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Gene Dmel\cdc2

General Information
Symbol	Dmel\cdc2	Species	D. melanogaster
Name	cdc2	Annotation symbol	CG5363
Feature type	protein_coding_gene	FlyBase ID	FBgn0004106
Gene Model Status	Current	Stock availability	14 publicly available
Also Known As	Cdk1, DmCdc2
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	31D11-31D11	Sequence location	2L:10,384,739..10,386,263 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene cdc2 is referred to in FlyBase by the symbol Dmel\cdc2 (CG5363, FBgn0004106). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: cyclin-dependent protein kinase activity; protein binding. There is experimental evidence for 12 unique biological process terms, many of which group under: cell cycle; anatomical structure development; cellular process involved in reproduction; cell cycle process; cell division; multicellular organismal reproductive process; response to DNA damage stimulus; macromolecule modification; biological regulation; interphase of mitotic cell cycle. 33 alleles are reported. The phenotypes of these alleles are annotated with: organ system subdivision; adult segment; organ system; imaginal precursor; somatic cell; nervous system; organelle; blastoderm embryo; cytoplasmic part; ganglion mother cell GMC4-2a; somatic stem cell; egg; cell cycle; dorsal thoracic disc. It has one annotated transcript and one annotated polypeptide. Protein features are: Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; Serine/threonine-protein kinase, active site; Serine/threonine-protein kinase, catalytic domain; Serine/threonine-protein kinase-like domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: larval trachea, adult testis. Comments on Affy2 ProbeSet: ProbeSet 1631861_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of cdc2. Gene sequence location is 2L:10384739..10386263.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	Sequence features BKN51124 BKN50710 BKN22805 HFA03504
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 31D11-31D11   Limits computationally determined from genome sequence between P{lacW}RnrLk06709 and P{lacW}KdelRk00311
Experimentally Determined Cytological Location
Cytogenetic map Notes References 31E-31E   (determined by in situ hybridisation)   (Jimenez et al., 1990)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\cdc2 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) cdc2-RA FBtr0080051  NM_057449   1083   297
Additional Transcript Data & Comments
Reported size (kB)	1.1 (northern blot) (Lehner and O'Farrell, 1990)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein cdc2-PA   FBpp0079641   34.4   297   6.87     NP_476797   AAF52932
Additional Polypeptide Data & Comments
Reported size (kDa)	297 (aa); 34.4 (kD) (Lehner and O'Farrell, 1990) 297 (aa) (Jimenez et al., 1990)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) Serine/threonine-protein kinase, catalytic domain (IPR002290) Serine/threonine-protein kinase, active site (IPR008271) Protein kinase-like domain (IPR011009) Protein kinase, ATP binding site (IPR017441) Serine/threonine-protein kinase-like domain (IPR017442)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141625   AA263877   AA391911   AA942463   AA950854   AA951202   AE014134 AAF52932   AC007451   AI519205   AW943439   AY061450 AAL28998   BG639151   BI163917   BI164112   BI168226   BI169617   BI172464   BI237327   BI239560   BI362889   BI366681   BI366895   BI369185   BI371169   BI371975   BI483569   BI486493   BI577575   BI579439   BI635198   CO178068   CO178261   CO178467   CO305709   CO308356   CO310542   EC051004   EC051355   EC051503   EC053984   EC054483   EC054877   EC055873   EC056444   EC077412   EC081093   EC202107   EC215029   EV582808   S66801   S66804   S66805   S66807   S66810   X57485 CAA40723   X57496 CAA40733
UniProtKB/Swiss-Prot	P23572
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference embryonic stage | early     (Lehner and O'Farrell, 1990) adult stage | female     (Jimenez et al., 1990) in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 3 -- 8     (Jimenez et al., 1990) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage   presumptive embryonic/larval central nervous system   (Lehner and O'Farrell, 1990)   (Jimenez et al., 1990)
Additional Descriptive Data
	cdc2 transcripts are most abundant in early embryos and adult females. Transcripts are abundant and homogeneously distributed in unfertilized eggs and in the syncytial embryo. They appear to be largely excluded from the newly formed cells at division cycle 14. (Jimenez et al., 1990) cdc2 expression correlates temporally and spatially with cell proliferation in embryos. (Lehner and O'Farrell, 1990)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0004106    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0004106 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0004106 expression level Developmental Stage   Expression Level embryo 00-02hr    9492 embryo 02-04hr    15569 embryo 04-06hr    16247 embryo 06-08hr    11575 embryo 08-10hr    9521 embryo 10-12hr    4440 embryo 12-14hr    4565 embryo 14-16hr    1796 embryo 16-18hr    1526 embryo 18-20hr    685 embryo 20-22hr    1013 embryo 22-24hr    1698 larva L1    431 larva L2    546 larva L3 12hr old    428 larva L3 puffstage 1-2    1385 larva L3 puffstage 3-6    1678 larva L3 puffstage 7-9    2677 white prepupae new    2405 white prepupae 12hr    2959 white prepupae 24hr    2719 pupae 2d postWPP    1597 pupae 3d postWPP    537 pupae 4d postWPP    371 adult male 01day    386 adult male 05day    579 adult male 30day    433 adult female 01day    1657 adult female 05day    5871 adult female 30day    5087 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (9492) embryo 02-04hr  (15569) embryo 04-06hr  (16247) embryo 06-08hr  (11575) embryo 08-10hr  (9521) embryo 10-12hr  (4440) embryo 12-14hr  (4565) embryo 14-16hr  (1796) embryo 16-18hr  (1526) embryo 18-20hr  (685) embryo 20-22hr  (1013) embryo 22-24hr  (1698) larva L1  (431) larva L2  (546) larva L3 12hr old  (428) larva L3 puffstage 1-2  (1385) larva L3 puffstage 3-6  (1678) larva L3 puffstage 7-9  (2677) white prepupae new  (2405) white prepupae 12hr  (2959) white prepupae 24hr  (2719) pupae 2d postWPP  (1597) pupae 3d postWPP  (537) pupae 4d postWPP  (371) adult male 01day  (386) adult male 05day  (579) adult male 30day  (433) adult female 01day  (1657) adult female 05day  (5871) adult female 30day  (5087) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (9492) embryo 02-04hr  (15569) embryo 04-06hr  (16247) embryo 06-08hr  (11575) embryo 08-10hr  (9521) embryo 10-12hr  (4440) embryo 12-14hr  (4565) embryo 14-16hr  (1796) embryo 16-18hr  (1526) embryo 18-20hr    685 embryo 20-22hr    1013 embryo 22-24hr  (1698) larva L1    431 larva L2    546 larva L3 12hr old    428 larva L3 puffstage 1-2    1385 larva L3 puffstage 3-6  (1678) larva L3 puffstage 