A Database of Drosophila Genes & Genomes

FB2012_01, released January 20th, 2012
 

Gene Dmel\mts

General Information
SymbolDmel\mtsSpeciesD. melanogaster
Namemicrotubule starAnnotation symbolCG7109
Feature typeprotein_coding_geneFlyBase IDFBgn0004177
Gene Model StatusCurrent Stock availability 15 publicly available
Also Known AsPP2a, PP2a 28D, PP2A-C, PP2, PP2Ac, MTS/PP2A, dPP2A
Genomic Location
Chromosome (arm)2LRecombination map
Cytogenetic map28D1-28D2Sequence location2L:7,827,743..7,832,745 [+]

Genomic Maps

GBrowse View Help
modENCODE GBrowse
detailed view
hide Summary Information
Automatically generated summary

See sections below for more information
The gene microtubule star is referred to in FlyBase by the symbol Dmel\mts (CG7109, FBgn0004177). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: phosphatase regulator activity; protein serine/threonine phosphatase activity. There is experimental evidence for 21 unique biological process terms, many of which group under: cellular component organization or biogenesis; cell cycle; biological regulation; cell cycle process; anatomical structure development; organelle organization; chromosome segregation; response to light stimulus; macromolecule modification; establishment or maintenance of cell polarity; multicellular organismal reproductive process. 29 alleles are reported. The phenotypes of these alleles are annotated with: eye; embryonic/larval brain; wing hair; embryonic/larval neuroblast. It has one annotated transcript and one annotated polypeptide. Protein features are: Metallophosphoesterase domain; Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of high expression. Peak expression observed within 00-18 hour embryonic stages, during late larval stages, during early pupal stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, adult crop, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval trachea, adult female reproductive system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult midgut, larval/adult salivary gland, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1640841_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of mts. Gene sequence location is 2L:7827743..7832745.

hide Recent Updates
Description
What does this section display?
This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).
What does this section not display?
This section does not currently display links that were removed or gene model changes.
Update Feed
Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
References
FB2012_01
References
Controlled Vocabulary Terms
Sequence features
All updates Click here to see a list of all updates to this record from FB2010_08 and on.
hide Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
28D1-28D2  
Limits computationally determined from genome sequence between P{EP}EP2178 and P{PZ}mts02496  
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
28D1-28D2  
(determined by in situ hybridisation)  
28D-28D  
(determined by in situ hybridisation)  
28D1-28D2  
(determined by in situ hybridisation)  
28D2-28D4  
(determined by in situ hybridisation)  
28D2-28D4  
(determined by in situ hybridisation)  
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
hide Gene Model & Products
Please see the GBrowse view of Dmel\mts for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
detailed view FBtr0079565 FBtr0079525 FBpp0079187 FBpp0079148 FBti0048767 FBti0065567 FBti0143817 FBti0024834 FBti0005216_1 FBti0124640_2 FBti0124640_1 FBti0005216_2 FBti0026314 FBti0113495 FBti0112420 FBti0111045 FBti0011103 FBti0108613 FBti0108810 FBti0057734 FBti0109931 FBti0043924 FBti0052388 FBti0124641_2 FBti0067755 FBti0143650 FBti0124641_1 FBti0033819 FBti0058015
Comments on Gene Model
hide Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Associated CDS (aa)
FBtr0079525
  2178
  309
Additional Transcript Data & Comments
Reported size (kB)
2.5, 1.6 (northern blot)
2.3, 1.5 (northern blot)
Comments
External Data
Crossreferences
hide Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
mts-PA  
FBpp0079148  
35.5  
309  
4.97  
Additional Polypeptide Data & Comments
Reported size (kDa)
309 (aa); 35.42 (kD predicted)
Comments
External Data
Linkouts
Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
hide Sequences Consistent with the Gene Model
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
 
