FB2020_06, released Dec 22, 2020

Gene: Dmel\Cdk2

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General Information
Symbol
Dmel\Cdk2
Species
D. melanogaster
Name
Cyclin-dependent kinase 2
Annotation Symbol
CG10498
Feature Type
protein_coding_gene
FlyBase ID
FBgn0004107
Gene Model Status
Current
Stock Availability
13 publicly available
Gene Snapshot
Cyclin-dependent kinase 2 (Cdk2) encodes a catalytic protein kinase subunit that can only become active after association with the product of CycE. The protein kinase activity of the CycE-Cdk2 complex controls important aspects of progression through the G1 and S phases of the cell cycle. In addition, periodic CycE-Cdk2 activity regulates progression through endoreduplication cycles. [Date last reviewed: 2019-03-07]
Other Summaries
Also Known As

cdc2c, Dmcdc2c, Cyclin E

Key Links
Genomic Location
Cytogenetic map
92F10-92F10
Sequence location
3R:20,735,623..20,738,414 [+]
Recombination map

3-69

RefSeq locus
NT_033777 REGION:20735623..20738414
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (14 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables ATP binding
inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR002290, InterPro:IPR017441
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
enables cyclin binding
inferred from biological aspect of ancestor with PANTHER:PTN000623979
(assigned by GO_Central )
(Gaudet et al., 2011)
enables cyclin-dependent protein serine/threonine kinase activity
inferred from sequence or structural similarity with SGD:S000000364
(Lehner and O'Farrell, 1990)
inferred from biological aspect of ancestor with PANTHER:PTN000623091
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (8 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
involved_in positive regulation of receptor signaling pathway via JAK-STAT
inferred from physical interaction with FLYBASE:Stat92E; FB:FBgn0016917
(Chen et al., 2003)
Terms Based on Predictions or Assertions (7 terms)
CV Term
Evidence
References
involved_in G1/S transition of mitotic cell cycle
inferred from biological aspect of ancestor with PANTHER:PTN000623979
(assigned by GO_Central )
(Gaudet et al., 2011)
inferred from sequence or structural similarity with SGD:S000000364
(Lehner and O'Farrell, 1990)
involved_in G2/M transition of mitotic cell cycle
inferred from sequence or structural similarity with SGD:S000000364
(Lehner and O'Farrell, 1990)
involved_in positive regulation of cell population proliferation
inferred from biological aspect of ancestor with PANTHER:PTN000623979
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in protein phosphorylation
inferred from sequence or structural similarity with SGD:S000000364
(Lehner and O'Farrell, 1990)
inferred from biological aspect of ancestor with PANTHER:PTN000623091
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in regulation of G2/M transition of mitotic cell cycle
inferred from biological aspect of ancestor with PANTHER:PTN000623979
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in regulation of gene expression
inferred from biological aspect of ancestor with PANTHER:PTN000623979
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in signal transduction
inferred from biological aspect of ancestor with PANTHER:PTN000623979
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
part_of cyclin-dependent protein kinase holoenzyme complex
inferred from biological aspect of ancestor with PANTHER:PTN000623979
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN000623979
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000623091
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. (P23573)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
CYCLIN DEPENDENT KINASES -
Cyclin-dependent kinases (CDKs) are serine/threonine kinases whose activity depends on a regulatory cyclin subunit. (Adapted from PMID:25180339).
Pathway (FlyBase)
Positive Regulators of JAK-STAT Signaling Pathway -
Positive regulators of JAK-STAT signaling up-regulate the pathway, enhancing transcriptional control by Stat92E.
Protein Function (UniProtKB)
Like Cdk1, could play a key role in the control of the eukaryotic cell cycle.
(UniProt, P23573)
Summary (Interactive Fly)
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Cdk2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.50

Gene model reviewed during 5.43

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.47

Antisense UTR: 3' UTR overlaps CG17267 on opposite strand.