7-9  (2677) white prepupae new  (2405) white prepupae 12hr  (2959) white prepupae 24hr  (2719) pupae 2d postWPP  (1597) pupae 3d postWPP    537 pupae 4d postWPP    371 adult male 01day    386 adult male 05day    579 adult male 30day    433 adult female 01day  (1657) adult female 05day  (5871) adult female 30day  (5087) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    9492 embryo 02-04hr  (15569) embryo 04-06hr  (16247) embryo 06-08hr  (11575) embryo 08-10hr    9521 embryo 10-12hr    4440 embryo 12-14hr    4565 embryo 14-16hr    1796 embryo 16-18hr    1526 embryo 18-20hr    685 embryo 20-22hr    1013 embryo 22-24hr    1698 larva L1    431 larva L2    546 larva L3 12hr old    428 larva L3 puffstage 1-2    1385 larva L3 puffstage 3-6    1678 larva L3 puffstage 7-9    2677 white prepupae new    2405 white prepupae 12hr    2959 white prepupae 24hr    2719 pupae 2d postWPP    1597 pupae 3d postWPP    537 pupae 4d postWPP    371 adult male 01day    386 adult male 05day    579 adult male 30day    433 adult female 01day    1657 adult female 05day    5871 adult female 30day    5087 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    9492 embryo 02-04hr    15569 embryo 04-06hr    16247 embryo 06-08hr    11575 embryo 08-10hr    9521 embryo 10-12hr    4440 embryo 12-14hr    4565 embryo 14-16hr    1796 embryo 16-18hr    1526 embryo 18-20hr    685 embryo 20-22hr    1013 embryo 22-24hr    1698 larva L1    431 larva L2    546 larva L3 12hr old    428 larva L3 puffstage 1-2    1385 larva L3 puffstage 3-6    1678 larva L3 puffstage 7-9    2677 white prepupae new    2405 white prepupae 12hr    2959 white prepupae 24hr    2719 pupae 2d postWPP    1597 pupae 3d postWPP    537 pupae 4d postWPP    371 adult male 01day    386 adult male 05day    579 adult male 30day    433 adult female 01day    1657 adult female 05day    5871 adult female 30day    5087 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0004106 expression level Developmental Stage   Expression Level embryo 00-02hr    9492 embryo 02-04hr    15569 embryo 04-06hr    16247 embryo 06-08hr    11575 embryo 08-10hr    9521 embryo 10-12hr    4440 embryo 12-14hr    4565 embryo 14-16hr    1796 embryo 16-18hr    1526 embryo 18-20hr    685 embryo 20-22hr    1013 embryo 22-24hr    1698 larva L1    431 larva L2    546 larva L3 12hr old    428 larva L3 puffstage 1-2    1385 larva L3 puffstage 3-6    1678 larva L3 puffstage 7-9    2677 white prepupae new    2405 white prepupae 12hr    2959 white prepupae 24hr    2719 pupae 2d postWPP    1597 pupae 3d postWPP    537 pupae 4d postWPP    371 adult male 01day    386 adult male 05day    579 adult male 30day    433 adult female 01day    1657 adult female 05day    5871 adult female 30day    5087 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (9492) embryo 02-04hr  (15569) embryo 04-06hr  (16247) embryo 06-08hr  (11575) embryo 08-10hr  (9521) embryo 10-12hr  (4440) embryo 12-14hr  (4565) embryo 14-16hr  (1796) embryo 16-18hr  (1526) embryo 18-20hr  (685) embryo 20-22hr  (1013) embryo 22-24hr  (1698) larva L1  (431) larva L2  (546) larva L3 12hr old  (428) larva L3 puffstage 1-2  (1385) larva L3 puffstage 3-6  (1678) larva L3 puffstage 7-9  (2677) white prepupae new  (2405) white prepupae 12hr  (2959) white prepupae 24hr  (2719) pupae 2d postWPP  (1597) pupae 3d postWPP  (537) pupae 4d postWPP  (371) adult male 01day  (386) adult male 05day  (579) adult male 30day  (433) adult female 01day  (1657) adult female 05day  (5871) adult female 30day  (5087) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (9492) embryo 02-04hr  (15569) embryo 04-06hr  (16247) embryo 06-08hr  (11575) embryo 08-10hr  (9521) embryo 10-12hr  (4440) embryo 12-14hr  (4565) embryo 14-16hr  1796 embryo 16-18hr  1526 embryo 18-20hr    685 embryo 20-22hr    1013 embryo 22-24hr  1698 larva L1    431 larva L2    546 larva L3 12hr old    428 larva L3 puffstage 1-2    1385 larva L3 puffstage 3-6  1678 larva L3 puffstage 7-9  (2677) white prepupae new  2405 white prepupae 12hr  (2959) white prepupae 24hr  (2719) pupae 2d postWPP  1597 pupae 3d postWPP    537 pupae 4d postWPP    371 adult male 01day    386 adult male 05day    579 adult male 30day    433 adult female 01day  1657 adult female 05day  (5871) adult female 30day  (5087) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    9492 embryo 02-04hr  15569 embryo 04-06hr  16247 embryo 06-08hr  11575 embryo 08-10hr    9521 embryo 10-12hr    4440 embryo 12-14hr    4565 embryo 14-16hr    1796 embryo 16-18hr    1526 embryo 18-20hr    685 embryo 20-22hr    1013 embryo 22-24hr    1698 larva L1    431 larva L2    546 larva L3 12hr old    428 larva L3 puffstage 1-2    1385 larva L3 puffstage 3-6    1678 larva L3 puffstage 7-9    2677 white prepupae new    2405 white prepupae 12hr    2959 white prepupae 24hr    2719 pupae 2d postWPP    1597 pupae 3d postWPP    537 pupae 4d postWPP    371 adult male 01day    386 adult male 05day    579 adult male 30day    433 adult female 01day    1657 adult female 05day    5871 adult female 30day    5087 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    9492 embryo 02-04hr    15569 embryo 04-06hr    16247 embryo 06-08hr    11575 embryo 08-10hr    9521 embryo 10-12hr    4440 embryo 12-14hr    4565 embryo 14-16hr    1796 embryo 16-18hr    1526 embryo 18-20hr    685 embryo 20-22hr    1013 embryo 22-24hr    1698 larva L1    431 larva L2    546 larva L3 12hr old    428 larva L3 puffstage 1-2    1385 larva L3 puffstage 3-6    1678 larva L3 puffstage 7-9    2677 white prepupae new    2405 white prepupae 12hr    2959 white prepupae 24hr    2719 pupae 2d postWPP    1597 pupae 3d postWPP    537 pupae 4d postWPP    371 adult male 01day    386 adult male 05day    579 adult male 30day    433 adult female 01day    1657 adult female 05day    5871 adult female 30day    5087 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0004106    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0004106 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: larval trachea, adult testis. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0004106 expression level Tissue   Expression Level Larval Central Nervous System    694.675 Larval Midgut    44.9 Larval Hindgut    56.1 Larval Malpighian Tubules    24.2 Larval Fat Body    86.3 Larval Salivary Gland    26.4 Larval Trachea    217.975 Larval Carcass    96.75 Adult Head    9.6 Adult Eye    15.275 Adult Brain    4.1 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut    25.7 Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body    8.2 Adult Salivary Gland no informative data Adult Heart    3.275 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    882.2 Adult Testis    194.6 Adult Male Accessory Gland    5.2 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (694.675) Larval Midgut    44.9 Larval Hindgut    56.1 Larval Malpighian Tubules    24.2 Larval Fat Body    86.3 Larval Salivary Gland    26.4 Larval Trachea    217.975 Larval Carcass    96.75 Adult Head    9.6 Adult Eye    15.275 Adult Brain    4.1 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut    25.7 Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body    8.2 Adult Salivary Gland no informative data Adult Heart    3.275 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary  (882.2) Adult Testis    194.6 Adult Male Accessory Gland    5.2 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    694.675 Larval Midgut    44.9 Larval Hindgut    56.1 Larval Malpighian Tubules    24.2 Larval Fat Body    86.3 Larval Salivary Gland    26.4 Larval Trachea    217.975 Larval Carcass    96.75 Adult Head    9.6 Adult Eye    15.275 Adult Brain    4.1 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut    25.7 Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body    8.2 Adult Salivary Gland no informative data Adult Heart    3.275 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    882.2 Adult Testis    194.6 Adult Male Accessory Gland    5.2 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    694.675 Larval Midgut    44.9 Larval Hindgut    56.1 Larval Malpighian Tubules    24.2 Larval Fat Body    86.3 Larval Salivary Gland    26.4 Larval Trachea    217.975 Larval Carcass    96.75 Adult Head    9.6 Adult Eye    15.275 Adult Brain    4.1 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut    25.7 Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body    8.2 Adult Salivary Gland no informative data Adult Heart    3.275 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    882.2 Adult Testis    194.6 Adult Male Accessory Gland    5.2 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0004106 expression level Tissue   Expression Level Larval Central Nervous System    694.675 Larval Midgut    44.9 Larval Hindgut    56.1 Larval Malpighian Tubules    24.2 Larval Fat Body    86.3 Larval Salivary Gland    26.4 Larval Trachea    217.975 Larval Carcass    96.75 Adult Head    9.6 Adult Eye    15.275 Adult Brain    4.1 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut    25.7 Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body    8.2 Adult Salivary Gland no informative data Adult Heart    3.275 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    882.2 Adult Testis    194.6 Adult Male Accessory Gland    5.2 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  694.675 Larval Midgut    44.9 Larval Hindgut    56.1 Larval Malpighian Tubules    24.2 Larval Fat Body    86.3 Larval Salivary Gland    26.4 Larval Trachea    217.975 Larval Carcass    96.75 Adult Head    9.6 Adult Eye    15.275 Adult Brain    4.1 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut    25.7 Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body    8.2 Adult Salivary Gland no informative data Adult Heart    3.275 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary  (882.2) Adult Testis    194.6 Adult Male Accessory Gland    5.2 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    694.675 Larval Midgut    44.9 Larval Hindgut    56.1 Larval Malpighian Tubules    24.2 Larval Fat Body    86.3 Larval Salivary Gland    26.4 Larval Trachea    217.975 Larval Carcass    96.75 Adult Head    9.6 Adult Eye    15.275 Adult Brain    4.1 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut    25.7 Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body    8.2 Adult Salivary Gland no informative data Adult Heart    3.275 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    882.2 Adult Testis    194.6 Adult Male Accessory Gland    5.2 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    694.675 Larval Midgut    44.9 Larval Hindgut    56.1 Larval Malpighian Tubules    24.2 Larval Fat Body    86.3 Larval Salivary Gland    26.4 Larval Trachea    217.975 Larval Carcass    96.75 Adult Head    9.6 Adult Eye    15.275 Adult Brain    4.1 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut    25.7 Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body    8.2 Adult Salivary Gland no informative data Adult Heart    3.275 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    882.2 Adult Testis    194.6 Adult Male Accessory Gland    5.2 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut     Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body     Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    9.6   NA  Eye    15.275   NA  Brain    4.1   694.675  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    no informative data   NA  Crop    no informative data   44.9  Midgut    25.7   56.1  Hindgut    no informative data   24.2  Malpighian Tubules    no informative data   86.3  Fat Body    8.2   26.4  Salivary Gland    no informative data   NA  Heart    3.275   217.975  Trachea    NA   NA  VirginFemale Spermatheca    no informative data   NA  InseminatedFemale Spermatheca    no informative data   NA  Ovary    882.2   NA  Testis    194.6   NA  Male Accessory Gland    5.2   96.75  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_17
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004106 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5363-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for cdc2 Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL41407 cdc2GD10728 lethal (with cdc2B47) cdc2GT-000294 lethal (with cdc2GT-000294) cdc2B47 lethal | embryonic stage | maternal effect cdc2D57 lethal | embryonic stage | recessive cdc2E51Q lethal | heat sensitive cdc2AF.hs lethal | pupal stage | recessive cdc2216A cdc2216P cdc2B47 cdc2E1-4 cdc2E1-9 cdc2E1-23 cdc2E1-24 cdc2E10 lethal | recessive cdc2216A cdc2216P cdc2B47 cdc2D57 cdc2E1-9 cdc2E1-23 cdc2E10 lethal | recessive | heat sensitive cdc2B47 cdc2E1-24 semi-lethal | pupal stage, with Scer\GAL4pnr-MD237 cdc2GD10728 Sterility Allele female sterile cdc2AF.hs Other Phenotypes Allele decreased cell number | heat sensitive cdc2A171T decreased cell number | somatic clone cdc2E1-24 increased cell size | heat sensitive cdc2A171T increased cell size | recessive | somatic clone cdc2E1-24 mitotic cell cycle defective | heat sensitive cdc2A171T cdc2AF.hs neuroanatomy defective | larval stage, with Scer\GAL41407 cdc2GD10728 size defective | cell autonomous | somatic clone cdc2E1-24 size defective | cell non-autonomous | somatic clone cdc2E1-24 visible, with Scer\GAL4pnr-MD237 cdc2GD10728 visible | heat sensitive cdc2216P cdc2E1-24 visible | recessive | somatic clone cdc2E1-24 wild-type cdc2+t5.8 cdc2hs.PS Phenotype manifest in Allele A1-7 dorsal acute muscle 1 | ectopic cdc2E51Q A1-7 dorsal acute muscle 1 | ectopic, with cdc2A171T cdc2B47 A1-7 dorsal acute muscle 1 | ectopic, with cdc2B47 cdc2A171T adult abdomen cdc2216P cdc2E1-24 annulate lamellae | heat sensitive cdc2A171T central nervous system cdc2B47 cdc2E1-24 centriole cdc2A171T chaeta | somatic clone cdc2E1-24 cyst cell cdc2AF.hs embryonic/larval brain cdc2B47 cdc2E1-23 cdc2E1-9 cdc2E10 embryonic/larval neuroblast | larval stage, with