General Information
Symbol
Dmel\tin
Species
D. melanogaster
Name
tinman
Annotation Symbol
CG7895
Feature Type
FlyBase ID
FBgn0004110
Gene Model Status
Stock Availability
Gene Snapshot
Tinman is a homeodomain transcription factor that is involved in the formation of the heart and dorsal vascular musculature. [Date last reviewed: 2016-06-23]
Also Known As
NK-4, msh-2, NK4/msh-2, msh2, NK4
Genomic Location
Cytogenetic map
Sequence location
3R:21,378,977..21,381,970 [+]
Recombination map
3-71
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
GO Summary Ribbons
Families, Domains and Molecular Function
Gene Group Membership (FlyBase)
Protein Family (UniProt, Sequence Similarities)
-
Molecular Function (see GO section for details)
Summaries
Gene Group Membership
NK-LIKE HOMEOBOX TRANSCRIPTION FACTORS -
NK-like (NKL) homeobox transcription factors are sequence-specific DNA binding proteins that regulate transcription. NKL transcription factors are homeobox genes closely related to Hox-like genes, a number of which are found in the NK cluster. Many of the NKL members contain an Engrailed Homology 1 (EH1) motif. (Adapted from FBrf0232555 and PMID:22094586).
UniProt Contributed Function Data
Required for the development of heart and visceral muscle; for the formation of somatic muscles. Has a crucial function in the early mesodermal subdivisions.
(UniProt, P22711)
Phenotypic Description from the Red Book (Lindsley and Zimm 1992)
NK4 (M. Nirenberg)
The NK4 homeobox gene is first expressed in 3-hour embryos; no NK4 mRNA is detected in embryos at earlier stages of development. NK4 mRNA is detected only in mesodermal cells. The transcripts are most abundant in 3-9-hour embryos; the mRNA decreases in abundance thereafter.
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\tin or the JBrowse view of Dmel\tin for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.49
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0084086
1664
416
Additional Transcript Data and Comments
Reported size (kB)
1.8 (northern blot)
1.7 (northern blot)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0083485
46.1
416
8.42
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\tin using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (28 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (0 terms)
Biological Process (24 terms)
Terms Based on Experimental Evidence (15 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from expression pattern
inferred from expression pattern
inferred from direct assay
inferred from mutant phenotype
inferred from mutant phenotype
inferred from high throughput mutant phenotype
Terms Based on Predictions or Assertions (12 terms)
CV Term
Evidence
References
Cellular Component (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
inferred from direct assay
Terms Based on Predictions or Assertions (0 terms)
Expression Data
Transcript Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
tin and eya are coexpressed in the entire mesoderm at embryonic stage 8 and 9. By stage 10, tin expression is restricted to the dorsal mesoderm while eya expression is restricted to the dorsal mesoderm.
tin is first expressed between 2 and 4 hours of embryogenesis, peaks between 4 and 8 hours and decreases dramatically in late embryogenesis. It is not expressed postembryonically. tin is first expressed in the cellular blastoderm embryo in the ventral-most region of the embryo. After invagination of the ventral-most cells, tin mRNA is found exclusively in the mesoderm. During stage 9, tin expression is reduced in some mesodermal cells and by stage 10, tin expression is restricted to 6-8 cells on either side in the dorsal-most reigons of the mesoderm. During stage 11, each tin-expressing region splits into two separate domains. One corresponds to part of the visceral mesoderm and the other to cells at the dorsal tip of the mesoderm that include the precursors to the heart. tin expression continues in heart progenitors until late stages of embryogenesis when they differentiate into the dorsal blood vessel.
tin transcripts are expressed predominantly between 3 and 9 hours of embryogenesis and are present at low levels between 9 and 12 hours. They are first expressed along the ventral longitudinal axis in the late blastoderm just prior to the ventral invagination of the mesoderm. The strip of tin-expressing cells is about 14-16 cells wide. After gastrulation, tin is expressed in the mesoderm. At about 4.5 hours, the mesodermal mass starts to spread dorsally. As the cell layer reaches the dorsal margin, ventrally located mesodermal cells cease tin expression. The dorsally located cells which are the primordia for the visceral musculature express tin for another 1-2 hours. In stage 11, tin expression in the dorsal mesoderm is reduced to patches of cells. tin expression is also seen in the cephalic region at ~stage 10-11 surrounding the stomodeum. In stage 11, a row of cells at the dorsal margin begins expressing tin. These cells which correspond to heart primordia, are the only ones that continue to express tin after the germ band extended stage.
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
tin protein is expressed in cardial, but not pericardial, cells in third instar larvae.
tin protein is observed in the cephalic vascular rudiment, a group of cells surrounding the migrating corpus cardiacum precursor cells, and that represent an evolutionary vestige of the cephalic aorta.
