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Gene Dmel\mts

General Information
Symbol	Dmel\mts	Species	D. melanogaster
Name	microtubule star	Annotation symbol	CG7109
Feature type	protein_coding_gene	FlyBase ID	FBgn0004177
Gene Model Status	Current	Stock availability	15 publicly available
Also Known As	PP2a, PP2a 28D, PP2A-C, PP2, PP2Ac, MTS/PP2A, dPP2A
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	28D1-28D2	Sequence location	2L:7,827,743..7,832,745 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene microtubule star is referred to in FlyBase by the symbol Dmel\mts (CG7109, FBgn0004177). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: phosphatase regulator activity; protein serine/threonine phosphatase activity. There is experimental evidence for 21 unique biological process terms, many of which group under: cellular component organization or biogenesis; cell cycle; biological regulation; cell cycle process; anatomical structure development; organelle organization; chromosome segregation; response to light stimulus; macromolecule modification; establishment or maintenance of cell polarity; multicellular organismal reproductive process. 29 alleles are reported. The phenotypes of these alleles are annotated with: eye; embryonic/larval brain; wing hair; embryonic/larval neuroblast. It has one annotated transcript and one annotated polypeptide. Protein features are: Metallophosphoesterase domain; Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of high expression. Peak expression observed within 00-18 hour embryonic stages, during late larval stages, during early pupal stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, adult crop, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval trachea, adult female reproductive system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult midgut, larval/adult salivary gland, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1640841_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of mts. Gene sequence location is 2L:7827743..7832745.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	References Knowles-Barley, 2011.8.24, BrainTrap expression curation. Wang et al., 2011, PLoS Genet. 7(8): e1002227
FB2012_01	References Müller et al., 2010, EMBO J. 29(19): 3344--3357 Su et al., 2011, Sci. Signal. 4(180): ra43 Rangone et al., 2011, PLoS Genet. 7(8): e1002225 Controlled Vocabulary Terms centrosome duplication Sequence features BKN60136 HFA03574 BKN60063 BKN28006
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 28D1-28D2   Limits computationally determined from genome sequence between P{EP}EP2178 and P{PZ}mts02496
Experimentally Determined Cytological Location
Cytogenetic map Notes References 28D1-28D2   (determined by in situ hybridisation)   (Spradling et al., 1999) 28D-28D   (determined by in situ hybridisation)   (Snaith et al., 1996) 28D1-28D2   (determined by in situ hybridisation)   (Wassarman et al., 1996) 28D2-28D4   (determined by in situ hybridisation)   (Mayer-Jaekel and Hemmings, 1995) 28D1-28D2     (BDGP Project Members, 1994-1999) 28D2-28D4   (determined by in situ hybridisation)   (Orgad et al., 1990)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\mts for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) mts-RA FBtr0079525  NM_057457   2178   309
Additional Transcript Data & Comments
Reported size (kB)	2.5, 1.6 (northern blot) (Mayer-Jaekel et al., 1992) 2.3, 1.5 (northern blot) (Orgad et al., 1990)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein mts-PA   FBpp0079148   35.5   309   4.97     NP_476805   AAF52567
Additional Polypeptide Data & Comments
Reported size (kDa)	309 (aa); 35.42 (kD predicted) (Orgad et al., 1990)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Metallophosphoesterase domain (IPR004843) Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase (IPR006186)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201617   AA264005   AA264326   AA391144   AA438543   AA438789   AA440920   AA567166   AA695313   AA696382   AA820727   AA820796   AA821000   AA942060   AA942428   AA948912   AA950630   AA950636   AA950857   AA990855   AE014134 AAF52567   AC004723   AC008328   AI108245   AI134422   AI134800   AI134809   AI258458   AI258699   AI259178   AI259231   AI294985   AI295405   AI296894   AI297293   AI405071   AI514825   AI515352   AI515924   AI517764   AI531017   AI546297   AQ073559   AW942828   AY058571 AAL13800   AY431529   AY439457   BE978204   BI162245   BI162246   BI165609   BI238045   BI238766   BI242683   BI354349   BI357059   BI357572   BI363803   BI364369   BI365367   BI365955   BI369212   BI375472   BI375909   BI481763   BI483486   BI484893   BI571068   BI580606   BI590713   BI591716   BI592981   BI605319   BI607882   BI607932   BI610067   BI613187   BI623687   BI626867   BI628132   BI637673   BI640664   BI641787   BP546261   BP549292   BP549293   BP550605   BP555794   BP555795   BP555983   BX033649   BX051433   BX051575   BX055549   BX059795   BX062834   CA804505   CA806211   CA807661   CA807786   CK132045   CK657344   CK662135   CL868585   CO152860   CO153347   CO153630   CO156367   CO156662   CO157098   CO177758   CO184758   CO264075   CO264750   CO269201   CO274930   CO276902   CO278324   CO279986   CO280631   CO281380   CO282684   CO283290   CO283460   CO284450   CO286265   CO293791   CO295272   CO296913   CO298436   CO299780   CO307068   CO307081   CO315066   CO317736   CO320600   CO323786   CO325490   CO328303   CO329919   CO332369   CO332763   CO334077   CZ467633   CZ487054   CZ488088   CZ488089   DN154215   EC051561   EC055097   EC061758   EC063443   EC063555   EC065544   EC066064   EC073002   EC073542   EC079245   EC082588   EC084808   EC090099   EC203551   EC204196   EC205167   EC205458   EC205667   EC206643   EC208862   EC209725   EC210005   EC210768   EC215629   EC220562   EC221255   EC224845   EC233020   EC233989   EC238678   EC238723   EC239381   EC246649   EC256621   EC261792   EC262129   EC264563   EC264965   EC265389   EC265814   EL884707   ES692827   ES694326   EV576490   EV579376   EV580056   EV582782   EV586140   EV586834   EV588486   EV592169   EV598103   EV598983   G01458   X55199 CAA38984   X78577 CAA55315
UniProtKB/Swiss-Prot	P23696
