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Gene Dmel\boca

General Information
Symbol	Dmel\boca	Species	D. melanogaster
Name	boca	Annotation symbol	CG30498
Feature type	protein_coding_gene	FlyBase ID	FBgn0004132
Gene Model Status	Current	Stock availability	5 publicly available
Also Known As	CG1364, l(2)43Ea
Genomic Location
Chromosome (arm)	2R	Recombination map	2-[57]
Cytogenetic map	43D7-43D7	Sequence location	2R:3,453,378..3,454,243 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene boca is referred to in FlyBase by the symbol Dmel\boca (CG30498, FBgn0004132). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: ER to Golgi vesicle-mediated transport; proboscis development; low-density lipoprotein receptor particle metabolic process; oogenesis; Wnt receptor signaling pathway; protein targeting to membrane. 9 alleles are reported. The phenotypes of these alleles are annotated with: wing disc; proboscis. It has one annotated transcript and one annotated polypeptide. Protein features are: Mesoderm development candidate 2. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages, during early pupal stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1623599_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of boca. Gene sequence location is 2R:3453378..3454243.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 43D7-43D7   Limits computationally determined from genome sequence between P{EP}CG1600EP398 and P{PZ}scra03427&P{EP}EP2179
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location	2-[57]
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\boca for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.42 Gene model reviewed during 5.48
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) boca-RA FBtr0088953  NM_165541   704   180
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein boca-PA   FBpp0088027   21.0   180   4.53     NP_724578   AAF59229
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Mesoderm development candidate 2 (IPR019330)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE013599 AAF59229   AI542360   AW944564   AY069840 AAL39985   BI351827   BT044294   EL877866   EV587414   EV591881
UniProtKB/Swiss-Prot	Q8T9B6
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism | ubiquitous   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 13 -- 16   organism | ubiquitous   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
apical part of cell inferred from direct assay (Culi and Mann, 2003) cytoplasm inferred from direct assay (Culi and Mann, 2003) endoplasmic reticulum lumen inferred from direct assay (Culi and Mann, 2003)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    348.325 Larval Midgut    95.6 Larval Hindgut    190.1 Larval Malpighian Tubules    140.5 Larval Fat Body    277.4 Larval Salivary Gland    408.6 Larval Trachea    333.1 Larval Carcass    141.5 Adult Head    269.4 Adult Eye    288.425 Adult Brain    265.7 Adult Thoracic-Abdominal Ganglion    276.2 Adult Crop    262.1 Adult Midgut    95.1 Adult Hindgut    239.3 Adult Malpighian Tubules    195.8 Adult Fat Body    284.3 Adult Salivary Gland    320.3 Adult Heart    286.55 Adult VirginFemale Spermatheca    330.6 Adult InseminatedFemale Spermatheca    384 Adult Ovary    278.3 Adult Testis    33.6 Adult Male Accessory Gland    250.9 Adult Carcass    230 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    348.325 Larval Midgut    95.6 Larval Hindgut    190.1 Larval Malpighian Tubules    140.5 Larval Fat Body    277.4 Larval Salivary Gland    408.6 Larval Trachea    333.1 Larval Carcass    141.5 Adult Head    269.4 Adult Eye    288.425 Adult Brain    265.7 Adult Thoracic-Abdominal Ganglion    276.2 Adult Crop    262.1 Adult Midgut    95.1 Adult Hindgut    239.3 Adult Malpighian Tubules    195.8 Adult Fat Body    284.3 Adult Salivary Gland    320.3 Adult Heart    286.55 Adult VirginFemale Spermatheca    330.6 Adult InseminatedFemale Spermatheca    384 Adult Ovary    278.3 Adult Testis    33.6 Adult Male Accessory Gland    250.9 Adult Carcass    230 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    348.325 Larval Midgut    95.6 Larval Hindgut    190.1 Larval Malpighian Tubules    140.5 Larval Fat Body    277.4 Larval Salivary Gland    408.6 Larval Trachea    333.1 Larval Carcass    141.5 Adult Head    269.4 Adult Eye    288.425 Adult Brain    265.7 Adult Thoracic-Abdominal Ganglion    276.2 Adult Crop    262.1 Adult Midgut    95.1 Adult Hindgut    239.3 Adult Malpighian Tubules    195.8 Adult Fat Body    284.3 Adult Salivary Gland    320.3 Adult Heart    286.55 Adult VirginFemale Spermatheca    330.6 Adult InseminatedFemale Spermatheca    384 Adult Ovary    278.3 Adult Testis    33.6 Adult Male Accessory Gland    250.9 Adult Carcass    230 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    348.325 Larval Midgut    95.6 Larval Hindgut    190.1 Larval Malpighian Tubules    140.5 Larval Fat Body    277.4 Larval Salivary Gland    408.6 Larval Trachea    333.1 Larval Carcass    141.5 Adult Head    269.4 Adult Eye    288.425 Adult Brain    265.7 Adult Thoracic-Abdominal Ganglion    276.2 Adult Crop    262.1 Adult Midgut    95.1 Adult Hindgut    239.3 Adult Malpighian Tubules    195.8 Adult Fat Body    284.3 Adult Salivary Gland    320.3 Adult Heart    286.55 Adult VirginFemale Spermatheca    330.6 Adult InseminatedFemale Spermatheca    384 Adult Ovary    278.3 Adult Testis    33.6 Adult Male Accessory Gland    250.9 Adult Carcass    230 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    348.325 Larval Midgut    95.6 Larval Hindgut    190.1 Larval Malpighian Tubules    140.5 Larval Fat Body    277.4 Larval Salivary Gland    408.6 Larval Trachea    333.1 Larval Carcass    141.5 Adult Head    269.4 Adult Eye    288.425 Adult Brain    265.7 Adult Thoracic-Abdominal Ganglion    276.2 Adult Crop    262.1 Adult Midgut    95.1 Adult Hindgut    239.3 Adult Malpighian Tubules    195.8 Adult Fat Body    284.3 Adult Salivary Gland    320.3 Adult Heart    286.55 Adult VirginFemale Spermatheca    330.6 Adult InseminatedFemale Spermatheca    384 Adult Ovary    278.3 Adult Testis    33.6 Adult Male Accessory Gland    250.9 Adult Carcass    230 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    348.325 Larval Midgut    95.6 Larval Hindgut    190.1 Larval Malpighian Tubules    140.5 Larval Fat Body    277.4 Larval Salivary Gland    408.6 Larval Trachea    333.1 Larval Carcass    141.5 Adult Head    269.4 Adult Eye    288.425 Adult Brain    265.7 Adult Thoracic-Abdominal