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Gene Dmel\Prosα4

General Information
Symbol	Dmel\Prosα4	Species	D. melanogaster
Name	Proteasome α4 subunit	Annotation symbol	CG3422
Feature type	protein_coding_gene	FlyBase ID	FBgn0004066
Gene Model Status	Current	Stock availability	5 publicly available
Also Known As	pros28.1, α4, PROS-Dm28.1, α4_dm
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	14B7-14B7	Sequence location	X:16,170,305..16,171,620 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Proteasome α4 subunit is referred to in FlyBase by the symbol Dmel\Prosα4 (CG3422, FBgn0004066). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: endopeptidase activity. There is experimental evidence that it is involved in the biological process: response to DNA damage stimulus. 5 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Proteasome A-type subunit; Proteasome, alpha-subunit, N-terminal domain; Proteasome, subunit alpha/beta. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 00-06 hour embryonic stages, during late larval stages, during early pupal stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, adult crop, larval/adult midgut, larval hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult hindgut, adult salivary gland, adult testis. Comments on Affy2 ProbeSet: ProbeSet 1641485_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Pros28.1. Gene sequence location is X:16170305..16171620.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 14B7-14B7   Limits computationally determined from genome sequence between P{EP}kat80EP620&P{EP}cazEP1564 and P{EP}Cyp1EP1073&P{EP}Dsp1EP355
Experimentally Determined Cytological Location
Cytogenetic map Notes References 14B4-14B4   (determined by in situ hybridisation)   (Frentzel et al., 1992)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Prosα4 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.39
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Prosα4-RA FBtr0074210  NM_080353   1174   249
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Prosα4-PA   FBpp0073989   28.0   249   8.30     NP_525092   AAF48573
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Proteasome, alpha-subunit, N-terminal domain (IPR000426) Proteasome, subunit alpha/beta (IPR001353) Proteasome A-type subunit (IPR023332) MEROPS - An information resource for peptidases and the proteins that inhibit them • T01.974
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA439183   AA979010   AE014298 AAF48573   AY071241 AAL48863   AY542383 AAS86210   AY542384 AAS86211   AY542385 AAS86212   AY542386 AAS86213   AY542387 AAS86214   AY542388 AAS86215   AY542389 AAS86216   BG638699   BI232157   BI353608   BI364606   BI578880   BI636169   BI636816   BP553399   BP553400   BX041485   BX052025   CO178755   CO186266   CO196209   CO278952   CO295689   CO305740   CO310502   CO323756   CO329262   CO330073   EC068602   EC078810   EC086168   EC088808   EC088850   EC090309   EC201524   EC213462   EC244568   ES696625   EV587791   EV588589   GH748939   GH753338   GH755293   GH755556   GH756620   GH761032   GH770740   GH774553   GH774775   GH780735   GH791805   GH792038   GH793228   GH795675   GH798920   GH804273   GH805671   GH811108   GH813410   GH814800   GH815496   GH816789   GH816990   GH823512   GH828519   GH832885   GH835630   GH841709   GH845442   GH853151   GH856188   GH858953   GH871720   GH873388   GH876115   GH883844   GH885080   GH885768   GH896603   GH901015   GH901114   GH903246   GH904572   GH904888   GH906380   GH907030   GH908866   GH909698   GH913400   GH916299   GH917525   GH925747   GH926159   GH933583   M57712 AAA62768   X62286 CAA44174
UniProtKB/Swiss-Prot	P22769
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   anterior endoderm anlage   (Fisher et al., 2012) head mesoderm   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) pole cell   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) embryonic stage 9 -- 10   anterior endoderm   (Fisher et al., 2012) germline cell   (Fisher et al., 2012) head mesoderm   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) embryonic stage 11 -- 12   anterior midgut primordium   (Fisher et al., 2012) germline cell   (Fisher et al., 2012) head mesoderm   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) posterior midgut primordium   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic brain   (Fisher et al., 2012) embryonic/larval fat body   (Fisher et al., 2012) embryonic/larval midgut   (Fisher et al., 2012) embryonic/larval muscle system   (Fisher et al., 2012) germline cell   (Fisher et al., 2012) gonad   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
microtubule associated complex inferred from direct assay (Hughes et al., 2008) proteasome core complex inferred from direct assay (Sumegi et al., 2003)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, adult crop, larval/adult midgut, larval hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult hindgut, adult salivary gland, adult testis. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    639.6 Larval Midgut    736.2 Larval Hindgut    683.6 Larval Malpighian Tubules    1491.3 Larval Fat Body    704.5 Larval Salivary Gland    993.1 Larval Trachea    678.075 Larval Carcass    1084.95 Adult Head    305.3 Adult Eye    240.725 Adult Brain    171 Adult Thoracic-Abdominal Ganglion    256.8 Adult Crop    509.3 Adult Midgut    503.6 Adult Hindgut    328.2 Adult Malpighian Tubules    612.2 Adult Fat Body    1082.1 Adult Salivary Gland    401.2 Adult Heart    1175.2 Adult VirginFemale Spermatheca    562.2 Adult InseminatedFemale Spermatheca    510.2 Adult Ovary    971.3 Adult Testis    178 Adult Male Accessory Gland    550.5 Adult Carcass    921.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (639.6) Larval Midgut  (736.2) Larval Hindgut  (683.6) Larval Malpighian Tubules  (1491.3) Larval Fat Body  (704.5) Larval Salivary Gland  (993.1) Larval Trachea  (678.075) Larval Carcass  (1084.95) Adult Head    305.3 Adult Eye    240.725 Adult Brain    171 Adult Thoracic-Abdominal Ganglion    256.8 Adult Crop  509.3 Adult Midgut  503.6 Adult Hindgut    328.2 Adult Malpighian Tubules  (612.2) Adult Fat Body  (1082.1) Adult Salivary Gland    401.2 Adult Heart  (1175.2) Adult VirginFemale Spermatheca  (562.2) Adult InseminatedFemale Spermatheca  510.2 Adult Ovary  (971.3) Adult Testis    178 Adult Male Accessory Gland  (550.5) Adult Carcass  (921.1) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    639.6 Larval Midgut    736.2 Larval Hindgut    683.6 Larval Malpighian Tubules  (1491.3) Larval Fat Body    704.5 Larval Salivary Gland    993.1 Larval Trachea    678.075 Larval Carcass  (1084.95) Adult Head    305.3 Adult Eye    240.725 Adult Brain    171 Adult Thoracic-Abdominal Ganglion    256.8 Adult Crop    509.3 Adult Midgut    503.6 Adult Hindgut    328.2 Adult Malpighian Tubules    612.2 Adult Fat Body  (1082.1) Adult Salivary Gland    401.2 Adult Heart  (1175.2) Adult VirginFemale Spermatheca    562.2 Adult InseminatedFemale Spermatheca    510.2 Adult Ovary    971.3 Adult Testis    178 Adult Male Accessory Gland    550.5 Adult Carcass    921.