Gene model reviewed during 5.53

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Cdk2-RA
FBtr0083921
NM_169916
1140
314
Cdk2-RB
FBtr0083922
NM_079696
1215
314
Cdk2-RC
FBtr0300447
NM_001170195
2224
314
Additional Transcript Data and Comments
Reported size (kB)

1.1 (northern blot)

(Lehner and O'Farrell, 1990)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Cdk2-PA
FBpp0083329
35.9
314
8.44
NP_732544
AAN14363
Cdk2-PB
FBpp0083330
35.9
314
8.44
NP_524420
AAF55799
Cdk2-PC
FBpp0289675
35.9
314
8.44
NP_001163666
ACZ94962
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

314 aa isoforms: Cdk2-PA, Cdk2-PB, Cdk2-PC
Additional Polypeptide Data and Comments
Reported size (kDa)

314 (aa); 35.9 (kD)

(Lehner and O'Farrell, 1990)
Comments
External Data
Subunit Structure (UniProtKB)

Interacts with cyclin CycG.

(UniProt, P23573)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Cdk2 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism
(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 11 -- 12
central brain primordium
(Fisher et al., 2012)
embryonic central brain neuron
(Fisher et al., 2012)
embryonic neuroblast of ventral nerve cord primordium
(Fisher et al., 2012)
foregut primordium
(Fisher et al., 2012)
hindgut proper primordium
(Fisher et al., 2012)
lateral cord neuron
(Fisher et al., 2012)
Malpighian tubule primordium
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
procephalic neuroblast
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
embryonic hindgut
(Fisher et al., 2012)
embryonic Malpighian tubule
(Fisher et al., 2012)
embryonic/larval midgut
(Fisher et al., 2012)
embryonic/larval nervous system
(Fisher et al., 2012)
ventral nerve cord
(Fisher et al., 2012)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
presumptive embryonic/larval central nervous system
(Lehner and O'Farrell, 1990)
embryonic stage 1 -- 2
organism
(Lehner and O'Farrell, 1990)
Additional Descriptive Data

cdc2c expression correlates temporally and spatially with cell proliferation in embryos.

