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FB2021_04, released August 17, 2021

Gene: Dmel\zen2

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General Information
Symbol
Dmel\zen2
Species
D. melanogaster
Name
zerknullt-related
Annotation Symbol
CG1048
Feature Type
protein_coding_gene
FlyBase ID
FBgn0004054
Gene Model Status
Current
Stock Availability
8 publicly available
Gene Summary
zerknullt-related (zen2) encodes a member of the Antennapedia Complex (ANT-C), one of two Hox gene complexes. zen2 is similar in sequence and expression to the adjacent zen gene. The two are closely linked and they appear to be duplicate copies with zen being the ancestral member of the pair. Despite its similarity to zen, absence of zen2 function has no discernible effect on development or morphology. [Date last reviewed: 2019-03-21] (FlyBase Gene Snapshot)
All Summaries
Also Known As

z2

Key Links
Genomic Location
Cytogenetic map
84A5-84A5
Sequence location
3R:6,743,135..6,744,136 [-]
Recombination map
3-48
RefSeq locus
NT_033777 REGION:6743135..6744136
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (4 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables DNA-binding transcription factor activity, RNA polymerase II-specific
inferred from biological aspect of ancestor with PANTHER:PTN005228379
(assigned by GO_Central )
(Gaudet et al., 2011)
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding
inferred from biological aspect of ancestor with PANTHER:PTN005228379
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN005228379
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN005228379
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
zerknullt-related (zen2) encodes a member of the Antennapedia Complex (ANT-C), one of two Hox gene complexes. zen2 is similar in sequence and expression to the adjacent zen gene. The two are closely linked and they appear to be duplicate copies with zen being the ancestral member of the pair. Despite its similarity to zen, absence of zen2 function has no discernible effect on development or morphology. [Date last reviewed: 2019-03-21]
Gene Group (FlyBase)
HOX-LIKE HOMEOBOX TRANSCRIPTION FACTORS -
HOX-like (HOXL) homeobox transcription factors are sequence-specific DNA binding proteins that regulate transcription. They encompass transcription factors encoded by the Hox genes of the Antennapedia and the Bithorax gene complexes and genes closely related in sequence. HOXL transcription factors are major regulators of animal development. (Adapted from FBrf0232555).
Protein Function (UniProtKB)
Required for the differentiation of the dorsal-ventral pattern, and does not appear to be involved in the process of segmentation.
(UniProt, P09090)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
z2: zen-2
Simultaneous deletion of both z2 and pb produces only a pb mutant phenotype. Thus absence of z2 function has no discernible effect on development or morphology.
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\zen2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.49

Gene model reviewed during 5.50

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
zen2-RA
FBtr0081671
NM_057446
935
252
zen2-RB
FBtr0290296
NM_001144545
940
232
Additional Transcript Data and Comments
Reported size (kB)

1.1 (northern blot)

(Pultz et al., 1988)

0.9 (northern blot)

(Rushlow et al., 1987)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
zen2-PA
FBpp0081171
29.0
252
4.69
NP_476794
AAF54088
zen2-PB
FBpp0288735
26.7
232
4.99
NP_001138017
ACL83476
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)

252 (aa); 28 (kD)

(Rushlow et al., 1987)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\zen2 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 4 -- 6
dorsal ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
foregut anlage in statu nascendi
(Fisher et al., 2012)
posterior ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
gastrula stage
organism | dorsal
(Rushlow et al., 1987)
embryonic stage 7 -- 8
amnioserosa anlage
(Fisher et al., 2012)
embryonic cycle 14
organism | anterior | dorsal
(Rushlow et al., 1987)
extended germ band stage
amnioserosa
(Rushlow et al., 1987)
dorsal ectoderm | restricted
(Rushlow et al., 1987)
embryonic stage 9
dorsal fold

Comment: reference states 3.5 hr AEL

(Pultz et al., 1988)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
(Pultz et al., 1988, Rushlow et al., 1987)
embryonic stage 1 -- 6
organism
(Pultz et al., 1988)
Additional Descriptive Data

zen2 transcripts are observed between 0 and 6 hrs of embryonic development with a peak at 2-4hrs on northern blots. No zen2 transcripts are observed in postembryonic stages. zen2 transcripts are observed along the dorsal surface of the pre-cellular blastoderm embryo by in situ hybridization. As gastrulation proceeds, they become restricted to the area of the dorsal folds.