Expression of tin protein is observed in four pairs of cardioblasts per thoracic hemisegment, and in the posterior-most four pairs of cardioblasts per abdominal hemisegment.
Four pairs of tin-positive nuclei are seen in the larval heart but none are in the region of the ostia.
tin protein is detected in the trunk mesoderm at stage 8-9, the dorsal mesoderm at stage 10, and the cardiac and visceral mesoderm at stage 11-12. After stage 14, expression is restricted to the developing heart. In stage 15-16 embryos, expression is detected in the myocardial and pericardial cells of the heart tube, with only 4 out of 6 cells per hemisegment expressing tin protein.
Marker for
Subcellular Localization
CV Term
Evidence
References
inferred from direct assay
Expression Deduced from Reporters
Reporter: P{IIA237-lacZ}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{tinC-Gal4.Δ4}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{tin-Gal4.B}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{tin-GFP.C}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{tin-lacZ.2A}
Stage
Tissue/Position (including subcellular localization)
Reference
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{tin-lacZ.D}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{tin-lacZ.P1}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{tin-lacZ.P1E1m}
Stage
Tissue/Position (including subcellular localization)
Reference
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{tin-lacZ.P1E2m}
Stage
Tissue/Position (including subcellular localization)
Reference
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\tin in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
Alleles, Insertions, Transgenic Constructs and Phenotypes
Classical and Insertion Alleles ( 28 )
Transgenic Constructs ( 31 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of tin
Allele of tin
Mutagen
Associated Transgenic Construct
Stocks
Transgenic constructs containing regulatory region of tin
characterization construct
Name
Expression Data
GAL4 construct
Name
Expression Data
vital-reporter construct
Name
Expression Data
Deletions and Duplications ( 11 )
Summary of Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
embryonic/larval fat body & parasegment 3
embryonic/larval fat body & parasegment 13
embryonic/larval heart & mesoderm
gonad & parasegment 10
gonad & parasegment 11
gonad & parasegment 12
myofibril & adult dorsal vessel, with tinEC40/tin346
myofibril & adult dorsal vessel (with tin346), with tinABD
myofibril & adult dorsal vessel (with tinEC40), with tinABD
myofibril & larval dorsal vessel, with tinEC40/tin346
myofibril & larval dorsal vessel (with tin346), with tinABD
myofibril & larval dorsal vessel (with tinEC40), with tinABD
myofibril & larval heart, with tinEC40/tin346
myofibril & larval heart (with tin346), with tinABD
myofibril & larval heart (with tinEC40), with tinABD
transverse nerve & dorsal mesothoracic disc
transverse nerve & dorsal metathoracic disc
transverse nerve & dorsal prothoracic disc
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (11)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
3 of 15
Yes
No
3 of 15
Yes
Yes
3 of 15
Yes
Yes
3 of 15
Yes
Yes
3 of 15
Yes
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (11)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
5 of 15
Yes
Yes
4 of 15
No
Yes
 
 
3 of 15
No
No
3 of 15
No
Yes
3 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Rattus norvegicus (Norway rat) (10)
4 of 13
Yes
Yes
3 of 13
No
Yes
3 of 13
No
No
2 of 13
No
No
2 of 13
No
No
1 of 13
No
Yes
1 of 13
No
Yes
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (10)
3 of 12
Yes
Yes
3 of 12
Yes
Yes
3 of 12
Yes
Yes
2 of 12
No
No
2 of 12
No
No
2 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
Danio rerio (Zebrafish) (17)
5 of 15
Yes
Yes
4 of 15
No
Yes
3 of 15
No
Yes
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (9)
2 of 15
Yes
No
2 of 15
Yes
Yes
2 of 15
Yes
No
1 of 15
No
No
 
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (18)
2 of 9
Yes
Yes
2 of 9
Yes
Yes
2 of 9
Yes
Yes
2 of 9
Yes
Yes
1 of 9
No
Yes
1 of 9
No
Yes
1 of 9
No
No
1 of 9
No
Yes
1 of 9
No
Yes
1 of 9
No
Yes
1 of 9
No
No
1 of 9
No
No
1 of 9
No
Yes
1 of 9
No
No
1 of 9
No
No
1 of 9
No
No
1 of 9
No
Yes
1 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (0)
No orthologs reported.
