cdc2c, Dmcdc2c, Cyclin E
Please see the JBrowse view of Dmel\Cdk2 for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.50
Gene model reviewed during 5.43
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.47
Antisense UTR: 3' UTR overlaps CG17267 on opposite strand.
Gene model reviewed during 5.53
1.1 (northern blot)
314 (aa); 35.9 (kD)
Interacts with cyclin CycG.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Cdk2 using the Feature Mapper tool.
Comment: maternally deposited
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
cdc2c expression correlates temporally and spatially with cell proliferation in embryos.
GBrowse - Visual display of RNA-Seq signals
View Dmel\Cdk2 in GBrowse 2
3-69
3-72.9
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
Source for identity of: cdc2c CG10498
Source for identity of: Cdk2 cdc2c
'cdc2c' renamed to 'Cdk2' owing to: i) preferred usage in the literature; ii) better indication of function/orthology; and iii) preference of authors Lehner and O'Farrell who originally characterized and named the gene in FBrf0051651.
When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, an increase in the proportion of G1 phase cells, and increase in cell size, a decrease in the mitotic index, and cytokinetic index are seen.
RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.
RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
During mitotic cycles CycE and cdc2c kinase activity are present throughout the cell cycle. Reinitiation of DNA replication during the G2 phase of the mitotic cell cycle, therefore, is prevented by CycE/cdc2c kinase-independent regulation. Observations in CycA mutants implicate G2 cyclins in this regulation.
cdc2c cannot compensate for lack of cdc2 function, indicating the independence of their action.
Northern blot and in situ hybridization studies demonstrate that cdc2 and cdc2c are coexpressed during embryogenesis. cdc2c expression is correlated with cell proliferation.