(Pultz et al., 1988)

Northern analysis of RNA from 0-24 hour embryos indicate that zen2 transcript is expressed in early embryos, and expression peaks at 2-3 hours of embryogenesis. Using radioactive in situ hybridization, zen2 expression is detected in the dorsal surface and the anterior and posterior poles of embryonic cycle 14 embryos. By gastrulation, zen2 expression is restricted to the dorsal surface. During germ band elongation, zen2 transcript is detected in the amnioserosa and a region of the dorsal ectoderm corresponding to the presumptive ptic lobe.

(Rushlow et al., 1987)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\zen2 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB
EMBL-EBI Single Cell Expression Atlas
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 7-8
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 0 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 19 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of zen2
Transgenic constructs containing regulatory region of zen2
Aberrations (Deficiencies and Duplications) ( 11 )
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (31)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\HOXA3
3 of 15
Yes
Yes
Hsap\HOXB3
3 of 15
Yes
Yes
Hsap\HOXD3
3 of 15
Yes
Yes
Hsap\GSX2
2 of 15
No
No
Hsap\PDX1
2 of 15
No
Yes
Hsap\GBX1
1 of 15
No
No
Hsap\GBX2
1 of 15
No
No
1  
Hsap\GSX1
1 of 15
No
No
Hsap\HOXA1
1 of 15
No
No
Hsap\HOXA2
1 of 15
No
No
1  
Hsap\HOXA4
1 of 15
No
No
Hsap\HOXA5
1 of 15
No
No
1  
Hsap\HOXA6
1 of 15
No
No
Hsap\HOXA7
1 of 15
No
No
Hsap\HOXB1
1 of 15
No
No
Hsap\HOXB2
1 of 15
No
No
1  
Hsap\HOXB4
1 of 15
No
No
Hsap\HOXB5
1 of 15
No
No
1  
Hsap\HOXB6
1 of 15
No
No
Hsap\HOXB7
1 of 15
No
No
Hsap\HOXB8
1 of 15
No
No
Hsap\HOXC4
1 of 15
No
No
Hsap\HOXC5
1 of 15
No
No
Hsap\HOXC6
1 of 15
No
No
Hsap\HOXC8
1 of 15
No
No
1  
Hsap\HOXD1
1 of 15
No
No
Hsap\HOXD4
1 of 15
No
No
2  
Hsap\HOXD8
1 of 15
No
No
Hsap\MEOX1
1 of 15
No
No
Hsap\MEOX2
1 of 15
No
No
Hsap\MNX1
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (31)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Hoxa3
3 of 15
Yes
Yes
Mmus\Hoxb3
3 of 15
Yes
Yes
0  
Mmus\Hoxd3
3 of 15
Yes
Yes
Mmus\Gsx2
2 of 15
No
No
Mmus\Pdx1
2 of 15
No
Yes
Mmus\Barx2
1 of 15
No
No
Mmus\Gbx1
1 of 15
No
No
Mmus\Gbx2
1 of 15
No
No
Mmus\Gsx1
1 of 15
No
No
Mmus\Hoxa1
1 of 15
No
No
Mmus\Hoxa2
1 of 15
No
No
3  
Mmus\Hoxa4
1 of 15
No
No
Mmus\Hoxa5
1 of 15
No
No
3  
Mmus\Hoxa6
1 of 15
No
No
Mmus\Hoxa7
1 of 15
No
No
1  
Mmus\Hoxb1
1 of 15
No
No
0  
Mmus\Hoxb2
1 of 15
No
No
Mmus\Hoxb4
1 of 15
No
No
0  
Mmus\Hoxb5
1 of 15
No
No
Mmus\Hoxb7
1 of 15
No
No
Mmus\Hoxb8
1 of 15
No
No
Mmus\Hoxc4
1 of 15
No
No
Mmus\Hoxc5
1 of 15
No
No
Mmus\Hoxc6
1 of 15
No
No
Mmus\Hoxc8
1 of 15
No
No
Mmus\Hoxd1
1 of 15
No
No
Mmus\Hoxd4
1 of 15
No
No
Mmus\Hoxd8
1 of 15
No
No
Mmus\Meox1
1 of 15
No
No
Mmus\Meox2
1 of 15
No
No
Mmus\Mnx1
1 of 15
No
No
Rattus norvegicus (Norway rat) (35)
Rnor\Hoxa3
3 of 13
Yes
Yes
Rnor\Hoxb3
3 of 13
Yes
Yes
Rnor\Hoxd3
3 of 13
Yes
Yes
Rnor\Gsx2
2 of 13
No
No
Rnor\Pdx1
2 of 13
No
Yes
Rnor\Barx2
1 of 13
No
No
Rnor\Gbx1
1 of 13
No
No
Rnor\Gbx2
1 of 13
No
No
Rnor\Gsx1
1 of 13
No
No
Rnor\Hoxa1
1 of 13
No
No
Rnor\Hoxa2
1 of 13
No
No
Rnor\Hoxa4
1 of 13
No
No
Rnor\Hoxa6
1 of 13
No
No
Rnor\Hoxa7
1 of 13
No
No
Rnor\Hoxb1
1 of 13
No
No