Scer\GAL41407 cdc2GD10728 embryonic/larval optic lobe | heat sensitive (with cdc2B47) cdc2E1-24 embryonic/larval optic lobe | heat sensitive (with cdc2E1-24) cdc2B47 embryonic/larval salivary gland | embryonic stage cdc2B47 cdc2E1-24 embryonic neuroblast, with cdc2A171T cdc2B47 embryonic neuroblast, with cdc2B47 cdc2A171T embryonic neuroblast & spindle cdc2E51Q ganglion mother cell | larval stage, with Scer\GAL41407 cdc2GD10728 ganglion mother cell GMC4-2a cdc2E51Q ganglion mother cell GMC4-2a, with Scer\GAL4sca-109-68 cdc2E51Q.Scer\UAS ganglion mother cell GMC4-2a & spindle cdc2E51Q histoblast cdc2B47 histoblast & nucleus | conditional ts (with cdc2B47) cdc2E1-24 histoblast & nucleus | conditional ts (with cdc2E1-24) cdc2B47 imaginal disc cdc2216A cdc2216P cdc2B47 cdc2D57 cdc2E1-23 cdc2E1-24 cdc2E1-9 cdc2E10 imaginal disc | heat sensitive (with cdc2B47) cdc2E1-24 imaginal disc | heat sensitive (with cdc2E1-24) cdc2B47 imaginal disc | larval stage cdc2B47 cdc2E1-23 cdc2E1-9 cdc2E10 mesothoracic tergum, with Scer\GAL4pnr-MD237 cdc2GD10728 mitotic cell cycle cdc2AF.hs nuclear pore | heat sensitive cdc2A171T oocyte | temperature conditional (with cdc2B47) cdc2E1-24 oocyte | temperature conditional (with cdc2E1-24) cdc2B47 optic lobe cdc2B47 polar body nucleus cdc2A171T pole cell cdc2AF.hs RP2 neuron | ectopic cdc2E51Q RP2 neuron | ectopic, with cdc2A171T cdc2B47 RP2 neuron | ectopic, with cdc2B47 cdc2A171T secondary spermatogonium cdc2AF.hs spindle cdc2A171T tormogen cell | heat sensitive (with cdc2B47) cdc2E1-24 tormogen cell | heat sensitive (with cdc2E1-24) cdc2B47 trichogen cell | heat sensitive (with cdc2B47) cdc2E1-24 trichogen cell | heat sensitive (with cdc2E1-24) cdc2B47 trichome | somatic clone cdc2E1-24 wing | anterior compartment cdc2E1-24 wing | somatic clone cdc2E1-24 wing cell cdc2E1-24 wing cell | somatic clone cdc2E1-24 wing disc cdc2A171T wing disc | anterior compartment, with Scer\GAL4en-e16E cdc2Scer\UAS.cWa wing hair | ectopic | somatic clone cdc2B47 wing hair | somatic clone cdc2B47
Classical Alleles ( 15 )
For All Classical Alleles Show
Allele of cdc2 Class Mutagen Stocks Known lesion cdc2c03495 piggyBac transposase 2 -- cdc2B47 loss of function allele, amorphic allele - genetic evidence ethyl methanesulfonate 1 Yes cdc2E1-23 amorphic allele - genetic evidence ethyl methanesulfonate 1 Yes cdc2E1-24 hypomorphic allele - genetic evidence ethyl methanesulfonate 1 Yes cdc2GT-000294 P-element activity 1 -- cdc2D57 amorphic allele - genetic evidence ethyl methanesulfonate 0 Yes cdc2E1-9 amorphic allele - genetic evidence ethyl methanesulfonate 0 Yes cdc2E10 amorphic allele - genetic evidence ethyl methanesulfonate 0 Yes cdc2216A hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes cdc2216P hypomorphic allele - genetic evidence PM hybrid dysgenesis P-element activity 0 Yes cdc22 0 -- cdc23 0 -- cdc2E1-4 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes cdc2E51Q 0 Yes cdc2unspecified 0 --
Alleles Carried on Transgenic Constructs ( 18 )
For All Alleles Carried on Transgenic Constructs Show
Allele of cdc2 Class Mutagen Stocks Known lesion cdc2GD10728 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes cdc2Scer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 2 Yes cdc2GL00262 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes cdc2HMS01531 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes cdc2JF03004 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes cdc2KK102709 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes cdc2+t5.8 in vitro construct - genomic fragment 0 Yes cdc2A171T in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes cdc2AF.hs in vitro construct - amino acid replacement in vitro construct - regulatory fusion 0 Yes cdc2E51Q.Scer\UAS in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes cdc2G177E in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes cdc2G43E in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes cdc2hs.PS in vitro construct - regulatory fusion 0 Yes cdc2K33R.T161A.Scer\UAS in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes cdc2P131S in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes cdc2Scer\UAS.cHa in vitro construct - regulatory fusion 0 Yes cdc2Scer\UAS.cWa in vitro construct - regulatory fusion 0 Yes cdc2T161A.Scer\UAS in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)BSC209 (Christensen and Cook, 2006.8.30) Df(2L)BSC342 (Christensen and Cook, 2007.10.29) Df(2L)G2 (Clegg et al., 1993) Df(2L)J2 (Sinclair et al., 1992, Clegg et al., 1993, Smith et al., 1993) Df(2L)J3 (Clegg et al., 1993) Df(2L)J16 (Clegg et al., 1993, Clegg et al., 1993) Df(2L)J17 (Clegg et al., 1993) Df(2L)J27 (Stern et al., 1993, Clegg et al., 1993, Sigrist et al., 1995) Df(2L)J39 (Clegg et al., 1993) Df(2L)J77 (Clegg et al., 1993, Clegg et al., 1993) Df(2L)J106 (Clegg et al., 1993)
Not disrupted in	Df(2L)J1 (Clegg et al., 1993) Df(2L)J17 (Clegg et al., 1993)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data heat-shock construct P{hs-cdc2.S} NA P{HS-cdc2AF} NA UAS construct P{GD10728} NA P{KK102709} NA P{TRiP.GL00262} NA P{TRiP.HMS01531} NA P{TRiP.JF03004} NA P{UAS-cdc2.E51Q} NA P{UAS-cdc2.H} NA P{UAS-cdc2.K33R.T161A} NA P{UAS-cdc2.T161A} NA P{UAS-cdc2.W} NA P{UAS-Cdk1-myc} NA characterization construct P{Dm.cdc2} NA P{Dmcdc2A171T} NA P{G43E} NA P{G177E} NA P{P131S} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{}cdc2216P NA P{GT1}cdc2GT-000294 NA PBac{PB}cdc2c03495 NA
Gene Ontology: Function, Process & Cellular Component ( 23 unique terms )
Terms Based on Experimental Evidence ( 15 terms )
Molecular Function
CV term Evidence References
cyclin-dependent protein kinase activity inferred from genetic interaction with Saccharomyces CDC28 (Lehner and O'Farrell, 1990) protein binding inferred from physical interaction with CycB3 (assigned by UniProtKB) (Jacobs et al., 1998)
Biological Process
CV term Evidence References
asymmetric neuroblast division inferred from mutant phenotype (Tio et al., 2001) cell cycle inferred from mutant phenotype (Kiger et al., 2003) cellular process inferred from mutant phenotype (Boutros et al., 2004) G1/S transition of mitotic cell cycle inferred from genetic interaction with Saccharomyces CDC28 (Lehner and O'Farrell, 1990) G2/M transition of mitotic cell cycle inferred from genetic interaction with Saccharomyces CDC28 (Lehner and O'Farrell, 1990) inferred from mutant phenotype (Stern et al., 1993) germarium-derived cystoblast division inferred from mutant phenotype (Jin et al., 2005) male meiosis inferred from mutant phenotype (Jin et al., 2005) neurogenesis inferred from mutant phenotype (Neumüller et al., 2011) protein phosphorylation inferred from direct assay (Du et al., 1996) regulation of protein localization inferred from mutant phenotype (Royou et al., 2002) response to DNA damage stimulus inferred from mutant phenotype (Ravi et al., 2009) spermatogonial cell division inferred from mutant phenotype (Jin et al., 2005)
