A Database of Drosophila Genes & Genomes

FB2012_01, released January 20th, 2012
 

Gene Dmel\cdc2

General Information
SymbolDmel\cdc2SpeciesD. melanogaster
Namecdc2Annotation symbolCG5363
Feature typeprotein_coding_geneFlyBase IDFBgn0004106
Gene Model StatusCurrent Stock availability 14 publicly available
Also Known AsCdk1, DmCdc2
Genomic Location
Chromosome (arm)2LRecombination map
Cytogenetic map31D11-31D11Sequence location2L:10,384,739..10,386,263 [-]

Genomic Maps

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Automatically generated summary

See sections below for more information
The gene cdc2 is referred to in FlyBase by the symbol Dmel\cdc2 (CG5363, FBgn0004106). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: cyclin-dependent protein kinase activity; protein binding. There is experimental evidence for 12 unique biological process terms, many of which group under: cell cycle; anatomical structure development; cellular process involved in reproduction; cell cycle process; cell division; multicellular organismal reproductive process; response to DNA damage stimulus; macromolecule modification; biological regulation; interphase of mitotic cell cycle. 33 alleles are reported. The phenotypes of these alleles are annotated with: organ system subdivision; adult segment; organ system; imaginal precursor; somatic cell; nervous system; organelle; blastoderm embryo; cytoplasmic part; ganglion mother cell GMC4-2a; somatic stem cell; egg; cell cycle; dorsal thoracic disc. It has one annotated transcript and one annotated polypeptide. Protein features are: Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; Serine/threonine-protein kinase, active site; Serine/threonine-protein kinase, catalytic domain; Serine/threonine-protein kinase-like domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: larval trachea, adult testis. Comments on Affy2 ProbeSet: ProbeSet 1631861_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of cdc2. Gene sequence location is 2L:10384739..10386263.

External Summaries
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Description
What does this section display?
This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).
What does this section not display?
This section does not currently display links that were removed or gene model changes.
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FB2012_01
Sequence features
FB2011_10
All updates Click here to see a list of all updates to this record from FB2010_08 and on.
hide Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
31D11-31D11  
Limits computationally determined from genome sequence between P{lacW}RnrLk06709 and P{lacW}KdelRk00311  
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
31E-31E  
(determined by in situ hybridisation)  
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
hide Gene Model & Products
Please see the GBrowse view of Dmel\cdc2 for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
detailed view FBtr0080005 FBtr0080006 FBtr0113034 FBtr0080051 FBtr0080007 FBtr0080008 FBpp0079596 FBpp0111947 FBpp0079641 FBpp0079597 FBti0124717_1 FBti0124717_2 FBti0058523 FBti0014279 FBti0041102 FBti0109778 FBti0047377 FBti0026309 FBti0017170
Comments on Gene Model
hide Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Associated CDS (aa)
FBtr0080051
  1083
  297
Additional Transcript Data & Comments
Reported size (kB)
1.1 (northern blot)
Comments
External Data
Crossreferences
hide Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
FBpp0079641  
34.4  
297  
6.87  
Additional Polypeptide Data & Comments
Reported size (kDa)
297 (aa); 34.4 (kD)
Comments
External Data
Linkouts
Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
hide Sequences Consistent with the Gene Model
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
 
 
 
 
 
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
hide Mapped Features
Mapped Features have been reorganized, please see this article for details.
Additional mapped features and mutations can be found on GBrowse or related reports.
Type
Symbol & Location
Additional Notes
References
hide External Data
Linkouts
Crossreferences
hide Expression Data
hideTranscript Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
cdc2 transcripts are most abundant in early embryos and adult females. Transcripts are abundant and homogeneously distributed in unfertilized eggs and in the syncytial embryo. They appear to be largely excluded from the newly formed cells at division cycle 14.
cdc2 expression correlates temporally and spatially with cell proliferation in embryos.
Marker for
Subcellular Localization
CV Term
Notes
hidePolypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
hide High-Throughput Expression Data
or
Untitled Document detailed view CG5096-RA CG5096-RB cdc2-RA mRpS7-RA
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.

modENCODE Temporal Expression Data for FBgn0004106


   Styles
Linear
Logarithmic
Heatmap
   Scales
max expr for FBgn0004106
Very low expression bin max
Moderate expression bin max
High expression bin max
Extremely high expression bin max

Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages.
[download data (TSV)]

Guide to modENCODE expression level colors
 
No expression (0 - 0)
 
Extremely low expression (1 - 10)
 
Very low expression (11 - 100)
 
Low expression (101 - 400)
 
Moderate expression (401 - 1400)
 
Moderately high expression (1401 - 4000)
 
High expression (4001 - 10000)
 
Very high expression (10001 - 100000)
 
Extremely high expression (100001 - 2000000)

Linear, scaled to maximum FBgn0004106 expression level
Developmental Stage   Expression Level
embryo 00-02hr
 