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    639.6 Larval Midgut    736.2 Larval Hindgut    683.6 Larval Malpighian Tubules    1491.3 Larval Fat Body    704.5 Larval Salivary Gland    993.1 Larval Trachea    678.075 Larval Carcass    1084.95 Adult Head    305.3 Adult Eye    240.725 Adult Brain    171 Adult Thoracic-Abdominal Ganglion    256.8 Adult Crop    509.3 Adult Midgut    503.6 Adult Hindgut    328.2 Adult Malpighian Tubules    612.2 Adult Fat Body    1082.1 Adult Salivary Gland    401.2 Adult Heart    1175.2 Adult VirginFemale Spermatheca    562.2 Adult InseminatedFemale Spermatheca    510.2 Adult Ovary    971.3 Adult Testis    178 Adult Male Accessory Gland    550.5 Adult Carcass    921.1 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    639.6 Larval Midgut    736.2 Larval Hindgut    683.6 Larval Malpighian Tubules    1491.3 Larval Fat Body    704.5 Larval Salivary Gland    993.1 Larval Trachea    678.075 Larval Carcass    1084.95 Adult Head    305.3 Adult Eye    240.725 Adult Brain    171 Adult Thoracic-Abdominal Ganglion    256.8 Adult Crop    509.3 Adult Midgut    503.6 Adult Hindgut    328.2 Adult Malpighian Tubules    612.2 Adult Fat Body    1082.1 Adult Salivary Gland    401.2 Adult Heart    1175.2 Adult VirginFemale Spermatheca    562.2 Adult InseminatedFemale Spermatheca    510.2 Adult Ovary    971.3 Adult Testis    178 Adult Male Accessory Gland    550.5 Adult Carcass    921.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  639.6 Larval Midgut  736.2 Larval Hindgut  683.6 Larval Malpighian Tubules  (1491.3) Larval Fat Body  704.5 Larval Salivary Gland  (993.1) Larval Trachea  678.075 Larval Carcass  (1084.95) Adult Head    305.3 Adult Eye    240.725 Adult Brain    171 Adult Thoracic-Abdominal Ganglion    256.8 Adult Crop  509.3 Adult Midgut  503.6 Adult Hindgut    328.2 Adult Malpighian Tubules  612.2 Adult Fat Body  (1082.1) Adult Salivary Gland    401.2 Adult Heart  (1175.2) Adult VirginFemale Spermatheca  562.2 Adult InseminatedFemale Spermatheca  510.2 Adult Ovary  (971.3) Adult Testis    178 Adult Male Accessory Gland  550.5 Adult Carcass  (921.1) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    639.6 Larval Midgut    736.2 Larval Hindgut    683.6 Larval Malpighian Tubules  1491.3 Larval Fat Body    704.5 Larval Salivary Gland    993.1 Larval Trachea    678.075 Larval Carcass  1084.95 Adult Head    305.3 Adult Eye    240.725 Adult Brain    171 Adult Thoracic-Abdominal Ganglion    256.8 Adult Crop    509.3 Adult Midgut    503.6 Adult Hindgut    328.2 Adult Malpighian Tubules    612.2 Adult Fat Body  1082.1 Adult Salivary Gland    401.2 Adult Heart  1175.2 Adult VirginFemale Spermatheca    562.2 Adult InseminatedFemale Spermatheca    510.2 Adult Ovary    971.3 Adult Testis    178 Adult Male Accessory Gland    550.5 Adult Carcass    921.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    639.6 Larval Midgut    736.2 Larval Hindgut    683.6 Larval Malpighian Tubules    1491.3 Larval Fat Body    704.5 Larval Salivary Gland    993.1 Larval Trachea    678.075 Larval Carcass    1084.95 Adult Head    305.3 Adult Eye    240.725 Adult Brain    171 Adult Thoracic-Abdominal Ganglion    256.8 Adult Crop    509.3 Adult Midgut    503.6 Adult Hindgut    328.2 Adult Malpighian Tubules    612.2 Adult Fat Body    1082.1 Adult Salivary Gland    401.2 Adult Heart    1175.2 Adult VirginFemale Spermatheca    562.2 Adult InseminatedFemale Spermatheca    510.2 Adult Ovary    971.3 Adult Testis    178 Adult Male Accessory Gland    550.5 Adult Carcass    921.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    305.3   NA  Eye    240.725   NA  Brain    171   639.6  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    256.8   NA  Crop    509.3   736.2  Midgut    503.6   683.6  Hindgut    328.2   1491.3  Malpighian Tubules    612.2   704.5  Fat Body    1082.1   993.1  Salivary Gland    401.2   NA  Heart    1175.2   678.075  Trachea    NA   NA  VirginFemale Spermatheca    562.2   NA  InseminatedFemale Spermatheca    510.2   NA  Ovary    971.3   NA  Testis    178   NA  Male Accessory Gland    550.5   1084.95  Carcass    921.1 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    70 central nervous system, larvae L3    87 central nervous system, pupae P8    36 head, virgin 1-day female    21 head, virgin 4-day female    17 head, virgin 20-day female    15 head, mated 1-day female    18 head, mated 4-day female    25 head, mated 20-day female    19 head, mated 1-day male    21 head, mated 4-day male    35 head, mated 20-day male    49 salivary gland, larvae L3 wandering    38 salivary gland, white prepupae    27 digestive system, larvae L3 wandering    142 digestive system, 1-day adult    58 digestive system, 4-day adult    62 digestive system, 20-day adult    39 fat body, larvae L3 wandering    25 fat body, white prepupae    57 fat body, pupae P8    35 carcass, larvae L3 wandering    184 carcass, 1-day adult    46 carcass, 4-day adult    65 carcass, 20-day adult    48 ovary, virgin 4-day female    150 ovary, mated 4-day female    144 testis, mated 4-day male    54 accessory gland, mated 4-day male    31 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (70) central nervous system, larvae L3  (87) central nervous system, pupae P8  (36) head, virgin 1-day female    21 head, virgin 4-day female    17 head, virgin 20-day female    15 head, mated 1-day female    18 head, mated 4-day female    25 head, mated 20-day female    19 head, mated 1-day male    21 head, mated 4-day male  (35) head, mated 20-day male  (49) salivary gland, larvae L3 wandering  (38) salivary gland, white prepupae  (27) digestive system, larvae L3 wandering  (142) digestive system, 1-day adult  (58) digestive system, 4-day adult  (62) digestive system, 20-day adult  (39) fat body, larvae L3 wandering    25 fat body, white prepupae  (57) fat body, pupae P8  (35) carcass, larvae L3 wandering  (184) carcass, 1-day adult  (46) carcass, 4-day adult  (65) carcass, 20-day adult  (48) ovary, virgin 4-day female  (150) ovary, mated 4-day female  (144) testis, mated 4-day male  (54) accessory gland, mated 4-day male  (31) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    70 central nervous system, larvae L3    87 central nervous system, pupae P8    36 head, virgin 1-day female    21 head, virgin 4-day female    17 head, virgin 20-day female    15 head, mated 1-day female    18 head, mated 4-day female    25 head, mated 20-day female    19 head, mated 1-day male    21 head, mated 4-day male    35 head, mated 20-day male    49 salivary gland, larvae L3 wandering    38 salivary gland, white prepupae    27 digestive system, larvae L3 wandering  (142) digestive system, 1-day adult    58 digestive system, 4-day adult    62 digestive system, 20-day adult    39 fat body, larvae L3 wandering    25 fat body, white prepupae    57 fat body, pupae P8    35 carcass, larvae L3 wandering  (184) carcass, 1-day adult    46 carcass, 4-day adult    65 carcass, 20-day adult    48 ovary, virgin 4-day female  (150) ovary, mated 4-day female  (144) testis, mated 4-day male    54 accessory gland, mated 4-day male    31 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    70 central nervous system, larvae L3    87 central nervous system, pupae P8    36 head, virgin 1-day female    21 head, virgin 4-day female    17 head, virgin 20-day female    15 head, mated 1-day female    18 head, mated 4-day female    25 head, mated 20-day female    19 head, mated 1-day male    21 head, mated 4-day male    35 head, mated 20-day male    49 salivary gland, larvae L3 wandering    38 salivary gland, white prepupae    27 digestive system, larvae L3 wandering    142 digestive system, 1-day adult    58 digestive system, 4-day adult    62 digestive system, 20-day adult    39 fat body, larvae L3 wandering    25 fat body, white prepupae    57 fat body, pupae P8    35 carcass, larvae L3 wandering    184 carcass, 1-day adult    46 carcass, 4-day