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage | early     (Mayer-Jaekel et al., 1992) embryonic stage & larval stage     (Mayer-Jaekel et al., 1992) embryonic stage & larval stage & adult stage     (Mayer-Jaekel et al., 1992) embryonic stage -- adult stage     (Orgad et al., 1990) radioisotope in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage | early   organism | ubiquitous   (Mayer-Jaekel et al., 1992) embryonic stage | late   gonad   (Mayer-Jaekel et al., 1992) ventral nerve cord   (Mayer-Jaekel et al., 1992) supraesophageal ganglion   (Mayer-Jaekel et al., 1992) embryonic stage   organism | ubiquitous   (Mayer-Jaekel et al., 1992) embryonic stage 9 -- 11   neuroblast   (Mayer-Jaekel et al., 1992) third instar larval stage   embryonic/larval salivary gland   (Mayer-Jaekel et al., 1992) embryonic/larval brain   (Mayer-Jaekel et al., 1992) imaginal disc   (Mayer-Jaekel et al., 1992) adult stage   adult brain   (Mayer-Jaekel et al., 1992) adult midgut   (Mayer-Jaekel et al., 1992) adult stage & oogenesis   nurse cell   (Mayer-Jaekel et al., 1992) oocyte   (Mayer-Jaekel et al., 1992)
Additional Descriptive Data
	The 2.3kb mts transcript is strongly expressed in early embryos and is reduced ~20fold in late embryos and larvae. (Mayer-Jaekel et al., 1992) The 1.5kb mts transcript is strongly expressed in eary embryos and decreases about 60% in late embryos and larvae. It is also detected in adults. (Mayer-Jaekel et al., 1992) The 2.3 and 1.5 kb mts transcripts are expressed throughout development. Expression is especially high in 0-4 hr embryos. (Orgad et al., 1990) Expression was observed in cryostat sections at several different stages of development. In adult females, basal levels of Pp2A-29B transcripts are detected in all tissues. High levels of expression are observed in the ovary in the nurse cells and oocytes. Slightly elevated levels are observed in the brain and the gut. In early embryos, transcripts are evenly distributed at high levels. In later embryos, the levels decline but slightly higher levels are seen in the developing CNS than in surrounding tissue. In third instar larvae, transcripts are enriched in the supraesophageal ganglion but are at very low levels in the neuropil. Elevated levels are observed in imaginal discs and salivary glands. In early embryos, in situ hybridization reveals uniform expression. Enrichment is observed in neuroblasts at germ band extension and in the ventral nerve cord and supraesophageal ganglion at later embryonic stages. In addition elevated levels are observed in the gonads. (Mayer-Jaekel et al., 1992)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
	Pp2A-29B and mts proteins show the same cytoplasmic localization in embryos and imaginal discs as the tws protein. In syncytial blastoderm embryos the protein is found in the cytoplasmic region surrounding the cortical layer of nuclei. The protein is cytoplasmic in pole cells. In cycle 14 embryos, the protein is located throughout the cytoplasm of interphase cells, and throughout the whole cell as it progresses through mitosis. In dividing third larval instar brain neuroblasts, the protein is detected in the cytoplasm of interphase and mitotic cells. (Mayer-Jaekel et al., 1994)
Marker for
Subcellular Localization
CV Term	cytoplasm (Mayer-Jaekel et al., 1994)
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0004177    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0004177 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of high expression. Peak expression observed within 00-18 hour embryonic stages, during late larval stages, during early pupal stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0004177 expression level Developmental Stage   Expression Level embryo 00-02hr    20771 embryo 02-04hr    28878 embryo 04-06hr    23806 embryo 06-08hr    22243 embryo 08-10hr    20872 embryo 10-12hr    19177 embryo 12-14hr    13549 embryo 14-16hr    10438 embryo 16-18hr    10269 embryo 18-20hr    9468 embryo 20-22hr    9456 embryo 22-24hr    9923 larva L1    8322 larva L2    8263 larva L3 12hr old    7722 larva L3 puffstage 1-2    8210 larva L3 puffstage 3-6    10508 larva L3 puffstage 7-9    13860 white prepupae new    12998 white prepupae 12hr    11739 white prepupae 24hr    13039 pupae 2d postWPP    9898 pupae 3d postWPP    7533 pupae 4d postWPP    9450 adult male 01day    5996 adult male 05day    5766 adult male 30day    5186 adult female 01day    9023 adult female 05day    12896 adult female 30day    12789 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (20771) embryo 02-04hr  (28878) embryo 04-06hr  (23806) embryo 06-08hr  (22243) embryo 08-10hr  (20872) embryo 10-12hr  (19177) embryo 12-14hr  (13549) embryo 14-16hr  (10438) embryo 16-18hr  (10269) embryo 18-20hr  (9468) embryo 20-22hr  (9456) embryo 22-24hr  (9923) larva L1  (8322) larva L2  (8263) larva L3 12hr old  (7722) larva L3 puffstage 1-2  (8210) larva L3 puffstage 3-6  (10508) larva L3 puffstage 7-9  (13860) white prepupae new  (12998) white prepupae 12hr  (11739) white prepupae 24hr  (13039) pupae 2d postWPP  (9898) pupae 3d postWPP  (7533) pupae 4d postWPP  (9450) adult male 01day  (5996) adult male 05day  (5766) adult male 30day  (5186) adult female 01day  (9023) adult female 05day  (12896) adult female 30day  (12789) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (20771) embryo 02-04hr  (28878) embryo 04-06hr  (23806) embryo 06-08hr  (22243) embryo 08-10hr  (20872) embryo 10-12hr  (19177) embryo 12-14hr  (13549) embryo 14-16hr  (10438) embryo 16-18hr  (10269) embryo 18-20hr  (9468) embryo 20-22hr  (9456) embryo 22-24hr  (9923) larva L1  (8322) larva L2  (8263) larva L3 12hr old  (7722) larva L3 puffstage 1-2  (8210) larva L3 puffstage 3-6  (10508) larva L3 puffstage 7-9  (13860) white prepupae new  (12998) white prepupae 12hr  (11739) white prepupae 24hr  (13039) pupae 2d postWPP  (9898) pupae 3d postWPP  (7533) pupae 4d postWPP  (9450) adult male 01day  (5996) adult male 05day  (5766) adult male 30day  (5186) adult female 01day  (9023) adult female 05day  (12896) adult female 30day  (12789) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (20771) embryo 02-04hr  (28878) embryo 04-06hr  (23806) embryo 06-08hr  (22243) embryo 08-10hr  (20872) embryo 10-12hr  (19177) embryo 12-14hr  (13549) embryo 14-16hr  10438 embryo 16-18hr  10269 embryo 18-20hr    9468 embryo 20-22hr    9456 embryo 22-24hr    9923 larva L1    8322 larva L2    8263 larva L3 12hr old    7722 larva L3 puffstage 1-2    8210 larva L3 puffstage 3-6  10508 larva L3 puffstage 7-9  (13860) white prepupae new  (12998) white prepupae 12hr  (11739) white prepupae 24hr  (13039) pupae 2d postWPP    9898 pupae 3d postWPP    7533 pupae 4d postWPP    9450 adult male 01day    5996 adult male 05day    5766 adult male 30day    5186 adult female 01day    9023 adult female 05day  (12896) adult female 30day  (12789) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    20771 embryo 02-04hr    28878 embryo 