.7 Adult Eye    213.95 Adult Brain    187.3 Adult Thoracic-Abdominal Ganglion    126.2 Adult Crop    211.2 Adult Midgut    168.5 Adult Hindgut    182.6 Adult Malpighian Tubules    135.4 Adult Fat Body    42 Adult Salivary Gland    171 Adult Heart    92.5 Adult VirginFemale Spermatheca    128.7 Adult InseminatedFemale Spermatheca    133.9 Adult Ovary    303.7 Adult Testis    50.1 Adult Male Accessory Gland    140.5 Adult Carcass    78.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    238.25 Larval Midgut    195.5 Larval Hindgut    282 Larval Malpighian Tubules    143.9 Larval Fat Body    59.3 Larval Salivary Gland    154.4 Larval Trachea    222.4 Larval Carcass    194.65 Adult Head    154.7 Adult Eye    213.95 Adult Brain    187.3 Adult Thoracic-Abdominal Ganglion    126.2 Adult Crop    211.2 Adult Midgut    168.5 Adult Hindgut    182.6 Adult Malpighian Tubules    135.4 Adult Fat Body    42 Adult Salivary Gland    171 Adult Heart    92.5 Adult VirginFemale Spermatheca    128.7 Adult InseminatedFemale Spermatheca    133.9 Adult Ovary    303.7 Adult Testis    50.1 Adult Male Accessory Gland    140.5 Adult Carcass    78.3 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    238.25 Larval Midgut    195.5 Larval Hindgut    282 Larval Malpighian Tubules    143.9 Larval Fat Body    59.3 Larval Salivary Gland    154.4 Larval Trachea    222.4 Larval Carcass    194.65 Adult Head    154.7 Adult Eye    213.95 Adult Brain    187.3 Adult Thoracic-Abdominal Ganglion    126.2 Adult Crop    211.2 Adult Midgut    168.5 Adult Hindgut    182.6 Adult Malpighian Tubules    135.4 Adult Fat Body    42 Adult Salivary Gland    171 Adult Heart    92.5 Adult VirginFemale Spermatheca    128.7 Adult InseminatedFemale Spermatheca    133.9 Adult Ovary    303.7 Adult Testis    50.1 Adult Male Accessory Gland    140.5 Adult Carcass    78.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    238.25 Larval Midgut    195.5 Larval Hindgut    282 Larval Malpighian Tubules    143.9 Larval Fat Body    59.3 Larval Salivary Gland    154.4 Larval Trachea    222.4 Larval Carcass    194.65 Adult Head    154.7 Adult Eye    213.95 Adult Brain    187.3 Adult Thoracic-Abdominal Ganglion    126.2 Adult Crop    211.2 Adult Midgut    168.5 Adult Hindgut    182.6 Adult Malpighian Tubules    135.4 Adult Fat Body    42 Adult Salivary Gland    171 Adult Heart    92.5 Adult VirginFemale Spermatheca    128.7 Adult InseminatedFemale Spermatheca    133.9 Adult Ovary    303.7 Adult Testis    50.1 Adult Male Accessory Gland    140.5 Adult Carcass    78.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    238.25 Larval Midgut    195.5 Larval Hindgut    282 Larval Malpighian Tubules    143.9 Larval Fat Body    59.3 Larval Salivary Gland    154.4 Larval Trachea    222.4 Larval Carcass    194.65 Adult Head    154.7 Adult Eye    213.95 Adult Brain    187.3 Adult Thoracic-Abdominal Ganglion    126.2 Adult Crop    211.2 Adult Midgut    168.5 Adult Hindgut    182.6 Adult Malpighian Tubules    135.4 Adult Fat Body    42 Adult Salivary Gland    171 Adult Heart    92.5 Adult VirginFemale Spermatheca    128.7 Adult InseminatedFemale Spermatheca    133.9 Adult Ovary    303.7 Adult Testis    50.1 Adult Male Accessory Gland    140.5 Adult Carcass    78.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    238.25 Larval Midgut    195.5 Larval Hindgut    282 Larval Malpighian Tubules    143.9 Larval Fat Body    59.3 Larval Salivary Gland    154.4 Larval Trachea    222.4 Larval Carcass    194.65 Adult Head    154.7 Adult Eye    213.95 Adult Brain    187.3 Adult Thoracic-Abdominal Ganglion    126.2 Adult Crop    211.2 Adult Midgut    168.5 Adult Hindgut    182.6 Adult Malpighian Tubules    135.4 Adult Fat Body    42 Adult Salivary Gland    171 Adult Heart    92.5 Adult VirginFemale Spermatheca    128.7 Adult InseminatedFemale Spermatheca    133.9 Adult Ovary    303.7 Adult Testis    50.1 Adult Male Accessory Gland    140.5 Adult Carcass    78.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    154.7   NA  Eye    213.95   NA  Brain    187.3   238.25  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    126.2   NA  Crop    211.2   195.5  Midgut    168.5   282  Hindgut    182.6   143.9  Malpighian Tubules    135.4   59.3  Fat Body    42   154.4  Salivary Gland    171   NA  Heart    92.5   222.4  Trachea    NA   NA  VirginFemale Spermatheca    128.7   NA  InseminatedFemale Spermatheca    133.9   NA  Ovary    303.7   NA  Testis    50.1   NA  Male Accessory Gland    140.5   194.65  Carcass    78.3 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    38 central nervous system, larvae L3    21 central nervous system, pupae P8    17 head, virgin 1-day female    13 head, virgin 4-day female    12 head, virgin 20-day female    10 head, mated 1-day female    14 head, mated 4-day female    10 head, mated 20-day female    9 head, mated 1-day male    18 head, mated 4-day male    19 head, mated 20-day male    21 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    18 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    10 digestive system, 4-day adult    13 digestive system, 20-day adult    13 fat body, larvae L3 wandering    3 fat body, white prepupae    9 fat body, pupae P8    21 carcass, larvae L3 wandering    24 carcass, 1-day adult    8 carcass, 4-day adult    10 carcass, 20-day adult    9 ovary, virgin 4-day female    67 ovary, mated 4-day female    66 testis, mated 4-day male    13 