adult    65 carcass, 20-day adult    48 ovary, virgin 4-day female    150 ovary, mated 4-day female    144 testis, mated 4-day male    54 accessory gland, mated 4-day male    31 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    70 central nervous system, larvae L3    87 central nervous system, pupae P8    36 head, virgin 1-day female    21 head, virgin 4-day female    17 head, virgin 20-day female    15 head, mated 1-day female    18 head, mated 4-day female    25 head, mated 20-day female    19 head, mated 1-day male    21 head, mated 4-day male    35 head, mated 20-day male    49 salivary gland, larvae L3 wandering    38 salivary gland, white prepupae    27 digestive system, larvae L3 wandering    142 digestive system, 1-day adult    58 digestive system, 4-day adult    62 digestive system, 20-day adult    39 fat body, larvae L3 wandering    25 fat body, white prepupae    57 fat body, pupae P8    35 carcass, larvae L3 wandering    184 carcass, 1-day adult    46 carcass, 4-day adult    65 carcass, 20-day adult    48 ovary, virgin 4-day female    150 ovary, mated 4-day female    144 testis, mated 4-day male    54 accessory gland, mated 4-day male    31 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (70) central nervous system, larvae L3  (87) central nervous system, pupae P8  (36) head, virgin 1-day female    21 head, virgin 4-day female    17 head, virgin 20-day female    15 head, mated 1-day female    18 head, mated 4-day female    25 head, mated 20-day female    19 head, mated 1-day male    21 head, mated 4-day male  (35) head, mated 20-day male  (49) salivary gland, larvae L3 wandering  (38) salivary gland, white prepupae  27 digestive system, larvae L3 wandering  (142) digestive system, 1-day adult  (58) digestive system, 4-day adult  (62) digestive system, 20-day adult  (39) fat body, larvae L3 wandering    25 fat body, white prepupae  (57) fat body, pupae P8  (35) carcass, larvae L3 wandering  (184) carcass, 1-day adult  (46) carcass, 4-day adult  (65) carcass, 20-day adult  (48) ovary, virgin 4-day female  (150) ovary, mated 4-day female  (144) testis, mated 4-day male  (54) accessory gland, mated 4-day male  31 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    70 central nervous system, larvae L3    87 central nervous system, pupae P8    36 head, virgin 1-day female    21 head, virgin 4-day female    17 head, virgin 20-day female    15 head, mated 1-day female    18 head, mated 4-day female    25 head, mated 20-day female    19 head, mated 1-day male    21 head, mated 4-day male    35 head, mated 20-day male    49 salivary gland, larvae L3 wandering    38 salivary gland, white prepupae    27 digestive system, larvae L3 wandering  142 digestive system, 1-day adult    58 digestive system, 4-day adult    62 digestive system, 20-day adult    39 fat body, larvae L3 wandering    25 fat body, white prepupae    57 fat body, pupae P8    35 carcass, larvae L3 wandering  (184) carcass, 1-day adult    46 carcass, 4-day adult    65 carcass, 20-day adult    48 ovary, virgin 4-day female  (150) ovary, mated 4-day female  (144) testis, mated 4-day male    54 accessory gland, mated 4-day male    31 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    70 central nervous system, larvae L3    87 central nervous system, pupae P8    36 head, virgin 1-day female    21 head, virgin 4-day female    17 head, virgin 20-day female    15 head, mated 1-day female    18 head, mated 4-day female    25 head, mated 20-day female    19 head, mated 1-day male    21 head, mated 4-day male    35 head, mated 20-day male    49 salivary gland, larvae L3 wandering    38 salivary gland, white prepupae    27 digestive system, larvae L3 wandering    142 digestive system, 1-day adult    58 digestive system, 4-day adult    62 digestive system, 20-day adult    39 fat body, larvae L3 wandering    25 fat body, white prepupae    57 fat body, pupae P8    35 carcass, larvae L3 wandering    184 carcass, 1-day adult    46 carcass, 4-day adult    65 carcass, 20-day adult    48 ovary, virgin 4-day female    150 ovary, mated 4-day female    144 testis, mated 4-day male    54 accessory gland, mated 4-day male    31 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 00-06 hour embryonic stages, during late larval stages, during early pupal stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    376 embryo 02-04hr    383 embryo 04-06hr    96 embryo 06-08hr    88 embryo 08-10hr    113 embryo 10-12hr    120 embryo 12-14hr    61 embryo 14-16hr    64 embryo 16-18hr    43 embryo 18-20hr    28 embryo 20-22hr    29 embryo 22-24hr    29 larva L1    52 larva L2    124 larva L3 12hr old    98 larva L3 puffstage 1-2    141 larva L3 puffstage 3-6    226 larva L3 puffstage 7-9    313 white prepupae new    275 white prepupae 12hr    115 white prepupae 24hr    123 pupae 2d postWPP    76 pupae 3d postWPP    59 pupae 4d postWPP    124 adult male 01day    75 adult male 05day    76 adult male 30day    75 adult female 01day    168 adult female 05day    217 adult female 30day    222 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (376) embryo 02-04hr  (383) embryo 04-06hr  (96) embryo 06-08hr  (88) embryo 08-10hr  (113) embryo 10-12hr  (120) embryo 12-14hr  (61) embryo 14-16hr  (64) embryo 16-18hr  (43) embryo 18-20hr  (28) embryo 20-22hr  (29) embryo 22-24hr  (29) larva L1  (52) larva L2  (124) larva L3 12hr old  (98) larva L3 puffstage 1-2  (141) larva L3 puffstage 3-6  (226) larva L3 puffstage 7-9  (313) white prepupae new  (275) white prepupae 12hr  (115) white prepupae 24hr  (123) pupae 2d postWPP  (76) pupae 3d postWPP  (59) pupae 4d postWPP  (124) adult male 01day  (75) adult male 05day  (76) adult male 30day  (75) adult female 01day  (168) adult female 05day  (217) adult female 30day  (222) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (376) embryo 02-04hr  (383) embryo 04-06hr    96 embryo 06-08hr    88 embryo 08-10hr  (113) embryo 10-12hr  (120) embryo 12-14hr    61 embryo 14-16hr    64 embryo 16-18hr    43 embryo 18-20hr    28 embryo 20-22hr    29 embryo 22-24hr    29 larva L1    52 larva L2  (124) larva L3 12hr old    98 larva L3 puffstage 1-2  (141) larva L3 puffstage 3-6  (226) larva L3 puffstage 7-9  (313) white prepupae new  (275) white prepupae 12hr  (115) white prepupae 24hr  (123) pupae 2d postWPP    76 pupae 3d postWPP    59 pupae 4d postWPP  (124) adult male 01day    75 adult male 05day    76 adult male 30day    75 adult female 01day  (168) adult female 05day  (217) adult female 30day  (222) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    376 embryo 02-04hr    383 embryo 04-06hr    96 embryo 06-08hr    88 embryo 08-10hr    113 embryo 10-12hr    120 embryo 12-14hr    61 embryo 14-16hr    64 embryo 16-18hr    43 embryo 18-20hr    28 embryo 20-22hr    29 embryo 22-24hr    29 larva L1    52 larva L2    124 larva L3 12hr old    98 larva L3 puffstage 1-2    141 larva L3 puffstage 3-6    226 larva L3 puffstage 7-9    313 white prepupae new    275 white prepupae 12hr    115 white prepupae 24hr    123 pupae 2d postWPP    76 pupae 3d postWPP    59 pupae 4d postWPP    124 adult male 01day    75 adult male 05day    76 adult male 30day    75 adult female 01day    168 adult female 05day    217 adult female 30day    222 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    376 embryo 02-04hr    383 embryo 04-06hr    96 embryo 06-08hr    88 embryo 08-10hr    113 embryo 10-12hr    120 embryo 12-14hr    61 embryo 14-16hr    64 embryo 16-18hr    43 embryo 18-20hr    28 embryo 20-22hr    29 embryo 22-24hr    29 larva L1    52 larva