04-06hr    23806 embryo 06-08hr    22243 embryo 08-10hr    20872 embryo 10-12hr    19177 embryo 12-14hr    13549 embryo 14-16hr    10438 embryo 16-18hr    10269 embryo 18-20hr    9468 embryo 20-22hr    9456 embryo 22-24hr    9923 larva L1    8322 larva L2    8263 larva L3 12hr old    7722 larva L3 puffstage 1-2    8210 larva L3 puffstage 3-6    10508 larva L3 puffstage 7-9    13860 white prepupae new    12998 white prepupae 12hr    11739 white prepupae 24hr    13039 pupae 2d postWPP    9898 pupae 3d postWPP    7533 pupae 4d postWPP    9450 adult male 01day    5996 adult male 05day    5766 adult male 30day    5186 adult female 01day    9023 adult female 05day    12896 adult female 30day    12789 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0004177 expression level Developmental Stage   Expression Level embryo 00-02hr    20771 embryo 02-04hr    28878 embryo 04-06hr    23806 embryo 06-08hr    22243 embryo 08-10hr    20872 embryo 10-12hr    19177 embryo 12-14hr    13549 embryo 14-16hr    10438 embryo 16-18hr    10269 embryo 18-20hr    9468 embryo 20-22hr    9456 embryo 22-24hr    9923 larva L1    8322 larva L2    8263 larva L3 12hr old    7722 larva L3 puffstage 1-2    8210 larva L3 puffstage 3-6    10508 larva L3 puffstage 7-9    13860 white prepupae new    12998 white prepupae 12hr    11739 white prepupae 24hr    13039 pupae 2d postWPP    9898 pupae 3d postWPP    7533 pupae 4d postWPP    9450 adult male 01day    5996 adult male 05day    5766 adult male 30day    5186 adult female 01day    9023 adult female 05day    12896 adult female 30day    12789 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (20771) embryo 02-04hr  (28878) embryo 04-06hr  (23806) embryo 06-08hr  (22243) embryo 08-10hr  (20872) embryo 10-12hr  (19177) embryo 12-14hr  (13549) embryo 14-16hr  (10438) embryo 16-18hr  (10269) embryo 18-20hr  (9468) embryo 20-22hr  (9456) embryo 22-24hr  (9923) larva L1  (8322) larva L2  (8263) larva L3 12hr old  (7722) larva L3 puffstage 1-2  (8210) larva L3 puffstage 3-6  (10508) larva L3 puffstage 7-9  (13860) white prepupae new  (12998) white prepupae 12hr  (11739) white prepupae 24hr  (13039) pupae 2d postWPP  (9898) pupae 3d postWPP  (7533) pupae 4d postWPP  (9450) adult male 01day  (5996) adult male 05day  (5766) adult male 30day  (5186) adult female 01day  (9023) adult female 05day  (12896) adult female 30day  (12789) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (20771) embryo 02-04hr  (28878) embryo 04-06hr  (23806) embryo 06-08hr  (22243) embryo 08-10hr  (20872) embryo 10-12hr  (19177) embryo 12-14hr  (13549) embryo 14-16hr  (10438) embryo 16-18hr  (10269) embryo 18-20hr  (9468) embryo 20-22hr  (9456) embryo 22-24hr  (9923) larva L1  (8322) larva L2  (8263) larva L3 12hr old  (7722) larva L3 puffstage 1-2  (8210) larva L3 puffstage 3-6  (10508) larva L3 puffstage 7-9  (13860) white prepupae new  (12998) white prepupae 12hr  (11739) white prepupae 24hr  (13039) pupae 2d postWPP  (9898) pupae 3d postWPP  (7533) pupae 4d postWPP  (9450) adult male 01day  (5996) adult male 05day  (5766) adult male 30day  (5186) adult female 01day  (9023) adult female 05day  (12896) adult female 30day  (12789) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (20771) embryo 02-04hr  (28878) embryo 04-06hr  (23806) embryo 06-08hr  (22243) embryo 08-10hr  (20872) embryo 10-12hr  19177 embryo 12-14hr  13549 embryo 14-16hr  10438 embryo 16-18hr  10269 embryo 18-20hr    9468 embryo 20-22hr    9456 embryo 22-24hr    9923 larva L1    8322 larva L2    8263 larva L3 12hr old    7722 larva L3 puffstage 1-2    8210 larva L3 puffstage 3-6  10508 larva L3 puffstage 7-9  13860 white prepupae new  12998 white prepupae 12hr  11739 white prepupae 24hr  13039 pupae 2d postWPP    9898 pupae 3d postWPP    7533 pupae 4d postWPP    9450 adult male 01day    5996 adult male 05day    5766 adult male 30day    5186 adult female 01day    9023 adult female 05day  12896 adult female 30day  12789 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    20771 embryo 02-04hr    28878 embryo 04-06hr    23806 embryo 06-08hr    22243 embryo 08-10hr    20872 embryo 10-12hr    19177 embryo 12-14hr    13549 embryo 14-16hr    10438 embryo 16-18hr    10269 embryo 18-20hr    9468 embryo 20-22hr    9456 embryo 22-24hr    9923 larva L1    8322 larva L2    8263 larva L3 12hr old    7722 larva L3 puffstage 1-2    8210 larva L3 puffstage 3-6    10508 larva L3 puffstage 7-9    13860 white prepupae new    12998 white prepupae 12hr    11739 white prepupae 24hr    13039 pupae 2d postWPP    9898 pupae 3d postWPP    7533 pupae 4d postWPP    9450 adult male 01day    5996 adult male 05day    5766 adult male 30day    5186 adult female 01day    9023 adult female 05day    12896 adult female 30day    12789 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0004177    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0004177 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, adult crop, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval trachea, adult female reproductive system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult midgut, larval/adult salivary gland, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0004177 expression level Tissue   Expression Level Larval Central Nervous System    943.2 Larval Midgut    430.6 Larval Hindgut    677.2 Larval Malpighian Tubules    842.6 Larval Fat Body    795.1 Larval Salivary Gland    436.8 Larval Trachea    700.125 Larval Carcass    326.475 Adult Head    488.1 Adult Eye    846.075 Adult Brain    921.9 Adult Thoracic-Abdominal Ganglion    809 Adult Crop    672.7 Adult Midgut    342.1 Adult Hindgut    570.1 Adult Malpighian Tubules    749.1 Adult Fat Body    528.8 Adult Salivary Gland    406.9 Adult Heart    753.775 Adult VirginFemale Spermatheca    815.7 Adult InseminatedFemale Spermatheca    701.1 Adult Ovary    664.9 Adult Testis    170.9 Adult Male Accessory Gland    407.1 Adult Carcass    443.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (943.2) Larval Midgut    430.6 Larval Hindgut  (677.2) Larval Malpighian Tubules  (842.6) Larval Fat Body  (795.1) Larval Salivary Gland    436.8 Larval Trachea  (700.125) Larval Carcass    326.475 Adult Head    488.1 Adult Eye  (846.075) Adult Brain  (921.9) Adult Thoracic-Abdominal Ganglion  (809) Adult Crop  (672.7) Adult Midgut    342.1 Adult Hindgut  (570.1) Adult Malpighian Tubules  (749.1) Adult Fat Body  528.8 Adult Salivary Gland    406.9 Adult Heart  (753.775) Adult VirginFemale Spermatheca  (815.7) Adult InseminatedFemale Spermatheca  (701.1) Adult Ovary  (664.9) Adult Testis    170.9 Adult Male Accessory Gland    407.1 Adult Carcass    443.