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (38) central nervous system, larvae L3    21 central nervous system, pupae P8    17 head, virgin 1-day female    13 head, virgin 4-day female    12 head, virgin 20-day female    10 head, mated 1-day female    14 head, mated 4-day female    10 head, mated 20-day female    9 head, mated 1-day male    18 head, mated 4-day male    19 head, mated 20-day male    21 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    18 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    10 digestive system, 4-day adult    13 digestive system, 20-day adult    13 fat body, larvae L3 wandering    3 fat body, white prepupae    9 fat body, pupae P8    21 carcass, larvae L3 wandering    24 carcass, 1-day adult    8 carcass, 4-day adult    10 carcass, 20-day adult    9 ovary, virgin 4-day female  (67) ovary, mated 4-day female  (66) testis, mated 4-day male    13 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    38 central nervous system, larvae L3    21 central nervous system, pupae P8    17 head, virgin 1-day female    13 head, virgin 4-day female    12 head, virgin 20-day female    10 head, mated 1-day female    14 head, mated 4-day female    10 head, mated 20-day female    9 head, mated 1-day male    18 head, mated 4-day male    19 head, mated 20-day male    21 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    18 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    10 digestive system, 4-day adult    13 digestive system, 20-day adult    13 fat body, larvae L3 wandering    3 fat body, white prepupae    9 fat body, pupae P8    21 carcass, larvae L3 wandering    24 carcass, 1-day adult    8 carcass, 4-day adult    10 carcass, 20-day adult    9 ovary, virgin 4-day female    67 ovary, mated 4-day female    66 testis, mated 4-day male    13 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    38 central nervous system, larvae L3    21 central nervous system, pupae P8    17 head, virgin 1-day female    13 head, virgin 4-day female    12 head, virgin 20-day female    10 head, mated 1-day female    14 head, mated 4-day female    10 head, mated 20-day female    9 head, mated 1-day male    18 head, mated 4-day male    19 head, mated 20-day male    21 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    18 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    10 digestive system, 4-day adult    13 digestive system, 20-day adult    13 fat body, larvae L3 wandering    3 fat body, white prepupae    9 fat body, pupae P8    21 carcass, larvae L3 wandering    24 carcass, 1-day adult    8 carcass, 4-day adult    10 carcass, 20-day adult    9 ovary, virgin 4-day female    67 ovary, mated 4-day female    66 testis, mated 4-day male    13 accessory gland, mated 4-day male    8 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    38 central nervous system, larvae L3    21 central nervous system, pupae P8    17 head, virgin 1-day female    13 head, virgin 4-day female    12 head, virgin 20-day female    10 head, mated 1-day female    14 head, mated 4-day female    10 head, mated 20-day female    9 head, mated 1-day male    18 head, mated 4-day male    19 head, mated 20-day male    21 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    18 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    10 digestive system, 4-day adult    13 digestive system, 20-day adult    13 fat body, larvae L3 wandering    3 fat body, white prepupae    9 fat body, pupae P8    21 carcass, larvae L3 wandering    24 carcass, 1-day adult    8 carcass, 4-day adult    10 carcass, 20-day adult    9 ovary, virgin 4-day female    67 ovary, mated 4-day female    66 testis, mated 4-day male    13 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (38) central nervous system, larvae L3    21 central nervous system, pupae P8    17 head, virgin 1-day female    13 head, virgin 4-day female    12 head, virgin 20-day female    10 head, mated 1-day female    14 head, mated 4-day female    10 head, mated 20-day female    9 head, mated 1-day male    18 head, mated 4-day male    19 head, mated 20-day male    21 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    18 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    10 digestive system, 4-day adult    13 digestive system, 20-day adult    13 fat body, larvae L3 wandering    3 fat body, white prepupae    9 fat body, pupae P8    21 carcass, larvae L3 wandering    24 carcass, 1-day adult    8 carcass, 4-day adult    10 carcass, 20-day adult    9 ovary, virgin 4-day female  (67) ovary, mated 4-day female  (66) testis, mated 4-day male    13 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    38 central nervous system, larvae L3    21 central nervous system, pupae P8    17 head, virgin 1-day female    13 head, virgin 4-day female    12 head, virgin 20-day female    10 head, mated 1-day female    14 head, mated 4-day female    10 head, mated 20-day female    9 head, mated 1-day male    18 head, mated 4-day male    19 head, mated 20-day male    21 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    18 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    10 digestive system, 4-day adult    13 digestive system, 20-day adult    13 fat body, larvae L3 wandering    3 fat body, white prepupae    9 fat body, pupae P8    21 carcass, larvae L3 wandering    24 carcass, 1-day adult    8 carcass, 4-day adult    10 carcass, 20-day adult    9 ovary, virgin 4-day female    67 ovary, mated 4-day female    66 testis, mated 