Gene Dmel\z

Help

Close All Open All

General Information

Symbol

Dmel\z

Species

D. melanogaster

Name

zeste

Annotation symbol

CG7803

Feature type

protein_coding_gene

FlyBase ID

FBgn0004050

Gene Model Status

Current

Stock availability

105 publicly available

Also Known As

EG:BACH59J11.3

Genomic Location

Chromosome (arm)

Recombination map

1-1.0

Cytogenetic map

3A3-3A3

Sequence location

X:2,341,802..2,344,583 [+]

Genomic Maps

Select View:

modENCODE GBrowse

Summary Information

Automatically generated summary

See sections below for more information

The gene zeste is referred to in FlyBase by the symbol Dmel\z (CG7803, FBgn0004050). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding; sequence-specific DNA binding. There is experimental evidence that it is involved in the biological process: positive regulation of chromatin silencing; positive regulation of transcription, DNA-dependent; ommochrome biosynthetic process. 88 alleles are reported. The phenotypes of these alleles are annotated with: eye; pigment cell. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: ATPase, F1 complex, delta/epsilon subunit; Homeodomain-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages, during early pupal stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval/adult salivary gland, adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1640317_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of z. Gene sequence location is X:2341802..2344583.

External Summaries

Phenotypic Description from the Red Book (Lindsley & Zimm 1992)

Gene/Allele symbols may differ from current usage

z: zeste

The regulatory gene zeste interacts with the white locus as well as with the bithorax and decapentaplegic complexes, changing the phenotypic expression of these loci. z1 was the first mutant allele identified (Gans, 1948, 1953); the homo- or hemizygotes of this neomorphic mutant show a lemon yellow eye color when carrying two paired copies of w+ or of the rightmost w+ alleles [as in z1 w+/z1 w+ females or z1/Y males with a w+ duplication (Jack and Judd, 1979)]. z1 w+/Y males without the duplication, z1/z1 females heterozygous for a w allele belonging to one of the right-hand (zeste-suppressing) subloci, or z+/z1 females are wild type. An intralocus duplication for a right sublocus of white produces mottling in z1 males. z1 eye color develops autonomously in mosaics and in eye-disk transplants. It is not affected by the number of Y chromosomes in the genotype. A third chromosome mutant wo interacts with z1 or z58g to lighten eye color, producing z/z;wo/wo white-eyed females and z/Y;wo/wo males with a slight deviation from wild-type eye color (Rayle, 1969, DIS 44: 98; Kaufman et al., 1973). z1 has no effect on the expression of the white gene in ocelli, testes, or larval Malphigian tubules. The first za mutant was also identified by Gans. These mutants are wild type in za/Y males and za/za, za/Df(1)z, and z+/za females. The heteroallelic combination of z1/za, however, results in yellow-eyed flies. Complementation between wsp and other white alleles does not occur in za mutants, although it does occur in z+ or z1 flies (Babu and Bhat, 1980). za-type alleles, including zae(bx), as well as the partial revertant of z1, z11G3, enhance the mutant phenotype of certain heteroallelic combinations of BXC alleles that show transvection (partial complementation) when paired; z+ and z1, however, do not affect these BXC alleles (Kaufman et al., 1973; Gelbart and Wu, 1982; Mariani et al., 1985; Pirrotta et al., 1987). All zeste mutant alleles tested enhance certain heteroallelic mutant combinations that show transvection in dpp (Gelbart and Wu, 1982). The zop mutants (Lifschytz and Green, 1984), unlike z1, require only one copy of w+ for expression of a zeste eye color in homo- and hemizygotes. Heterozygotes over z+ are zeste if they have two copies of w+, but are wild type if there is only one copy. Another mutant, zv77h, requires only one copy of w+ in males. The eyes are brown variegated in hemi- and homozygous zv77h females and zv77h/Y males, but wild type in homozygous zv77h Dp(1;1)w+2 females and zv77h Dp(1;1)w+2/Y males, this allele responding to an increase in w+ dosage in a manner contrary to that of z1 (Green, 1984). Diepoxy-butane-induced mutations (including multilocus deletions) have been generated in an attempt to obtain a null allele of zeste (Goldberg et al., 1989). Some of the females that were completely deficient for z [Df(1)z-deb3/Df(1)z-deb3, for example] survived and were fertile, indicating that the product of the zeste gene is not required for viability or female fertility.

Two synapsed copies of w+ required for expression of zeste eye color (Gans, 1953). Ocelli wild type in color, as are testes and larval Malpighian tubules. Supports transvection at Ubx but not at dpp.

z11G3

Partial revertant of z1 showing wild-type eye color in hemizygous males and homozygous females (Gans, 1953). Almost complete complementation of z1 eye color. Does not support transvection at dpp or Ubx.

Hemizygous males and homozygous females said to be wild type in eye color (Gans); however, on closer inspection they are seen to have a diluted eye color that becomes brown with age (Pirrotta et al., 1987). z1/za females have zeste eyes; za wDZL/za wch females have light brown eyes. Does not support transvection at dpp or Ubx.

zae(bx)

Mostly wild type, but slight eye color variegation in homozygous females (Lewis, 1959, DIS 33: 96). z1/zae(bx) females zeste. Does not support transvection at dpp or Ubx.

zop6

Eye color zeste in hemizygous males and homozygous females with only one copy of w+; homozygous females with two copies of w+ also zeste. Heterozygous z+/zop6 females wild type if one copy of w+, but zeste if two copies; zop6 reverts to weaker alleles after EMS or X rays (Lifschytz and Green, 1984).

zπ1

Hemizygous males and homo- or hemizygous females almost wild type in eye color. Supports transvection at Ubx (Pirrotta et al., 1987).

zv77h

Eye color diluted, turning brownish with age in hemizygous males and hemi- and homozygous females with a normal complement of w+ genes. za/zv77h females are wild type; z1/zv77h females are zeste; zv77h hemizygous males and homozygous females carrying a w+ duplication in each X are wild type.

Recent Updates

Description

What does this section display?

This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).

What does this section not display?

This section does not currently display links that were removed or gene model changes.

Update Feed

Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.

FB2012_01

Sequence features

HFA18855

BKN30032

Controlled Vocabulary Terms

positive regulation of chromatin silencing

sequence-specific DNA binding

FB2011_10

All updates

Click here to see a list of all updates to this record from FB2010_08 and on.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

3A3-3A3

Limits computationally determined from genome sequence between P{EP}EP1605 and P{EP}CG32796^EP1385&P{EP}EP1160

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

3A4-3A4