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    943.2 Larval Midgut    430.6 Larval Hindgut    677.2 Larval Malpighian Tubules    842.6 Larval Fat Body    795.1 Larval Salivary Gland    436.8 Larval Trachea    700.125 Larval Carcass    326.475 Adult Head    488.1 Adult Eye    846.075 Adult Brain    921.9 Adult Thoracic-Abdominal Ganglion    809 Adult Crop    672.7 Adult Midgut    342.1 Adult Hindgut    570.1 Adult Malpighian Tubules    749.1 Adult Fat Body    528.8 Adult Salivary Gland    406.9 Adult Heart    753.775 Adult VirginFemale Spermatheca    815.7 Adult InseminatedFemale Spermatheca    701.1 Adult Ovary    664.9 Adult Testis    170.9 Adult Male Accessory Gland    407.1 Adult Carcass    443.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    943.2 Larval Midgut    430.6 Larval Hindgut    677.2 Larval Malpighian Tubules    842.6 Larval Fat Body    795.1 Larval Salivary Gland    436.8 Larval Trachea    700.125 Larval Carcass    326.475 Adult Head    488.1 Adult Eye    846.075 Adult Brain    921.9 Adult Thoracic-Abdominal Ganglion    809 Adult Crop    672.7 Adult Midgut    342.1 Adult Hindgut    570.1 Adult Malpighian Tubules    749.1 Adult Fat Body    528.8 Adult Salivary Gland    406.9 Adult Heart    753.775 Adult VirginFemale Spermatheca    815.7 Adult InseminatedFemale Spermatheca    701.1 Adult Ovary    664.9 Adult Testis    170.9 Adult Male Accessory Gland    407.1 Adult Carcass    443.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0004177 expression level Tissue   Expression Level Larval Central Nervous System    943.2 Larval Midgut    430.6 Larval Hindgut    677.2 Larval Malpighian Tubules    842.6 Larval Fat Body    795.1 Larval Salivary Gland    436.8 Larval Trachea    700.125 Larval Carcass    326.475 Adult Head    488.1 Adult Eye    846.075 Adult Brain    921.9 Adult Thoracic-Abdominal Ganglion    809 Adult Crop    672.7 Adult Midgut    342.1 Adult Hindgut    570.1 Adult Malpighian Tubules    749.1 Adult Fat Body    528.8 Adult Salivary Gland    406.9 Adult Heart    753.775 Adult VirginFemale Spermatheca    815.7 Adult InseminatedFemale Spermatheca    701.1 Adult Ovary    664.9 Adult Testis    170.9 Adult Male Accessory Gland    407.1 Adult Carcass    443.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (943.2) Larval Midgut    430.6 Larval Hindgut  677.2 Larval Malpighian Tubules  (842.6) Larval Fat Body  795.1 Larval Salivary Gland    436.8 Larval Trachea  700.125 Larval Carcass    326.475 Adult Head    488.1 Adult Eye  (846.075) Adult Brain  (921.9) Adult Thoracic-Abdominal Ganglion  809 Adult Crop  672.7 Adult Midgut    342.1 Adult Hindgut  570.1 Adult Malpighian Tubules  749.1 Adult Fat Body  528.8 Adult Salivary Gland    406.9 Adult Heart  753.775 Adult VirginFemale Spermatheca  (815.7) Adult InseminatedFemale Spermatheca  701.1 Adult Ovary  664.9 Adult Testis    170.9 Adult Male Accessory Gland    407.1 Adult Carcass    443.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    943.2 Larval Midgut    430.6 Larval Hindgut    677.2 Larval Malpighian Tubules    842.6 Larval Fat Body    795.1 Larval Salivary Gland    436.8 Larval Trachea    700.125 Larval Carcass    326.475 Adult Head    488.1 Adult Eye    846.075 Adult Brain    921.9 Adult Thoracic-Abdominal Ganglion    809 Adult Crop    672.7 Adult Midgut    342.1 Adult Hindgut    570.1 Adult Malpighian Tubules    749.1 Adult Fat Body    528.8 Adult Salivary Gland    406.9 Adult Heart    753.775 Adult VirginFemale Spermatheca    815.7 Adult InseminatedFemale Spermatheca    701.1 Adult Ovary    664.9 Adult Testis    170.9 Adult Male Accessory Gland    407.1 Adult Carcass    443.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    943.2 Larval Midgut    430.6 Larval Hindgut    677.2 Larval Malpighian Tubules    842.6 Larval Fat Body    795.1 Larval Salivary Gland    436.8 Larval Trachea    700.125 Larval Carcass    326.475 Adult Head    488.1 Adult Eye    846.075 Adult Brain    921.9 Adult Thoracic-Abdominal Ganglion    809 Adult Crop    672.7 Adult Midgut    342.1 Adult Hindgut    570.1 Adult Malpighian Tubules    749.1 Adult Fat Body    528.8 Adult Salivary Gland    406.9 Adult Heart    753.775 Adult VirginFemale Spermatheca    815.7 Adult InseminatedFemale Spermatheca    701.1 Adult Ovary    664.9 Adult Testis    170.9 Adult Male Accessory Gland    407.1 Adult Carcass    443.9 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    488.1   NA  Eye    846.075   NA  Brain    921.9   943.2  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    809   NA  Crop    672.7   430.6  Midgut    342.1   677.2  Hindgut    570.1   842.6  Malpighian Tubules    749.1   795.1  Fat Body    528.8   436.8  Salivary Gland    406.9   NA  Heart    753.775   700.125  Trachea    NA   NA  VirginFemale Spermatheca    815.7   NA  InseminatedFemale Spermatheca    701.1   NA  Ovary    664.9   NA  Testis    170.9   NA  Male Accessory Gland    407.1   326.475  Carcass    443.9 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_30
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004177 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7109-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for mts Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | embryonic stage | recessive mts02496 mts05559 mtsk06009 mtsk09822 mtsk12502 mtsk16501 mtsXE-2202 mtsXE-2258 lethal | pupal stage, with Scer\GAL4pnr-MD237 mtsGD12133 lethal | pupal stage | recessive mts299 lethal | recessive mts02496 mts05559 mtss5286 mtsXE-2202 mtsXE-2258 viable mtsEY12638 Sterility Allele fertile mtsEY12638 Other Phenotypes Allele increased cell number, with Scer\GAL4Act.PU mtsdn181.Scer\UAS locomotor rhythm defective, with Scer\GAL4P2.4.Pdf mtsdn181.Scer\UAS mtsScer\UAS.cHa locomotor rhythm defective, with Scer\GAL4tim.PE mtsdn181.Scer\UAS mtsScer\UAS.cHa mitotic cell cycle defective mtsk09822 neuroanatomy defective, with Scer\GAL4elav.PLu mtsdn181.Scer\UAS neuroanatomy defective (with mts299) mtsXE-2258 neuroanatomy defective (with mtsXE-2258) mts299 neuroanatomy defective | larval stage mts299 neuroanatomy defective | larval stage, with Scer\GAL41407 mtsGD12133 neuroanatomy defective | larval stage, with Scer\GAL4ase.neuro mtsGD12133 neuroanatomy defective | larval stage (with mts299) mtss5286 neuroanatomy defective | larval stage (with mtss5286) mts299 planar polarity defective, with Scer\GAL4ptc-559.1 mtsdn165.Scer\UAS mtsdn181.Scer\UAS mtsdn214.Scer\UAS visible, with Scer\GAL4GMR.PF mtsDN.Scer\UAS Phenotype manifest in Allele bouton & neuromuscular junction | larval stage, with Scer\GAL4elav.PLu mtsdn181.Scer\UAS embryonic/larval brain mts299 embryonic/larval brain, with Scer\GAL41407 mtsGD12133 embryonic/larval brain, with Scer\GAL4ase.neuro mtsGD12133 embryonic/larval brain (with mts299) mtss5286 embryonic/larval brain (with mtss5286) mts299 embryonic/larval neuroblast, with Scer\GAL4Act.PU mtsdn181.Scer\UAS eye, with Scer\GAL4GMR.PF mtsDN.Scer\UAS microtubule & neuromuscular junction | larval stage, with Scer\GAL4elav.PLu mtsdn181.Scer\UAS neuroblast | supernumerary mts299 neuroblast | supernumerary, with Scer\GAL41407 mtsGD12133 neuroblast | supernumerary, with Scer\GAL4ase.neuro mtsGD12133 neuroblast | supernumerary (with mts299) mtsXE-2258 mtss5286 neuroblast | supernumerary (with mtss5286) mts299 neuroblast | supernumerary (with mtsXE-2258) mts299 wing hair, with Scer\GAL4ptc-559.1 mtsdn165.Scer\UAS mtsdn181.Scer\UAS mtsdn214.Scer\UAS wing hair | supernumerary, with Scer\GAL4ptc-559.1 mtsScer\UAS.cHa
