Gene model reviewed during 5.49
Gene model reviewed during 5.50
None of the polypeptides share 100% sequence identity.
252 (aa); 28 (kD)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\zen2 using the Feature Mapper tool.
zen2 transcripts are observed between 0 and 6 hrs of embryonic development with a peak at 2-4hrs on northern blots. No zen2 transcripts are observed in postembryonic stages. zen2 transcripts are observed along the dorsal surface of the pre-cellular blastoderm embryo by in situ hybridization. As gastrulation proceeds, they become restricted to the area of the dorsal folds.
Northern analysis of RNA from 0-24 hour embryos indicate that zen2 transcript is expressed in early embryos, and expression peaks at 2-3 hours of embryogenesis. Using radioactive in situ hybridization, zen2 expression is detected in the dorsal surface and the anterior and posterior poles of embryonic cycle 14 embryos. By gastrulation, zen2 expression is restricted to the dorsal surface. During germ band elongation, zen2 transcript is detected in the amnioserosa and a region of the dorsal ectoderm corresponding to the presumptive ptic lobe.
GBrowse - Visual display of RNA-Seq signalsView Dmel\zen2 in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: zen2 CG1048
The homologs of Antp, ftz, Scr, Dfd, Ama, bcd, zen, pb and lab, but not zen2 are all present in D.pseudoobscura.pseudoobscura, in the same linear order and similarly spaced along the chromosome as in D.melanogaster.
Comparative analysis of the homeobox sequences reveals the subdivision of the Antp-type homeobox genes into three classes early in metazoan evolution, one includes Abd-B, the second includes abd-A, Ubx, Antp, Scr, Dfd and ftz, and the third includes zen, zen2, pb and lab.
A transient expression assay has been employed to investigate the potential of homeobox genes to function as transcriptional activators.
Molecular and genetic analysis of the pb locus has been performed.
Simultaneous deletion of both z2 and pb produces only a pb mutant phenotype. Thus absence of z2 function has no discernible effect on development or morphology.