 9492
embryo 02-04hr
 
 15569
embryo 04-06hr
 
 16247
embryo 06-08hr
 
 11575
embryo 08-10hr
 
 9521
embryo 10-12hr
 
 4440
embryo 12-14hr
 
 4565
embryo 14-16hr
 
 1796
embryo 16-18hr
 
 1526
embryo 18-20hr
 
 685
embryo 20-22hr
 
 1013
embryo 22-24hr
 
 1698
larva L1
 
 431
larva L2
 
 546
larva L3 12hr old
 
 428
larva L3 puffstage 1-2
 
 1385
larva L3 puffstage 3-6
 
 1678
larva L3 puffstage 7-9
 
 2677
white prepupae new
 
 2405
white prepupae 12hr
 
 2959
white prepupae 24hr
 
 2719
pupae 2d postWPP
 
 1597
pupae 3d postWPP
 
 537
pupae 4d postWPP
 
 371
adult male 01day
 
 386
adult male 05day
 
 579
adult male 30day
 
 433
adult female 01day
 
 1657
adult female 05day
 
 5871
adult female 30day
 
 5087
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
Linear, scaled to Very low expression
Developmental Stage   Expression Level
embryo 00-02hr
 (9492)
embryo 02-04hr
 (15569)
embryo 04-06hr
 (16247)
embryo 06-08hr
 (11575)
embryo 08-10hr
 (9521)
embryo 10-12hr
 (4440)
embryo 12-14hr
 (4565)
embryo 14-16hr
 (1796)
embryo 16-18hr
 (1526)
embryo 18-20hr
 (685)
embryo 20-22hr
 (1013)
embryo 22-24hr
 (1698)
larva L1
 (431)
larva L2
 (546)
larva L3 12hr old
 (428)
larva L3 puffstage 1-2
 (1385)
larva L3 puffstage 3-6
 (1678)
larva L3 puffstage 7-9
 (2677)
white prepupae new
 (2405)
white prepupae 12hr
 (2959)
white prepupae 24hr
 (2719)
pupae 2d postWPP
 (1597)
pupae 3d postWPP
 (537)
pupae 4d postWPP
 (371)
adult male 01day
 (386)
adult male 05day
 (579)
adult male 30day
 (433)
adult female 01day
 (1657)
adult female 05day
 (5871)
adult female 30day
 (5087)
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
Linear, scaled to Moderate expression
Developmental Stage   Expression Level
embryo 00-02hr
 (9492)
embryo 02-04hr
 (15569)
embryo 04-06hr
 (16247)
embryo 06-08hr
 (11575)
embryo 08-10hr
 (9521)
embryo 10-12hr
 (4440)
embryo 12-14hr
 (4565)
embryo 14-16hr
 (1796)
embryo 16-18hr
 (1526)
embryo 18-20hr
 
 685
embryo 20-22hr
 
 1013
embryo 22-24hr
 (1698)
larva L1
 
 431
larva L2
 
 546
larva L3 12hr old
 
 428
larva L3 puffstage 1-2
 
 1385
larva L3 puffstage 3-6
 (1678)
larva L3 puffstage 7-9
 (2677)
white prepupae new
 (2405)
white prepupae 12hr
 (2959)
white prepupae 24hr
 (2719)
pupae 2d postWPP
 (1597)
pupae 3d postWPP
 
 537
pupae 4d postWPP
 
 371
adult male 01day
 
 386
adult male 05day
 
 579
adult male 30day
 
 433
adult female 01day
 (1657)
adult female 05day
 (5871)
adult female 30day
 (5087)
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
Linear, scaled to High expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 9492
embryo 02-04hr
 (15569)
embryo 04-06hr
 (16247)
embryo 06-08hr
 (11575)
embryo 08-10hr
 
 9521
embryo 10-12hr
 
 4440
embryo 12-14hr
 
 4565
embryo 14-16hr
 
 1796
embryo 16-18hr
 
 1526
embryo 18-20hr
 
 685
embryo 20-22hr
 
 1013
embryo 22-24hr
 
 1698
larva L1
 
 431
larva L2
 
 546
larva L3 12hr old
 
 428
larva L3 puffstage 1-2
 
 1385
larva L3 puffstage 3-6
 
 1678
larva L3 puffstage 7-9
 
 2677
white prepupae new
 
 2405
white prepupae 12hr
 
 2959
white prepupae 24hr
 
 2719
pupae 2d postWPP
 
 1597
pupae 3d postWPP
 
 537
pupae 4d postWPP
 
 371
adult male 01day
 
 386
adult male 05day
 
 579
adult male 30day
 
 433
adult female 01day
 
 1657
adult female 05day
 
 5871
adult female 30day
 
 5087
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
Linear, scaled to Extremely high expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 9492
embryo 02-04hr
 