Schizosaccharomyces pombe (Fission yeast) (0)
No orthologs reported.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG09190B29 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091506T4 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0DQS )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0DOS )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Stegodyphus mimosarum
African social velvet spider
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
No non-Arthropod Metazoa orthologies identified
Human Disease Model Data
FlyBase Human Disease Model Reports
    Alleles Reported to Model Human Disease (Disease Ontology)
    Download
    Models ( 0 )
    Allele
    Disease
    Evidence
    References
    Interactions ( 0 )
    Allele
    Disease
    Interaction
    References
    Comments ( 0 )
     
    Human Orthologs (via DIOPT v7.1)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Dmel gene
    Ortholog showing functional complementation
    Supporting References
    Interactions
    Summary of Physical Interactions
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement

    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    Pathways
    Gene Group - Pathway Membership (FlyBase)
    External Data
    Linkouts
    SignaLink - A signaling pathway resource with multi-layered regulatory networks.
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3R
    Recombination map
    3-71
    Cytogenetic map
    Sequence location
    3R:21,378,977..21,381,970 [+]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    93D9-93D9
    Limits computationally determined from genome sequence between P{PZ}mod(mdg4)07038&P{lacW}mod(mdg4)L3101 and P{PZ}InR05545
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    93E1-93E3
    93E1-93E3
    (determined by in situ hybridisation)
    Experimentally Determined Recombination Data
    Location
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (11)
    Genomic Clones (15)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (138)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequences
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    BDGP DGC clones
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Antibody Information
    Laboratory Generated Antibodies
    Commercially Available Antibodies
     
    Other Information
    Relationship to Other Genes
    Source for database identify of
    Source for database merge of
    Additional comments
    May be allelic to l(3)93Dg.
    Other Comments
    DNA-protein interactions: genome-wide binding profile assayed for tin protein in stage 9-11 embryos; ArrayExpress accession number E-MTAB-1184.
    tin is required in cardioblasts for the normal diversification of cardial cells and the proper differentiation of the four tin+ cardioblast pairs within each segment.
    tin is required for the development of all cardiogenic mesoderm.
    tin expression is controlled by the convergence of dpp, bnl, wg and N signalling.
    pnr is a direct transcriptional target of tin in the heart-forming region.
    tin protein interacts directly with the gro corepressor protein, for which the homeodomain is required.
    tin has an essential role in activation of Mef2 transcription in multiple myogenic lineages.
    tin is not required for early zfh1 expression throughout the mesoderm or for the refinement of this expression to lateral mesodermal clusters during stage 10. tin activity is required for aspects of zfh1 expression beginning at stage 11. tin and zfh1 cooperate in the specification of two tissues derived from the lateral mesoderm: the gonadal mesoderm and the fat body.
    Mutants are isolated in an EMS mutagenesis screen to identify zygotic mutations affecting germ cell migration at discrete points during embryogenesis: mutants exhibit germ cell migration defects.
    tin is required for the development of both fat body and gonadal mesoderm in the embryo.
    While tin and Mmus\Nkx2-5 show close functional kinship, their mode of deployment in cardiogenesis has diverged possibly because of differences in their interactions with accessory factors. The distinct cardiogenic programs in vertebrates and flies may be built upon a common and perhaps more ancient program for the specification of visceral muscle.
    tin is involved in the regionalisation of the dorsolateral mesoderm by the homeotic genes. There is a balance between fat body and somatic gonadal precursor (SGP) development with tin, wg and en driving cells in the primary clusters towards SGP development and srp driving them towards fat body development.
    An upstream enhancer containing two tin binding sites is required for Mef2 expression in the developing heart.
    Two distinct clusters of E-box regulatory sequences, present upstream of tin, mediate tin expression in the visceral mesoderm. These elements are conserved between tin and Dvir\tin and serve as binding sites for twi (E1 cluster) and tin (E2 cluster). Results demonstrate tin is a direct transcriptional target for twi and its own gene product in visceral mesodermal cells, supporting the idea that twi and tin function in the subdivision of the mesoderm during embryogenesis.
    tin is controlled by an array of discrete enhancer elements that are activated successively by differential genetic inputs, as well as by closely linked activator and repressor binding sites within an early-acting enhancer, which restricts twi activity to specific areas within the twi expression domain. Three of the four identified elements are conserved between D.melanogaster and D.virilis with respect to sequence, relative position and spatial/temporal activity. Overall orientation not stated: mod(mdg4)- tin+
    dpp is in the inductive signal from dorsal ectoderm cells to activate tin expression in underlying mesodermal cells. dpp mutants cause lack of visceral mesoderm and heart, ectopic expression of dpp results in ectopic formation of visceral mesoderm.
    An inductive signal from dorsal ectodermal cells is required for activation of tin in the underlying mesoderm. dpp serves as a signalling molecule in this process. The spatial expression of dpp in the ectoderm determines which cells of the mesoderm become competent to develop into visceral mesoderm and the heart.
    During embryogenesis, tin expression in the dorsalmost mesoderm depends on proximity to dpp-expressing dorsal ectoderm.
    wg-dependent signal appears to cooperate with tin to contribute to the patterning and subdivision of the early mesoderm which leads to the formation of cardiac mesoderm.