Ganglion    276.2 Adult Crop    262.1 Adult Midgut    95.1 Adult Hindgut    239.3 Adult Malpighian Tubules    195.8 Adult Fat Body    284.3 Adult Salivary Gland    320.3 Adult Heart    286.55 Adult VirginFemale Spermatheca    330.6 Adult InseminatedFemale Spermatheca    384 Adult Ovary    278.3 Adult Testis    33.6 Adult Male Accessory Gland    250.9 Adult Carcass    230 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    348.325 Larval Midgut    95.6 Larval Hindgut    190.1 Larval Malpighian Tubules    140.5 Larval Fat Body    277.4 Larval Salivary Gland    408.6 Larval Trachea    333.1 Larval Carcass    141.5 Adult Head    269.4 Adult Eye    288.425 Adult Brain    265.7 Adult Thoracic-Abdominal Ganglion    276.2 Adult Crop    262.1 Adult Midgut    95.1 Adult Hindgut    239.3 Adult Malpighian Tubules    195.8 Adult Fat Body    284.3 Adult Salivary Gland    320.3 Adult Heart    286.55 Adult VirginFemale Spermatheca    330.6 Adult InseminatedFemale Spermatheca    384 Adult Ovary    278.3 Adult Testis    33.6 Adult Male Accessory Gland    250.9 Adult Carcass    230 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    348.325 Larval Midgut    95.6 Larval Hindgut    190.1 Larval Malpighian Tubules    140.5 Larval Fat Body    277.4 Larval Salivary Gland    408.6 Larval Trachea    333.1 Larval Carcass    141.5 Adult Head    269.4 Adult Eye    288.425 Adult Brain    265.7 Adult Thoracic-Abdominal Ganglion    276.2 Adult Crop    262.1 Adult Midgut    95.1 Adult Hindgut    239.3 Adult Malpighian Tubules    195.8 Adult Fat Body    284.3 Adult Salivary Gland    320.3 Adult Heart    286.55 Adult VirginFemale Spermatheca    330.6 Adult InseminatedFemale Spermatheca    384 Adult Ovary    278.3 Adult Testis    33.6 Adult Male Accessory Gland    250.9 Adult Carcass    230 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    269.4   NA  Eye    288.425   NA  Brain    265.7   348.325  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    276.2   NA  Crop    262.1   95.6  Midgut    95.1   190.1  Hindgut    239.3   140.5  Malpighian Tubules    195.8   277.4  Fat Body    284.3   408.6  Salivary Gland    320.3   NA  Heart    286.55   333.1  Trachea    NA   NA  VirginFemale Spermatheca    330.6   NA  InseminatedFemale Spermatheca    384   NA  Ovary    278.3   NA  Testis    33.6   NA  Male Accessory Gland    250.9   141.5  Carcass    230 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    41 central nervous system, larvae L3    52 central nervous system, pupae P8    28 head, virgin 1-day female    23 head, virgin 4-day female    20 head, virgin 20-day female    18 head, mated 1-day female    20 head, mated 4-day female    15 head, mated 20-day female    19 head, mated 1-day male    16 head, mated 4-day male    21 head, mated 20-day male    28 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    12 digestive system, larvae L3 wandering    19 digestive system, 1-day adult    15 digestive system, 4-day adult    14 digestive system, 20-day adult    14 fat body, larvae L3 wandering    23 fat body, white prepupae    13 fat body, pupae P8    19 carcass, larvae L3 wandering    46 carcass, 1-day adult    15 carcass, 4-day adult    18 carcass, 20-day adult    18 ovary, virgin 4-day female    41 ovary, mated 4-day female    41 testis, mated 4-day male    22 accessory gland, mated 4-day male    22 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (41) central nervous system, larvae L3  (52) central nervous system, pupae P8  (28) head, virgin 1-day female    23 head, virgin 4-day female    20 head, virgin 20-day female    18 head, mated 1-day female    20 head, mated 4-day female    15 head, mated 20-day female    19 head, mated 1-day male    16 head, mated 4-day male    21 head, mated 20-day male  (28) salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    12 digestive system, larvae L3 wandering    19 digestive system, 1-day adult    15 digestive system, 4-day adult    14 digestive system, 20-day adult    14 fat body, larvae L3 wandering    23 fat body, white prepupae    13 fat body, pupae P8    19 carcass, larvae L3 wandering  (46) carcass, 1-day adult    15 carcass, 4-day adult    18 carcass, 20-day adult    18 ovary, virgin 4-day female  (41) ovary, mated 4-day female  (41) testis, mated 4-day male    22 accessory gland, mated 4-day male    22 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    41 central nervous system, larvae L3    52 central nervous system, pupae P8    28 head, virgin 1-day female    23 head, virgin 4-day female    20 head, virgin 20-day female    18 head, mated 1-day female    20 head, mated 4-day female    15 head, mated 20-day female    19 head, mated 1-day male    16 head, mated 4-day male    21 head, mated 20-day male    28 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    12 digestive system, larvae L3 wandering    19 digestive system, 1-day adult    15 digestive system, 4-day adult    14 digestive system, 20-day adult    14 fat body, larvae L3 wandering    23 fat body, white prepupae    13 fat body, pupae P8    19 carcass, larvae L3 wandering    46 carcass, 1-day adult    15 carcass, 4-day adult    18 carcass, 20-day adult    18 ovary, virgin 4-day female    41 ovary, mated 4-day female    41 testis, mated 4-day male    22 accessory gland, mated 4-day male    22 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    41 central nervous system, larvae L3    52 central nervous system, pupae P8    28 head, virgin 1-day female    23 head, virgin 4-day female    20 head, virgin 20-day female    18 head, mated 1-day female    20 head, mated 4-day female    15 head, mated 20-day female    19 head, mated 1-day male    16 head, mated 4-day male    21 head, mated 20-day male    28 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    12 digestive system, larvae L3 wandering    19 digestive system, 1-day adult    15 digestive system, 4-day adult    14 digestive system, 20-day adult    14 fat body, larvae L3 wandering    23 fat body, white prepupae    13 fat body, pupae P8    19 carcass, larvae L3 wandering    46 carcass, 1-day adult    15 carcass, 4-day adult    18 carcass, 20-day adult    18 ovary, virgin 4-day female    41 ovary, mated 4-day female    41 testis, mated 4-day male    22 accessory gland, mated 4-day male    22 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    41 central nervous system, larvae L3    52 central nervous system, pupae P8    28 head, virgin 1-day female    23 head, virgin 4-day female    20 head, virgin 20-day female    18 head, mated 1-day