Cellular Component
CV term Evidence References
microtubule associated complex inferred from direct assay (Hughes et al., 2008)
Terms Based on Predictions or Assertions ( 11 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR002290, InterPro:IPR017441 (FlyBase Curators et al., 2004-) cyclin-dependent protein kinase activity inferred from sequence or structural similarity with Saccharomyces CDC28 (Lehner and O'Farrell, 1990) non-traceable author statement (Swiss-Prot Project Members, 1991.11.1, Swiss-Prot Project Members, 1991.11.1) protein serine/threonine kinase activity non-traceable author statement (Morrison et al., 2000)
Biological Process
CV term Evidence References
asymmetric neuroblast division traceable author statement (Schaefer and Knoblich, 2001) male meiosis I traceable author statement (Fuller, 1998) meiotic G2/MI transition traceable author statement (Fuller, 1998) phosphorylation of RNA polymerase II C-terminal domain non-traceable author statement (Swiss-Prot Project Members, 1991.11.1, Swiss-Prot Project Members, 1991.11.1) protein phosphorylation non-traceable author statement (Morrison et al., 2000) regulation of cell cycle non-traceable author statement (Swiss-Prot Project Members, 1991.11.1, Swiss-Prot Project Members, 1991.11.1) spermatogenesis traceable author statement (Fuller, 1998)
Cellular Component
CV term Evidence References
nucleus non-traceable author statement (Swiss-Prot Project Members, 1991.11.1, Swiss-Prot Project Members, 1991.11.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions cdc2 allele Gene References cdc2AF.hs CycA (Sprenger et al., 1997) CycB (Su et al., 2000) cdc2B47 arm (Greaves et al., 1999) CycA (Hayashi and Yamaguchi, 1999) CycD (Emmerich et al., 2004) wts (Tao et al., 1999) cdc2D57 CycB (Ji et al., 2002) cdc2E1-23 CycD (Emmerich et al., 2004) cdc2E1-24 CycA (Hayashi and Yamaguchi, 1999) wts (Tao et al., 1999) cdc2E10 Myb (Okada et al., 2002) cdc2hs.PS CycA (Parry and O'Farrell, 2001) CycB (Parry and O'Farrell, 2001) Myb (Katzen et al., 1998) cdc2Scer\UAS.cHa CycA (Hayashi and Yamaguchi, 1999) cdc2unspecified Myt1 (Price et al., 2002) wee (Price et al., 2002) unspecified Cdc37 (Cutforth and Rubin, 1994) CycB3 (Parry and O'Farrell, 2001) esg (Hayashi, 1996) os (Mukherjee et al., 2006) shg (Greaves et al., 1999)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 60495 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0004106 DroID - A comprehensive database of gene and protein interactions. • FBgn0004106 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34411
Orthologs
Genome-wide drosophilid orthologs	Dana\GF14103 Dere\GG23938 Dgri\GH13856 Dmoj\GI18275 Dper\GL19151 Dpse\GA24058 Dsec\GM11695 Dsim\GD22264 Dvir\GJ15416 Dwil\GK23499 Dyak\GE26009
Curated drosophilid orthologs
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL008621-PA Aedes aegypti (mosquito) AGAP009459-PA Anopheles gambiae (mosquito) XP_001951857.1 Acyrthosiphon pisum (pea aphid) XP_001951975.1 Acyrthosiphon pisum (pea aphid) At3g48750.1 Arabidopsis thaliana (wall cress) 36412 Batrachochytrium dendrobatidis (chytrid fungus) 114825 Branchiostoma floridae (lancelet) XP_001891803.1 Brugia malayi (roundworm nematode) BGIBMGA013134-PA Bombyx mori (silk worm) ENSBTAP00000013337 Bos taurus (bovine) CAL0002090 Candida albicans (a form of yeast) CN15453 Caenorhabditis brenneri (small nematode) CBP08360 Caenorhabditis briggsae (nematode) CE00315 Caenorhabditis elegans (worm) ENSCAFP00000019027 Canis familiaris (dog) CAGL0H07535g Candida glabrata (haploid yeast) ENSCINP00000012350 Ciona intestinalis (sea squirt) JA05722 Caenorhabditis japonica (nematode) CME119C Cyanidioschyzon merolae (red alga) cn03557 Cryptococcus neoformans (yeast-like fungus) CPIJ001155 Culex pipens (mosquito) ENSCPOP00000004862 Cavia porcellus (guinea pig) 127285 Chlamidomonas reinhardtii (green alga) RP46379 Caenorhabditis remanei (nematode) ENSCSAVP00000002794 Ciona savignyi (sedentary tunicate) 148267 Capitella spl (polychaete worm) DEHA2G10714g Debaryomyces Hansenii (yeast) 299546 Daphnia pulex (daphnia) ENSDARP00000072192 Danio rerio (zebra fish) ENSECAP00000007813 Equus caballus (horse) XP_652398 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000003296 Gymnopilus aculeatus (mushroom) ENSGALP00000004867 Gallus gallus (chicken) 185958 Hypsipyla robusta (cedar shoot borer) ENSP00000378699 Homo sapiens (human) ISCW014734-PA Ixodes scapularis (deer tick) KLLA0B09790g Kluyveromyces lactis (yeast) 230226 Lottia gigantea (owl limpet) 17670 Monocosta brevicollis (choanoflagellate) ENSMODP00000021329 Monodelphis domestica (gray opossum) ENSMMUP00000035798 Macaca mulatta (rhesus monkey) ENSMUSP00000020099 Mus musculus (house mouse) 228964 Nematostella vectensis (starlet anemone) XP_001600339.1 Nasonia vitripennis (wasp) ENSOANP00000006989 Ornithorynchus anatinus (platypus) ENSORLP00000024000 Oryzias latipes (japanese killifish) LOC_Os03g02680.1 Oryza sativa (asian rice) 16752 Ostreococcus tauri (green alga) PHUM009792-PA Pediculus humanus (human body louse) PP24419 Pristionchus pacificus (nematode) 171224 Physcomitrella patens (moss) ENSPPYP00000002808 Pongo pygmaeus (orangutan) 71299 Phytophthora ramorum (sudden oak death pathogen) 109106 Phytophthora sojae (root rot pathogen) 648419 Populus trichocarpa (black cottonwood) ENSPTRP00000050657 Pan troglodytes (chimpanzee) ENSRNOP00000000783 Rattus norvegicus (norway rat) 4999033 Sorghum bicolor (sorghum) YBR160W Saccharomyces cerevisiae (budding yeast) Smp_080730 Schistosoma mansoni (trematode parasite) SPBC11B10.09 Schizosaccharomyces pombe (fission yeast) XP_781415.1 Strongylocentrotus purpuratus (purple sea urchin) 55283 Trichoplax adhaerens (metazoa) XP_967826.1 Tribolium castaneum (red flour beetle) ENSTNIP00000005755 Tetraodon nigroviridis (green spotted pufferfish) 268410 Thalassiosira pseudonana (marine diatom) ENSTRUP00000007140 Takifugu rubripes (pufferfish Takifugu) 206.m00033 Tetrahymena thermophila (ciliate protozoa) 87854.m00199 Trichomonas vaginalis (parasitic flagellated protozoan) YALI0B10758g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB19515 NV11863 LH16408 ISCW014734 FBgn0243052 FBgn0225461 FBgn0202609 FBgn0193672 FBgn0166638 JGI_V11_299546 FBgn0245457 FBgn0156750 FBgn0141014 FBgn0121332 FBgn0116077 FBgn0091130 CPIJ001155 BGIBMGA013134 ACYPI009520 ACYPI008349 GB19434 AGAP009459 AAEL008621 PHUM448370 GLEAN_15375
Stocks & Reagents
Stocks Listed in FlyBase ( 14 )
Bloomington	6642 w*; P{UAS-Cdk1-myc}II.2 6638 w*; P{UAS-Cdk1-myc}III.1 28368 y1 v1; P{TRiP.JF03004}attP2 11302 w1118; PBac{PB}cdc2c03495/CyO 20980 w1118; P{GT1}cdc2GT-000294/CyO 35350 y1 sc* v1; P{TRiP.GL00262}attP2 6629 cdc2E1-23 b1 pr1 cn1/CyO 36117 y1 sc* v1; P{TRiP.HMS01531}attP40
Harvard	- PBac{PB}cdc2c03495
VDRC	v106130 P{KK102709}VIE-260B v41838 w1118; P{GD10728}v41838/TM3 v41839 w1118; P{GD10728}v41839/TM3
	More stocks available...