4-day male    13 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    38 central nervous system, larvae L3    21 central nervous system, pupae P8    17 head, virgin 1-day female    13 head, virgin 4-day female    12 head, virgin 20-day female    10 head, mated 1-day female    14 head, mated 4-day female    10 head, mated 20-day female    9 head, mated 1-day male    18 head, mated 4-day male    19 head, mated 20-day male    21 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    18 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    10 digestive system, 4-day adult    13 digestive system, 20-day adult    13 fat body, larvae L3 wandering    3 fat body, white prepupae    9 fat body, pupae P8    21 carcass, larvae L3 wandering    24 carcass, 1-day adult    8 carcass, 4-day adult    10 carcass, 20-day adult    9 ovary, virgin 4-day female    67 ovary, mated 4-day female    66 testis, mated 4-day male    13 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the pupal period, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    42 embryo 02-04hr    48 embryo 04-06hr    42 embryo 06-08hr    36 embryo 08-10hr    36 embryo 10-12hr    22 embryo 12-14hr    25 embryo 14-16hr    20 embryo 16-18hr    17 embryo 18-20hr    13 embryo 20-22hr    17 embryo 22-24hr    19 larva L1    7 larva L2    6 larva L3 12hr old    5 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    14 white prepupae new    15 white prepupae 12hr    19 white prepupae 24hr    25 pupae 2d postWPP    19 pupae 3d postWPP    13 pupae 4d postWPP    8 adult male 01day    9 adult male 05day    10 adult male 30day    10 adult female 01day    15 adult female 05day    27 adult female 30day    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (42) embryo 02-04hr  (48) embryo 04-06hr  (42) embryo 06-08hr  (36) embryo 08-10hr  (36) embryo 10-12hr    22 embryo 12-14hr    25 embryo 14-16hr    20 embryo 16-18hr    17 embryo 18-20hr    13 embryo 20-22hr    17 embryo 22-24hr    19 larva L1    7 larva L2    6 larva L3 12hr old    5 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    14 white prepupae new    15 white prepupae 12hr    19 white prepupae 24hr    25 pupae 2d postWPP    19 pupae 3d postWPP    13 pupae 4d postWPP    8 adult male 01day    9 adult male 05day    10 adult male 30day    10 adult female 01day    15 adult female 05day  (27) adult female 30day  (27) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    42 embryo 02-04hr    48 embryo 04-06hr    42 embryo 06-08hr    36 embryo 08-10hr    36 embryo 10-12hr    22 embryo 12-14hr    25 embryo 14-16hr    20 embryo 16-18hr    17 embryo 18-20hr    13 embryo 20-22hr    17 embryo 22-24hr    19 larva L1    7 larva L2    6 larva L3 12hr old    5 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    14 white prepupae new    15 white prepupae 12hr    19 white prepupae 24hr    25 pupae 2d postWPP    19 pupae 3d postWPP    13 pupae 4d postWPP    8 adult male 01day    9 adult male 05day    10 adult male 30day    10 adult female 01day    15 adult female 05day    27 adult female 30day    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    42 embryo 02-04hr    48 embryo 04-06hr    42 embryo 06-08hr    36 embryo 08-10hr    36 embryo 10-12hr    22 embryo 12-14hr    25 embryo 14-16hr    20 embryo 16-18hr    17 embryo 18-20hr    13 embryo 20-22hr    17 embryo 22-24hr    19 larva L1    7 larva L2    6 larva L3 12hr old    5 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    14 white prepupae new    15 white prepupae 12hr    19 white prepupae 24hr    25 pupae 2d postWPP    19 pupae 3d postWPP    13 pupae 4d postWPP    8 adult male 01day    9 adult male 05day    10 adult male 30day    10 adult female 01day    15 adult female 05day    27 adult female 30day    27 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    42 embryo 02-04hr    48 embryo 04-06hr    42 embryo 06-08hr    36 embryo 08-10hr    36 embryo 10-12hr    22 embryo 12-14hr    25 embryo 14-16hr    20 embryo 16-18hr    17 embryo 18-20hr    13 embryo 20-22hr    17 embryo 22-24hr    19 larva L1    7 larva L2    6 larva L3 12hr old    5 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    14 white prepupae new    15 white prepupae 12hr    19 white prepupae 24hr    25 pupae 2d postWPP    19 pupae 3d postWPP    13 pupae 4d postWPP    8 adult male 01day    9 adult male 05day    10 adult male 30day    10 adult female 01day    15 adult female 05day    27 adult female 30day    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (42) embryo 02-04hr  (48) embryo 04-06hr  (42) embryo 06-08hr  (36) embryo 08-10hr  (36) embryo 10-12hr    22 embryo 12-14hr    25 embryo 14-16hr    20 embryo 16-18hr    17 embryo 18-20hr    13 embryo 20-22hr    17 embryo 22-24hr    19 larva L1    7 larva L2    6 larva L3 12hr old    5 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    14 white prepupae new    15 white prepupae 12hr    19 white prepupae 24hr    25 pupae 2d postWPP    19 pupae 3d postWPP    13 pupae 4d postWPP    8 adult male 01day    9 adult male 05day    10 adult male 30day    10 adult female 01day    15 adult female 05day  27 adult female 30day  27 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    42 embryo 02-04hr    48 embryo 04-06hr    42 embryo 06-08hr    36 embryo 08-10hr    36 embryo 10-12hr    22 embryo 12-14hr    25 embryo 14-16hr    20 embryo 16-18hr    17 embryo 18-20hr    13 embryo 20-22hr    17 embryo 22-24hr    19 larva L1    7 larva L2    6 larva L3 12hr