(Lehner and O'Farrell, 1990)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Cdk2 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 6 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 21 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Cdk2
Transgenic constructs containing regulatory region of Cdk2
Deletions and Duplications ( 6 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (12)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\CDK2
11 of 15
Yes
Yes
1  
Hsap\CDK3
7 of 15
No
Yes
Hsap\CDK1
4 of 15
No
No
Hsap\CDK5
4 of 15
No
No
2  
Hsap\CDK14
3 of 15
No
No
Hsap\CDK15
3 of 15
No
No
Hsap\CDK16
3 of 15
No
No
Hsap\CDK17
3 of 15
No
No
Hsap\CDK18
3 of 15
No
No
Hsap\CDK4
1 of 15
No
No
1  
Hsap\CDK6
1 of 15
No
No
1  
Hsap\COL4A5
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (12)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Cdk2
11 of 15
Yes
Yes
Mmus\Cdk1
5 of 15
No
No
Mmus\Cdk5
4 of 15
No
No
Mmus\Cdk3
3 of 15
No
Yes
Mmus\Cdk14
3 of 15
No
No
Mmus\Cdk16
3 of 15
No
No
Mmus\Cdk17
3 of 15
No
No
Mmus\Cdk18
3 of 15
No
No
Mmus\Cdk15
2 of 15
No
No
Mmus\Cdk4
1 of 15
No
No
Mmus\Cdk6
1 of 15
No
No
Mmus\E030030I06Rik
1 of 15
No
No
Rattus norvegicus (Norway rat) (10)
Rnor\Cdk2
8 of 13
Yes
Yes
Rnor\Cdk1
4 of 13
No
No
Rnor\Cdk5
3 of 13
No
No
Rnor\Cdk14
3 of 13
No
No
Rnor\Cdk16
3 of 13
No
No
Rnor\Cdk17
3 of 13
No
No
Rnor\Cdk18
3 of 13
No
No
Rnor\Cdk15
2 of 13
No
No
Rnor\Cdk4
1 of 13
No
No
Rnor\Cdk6
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (10)
Xtro\cdk2
9 of 12
Yes
Yes
Xtro\cdk1
3 of 12
No
No
Xtro\cdk14
3 of 12
No
No
Xtro\cdk15
3 of 12
No
No
Xtro\cdk16
3 of 12
No
Yes
Xtro\cdk17
3 of 12
No
No
Xtro\cdk18
3 of 12
No
No
Xtro\cdk5
2 of 12
No
No
Xtro\cdk4
1 of 12
No
No
Xtro\cdk6
1 of 12
No
No
Danio rerio (Zebrafish) (12)
Drer\cdk2
10 of 15
Yes
Yes
Drer\cdk1
4 of 15
No
No
Drer\cdk5
4 of 15
No
No
Drer\cdk14
3 of 15
No
No
Drer\cdk15
3 of 15
No
No
Drer\cdk16
3 of 15
No
No
Drer\cdk17
3 of 15
No
No
Drer\LOC100536316
3 of 15
No
Yes
Drer\si:dkey-166c18.1
3 of 15
No
No
Drer\cdk4
1 of 15
No
No
Drer\cdk6
1 of 15
No
No
Drer\cdk21
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (6)
Cele\cdk-1
4 of 15
Yes
No
Cele\cdk-2
4 of 15
Yes
Yes
Cele\cdk-5
4 of 15
Yes
No
Cele\pct-1
3 of 15
No
No
Cele\ZC123.4
2 of 15
No
No
Cele\cdk-4
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (5)
Atha\CDC2
5 of 9
Yes
No
Atha\CDKB1;1
1 of 9
No
Yes
Atha\CDKB1;2
1 of 9
No
No
Atha\CDKB2;1
1 of 9
No
Yes
Atha\CDKB2;2
1 of 9
No
No
Saccharomyces cerevisiae (Brewer's yeast) (5)
Scer\CDC28
9 of 15
Yes
Yes
Scer\PHO85
6 of 15
No
No
Scer\CAK1
2 of 15
No
Yes
Scer\CTK1
1 of 15
No
No
Scer\KDX1
1 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (5)
Spom\cdc2
7 of 12
Yes
Yes
Spom\pef1
4 of 12
No
No
Spom\lsk1
1 of 12
No
No
Spom\ppk23
1 of 12
No
No
Spom\srb10
1 of 12
No
No
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190BWU )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila simulans
Dsim\GD19371
Drosophila sechellia
Dsec\GM23132
Drosophila erecta
Dere\GG24088
Drosophila yakuba
Dyak\cdc2c
Drosophila ananassae
Dana\GF16690
Drosophila pseudoobscura pseudoobscura
Dpse\GA10356
Drosophila persimilis
Dper\GL27348
Drosophila willistoni
Dwil\GK22466
Drosophila virilis
Dvir\GJ25993
Drosophila mojavensis
Dmoj\GI10591
Drosophila grimshawi
Dgri\GH17244
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091508UE )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17026798
Musca domestica
House fly
Mdoa\17024677
Glossina morsitans
Tsetse fly
Gmor\GMOY008507
Glossina morsitans
Tsetse fly
Gmor\GMOY008110
Glossina morsitans
Tsetse fly
Gmor\GMOY010352
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_03798
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_03158
Mayetiola destructor
Hessian fly
Mdes\Mdes001323
Mayetiola destructor
Hessian fly
Mdes\Mdes012668
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL012339
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL013329
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL008621
Anopheles darlingi
American malaria mosquito
Adar\ADAC009114
Anopheles darlingi
American malaria mosquito
Adar\ADAC001696
Anopheles gambiae
Malaria mosquito
Agam\AGAP004579
Anopheles gambiae
Malaria mosquito
Agam\AGAP009459