Genomic Clones ( 2 )
	BACR30M19 BACR48K04 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 46 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD38718
Other clones	DPiM_LD38718
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LD07161 LD10840 LD26702 LD31004 LD31547 LD45355 RE03445 RE03688 RE08819 RE10846 RE14963 RE33541 RE36090 RE47569 RE52268 RE52532 RE55296 RE55767 RE58009 RE66482 RE69930 RE71275 RE73468 SD16469
Other clones	99632 146665 153676 CK01.69A.C3 CK02479 Dmel_dig_013749_0668_0912 EC051004 EC051355 EC051503 EC053984 EC054483 EC054877 EC055873 EC056444 EK055210 EK056247 EK056806 EK221951 EK249264 EK257713
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0004106 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34411
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: cdc2 CG5363 (Li, 1999.11)
Source for database merge of
Additional comments
Other Comments
	Treatment of S2-derived S2-NP cells with dsRNA made from templates generated with primers directed against cdc2 results in a decrease in Stat92E tyrosine phosphorylation. (Baeg et al., 2005) Myt1 inhibitory phosphorylation of cdc2 is required for regulating multiple aspects of cell cycle behaviour during spermatogenesis. (Jin et al., 2005) When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, an increase in the proportion of G2/M phase cells, a decrease in cell size, a decrease in cytokinetic index, a decrease in the ratio of cells in prometaphase and metaphase versus the total number of mitotic cells and chromosome abnormalities are seen. (Bettencourt-Dias et al., 2004) RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells. (Boutros et al., 2004) RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in Kc167 and S2R+ cells: cell size is increased, microtubules are uniform or disorganised, cell shape is irregular, and cell number is decreased indicative of a failure in cell cycle progression through G1 to S and G2 to M stages. (Kiger et al., 2003) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) By attenuating cdc2 function without blocking mitosis, normally asymmetric neural progenitor divisions become defective, failing to correctly localise asymmetric components during mitosis and/or to resolve distinct sibling fates. (Tio et al., 2001) Neural progenitor asymmetric divisions require cdc2. (Tio et al., 2001) polo protein kinase, in embryos, has a narrow peak of activity during late anaphase-telophase, separable from the peak of cdc2 activity. (Tavares and Glover, 1997) A cdc2-dependent checkpoint acts to maintain diplody. In G2, esg is required to maintain a high level of G2/M cdk (a complex that includes the catalytic subunit encoded by cdc2 and a regulatory subunit G2 cyclin) that actively inhibits the entry into S phase. (Hayashi, 1996) cdc2 is required for both meiotic divisions during spermatogenesis. cdc2 function is activated by twe phosphatase. (Sigrist et al., 1995) Mutations in fzy result in metaphase arrest, neither CycA, CycB or CycB3 are degraded in this arrest. Inactivation of a temperature sensitive cdc2 in fzy metaphase arrest causes a reversion to interphase morphology. This reversion is not accompanied by completion of mitosis so there is no increase in anaphase cells or change in cell number or size. (Sigrist et al., 1995) The activity of cdc2 is highly sensitive to Cdc37 levels, suggesting that the two genes may act in a common pathway to regulate cell cycle control. (Cutforth and Rubin, 1994) During development changing levels of cell cycle regulators alters the rate limiting step and the mechanism governing progress of the cell cycle. Three phases of developmental progression of cell cycle regulation have been defined. The first seven cycles run in the presence of constitutively active cdc2. Later during cycles 8-13 increasing mitotic destruction of cyclins drives oscillations in cdc2 activity, cyclin accumulation becomes the rate limiting step for mitosis. Degradation of maternally supplied stg causes tyrosine dephosphorylation of cdc2 to become rate limiting for mitosis beginning in cycle 14. (Edgar et al., 1994) Yeast interaction mating has been used to characterise Cyclin-dependent kinase interactor proteins (the prey) in hunts with either cdc2 or cdc2c as baits. (Finley and Brent, 1994) Twelve (unnamed) recessive lethal alleles have been isolated during a cytogenetic analysis of chromosomal region 31. (Clegg et al., 1993) Preliminary genetic and molecular analysis of mutations of cdc2. (Clegg et al., 1993) In contrast to the polo gene product, for which kinase activity peaks cyclically at late anaphase/telophase, CycB-associated cdc2 histone H1 kinase activity is maximal upon entry into mitosis during the rapid syncytial mitoses. (Fenton and Glover, 1993) cdc2 gene product is not essential for DNA replication during embryogenesis. (Smith et al., 1993) cdc2 function is essential for cell proliferation throughout development, though block occurs in G2 and no function in S phase could be identified. While the mitotic proliferation of imaginal cells was blocked in mutants, non-imaginal cells continue to grow and endoreplicate their DNA. cdc2c cannot compensate for lack of cdc2 function indicating the independence of their action. (Stern et al., 1993) Recombination mapping and intensive mapping studies of the Su(var)207 and Su(var)2-1216 chromosomes suggested a closely linked second site lethal. Genetic and molecular analysis of the second site lethal revealed it to be an allele of the cdc2 gene (Lehner, EMBO J. 9: 3573--3581, Jimenez, EMBO J. 9: 3565--3571). (Sinclair et al., 1992) Cross-species complementation tests reveal that a cdc2 cDNA clone will rescue S.cerevisiae deficient in cyclin gene functions. (Leopold and O'Farrell, 1991) The sequence and expression pattern of cdc2 has been determined. (Jimenez et al., 1990) Northern blot and in situ hybridization studies demonstrate that cdc2 and cdc2c are co-expressed during embryogenesis. cdc2 expression is correlated with cell proliferation. (Lehner and O'Farrell, 1990) Complements yeast temperature-sensitive cdc28 alleles.