Classical Alleles ( 18 )
For All Classical Alleles Show
Allele of mts Class Mutagen Stocks Known lesion mtsk12502 P-element activity 3 -- mtss5286 P-element activity 2 -- mts02496 P-element activity 1 Yes mtsc02035 piggyBac transposase 1 -- mtsEY12638 P-element activity 1 -- mtsk16501 P-element activity 1 -- mtsNP0662 1 -- mtsXE-2258 X ray 1 Yes mts05559 P-element activity 0 -- mts299 hypomorphic allele - genetic evidence 0 Yes mtsCPTI003684 piggyBac transposase 0 Yes mtsEP2405 P-element activity 0 -- mtsf04519 piggyBac transposase 0 -- mtsf05498 piggyBac transposase 0 -- mtsk06009 P-element activity 0 -- mtsk09822 P-element activity 0 Yes mtsunspecified 0 -- mtsXE-2202 X ray 0 Yes
Alleles Carried on Transgenic Constructs ( 11 )
For All Alleles Carried on Transgenic Constructs Show
Allele of mts Class Mutagen Stocks Known lesion mtsGD12133 in vitro construct - RNAi in vitro construct - regulatory fusion 3 Yes mtsJF02805 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes mtsAct5C.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes mtsDN.Scer\UAS in vitro construct - site directed mutagenesis in vitro construct - regulatory fusion 0 Yes mtsdn165.Scer\UAS in vitro construct - regulatory fusion 0 Yes mtsdn181.Scer\UAS in vitro construct - regulatory fusion 0 Yes mtsdn214.Scer\UAS in vitro construct - regulatory fusion 0 Yes mtsdsRNA.1-690 in vitro construct - RNAi 0 Yes mtsScer\UAS.cHa in vitro construct - regulatory fusion 0 Yes mtsScer\UAS.cUa in vitro construct - regulatory fusion 0 Yes mtsScer\UAS.T:Hsap\MYC in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)28D-15 (Snaith et al., 1996) Df(2L)28D-19 (Snaith et al., 1996) Df(2L)28D-55 (Snaith et al., 1996) Df(2L)BSC41 (Deal et al., 2003.9.17, Casso et al., 2008) Df(2L)BSC142 (Christensen and Cook, 2006.3.8) Df(2L)BSC190 (Christensen and Cook, 2006.8.29) Df(2L)BSC191 (Christensen and Cook, 2006.8.29) Df(2L)BSC233 (Christensen and Cook, 2006.12.5) Df(2L)Dwee-δ5 (BDGP Project Members, 1994-1999) Df(2L)ED12527 (Ramel, 2007) Df(2L)Exel7032 (Ryder, 2004.4.26) Df(2L)XE-52 (Wassarman et al., 1996) Df(2L)XE-715 (Wassarman et al., 1996) Df(2L)XE-2267 (Wassarman et al., 1996) Df(2L)XE-2269 (Wassarman et al., 1996) Df(2L)XE-2387 (Wassarman et al., 1996) Df(2L)XE-2519 (Wassarman et al., 1996) Df(2L)XE-2668 (Wassarman et al., 1996) Df(2L)XE-2750 (Spradling et al., 1999, BDGP Project Members, 1994-1999, Wassarman et al., 1996) Df(2L)XE-2794 (Wassarman et al., 1996) Df(2L)XE-2860 (Wassarman et al., 1996) Df(2L)XE-3103 (Wassarman et al., 1996) Df(2L)XE-3494 (Wassarman et al., 1996) Df(2L)XE-3595 (Wassarman et al., 1996) Df(2L)XE-3696 (Wassarman et al., 1996) Df(2L)XE-3781 (Wassarman et al., 1996) Df(2L)XE-3801 (BDGP Project Members, 1994-1999, Wassarman et al., 1996, Casso et al., 2008) Df(2L)XE-3841 (Wassarman et al., 1996) Df(2R)Kr10 (BDGP Project Members, 1994-1999)
Not disrupted in	Df(2L)J-H (Spradling et al., 1999, BDGP Project Members, 1994-1999) Df(2L)spd (Spradling et al., 1999, BDGP Project Members, 1994-1999) Df(2L)Trf-C6R31 (BDGP Project Members, 1994-1999) Df(2R)M60E (BDGP Project Members, 1994-1999)
Partially disrupted in	Df(2L)RACK1-mts (Kadrmas et al., 2007)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD12133} NA P{TRiP.JF02805} NA P{UAS-mts.dn165} NA P{UAS-mts.dn181} NA P{UAS-mts.dn214} NA P{UAS-mts.DN} NA P{UAS-mts.H} NA P{UAS-mts.U} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}l(2)SH0298SH0298 No P{lacW}mtsk06009 No P{lacW}mtsk09822 No P{lacW}mtsk12502 No P{lacW}mtsk16501 No P{lacW}mtss5286 No P{PZ}mts02496 No P{PZ}mts05559 No insertion of mobile activating element P{EP}mtsEP2405 NA P{EPgy2}mtsEY12638 NA miscellaneous insertions PBac{768.FSVS-0}mtsCPTI003684 NA PBac{PB}mtsc02035 NA PBac{WH}mtsf04519 NA PBac{WH}mtsf05498 NA insertion of enhancer trap binary system P{GawB}mtsNP0662 No
Gene Ontology: Function, Process & Cellular Component ( 25 unique terms )
Terms Based on Experimental Evidence ( 24 terms )
Molecular Function
CV term Evidence References
phosphatase regulator activity inferred from direct assay (Wang et al., 2008) protein serine/threonine phosphatase activity inferred from mutant phenotype (Snaith et al., 1996)
Biological Process
CV term Evidence References
actin filament organization inferred from mutant phenotype (Kiger et al., 2003) asymmetric neuroblast division inferred from genetic interaction with l(2)gl (Ogawa et al., 2009) inferred from genetic interaction with par-6 (Ogawa et al., 2009) canonical Wnt receptor signaling pathway inferred from mutant phenotype (Zhang et al., 2009) cell adhesion inferred from mutant phenotype (Kiger et al., 2003) centrosome cycle inferred from mutant phenotype (Chen et al., 2007) centrosome duplication inferred from mutant phenotype (Müller et al., 2010) chromosome segregation inferred from mutant phenotype (Chen et al., 2007) establishment of epithelial cell polarity inferred from expression pattern (Ogawa et al., 2009) microtubule cytoskeleton organization inferred from mutant phenotype (Viquez et al., 2006) mitosis inferred from mutant phenotype (Snaith et al., 1996) mitotic cell cycle inferred from mutant phenotype (Chen et al., 2007) negative regulation of neuroblast proliferation inferred from mutant phenotype (Wang et al., 2009) oogenesis inferred from mutant phenotype (Wassarman et al., 1996) phagocytosis, engulfment inferred from mutant phenotype (Stroschein-Stevenson et al., 2006) positive regulation of smoothened signaling pathway inferred from genetic interaction with hh (Casso et al., 2008) inferred from genetic interaction with smo (Casso et al., 2008) protein dephosphorylation inferred from mutant phenotype (Snaith et al., 1996) R7 cell fate commitment inferred from genetic interaction with Ras85D (Wassarman et al., 1996) regulation of cell shape inferred from mutant phenotype (Kiger et al., 2003) response to light stimulus inferred from genetic interaction with inaC (Wang et al., 2008) spindle assembly inferred from mutant phenotype (Chen et al., 2007) spindle organization inferred from mutant phenotype (Snaith et al., 1996)
