Pros28.1, α4, Pros28, Proteasome 28kD subunit 1, α4_dm
Gene model reviewed during 5.39
Gene model reviewed during 5.52
There is only one protein coding transcript and one polypeptide associated with this gene
The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity). Interacts with PI31; this interaction is reduced by PI31 ADP-ribosylation.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Prosα4 using the Feature Mapper tool.
Prosα4 expression is observed in the brain and ventral nerve cord in third instar larvae as well as in the ring gland. In eye disc, expression is mainly seen anterior to the morphogenetic furrow, whereas in the antennal disc, transcript distribution is more uniform. A modlulated pattern is seen in the wing and leg discs.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Prosα4 in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: Prosα4 Pros28.1
The nomenclature of genes encoding subunits of the 26S proteasome of D. melanogaster have been standardized according to FBrf0215459. These symbols/names largely follow those used already in FlyBase, and largely mirror fly community usage. HOWEVER, note that at least one other nomenclature system exists that is followed by the HUGO Gene Nomenclature Committee (HGNC), for example, with the unfortunate result that several D. melanogaster genes have shared synonyms.
The Pros28.1 gene has been cloned and sequenced, and its genomic organisation has been analysed.
Only divergence between Arabidopsis and Drosophila Pros28 gene is in the 20 C-terminal amino acids.
The cellular distribution of the proteasome during embryogenesis has been investigated using an antibody that cross-reacts strongly with a number of the 28kD proteasome subunits.