FlyBase Gene Report: Dmel\boca

General Information

Symbol

Dmel\boca

Species

D. melanogaster

Name

boca

Annotation Symbol

CG30498

Feature Type

protein_coding_gene

FlyBase ID

FBgn0004132

Gene Model Status

Current

Stock Availability

7 publicly available

Gene Snapshot

boca (boca) encodes an endoplasmic reticulum protein that is evolutionarily conserved. It is required for the intracellular trafficking of members of the low-density lipoprotein family of receptors, including the one encoded by arr. As such, boca mutants are compromised for a number of pathways including Wingless signaling. [Date last reviewed: 2019-03-21]

Other Summaries

Alliance
Auto summary
UniProtKB
Interactive Fly

Also Known As

l(2)43Ea

Key Links

Genomic Location

Cytogenetic map

43D7-43D7

Sequence location

2R:7,565,873..7,566,738 [-]

Recombination map

2-56

Sequence

Get Decorated FASTA

Genomic Maps

GBrowse JBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

[Detailed GO annotations]

Protein Family (UniProt)

Belongs to the MESD family. (Q8T9B6)

Protein Signatures (InterPro)

LRP chaperone MESD

Molecular Function (GO)
[Detailed GO annotations]

Experimental Evidence

Predictions / Assertions

Summaries

Protein Function (UniProtKB)

Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wg pathway, since some LDLRs are coreceptors for the canonical Wnt pathway.

(UniProt, Q8T9B6)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the GBrowse view of Dmel\boca or the JBrowse view of Dmel\boca for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.42

Gene model reviewed during 5.48

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

boca-RA

FBtr0088953

NM_165541

704

180

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

boca-PA

FBpp0088027

21.0

180

4.53

NP_724578

AAF59229

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Subunit Structure (UniProtKB)

Monomer (By similarity). Interacts with Arrow and Yolkless.

(UniProt, Q8T9B6)

Domain

The LDLR maturation activity resides in the N- and C-terminal unstructured regions.

(UniProt, Q8T9B6)

Crossreferences

InterPro - A database of protein families, domains and functional sites

LRP chaperone MESD

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q8T9B6

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\boca using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

boca_1

Linkouts

Gene Ontology (8 terms)

Molecular Function (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (3 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

endoplasmic reticulum to Golgi vesicle-mediated transport

inferred from expression pattern

(Culi and Mann, 2003)

protein folding

inferred from mutant phenotype

(Culi and Mann, 2003)

protein targeting to membrane

inferred from mutant phenotype

(Culi and Mann, 2003)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (5 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

apical part of cell

inferred from direct assay

(Culi and Mann, 2003)

cytoplasm

inferred from direct assay

(Culi and Mann, 2003)

endomembrane system

inferred from high throughput direct assay

(Tan et al., 2009)

endoplasmic reticulum

inferred from direct assay

(Abrams et al., 2013)

endoplasmic reticulum lumen

inferred from direct assay

(Culi and Mann, 2003)

Terms Based on Predictions or Assertions (0 terms)

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism | ubiquitous

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 13 -- 16

organism | ubiquitous

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 15

embryonic/larval salivary gland body

• endoplasmic reticulum

(Abrams et al., 2013)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

day 7 of adulthood -- day 49 of adulthood

adult heart

(Cammarato et al., 2011)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

apical part of cell

inferred from direct assay

(Culi and Mann, 2003)

cytoplasm

inferred from direct assay

(Culi and Mann, 2003)

endomembrane system

inferred from high throughput direct assay

(Tan et al., 2009)

endoplasmic reticulum

inferred from direct assay

(Abrams et al., 2013)

endoplasmic reticulum lumen

inferred from direct assay

(Culi and Mann, 2003)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\boca in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\boca

View exonic expression by tissue for Dmel\boca

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0004132

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0004132

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG30498-RA

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG30498

Flygut - An atlas of the Drosophila adult midgut

FBgn0004132

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 3 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 6 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of boca

Transgenic constructs containing regulatory region of boca

Deletions and Duplications ( 42 )