L2    124 larva L3 12hr old    98 larva L3 puffstage 1-2    141 larva L3 puffstage 3-6    226 larva L3 puffstage 7-9    313 white prepupae new    275 white prepupae 12hr    115 white prepupae 24hr    123 pupae 2d postWPP    76 pupae 3d postWPP    59 pupae 4d postWPP    124 adult male 01day    75 adult male 05day    76 adult male 30day    75 adult female 01day    168 adult female 05day    217 adult female 30day    222 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (376) embryo 02-04hr  (383) embryo 04-06hr  (96) embryo 06-08hr  (88) embryo 08-10hr  (113) embryo 10-12hr  (120) embryo 12-14hr  (61) embryo 14-16hr  (64) embryo 16-18hr  (43) embryo 18-20hr  28 embryo 20-22hr  29 embryo 22-24hr  29 larva L1  (52) larva L2  (124) larva L3 12hr old  (98) larva L3 puffstage 1-2  (141) larva L3 puffstage 3-6  (226) larva L3 puffstage 7-9  (313) white prepupae new  (275) white prepupae 12hr  (115) white prepupae 24hr  (123) pupae 2d postWPP  (76) pupae 3d postWPP  (59) pupae 4d postWPP  (124) adult male 01day  (75) adult male 05day  (76) adult male 30day  (75) adult female 01day  (168) adult female 05day  (217) adult female 30day  (222) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (376) embryo 02-04hr  (383) embryo 04-06hr    96 embryo 06-08hr    88 embryo 08-10hr  113 embryo 10-12hr  120 embryo 12-14hr    61 embryo 14-16hr    64 embryo 16-18hr    43 embryo 18-20hr    28 embryo 20-22hr    29 embryo 22-24hr    29 larva L1    52 larva L2  124 larva L3 12hr old    98 larva L3 puffstage 1-2  141 larva L3 puffstage 3-6  (226) larva L3 puffstage 7-9  (313) white prepupae new  (275) white prepupae 12hr  115 white prepupae 24hr  123 pupae 2d postWPP    76 pupae 3d postWPP    59 pupae 4d postWPP  124 adult male 01day    75 adult male 05day    76 adult male 30day    75 adult female 01day  (168) adult female 05day  (217) adult female 30day  (222) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    376 embryo 02-04hr    383 embryo 04-06hr    96 embryo 06-08hr    88 embryo 08-10hr    113 embryo 10-12hr    120 embryo 12-14hr    61 embryo 14-16hr    64 embryo 16-18hr    43 embryo 18-20hr    28 embryo 20-22hr    29 embryo 22-24hr    29 larva L1    52 larva L2    124 larva L3 12hr old    98 larva L3 puffstage 1-2    141 larva L3 puffstage 3-6    226 larva L3 puffstage 7-9    313 white prepupae new    275 white prepupae 12hr    115 white prepupae 24hr    123 pupae 2d postWPP    76 pupae 3d postWPP    59 pupae 4d postWPP    124 adult male 01day    75 adult male 05day    76 adult male 30day    75 adult female 01day    168 adult female 05day    217 adult female 30day    222 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    223 Schneider line 2 Sg4    310 embryonic 1182-4H    123 embryonic GM2    168 embryonic Kc167    248 embryonic S1    149 embryonic S3    153 leg disc CME L1    193 wing disc CME-W2    201 wing disc ML-DmD8    195 wing disc ML-DmD9    151 wing disc ML-DmD16-c3    257 wing disc ML-DmD21    298 wing disc ML-DmD32    154 haltere disc ML-DmD17-c3    136 eye-antennal disc ML-DmD11    146 antennal disc ML-DmD20-c5    212 mixed discs ML-DmD4-c1    252 CNS ML-DmBG1-c1    227 CNS ML-DmBG2-c2    268 tumorous blood cells mbn2    147 ovary fGS/OSS    85 ovary OSC    95 ovary OSS    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (223) Schneider line 2 Sg4  (310) embryonic 1182-4H  (123) embryonic GM2  (168) embryonic Kc167  (248) embryonic S1  (149) embryonic S3  (153) leg disc CME L1  (193) wing disc CME-W2  (201) wing disc ML-DmD8  (195) wing disc ML-DmD9  (151) wing disc ML-DmD16-c3  (257) wing disc ML-DmD21  (298) wing disc ML-DmD32  (154) haltere disc ML-DmD17-c3  (136) eye-antennal disc ML-DmD11  (146) antennal disc ML-DmD20-c5  (212) mixed discs ML-DmD4-c1  (252) CNS ML-DmBG1-c1  (227) CNS ML-DmBG2-c2  (268) tumorous blood cells mbn2  (147) ovary fGS/OSS  (85) ovary OSC  (95) ovary OSS  (27) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (223) Schneider line 2 Sg4  (310) embryonic 1182-4H  (123) embryonic GM2  (168) embryonic Kc167  (248) embryonic S1  (149) embryonic S3  (153) leg disc CME L1  (193) wing disc CME-W2  (201) wing disc ML-DmD8  (195) wing disc ML-DmD9  (151) wing disc ML-DmD16-c3  (257) wing disc ML-DmD21  (298) wing disc ML-DmD32  (154) haltere disc ML-DmD17-c3  (136) eye-antennal disc ML-DmD11  (146) antennal disc ML-DmD20-c5  (212) mixed discs ML-DmD4-c1  (252) CNS ML-DmBG1-c1  (227) CNS ML-DmBG2-c2  (268) tumorous blood cells mbn2  (147) ovary fGS/OSS    85 ovary OSC    95 ovary OSS    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    223 Schneider line 2 Sg4    310 embryonic 1182-4H    123 embryonic GM2    168 embryonic Kc167    248 embryonic S1    149 embryonic S3    153 leg disc CME L1    193 wing disc CME-W2    201 wing disc ML-DmD8    195 wing disc ML-DmD9    151 wing disc ML-DmD16-c3    257 wing disc ML-DmD21    298 wing disc ML-DmD32    154 haltere disc ML-DmD17-c3    136 eye-antennal disc ML-DmD11    146 antennal disc ML-DmD20-c5    212 mixed discs ML-DmD4-c1    252 CNS ML-DmBG1-c1    227 CNS ML-DmBG2-c2    268 tumorous blood cells mbn2    147 ovary fGS/OSS    85 ovary OSC    95 ovary OSS    27 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    223 Schneider line 2 Sg4    310 embryonic 1182-4H    123 embryonic GM2    168 embryonic Kc167    248 embryonic S1    149 embryonic S3    153 leg disc CME L1    193 wing disc CME-W2    201 wing disc ML-DmD8    195 wing disc ML-DmD9    151 wing disc ML-DmD16-c3    257 wing disc ML-DmD21    298 wing disc ML-DmD32    154 haltere disc ML-DmD17-c3    136 eye-antennal disc ML-DmD11    146 antennal disc ML-DmD20-c5    212 mixed discs ML-DmD4-c1    252 CNS ML-DmBG1-c1    227 CNS ML-DmBG2-c2    268 tumorous blood cells mbn2    147 ovary fGS/OSS    85 ovary OSC    95 ovary OSS    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (223) Schneider line 2 Sg4  (310) embryonic 1182-4H  (123) embryonic GM2  (168) embryonic Kc167  (248) embryonic S1  (149) embryonic S3  (153) leg disc CME L1  (193) wing disc CME-W2  (201) wing disc ML-DmD8  (195) wing disc ML-DmD9  (151) wing disc ML-DmD16-c3  (257) wing disc ML-DmD21  (298) wing disc ML-DmD32  (154) haltere disc ML-DmD17-c3  (136) eye-antennal disc ML-DmD11  (146) antennal disc ML-DmD20-c5  (212) mixed discs ML-DmD4-c1  (252) CNS ML-DmBG1-c1  (227) CNS ML-DmBG2-c2  (268) tumorous blood cells mbn2  (147) ovary fGS/OSS  (85) ovary OSC  (95) ovary OSS  27 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (223) Schneider line 2 Sg4  (310) embryonic 1182-4H  123 embryonic GM2  (168) embryonic Kc167  (248) embryonic S1  (149) embryonic S3  (153) leg disc CME L1  (193) wing disc CME-W2  (201) wing disc ML-DmD8  (195) wing disc ML-DmD9  (151) wing disc ML-DmD16-c3  (257) wing disc ML-DmD21  (298) wing disc ML-DmD32  (154) haltere disc ML-DmD17-c3  136 eye-antennal disc ML-DmD11  (146) antennal disc ML-DmD20-c5  (212) mixed discs ML-DmD4-c1  (252) CNS ML-DmBG1-c1  (227) CNS ML-DmBG2-c2  (268) tumorous blood cells mbn2  (147) ovary fGS/OSS    85 ovary OSC    95 ovary OSS    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    223 Schneider line 2 Sg4    310 embryonic 1182-4H    123 embryonic GM2    168 embryonic Kc167    248 embryonic S1    149 embryonic S3    153 leg disc CME L1    193 wing disc CME-W2    201 wing disc ML-DmD8    195 wing disc ML-DmD9    151 wing disc ML-DmD16-c3    257 wing disc ML-DmD21    298 wing disc ML-DmD32    154 haltere disc ML-DmD17-c3    136 eye-antennal disc ML-DmD11    146 antennal disc ML-DmD20-c5    212 mixed discs ML-DmD4-c1    252 CNS ML-DmBG1-c1    