    The genomic region of tin contains several twi binding sites suggesting that twi is a direct activator of tin.
    tin expression in wg mutant embryos suggests that tin activity is required in the cardiac mesoderm itself, as opposed to being required in the early mesoderm or the visceral mesoderm for normal heart development to proceed.
    Observations of tin mutants suggest that transverse nerve exit glial cell are required for axon pathfinding in the embryo, and that these glia and the support cells of the dorsal neurohemal organs have a mesodermal origin.
    Unaltered Mef2 gene expression in tin mutant embryos suggests that Mef2 gene expression is not regulated by tin.
    Genetic analysis demonstrates that the tin gene product is required for the formation of visceral musculature, the specification of heart precursor cells and the normal development of body wall muscles from the dorsal mesoderm.
    The function of tin is required for visceral muscle and heart development, though somatic muscle development is largely unaffected in mutants.
    In mutant embryos lacking the entire mesoderm or failing to differentiate the visceral mesoderm, the anterior and posterior midgut primordia form but do not migrate properly.
    tin acts after the initial mesoderm induction downstream of twi and is likely to specify primordial cell fates of the heart and visceral muscles.
    tin has been cloned and characterised.
    The tin homeobox gene is first expressed in 3-hour embryos; no tin mRNA is detected in embryos at earlier stages of development. tin mRNA is detected only in mesodermal cells. The transcripts are most abundant in 3-9-hour embryos; the mRNA decreases in abundance thereafter.
    Origin and Etymology
    Discoverer
    Etymology
    Identification
    External Crossreferences and Linkouts ( 94 )
    Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
    Other crossreferences
    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
    InterPro - A database of protein families, domains and functional sites
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center cDNA clones
    DroID - A comprehensive database of gene and protein interactions.
    DRSC - Results frm RNAi screens
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    Flygut - An atlas of the Drosophila adult midgut
    FlyMine - An integrated database for Drosophila genomics
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    KEGG Genes - Molecular building blocks of life in the genomic space.
    modMine - A data warehouse for the modENCODE project
    SignaLink - A signaling pathway resource with multi-layered regulatory networks.
    Synonyms and Secondary IDs (19)
    Reported As
    Symbol Synonym
    tin
    (Schwarz et al., 2018, Koenecke et al., 2017, Mendoza-García et al., 2017, Transgenic RNAi Project members, 2017-, Bürglin and Affolter, 2016, Mbodj et al., 2016, Sandler and Stathopoulos, 2016, Bivik et al., 2015, Monfort and Furlong, 2015.1.15, Schertel et al., 2015, Goellner and Frasch, 2014.1.27, Haye et al., 2014, Jiang and Singh, 2014, Rembold et al., 2014, Tripathy et al., 2014, Hombría and Sotillos, 2013, Jin et al., 2013, Neckameyer and Argue, 2013, Ahmad et al., 2012, Amodio et al., 2012, Boukhatmi et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Steiner et al., 2012, White-Cooper, 2012, Xu et al., 2012, Bantignies et al., 2011, Doggett et al., 2011, Nègre et al., 2011, Park et al., 2011, Pruteanu-Malinici et al., 2011, Qian et al., 2011, Ryu et al., 2011, Salmand et al., 2011, Frise et al., 2010, Okumura et al., 2010, Hazelett et al., 2009, Kim and Wolf, 2009, Qian and Bodmer, 2009, Von Ohlen et al., 2009, DeFalco et al., 2008, Frise et al., 2008, Iklé et al., 2008, Qian et al., 2008, Rivas et al., 2008, Tögel et al., 2008, Zmojdzian et al., 2008, Aerts et al., 2007, Dietzl et al., 2007, Hendren et al., 2007, Johnson et al., 2007, Junion et al., 2007, Mann et al., 2007, Monier et al., 2007, Ryan et al., 2007, Taniguchi et al., 2007, Zeitlinger et al., 2007, Zeitouni et al., 2007, Akasaka et al., 2006, Akasaka et al., 2006, Albrecht et al., 2006, Clark et al., 2006, Davidson and Erwin, 2006, de Velasco et al., 2006, Lawrence, 2006, Sellin et al., 2006, Zaffran et al., 2006, Copley, 2005, Wang et al., 2005, Wawersik and Van, 2005, Zaffran and Frasch, 2005, Nguyen et al., 2002)
    Name Synonyms
    muscle-specific-homeodomain-2
    Secondary FlyBase IDs
    • FBgn0002850
    • FBgn0002944
    Datasets (1)
    Study focus (1)
    Experimental Role
    Project
    Project Type
    Title
    • bait_protein
    ChIP-chip identification of binding sites for transcription factors that regulate mesodermal development.
    References (489)