Cellular Component
CV term Evidence References
cytoplasm inferred from direct assay (Chabu and Doe, 2009, Mayer-Jaekel et al., 1994)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
protein serine/threonine phosphatase activity inferred from sequence or structural similarity (Mayer-Jaekel et al., 1992) non-traceable author statement (Swiss-Prot Project Members, 1991.11.1, Morrison et al., 2000)
Biological Process
CV term Evidence References
protein dephosphorylation non-traceable author statement (Morrison et al., 2000, Swiss-Prot Project Members, 1991.11.1)
Cellular Component
CV term Evidence References
protein phosphatase type 2A complex inferred from sequence or structural similarity (Mayer-Jaekel et al., 1992)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions mts allele Gene References mtsk09822 png (Lee et al., 2001) mtss5286 png (Lee et al., 2001) mtsXE-2202 Dsor1 (Karim et al., 1996) phl (Karim et al., 1996) phl::tor (Karim et al., 1996) Ras85D (Wassarman et al., 1996, Karim et al., 1996) wdb (Hannus et al., 2002) mtsXE-2258 Dsor1 (Karim et al., 1996) phl (Wassarman et al., 1996, Karim et al., 1996) phl::tor (Wassarman et al., 1996, Karim et al., 1996) Ras85D (Wassarman et al., 1996, Karim et al., 1996) wdb (Hannus et al., 2002)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 70018 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0004177 DroID - A comprehensive database of gene and protein interactions. • FBgn0004177 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 45959
Orthologs
Genome-wide drosophilid orthologs	Dana\GF21831 Dere\GG10501 Dgri\GH10208 Dmoj\GI14963 Dper\GL18646 Dpse\GA25737 Dsec\GM16609 Dsim\GD23492 Dvir\GJ17232 Dwil\GK23721 Dyak\GE14639
Curated drosophilid orthologs
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL013068-PA Aedes aegypti (mosquito) AGAP010172-PA Anopheles gambiae (mosquito) XP_623105.1 Apis mellifera (honey bee) NP_001119644.1 Acyrthosiphon pisum (pea aphid) At1g10430.1 Arabidopsis thaliana (wall cress) 18460 Batrachochytrium dendrobatidis (chytrid fungus) 123893 Branchiostoma floridae (lancelet) BGIBMGA007460-PA Bombyx mori (silk worm) ENSBTAP00000012182 Bos taurus (bovine) CAL0000149 Candida albicans (a form of yeast) CN19062 Caenorhabditis brenneri (small nematode) CBP01534 Caenorhabditis briggsae (nematode) CE10074 Caenorhabditis elegans (worm) ENSCAFP00000009667 Canis familiaris (dog) CAGL0I03938g Candida glabrata (haploid yeast) Chro.70100 Cryptosporidium hominis (obligate parasite) JA08511 Caenorhabditis japonica (nematode) CML332C Cyanidioschyzon merolae (red alga) cn05366 Cryptococcus neoformans (yeast-like fungus) cgd7_810 Cryptosporidium parvum (protozoan parasite) CPIJ013232 Culex pipens (mosquito) ENSCPOP00000004648 Cavia porcellus (guinea pig) 193562 Chlamidomonas reinhardtii (green alga) RP42020 Caenorhabditis remanei (nematode) ENSCSAVP00000001589 Ciona savignyi (sedentary tunicate) 227677 Capitella spl (polychaete worm) DDB0191299 Dictyostelium discoideum (amoeba) DEHA2D15290g Debaryomyces Hansenii (yeast) ENSDARP00000062145 Danio rerio (zebra fish) ENSECAP00000009288 Equus caballus (horse) XP_656214 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000027616 Gymnopilus aculeatus (mushroom) ENSGALP00000010423 Gallus gallus (chicken) GL50803_5010 Giardia lamblia (flagellated protozoan) 98479 Hypsipyla robusta (cedar shoot borer) ENSP00000384493 Homo sapiens (human) ISCW014549-PA Ixodes scapularis (deer tick) KLLA0F05357g Kluyveromyces lactis (yeast) 184125 Lottia gigantea (owl limpet) LmjF25.1320 Leishmania major (virus) 20632 Monocosta brevicollis (choanoflagellate) ENSMODP00000017725 Monodelphis domestica (gray opossum) ENSMODP00000023713 Monodelphis domestica (gray opossum) ENSMMUP00000027404 Macaca mulatta (rhesus monkey) ENSMUSP00000009774 Mus musculus (house mouse) 195622 Nematostella vectensis (starlet anemone) ENSOANP00000021328 Ornithorynchus anatinus (platypus) ENSORLP00000001162 Oryzias latipes (japanese killifish) LOC_Os06g37660.1 Oryza sativa (asian rice) 18276 Ostreococcus tauri (green alga) PHUM005300-PA Pediculus humanus (human body louse) PP20779 Pristionchus pacificus (nematode) 226377 Physcomitrella patens (moss) ENSPPYP00000020727 Pongo pygmaeus (orangutan) 71251 Phytophthora ramorum (sudden oak death pathogen) 109378 Phytophthora sojae (root rot pathogen) 833487 Populus trichocarpa (black cottonwood) ENSPTRP00000034477 Pan troglodytes (chimpanzee) ENSRNOP00000020663 Rattus norvegicus (norway rat) 4869567 Sorghum bicolor (sorghum) YDL188C Saccharomyces cerevisiae (budding yeast) Smp_165490 Schistosoma mansoni (trematode parasite) SPBC16H5.07c Schizosaccharomyces pombe (fission yeast) XP_001178176.1 Strongylocentrotus purpuratus (purple sea urchin) 63380 Trichoplax adhaerens (metazoa) TA15515 Theileria annulata (apicomplexan parasite) XP_973546.1 Tribolium castaneum (red flour beetle) Tc00.1047053509453.50 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053511881.20 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000019184 Tetraodon nigroviridis (green spotted pufferfish) TP02_0853 Theileria parva (parasitic protozoan) 1585 Thalassiosira pseudonana (marine diatom) ENSTRUP00000019973 Takifugu rubripes (pufferfish Takifugu) 3732.m00070 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000035093 Xenopus tropicalis (frog) YALI0F14069g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB17228 NV13733 LH13436 ISCW014549 FBgn0232234 FBgn0225683 FBgn0204408 FBgn0194871 FBgn0171522 JGI_V11_68048 FBgn0247114 FBgn0156247 FBgn0137714 FBgn0117689 FBgn0102809 FBgn0098831 CPIJ013232 BGIBMGA007460 ACYPI000060 GB14863 AGAP010172 AAEL013068 PHUM269020 GLEAN_05366
Stocks & Reagents
Stocks Listed in FlyBase ( 15 )
Bloomington	5684 mtsXE-2258/CyO, P{sevRas1.V12}FK1 27723 y1 v1; P{TRiP.JF02805}attP2 11193 P{PZ}mts02496 cn1/CyO; ry506 20763 y1 w67c23; P{EPgy2}mtsEY12638 10464 y1 w67c23; P{lacW}mtss5286/CyO
Harvard	- PBac{PB}mtsc02035
Kyoto	103701 w*; P{GawB}mtsNP0662 / CyO 102837 y1 w67c23 ; P{lacW}mtsk12502 / CyO 103008 y1 w67c23 ; P{lacW}mtsk16501 / CyO
VDRC	v35171 w1118; P{GD12133}v35171 v35172 w1118; P{GD12133}v35172 v41924 w1118; P{GD12133}v41924/CyO
	More stocks available...