227 CNS ML-DmBG2-c2    268 tumorous blood cells mbn2    147 ovary fGS/OSS    85 ovary OSC    95 ovary OSS    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    53 cold shock, 4-day adult    44 heat shock, 4-day adult    115 Cadmium 50 mM 6 hrs, larvae L3    117 Cadmium 50 mM 12 hrs, larvae L3    153 Cadmium 50 mM 48 hrs, 4-day adult    97 Cadmium 100 mM 48 hrs, 4-day adult    109 Copper 0.5 mM 12 hrs, larvae L3    88 Copper 15 mM 48 hrs, 4-day adult    108 Zinc 5 mM 12 hrs, larvae L3    54 Zinc 4.5 mM 48 hrs, 4-day adult    53 Ethanol 2.5% 3 hrs, larvae L3    124 Ethanol 5% 3 hrs, larvae L3    91 Ethanol 10% 3 hrs, larvae L3    81 Caffeine 1.5 mg/ml 4 hrs, larvae L3    75 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    91 Caffeine 25 mg/ml 48 hrs, 4-day adult    54 Paraquat 5 mM 48 hrs, 4-day adult    96 Paraquat 10 mM 48 hrs, 4-day adult    135 Rotenone 2 μg 12 hrs, larvae L3    97 Rotenone 8 μg 12 hrs, larvae L3    67 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (53) cold shock, 4-day adult  (44) heat shock, 4-day adult  (115) Cadmium 50 mM 6 hrs, larvae L3  (117) Cadmium 50 mM 12 hrs, larvae L3  (153) Cadmium 50 mM 48 hrs, 4-day adult  (97) Cadmium 100 mM 48 hrs, 4-day adult  (109) Copper 0.5 mM 12 hrs, larvae L3  (88) Copper 15 mM 48 hrs, 4-day adult  (108) Zinc 5 mM 12 hrs, larvae L3  (54) Zinc 4.5 mM 48 hrs, 4-day adult  (53) Ethanol 2.5% 3 hrs, larvae L3  (124) Ethanol 5% 3 hrs, larvae L3  (91) Ethanol 10% 3 hrs, larvae L3  (81) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (75) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (91) Caffeine 25 mg/ml 48 hrs, 4-day adult  (54) Paraquat 5 mM 48 hrs, 4-day adult  (96) Paraquat 10 mM 48 hrs, 4-day adult  (135) Rotenone 2 μg 12 hrs, larvae L3  (97) Rotenone 8 μg 12 hrs, larvae L3  (67) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    53 cold shock, 4-day adult    44 heat shock, 4-day adult  (115) Cadmium 50 mM 6 hrs, larvae L3  (117) Cadmium 50 mM 12 hrs, larvae L3  (153) Cadmium 50 mM 48 hrs, 4-day adult    97 Cadmium 100 mM 48 hrs, 4-day adult  (109) Copper 0.5 mM 12 hrs, larvae L3    88 Copper 15 mM 48 hrs, 4-day adult  (108) Zinc 5 mM 12 hrs, larvae L3    54 Zinc 4.5 mM 48 hrs, 4-day adult    53 Ethanol 2.5% 3 hrs, larvae L3  (124) Ethanol 5% 3 hrs, larvae L3    91 Ethanol 10% 3 hrs, larvae L3    81 Caffeine 1.5 mg/ml 4 hrs, larvae L3    75 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    91 Caffeine 25 mg/ml 48 hrs, 4-day adult    54 Paraquat 5 mM 48 hrs, 4-day adult    96 Paraquat 10 mM 48 hrs, 4-day adult  (135) Rotenone 2 μg 12 hrs, larvae L3    97 Rotenone 8 μg 12 hrs, larvae L3    67 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    53 cold shock, 4-day adult    44 heat shock, 4-day adult    115 Cadmium 50 mM 6 hrs, larvae L3    117 Cadmium 50 mM 12 hrs, larvae L3    153 Cadmium 50 mM 48 hrs, 4-day adult    97 Cadmium 100 mM 48 hrs, 4-day adult    109 Copper 0.5 mM 12 hrs, larvae L3    88 Copper 15 mM 48 hrs, 4-day adult    108 Zinc 5 mM 12 hrs, larvae L3    54 Zinc 4.5 mM 48 hrs, 4-day adult    53 Ethanol 2.5% 3 hrs, larvae L3    124 Ethanol 5% 3 hrs, larvae L3    91 Ethanol 10% 3 hrs, larvae L3    81 Caffeine 1.5 mg/ml 4 hrs, larvae L3    75 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    91 Caffeine 25 mg/ml 48 hrs, 4-day adult    54 Paraquat 5 mM 48 hrs, 4-day adult    96 Paraquat 10 mM 48 hrs, 4-day adult    135 Rotenone 2 μg 12 hrs, larvae L3    97 Rotenone 8 μg 12 hrs, larvae L3    67 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    53 cold shock, 4-day adult    44 heat shock, 4-day adult    115 Cadmium 50 mM 6 hrs, larvae L3    117 Cadmium 50 mM 12 hrs, larvae L3    153 Cadmium 50 mM 48 hrs, 4-day adult    97 Cadmium 100 mM 48 hrs, 4-day adult    109 Copper 0.5 mM 12 hrs, larvae L3    88 Copper 15 mM 48 hrs, 4-day adult    108 Zinc 5 mM 12 hrs, larvae L3    54 Zinc 4.5 mM 48 hrs, 4-day adult    53 Ethanol 2.5% 3 hrs, larvae L3    124 Ethanol 5% 3 hrs, larvae L3    91 Ethanol 10% 3 hrs, larvae L3    81 Caffeine 1.5 mg/ml 4 hrs, larvae L3    75 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    91 Caffeine 25 mg/ml 48 hrs, 4-day adult    54 Paraquat 5 mM 48 hrs, 4-day adult    96 Paraquat 10 mM 48 hrs, 4-day adult    135 Rotenone 2 μg 12 hrs, larvae L3    97 Rotenone 8 μg 12 hrs, larvae L3    67 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (53) cold shock, 4-day adult  (44) heat shock, 4-day adult  (115) Cadmium 50 mM 6 hrs, larvae L3  (117) Cadmium 50 mM 12 hrs, larvae L3  (153) Cadmium 50 mM 48 hrs, 4-day adult  (97) Cadmium 100 mM 48 hrs, 4-day adult  (109) Copper 0.5 mM 12 hrs, larvae L3  (88) Copper 15 mM 48 hrs, 4-day adult  (108) Zinc 5 mM 12 hrs, larvae L3  (54) Zinc 4.5 mM 48 hrs, 4-day adult  (53) Ethanol 2.5% 3 hrs, larvae L3  (124) Ethanol 5% 3 hrs, larvae L3  (91) Ethanol 10% 3 hrs, larvae L3  (81) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (75) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (91) Caffeine 25 mg/ml 48 hrs, 4-day adult  (54) Paraquat 5 mM 48 hrs, 4-day adult  (96) Paraquat 10 mM 48 hrs, 4-day adult  (135) Rotenone 2 μg 12 hrs, larvae L3  (97) Rotenone 8 μg 12 hrs, larvae L3  (67) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    53 cold shock, 4-day adult    44 heat shock, 4-day adult  115 Cadmium 50 mM 6 hrs, larvae L3  117 Cadmium 50 mM 12 hrs, larvae L3  (153) Cadmium 50 mM 48 hrs, 4-day adult    97 Cadmium 100 mM 48 hrs, 4-day adult  109 Copper 0.5 mM 12 hrs, larvae L3    88 Copper 15 mM 48 hrs, 4-day adult  108 Zinc 5 mM 12 hrs, larvae L3    54 Zinc 4.5 mM 48 hrs, 4-day adult    53 Ethanol 2.5% 3 hrs, larvae L3  124 Ethanol 5% 3 hrs, larvae L3    91 Ethanol 10% 3 hrs, larvae L3    81 Caffeine 1.5 mg/ml 4 hrs, larvae L3    75 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    91 Caffeine 25 mg/ml 48 hrs, 4-day adult    54 Paraquat 5 mM 48 hrs, 4-day adult    96 Paraquat 10 mM 48 hrs, 4-day adult  135 Rotenone 2 μg 12 hrs, larvae L3    97 Rotenone 8 μg 12 hrs, larvae L3    67 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    53 cold shock, 4-day adult    44 heat shock, 4-day adult    115 Cadmium 50 mM 6 hrs, larvae L3    117 Cadmium 50 mM 12 hrs, larvae L3    153 Cadmium 50 mM 48 hrs, 4-day adult    97 Cadmium 100 mM 48 hrs, 4-day adult    109 Copper 0.5 mM 12 hrs, larvae L3    88 Copper 15 mM 48 hrs, 4-day adult    108 Zinc 5 mM 12 hrs, larvae L3    54 Zinc 4.5 mM 48 hrs, 4-day adult    53 Ethanol 2.5% 3 hrs, larvae L3    124 Ethanol 5% 3 hrs, larvae L3    91 Ethanol 10% 3 hrs, larvae L3    81 Caffeine 1.5 mg/ml 4 hrs, larvae L3    75 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    91 Caffeine 25 mg/ml 48 hrs, 4-day adult    54 Paraquat 5 mM 48 hrs, 4-day adult    96 Paraquat 10 mM 48 hrs, 4-day adult    135 Rotenone 2 μg 12 hrs, larvae L3    97 Rotenone 8 μg 12 hrs, larvae L3    67 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_02 mE1_20_mRNA_expression_cluster_10
External Data & Images
Linkouts	BDGP expression data • RE28175 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004066 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3422-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Prosα4 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 Prosα4GD10962 Prosα4GD16562 Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of Prosα4 Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Prosα4 Class Mutagen Stocks Known lesion Prosα4GD10962 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Prosα4GD16562 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Prosα4GL00341 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Prosα4KK108682 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Prosα4NIG.3422R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 10 unique terms )