old    5 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    14 white prepupae new    15 white prepupae 12hr    19 white prepupae 24hr    25 pupae 2d postWPP    19 pupae 3d postWPP    13 pupae 4d postWPP    8 adult male 01day    9 adult male 05day    10 adult male 30day    10 adult female 01day    15 adult female 05day    27 adult female 30day    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    42 embryo 02-04hr    48 embryo 04-06hr    42 embryo 06-08hr    36 embryo 08-10hr    36 embryo 10-12hr    22 embryo 12-14hr    25 embryo 14-16hr    20 embryo 16-18hr    17 embryo 18-20hr    13 embryo 20-22hr    17 embryo 22-24hr    19 larva L1    7 larva L2    6 larva L3 12hr old    5 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    14 white prepupae new    15 white prepupae 12hr    19 white prepupae 24hr    25 pupae 2d postWPP    19 pupae 3d postWPP    13 pupae 4d postWPP    8 adult male 01day    9 adult male 05day    10 adult male 30day    10 adult female 01day    15 adult female 05day    27 adult female 30day    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    20 Schneider line 2 Sg4    7 embryonic 1182-4H    19 embryonic GM2    16 embryonic Kc167    18 embryonic S1    20 embryonic S3    8 leg disc CME L1    9 wing disc CME-W2    11 wing disc ML-DmD8    13 wing disc ML-DmD9    17 wing disc ML-DmD16-c3    17 wing disc ML-DmD21    7 wing disc ML-DmD32    11 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    5 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    17 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    13 ovary fGS/OSS    31 ovary OSC    34 ovary OSS    21 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    20 Schneider line 2 Sg4    7 embryonic 1182-4H    19 embryonic GM2    16 embryonic Kc167    18 embryonic S1    20 embryonic S3    8 leg disc CME L1    9 wing disc CME-W2    11 wing disc ML-DmD8    13 wing disc ML-DmD9    17 wing disc ML-DmD16-c3    17 wing disc ML-DmD21    7 wing disc ML-DmD32    11 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    5 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    17 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    13 ovary fGS/OSS  (31) ovary OSC  (34) ovary OSS    21 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    20 Schneider line 2 Sg4    7 embryonic 1182-4H    19 embryonic GM2    16 embryonic Kc167    18 embryonic S1    20 embryonic S3    8 leg disc CME L1    9 wing disc CME-W2    11 wing disc ML-DmD8    13 wing disc ML-DmD9    17 wing disc ML-DmD16-c3    17 wing disc ML-DmD21    7 wing disc ML-DmD32    11 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    5 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    17 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    13 ovary fGS/OSS    31 ovary OSC    34 ovary OSS    21 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    20 Schneider line 2 Sg4    7 embryonic 1182-4H    19 embryonic GM2    16 embryonic Kc167    18 embryonic S1    20 embryonic S3    8 leg disc CME L1    9 wing disc CME-W2    11 wing disc ML-DmD8    13 wing disc ML-DmD9    17 wing disc ML-DmD16-c3    17 wing disc ML-DmD21    7 wing disc ML-DmD32    11 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    5 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    17 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    13 ovary fGS/OSS    31 ovary OSC    34 ovary OSS    21 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    20 Schneider line 2 Sg4    7 embryonic 1182-4H    19 embryonic GM2    16 embryonic Kc167    18 embryonic S1    20 embryonic S3    8 leg disc CME L1    9 wing disc CME-W2    11 wing disc ML-DmD8    13 wing disc ML-DmD9    17 wing disc ML-DmD16-c3    17 wing disc ML-DmD21    7 wing disc ML-DmD32    11 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    5 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    17 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    13 ovary fGS/OSS    31 ovary OSC    34 ovary OSS    21 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    20 Schneider line 2 Sg4    7 embryonic 1182-4H    19 embryonic GM2    16 embryonic Kc167    18 embryonic S1    20 embryonic S3    8 leg disc CME L1    9 wing disc CME-W2    11 wing disc ML-DmD8    13 wing disc ML-DmD9    17 wing disc ML-DmD16-c3    17 wing disc ML-DmD21    7 wing disc ML-DmD32    11 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    5 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    17 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    13 ovary fGS/OSS  31 ovary OSC  (34) ovary OSS    21 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    20 Schneider line 2 Sg4    7 embryonic 1182-4H    19 embryonic GM2    16 embryonic Kc167    18 embryonic S1    20 embryonic S3    8 leg disc CME L1    9 wing disc CME-W2    11 wing disc ML-DmD8    13 wing disc ML-DmD9    17 wing disc ML-DmD16-c3    17 wing disc ML-DmD21    7 wing disc ML-DmD32    11 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    5 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    17 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    13 ovary fGS/OSS    31 ovary OSC    34 ovary OSS    21 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    20 Schneider line 2 Sg4    7 embryonic 1182-4H    19 embryonic GM2    16 embryonic Kc167    18 embryonic S1    20 embryonic S3    8 leg disc CME L1    9 wing disc CME-W2    11 wing disc ML-DmD8    13 wing disc ML-DmD9    17 wing disc