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057449 RefSeq (Proteins) • NP_476797 DDBJ / EMBL / GenBank • AAF52932 AAL28998 AC007451 AI519205 AW943439 AY061450 CAA40723 CAA40733 S66801 S66804 S66805 S66807 S66810 X57485 X57496 Entrez Gene - A searchable database of RefSeq genes. • 34411 UniProtKB/Swiss-Prot • P23572
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) Serine/threonine-protein kinase, catalytic domain (IPR002290) Serine/threonine-protein kinase, active site (IPR008271) Protein kinase-like domain (IPR011009) Protein kinase, ATP binding site (IPR017441) Serine/threonine-protein kinase-like domain (IPR017442)
Linkouts
	BioGRID - A database of protein and genetic interactions • 60495 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0004106 DroID - A comprehensive database of gene and protein interactions. • FBgn0004106 DRSC - Results from RNAi screens. • FBgn0004106 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004106 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5363-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0004106 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34411 InParanoid A subset of ortholog calls from InParanoid. • AAEL008621-PA Aedes aegypti (mosquito) AGAP009459-PA Anopheles gambiae (mosquito) XP_001951857.1 Acyrthosiphon pisum (pea aphid) XP_001951975.1 Acyrthosiphon pisum (pea aphid) At3g48750.1 Arabidopsis thaliana (wall cress) 36412 Batrachochytrium dendrobatidis (chytrid fungus) 114825 Branchiostoma floridae (lancelet) XP_001891803.1 Brugia malayi (roundworm nematode) BGIBMGA013134-PA Bombyx mori (silk worm) ENSBTAP00000013337 Bos taurus (bovine) CAL0002090 Candida albicans (a form of yeast) CN15453 Caenorhabditis brenneri (small nematode) CBP08360 Caenorhabditis briggsae (nematode) CE00315 Caenorhabditis elegans (worm) ENSCAFP00000019027 Canis familiaris (dog) CAGL0H07535g Candida glabrata (haploid yeast) ENSCINP00000012350 Ciona intestinalis (sea squirt) JA05722 Caenorhabditis japonica (nematode) CME119C Cyanidioschyzon merolae (red alga) cn03557 Cryptococcus neoformans (yeast-like fungus) CPIJ001155 Culex pipens (mosquito) ENSCPOP00000004862 Cavia porcellus (guinea pig) 127285 Chlamidomonas reinhardtii (green alga) RP46379 Caenorhabditis remanei (nematode) ENSCSAVP00000002794 Ciona savignyi (sedentary tunicate) 148267 Capitella spl (polychaete worm) DEHA2G10714g Debaryomyces Hansenii (yeast) 299546 Daphnia pulex (daphnia) ENSDARP00000072192 Danio rerio (zebra fish) ENSECAP00000007813 Equus caballus (horse) XP_652398 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000003296 Gymnopilus aculeatus (mushroom) ENSGALP00000004867 Gallus gallus (chicken) 185958 Hypsipyla robusta (cedar shoot borer) ENSP00000378699 Homo sapiens (human) ISCW014734-PA Ixodes scapularis (deer tick) KLLA0B09790g Kluyveromyces lactis (yeast) 230226 Lottia gigantea (owl limpet) 17670 Monocosta brevicollis (choanoflagellate) ENSMODP00000021329 Monodelphis domestica (gray opossum) ENSMMUP00000035798 Macaca mulatta (rhesus monkey) ENSMUSP00000020099 Mus musculus (house mouse) 228964 Nematostella vectensis (starlet anemone) XP_001600339.1 Nasonia vitripennis (wasp) ENSOANP00000006989 Ornithorynchus anatinus (platypus) ENSORLP00000024000 Oryzias latipes (japanese killifish) LOC_Os03g02680.1 Oryza sativa (asian rice) 16752 Ostreococcus tauri (green alga) PHUM009792-PA Pediculus humanus (human body louse) PP24419 Pristionchus pacificus (nematode) 171224 Physcomitrella patens (moss) ENSPPYP00000002808 Pongo pygmaeus (orangutan) 71299 Phytophthora ramorum (sudden oak death pathogen) 109106 Phytophthora sojae (root rot pathogen) 648419 Populus trichocarpa (black cottonwood) ENSPTRP00000050657 Pan troglodytes (chimpanzee) ENSRNOP00000000783 Rattus norvegicus (norway rat) 4999033 Sorghum bicolor (sorghum) YBR160W Saccharomyces cerevisiae (budding yeast) Smp_080730 Schistosoma mansoni (trematode parasite) SPBC11B10.09 Schizosaccharomyces pombe (fission yeast) XP_781415.1 Strongylocentrotus purpuratus (purple sea urchin) 55283 Trichoplax adhaerens (metazoa) XP_967826.1 Tribolium castaneum (red flour beetle) ENSTNIP00000005755 Tetraodon nigroviridis (green spotted pufferfish) 268410 Thalassiosira pseudonana (marine diatom) ENSTRUP00000007140 Takifugu rubripes (pufferfish Takifugu) 206.m00033 Tetrahymena thermophila (ciliate protozoa) 87854.m00199 Trichomonas vaginalis (parasitic flagellated protozoan) YALI0B10758g Yarrowia lipolytica (nonconventional yeast) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /newgene/cdc2-1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34411 modMine - Data generated by the modENCODE project. • FBgn0004106 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB19515 NV11863 LH16408 ISCW014734 FBgn0243052 FBgn0225461 FBgn0202609 FBgn0193672 FBgn0166638 JGI_V11_299546 FBgn0245457 FBgn0156750 FBgn0141014 FBgn0121332 FBgn0116077 FBgn0091130 CPIJ001155 BGIBMGA013134 ACYPI009520 ACYPI008349 GB19434 AGAP009459 AAEL008621 PHUM448370 GLEAN_15375
Synonyms & Secondary IDs ( 26 )
Reported As