Genomic Clones ( 3 )
	BACR09A04 BACR16J09 BACR31D05 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 178 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD26077
Other clones	DPiM_LD26077
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH07034 GH11886 GH12349 GH12361 GH24983 GH28822 GM01183 GM02581 GM07579 GM22437 LD04712 LD07316 LD08031 LD09226 LD12341 LD12727 LD13145 LD24587 LD24683 LD24970 LD26646 LD27606 LD30507 LD30519 LD31008 LD34788 LD41242 LD41631 LD47134 LD47839 LP01664 LP01952 LP02530 LP02594 LP08486 LP09023 LP11011 LP11560 LP13264 LP22129 LP23555 RE05537 RE34414 RE40081 RE41832 RE43407 RE44092 RE48751 RE49462 RE50651 RE51362 RE55331 RE63293 RE63815 RE64364 RE66388 RE68068 RE74822 RH04370 RH05878 RH06586 RH10831 RH11858 RH12036 RH14939 RH42286 RH56012 RH56449 RH67948 RH70904 SD01871 SD19732 SD23627 SD25410
Other clones	1364 17393 29319 30016 31405 35012 38939 41552 42320 43798 44915 64864 67578 70855 81925 119375 147820 147852 164513 164727 165349 167328 181643 191335 240959 273563 275369 283448 287728 295208 296538 522309 528094 bs75d07 CK01.40C.C8 CK01.113D.F3 CK01.123B.F8 CK01.142D.F12 Dmel_dig_009038_0689_2659 Dmel_dig_012846_0638_3188 Dmel_dig_016727_0600_0980 Dmel_dig_017599_0626_3311 Dmel_dig_019557_0685_0616 Dmel_neb_010306_0885_1925 Dmel_neb_012627_0671_3238 Dmel_neb_013442_0169_0475 Dmel_neb_014899_0827_2082 Dmel_neb_015006_0184_3159 EC28525 EC051561 EC055097 EC256621 EK054223 EK062303 EK093856 EK115956 EK122347 EK129751 EK137332 EK140244 EK152140 EK154519 EK157019 EK160953 EK162804 EK163330 EK166108 EK173013 EK176525 EK191454 EK196637 EK198639 EK204836 EK209303 EK215419 EK238915 EK253437 EK253461 EK268934 EK286454 EK294149 EK303262 EK304504 EK308826 EN00618 EN01812 EN02460 EN07928 EN08524 EN09931 EP08932 ESG012b.E21.2_F07 ESG018d.E21_F03 ESG019c.E21_D06 ESG0113d.B21_H08 FGH104E06 FGM004G02 FGM208A12 FGM237B10 FGM238E05 IP15962 RE01616
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0004177 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 45959
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: mts CG7109 (Bayraktaroglu, 2000.4.13)
Additional comments
Other Comments
	mts is required for efficient recruitment of pericentriolar material. (Dobbelaere et al., 2008) dsRNA directed against this gene has been used in a screen for genes required for constitutive protein secretion. (Bard et al., 2006) S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells. (Stroschein-Stevenson et al., 2006) Identified as a potential component of the hh signalling pathway in a genome-wide RNAi screen. dsRNA made from templates generated with primers directed affects the extent of expression of a hh signaling reporter construct in Clone 8 cells. (Nybakken et al., 2005) RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in Kc167 cells: change from round to spindle-shaped, with the formation of F-actin puncta and microtubule extensions. Alterations of cell shape are also evident in S2R+ cells; cells become round and detached. (Kiger et al., 2003) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) Identification: Enhancer trap expression pattern survey for loci expressed in the ring gland. (Harvie et al., 1998) Lack of mts causes a block in mitosis and uncouples the centrosome cycle from the nuclear cycle and prevents the attachment of microtubules to the kinetochore. (Snaith et al., 1996) Encodes the catalytic subunit of PP2A. (Wassarman et al., 1996) The mts product positively and negatively regulates Ras85D-mediated photoreceptor development. (Wassarman et al., 1996) A screen to identify mutations affecting the Ras85D signalling pathway identified alleles of phl, Dsor1, rl, aop, βggt-I, mts, ksr and phyl. (Therrien et al., 1995) mts has been molecularly cloned and developmental expression patterns examined. (Mayer-Jaekel et al., 1992) A mts cDNA has been cloned and sequenced. (Orgad et al., 1990)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057457 RefSeq (Proteins) • NP_476805 DDBJ / EMBL / GenBank • AA438543 AA942060 AAF52567 AAL13800 AC004723 AC008328 AQ073559 AW942828 AY058571 CAA38984 CAA55315 CL868585 CZ467633 CZ487054 CZ488088 CZ488089 G01458 X55199 X78577 Entrez Gene - A searchable database of RefSeq genes. • 45959 UniProtKB/Swiss-Prot • P23696
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Metallophosphoesterase domain (IPR004843) Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase (IPR006186)
Linkouts
	BioGRID - A database of protein and genetic interactions • 70018 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0004177 DroID - A comprehensive database of gene and protein interactions. • FBgn0004177 DRSC - Results from RNAi screens. • FBgn0004177 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004177 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7109-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0004177 FlyReactome - A curated knowledgebase of Drosophila melanogaster pathways • 97568 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 45959 InParanoid A subset of ortholog calls from InParanoid. • AAEL013068-PA Aedes aegypti (mosquito) AGAP010172-PA Anopheles gambiae (mosquito) XP_623105.1 Apis mellifera (honey bee) NP_001119644.1 Acyrthosiphon pisum (pea aphid) At1g10430.1 Arabidopsis thaliana (wall cress) 18460 Batrachochytrium dendrobatidis (chytrid fungus) 123893 Branchiostoma floridae (lancelet) BGIBMGA007460-PA Bombyx mori (silk worm) ENSBTAP00000012182 Bos taurus (bovine) CAL0000149 Candida albicans (a form of yeast) CN19062 Caenorhabditis brenneri (small nematode) CBP01534 Caenorhabditis briggsae (nematode) CE10074 Caenorhabditis elegans (worm) ENSCAFP00000009667 Canis familiaris (dog) CAGL0I03938g Candida glabrata (haploid yeast) Chro.70100 Cryptosporidium hominis (obligate parasite) JA08511 Caenorhabditis japonica (nematode) CML332C Cyanidioschyzon merolae (red alga) cn05366 Cryptococcus neoformans (yeast-like fungus) cgd7_810 Cryptosporidium parvum (protozoan parasite) CPIJ013232 Culex pipens (mosquito) ENSCPOP00000004648 Cavia porcellus (guinea pig) 193562 Chlamidomonas reinhardtii (green alga) RP42020 Caenorhabditis remanei (nematode) ENSCSAVP00000001589 Ciona savignyi (sedentary tunicate) 227677 Capitella spl (polychaete worm) DDB0191299 Dictyostelium discoideum (amoeba) DEHA2D15290g Debaryomyces Hansenii (yeast) ENSDARP00000062145 Danio rerio (zebra fish) ENSECAP00000009288 Equus caballus (horse) XP_656214 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000027616 Gymnopilus aculeatus (mushroom) ENSGALP00000010423 Gallus gallus (chicken) GL50803_5010 Giardia lamblia (flagellated protozoan) 98479 Hypsipyla robusta (cedar shoot borer) ENSP00000384493 Homo sapiens (human) ISCW014549-PA Ixodes scapularis (deer tick) KLLA0F05357g Kluyveromyces lactis (yeast) 184125 Lottia gigantea (owl limpet) LmjF25.1320 Leishmania major (virus) 20632 Monocosta brevicollis (choanoflagellate) ENSMODP00000017725 Monodelphis domestica (gray opossum) ENSMODP00000023713 Monodelphis domestica (gray opossum) ENSMMUP00000027404 Macaca mulatta (rhesus monkey) ENSMUSP00000009774 Mus musculus (house mouse) 195622 Nematostella vectensis (starlet anemone) ENSOANP00000021328 