ML-DmD16-c3    17 wing disc ML-DmD21    7 wing disc ML-DmD32    11 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    5 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    17 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    13 ovary fGS/OSS    31 ovary OSC    34 ovary OSS    21 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    18 cold shock, 4-day adult    12 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    22 Cadmium 100 mM 48 hrs, 4-day adult    50 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    36 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    19 Ethanol 2.5% 3 hrs, larvae L3    42 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    46 Caffeine 25 mg/ml 48 hrs, 4-day adult    21 Paraquat 5 mM 48 hrs, 4-day adult    38 Paraquat 10 mM 48 hrs, 4-day adult    28 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    18 cold shock, 4-day adult    12 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    22 Cadmium 100 mM 48 hrs, 4-day adult  (50) Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult  (36) Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    19 Ethanol 2.5% 3 hrs, larvae L3  (42) Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (46) Caffeine 25 mg/ml 48 hrs, 4-day adult    21 Paraquat 5 mM 48 hrs, 4-day adult  (38) Paraquat 10 mM 48 hrs, 4-day adult  (28) Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    18 cold shock, 4-day adult    12 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    22 Cadmium 100 mM 48 hrs, 4-day adult    50 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    36 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    19 Ethanol 2.5% 3 hrs, larvae L3    42 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    46 Caffeine 25 mg/ml 48 hrs, 4-day adult    21 Paraquat 5 mM 48 hrs, 4-day adult    38 Paraquat 10 mM 48 hrs, 4-day adult    28 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    18 cold shock, 4-day adult    12 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    22 Cadmium 100 mM 48 hrs, 4-day adult    50 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    36 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    19 Ethanol 2.5% 3 hrs, larvae L3    42 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    46 Caffeine 25 mg/ml 48 hrs, 4-day adult    21 Paraquat 5 mM 48 hrs, 4-day adult    38 Paraquat 10 mM 48 hrs, 4-day adult    28 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    18 cold shock, 4-day adult    12 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    22 Cadmium 100 mM 48 hrs, 4-day adult    50 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    36 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    19 Ethanol 2.5% 3 hrs, larvae L3    42 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    46 Caffeine 25 mg/ml 48 hrs, 4-day adult    21 Paraquat 5 mM 48 hrs, 4-day adult    38 Paraquat 10 mM 48 hrs, 4-day adult    28 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    18 cold shock, 4-day adult    12 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    22 Cadmium 100 mM 48 hrs, 4-day adult  (50) Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult  (36) Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    19 Ethanol 2.5% 3 hrs, larvae L3  (42) Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (46) Caffeine 25 mg/ml 48 hrs, 4-day adult    21 Paraquat 5 mM 48 hrs, 4-day adult  (38) Paraquat 10 mM 48 hrs, 4-day adult  28 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    18 cold shock, 4-day adult    12 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    22 Cadmium 100 mM 48 hrs, 4-day adult    50 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    36 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    19 Ethanol 2.5% 3 hrs, larvae L3    42 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    46 Caffeine 25 mg/ml 48 hrs, 4-day adult    21 Paraquat 5 mM 48 hrs, 4-day adult    38 Paraquat 10 mM 48 hrs, 4-day adult    28 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    18 cold shock, 4-day adult    12 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    22 Cadmium 100 mM 48 hrs, 4-day adult    50 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    36 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    19 Ethanol 2.5% 3 hrs, larvae L3    42 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    46 Caffeine 25 mg/ml 48 hrs, 4-day adult    21 Paraquat 5 mM 48 hrs, 4-day adult    38 Paraquat 10 mM 48 hrs, 4-day adult    28 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_17 mE1_20_mRNA_expression_cluster_04
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004049 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9764-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal yrt87Ek-2 yrt87Ek-3 yrt87Ek-4 yrt87Ek-5 yrt87Ek-6 yrt87Ek-7 lethal | embryonic stage | recessive yrtunspecified viable, with Scer\GAL4pnr-MD237 yrtGD13224 Other Phenotypes Allele cell polarity defective | embryonic stage 13 | germline clone yrt75 Phenotype manifest in Allele adherens junction yrt75 amnioserosa yrt87Ek-8 dorsal ridge yrtunspecified embryo | dorsal | posterior yrtunspecified embryonic/first instar larval cuticle (with Df(3R)l26c) yrt87Ek-8 yrt87Ek-9 embryonic/first instar larval cuticle (with yrt87Ek-8) yrt87Ek-9 embryonic/first instar larval cuticle (with yrt87Ek-9) yrt87Ek-8 embryonic/first instar larval cuticle | germline clone yrt75 embryonic head (with Df(3R)l26c) yrt87Ek-8 yrt87Ek-9 embryonic head (with yrt87Ek-8) yrt87Ek-9 embryonic head (with yrt87Ek-9) yrt87Ek-8 epidermis | embryonic stage 13 | germline clone yrt75 eye photoreceptor cell | conditional yrt75 eye photoreceptor cell stalk yrt75 macrochaeta yrt87Ek-5 yrt87Ek-6 yrt87Ek-7 ommatidium yrt87Ek-5 yrt87Ek-6 yrt87Ek-7 rhabdomere of eye photoreceptor cell yrt75 trachea | embryonic stage 13 | germline clone yrt75