 15569
embryo 04-06hr
 
 16247
embryo 06-08hr
 
 11575
embryo 08-10hr
 
 9521
embryo 10-12hr
 
 4440
embryo 12-14hr
 
 4565
embryo 14-16hr
 
 1796
embryo 16-18hr
 
 1526
embryo 18-20hr
 
 685
embryo 20-22hr
 
 1013
embryo 22-24hr
 
 1698
larva L1
 
 431
larva L2
 
 546
larva L3 12hr old
 
 428
larva L3 puffstage 1-2
 
 1385
larva L3 puffstage 3-6
 
 1678
larva L3 puffstage 7-9
 
 2677
white prepupae new
 
 2405
white prepupae 12hr
 
 2959
white prepupae 24hr
 
 2719
pupae 2d postWPP
 
 1597
pupae 3d postWPP
 
 537
pupae 4d postWPP
 
 371
adult male 01day
 
 386
adult male 05day
 
 579
adult male 30day
 
 433
adult female 01day
 
 1657
adult female 05day
 
 5871
adult female 30day
 
 5087
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
 Extremely high 
log, scaled to maximum FBgn0004106 expression level
Developmental Stage   Expression Level
embryo 00-02hr
 
 9492
embryo 02-04hr
 
 15569
embryo 04-06hr
 
 16247
embryo 06-08hr
 
 11575
embryo 08-10hr
 
 9521
embryo 10-12hr
 
 4440
embryo 12-14hr
 
 4565
embryo 14-16hr
 
 1796
embryo 16-18hr
 
 1526
embryo 18-20hr
 
 685
embryo 20-22hr
 
 1013
embryo 22-24hr
 
 1698
larva L1
 
 431
larva L2
 
 546
larva L3 12hr old
 
 428
larva L3 puffstage 1-2
 
 1385
larva L3 puffstage 3-6
 
 1678
larva L3 puffstage 7-9
 
 2677
white prepupae new
 
 2405
white prepupae 12hr
 
 2959
white prepupae 24hr
 
 2719
pupae 2d postWPP
 
 1597
pupae 3d postWPP
 
 537
pupae 4d postWPP
 
 371
adult male 01day
 
 386
adult male 05day
 
 579
adult male 30day
 
 433
adult female 01day
 
 1657
adult female 05day
 
 5871
adult female 30day
 
 5087
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
log, scaled to Very low expression
Developmental Stage   Expression Level
embryo 00-02hr
 (9492)
embryo 02-04hr
 (15569)
embryo 04-06hr
 (16247)
embryo 06-08hr
 (11575)
embryo 08-10hr
 (9521)
embryo 10-12hr
 (4440)
embryo 12-14hr
 (4565)
embryo 14-16hr
 (1796)
embryo 16-18hr
 (1526)
embryo 18-20hr
 (685)
embryo 20-22hr
 (1013)
embryo 22-24hr
 (1698)
larva L1
 (431)
larva L2
 (546)
larva L3 12hr old
 (428)
larva L3 puffstage 1-2
 (1385)
larva L3 puffstage 3-6
 (1678)
larva L3 puffstage 7-9
 (2677)
white prepupae new
 (2405)
white prepupae 12hr
 (2959)
white prepupae 24hr
 (2719)
pupae 2d postWPP
 (1597)
pupae 3d postWPP
 (537)
pupae 4d postWPP
 (371)
adult male 01day
 (386)
adult male 05day
 (579)
adult male 30day
 (433)
adult female 01day
 (1657)
adult female 05day
 (5871)
adult female 30day
 (5087)
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
log, scaled to Moderate expression
Developmental Stage   Expression Level
embryo 00-02hr
 (9492)
embryo 02-04hr
 (15569)
embryo 04-06hr
 (16247)
embryo 06-08hr
 (11575)
embryo 08-10hr
 (9521)
embryo 10-12hr
 (4440)
embryo 12-14hr
 (4565)
embryo 14-16hr
 1796
embryo 16-18hr
 1526
embryo 18-20hr
 
 685
embryo 20-22hr
 
 1013
embryo 22-24hr
 1698
larva L1
 
 431
larva L2
 
 546
larva L3 12hr old
 
 428
larva L3 puffstage 1-2
 
 1385
larva L3 puffstage 3-6
 1678
larva L3 puffstage 7-9
 (2677)
white prepupae new
 2405
white prepupae 12hr
 (2959)
white prepupae 24hr
 (2719)
pupae 2d postWPP
 1597
pupae 3d postWPP
 
 537
pupae 4d postWPP
 
 371
adult male 01day
 
 386
adult male 05day
 
 579
adult male 30day
 
 433
adult female 01day
 1657
adult female 05day
 (5871)
adult female 30day
 (5087)
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
log, scaled to High expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 9492
embryo 02-04hr
 15569
embryo 04-06hr
 16247
embryo 06-08hr
 11575
embryo 08-10hr
 
 9521
embryo 10-12hr
 
 4440
embryo 12-14hr
 
 4565
embryo 14-16hr
 
 1796
embryo 16-18hr
 
 1526
embryo 18-20hr
 
 685
embryo 20-22hr
 
 1013
embryo 22-24hr
 
 1698
larva L1
 
 431
larva L2
 
 546
larva L3 12hr old
 
 428
larva L3 puffstage 1-2
 
 1385
larva L3 puffstage 3-6
 
 1678
larva L3 puffstage 7-9
 
 2677
white prepupae new
 
 2405
white prepupae 12hr
 
 2959
white prepupae 24hr
 
 2719
pupae 2d postWPP
 
 1597
pupae 3d postWPP
 
 537
pupae 4d postWPP
 
 371
adult male 01day
 
 386
adult male 05day
 
 579
adult male 30day
 
 433
adult female 01day
 
 1657
adult female 05day
 
 5871
adult female 30day
 
 5087
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
log, scaled to Extremely high expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 9492
embryo 02-04hr
 