Symbol Synonym	5363 (Ravi et al., 2009) cdc (Huang and Fischer-Vize, 1996) Cdc2 (Fichelson et al., 2005, Royou et al., 2002, Juang et al., 2003, Gao and Thomas, 2004, Fichelson and Gho, 2004, Rascle et al., 2003, Schaefer and Knoblich, 2001, Potter and Xu, 2001, Wu et al., 2001, Fenger et al., 2000, Day and Lawrence, 2000, Stumpff et al., 2000, Hayashi and Yamaguchi, 1999, Su et al., 1998, Brent and Finley, 1997, Weigmann et al., 1997, Schubiger et al., 1997, Finley and Brent, 1994, Edgar et al., 1994, Clegg et al., 1993, Hochwagen, 2006, Goshima and Vale, 2005, Hediger and Gasser, 2006, Mogila et al., 2006, de Vries et al., 2005, Basto et al., 2007, Lin et al., 2004, Baig et al., 2010, Zeng et al., 2010) CDC2 (Finley and Brent, 1993, Papoulas et al., 2010) cdc2 (Karess, 2005, Sanchez-Elsner et al., 2006, Christensen and Cook, 2006.8.30, Mukherjee et al., 2006, Mummery-Widmer et al., 2009, Cryderman et al., 2005, Christensen and Cook, 2007.10.29, Takada et al., 2007, Gim et al., 2001, Baeg et al., 2007, Lin, 2008, Chia et al., 2008, Somma et al., 2008, Von Stetina et al., 2008, Heriche et al., 2003, Tanaka-Matakatsu et al., 2007, Brunk et al., 2007, Morris et al., 2006, Chen et al., 2008, Tomancak et al., 2007, Beam and Moberg, 2010, Terriente-Félix et al., 2010) cdc2Dm (Sinclair et al., 1992) CDCDm (Bejarano et al., 1995) Cdk1 (Swaminathan and Pile, 2010, Swan et al., 2005, Jin et al., 2005, Stumpff et al., 2004, Vidwans et al., 2003, Balasubramanian et al., 2004, Emmerich et al., 2004, Levine, 2004, Swan and Schupbach, 2005, Onishchenko et al., 2005, Crest and Schubiger, 2005, Duncan and Su, 2004, Reis and Edgar, 2003, Jacobs et al., 2003, Lee and Orr-Weaver, 2003, Jin et al., 2004, Homola and Campbell, 2004, Crest et al., 2004, Deng and Lin, 2001, Homola et al., 2001, Su et al., 2001, Su, 2001, Ji et al., 2001, Parry and O'Farrell, 2001, Edgar and Orr-Weaver, 2001, Su and Jaklevic, 2001, Stumpff and Su, 2001, Purdy et al., 2001, Su and Garner, 2001, Kolonin and Finley, 2000, Meyer et al., 2000, Lane et al., 2000, Su et al., 2000, Lehner et al., 1999, Grosskortenhaus and Sprenger, 1999, Foley and Sprenger, 1999, Jacobs et al., 1998, Sclafani, 1998, Su and O'Farrell, 1998, Su et al., 1998, Parry and O'Farrell, 1998, Kolonin and Finley, 1998, Crest et al., 2006, Huang et al., 2007, Reber et al., 2006, Großhans et al., 2007, Onischenko et al., 2005, Chia et al., 2008, Von Stetina et al., 2008, Zielke et al., 2008, Rickmyre et al., 2007, Glavic et al., 2009, Gawlinski et al., 2007, Leismann and Lehner, 2003, Khurana et al., 2006, Li et al., 2010, Gawlinski et al., 2007, Oliveira et al., 2010) cdk1 (Bjorklund et al., 2006, Tadros et al., 2003, Ji et al., 2002, Ji et al., 2001, Glover et al., 1998, Lane et al., 1996, Hyun et al., 2006, Park et al., 2003, Stetina et al., 2008, Fisher, 2005, Lin, 2008, Brunk et al., 2007, Althoff et al., 2009, Morris et al., 2006) CDK1 (O'Farrell, 2001, Rascle et al., 2003, Avides et al., 2001, Purdy and Su, 2003, Coelho and Leevers, 2000, Royou et al., 2008, Merkle et al., 2009, Papoulas et al., 2010) Cdk-1 (Klebes et al., 2002) CDK1/CDC2 (Morrison et al., 2000) CG5363 (Ryder, 2004.9.23, Morrison et al., 2000, Keleman et al., 2009.8.5, Perkins et al., 2009, Hughes et al., 2008, Chen et al., 2008, Ni et al., 2011.7.19) Dcdc2 (Sugaya et al., 1994) DmCdc2 (Swaminathan and Pile, 2010, Kolonin and Finley, 1997, Campbell et al., 1995) Dmcdc2 (Resino and Garcia-Bellido, 2004, Goldstein et al., 1999, Hayashi and Yamaguchi, 1999, Harper and Elledge, 1998, Larochelle et al., 1998, Reed and Orr-Weaver, 1997, Hayashi, 1996, Hayashi, 1996, Sigrist et al., 1995, Sigrist et al., 1995, Cutforth and Rubin, 1994, Foe et al., 1993) Dm cdc2 (Warbrick and Glover, 1994) DmCdk1 (Kolonin and Finley, 1998) group 4 (Biggs and Zipursky, 1992) l(2)31Eh
Name Synonym	cdc2 (Somma et al., 2008) CDC2 kinase (Derenzo and Seydoux, 2004) Cdc2 kinase (Lee et al., 2001) cdc2 kinase (Brower-Toland et al., 2007) cyclin dependent kinase (Goshima and Vale, 2005) cyclin-dependent kinase (Baig et al., 2010) cyclin-dependent kinase 1 (Royou et al., 2008, Oliveira et al., 2010)
Secondary FlyBase IDs
References ( 268 )
Generate a list of	All references relating to this gene ( 268 )
List References by type	Research paper  ( 148 ) Supplementary material  ( 8 ) Review  ( 44 ) Erratum  ( 1 ) Personal communication to FlyBase  ( 10 ) Abstract  ( 47 ) FlyBase analysis  ( 2 ) Conference report  ( 1 ) Curated genome annotation  ( 2 ) Protein sequence record  ( 2 ) Computer file  ( 2 ) Automatic genome annotation  ( 1 )
Recent research papers ( 10 )
	Nakajima et al., 2011, Mol. Cell. Biol. 31(12): 2499--2512 Nonautonomous Apoptosis Is Triggered by Local Cell Cycle Progression during Epithelial Replacement in Drosophila. [FBrf0213728] Baig et al., 2010, Genetics 184(3): 731--744 The chromatin-remodeling protein Osa interacts with CyclinE in Drosophila eye imaginal discs. [FBrf0210399] Beam and Moberg, 2010, Fly 4(2): 104--116 The gang of four gene regulates growth and patterning of the developing Drosophila eye. [FBrf0211089] Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Li et al., 2010, PLoS Genet. 6(3): e1000876 Drosophila xpd regulates cdk7 localization, mitotic kinase activity, spindle dynamics, and chromosome segregation. [FBrf0210295] Oliveira et al., 2010, Nat. Cell Biol. 12(2): 185--192 Cohesin cleavage and Cdk inhibition trigger formation of daughter nuclei. [FBrf0209876] Papoulas et al., 2010, Development 137(24): 4201--4209 dFMRP and Caprin, translational regulators of synaptic plasticity, control the cell cycle at the Drosophila mid-blastula transition. [FBrf0212321] Swaminathan and Pile, 2010, Mech. Dev. 127(1-2): 96--106 Regulation of cell proliferation and wing development by Drosophila SIN3 and String. [FBrf0209854] Terriente-Félix et al., 2010, Genetics 185(2): 671--684 Identification of genes affecting wing patterning through a loss-of-function mutagenesis screen and characterization of med15 function during wing development. [FBrf0211230] Zeng et al., 2010, J. Cell. Physiol. 224(3): 766--774 Tumor suppressors Sav/scrib and oncogene ras regulate stem-cell transformation in adult Drosophila malpighian tubules. [FBrf0211181] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...