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
response to DNA damage stimulus inferred from mutant phenotype (Ravi et al., 2009)
Cellular Component
CV term Evidence References
microtubule associated complex inferred from direct assay (Hughes et al., 2008) proteasome core complex inferred from direct assay (Sumegi et al., 2003)
Terms Based on Predictions or Assertions ( 8 terms )
Molecular Function
CV term Evidence References
endopeptidase activity inferred from sequence or structural similarity with EMBL:AF019662 (FlyBase, 1992-) non-traceable author statement (Swiss-Prot Project Members, 1991.8.1) contributes_to endopeptidase activity inferred by curator from GO:0005839 (Sumegi et al., 2003) threonine-type endopeptidase activity inferred from electronic annotation with InterPro:IPR001353, InterPro:IPR023332 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
proteasomal ubiquitin-dependent protein catabolic process inferred by curator from GO:0005839 (Sumegi et al., 2003) proteolysis non-traceable author statement (Swiss-Prot Project Members, 1991.8.1) ubiquitin-dependent protein catabolic process inferred from electronic annotation with InterPro:IPR000426 (FlyBase Curators et al., 2004-) non-traceable author statement (Swiss-Prot Project Members, 1991.8.1)
Cellular Component
CV term Evidence References
proteasome complex non-traceable author statement (Swiss-Prot Project Members, 1991.8.1) proteasome core complex inferred from sequence or structural similarity with EMBL:AF019662 (FlyBase, 1992-) proteasome core complex, alpha-subunit complex inferred from electronic annotation with InterPro:IPR000426 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Prosα4 - AnxB10 experimental knowledge based (Guruharsha et al., 2011) Prosα4 - Aos1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - Arp1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - Arp2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - Arpc1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - Arpc3A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - Art8 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - Atg14 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - Bx anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - CG10306 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - CG10413 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - CG10638 experimental knowledge based (Guruharsha et al., 2011) Prosα4 - CG11007 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - CG1105 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - CG11060 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - CG11191 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - CG11236 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - CG11534 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - CG11842 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - CG11885 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) Prosα4 - CG12321 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) Prosα4 - CG13295 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - CG13319 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Prosα4 - CG13385 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - CG14195 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - CG14507 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - CG14715 experimental knowledge based (Guruharsha et al., 2011) Prosα4 - CG14968 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - CG14969 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - CG15011 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - CG15717 experimental knowledge based (Guruharsha et al., 2011) Prosα4 - CG1598 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - CG17834 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - CG18335 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - CG2004 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - CG2010 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - CG2046 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) Prosα4 - CG30195 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - CG3038 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - CG3107 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - CG31917 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - CG32512 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - CG3526 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - CG3544 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - CG3795 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - CG3812 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) Prosα4 - CG3862 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - CG3887 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - CG42678 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - CG4390 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - CG4691 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - CG4766 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - CG4991 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - CG5196 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - CG5347 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - CG5577 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - CG6084 experimental knowledge based (Guruharsha et al., 2011) Prosα4 - CG6145 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - CG7049 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - CG7288 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - CG7609 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - CG7675 experimental knowledge based (Guruharsha et al., 2011) Prosα4 - CG7881 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - CG8117 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - CG8314 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - CG8525 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) Prosα4 - CG8891 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - CG9536 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - CG9686 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - Clc anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - Corp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - Cp1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - Crc experimental knowledge based (Guruharsha et al., 2011) Prosα4 - Cyp4g15 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - DNaseII anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - Ent2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - Fkbp13 experimental knowledge based (Guruharsha et al., 2011) Prosα4 - Fmo-2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - Gadd34 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - Gip anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - Gmd anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - Hsc70-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - Ime4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - Klc experimental knowledge based (Guruharsha et al., 2011) Prosα4 - Lmpt anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - M6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - Mctp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - Mip anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - NAA20 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - NimB1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - Npc2g anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - P32 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - PHGPx anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - Patsas anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - Pdi experimental knowledge based (Guruharsha et al., 2011) Prosα4 - Pomp anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Prosα4 - Prosα1 experimental knowledge based (Guruharsha et al., 2011) Prosα4 - Prosα2 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Prosα4 - Prosα3 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Prosα4 - Prosα5 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Prosα4 - Prosα6 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) Prosα4 - Prosα6T anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - Prosα7 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Prosα4 - Prosβ1 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Prosα4 - Prosβ2 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Prosα4 - Prosβ2R1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - Prosβ2R2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - Prosβ3 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Prosα4 - Prosβ4 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Prosα4 - Prosβ4R1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - Prosβ4R2 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) Prosα4 - Prosβ5 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Prosα4 - Prosβ6 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Prosα4 - Prosβ7 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) Prosα4 - Pvf1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - REG experimental knowledge based (Guruharsha et al., 2011) Prosα4 - RpS5a anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - Rpn1 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Prosα4 - Rpn11 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Prosα4 - Rpn13 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Prosα4 - Rpn2 experimental knowledge based (Guruharsha et al., 2011) Prosα4 - Rpn6 experimental knowledge based (Guruharsha et al., 2011) Prosα4 - Rpn7 experimental knowledge based (Guruharsha et al., 2011) Prosα4 - Rpn8 experimental knowledge based (Guruharsha et al., 2011) Prosα4 - Rpn9 experimental knowledge based (Guruharsha et al., 2011) Prosα4 - Rpt1 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Prosα4 - Rpt2 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Prosα4 - Rpt3 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) Prosα4 - Rpt4 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Prosα4 - Rpt5 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) Prosα4 - Rpt6 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) Prosα4 - Rsf1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - Sh3β experimental knowledge based (Guruharsha et al., 2011) Prosα4 - TER94 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - Tango1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - Task7 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - Tgt anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - Traf4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - Trap1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - Uch-L5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - Uvrag anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - Vap-33-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - Vha100-4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - aur anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - ave anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - awd experimental knowledge based (Guruharsha et al., 2011) Prosα4 - boly anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - cpb anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - dpr5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - fbp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - fzr2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - l(1)G0004 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - morgue anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - mts anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - ninaE anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - olf186-F anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - p53 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - ref(2)P experimental knowledge based (Guruharsha et al., 2011) Prosα4 - regucalcin experimental knowledge based (Guruharsha et al., 2011) Prosα4 - santa-maria anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - shf anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - sina anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - spi anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - tub anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prosα4 - zpg anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Prosα4 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 58925 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0004066 DroID - A comprehensive database of gene and protein interactions. • FBgn0004066 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32584
Orthologs
OrthoDB Orthologs (41) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG63JCR0 Dipteran inclusive ortholog search EOG64F6K4 Insect inclusive ortholog search EOG6VQ8KC Arthropod inclusive ortholog search EOG69KD6K Metazoa inclusive ortholog search EOG6N3CH7
Orthologs in Drosophila Species (EOG63JCR0)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Prosα4     Drosophila erecta   Dere\GG17945 Y   Drosophila yakuba   Dyak\GE17253 Y   Drosophila ananassae   Dana\GF19028 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA17441 Y   Drosophila persimilis   Dper\GL21346     Drosophila willistoni   Dwil\GK25669 Y   Drosophila virilis   Dvir\Pros28.1 Y   Drosophila mojavensis   Dmoj\GI11210 Y   Drosophila grimshawi   Dgri\GH12557 Y
Orthologs in non-Drosophila Dipterans (EOG64F6K4)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL005830 Y Anopheles gambiae Malaria mosquito  Agam\AGAP005423 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ007179 Y
Orthologs in non-Dipteran Insects (EOG6VQ8KC)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC410095 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG019935 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH22999 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO21864 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL19240 Y Linepithema humile Argentine ant  Lhum\LH23080 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB18486 Y Solenopsis invicta Red fire ant  Sinv\SINV10889 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI007113 Y Bombyx mori Silkmoth  Bmor\BGIBMGA003028 Y Pediculus humanus Human body louse  Phum\PHUM463820 Y Pediculus humanus Human body louse  Phum\PHUM463910 Y Tribolium castaneum Red flour beetle  Tcas\TC014574 Y
Orthologs in non-Insect Arthropods (EOG69KD6K)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_231056 Y Ixodes scapularis Deer tick  Isca\ISCW007139 Y
Orthologs in non-Arthropod Metazoa (EOG6N3CH7)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\pas-4 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_018047gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_002937gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_023191gn Y Danio rerio Zebrafish  Drer\psma8 Y Xenopus tropicalis Western clawed frog  Xtro\psma7 Y Gallus gallus Domestic chicken  Ggal\PSMA7 Y Mus musculus House mouse  Mmus\Psma7 Y Rattus norvegicus Norway rat  Rnor\Psma7 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000010272 Y Rattus norvegicus Norway rat  Rnor\LOC100363246 Y Homo sapiens Human  Hsap\PSMA7 Y Homo sapiens Human  Hsap\PSMA8 Y