 15569
embryo 04-06hr
 
 16247
embryo 06-08hr
 
 11575
embryo 08-10hr
 
 9521
embryo 10-12hr
 
 4440
embryo 12-14hr
 
 4565
embryo 14-16hr
 
 1796
embryo 16-18hr
 
 1526
embryo 18-20hr
 
 685
embryo 20-22hr
 
 1013
embryo 22-24hr
 
 1698
larva L1
 
 431
larva L2
 
 546
larva L3 12hr old
 
 428
larva L3 puffstage 1-2
 
 1385
larva L3 puffstage 3-6
 
 1678
larva L3 puffstage 7-9
 
 2677
white prepupae new
 
 2405
white prepupae 12hr
 
 2959
white prepupae 24hr
 
 2719
pupae 2d postWPP
 
 1597
pupae 3d postWPP
 
 537
pupae 4d postWPP
 
 371
adult male 01day
 
 386
adult male 05day
 
 579
adult male 30day
 
 433
adult female 01day
 
 1657
adult female 05day
 
 5871
adult female 30day
 
 5087
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
 Extremely high 
Heatmap
Developmental Stage   Expression Level
embryo 00-02hr
 
 
embryo 02-04hr
 
 
embryo 04-06hr
 
 
embryo 06-08hr
 
 
embryo 08-10hr
 
 
embryo 10-12hr
 
 
embryo 12-14hr
 
 
embryo 14-16hr
 
 
embryo 16-18hr
 
 
embryo 18-20hr
 
 
embryo 20-22hr
 
 
embryo 22-24hr
 
 
larva L1
 
 
larva L2
 
 
larva L3 12hr old
 
 
larva L3 puffstage 1-2
 
 
larva L3 puffstage 3-6
 
 
larva L3 puffstage 7-9
 
 
white prepupae new
 
 
white prepupae 12hr
 
 
white prepupae 24hr
 
 
pupae 2d postWPP
 
 
pupae 3d postWPP
 
 
pupae 4d postWPP
 
 
adult male 01day
 
 
adult male 05day
 
 
adult male 30day
 
 
adult female 01day
 
 
adult female 05day
 
 
adult female 30day
 
 

FlyAtlas Anatomical Expression Data for FBgn0004106


   Styles
Linear
Logarithmic
Heatmap
Back-to-back
   Scales
max expr for FBgn0004106
Moderate expression bin max
High level expression bin max
Very high expression bin max

Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: larval trachea, adult testis.
[download data (TSV)]

Guide to FlyAtlas expression level colors
 
No expression (0 - 9.999)
 
Low expression (10 - 99.999)
 
Moderate expression (100 - 499.999)
 
High level expression (500 - 999.999)
 
Very high expression (1000 - 25000)

Linear, scaled to maximum FBgn0004106 expression level
Tissue   Expression Level
Larval Central Nervous System
 
 694.675
Larval Midgut
 
 44.9
Larval Hindgut
 
 56.1
Larval Malpighian Tubules
 
 24.2
Larval Fat Body
 
 86.3
Larval Salivary Gland
 
 26.4
Larval Trachea
 
 217.975
Larval Carcass
 
 96.75
Adult Head
 
 9.6
Adult Eye
 
 15.275
Adult Brain
 
 4.1
Adult Thoracic-Abdominal Ganglion no informative data
Adult Crop no informative data
Adult Midgut
 
 25.7
Adult Hindgut no informative data
Adult Malpighian Tubules no informative data
Adult Fat Body
 
 8.2
Adult Salivary Gland no informative data
Adult Heart
 
 3.275
Adult VirginFemale Spermatheca no informative data
Adult InseminatedFemale Spermatheca no informative data
Adult Ovary
 
 882.2
Adult Testis
 
 194.6
Adult Male Accessory Gland
 
 5.2
Adult Carcass no informative data
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
Linear, scaled to Moderate expression
Tissue   Expression Level
Larval Central Nervous System
 (694.675)
Larval Midgut
 
 44.9
Larval Hindgut
 
 56.1
Larval Malpighian Tubules
 
 24.2
Larval Fat Body
 
 86.3
Larval Salivary Gland
 
 26.4
Larval Trachea
 
 217.975
Larval Carcass
 
 96.75
Adult Head
 
 9.6
Adult Eye
 
 15.275
Adult Brain
 
 4.1
Adult Thoracic-Abdominal Ganglion no informative data
Adult Crop no informative data
Adult Midgut
 
 25.7
Adult Hindgut no informative data
Adult Malpighian Tubules no informative data
Adult Fat Body
 
 8.2
Adult Salivary Gland no informative data
Adult Heart
 
 3.275
Adult VirginFemale Spermatheca no informative data
Adult InseminatedFemale Spermatheca no informative data
Adult Ovary
 (882.2)
Adult Testis
 