Rnor\Hoxb2
1 of 13
No
No
Rnor\Hoxb4
1 of 13
No
No
Rnor\Hoxb5
1 of 13
No
No
Rnor\Hoxb6
1 of 13
No
No
Rnor\Hoxb7
1 of 13
No
No
Rnor\Hoxb8
1 of 13
No
No
Rnor\Hoxc4
1 of 13
No
No
Rnor\Hoxc5
1 of 13
No
No
Rnor\Hoxc6
1 of 13
No
No
Rnor\Hoxc8
1 of 13
No
No
Rnor\Hoxd1
1 of 13
No
No
Rnor\Hoxd4
1 of 13
No
No
Rnor\LOC100360577
1 of 13
No
No
Rnor\LOC100909604
1 of 13
No
No
Rnor\LOC100911511
1 of 13
No
Yes
Rnor\LOC100911622
1 of 13
No
No
Rnor\Meox1
1 of 13
No
No
Rnor\Meox2
1 of 13
No
No
Rnor\Mnx1
1 of 13
No
No
Rnor\NEWGENE_1587253
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (28)
Xtro\gsx2
2 of 12
Yes
No
Xtro\hoxa3
2 of 12
Yes
Yes
Xtro\hoxb3
2 of 12
Yes
Yes
Xtro\hoxc3
2 of 12
Yes
Yes
Xtro\hoxd3
2 of 12
Yes
Yes
Xtro\gbx2.1
1 of 12
No
No
Xtro\gbx2.2
1 of 12
No
No
Xtro\gsx1
1 of 12
No
No
Xtro\hoxa1
1 of 12
No
No
Xtro\hoxa2
1 of 12
No
No
Xtro\hoxa5
1 of 12
No
No
Xtro\hoxa7
1 of 12
No
No
Xtro\hoxb1
1 of 12
No
No
Xtro\hoxb2
1 of 12
No
No
Xtro\hoxb4
1 of 12
No
No
Xtro\hoxb5
1 of 12
No
No
Xtro\hoxb6
1 of 12
No
No
Xtro\hoxb7
1 of 12
No
No
Xtro\hoxb8
1 of 12
No
No
Xtro\hoxc4
1 of 12
No
No
Xtro\hoxc5
1 of 12
No
No
Xtro\hoxc8
1 of 12
No
No
Xtro\hoxd1
1 of 12
No
No
Xtro\hoxd4
1 of 12
No
No
Xtro\hoxd8
1 of 12
No
No
Xtro\meox2
1 of 12
No
No
Xtro\mnx1
1 of 12
No
No
Xtro\pdx1
1 of 12
No
No
Danio rerio (Zebrafish) (33)
Drer\hoxa3a
3 of 15
Yes
Yes
Drer\hoxb3a
3 of 15
Yes
Yes
Drer\hoxc3a
3 of 15
Yes
Yes
Drer\hoxd3a
3 of 15
Yes
Yes
Drer\pdx1
3 of 15
Yes
Yes
Drer\gsx2
2 of 15
No
No
Drer\gbx1
1 of 15
No
No
Drer\gbx2
1 of 15
No
No
Drer\gsx1
1 of 15
No
No
1  
Drer\hoxa1a
1 of 15
No
No
Drer\hoxa2b
1 of 15
No
No
Drer\hoxa5a
1 of 15
No
No
Drer\hoxb1a
1 of 15
No
No
Drer\hoxb2a
1 of 15
No
No
Drer\hoxb4a
1 of 15
No
No
Drer\hoxb5a
1 of 15
No
No
Drer\hoxb5b
1 of 15
No
No
Drer\hoxb6a
1 of 15
No
No
Drer\hoxb6b
1 of 15
No
No
Drer\hoxb7a
1 of 15
No
No
Drer\hoxb8a
1 of 15
No
No
Drer\hoxb8b
1 of 15
No
No
Drer\hoxc1a
1 of 15
No
No
Drer\hoxc4a
1 of 15
No
No
Drer\hoxc6b
1 of 15
No
No
Drer\hoxc8a
1 of 15
No
No
Drer\hoxd4a
1 of 15
No
No
Drer\meox1
1 of 15
No
No
Drer\meox2a
1 of 15
No
No
Drer\meox2b
1 of 15
No
No
Drer\mnx1
1 of 15
No
No
Drer\mnx2a
1 of 15
No
No
Drer\pnx
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (7)
Cele\ceh-10
1 of 15
Yes
No
Cele\ceh-12
1 of 15
Yes
No
Cele\ceh-13
1 of 15
Yes
No
0  
Cele\ceh-62
1 of 15
Yes
No
Cele\ceh-63
1 of 15
Yes
No
Cele\egl-5
1 of 15
Yes
No
Cele\mab-5
1 of 15
Yes
No
Arabidopsis thaliana (thale-cress) (9)
Atha\HAT1
1 of 9
Yes
No
Atha\HAT3
1 of 9
Yes
Yes
Atha\HAT22
1 of 9
Yes
No
Atha\HB-1
1 of 9
Yes
No
Atha\HB4
1 of 9
Yes
No
Atha\HB5
1 of 9
Yes
No
Atha\HB6
1 of 9
Yes
Yes
Atha\HB-7
1 of 9
Yes
No
Atha\HB16
1 of 9
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\YOX1
1 of 15
Yes
No
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190HSD )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila simulans
Dsim\GD19524
Drosophila sechellia
Dsec\GM10529
Drosophila erecta
Dere\GG10258
Drosophila yakuba
Dyak\GE25832
Drosophila ananassae
Dana\GF17797
Drosophila pseudoobscura pseudoobscura
Dpse\GA10340
Drosophila persimilis
Dper\GL21773
Drosophila willistoni
Dwil\GK12250
Drosophila virilis
Dvir\GJ23303
Drosophila mojavensis
Dmoj\GI22889
Drosophila mojavensis
Dmoj\GI13996
Drosophila grimshawi
Dgri\GH18130