Not disrupted in

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal

boca¹

lethal (with Df(2R)k08815)

boca¹

lethal - all die before end of pupal stage | recessive

boca¹

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

boca^GD5483

viable, with Scer\GAL4^Mef2.PR

boca^GD5483

viable, with Scer\GAL4^pnr-MD237

boca^GD5483

viable, with Scer\GAL4^tin.CΔ4

boca^GD5483

Other Phenotypes

Allele

some die during pupal stage | recessive

boca¹

Phenotype manifest in

Allele

adult head | dorsal | somatic clone

boca¹

dorsocentral bristle | somatic clone

boca¹

eye | ectopic | somatic clone

boca¹

ventral thoracic disc | distal

boca¹

wing disc

boca¹

wing margin bristle | cell autonomous | somatic clone

boca¹

wing margin bristle | cell non-autonomous | ectopic | somatic clone

boca¹

yolk | germline clone

boca¹

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v7.1)

Homo sapiens (Human) (1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\MESD

13 of 15

Yes

Model Organism Orthologs (via DIOPT v7.1)

Mus musculus (laboratory mouse) (1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Mesd

13 of 15

Yes

Rattus norvegicus (Norway rat) (1)

Rnor\Mesd

12 of 13

Yes

Xenopus tropicalis (Western clawed frog) (2)

Xtro\mesd

11 of 12

Yes

Xtro\LOC105946188

1 of 12

Yes

Danio rerio (Zebrafish) (1)

Drer\mesd

11 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (3)

Cele\bmy-1

14 of 15

Yes

Cele\srg-69

2 of 15

Yes

Cele\F10D7.10

1 of 15

Yes

Arabidopsis thaliana (thale-cress) (1)

Atha\AT2G46000

1 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG09190HM1 )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila melanogaster

fruit fly

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA15885

Drosophila persimilis

Dper\GL20104

Drosophila willistoni

Dwil\GK10712

Drosophila virilis

Dvir\GJ20269

Drosophila mojavensis

Dmoj\GI19202

Drosophila grimshawi

Dgri\GH20023

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150EO6 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17024199

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_12223

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL010504

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL013307

Anopheles gambiae

Malaria mosquito

Agam\AGAP005081

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ010816

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0HW1 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA005372

Danaus plexippus

Monarch butterfly

Dple\DPOGS211251-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL012694

Apis florea

Little honeybee

Aflo\2147729459

Apis mellifera

Western honey bee

Amel\GB41183

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP23630

Bombus terrestris

Buff-tailed bumblebee

Bter\15205865

Linepithema humile

Argentine ant

Lhum\LH22650

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:0013ff

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG011476

Tribolium castaneum

Red flour beetle

Tcas\TC000405

Pediculus humanus

Human body louse

Phum\PHUM390880

Rhodnius prolixus

Kissing bug

Rpro\RPRC000039

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI007396

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_00760

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0HZ1 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR007108

Ixodes scapularis

Black-legged tick

Isca\ISCW007279

Stegodyphus mimosarum

African social velvet spider

Smim\KFM78612.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM81405.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur12g01420

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_307758

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0TTK )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Mdc2

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000003103

Gallus gallus

Domestic chicken

Ggal\MESDC2

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v7.1)

Drosophila melanogaster (Fruit fly) (0)

No records found.

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

MESD; mesoderm development LRP chaperone

13 of 15

607783

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

boca - Art4

experimental knowledge based

(Guruharsha et al., 2011)

boca - BI-1

experimental knowledge based

(Guruharsha et al., 2011)

boca - Bap60

experimental knowledge based

(Guruharsha et al., 2011)

boca - CCT3

experimental knowledge based

(Guruharsha et al., 2011)

boca - CCT8

experimental knowledge based

(Guruharsha et al., 2011)

boca - CG13630

experimental knowledge based

(Guruharsha et al., 2011)

boca - CG17002

experimental knowledge based

(Guruharsha et al., 2011)

boca - CG1889

experimental knowledge based

(Guruharsha et al., 2011)

boca - CG2017

experimental knowledge based

(Guruharsha et al., 2011)

boca - CG2064

experimental knowledge based

(Guruharsha et al., 2011)

boca - CG3008

experimental knowledge based

(Guruharsha et al., 2011)

boca - CG3045

experimental knowledge based

(Guruharsha et al., 2011)

boca - CG34159

experimental knowledge based

(Guruharsha et al., 2011)

boca - CG9467

experimental knowledge based

(Guruharsha et al., 2011)

boca - CSN4

experimental knowledge based

(Guruharsha et al., 2011)

boca - Cdk8

experimental knowledge based

(Guruharsha et al., 2011)

boca - Chc

experimental knowledge based

(Guruharsha et al., 2011)

boca - Cnx99A

experimental knowledge based

(Guruharsha et al., 2011)

boca - Cpr67B

experimental knowledge based

(Guruharsha et al., 2011)