female    20 head, mated 4-day female    15 head, mated 20-day female    19 head, mated 1-day male    16 head, mated 4-day male    21 head, mated 20-day male    28 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    12 digestive system, larvae L3 wandering    19 digestive system, 1-day adult    15 digestive system, 4-day adult    14 digestive system, 20-day adult    14 fat body, larvae L3 wandering    23 fat body, white prepupae    13 fat body, pupae P8    19 carcass, larvae L3 wandering    46 carcass, 1-day adult    15 carcass, 4-day adult    18 carcass, 20-day adult    18 ovary, virgin 4-day female    41 ovary, mated 4-day female    41 testis, mated 4-day male    22 accessory gland, mated 4-day male    22 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (41) central nervous system, larvae L3  (52) central nervous system, pupae P8  28 head, virgin 1-day female    23 head, virgin 4-day female    20 head, virgin 20-day female    18 head, mated 1-day female    20 head, mated 4-day female    15 head, mated 20-day female    19 head, mated 1-day male    16 head, mated 4-day male    21 head, mated 20-day male  28 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    12 digestive system, larvae L3 wandering    19 digestive system, 1-day adult    15 digestive system, 4-day adult    14 digestive system, 20-day adult    14 fat body, larvae L3 wandering    23 fat body, white prepupae    13 fat body, pupae P8    19 carcass, larvae L3 wandering  (46) carcass, 1-day adult    15 carcass, 4-day adult    18 carcass, 20-day adult    18 ovary, virgin 4-day female  (41) ovary, mated 4-day female  (41) testis, mated 4-day male    22 accessory gland, mated 4-day male    22 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    41 central nervous system, larvae L3    52 central nervous system, pupae P8    28 head, virgin 1-day female    23 head, virgin 4-day female    20 head, virgin 20-day female    18 head, mated 1-day female    20 head, mated 4-day female    15 head, mated 20-day female    19 head, mated 1-day male    16 head, mated 4-day male    21 head, mated 20-day male    28 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    12 digestive system, larvae L3 wandering    19 digestive system, 1-day adult    15 digestive system, 4-day adult    14 digestive system, 20-day adult    14 fat body, larvae L3 wandering    23 fat body, white prepupae    13 fat body, pupae P8    19 carcass, larvae L3 wandering    46 carcass, 1-day adult    15 carcass, 4-day adult    18 carcass, 20-day adult    18 ovary, virgin 4-day female    41 ovary, mated 4-day female    41 testis, mated 4-day male    22 accessory gland, mated 4-day male    22 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    41 central nervous system, larvae L3    52 central nervous system, pupae P8    28 head, virgin 1-day female    23 head, virgin 4-day female    20 head, virgin 20-day female    18 head, mated 1-day female    20 head, mated 4-day female    15 head, mated 20-day female    19 head, mated 1-day male    16 head, mated 4-day male    21 head, mated 20-day male    28 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    12 digestive system, larvae L3 wandering    19 digestive system, 1-day adult    15 digestive system, 4-day adult    14 digestive system, 20-day adult    14 fat body, larvae L3 wandering    23 fat body, white prepupae    13 fat body, pupae P8    19 carcass, larvae L3 wandering    46 carcass, 1-day adult    15 carcass, 4-day adult    18 carcass, 20-day adult    18 ovary, virgin 4-day female    41 ovary, mated 4-day female    41 testis, mated 4-day male    22 accessory gland, mated 4-day male    22 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages, during early pupal stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    74 embryo 02-04hr    93 embryo 04-06hr    91 embryo 06-08hr    80 embryo 08-10hr    92 embryo 10-12hr    116 embryo 12-14hr    52 embryo 14-16hr    39 embryo 16-18hr    25 embryo 18-20hr    16 embryo 20-22hr    15 embryo 22-24hr    17 larva L1    31 larva L2    50 larva L3 12hr old    39 larva L3 puffstage 1-2    36 larva L3 puffstage 3-6    39 larva L3 puffstage 7-9    45 white prepupae new    48 white prepupae 12hr    32 white prepupae 24hr    59 pupae 2d postWPP    51 pupae 3d postWPP    21 pupae 4d postWPP    16 adult male 01day    22 adult male 05day    24 adult male 30day    27 adult female 01day    38 adult female 05day    55 adult female 30day    58 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (74) embryo 02-04hr  (93) embryo 04-06hr  (91) embryo 06-08hr  (80) embryo 08-10hr  (92) embryo 10-12hr  (116) embryo 12-14hr  (52) embryo 14-16hr  (39) embryo 16-18hr    25 embryo 18-20hr    16 embryo 20-22hr    15 embryo 22-24hr    17 larva L1  (31) larva L2  (50) larva L3 12hr old  (39) larva L3 puffstage 1-2  (36) larva L3 puffstage 3-6  (39) larva L3 puffstage 7-9  (45) white prepupae new  (48) white prepupae 12hr  (32) white prepupae 24hr  (59) pupae 2d postWPP  (51) pupae 3d postWPP    21 pupae 4d postWPP    16 adult male 01day    22 adult male 05day    24 adult male 30day  (27) adult female 01day  (38) adult female 05day  (55) adult female 30day  (58) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    74 embryo 02-04hr    93 embryo 04-06hr    91 embryo 06-08hr    80 embryo 08-10hr    92 embryo 10-12hr  (116) embryo 12-14hr    52 embryo 14-16hr    39 embryo 16-18hr    25 embryo 18-20hr    16 embryo 20-22hr    15 embryo 22-24hr    17 larva L1    31 larva L2    50 larva L3 12hr old    39 larva L3 puffstage 1-2    36 larva L3 puffstage 3-6    39 larva L3 puffstage 7-9    45 white prepupae new    48 white prepupae 12hr    32 white prepupae 24hr    59 pupae 2d postWPP    51 pupae 3d postWPP    21 pupae 4d postWPP    16 adult male 01day    22 adult male 05day    24 adult male 30day    27 adult female 01day    38 adult female 05day    55 adult female 30day    58 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    74 embryo 02-04hr    93 embryo 04-06hr    91 embryo 06-08hr    80 embryo 08-10hr    92 embryo 10-12hr    116 embryo 12-14hr    52 embryo 14-16hr    39 embryo 16-18hr    25 embryo 18-20hr    16 embryo 20-22hr    15 embryo 22-24hr    17 larva L1    31 larva L2    50 larva L3 12hr old    39 larva L3 puffstage 1-2    36 larva L3 puffstage 3-6    39 larva L3 puffstage 7-9    45 white prepupae new    48 white prepupae 12hr    32 white prepupae 24hr    59 pupae 2d postWPP    51 pupae 3d postWPP    21 pupae 4d postWPP    16 adult male 01day    22 adult male 05day    24 adult male 30day    