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150DQ3 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17025180
Musca domestica
House fly
Mdoa\17025181
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_01939
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( None identified )
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( None identified )
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0PFO )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Hox11/13b
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Hox3
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Mox_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Mox
Ciona intestinalis
Vase tunicate
Cint\hox3
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000007464
Gallus gallus
Domestic chicken
Ggal\MNX1
Gallus gallus
Domestic chicken
Ggal\MEOX2
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000027925
Gallus gallus
Domestic chicken
Ggal\HOXA3
Gallus gallus
Domestic chicken
Ggal\GGMOXr1
Gallus gallus
Domestic chicken
Ggal\HOXD3
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (18)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
bcd
3 of 10
pb
3 of 10
zen
3 of 10
abd-A
2 of 10
Dfd
2 of 10
ftz
2 of 10
ind
2 of 10
lab
2 of 10
ro
2 of 10
Scr
2 of 10
Abd-B
1 of 10
Antp
1 of 10
btn
1 of 10
CG30480
1 of 10
exex
1 of 10
inv
1 of 10
Ubx
1 of 10
unpg
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    HOXA3; homeobox A3
    3 of 15
    142954
        HOXB3; homeobox B3
        3 of 15
        142966
            HOXD3; homeobox D3
            3 of 15
            142980
                Functional Complementation Data
                Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                Interactions
                Summary of Physical Interactions
                esyN Network Diagram
                Interactions Browser
                Summary of Genetic Interactions
                esyN Network Diagram
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                External Data
                Linkouts
                DroID - A comprehensive database of gene and protein interactions.
                Pathways
                Signaling Pathways (FlyBase)
                Metabolic Pathways
                External Data
                Linkouts
                Genomic Location and Detailed Mapping Data
                Chromosome (arm)
                3R
                Recombination map
                3-48
                Cytogenetic map
                84A5-84A5
                Sequence location
                3R:6,743,135..6,744,136 [-]
                FlyBase Computed Cytological Location
                Cytogenetic map
                Evidence for location
                84A5-84A5
                Limits computationally determined from genome sequence between P{PZ}pb04498 and P{lacW}l(3)L2100L2100
                Experimentally Determined Cytological Location
                Cytogenetic map
                Notes
                References
                84A1-84A1
                (determined by in situ hybridisation)
                (Rushlow et al., 1987)
                84A-84B
                (determined by in situ hybridisation)
                (Rushlow et al., 1987)
                Experimentally Determined Recombination Data
                Location