 194.6
Adult Male Accessory Gland
 
 5.2
Adult Carcass no informative data
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
Linear, scaled to High level expression
Tissue   Expression Level
Larval Central Nervous System
 
 694.675
Larval Midgut
 
 44.9
Larval Hindgut
 
 56.1
Larval Malpighian Tubules
 
 24.2
Larval Fat Body
 
 86.3
Larval Salivary Gland
 
 26.4
Larval Trachea
 
 217.975
Larval Carcass
 
 96.75
Adult Head
 
 9.6
Adult Eye
 
 15.275
Adult Brain
 
 4.1
Adult Thoracic-Abdominal Ganglion no informative data
Adult Crop no informative data
Adult Midgut
 
 25.7
Adult Hindgut no informative data
Adult Malpighian Tubules no informative data
Adult Fat Body
 
 8.2
Adult Salivary Gland no informative data
Adult Heart
 
 3.275
Adult VirginFemale Spermatheca no informative data
Adult InseminatedFemale Spermatheca no informative data
Adult Ovary
 
 882.2
Adult Testis
 
 194.6
Adult Male Accessory Gland
 
 5.2
Adult Carcass no informative data
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
Linear, scaled to Very high expression
Tissue   Expression Level
Larval Central Nervous System
 
 694.675
Larval Midgut
 
 44.9
Larval Hindgut
 
 56.1
Larval Malpighian Tubules
 
 24.2
Larval Fat Body
 
 86.3
Larval Salivary Gland
 
 26.4
Larval Trachea
 
 217.975
Larval Carcass
 
 96.75
Adult Head
 
 9.6
Adult Eye
 
 15.275
Adult Brain
 
 4.1
Adult Thoracic-Abdominal Ganglion no informative data
Adult Crop no informative data
Adult Midgut
 
 25.7
Adult Hindgut no informative data
Adult Malpighian Tubules no informative data
Adult Fat Body
 
 8.2
Adult Salivary Gland no informative data
Adult Heart
 
 3.275
Adult VirginFemale Spermatheca no informative data
Adult InseminatedFemale Spermatheca no informative data
Adult Ovary
 
 882.2
Adult Testis
 
 194.6
Adult Male Accessory Gland
 
 5.2
Adult Carcass no informative data
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
log, scaled to maximum FBgn0004106 expression level
Tissue   Expression Level
Larval Central Nervous System
 
 694.675
Larval Midgut
 
 44.9
Larval Hindgut
 
 56.1
Larval Malpighian Tubules
 
 24.2
Larval Fat Body
 
 86.3
Larval Salivary Gland
 
 26.4
Larval Trachea
 
 217.975
Larval Carcass
 
 96.75
Adult Head
 
 9.6
Adult Eye
 
 15.275
Adult Brain
 
 4.1
Adult Thoracic-Abdominal Ganglion no informative data
Adult Crop no informative data
Adult Midgut
 
 25.7
Adult Hindgut no informative data
Adult Malpighian Tubules no informative data
Adult Fat Body
 
 8.2
Adult Salivary Gland no informative data
Adult Heart
 
 3.275
Adult VirginFemale Spermatheca no informative data
Adult InseminatedFemale Spermatheca no informative data
Adult Ovary
 
 882.2
Adult Testis
 
 194.6
Adult Male Accessory Gland
 
 5.2
Adult Carcass no informative data
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
log, scaled to Moderate expression
Tissue   Expression Level
Larval Central Nervous System
 694.675
Larval Midgut
 
 44.9
Larval Hindgut
 
 56.1
Larval Malpighian Tubules
 
 24.2
Larval Fat Body
 
 86.3
Larval Salivary Gland
 
 26.4
Larval Trachea
 
 217.975
Larval Carcass
 
 96.75
Adult Head
 
 9.6
Adult Eye
 
 15.275
Adult Brain
 
 4.1
Adult Thoracic-Abdominal Ganglion no informative data
Adult Crop no informative data
Adult Midgut
 
 25.7
Adult Hindgut no informative data
Adult Malpighian Tubules no informative data
Adult Fat Body
 
 8.2
Adult Salivary Gland no informative data
Adult Heart
 
 3.275
Adult VirginFemale Spermatheca no informative data
Adult InseminatedFemale Spermatheca no informative data
Adult Ovary
 (882.2)
Adult Testis
 
 194.6
Adult Male Accessory Gland
 
 5.2
Adult Carcass no informative data
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
log, scaled to High level expression
Tissue   Expression Level
Larval Central Nervous System
 