27 adult female 01day    38 adult female 05day    55 adult female 30day    58 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    74 embryo 02-04hr    93 embryo 04-06hr    91 embryo 06-08hr    80 embryo 08-10hr    92 embryo 10-12hr    116 embryo 12-14hr    52 embryo 14-16hr    39 embryo 16-18hr    25 embryo 18-20hr    16 embryo 20-22hr    15 embryo 22-24hr    17 larva L1    31 larva L2    50 larva L3 12hr old    39 larva L3 puffstage 1-2    36 larva L3 puffstage 3-6    39 larva L3 puffstage 7-9    45 white prepupae new    48 white prepupae 12hr    32 white prepupae 24hr    59 pupae 2d postWPP    51 pupae 3d postWPP    21 pupae 4d postWPP    16 adult male 01day    22 adult male 05day    24 adult male 30day    27 adult female 01day    38 adult female 05day    55 adult female 30day    58 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (74) embryo 02-04hr  (93) embryo 04-06hr  (91) embryo 06-08hr  (80) embryo 08-10hr  (92) embryo 10-12hr  (116) embryo 12-14hr  (52) embryo 14-16hr  (39) embryo 16-18hr    25 embryo 18-20hr    16 embryo 20-22hr    15 embryo 22-24hr    17 larva L1  31 larva L2  (50) larva L3 12hr old  (39) larva L3 puffstage 1-2  (36) larva L3 puffstage 3-6  (39) larva L3 puffstage 7-9  (45) white prepupae new  (48) white prepupae 12hr  32 white prepupae 24hr  (59) pupae 2d postWPP  (51) pupae 3d postWPP    21 pupae 4d postWPP    16 adult male 01day    22 adult male 05day    24 adult male 30day  27 adult female 01day  (38) adult female 05day  (55) adult female 30day  (58) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    74 embryo 02-04hr    93 embryo 04-06hr    91 embryo 06-08hr    80 embryo 08-10hr    92 embryo 10-12hr  116 embryo 12-14hr    52 embryo 14-16hr    39 embryo 16-18hr    25 embryo 18-20hr    16 embryo 20-22hr    15 embryo 22-24hr    17 larva L1    31 larva L2    50 larva L3 12hr old    39 larva L3 puffstage 1-2    36 larva L3 puffstage 3-6    39 larva L3 puffstage 7-9    45 white prepupae new    48 white prepupae 12hr    32 white prepupae 24hr    59 pupae 2d postWPP    51 pupae 3d postWPP    21 pupae 4d postWPP    16 adult male 01day    22 adult male 05day    24 adult male 30day    27 adult female 01day    38 adult female 05day    55 adult female 30day    58 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    74 embryo 02-04hr    93 embryo 04-06hr    91 embryo 06-08hr    80 embryo 08-10hr    92 embryo 10-12hr    116 embryo 12-14hr    52 embryo 14-16hr    39 embryo 16-18hr    25 embryo 18-20hr    16 embryo 20-22hr    15 embryo 22-24hr    17 larva L1    31 larva L2    50 larva L3 12hr old    39 larva L3 puffstage 1-2    36 larva L3 puffstage 3-6    39 larva L3 puffstage 7-9    45 white prepupae new    48 white prepupae 12hr    32 white prepupae 24hr    59 pupae 2d postWPP    51 pupae 3d postWPP    21 pupae 4d postWPP    16 adult male 01day    22 adult male 05day    24 adult male 30day    27 adult female 01day    38 adult female 05day    55 adult female 30day    58 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    145 Schneider line 2 Sg4    204 embryonic 1182-4H    70 embryonic GM2    55 embryonic Kc167    56 embryonic S1    86 embryonic S3    127 leg disc CME L1    183 wing disc CME-W2    50 wing disc ML-DmD8    57 wing disc ML-DmD9    85 wing disc ML-DmD16-c3    77 wing disc ML-DmD21    155 wing disc ML-DmD32    72 haltere disc ML-DmD17-c3    38 eye-antennal disc ML-DmD11    55 antennal disc ML-DmD20-c5    108 mixed discs ML-DmD4-c1    101 CNS ML-DmBG1-c1    119 CNS ML-DmBG2-c2    103 tumorous blood cells mbn2    71 ovary fGS/OSS    57 ovary OSC    41 ovary OSS    36 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (145) Schneider line 2 Sg4  (204) embryonic 1182-4H  (70) embryonic GM2  (55) embryonic Kc167  (56) embryonic S1  (86) embryonic S3  (127) leg disc CME L1  (183) wing disc CME-W2  (50) wing disc ML-DmD8  (57) wing disc ML-DmD9  (85) wing disc ML-DmD16-c3  (77) wing disc ML-DmD21  (155) wing disc ML-DmD32  (72) haltere disc ML-DmD17-c3  (38) eye-antennal disc ML-DmD11  (55) antennal disc ML-DmD20-c5  (108) mixed discs ML-DmD4-c1  (101) CNS ML-DmBG1-c1  (119) CNS ML-DmBG2-c2  (103) tumorous blood cells mbn2  (71) ovary fGS/OSS  (57) ovary OSC  (41) ovary OSS  (36) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (145) Schneider line 2 Sg4  (204) embryonic 1182-4H    70 embryonic GM2    55 embryonic Kc167    56 embryonic S1    86 embryonic S3  (127) leg disc CME L1  (183) wing disc CME-W2    50 wing disc ML-DmD8    57 wing disc ML-DmD9    85 wing disc ML-DmD16-c3    77 wing disc ML-DmD21  (155) wing disc ML-DmD32    72 haltere disc ML-DmD17-c3    38 eye-antennal disc ML-DmD11    55 antennal disc ML-DmD20-c5  (108) mixed discs ML-DmD4-c1  101 CNS ML-DmBG1-c1  (119) CNS ML-DmBG2-c2  103 tumorous blood cells mbn2    71 ovary fGS/OSS    57 ovary OSC    41 ovary OSS    36 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    145 Schneider line 2 Sg4    204 embryonic 1182-4H    70 embryonic GM2    55 embryonic Kc167    56 embryonic S1    86 embryonic S3    127 leg disc CME L1    183 wing disc CME-W2    50 wing disc ML-DmD8    57 wing disc ML-DmD9    85 wing disc ML-DmD16-c3    77 wing disc ML-DmD21    155 wing disc ML-DmD32    72 haltere disc ML-DmD17-c3    38 eye-antennal disc ML-DmD11    55 antennal disc ML-DmD20-c5    108 mixed discs ML-DmD4-c1    101 CNS ML-DmBG1-c1    119 CNS ML-DmBG2-c2    103 tumorous blood cells mbn2    71 ovary fGS/OSS    57 ovary OSC    41 ovary OSS    36 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    145 Schneider line 2 Sg4    204 embryonic 1182-4H    70 embryonic GM2    55 embryonic Kc167    56 embryonic S1    86 embryonic S3    127 leg disc CME L1    183 wing disc CME-W2    50 wing disc ML-DmD8    57 wing disc ML-DmD9    85 wing disc ML-DmD16-c3    77 wing disc ML-DmD21    155 wing disc ML-DmD32    72 haltere disc ML-DmD17-c3    38 eye-antennal disc ML-DmD11    55 antennal disc ML-DmD20-c5    108 mixed discs ML-DmD4-c1    101 CNS ML-DmBG1-c1    119 CNS ML-DmBG2-c2    103 tumorous blood cells mbn2    71 ovary fGS/OSS    57 ovary OSC    41 ovary OSS    36 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (145) Schneider line 2 Sg4  (204) embryonic 1182-4H  (70) embryonic GM2  (55) embryonic Kc167  (56) embryonic S1  (86) embryonic S3  (127) leg disc CME L1  (183) wing disc CME-W2  (50) wing disc ML-DmD8  (57) wing disc ML-DmD9  (85) wing disc ML-DmD16-c3  (77) wing disc ML-DmD21  (155) wing disc ML-DmD32  (72) haltere disc ML-DmD17-c3  (38) eye-antennal disc ML-DmD11  (55) antennal disc ML-DmD20-c5  (108) mixed discs ML-DmD4-c1  (101) CNS ML-DmBG1-c1  (119) CNS ML-DmBG2-c2  (103) tumorous blood cells mbn2  (71) ovary fGS/OSS  (57) ovary OSC  (41) ovary OSS  (36) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (145) Schneider line 2 Sg4  (204) embryonic 1182-4H    70 embryonic GM2    55 embryonic Kc167    56 embryonic S1    86 embryonic S3  127 leg disc CME L1  (183) wing disc CME-W2    50 wing disc ML-DmD8    57 wing disc ML-DmD9    85 wing disc ML-DmD16-c3    77 wing disc ML-DmD21  (155) wing disc ML-DmD32    72 haltere disc ML-DmD17-c3    38 eye-antennal disc ML-DmD11    55 antennal disc ML-DmD20-c5  108 mixed discs ML-DmD4-c1  101 CNS ML-DmBG1-c1  119 CNS ML-DmBG2-c2  103 tumorous blood cells mbn2    71 ovary fGS/OSS    57 ovary OSC    41 ovary OSS    36 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    145 Schneider line 2 Sg4    204 embryonic 1182-4H    70 embryonic GM2    55 embryonic Kc167    56 embryonic S1    86 embryonic S3    127 leg disc CME L1    183 wing disc CME-W2    50 wing disc ML-DmD8    57 wing disc ML-DmD9    85 wing disc ML-DmD16-c3    77 wing disc ML-DmD21    155 wing disc ML-DmD32    72 haltere disc ML-DmD17-c3    38 eye-antennal disc ML-DmD11    55 antennal disc ML-DmD20-c5    108 mixed discs ML-DmD4-c1    101 CNS ML-DmBG1-c1    119 CNS ML-DmBG2-c2    103 tumorous blood cells mbn2    71 ovary fGS/OSS    57 ovary OSC    41 ovary OSS    36 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    23 cold shock, 4-day adult    17 heat shock, 4-day adult    38 Cadmium 50 mM 6 hrs, larvae L3    54 Cadmium 50 mM 12 hrs, larvae L3    42 Cadmium 50 mM 48 hrs, 4-day adult    27 Cadmium 100 mM 48 hrs, 4-day adult    32 Copper 0.5 mM 12 hrs, larvae L3    36 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    22 Zinc 4.5 mM 48 hrs, 4-day adult    17 Ethanol 2.5% 3 hrs, larvae L3    37 Ethanol 5% 3 hrs, larvae L3    31 Ethanol 10% 3 hrs, larvae L3    39 Caffeine 1.5 mg/ml 4 hrs, larvae L3    19 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    30 Caffeine 25 mg/ml 48 hrs, 4-day adult    24 Paraquat 5 mM 48 hrs, 4-day adult    41 Paraquat 10 mM 48 hrs, 4-day adult    34 Rotenone 2 μg 12 hrs, larvae L3    31 Rotenone 8 μg 12 hrs, larvae L3    41 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    23 cold shock, 4-day adult    17 heat shock, 4-day adult  (38) Cadmium 50 mM 6 hrs, larvae L3  (54) Cadmium 50 mM 12 hrs, larvae L3  (42) Cadmium 50 mM 48 hrs, 4-day adult  (27) Cadmium 100 mM 48 hrs, 4-day adult  (32) Copper 0.5 mM 12 hrs, larvae L3  (36) Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    22 Zinc 4.5 mM 48 hrs, 4-day adult    17 Ethanol 2.5% 3 hrs, larvae L3  (37) Ethanol 5% 3 hrs, larvae L3  (31) Ethanol 10% 3 hrs, larvae L3  (39) Caffeine 1.5 mg/ml 4 hrs, larvae L3    19 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (30) Caffeine 25 mg/ml 48 hrs, 4-day adult    24 Paraquat 5 mM 48 hrs, 4-day adult  (41) Paraquat 10 mM 48 hrs, 4-day adult  (34) Rotenone 2 μg 12 hrs, larvae L3  (31) Rotenone 8 μg 12 hrs, larvae L3  (41) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    23 cold shock, 4-day adult    17 heat shock, 4-day adult    38 Cadmium 50 mM 6 hrs, larvae L3    54 Cadmium 50 mM 12 hrs, larvae L3    42 Cadmium 50 mM 48 hrs, 4-day adult    27 Cadmium 100 mM 48 hrs, 4-day adult    32 Copper 0.5 mM 12 hrs, larvae L3    36 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    22 Zinc 4.5 mM 48 hrs, 4-day adult    17 Ethanol 2.5% 3 hrs, larvae L3    37 Ethanol 5% 3 hrs, larvae L3    31 Ethanol 10% 3 hrs, larvae L3    39 Caffeine 1.5 mg/ml 4 hrs, larvae L3    19 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    30 Caffeine 25 mg/ml 48 hrs, 4-day adult    24 Paraquat 5 mM 48 hrs, 4-day adult    41 Paraquat 10 mM 48 hrs, 4-day adult    34 Rotenone 2 μg 12 hrs, larvae L3    31 Rotenone 8 μg 12 hrs, larvae L3    41 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    23 cold shock, 4-day adult    17 heat shock, 4-day adult    38 Cadmium 50 mM 6 hrs, larvae L3    54 Cadmium 50 mM 12 hrs, larvae L3    42 Cadmium 50 mM 48 hrs, 4-day adult    27 Cadmium 100 mM 48 hrs, 4-day adult    32 Copper 0.5 mM 12 hrs, larvae L3    36 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    22 Zinc 4.5 mM 48 hrs, 4-day adult    17 Ethanol 2.5% 3 hrs, larvae L3    37 Ethanol 5% 3 hrs, larvae L3    31 Ethanol 10% 3 hrs, larvae L3    39 Caffeine 1.5 mg/ml 4 hrs, larvae L3    19 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    30 Caffeine 25 mg/ml 48 hrs, 4-day adult    24 Paraquat 5 mM 48 hrs, 4-day adult    41 Paraquat 10 mM 48 hrs, 4-day adult    34 Rotenone 2 μg 12 hrs, larvae L3    31 Rotenone 8 μg 12 hrs, larvae L3    41 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    23 cold shock, 4-day adult    17 heat shock, 4-day adult    38 Cadmium 50 mM 6 hrs, larvae L3    54 Cadmium 50 mM 12 hrs, larvae L3    42 Cadmium 50 mM 48 hrs, 4-day adult    27 Cadmium 100 mM 48 hrs, 4-day adult    32 Copper 0.5 mM 12 hrs, larvae L3    36 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    22 Zinc 4.5 mM 48 hrs, 4-day adult    17 Ethanol 2.5% 3 hrs, larvae L3    37 Ethanol 5% 3 hrs, larvae L3    31 Ethanol 10% 3 hrs, larvae L3    39 Caffeine 1.5 mg/ml 4 hrs, larvae L3    19 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    30 Caffeine 25 mg/ml 48 hrs, 4-day adult    24 Paraquat 5 mM 48 hrs, 4-day adult    41 Paraquat 10 mM 48 hrs, 4-day adult    34 Rotenone 2 μg 12 hrs, larvae L3    31 Rotenone 8 μg 12 hrs, larvae L3    41 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    23 cold shock, 4-day adult    17 heat shock, 4-day adult  (38) Cadmium 50 mM 6 hrs, larvae L3  (54) Cadmium 50 mM 12 hrs, larvae L3  (42) Cadmium 50 mM 48 hrs, 4-day adult  27 Cadmium 100 mM 48 hrs, 4-day adult  32 Copper 0.5 mM 12 hrs, larvae L3  (36) Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    22 Zinc 4.5 mM 48 hrs, 4-day adult    17 Ethanol 2.5% 3 hrs, larvae L3  (37) Ethanol 5% 3 hrs, larvae L3  31 Ethanol 10% 3 hrs, larvae L3  (39) Caffeine 1.5 mg/ml 4 hrs, larvae L3    19 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  30 Caffeine 25 mg/ml 48 hrs, 4-day adult    24 Paraquat 5 mM 48 hrs, 4-day adult  (41) Paraquat 10 mM 48 hrs, 4-day adult  (34) Rotenone 2 μg 12 hrs, larvae L3  31 Rotenone 8 μg 12 hrs, larvae L3  (41) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    23 cold shock, 4-day adult    17 heat shock, 4-day adult    38 Cadmium 50 mM 6 hrs, larvae L3    54 Cadmium 50 mM 12 hrs, larvae L3    42 Cadmium 50 mM 48 hrs, 4-day