Classical Alleles ( 20 )
For All Classical Alleles Show
Allele of yrt Class Mutagen Stocks Known lesion yrt87Ek-7 ethyl methanesulfonate 1 -- yrte01024 piggyBac transposase 1 -- yrtEY01443 P-element activity 1 -- yrt1 ethyl methanesulfonate 0 -- yrt2 ethyl methanesulfonate 0 -- yrt3 ethyl methanesulfonate 0 -- yrt65 P-element activity 0 Yes yrt75 P-element activity 0 Yes yrt75a 0 -- yrt87Ek-10 ethyl methanesulfonate 0 -- yrt87Ek-11 ethyl methanesulfonate 0 -- yrt87Ek-1 0 -- yrt87Ek-2 ethyl methanesulfonate 0 -- yrt87Ek-3 ethyl methanesulfonate 0 -- yrt87Ek-4 ethyl methanesulfonate 0 -- yrt87Ek-5 gamma ray 0 -- yrt87Ek-6 gamma ray 0 -- yrt87Ek-8 ethyl methanesulfonate 0 Yes yrt87Ek-9 ethyl methanesulfonate 0 Yes yrtunspecified 0 --
Alleles Carried on Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Allele of yrt Class Mutagen Stocks Known lesion yrtGD13224 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes yrtHMS01532 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes yrtJF01600 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes yrtJF03429 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes yrtKK101638 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes yrtScer\UAS.cMa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)2515 (McCarron et al., 1994) Df(3R)2520 (McCarron et al., 1994) Df(3R)Exel7320 (Ryder, 2004.4.26) Df(3R)l26c (Hoover and Bryant, 2002, Hilliker et al., 1980, Hilliker et al., 1981, Rushlow and Chovnick, 1984, Jurgens et al., 1984, Tearle and Nusslein-Volhard, 1987, Manseau et al., 1988) Df(3R)ry506-85C (Harbecke and Lengyel, 1995) Df(3R)ry619 (Hilliker et al., 1980, Hilliker et al., 1981, Rushlow and Chovnick, 1984, Manseau et al., 1988)
Not disrupted in	Df(3R)615 (McCarron et al., 1994) Df(3R)2519 (McCarron et al., 1994) Df(3R)2521 (McCarron et al., 1994) Df(3R)2522 (McCarron et al., 1994) Df(3R)2523 (McCarron et al., 1994) Df(3R)2524 (McCarron et al., 1994) Df(3R)2525 (McCarron et al., 1994) Df(3R)2526 (McCarron et al., 1994) Df(3R)2527 (McCarron et al., 1994) Df(3R)2528 (McCarron et al., 1994) Df(3R)kar-H5 (McCarron et al., 1994) Df(3R)kar-lG27 (Hilliker et al., 1980, Hilliker et al., 1981, Rushlow and Chovnick, 1984) Df(3R)kar-Sz8 (Tearle and Nusslein-Volhard, 1987) Df(3R)kar-Sz11 (Hilliker et al., 1980, Hilliker et al., 1981, Rushlow and Chovnick, 1984) Df(3R)l26d (Hilliker et al., 1980, Hilliker et al., 1981, Rushlow and Chovnick, 1984) Df(3R)lC4a (Hilliker et al., 1980, Hilliker et al., 1981, Rushlow and Chovnick, 1984, Manseau et al., 1988) Df(3R)ry36 (Hilliker et al., 1980, Hilliker et al., 1981, Rushlow and Chovnick, 1984) Df(3R)ry75 (Hilliker et al., 1980, Hilliker et al., 1981, Rushlow and Chovnick, 1984) Df(3R)ry614 (Hilliker et al., 1980, Hilliker et al., 1981, Rushlow and Chovnick, 1984) Df(3R)ry1168 (Hilliker et al., 1980, Hilliker et al., 1981, Rushlow and Chovnick, 1984, Manseau et al., 1988) Df(3R)ry1301 (Hilliker et al., 1980, Hilliker et al., 1981, Rushlow and Chovnick, 1984) Df(3R)ry1402 (Hilliker et al., 1980, Hilliker et al., 1981, Rushlow and Chovnick, 1984) Df(3R)ry1607 (Hilliker et al., 1980, Hilliker et al., 1981, Rushlow and Chovnick, 1984) Df(3R)ry1608 (Hilliker et al., 1980, Hilliker et al., 1981, Rushlow and Chovnick, 1984)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD13224} NA P{KK101638} NA P{TRiP.HMS01532} NA P{TRiP.JF01600} NA P{TRiP.JF03429} NA P{UAS-yrt.M} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{RB}yrte01024 NA insertion of mobile activating element P{EPgy2}yrtEY01443 NA P{GSV1}EP-1152.1EP-1152.1 NA P{GSV1}EP-EEP-E NA
Gene Ontology: Function, Process & Cellular Component ( 13 unique terms )
Terms Based on Experimental Evidence ( 9 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
amnioserosa maintenance inferred from mutant phenotype (Hoover and Bryant, 2002) dorsal closure inferred from mutant phenotype (Hoover and Bryant, 2002) establishment or maintenance of apical/basal cell polarity inferred from mutant phenotype (Laprise et al., 2006) eye photoreceptor cell development inferred from mutant phenotype (Laprise et al., 2006) germ-band shortening inferred from mutant phenotype (Hoover and Bryant, 2002) head involution inferred from mutant phenotype (Hoover and Bryant, 2002)
Cellular Component
CV term Evidence References
basolateral plasma membrane inferred from direct assay (Laprise et al., 2006) septate junction inferred from direct assay (Laprise et al., 2006) zonula adherens inferred from direct assay (Laprise et al., 2006)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
cytoskeletal protein binding inferred from electronic annotation with InterPro:IPR000798 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
cytoplasm inferred from electronic annotation with InterPro:IPR000798 (FlyBase Curators et al., 2004-) cytoskeleton inferred from electronic annotation with InterPro:IPR000299 (FlyBase Curators et al., 2004-) extrinsic to membrane inferred from electronic annotation with InterPro:IPR000798 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