 694.675
Larval Midgut
 
 44.9
Larval Hindgut
 
 56.1
Larval Malpighian Tubules
 
 24.2
Larval Fat Body
 
 86.3
Larval Salivary Gland
 
 26.4
Larval Trachea
 
 217.975
Larval Carcass
 
 96.75
Adult Head
 
 9.6
Adult Eye
 
 15.275
Adult Brain
 
 4.1
Adult Thoracic-Abdominal Ganglion no informative data
Adult Crop no informative data
Adult Midgut
 
 25.7
Adult Hindgut no informative data
Adult Malpighian Tubules no informative data
Adult Fat Body
 
 8.2
Adult Salivary Gland no informative data
Adult Heart
 
 3.275
Adult VirginFemale Spermatheca no informative data
Adult InseminatedFemale Spermatheca no informative data
Adult Ovary
 
 882.2
Adult Testis
 
 194.6
Adult Male Accessory Gland
 
 5.2
Adult Carcass no informative data
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
log, scaled to Very high expression
Tissue   Expression Level
Larval Central Nervous System
 
 694.675
Larval Midgut
 
 44.9
Larval Hindgut
 
 56.1
Larval Malpighian Tubules
 
 24.2
Larval Fat Body
 
 86.3
Larval Salivary Gland
 
 26.4
Larval Trachea
 
 217.975
Larval Carcass
 
 96.75
Adult Head
 
 9.6
Adult Eye
 
 15.275
Adult Brain
 
 4.1
Adult Thoracic-Abdominal Ganglion no informative data
Adult Crop no informative data
Adult Midgut
 
 25.7
Adult Hindgut no informative data
Adult Malpighian Tubules no informative data
Adult Fat Body
 
 8.2
Adult Salivary Gland no informative data
Adult Heart
 
 3.275
Adult VirginFemale Spermatheca no informative data
Adult InseminatedFemale Spermatheca no informative data
Adult Ovary
 
 882.2
Adult Testis
 
 194.6
Adult Male Accessory Gland
 
 5.2
Adult Carcass no informative data
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
Heatmap
Tissue   Expression Level
Larval Central Nervous System
 
 
Larval Midgut
 
 
Larval Hindgut
 
 
Larval Malpighian Tubules
 
 
Larval Fat Body
 
 
Larval Salivary Gland
 
 
Larval Trachea
 
 
Larval Carcass
 
 
Adult Head
 
 
Adult Eye
 
 
Adult Brain
 
 
Adult Thoracic-Abdominal Ganglion no informative data
Adult Crop no informative data
Adult Midgut
 
 
Adult Hindgut no informative data
Adult Malpighian Tubules no informative data
Adult Fat Body
 
 
Adult Salivary Gland no informative data
Adult Heart
 
 
Adult VirginFemale Spermatheca no informative data
Adult InseminatedFemale Spermatheca no informative data
Adult Ovary
 
 
Adult Testis
 
 
Adult Male Accessory Gland
 
 
Adult Carcass no informative data

FlyAtlas Organ/Tissue Expression, larval vs. adult
Larval Expression Level Tissue Adult Expression Level
 
NA 
Head
 
 9.6
 
NA 
Eye
 
 15.275
 
NA 
Brain
 
 4.1
 
694.675 
Central Nervous System
 
 NA
 
NA 
Thoracic-Abdominal Ganglion
 
 no informative data
 
NA 
Crop
 
 no informative data
 
44.9 
Midgut
 
 25.7
 
56.1 
Hindgut
 
 no informative data
 
24.2 
Malpighian Tubules
 
 no informative data
 
86.3 
Fat Body
 
 8.2
 
26.4 
Salivary Gland
 
 no informative data
 
NA 
Heart
 
 3.275
 
217.975 
Trachea
 
 NA
 
NA 
VirginFemale Spermatheca
 
 no informative data
 
NA 
InseminatedFemale Spermatheca
 
 no informative data
 
NA 
Ovary
 
 882.2
 
NA 
Testis
 
 194.6
 
NA 
Male Accessory Gland
 
 5.2
 
96.75 
Carcass
 
 no informative data

modENCODE Temporal Expression Data (Graveley et al., 2011)
FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
hide Expression Clusters
A cluster of genes with similar mRNA expression dynamics across development.
hide External Data & Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyExpress - Embryonic expression images (BDGP data)
hide Alleles & Phenotypes
hide Summary of Allele Phenotypes
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
embryonic neuroblast & spindle
ganglion mother cell GMC4-2a & spindle
histoblast & nucleus | conditional ts (with cdc2B47)
histoblast & nucleus | conditional ts (with cdc2E1-24)
hide Classical Alleles ( 15 )
For All Classical Alleles Show

Allele of cdc2ClassMutagenStocksKnown lesion
cdc2c034952 --
cdc2B47loss of function allele, amorphic allele - genetic evidence1 Yes
cdc2E1-23amorphic allele - genetic evidence1 Yes
cdc2E1-24hypomorphic allele - genetic evidence1 Yes
cdc2GT-0002941 --
cdc2D57amorphic allele - genetic evidence0 Yes
cdc2E1-9amorphic allele - genetic evidence0 Yes
cdc2E10amorphic allele - genetic evidence0 Yes
cdc2216Ahypomorphic allele - genetic evidence0 Yes
cdc2216Phypomorphic allele - genetic evidence0 Yes
cdc22
0 --
cdc23
0 --
cdc2E1-4hypomorphic allele - genetic evidence0 Yes
cdc2E51Q
0 Yes
cdc2unspecified
0 --
hide Alleles Carried on Transgenic Constructs ( 18 )
For All Alleles Carried on Transgenic Constructs Show