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ011080
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ001155
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W09O5 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA013453
Bombyx mori
Silkmoth
Bmor\BGIBMGA013134
Danaus plexippus
Monarch butterfly
Dple\DPOGS210561-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS212741-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL009554
Heliconius melpomene
Postman butterfly
Hmel\HMEL016630
Heliconius melpomene
Postman butterfly
Hmel\HMEL008315
Apis florea
Little honeybee
Aflo\2266163556
Apis florea
Little honeybee
Aflo\2680259556
Apis mellifera
Western honey bee
Amel\cdc2c
Apis mellifera
Western honey bee
Amel\LOC409590
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP14897
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP23771
Bombus terrestris
Buff-tailed bumblebee
Bter\15205782
Bombus terrestris
Buff-tailed bumblebee
Bter\15204004
Linepithema humile
Argentine ant
Lhum\LH16408
Linepithema humile
Argentine ant
Lhum\LH17174
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0014ae
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000a32
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG004086
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG008313
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_07122
Tribolium castaneum
Red flour beetle
Tcas\TC011046
Tribolium castaneum
Red flour beetle
Tcas\GLEAN_15375-OG15232
Pediculus humanus
Human body louse
Phum\PHUM190130
Pediculus humanus
Human body louse
Phum\PHUM448370
Rhodnius prolixus
Kissing bug
Rpro\RPRC009342
Cimex lectularius
Bed bug
Clec\CLEC012796
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI009520
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI009520
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI003629
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI009520
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_05473
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_10296
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X09KB )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR005940
Strigamia maritima
European centipede
Smar\SMAR006988
Ixodes scapularis
Black-legged tick
Isca\ISCW019950
Ixodes scapularis
Black-legged tick
Isca\ISCW014734
Stegodyphus mimosarum
African social velvet spider
Smim\KFM79387.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM64822.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur06g06480
Tetranychus urticae
Two-spotted spider mite
Turt\tetur19g01640
Tetranychus urticae
Two-spotted spider mite
Turt\tetur19g01650
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_299546
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_299469
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0CH0 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Cdk1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Pctaire
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Cdk2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Cdk5
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_001227gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Pftaire-1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Cdk2_1
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000006693
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000005978
Ciona intestinalis
Vase tunicate
Cint\LOC100182544
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000009174
Gallus gallus
Domestic chicken
Ggal\CDK17
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000027196
Gallus gallus
Domestic chicken
Ggal\CDK14
Gallus gallus
Domestic chicken
Ggal\CDK15
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000028442
Gallus gallus
Domestic chicken
Ggal\CDC2
Gallus gallus
Domestic chicken
Ggal\CDK3
Gallus gallus
Domestic chicken
Ggal\CDK18
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (14)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Cdk1
7 of 10
Cdk5
6 of 10
Eip63E
5 of 10
Cdk4
3 of 10
Cdc2rk
2 of 10
Cdk7
2 of 10
Cdk8
2 of 10
Cdk9
2 of 10
Cdk12
2 of 10
CG6800
2 of 10
CG7236
2 of 10
Pitslre
2 of 10
Pk34A
2 of 10
Prp4k
2 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    CDK2; cyclin dependent kinase 2
    11 of 15
    116953
         