                3-48

                (FlyBase, 2016)

                3-44.2

                (Comeron et al., 2012)

                3-47.5

                Left of (cM)
                Right of (cM)
                Notes

                Map position inferred from close proximity to zen.

                Stocks and Reagents
                Stocks (8)
                Genomic Clones (32)
                cDNA Clones (21)
                 

                Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                cDNA clones, fully sequenced
                BDGP DGC clones
                  Other clones
                  Drosophila Genomics Resource Center cDNA clones

                  For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                  cDNA Clones, End Sequenced (ESTs)
                  BDGP DGC clones
                    Other clones
                    RNAi and Array Information
                    Linkouts
                    DRSC - Results frm RNAi screens
                    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                    Antibody Information
                    Laboratory Generated Antibodies
                     
                    Commercially Available Antibodies
                     
                    Other Information
                    Relationship to Other Genes
                    Source for database identify of

                    Source for identity of: zen2 CG1048

                    (Li, 1999.11)
                    Source for database merge of
                    Additional comments
                    Other Comments

                    The homologs of Antp, ftz, Scr, Dfd, Ama, bcd, zen, pb and lab, but not zen2 are all present in D.pseudoobscura.pseudoobscura, in the same linear order and similarly spaced along the chromosome as in D.melanogaster.

                    (Randazzo et al., 1993)

                    Comparative analysis of the homeobox sequences reveals the subdivision of the Antp-type homeobox genes into three classes early in metazoan evolution, one includes Abd-B, the second includes abd-A, Ubx, Antp, Scr, Dfd and ftz, and the third includes zen, zen2, pb and lab.

                    (Schubert et al., 1993)

                    No mutations corresponding to zen2 or deficiency exhibit a detectable phenotype so the function of zen2 is unknown.

                    (Kaufman et al., 1990)

                    A transient expression assay has been employed to investigate the potential of homeobox genes to function as transcriptional activators.

                    (Han et al., 1989)

                    Molecular and genetic analysis of the pb locus has been performed.

                    (Pultz et al., 1988)

                    Simultaneous deletion of both z2 and pb produces only a pb mutant phenotype. Thus absence of z2 function has no discernible effect on development or morphology.

                    Origin and Etymology
                    Discoverer
                    Etymology
                    Identification
                    External Crossreferences and Linkouts ( 34 )
                    Sequence Crossreferences
                    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                    Other crossreferences
                    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                    DRscDB
                    EMBL-EBI Single Cell Expression Atlas
                    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                    Flygut - An atlas of the Drosophila adult midgut
                    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                    InterPro - A database of protein families, domains and functional sites
                    KEGG Genes - Molecular building blocks of life in the genomic space.
                    MARRVEL_MODEL
                    modMine - A data warehouse for the modENCODE project
                    Linkouts
                    DroID - A comprehensive database of gene and protein interactions.
                    DRSC - Results frm RNAi screens
                    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                    FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                    FlyMine - An integrated database for Drosophila genomics
                    Synonyms and Secondary IDs (9)
                    Datasets (0)
                    Study focus (0)
                    Experimental Role
                    Project
                    Project Type
                    Title
                    References (83)