l(2)43Eb
a cytoplasmic protein essential for somatic myoblast fusion - functions in stretching and outgrowth of circular visceral muscles - required for myoblast fusion - regulates actin cytoskeletal dynamics via modulating the stability of the WASp-Vrp1 complex.
Please see the JBrowse view of Dmel\blow for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.42
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.48
2.6 (northern blot)
644 (aa); 70 (kD observed)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\blow using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: reported as muscle system primordium
Comment: reported as muscle system primordium
blow transcripts are expressed in myoblasts just before and during myoblast fusion. Expression is first detected in late stage 10 embryos in 13 clusters of mesodermal cells, which may correspond to myoblast precursors. During stage 11 and 12, segmental stripes of fusing myoblasts are seen at the sites of the clusters. Expression peaks at early stage 13 and disappears by the end of stage 14.
JBrowse - Visual display of RNA-Seq signals
View Dmel\blow in JBrowse2-57
2-56.7
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
Gene expression is increased in response to the presence of two copies of Scer\GAL4hs.PB.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
blow is essential for myoblast fusion.
The blow gene is required for myoblast fusion.
Source for identity of: blow CG1363