boca - Cpsf5

experimental knowledge based

(Guruharsha et al., 2011)

boca - Cpsf6

experimental knowledge based

(Guruharsha et al., 2011)

boca - Cyp9b2

experimental knowledge based

(Guruharsha et al., 2011)

boca - Fim

experimental knowledge based

(Guruharsha et al., 2011)

boca - Fmo-2

experimental knowledge based

(Guruharsha et al., 2011)

boca - Gk1

experimental knowledge based

(Guruharsha et al., 2011)

boca - Glt

experimental knowledge based

(Guruharsha et al., 2011)

boca - Gp210

experimental knowledge based

(Guruharsha et al., 2011)

boca - HnRNP-K

experimental knowledge based

(Guruharsha et al., 2011)

boca - Idh3a

experimental knowledge based

(Guruharsha et al., 2011)

boca - Larp4B

experimental knowledge based

(Guruharsha et al., 2011)

boca - LpR2

anti tag coimmunoprecipitation, anti tag western blot

(Culi et al., 2004)

boca - MED10

experimental knowledge based

(Guruharsha et al., 2011)

boca - MED11

experimental knowledge based

(Guruharsha et al., 2011)

boca - MED14

experimental knowledge based

(Guruharsha et al., 2011)

boca - MED15

experimental knowledge based

(Guruharsha et al., 2011)

boca - MED16

experimental knowledge based

(Guruharsha et al., 2011)

boca - MED17

experimental knowledge based

(Guruharsha et al., 2011)

boca - MED18

experimental knowledge based

(Guruharsha et al., 2011)

boca - MED20

experimental knowledge based

(Guruharsha et al., 2011)

boca - MED23

experimental knowledge based

(Guruharsha et al., 2011)

boca - MED27

experimental knowledge based

(Guruharsha et al., 2011)

boca - MED30

experimental knowledge based

(Guruharsha et al., 2011)

boca - MED4

experimental knowledge based

(Guruharsha et al., 2011)

boca - MED6

experimental knowledge based

(Guruharsha et al., 2011)

boca - MED7

experimental knowledge based

(Guruharsha et al., 2011)

boca - MED8

experimental knowledge based

(Guruharsha et al., 2011)

boca - Mpcp2

experimental knowledge based

(Guruharsha et al., 2011)

boca - Nacα

experimental knowledge based

(Guruharsha et al., 2011)

boca - Nup358

experimental knowledge based

(Guruharsha et al., 2011)

boca - Pa1

experimental knowledge based

(Guruharsha et al., 2011)

boca - Pi3K68D

experimental knowledge based

(Guruharsha et al., 2011)

boca - Pih1D1

experimental knowledge based

(Guruharsha et al., 2011)

boca - Psi

experimental knowledge based

(Guruharsha et al., 2011)

boca - Ptip

experimental knowledge based

(Guruharsha et al., 2011)

boca - RpLP0

experimental knowledge based

(Guruharsha et al., 2011)

boca - RpS10b

experimental knowledge based

(Guruharsha et al., 2011)

boca - RpS19a

experimental knowledge based

(Guruharsha et al., 2011)

boca - Samtor

experimental knowledge based

(Guruharsha et al., 2011)

boca - ScsβG

experimental knowledge based

(Guruharsha et al., 2011)

boca - Ser7

experimental knowledge based

(Guruharsha et al., 2011)

boca - SerRS

experimental knowledge based

(Guruharsha et al., 2011)

boca - TER94

experimental knowledge based

(Guruharsha et al., 2011)

boca - UQCR-6.4

experimental knowledge based

(Guruharsha et al., 2011)

boca - UQCR-C2

experimental knowledge based

(Guruharsha et al., 2011)

boca - Usp10

experimental knowledge based

(Guruharsha et al., 2011)

boca - bor

experimental knowledge based

(Guruharsha et al., 2011)

boca - dsh

experimental knowledge based

(Guruharsha et al., 2011)

boca - eIF3j

experimental knowledge based

(Guruharsha et al., 2011)

boca - ebi

experimental knowledge based

(Guruharsha et al., 2011)

boca - ix

experimental knowledge based

(Guruharsha et al., 2011)

boca - mor

experimental knowledge based

(Guruharsha et al., 2011)

boca - p23

experimental knowledge based

(Guruharsha et al., 2011)

boca - r

experimental knowledge based

(Guruharsha et al., 2011)

boca - scf

experimental knowledge based

(Guruharsha et al., 2011)

boca - vkg

experimental knowledge based

(Guruharsha et al., 2011)

boca - α-Spec

experimental knowledge based

(Guruharsha et al., 2011)

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Subunit Structure (UniProtKB)

Monomer (By similarity). Interacts with Arrow and Yolkless.