yrt - CG3744 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) yrt - Ocrl anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) yrt - Pitslre anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) yrt - l(2)35Bd anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) yrt - verm anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions yrt allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 66738 DroID - A comprehensive database of gene and protein interactions. • FBgn0004049 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41656
Orthologs
OrthoDB Orthologs (43) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6X3HMC Dipteran inclusive ortholog search EOG6B2T5H Insect inclusive ortholog search EOG6NP5ZK Arthropod inclusive ortholog search EOG6STQKR Metazoa inclusive ortholog search EOG6C00W5
Orthologs in Drosophila Species (EOG6X3HMC)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\yrt     Drosophila simulans   Dsim\GD20496 Y   Drosophila sechellia   Dsec\GM25934 Y   Drosophila erecta   Dere\GG17049 Y   Drosophila yakuba   Dyak\GE24437 Y   Drosophila ananassae   Dana\GF17379 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA22017 Y   Drosophila persimilis   Dper\GL23983 Y   Drosophila willistoni   Dwil\GK13341 Y   Drosophila virilis   Dvir\GJ10735 Y   Drosophila mojavensis   Dmoj\GI23239 Y   Drosophila grimshawi   Dgri\GH18540 Y
Orthologs in non-Drosophila Dipterans (EOG6B2T5H)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL004623   Anopheles gambiae Malaria mosquito  Agam\AGAP004136   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ005784
Orthologs in non-Dipteran Insects (EOG6NP5ZK)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB51029   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG011953   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH16943   Atta cephalotes Leafcutter ant  Acep\ACEP21366   Camponotus floridanus Florida carpenter ant  Cflo\CFLO17789   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL13633   Linepithema humile Argentine ant  Lhum\LH11094   Pogonomyrmex barbatus Red harvester ant  Pbar\PB20783   Solenopsis invicta Red fire ant  Sinv\SINV23261   Acyrthosiphon pisum Pea aphid  Apim\ACYPI068606   Pediculus humanus Human body louse  Phum\PHUM310370   Tribolium castaneum Red flour beetle  Tcas\GLEAN_15016
Orthologs in non-Insect Arthropods (EOG6STQKR)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\rpl14
Orthologs in non-Arthropod Metazoa (EOG6C00W5)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\frm-2   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_014957gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_014956gn   Danio rerio Zebrafish  Drer\epb41l4b   Danio rerio Zebrafish  Drer\epb41l5   Xenopus tropicalis Western clawed frog  Xtro\epb41l5   Gallus gallus Domestic chicken  Ggal\EPB41L4B   Gallus gallus Domestic chicken  Ggal\EPB41L5   Mus musculus House mouse  Mmus\ENSMUSG00000026383   Mus musculus House mouse  Mmus\Epb4.1l4b   Rattus norvegicus Norway rat  Rnor\Epb41l4b   Rattus norvegicus Norway rat  Rnor\Epb4.1l5   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000023374   Homo sapiens Human  Hsap\EPB41L5   Homo sapiens Human  Hsap\EPB41L4B
Human Orthologs (2)
Gene OMIM HGNC Hsap\EPB41L5     Hsap\EPB41L4B
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD20496 Drosophila sechellia Dsec\GM25934 Drosophila erecta Dere\GG17049 Drosophila yakuba Dyak\GE24437 Drosophila ananassae Dana\GF17379 Drosophila pseudoobscura pseudoobscura Dpse\GA22017 Drosophila persimilis Dper\GL23983 Drosophila willistoni Dwil\GK13341 Drosophila virilis Dvir\GJ10735 Drosophila mojavensis Dmoj\GI23239 Drosophila grimshawi Dgri\GH18540
Stocks & Reagents
Stocks Listed in FlyBase ( 8 )
Bloomington	1732 yrt87Ek-7/MRS 31127 y1 v1; P{TRiP.JF01600}attP2 36118 y1 sc* v1; P{TRiP.HMS01532}attP2 31771 y1 sc* v1; P{TRiP.JF03429}attP2/TM3, Sb1 15356 y1 w67c23; P{EPgy2}yrtEY01443/TM3, Sb1 Ser1
Harvard	- PBac{RB}yrte01024
VDRC	v107016 P{KK101638}VIE-260B v28674 w1118; P{GD13224}v28674
Genomic Clones ( 1 )
	BACR06H18 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 82 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD11531 LD33734
Other clones	DPiM_LD33734
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH28412 GM09873 GM09886 GM19755 LD01167 LD04526 LD09035 LD11749 LD13270 LD23468 LD23886 LD35931 LD37260 LD39854 LD43624 RE21603 RE25586 RE33352 RE34123 RE35248 RE41767 RE42838 RE58996 RE60513 SD21329
Other clones	46732 50528 61875 75239 76598 83797 100680 153165 160095 214215.36 214415.48 523702 CK01.9C.G7 CK01.85B.C5 Dmel_dig_014889_0655_3521 Dmel_neb_001026_0888_0376 Dmel_neb_006670_0910_1495 Dmel_neb_015014_0823_1492 EC26994 EC43794 EK012028 EK067511 EK138907 EK165212 EK176345 EK205142 EK218538 EK223235 EK256448 EK269004 EK273302 EN04134 LD24419 LD35542 RP004080462 RP004148759 RP004192929 RP004196638 RP004196844 RP004209487 RP004234442 RP004236757 RP004246821 RP004269290 RP004287031 RP004338956 RP004368956 RP004406999 RP004412220 RP004483035 RP004526844 RP004543030 RP004543469 RP004549848
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0004049 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41656
Antibody Information
	polyclonal (Laprise et al., 2006)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: yrt l(3)87Ek (Hoover and Bryant, 2002)
Additional comments	Three complementation groups.