adult    27 Cadmium 100 mM 48 hrs, 4-day adult    32 Copper 0.5 mM 12 hrs, larvae L3    36 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    22 Zinc 4.5 mM 48 hrs, 4-day adult    17 Ethanol 2.5% 3 hrs, larvae L3    37 Ethanol 5% 3 hrs, larvae L3    31 Ethanol 10% 3 hrs, larvae L3    39 Caffeine 1.5 mg/ml 4 hrs, larvae L3    19 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    30 Caffeine 25 mg/ml 48 hrs, 4-day adult    24 Paraquat 5 mM 48 hrs, 4-day adult    41 Paraquat 10 mM 48 hrs, 4-day adult    34 Rotenone 2 μg 12 hrs, larvae L3    31 Rotenone 8 μg 12 hrs, larvae L3    41 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    23 cold shock, 4-day adult    17 heat shock, 4-day adult    38 Cadmium 50 mM 6 hrs, larvae L3    54 Cadmium 50 mM 12 hrs, larvae L3    42 Cadmium 50 mM 48 hrs, 4-day adult    27 Cadmium 100 mM 48 hrs, 4-day adult    32 Copper 0.5 mM 12 hrs, larvae L3    36 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    22 Zinc 4.5 mM 48 hrs, 4-day adult    17 Ethanol 2.5% 3 hrs, larvae L3    37 Ethanol 5% 3 hrs, larvae L3    31 Ethanol 10% 3 hrs, larvae L3    39 Caffeine 1.5 mg/ml 4 hrs, larvae L3    19 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    30 Caffeine 25 mg/ml 48 hrs, 4-day adult    24 Paraquat 5 mM 48 hrs, 4-day adult    41 Paraquat 10 mM 48 hrs, 4-day adult    34 Rotenone 2 μg 12 hrs, larvae L3    31 Rotenone 8 μg 12 hrs, larvae L3    41 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_03 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	BDGP expression data • FI06486 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004132 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG30498-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal boca1 lethal | pupal stage | recessive boca1 viable, with Scer\GAL4pnr-MD237 bocaGD5483 Phenotype manifest in Allele adult head | dorsal | somatic clone boca1 dorsocentral bristle | somatic clone boca1 eye | ectopic | somatic clone boca1 proboscis bocadsRNA.C ventral thoracic disc | distal boca1 wing disc boca1 wing margin bristle | cell autonomous | somatic clone boca1 wing margin bristle | cell non-autonomous | ectopic | somatic clone boca1 yolk | germline clone boca1
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of boca Class Mutagen Stocks Known lesion boca1 ethyl methanesulfonate 2 Yes
Alleles Carried on Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Allele of boca Class Mutagen Stocks Known lesion bocaGD5483 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes bocaJF02863 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes bocaKK109195 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes bocadsRNA.C in vitro construct - RNAi 0 Yes bocadsRNA.Scer\UAS in vitro construct - RNAi 0 Yes bocaMtnA.T:SV5\V5,T:Zzzz\His6 in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct 0 Yes bocaNIG.1364R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes bocaScer\UAS.cCa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)cn-S5 (Heitzler et al., 1993) Df(2R)cn-S6 (Heitzler et al., 1993) Df(2R)Drlrv5 (Heitzler et al., 1993) Df(2R)Drlrv7 (Heitzler et al., 1993) Df(2R)Drlrv15 (Culi and Mann, 2003, Heitzler et al., 1993) Df(2R)Drlrv18 (Heitzler et al., 1993) Df(2R)Drlrv20 (Heitzler et al., 1993) Df(2R)Drlrv21 (Heitzler et al., 1993) Df(2R)Drlrv24 (Heitzler et al., 1993) Df(2R)Drlrv26 (Heitzler et al., 1993) Df(2R)Drlrv30 (Heitzler et al., 1993) Df(2R)Exel6052 (Ryder, 2004.4.26) Df(2R)Exel6053 (Ryder, 2004.4.26) Df(2R)NCX9 (Heitzler et al., 1993) Df(2R)NCX11 (Heitzler et al., 1993) Df(2R)NCX13 (Eeken et al., 2001) Df(2R)sple-D3 (Heitzler et al., 1993, Roote, 1996.8) Df(2R)sple-N3 (Heitzler et al., 1993) Df(2R)ST1 (Eeken et al., 2001)
Not disrupted in	Df(2R)cn-S8 (Heitzler et al., 1993, Roote, 1996.8) Df(2R)cos-2 (Heitzler et al., 1993) Df(2R)cos-3 (Heitzler et al., 1993) Df(2R)Drlrv3 (Heitzler et al., 1993) Df(2R)Drlrv17 (Heitzler et al., 1993) Df(2R)Drlrv22 (Heitzler et al., 1993) Df(2R)Drlrv25 (Heitzler et al., 1993) Df(2R)Drlrv28 (Heitzler et al., 1993) Df(2R)DX1 (Heitzler et al., 1993) Df(2R)DX14 (Heitzler et al., 1993) Df(2R)EW60 (Heitzler et al., 1993) Df(2R)H23 (Heitzler et al., 1993) Df(2R)nap2 (Heitzler et al., 1993) Df(2R)NCX5 (Heitzler et al., 1993) Df(2R)NCX8 (Eeken et al., 2001, Heitzler et al., 1993) Df(2R)NCX10 (Heitzler et al., 1993) Df(2R)pk-N5 (Heitzler et al., 1993) Df(2R)pwn5 (Heitzler et al., 1993) Df(2R)sple-D1 (Heitzler et al., 1993) Df(2R)sple-D2 (Heitzler et al., 1993) Df(2R)sple-J1 (Heitzler et al., 1993) Df(2R)sple-J2 (Heitzler et al., 1993)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD5483} NA P{KK109195} NA P{NIG.1364R} NA P{TRiP.JF02863} NA P{UAS-boca.C} NA P{UAS-boca-RNAi} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{PTT-GB}CB02070 NA
Gene Ontology: Function, Process & Cellular Component ( 9 unique terms )
Terms Based on Experimental Evidence ( 9 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
ER to Golgi vesicle-mediated transport inferred from expression pattern (Culi and Mann, 2003) low-density lipoprotein receptor particle metabolic process inferred from mutant phenotype (Culi and Mann, 2003) oogenesis inferred from mutant phenotype (Culi and Mann, 2003) proboscis development inferred from mutant phenotype (Culi and Mann, 2002, Culi and Mann, 2003) protein targeting to membrane inferred from mutant phenotype (Culi and Mann, 2003) Wnt receptor signaling pathway inferred from genetic interaction with wg (Culi and Mann, 2003) inferred from mutant phenotype (Culi and Mann, 2003)
Cellular Component
CV term Evidence References
apical part of cell inferred from direct assay (Culi and Mann, 2003) cytoplasm inferred from direct assay (Culi and Mann, 2003) endoplasmic reticulum lumen inferred from direct assay (Culi and Mann, 2003)
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