        CDK3; cyclin dependent kinase 3
        7 of 15
        123828
            CDK1; cyclin dependent kinase 1
            4 of 15
            116940
                CDK5; cyclin dependent kinase 5
                4 of 15
                123831
                   
                  CDK14; cyclin dependent kinase 14
                  3 of 15
                  610679
                      CDK15; cyclin dependent kinase 15
                      3 of 15
                      616147
                          CDK16; cyclin dependent kinase 16
                          3 of 15
                          311550
                              CDK17; cyclin dependent kinase 17
                              3 of 15
                              603440
                                  CDK18; cyclin dependent kinase 18
                                  3 of 15
                                  169190
                                      Functional Complementation Data
                                      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                                      Interactions
                                      Summary of Physical Interactions
                                      Summary of Genetic Interactions
                                      esyN Network Diagram
                                      esyN Network Key:
                                      Suppression
                                      Enhancement
                                      View in Interactions Browser
                                      Please look at the allele data for full details of the genetic interactions
                                      Starting gene(s)
                                      Interaction type
                                      Interacting gene(s)
                                      Reference
                                      Cdk2
                                      enhanceable
                                      rl
                                      (Park et al., 2017)
                                      Starting gene(s)
                                      Interaction type
                                      Interacting gene(s)
                                      Reference
                                      CycE
                                      suppressible
                                      Cdk2
                                      (Lane et al., 2000)
                                      CycE
                                      enhanceable
                                      Cdk2
                                      (Secombe et al., 1998)
                                      rl
                                      enhanceable
                                      Cdk2
                                      (Park et al., 2017)
                                      shot
                                      suppressible
                                      Cdk2
                                      (Sun et al., 2019)
                                      Snr1
                                      suppressible
                                      Cdk2
                                      (Zraly et al., 2004)
                                      External Data
                                      Subunit Structure (UniProtKB)
                                      Interacts with cyclin CycG.
                                      (UniProt, P23573 )
                                      Linkouts
                                      BioGRID - A database of protein and genetic interactions.
                                      DroID - A comprehensive database of gene and protein interactions.
                                      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                                      MIST (genetic) - An integrated Molecular Interaction Database
                                      MIST (protein-protein) - An integrated Molecular Interaction Database
                                      Pathways
                                      Genomic Location and Detailed Mapping Data
                                      Chromosome (arm)
                                      3R
                                      Recombination map

                                      3-69

                                      Cytogenetic map
                                      92F10-92F10
                                      Sequence location
                                      3R:20,735,623..20,738,414 [+]
                                      FlyBase Computed Cytological Location
                                      Cytogenetic map
                                      Evidence for location
                                      92F10-92F10
                                      Limits computationally determined from genome sequence between P{PZ}l(3)1058510585 and P{EP}SyndEP409
                                      Experimentally Determined Cytological Location
                                      Cytogenetic map
                                      Notes
                                      References
                                      Experimentally Determined Recombination Data
                                      Location

                                      3-69

                                      (FlyBase, 2016)

                                      3-72.9

                                      (Comeron et al., 2012)
                                      Left of (cM)
                                      Right of (cM)
                                      Notes
                                      Stocks and Reagents
                                      Stocks (13)
                                      Genomic Clones (13)
                                       

                                      Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                                      cDNA Clones (54)
                                       

                                      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                                      cDNA clones, fully sequenced
                                      BDGP DGC clones
                                      Other clones
                                      Drosophila Genomics Resource Center cDNA clones

                                      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                                      cDNA Clones, End Sequenced (ESTs)
                                      BDGP DGC clones
                                      Other clones
                                      RNAi and Array Information
                                      Linkouts
                                      DRSC - Results frm RNAi screens
                                      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                                      Antibody Information
                                      Laboratory Generated Antibodies
                                       

                                      polyclonal

                                      (Hughes et al., 2008, Lehner and O'Farrell, 1990)
                                      Commercially Available Antibodies
                                       
                                      Other Information
                                      Relationship to Other Genes
                                      Source for database identify of

                                      Source for identity of: cdc2c CG10498

                                      (Li, 1999.11)

                                      Source for identity of: Cdk2 cdc2c

                                      (FlyBase, 2009-)
                                      Source for database merge of
                                      Additional comments

                                      'cdc2c' renamed to 'Cdk2' owing to: i) preferred usage in the literature; ii) better indication of function/orthology; and iii) preference of authors Lehner and O'Farrell who originally characterized and named the gene in FBrf0051651.

                                      (FlyBase, 2009-)

                                      mir-995 is located within an intron of cdc2c.

                                      (Stark et al., 2007)
                                      Other Comments

                                      When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, an increase in the proportion of G1 phase cells, and increase in cell size, a decrease in the mitotic index, and cytokinetic index are seen.