Allele of cdc2ClassMutagenStocksKnown lesion
cdc2GD107282 Yes
cdc2Scer\UAS.T:Hsap\MYC2 Yes
cdc2GL002621 Yes
cdc2HMS015311 Yes
cdc2JF030041 Yes
cdc2KK1027091 Yes
cdc2+t5.80 Yes
cdc2A171T0 Yes
cdc2AF.hs0 Yes
cdc2E51Q.Scer\UAS0 Yes
cdc2G177E0 Yes
cdc2G43E0 Yes
cdc2hs.PS0 Yes
cdc2K33R.T161A.Scer\UAS0 Yes
cdc2P131S0 Yes
cdc2Scer\UAS.cHa0 Yes
cdc2Scer\UAS.cWa0 Yes
cdc2T161A.Scer\UAS0 Yes
hide Aneuploid Aberrations
Disrupted in
Not disrupted in
hide Transgenic Constructs & Insertions
Transgenic Constructs
Type of construct
Name
Expression data
heat-shock construct
characterization construct
Insertions
Type of insertions
Name
Expression data
hide Gene Ontology: Function, Process & Cellular Component ( 23 unique terms )
hide Terms Based on Experimental Evidence ( 15 terms )
Molecular Function
CV term
References
inferred from physical interaction with CycB3
(assigned by UniProtKB)
Biological Process
CV term
References
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from genetic interaction with Saccharomyces CDC28
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from direct assay
inferred from mutant phenotype
inferred from mutant phenotype
Cellular Component
CV term
References
hide Terms Based on Predictions or Assertions ( 11 terms )
Molecular Function
CV term
References
Biological Process
CV term
References
traceable author statement
traceable author statement
non-traceable author statement
traceable author statement
Cellular Component
CV term
References
hide Sequence Ontology: Class of Gene
hide Interactions & Pathways
hide Summary of Physical Interactions
Protein-protein
Interacting group
Assay
References
hide Summary of Genetic Interactions
Interacts with
Please look at the allele data for full details of the genetic interactions
cdc2 allele
Gene
References
hide External Data
Linkouts
BioGRID - A database of protein and genetic interactions
DPiM - DPiM, Drosophila Protein interaction Map
DroID - A comprehensive database of gene and protein interactions.
InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.
hide Orthologs
Genome-wide drosophilid orthologs
Curated drosophilid orthologs
Linkouts
InParanoid A subset of ortholog calls from InParanoid.
OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs.
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hide Stocks Listed in FlyBase ( 14 )
Bloomington
Harvard
VDRC
hide Genomic Clones ( 2 )
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
hide cDNA Clones ( 46 )
Please Note
This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
hide RNAi & Array Information
Linkouts
DRSC - Results from RNAi screens.
GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
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hide Relationship to Other Genes
Source for database identity of
Source for identity of: cdc2 CG5363
Source for database merge of
Additional comments
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Treatment of S2-derived S2-NP cells with dsRNA made from templates generated with primers directed against cdc2 results in a decrease in Stat92E tyrosine phosphorylation.
Myt1 inhibitory phosphorylation of cdc2 is required for regulating multiple aspects of cell cycle behaviour during spermatogenesis.
When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, an increase in the proportion of G2/M phase cells, a decrease in cell size, a decrease in cytokinetic index, a decrease in the ratio of cells in prometaphase and metaphase versus the total number of mitotic cells and chromosome abnormalities are seen.
RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.
RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in Kc167 and S2R+ cells: cell size is increased, microtubules are uniform or disorganised, cell shape is irregular, and cell number is decreased indicative of a failure in cell cycle progression through G1 to S and G2 to M stages.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
By attenuating cdc2 function without blocking mitosis, normally asymmetric neural progenitor divisions become defective, failing to correctly localise asymmetric components during mitosis and/or to resolve distinct sibling fates.
Neural progenitor asymmetric divisions require cdc2.
polo protein kinase, in embryos, has a narrow peak of activity during late anaphase-telophase, separable from the peak of cdc2 activity.
A cdc2-dependent checkpoint acts to maintain diplody. In G2, esg is required to maintain a high level of G2/M cdk (a complex that includes the catalytic subunit encoded by cdc2 and a regulatory subunit G2 cyclin) that actively inhibits the entry into S phase.
cdc2 is required for both meiotic divisions during spermatogenesis. cdc2 function is activated by twe phosphatase.
Mutations in fzy result in metaphase arrest, neither CycA, CycB or CycB3 are degraded in this arrest. Inactivation of a temperature sensitive cdc2 in fzy metaphase arrest causes a reversion to interphase morphology. This reversion is not accompanied by completion of mitosis so there is no increase in anaphase cells or change in cell number or size.
The activity of cdc2 is highly sensitive to Cdc37 levels, suggesting that the two genes may act in a common pathway to regulate cell cycle control.
During development changing levels of cell cycle regulators alters the rate limiting step and the mechanism governing progress of the cell cycle. Three phases of developmental progression of cell cycle regulation have been defined. The first seven cycles run in the presence of constitutively active cdc2. Later during cycles 8-13 increasing mitotic destruction of cyclins drives oscillations in cdc2 activity, cyclin accumulation becomes the rate limiting step for mitosis. Degradation of maternally supplied stg causes tyrosine dephosphorylation of cdc2 to become rate limiting for mitosis beginning in cycle 14.
Yeast interaction mating has been used to characterise Cyclin-dependent kinase interactor proteins (the prey) in hunts with either cdc2 or cdc2c as baits.
Twelve (unnamed) recessive lethal alleles have been isolated during a cytogenetic analysis of chromosomal region 31.
Preliminary genetic and molecular analysis of mutations of cdc2.
In contrast to the polo gene product, for which kinase activity peaks cyclically at late anaphase/telophase, CycB-associated cdc2 histone H1 kinase activity is maximal upon entry into mitosis during the rapid syncytial mitoses.
cdc2 gene product is not essential for DNA replication during embryogenesis.
cdc2 function is essential for cell proliferation throughout development, though block occurs in G2 and no function in S phase could be identified. While the mitotic proliferation of imaginal cells was blocked in mutants, non-imaginal cells continue to grow and endoreplicate their DNA. cdc2c cannot compensate for lack of cdc2 function indicating the independence of their action.
Recombination mapping and intensive mapping studies of the Su(var)207 and Su(var)2-1216 chromosomes suggested a closely linked second site lethal. Genetic and molecular analysis of the second site lethal revealed it to be an allele of the cdc2 gene (Lehner, EMBO J. 9: 3573--3581, Jimenez, EMBO J. 9: 3565--3571).
Cross-species complementation tests reveal that a cdc2 cDNA clone will rescue S.cerevisiae deficient in cyclin gene functions.
The sequence and expression pattern of cdc2 has been determined.
Northern blot and in situ hybridization studies demonstrate that cdc2 and cdc2c are co-expressed during embryogenesis. cdc2 expression is correlated with cell proliferation.
Complements yeast temperature-sensitive cdc28 alleles.
 