Human Orthologs (2)
Gene OMIM HGNC Hsap\PSMA7     Hsap\PSMA8
AAA Orthologs (8) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila erecta Dere\GG17945 Drosophila yakuba Dyak\GE17253 Drosophila ananassae Dana\GF19028 Drosophila pseudoobscura pseudoobscura Dpse\GA17441 Drosophila willistoni Dwil\GK25669 Drosophila virilis Dvir\Pros28.1 Drosophila mojavensis Dmoj\GI11210 Drosophila grimshawi Dgri\GH12557
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	36063 y1 sc* v1; P{TRiP.GL00341}attP2
VDRC	v105712 P{KK108682}VIE-260B v26187 w1118; P{GD10962}v26187 v26188 w1118; P{GD10962}v26188 v48735 w1118; P{GD16562}v48735/TM3
Genomic Clones ( 2 )
	BACR06P10 BACR13G13 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 86 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE28175
Other clones	DPiM_RE28175
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GM24385 LD13672 RE49765 RE72819 SD17760 SD18641
Other clones	19406 64876 77621 99520 145924 146731 190301 192076 CK01.19B.F12 Dmel_neb_005159_0129_2846 Dmel_neb_006075_0134_1554 EK002008 EK018056 EK057503 EK132415 EK191351 EK211343 EK221852 EK249333 EK292356 EK294464 FGM224C02 LD33247 RC0-DP0012-150700-011-G12 RP003012724 RP003019121 RP003034548 RP003040764 RP003040970 RP003059662 RP003066778 RP003089959 RP003092842 RP003094976 RP003102509 RP003106856 RP003119301 RP003121797 RP003136805 RP003136864 RP003145018 RP003147683 RP003157791 RP003159843 RP003161694 RP003164367 RP003183788 RP003185780 RP003208480 RP003210684 RP003251565 RP003253248 RP003265788 RP003267155 RP003279143 RP003280819 RP003285213 RP003307665 RP003335491 RP003338594 RP003375938 RP003381359 RP003393927 RP003404766 RP003468530 RP003472835 RP003494373 RP003496686 RP003499511 RP003508547 RP003515476 RP003531070 RP003558831 RP003563737 RP003604862 RP003616526 RP003658974 RP003662233
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0004066 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32584
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Prosα4 Pros28.1 (FlyBase, 2009-)
Source for database merge of
Additional comments	The nomenclature of genes encoding subunits of the 26S proteasome of D. melanogaster have been standardized according to FBrf0215459. These symbols/names largely follow those used already in FlyBase, and largely mirror fly community usage. HOWEVER, note that at least one other nomenclature system exists that is followed by the HUGO Gene Nomenclature Committee (HGNC), for example, with the unfortunate result that several D. melanogaster genes have shared synonyms. (FlyBase, 2009-) The Pros28.1A gene may have been derived from the Pros28.1 gene by retroposition. (Dai et al., 2006) The Pros28.1A gene may be derived from the Pros28.1 gene by retroposition. (Betran et al., 2002)
Other Comments
	Pros28.1A and Pros28.1B proteasome subunit genes are isolated and characterised, genes exhibit spermatogenesis-specific expression patterns. (Yuan et al., 1996) The Pros28.1 gene has been cloned and sequenced, and its genomic organisation has been analysed. (Frentzel et al., 1992) Only divergence between Arabidopsis and Drosophila Pros28 gene is in the 20 C-terminal amino acids. (Genschik et al., 1992) A Pros28.1 cDNA has been cloned and sequenced. (Haass et al., 1990) The cellular distribution of the proteasome during embryogenesis has been investigated using an antibody that cross-reacts strongly with a number of the 28kD proteasome subunits. (Klein et al., 1990)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_080353 RefSeq (Proteins) • NP_525092 DDBJ / EMBL / GenBank • AAA62768 AAF48573 AAL48863 AAS86210 AAS86211 AAS86212 AAS86213 AAS86214 AAS86215 AAS86216 AY071241 AY542383 AY542384 AY542385 AY542386 AY542387 AY542388 AY542389 BI232157 CAA44174 M57712 X62286 Entrez Gene - A searchable database of RefSeq genes. • 32584 UniProtKB/Swiss-Prot • P22769
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Proteasome, alpha-subunit, N-terminal domain (IPR000426) Proteasome, subunit alpha/beta (IPR001353) Proteasome A-type subunit (IPR023332) MEROPS - An information resource for peptidases and the proteins that inhibit them • T01.974 BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • RE28175
Linkouts
	BioGRID - A database of protein and genetic interactions • 58925 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0004066 DroID - A comprehensive database of gene and protein interactions. • FBgn0004066 DRSC - Results from RNAi screens. • FBgn0004066 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004066 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3422-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0004066 FlyReactome - A curated knowledgebase of Drosophila melanogaster pathways • 98988 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32584 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32584 modMine - Data generated by the modENCODE project. • FBgn0004066
Synonyms & Secondary IDs ( 22 )
Reported As
Symbol Synonym	28.1Pros (Mack et al., 2006) 3422 (Ravi et al., 2009) a4 (Torgerson and Singh, 2003) Alpha-4 (Lundgren et al., 2005) CG3422 (Dai et al., 2006, Zhang et al., 2011, Barbash and Lorigan, 2007, Keleman et al., 2009.8.5, Ma et al., 2002, Hughes et al., 2008, Ni et al., 2011.7.19, Cammarato et al., 2011, Lundgren et al., 2005, Belote and Zhong, 2009) Pros28 (Genschik et al., 1992, ) pros28.1 (Maier et al., 2001) PROS-28.1 (Haass et al., 1990) Pros28.1 (Mikhaylova et al., 2008, Legube et al., 2006, Langille and Clark, 2007, Stuart et al., 2007, Hoopfer et al., 2008, Sorourian and Betrán, 2008, Barbash and Lorigan, 2007, Ma et al., 2002, Bai et al., 2007, Japanese National Institute of Genetics, 2012.5.21) PROSA-28.1 (Haass, 1991.2.7) PROS-Dm28.1 (Kloetzel, 1991.9.27, Frentzel et al., 1992) Pros-Dm28.1   Prosα4 (Ma et al., 2002, ) PSA4_DROME (Storm and Sonnhammer, 2003) unnamed (Klein et al., 1990) α4 (Torgerson and Singh, 2004, Belote and Zhong, 2009) α4_dm (Belote et al., 1998, Zaiss and Belote, 1997)
Name Synonym	20s proteasome (Speese et al., 2003) 20S proteasome (Bohm et al., 2000) Proteasome 28kD subunit 1 (Cammarato et al., 2011, ) Proteasome α4 subunit   α4 (Nickell et al., 2009) α-subunit of 20S proteasome (Fredriksson et al., 2012)
Secondary FlyBase IDs
References ( 64 )
Generate a list of	All references relating to this gene ( 64 )
List References by type	Research paper  ( 38 ) Supplementary material  ( 6 ) Review  ( 1 ) Personal communication to FlyBase  ( 6 ) Abstract  ( 4 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 2 ) Stock list  ( 1 ) Protein sequence record  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 3 )
	Díaz-Castillo and Ranz, 2012, Mol. Biol. Evol. 29(9): 2105--2108 Nuclear chromosome dynamics in the Drosophila male germ line contribute to the nonrandom genomic distribution of retrogenes. [FBrf0219274] Fredriksson et al., 2012, Aging Cell 11(4): 634--643 Effects of aging and reproduction on protein quality control in soma and gametes of Drosophila melanogaster. [FBrf0218923] Zhang et al., 2011, Bioinformatics 27(13): 1749--1753 A cautionary note for retrocopy identification: DNA-based duplication of intron-containing genes significantly contributes to the origination of single exon genes. [FBrf0216536] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...