                                      (Bettencourt-Dias et al., 2004)

                                      RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.

                                      (Boutros et al., 2004)

                                      RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.

                                      (Boutros et al., 2004)

                                      dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

                                      (Kiger et al., 2003)

                                      During mitotic cycles CycE and cdc2c kinase activity are present throughout the cell cycle. Reinitiation of DNA replication during the G2 phase of the mitotic cell cycle, therefore, is prevented by CycE/cdc2c kinase-independent regulation. Observations in CycA mutants implicate G2 cyclins in this regulation.

                                      (Sauer et al., 1995)

                                      Yeast interaction mating has been used to characterise Cyclin-dependent kinase interactor proteins (the prey) in hunts with either cdc2 or cdc2c as baits.

                                      (Finley and Brent, 1994)

                                      cdc2c kinase specifically associates with CycE in vivo.

                                      (Knoblich et al., 1994)

                                      cdc2c cannot compensate for lack of cdc2 function, indicating the independence of their action.

                                      (Stern et al., 1993)

                                      Northern blot and in situ hybridization studies demonstrate that cdc2 and cdc2c are coexpressed during embryogenesis. cdc2c expression is correlated with cell proliferation.

                                      (Lehner and O'Farrell, 1990)
                                      Origin and Etymology
                                      Discoverer
                                      Etymology
                                      Identification
                                      External Crossreferences and Linkouts ( 58 )
                                      Sequence Crossreferences
                                      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                                      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                                      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                                      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                                      UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                                      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                                      Other crossreferences
                                      BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                                      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                                      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                                      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                                      Flygut - An atlas of the Drosophila adult midgut
                                      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                                      iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                                      InterPro - A database of protein families, domains and functional sites
                                      KEGG Genes - Molecular building blocks of life in the genomic space.
                                      modMine - A data warehouse for the modENCODE project
                                      SignaLink - A signaling pathway resource with multi-layered regulatory networks.
                                      Linkouts
                                      BioGRID - A database of protein and genetic interactions.
                                      DPiM - Drosophila Protein interaction map
                                      DroID - A comprehensive database of gene and protein interactions.
                                      DRSC - Results frm RNAi screens
                                      FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                                      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                                      FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                                      FlyMine - An integrated database for Drosophila genomics
                                      Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                                      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                                      KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
                                      MIST (genetic) - An integrated Molecular Interaction Database
                                      MIST (protein-protein) - An integrated Molecular Interaction Database
                                      Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                                      Synonyms and Secondary IDs (18)
                                      Reported As
                                      Symbol Synonym
                                      CDC2C