Other Comments
	dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) Homozygous mutant embryos show a failure in germ-band retraction, dorsal closure and head involution, associated with degeneration of the amnioserosa. (Hoover and Bryant, 2002) Shows particularly robust cycling of transcription in adult heads, as assessed by expression analysis using high density oligonucleotide arrays with probe generated during three 12-point time course experiments over the course of 6 days. (Claridge-Chang et al., 2001) Required for dorsal closure and the completion of terminal development. (Hoover and Bryant, 2000) yrt mutants display failure of posterior dorsal closure. (Jurgens et al., 1984)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_142034 NM_001144572 NM_001144573 NM_001144574 RefSeq (Proteins) • NP_650291 NP_001138044 NP_001138045 NP_001138046 DDBJ / EMBL / GenBank • AA392181 AA941024 AAF54951 AAL28681 AAT94494 ABK63800 ABK63801 AC003923 ACL83502 ACL83503 ACL83504 AW942193 AY061133 BT015265 BZ748831 CZ478855 EF078694 EF078695 Entrez Gene - A searchable database of RefSeq genes. • 41656 UniProtKB/TrEMBL • A0T1Z4 A0T1Z5 B7Z0J2 Q9VFU8 Q95RU5
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • FERM domain (IPR000299) Ezrin/radixin/moesin like (IPR000798) Pleckstrin homology-like domain (IPR011993) FERM/acyl-CoA-binding protein, 3-helical bundle (IPR014352) FERM adjacent (FA) (IPR014847) FERM, C-terminal PH-like domain (IPR018980) FERM, N-terminal (IPR018979) FERM conserved site (IPR019747) FERM central domain (IPR019748) Band 4.1 domain (IPR019749) Band 4.1 family (IPR019750)
Linkouts
	BioGRID - A database of protein and genetic interactions • 66738 DroID - A comprehensive database of gene and protein interactions. • FBgn0004049 DRSC - Results from RNAi screens. • FBgn0004049 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004049 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9764-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0004049 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41656 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41656 modMine - Data generated by the modENCODE project. • FBgn0004049
Synonyms & Secondary IDs ( 13 )
Reported As
Symbol Synonym	CG9764 (Claridge-Chang et al., 2001, Goldstein and Gunawardena, 2000, Giot et al., 2003, Molnar et al., 2006, Keleman et al., 2009.8.5, Ni et al., 2008, Perkins et al., 2009, Ni et al., 2011.7.19) dlhB   l(3)87Ek (McCarron et al., 1994, ) l(3)E19   l(3)m112 (Hoover and Bryant, 2002, Hilliker et al., 1980, Hall and Kankel, 1976, ) m112 (Manseau et al., 1988, Rushlow and Chovnick, 1984, Hilliker et al., 1981) Nbl4 (Hoover and Bryant, 2000) yrt (Sun et al., 2012, Molnar et al., 2006, Bakal et al., 2007, Laprise et al., 2010, Nelson et al., 2010) Yrt (Laprise et al., 2008, Laprise et al., 2009)
Name Synonym	dorsal holes B   lethal(3)87Ek   yurt (Laprise et al., 2006, Laprise et al., 2010, Chen et al., 2010) Yurt (Laprise et al., 2008, Laprise et al., 2009)
Secondary FlyBase IDs
	FBgn0000466 FBgn0002363 FBgn0038155
References ( 47 )
Generate a list of	All references relating to this gene ( 47 )
List References by type	Research paper  ( 20 ) Supplementary material  ( 7 ) Review  ( 1 ) Personal communication to FlyBase  ( 10 ) Abstract  ( 3 ) FlyBase analysis  ( 1 ) Stock list  ( 1 ) Curated genome annotation  ( 2 ) Book  ( 1 )
Recent research papers ( 1 )
	Sun et al., 2012, PLoS Genet. 8(2): e1002515 Neurophysiological Defects and Neuronal Gene Deregulation in Drosophila mir-124 Mutants. [FBrf0217508] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...