boca - Adam experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) boca - Art4 experimental knowledge based (Guruharsha et al., 2011) boca - BI-1 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) boca - Bap60 experimental knowledge based (Guruharsha et al., 2011) boca - CG11505 experimental knowledge based (Guruharsha et al., 2011) boca - CG11876 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) boca - CG12493 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) boca - CG13539 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) boca - CG13630 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) boca - CG14024 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) boca - CG14480 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) boca - CG14482 experimental knowledge based (Guruharsha et al., 2011) boca - CG15625 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) boca - CG16817 experimental knowledge based (Guruharsha et al., 2011) boca - CG17002 experimental knowledge based (Guruharsha et al., 2011) boca - CG17259 experimental knowledge based (Guruharsha et al., 2011) boca - CG1889 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) boca - CG2017 experimental knowledge based (Guruharsha et al., 2011) boca - CG2064 experimental knowledge based (Guruharsha et al., 2011) boca - CG2183 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) boca - CG3008 experimental knowledge based (Guruharsha et al., 2011) boca - CG3045 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) boca - CG30491 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) boca - CG32479 experimental knowledge based (Guruharsha et al., 2011) boca - CG34159 experimental knowledge based (Guruharsha et al., 2011) boca - CG3570 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) boca - CG3689 experimental knowledge based (Guruharsha et al., 2011) boca - CG4169 experimental knowledge based (Guruharsha et al., 2011) boca - CG5623 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) boca - CG5792 experimental knowledge based (Guruharsha et al., 2011) boca - CG7185 experimental knowledge based (Guruharsha et al., 2011) boca - CG7542 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) boca - CG8258 experimental knowledge based (Guruharsha et al., 2011) boca - CG9467 experimental knowledge based (Guruharsha et al., 2011) boca - CSN4 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) boca - Cctγ experimental knowledge based (Guruharsha et al., 2011) boca - Cdk8 experimental knowledge based (Guruharsha et al., 2011) boca - Chc experimental knowledge based (Guruharsha et al., 2011) boca - Cnx99A experimental knowledge based (Guruharsha et al., 2011) boca - Cpr67B experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) boca - Cyp9b2 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) boca - Der-2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) boca - Ent2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) boca - Fim experimental knowledge based (Guruharsha et al., 2011) boca - Fmo-2 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) boca - Glt experimental knowledge based (Guruharsha et al., 2011) boca - Gp210 experimental knowledge based (Guruharsha et al., 2011) boca - Gyk experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) boca - MED10 experimental knowledge based (Guruharsha et al., 2011) boca - MED11 experimental knowledge based (Guruharsha et al., 2011) boca - MED14 experimental knowledge based (Guruharsha et al., 2011) boca - MED15 experimental knowledge based (Guruharsha et al., 2011) boca - MED16 experimental knowledge based (Guruharsha et al., 2011) boca - MED17 experimental knowledge based (Guruharsha et al., 2011) boca - MED18 experimental knowledge based (Guruharsha et al., 2011) boca - MED20 experimental knowledge based (Guruharsha et al., 2011) boca - MED23 experimental knowledge based (Guruharsha et al., 2011) boca - MED27 experimental knowledge based (Guruharsha et al., 2011) boca - MED30 experimental knowledge based (Guruharsha et al., 2011) boca - MED4 experimental knowledge based (Guruharsha et al., 2011) boca - MED6 experimental knowledge based (Guruharsha et al., 2011) boca - MED7 experimental knowledge based (Guruharsha et al., 2011) boca - MED8 experimental knowledge based (Guruharsha et al., 2011) boca - Mpcp experimental knowledge based (Guruharsha et al., 2011) boca - Nacα experimental knowledge based (Guruharsha et al., 2011) boca - Nup358 experimental knowledge based (Guruharsha et al., 2011) boca - Odc1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) boca - Pa1 experimental knowledge based (Guruharsha et al., 2011) boca - Pi3K68D experimental knowledge based (Guruharsha et al., 2011) boca - Psi experimental knowledge based (Guruharsha et al., 2011) boca - RpLP0 experimental knowledge based (Guruharsha et al., 2011) boca - RpS10b experimental knowledge based (Guruharsha et al., 2011) boca - RpS19a experimental knowledge based (Guruharsha et al., 2011) boca - Rrp45 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) boca - Ser7 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) boca - Sucb experimental knowledge based (Guruharsha et al., 2011) boca - TER94 experimental knowledge based (Guruharsha et al., 2011) boca - alrm anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) boca - bl experimental knowledge based (Guruharsha et al., 2011) boca - bor experimental knowledge based (Guruharsha et al., 2011) boca - dsh experimental knowledge based (Guruharsha et al., 2011) boca - ebi experimental knowledge based (Guruharsha et al., 2011) boca - fan anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) boca - fh anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) boca - ix experimental knowledge based (Guruharsha et al., 2011) boca - l(1)G0156 experimental knowledge based (Guruharsha et al., 2011) boca - mor experimental knowledge based (Guruharsha et al., 2011) boca - ptip experimental knowledge based (Guruharsha et al., 2011) boca - r experimental knowledge based (Guruharsha et al., 2011) boca - scf experimental knowledge based (Guruharsha et al., 2011) boca - shrb anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) boca - vkg experimental knowledge based (Guruharsha et al., 2011) boca - α-Spec experimental knowledge based (Guruharsha et al., 2011)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions boca allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0004132 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 48986
Orthologs
OrthoDB Orthologs (39) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6XKVTJ Dipteran inclusive ortholog search EOG65MNFQ Insect inclusive ortholog search EOG6547W8 Arthropod inclusive ortholog search EOG63TXC5 Metazoa inclusive ortholog search EOG651SKZ
Orthologs in Drosophila Species (EOG6XKVTJ)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\boca     Drosophila simulans   Dsim\GD10238 Y   Drosophila sechellia   Dsec\GM20777 Y   Drosophila erecta   Dere\GG10730 Y   Drosophila yakuba   Dyak\GE23816 Y   Drosophila ananassae   Dana\GF11710 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA15885 Y   Drosophila persimilis   Dper\GL20104 Y   Drosophila willistoni   Dwil\GK10712 Y   Drosophila virilis   Dvir\GJ20269 Y   Drosophila mojavensis   Dmoj\GI19202 Y   Drosophila grimshawi   Dgri\GH20023 Y