                                      (Wagner et al., 2007)
                                      CDC2c
                                      (Finley and Brent, 1993)
                                      CDK2
                                      (Kanao et al., 2012, Faradji et al., 2011, Farkas et al., 2009, Bakal et al., 2008, Hughes et al., 2008, Reynolds et al., 2006, Calvi et al., 2005, Claycomb and Orr-Weaver, 2005, Thomer et al., 2004, Tower, 2004, Zraly et al., 2004, Rascle et al., 2003, Larochelle et al., 2001, Coelho and Leevers, 2000)
                                      CDK2/CDC2c
                                      (Morrison et al., 2000)
                                      CG10498
                                      (Çiçek et al., 2016, Schertel et al., 2013, Ni et al., 2011.7.19, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Perkins et al., 2009, Hughes et al., 2008, Morrison et al., 2000)
                                      Cdc2c
                                      (Nie et al., 2009, Hughes et al., 2008, Rascle et al., 2003, Finley and Brent, 1994, Clegg et al., 1993)
                                      Cdk2
                                      (Fast et al., 2020, Hinnant et al., 2020, Hur et al., 2020, Port et al., 2020, Williams et al., 2020, Yildirim et al., 2019, Park et al., 2017, Transgenic RNAi Project members, 2017-, Barrios et al., 2015, Kohlmaier et al., 2015, Chen et al., 2014, Ishidate et al., 2014, Zhang et al., 2014, Bonke et al., 2013, Dui et al., 2013, Noatynska et al., 2013, Zhou and Luo, 2013, Ruggiero et al., 2012, Ghorbani et al., 2011, Guest et al., 2011, Read, 2011, Buttitta et al., 2010, Reddy et al., 2010, Althoff et al., 2009, Glavic et al., 2009, Narbonne-Reveau and Lilly, 2009, Wang and Kalderon, 2009, Rimkus et al., 2008, Sukhanova and Du, 2008, Zielke et al., 2008, Zielke et al., 2008, Garcia et al., 2007, Gawlinski et al., 2007, Wagner et al., 2007, Bjorklund et al., 2006, Khurana et al., 2006, Lilly et al., 2006, Maurange et al., 2006, Swan et al., 2005, Emmerich et al., 2004, Hong and Lilly, 2004, Lewis et al., 2004, Lin et al., 2004, Secombe et al., 2004, Sherr and Roberts, 2004, Thomer et al., 2004, Chen et al., 2003, Chen et al., 2003, Jacobs et al., 2003, Reis and Edgar, 2003, Silver and Montell, 2003, Zhong et al., 2003, Johnston and Gallant, 2002, Vodermaier and Peters, 2002, Edgar and Orr-Weaver, 2001, Tin Su, 2001, Datar et al., 2000, Fujioka et al., 2000, Hong et al., 2000, Kolonin and Finley, 2000, Lane et al., 2000, Lis et al., 2000, Meyer et al., 2000, Foley and Sprenger, 1999, Foley et al., 1999, Harper and Elledge, 1998, Jacobs et al., 1998, Kolonin and Finley, 1998, Larochelle et al., 1998, Zavitz and Zipursky, 1997)
                                      Dcdc2c
                                      (Sugaya et al., 1994)
                                      DmCdc2c
                                      (Kolonin and Finley, 1997)
                                      DmCdk2
                                      (Kolonin and Finley, 1998)
                                      Dmcdc2c
                                      (Sauer et al., 1995, Knoblich et al., 1994, Foe et al., 1993, Pines and Hunter, 1991)
                                      S(Sev-CycE)3A
                                      (Lane et al., 2000)
                                      cdc2c
                                      (Dequéant et al., 2015, Wang and Baker, 2015, Chen et al., 2014, Sopko et al., 2014, Bonke et al., 2013, Neumüller et al., 2013, Schertel et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Korenjak et al., 2012, Friedman et al., 2011, Friedman et al., 2011, Friedman et al., 2011, Swaminathan et al., 2010, Fisher et al., 2008, Somma et al., 2008, Minidorff et al., 2007, Stark et al., 2007, Bowler et al., 2006, Foglietti et al., 2006, Morris et al., 2006, Stanyon et al., 2004)
                                      cdk2
                                      (Lee et al., 2019, Powell et al., 2015, Ruggiero et al., 2012, Szuplewski et al., 2009, Gupta et al., 2008, Buttitta et al., 2007, Morris et al., 2006, Kramer and Hawley, 2005, Coffman, 2004, Diffley, 2004, Asha et al., 2003, Frolov et al., 2003, Frolov et al., 2003, Park et al., 2003, Price et al., 2002, Murphy et al., 2001, Tapon et al., 2001, Duronio, 1999, Lane et al., 1996)
                                      dCdk2
                                      (Read et al., 2009)
                                      Name Synonyms
                                      Cyclin E
                                      (Kim and Jho, 2018, Guest et al., 2011)
                                      Cyclin-dependent kinase 2
                                      (Dequéant et al., 2015)
                                      cdc2c
                                      (Somma et al., 2008)
                                      cyclin-dependent kinase 2
                                      (Park et al., 2017, Rimkus et al., 2008)
                                      Secondary FlyBase IDs
                                        Datasets (0)
                                        Study focus (0)
                                        Experimental Role
                                        Project
                                        Project Type
                                        Title
                                        References (209)