(UniProt, Q8T9B6 )

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0004132

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

48986

MIST (protein-protein) - An integrated Molecular Interaction Database

boca

Pathways

Gene Group - Pathway Membership (FlyBase)

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-56

Cytogenetic map

43D7-43D7

Sequence location

2R:7,565,873..7,566,738 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

43D7-43D7

Limits computationally determined from genome sequence between P{EP}CG1600^EP398 and P{PZ}scra⁰³⁴²⁷&P{EP}EP2179

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-56

(FlyBase, 2016)

2-56.7

(Comeron et al., 2012)

2-[57]

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (7)

Bloomington

28029

y¹ v¹; P{TRiP.JF02863}attP2

63461

w¹¹¹⁸; PBac{IT.GAL4}boca^0644-G4

4129

Dp(?;2)bw^D, boca¹ bw^D/CyO

78984

y¹ w^*; TI{CRIMIC.TG4.0}boca^{CR00684-TG4.0}/SM6a

Kyoto

107596

Dp(?;2)bw^D, boca¹ bw^D/CyO

VDRC

v108406

P{KK109195}VIE-260B

v13457

w¹¹¹⁸; P{GD5483}v13457

Genomic Clones (9)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (6)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequences

BDGP DGC clones

SD08653

Other clones

FI06486

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0004132

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

GM16274

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0004132

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

48986

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for database merge of

Source for merge of: CG30498 l(2)43Ea

(Culi, 2002.3.22)

Additional comments

Annotation CG1364 split into CG30499 and CG30498 (boca) in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Other Comments

boca is an essential component of the wg pathway but is more generally required for the activities of multiple LDL receptor family members.

(Culi and Mann, 2003)

boca is essential for proboscis development, and viability.

(Culi and Mann, 2002)

dsRNA causes embryos to develop into adults with reduced or absent proboscis but other fly body parts are apparently normal.

(Culi and Mann, 2002)

Origin and Etymology

Discoverer

Etymology

'boca' means mouth in Catalan.

(Culi and Mann, 2002)

Identification

External Crossreferences and Linkouts ( 26 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

48986

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q8T9B6

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0004132

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0004132

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

boca_1

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG30498

Flygut - An atlas of the Drosophila adult midgut

FBgn0004132

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

48986

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC000405

InterPro - A database of protein families, domains and functional sites

LRP chaperone MESD

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG30498

modMine - A data warehouse for the modENCODE project

FBgn0004132

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0004132

DRSC - Results frm RNAi screens

FBgn0004132

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0004132

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG30498-RA

FlyMine - An integrated database for Drosophila genomics

FBgn0004132

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

48986

MIST (protein-protein) - An integrated Molecular Interaction Database

boca

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

Boca

(Abrams et al., 2013, Beckett et al., 2013, Forrest et al., 2013, Mbodj et al., 2013, Tong et al., 2011, Chen et al., 2010, Kelkar and Dobberstein, 2009, Tan et al., 2009, Okajima et al., 2008, Tien et al., 2008, Tsuda et al., 2008, Lee and Cooley, 2007, Clevers, 2006, Wakefield and Tear, 2006)

CG1364

(Culi, 2002.3.22, BDGP Project Members, 2000-, Holdener, 2000.7.28)

CG30498

(Hosono et al., 2015, Cammarato et al., 2011, Kondylis et al., 2011, Keleman et al., 2009.8.5, Perkins et al., 2009, Pflieger et al., 2008, Qin et al., 2008)

boca

(Gene Disruption Project members, 2018-, Lee et al., 2018, Clandinin and Owens, 2016-, Japanese National Institute of Genetics, 2012.5.21, Khaliullina et al., 2009, Tan et al., 2009, Buszczak et al., 2007, Culi and Mann, 2003)

dmBoca

(Collins and Hendrickson, 2011)

l(2)43Ea

(Eeken et al., 2001, Heitzler et al., 1993)

Name Synonyms

Boca

(Kondylis et al., 2011, Texada et al., 2011)

boca

(Cammarato et al., 2011, Schlesinger and Shilo, 2005, Culi and Mann, 2002)

lethal(2)43Ea

Secondary FlyBase IDs

FBgn0033193
FBgn0050498

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (64)

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