Orthologs in non-Drosophila Dipterans (EOG65MNFQ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL010504   Aedes aegypti Yellow fever mosquito  Aaeg\AAEL013307   Anopheles gambiae Malaria mosquito  Agam\AGAP005081   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ010816
Orthologs in non-Dipteran Insects (EOG6547W8)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB41183   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG011476   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH18363   Atta cephalotes Leafcutter ant  Acep\ACEP14103   Camponotus floridanus Florida carpenter ant  Cflo\CFLO19921   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL13306   Linepithema humile Argentine ant  Lhum\LH22650   Pogonomyrmex barbatus Red harvester ant  Pbar\PB17682   Solenopsis invicta Red fire ant  Sinv\SINV20171   Acyrthosiphon pisum Pea aphid  Apim\ACYPI007396   Bombyx mori Silkmoth  Bmor\BGIBMGA005372   Pediculus humanus Human body louse  Phum\PHUM390880   Tribolium castaneum Red flour beetle  Tcas\TC000405
Orthologs in non-Insect Arthropods (EOG63TXC5)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\COX3   Ixodes scapularis Deer tick  Isca\ISCW007279
Orthologs in non-Arthropod Metazoa (EOG651SKZ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\bmy-1   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_015424gn   Danio rerio Zebrafish  Drer\mesdc2   Xenopus tropicalis Western clawed frog  Xtro\mesdc2   Gallus gallus Domestic chicken  Ggal\MESDC2   Mus musculus House mouse  Mmus\Mesdc2   Rattus norvegicus Norway rat  Rnor\Mesdc2   Homo sapiens Human  Hsap\MESDC2
Human Orthologs (1)
Gene OMIM HGNC Hsap\MESDC2
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD10238 Drosophila sechellia Dsec\GM20777 Drosophila erecta Dere\GG10730 Drosophila yakuba Dyak\GE23816 Drosophila ananassae Dana\GF11710 Drosophila pseudoobscura pseudoobscura Dpse\GA15885 Drosophila persimilis Dper\GL20104 Drosophila willistoni Dwil\GK10712 Drosophila virilis Dvir\GJ20269 Drosophila mojavensis Dmoj\GI19202 Drosophila grimshawi Dgri\GH20023
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	28029 y1 v1; P{TRiP.JF02863}attP2 4129 Dp(?;2)bwD, boca1 bwD/CyO
Kyoto	107596 Dp(?;2)bwD, boca1 bwD/CyO
VDRC	v108406 P{KK109195}VIE-260B v13457 w1118; P{GD5483}v13457
Genomic Clones ( 2 )
	BACR04G20 BACR04H12 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 6 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	SD08653
Other clones	FI06486
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GM16274
Other clones	Dmel_neb_015208_0177_1361 Dmel_neb_015766_0361_2110 IP07815
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0004132 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 48986
Antibody Information
Other Information
Discoverer
Etymology
	'boca' means mouth in Catalan. (Culi and Mann, 2002)
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: CG30498 l(2)43Ea (Culi, 2002.3.22)
Additional comments	Annotation CG1364 split into CG30499 and CG30498 (boca) in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003)
Other Comments
	boca is an essential component of the wg pathway but is more generally required for the activities of multiple LDL receptor family members. (Culi and Mann, 2003) boca is essential for proboscis development, and viability. (Culi and Mann, 2002) dsRNA causes embryos to develop into adults with reduced or absent proboscis but other fly body parts are apparently normal. (Culi and Mann, 2002)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_165541 RefSeq (Proteins) • NP_724578 DDBJ / EMBL / GenBank • AAF59229 AAL39985 AI542360 AW944564 AY069840 Entrez Gene - A searchable database of RefSeq genes. • 48986 UniProtKB/Swiss-Prot • Q8T9B6
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Mesoderm development candidate 2 (IPR019330) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • FI06486
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0004132 DRSC - Results from RNAi screens. • FBgn0004132 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004132 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG30498-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0004132 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 48986 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 48986 modMine - Data generated by the modENCODE project. • FBgn0004132
Synonyms & Secondary IDs ( 7 )
Reported As
Symbol Synonym	boca (Buszczak et al., 2007, Culi and Mann, 2003, Khaliullina et al., 2009, Japanese National Institute of Genetics, 2012.5.21) Boca (Clevers, 2006, Lee and Cooley, 2007, Tan et al., 2009, Tien et al., 2008, Kelkar and Dobberstein, 2009, Wakefield and Tear, 2006, Tong et al., 2011, Chen et al., 2010, Okajima et al., 2008, Tsuda et al., 2008) CG1364 (Culi, 2002.3.22, Holdener, 2000.7.28, BDGP Project Members, 2000-, ) CG30498 (Keleman et al., 2009.8.5, Perkins et al., 2009, Kondylis et al., 2011, Cammarato et al., 2011, Pflieger et al., 2008, Qin et al., 2008) dmBoca (Collins and Hendrickson, 2011) l(2)43Ea (Eeken et al., 2001, Heitzler et al., 1993, )
Name Synonym	boca (Culi and Mann, 2002, Schlesinger and Shilo, 2005, Cammarato et al., 2011) Boca (Kondylis et al., 2011, Texada et al., 2011) lethal(2)43Ea
Secondary FlyBase IDs
	FBgn0033193 FBgn0050498
References ( 47 )
Generate a list of	All references relating to this gene ( 47 )
List References by type	Research paper  ( 21 ) Supplementary material  ( 6 ) Review  ( 4 ) Personal communication to FlyBase  ( 10 ) Abstract  ( 1 ) FlyBase analysis  ( 2 ) Stock list  ( 1 ) Website  ( 1 )
Recent research papers ( 4 )
	Collins and Hendrickson, 2011, Structure 19(3): 324--336 Structural characterization of the Boca/Mesd maturation factors for LDL-receptor-type β propeller domains. [FBrf0214357] Kondylis et al., 2011, PLoS ONE 6(2): e17173 Identification of ER Proteins Involved in the Functional Organisation of the Early Secretory Pathway in Drosophila Cells by a Targeted RNAi Screen. [FBrf0213167] Texada et al., 2011, Exp. Cell Res. 317(4): 474--487 Tropomyosin is an interaction partner of the Drosophila coiled coil protein Yuri Gagarin. [FBrf0212786] Tong et al., 2011, Neuron 71(3): 447--459 Rich Regulates Target Specificity of Photoreceptor Cells and N-Cadherin Trafficking in the Drosophila Visual System via Rab6. [FBrf0214681] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...