Please see the JBrowse view of Dmel\Dhfr for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.47
0.8 (northern blot)
182 (aa); 27 (kD observed)
Monomer. Interacts with vg.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Dhfr using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Dhfr transcripts are detected in adult RNA.
JBrowse - Visual display of RNA-Seq signals
View Dmel\Dhfr in JBrowse3-58
3-58.6
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Stepwise increases in methotrexate (MTX) concentration over a 4-year period led to the selection of a highly drug-resistant cell line.
Dhfr has been cloned and sequenced.
Purified Dhfr from adult flies has some of the properties that are typical of vertebrate Dhfrs and others which are typical of prokaryotic Dhfrs.
Dhfr has been purified and physical characteristics determined in the adult fly.