Ornithorynchus anatinus (platypus) ENSORLP00000001162 Oryzias latipes (japanese killifish) LOC_Os06g37660.1 Oryza sativa (asian rice) 18276 Ostreococcus tauri (green alga) PHUM005300-PA Pediculus humanus (human body louse) PP20779 Pristionchus pacificus (nematode) 226377 Physcomitrella patens (moss) ENSPPYP00000020727 Pongo pygmaeus (orangutan) 71251 Phytophthora ramorum (sudden oak death pathogen) 109378 Phytophthora sojae (root rot pathogen) 833487 Populus trichocarpa (black cottonwood) ENSPTRP00000034477 Pan troglodytes (chimpanzee) ENSRNOP00000020663 Rattus norvegicus (norway rat) 4869567 Sorghum bicolor (sorghum) YDL188C Saccharomyces cerevisiae (budding yeast) Smp_165490 Schistosoma mansoni (trematode parasite) SPBC16H5.07c Schizosaccharomyces pombe (fission yeast) XP_001178176.1 Strongylocentrotus purpuratus (purple sea urchin) 63380 Trichoplax adhaerens (metazoa) TA15515 Theileria annulata (apicomplexan parasite) XP_973546.1 Tribolium castaneum (red flour beetle) Tc00.1047053509453.50 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053511881.20 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000019184 Tetraodon nigroviridis (green spotted pufferfish) TP02_0853 Theileria parva (parasitic protozoan) 1585 Thalassiosira pseudonana (marine diatom) ENSTRUP00000019973 Takifugu rubripes (pufferfish Takifugu) 3732.m00070 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000035093 Xenopus tropicalis (frog) YALI0F14069g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 45959 modMine - Data generated by the modENCODE project. • FBgn0004177 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB17228 NV13733 LH13436 ISCW014549 FBgn0232234 FBgn0225683 FBgn0204408 FBgn0194871 FBgn0171522 JGI_V11_68048 FBgn0247114 FBgn0156247 FBgn0137714 FBgn0117689 FBgn0102809 FBgn0098831 CPIJ013232 BGIBMGA007460 ACYPI000060 GB14863 AGAP010172 AAEL013068 PHUM269020 GLEAN_05366
Synonyms & Secondary IDs ( 29 )
Reported As
Symbol Synonym	5559 (Harvie et al., 1998) CG7109 (Wang et al., 2009, Coulier et al., 2000, Morrison et al., 2000, Nybakken et al., 2005, Dobbelaere et al., 2008, Jia et al., 2009, Perkins et al., 2009, Cammarato et al., 2011) DmPp2A-28D (Cohen, 2005) dPP2A (Berry and Gehring, 1999, Merrow, 2006) ER2-6 (Chang et al., 1994, ) l(2)02496   l(2)s5286   mts (Casso et al., 2008, Wang et al., 2009, Casso et al., 2007, Christensen and Cook, 2006.12.5, Christensen and Cook, 2006.8.29, Ramel, 2007, Christensen and Cook, 2006.8.29, Christensen and Cook, 2006.8.29, Wang et al., 2008, Stroschein-Stevenson et al., 2006, Stuart et al., 2007, Chen et al., 2007, Kadrmas et al., 2007, Nybakken et al., 2005, Kunttas-Tatli et al., 2009, Casso et al., 2008, Kunttas et al., 2008, Viquez et al., 2006, Dobbelaere et al., 2008, Stofanko et al., 2008, Jia et al., 2009, Moazzen et al., 2009, Zhang et al., 2009, Ogawa et al., 2009, Viquez et al., 2009, Chen et al., 2008, Salzer et al., 2010, Ribeiro et al., 2010, Maher et al., 2011, Kotadia et al., 2008, Chang et al., 2010, Wang et al., 2011) Mts (Nam et al., 2007, Chabu and Doe, 2009, Viquez et al., 2006, Bandyopadhyay et al., 2006) MTS/PP2A (Morrison et al., 2000, Friedman and Perrimon, 2006) PP2 (Biswas et al., 2006, Cohen, 1994.4.1) PP2a (Hardin, 2005, Jenny et al., 2008) PP2A (Kyriacou and Odell, 2004, Lu et al., 2003, Bennett et al., 2003, Bennett et al., 1999, Millward et al., 1999, Helps et al., 1998, Hermon et al., 1998, Karim et al., 1997, Snaith et al., 1996, Karim et al., 1996, Chang et al., 1994, Chang et al., 1994, Orgad et al., 1990, Dombradi et al., 1990, Kunttas et al., 2007, Nam et al., 2007, Fang et al., 2007, Bose et al., 2008, Nogueira et al., 2008, Su et al., 2008, Choi et al., 2007, Serio et al., 2010) Pp2A (Therrien et al., 1995, ) PP2a 28D (Lee et al., 2001) PP2A 28D (Cohen, 1997, Chen et al., 1992) Pp2A-28D (Guo et al., 1996, ) PP2AC (Janssens and Goris, 2001) PP2AC (Kotadia et al., 2008) PP2A-C (Wang et al., 2009, Matsubayashi et al., 2004) PP2Ac (Cygnar, 2005, Yanagawa et al., 2000) PP2A C (Li et al., 2002)
Name Synonym	catalytic subunit C of type 2A protein phosphatase (Shiomi et al., 1994) microtubule star (Casso et al., 2008, Kadrmas et al., 2007, Kunttas-Tatli et al., 2009, Casso et al., 2008, Stofanko et al., 2008, Moazzen et al., 2009, Viquez et al., 2006, Ogawa et al., 2009, Wang et al., 2008, Viquez et al., 2009, Salzer et al., 2010, Ribeiro et al., 2010, Kotadia et al., 2008, Cammarato et al., 2011, Wang et al., 2011) Microtubule star (Chabu and Doe, 2009, Nie et al., 2009, Wang et al., 2004) phosphatase 2A catalytic subunit (Orgad, 1993.2.24) PP2A catalytic subunit (Jia et al., 2009, Nie et al., 2009, Viquez et al., 2009) protein phosphatase 2A (Bose et al., 2008, Choi et al., 2007) Protein phosphatase 2A at 28D
Secondary FlyBase IDs
	FBgn0010514 FBgn0010703 FBgn0031953
References ( 131 )
Generate a list of	All references relating to this gene ( 131 )
List References by type	Research paper  ( 71 ) Supplementary material  ( 7 ) Review  ( 10 ) Personal communication to FlyBase  ( 14 ) Abstract  ( 16 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 2 ) Letter  ( 1 ) Computer file  ( 4 ) Protein sequence record  ( 1 ) Curated genome annotation  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers ( 11 )
	Booker et al., 2011, BMC Genomics 12: 50 False negative rates in Drosophila cell-based RNAi screens: a case study. [FBrf0212969] Horn et al., 2011, Nat. Methods 8(4): 341--346 Mapping of signaling networks through synthetic genetic interaction analysis by RNAi. [FBrf0213352] Maher et al., 2011, Hum. Mol. Genet. 20(2): 261--270 ERK activation by the polyphenols fisetin and resveratrol provides neuroprotection in multiple models of Huntington's disease. [FBrf0212618] Rangone et al., 2011, PLoS Genet. 7(8): e1002225 Suppression of Scant Identifies Endos as a Substrate of Greatwall Kinase and a Negative Regulator of Protein Phosphatase 2A in Mitosis. [FBrf0214749] Su et al., 2011, Sci. Signal. 4(180): ra43 Sequential phosphorylation of smoothened transduces graded hedgehog signaling. [FBrf0216577] Wang et al., 2011, PLoS Genet. 7(8): e1002227 PP2A-Twins Is Antagonized by Greatwall and Collaborates with Polo for Cell Cycle Progression and Centrosome Attachment to Nuclei in Drosophila Embryos. [FBrf0214683] Chang et al., 2010, Dev. Cell 19(5): 778--785 Interplay between the Transcription Factor Zif and aPKC Regulates Neuroblast Polarity and Self-Renewal. [FBrf0212286] Müller et al., 2010, EMBO J. 29(19): 3344--3357 Proteomic and functional analysis of the mitotic Drosophila centrosome. [FBrf0212030] Ribeiro et al., 2010, Mol. Cell 39(4): 521--534 Combined Functional Genomic and Proteomic Approaches Identify a PP2A Complex as a Negative Regulator of Hippo Signaling. [FBrf0211636] Salzer et al., 2010, Genetics 184(1): 185--197 The retinal determination gene eyes absent is regulated by the EGF receptor pathway throughout development in Drosophila. [FBrf0209690] Serio et al., 2010, Cell Host Microbe 7(5): 388--398 Defining a Core Set of Actin Cytoskeletal Proteins Critical for Actin-Based Motility of Rickettsia. [FBrf0210774] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...