hide External Crossreferences & Linkouts
Sequence Crossreferences
RefSeq (Transcripts)
RefSeq (Proteins)
Entrez Gene - A searchable database of RefSeq genes.
Other Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
Linkouts
BioGRID - A database of protein and genetic interactions
DPiM - DPiM, Drosophila Protein interaction Map
DroID - A comprehensive database of gene and protein interactions.
DRSC - Results from RNAi screens.
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans
GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
InParanoid A subset of ortholog calls from InParanoid.
Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.
modMine - Data generated by the modENCODE project.
OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs.
hide Synonyms & Secondary IDs ( 26 )
Reported As
Symbol Synonym
l(2)31Eh
 
Name Synonym
Cdc2 kinase
cyclin dependent kinase
cyclin-dependent kinase
cyclin-dependent kinase 1
Secondary FlyBase IDs
hide References ( 268 )
Generate a list of
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hide Recent research papers ( 10 )
Nakajima et al., 2011, Mol. Cell. Biol. 31(12): 2499--2512
Nonautonomous Apoptosis Is Triggered by Local Cell Cycle Progression during Epithelial Replacement in Drosophila. [FBrf0213728]
Baig et al., 2010, Genetics 184(3): 731--744
The chromatin-remodeling protein Osa interacts with CyclinE in Drosophila eye imaginal discs. [FBrf0210399]
Beam and Moberg, 2010, Fly 4(2): 104--116
The gang of four gene regulates growth and patterning of the developing Drosophila eye. [FBrf0211089]
Blanco et al., 2010, BMC Dev. Biol. 10: 94
Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812]
Li et al., 2010, PLoS Genet. 6(3): e1000876
Drosophila xpd regulates cdk7 localization, mitotic kinase activity, spindle dynamics, and chromosome segregation. [FBrf0210295]
Oliveira et al., 2010, Nat. Cell Biol. 12(2): 185--192
Cohesin cleavage and Cdk inhibition trigger formation of daughter nuclei. [FBrf0209876]
Papoulas et al., 2010, Development 137(24): 4201--4209
dFMRP and Caprin, translational regulators of synaptic plasticity, control the cell cycle at the Drosophila mid-blastula transition. [FBrf0212321]
Swaminathan and Pile, 2010, Mech. Dev. 127(1-2): 96--106
Regulation of cell proliferation and wing development by Drosophila SIN3 and String. [FBrf0209854]
Terriente-Félix et al., 2010, Genetics 185(2): 671--684
Identification of genes affecting wing patterning through a loss-of-function mutagenesis screen and characterization of med15 function during wing development. [FBrf0211230]
Zeng et al., 2010, J. Cell. Physiol. 224(3): 766--774
Tumor suppressors Sav/scrib and oncogene ras regulate stem-cell transformation in adult Drosophila malpighian tubules. [FBrf0211181]
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All reviews listed in FlyBase were published before 2010