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
hide Mapped Features
Mapped Features have been reorganized, please see this article for details.
Additional mapped features and mutations can be found on GBrowse or related reports.
Type
Symbol & Location
Additional Notes
References
hide External Data
Linkouts
Crossreferences
hide Expression Data
hideTranscript Expression
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
radioisotope in situ
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
The 2.3kb mts transcript is strongly expressed in early embryos and is reduced ~20fold in late embryos and larvae.
The 1.5kb mts transcript is strongly expressed in eary embryos and decreases about 60% in late embryos and larvae. It is also detected in adults.
The 2.3 and 1.5 kb mts transcripts are expressed throughout development. Expression is especially high in 0-4 hr embryos.
Expression was observed in cryostat sections at several different stages of development. In adult females, basal levels of Pp2A-29B transcripts are detected in all tissues. High levels of expression are observed in the ovary in the nurse cells and oocytes. Slightly elevated levels are observed in the brain and the gut. In early embryos, transcripts are evenly distributed at high levels. In later embryos, the levels decline but slightly higher levels are seen in the developing CNS than in surrounding tissue. In third instar larvae, transcripts are enriched in the supraesophageal ganglion but are at very low levels in the neuropil. Elevated levels are observed in imaginal discs and salivary glands. In early embryos, in situ hybridization reveals uniform expression. Enrichment is observed in neuroblasts at germ band extension and in the ventral nerve cord and supraesophageal ganglion at later embryonic stages. In addition elevated levels are observed in the gonads.
Marker for
Subcellular Localization
CV Term
Notes
hidePolypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Pp2A-29B and mts proteins show the same cytoplasmic localization in embryos and imaginal discs as the tws protein. In syncytial blastoderm embryos the protein is found in the cytoplasmic region surrounding the cortical layer of nuclei. The protein is cytoplasmic in pole cells. In cycle 14 embryos, the protein is located throughout the cytoplasm of interphase cells, and throughout the whole cell as it progresses through mitosis. In dividing third larval instar brain neuroblasts, the protein is detected in the cytoplasm of interphase and mitotic cells.
Marker for
Subcellular Localization
CV Term
Notes
hide High-Throughput Expression Data
or
Untitled Document detailed view Rack1-RA mts-RA
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.

modENCODE Temporal Expression Data for FBgn0004177


   Styles
Linear
Logarithmic
Heatmap
   Scales
max expr for FBgn0004177
Very low expression bin max
Moderate expression bin max
High expression bin max
Extremely high expression bin max

Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of high expression. Peak expression observed within 00-18 hour embryonic stages, during late larval stages, during early pupal stages, in adult female stages.
[download data (TSV)]

Guide to modENCODE expression level colors
 
No expression (0 - 0)
 
Extremely low expression (1 - 10)
 
Very low expression (11 - 100)
 
Low expression (101 - 400)
 
Moderate expression (401 - 1400)
 
Moderately high expression (1401 - 4000)
 
High expression (4001 - 10000)
 
Very high expression (10001 - 100000)
 
Extremely high expression (100001 - 2000000)

Linear, scaled to maximum FBgn0004177 expression level
Developmental Stage   Expression Level
embryo 00-02hr
 
 20771
embryo 02-04hr
 
 28878
embryo 04-06hr
 
 23806
embryo 06-08hr
 
 22243
embryo 08-10hr
 
 20872
embryo 10-12hr
 
 19177
embryo 12-14hr
 
 13549
embryo 14-16hr
 
 10438
embryo 16-18hr
 
 10269
embryo 18-20hr
 
 9468
embryo 20-22hr
 
 9456
embryo 22-24hr
 
 9923
larva L1
 
 8322
larva L2
 
 8263
larva L3 12hr old
 
 7722
larva L3 puffstage 1-2
 
 8210
larva L3 puffstage 3-6
 
 10508
larva L3 puffstage 7-9
 
 13860
white prepupae new
 
 12998
white prepupae 12hr
 
 11739
white prepupae 24hr
 
 13039
pupae 2d postWPP
 
 9898
pupae 3d postWPP
 
 7533
pupae 4d postWPP
 
 9450
adult male 01day
 
 5996
adult male 05day
 
 5766
adult male 30day
 
 5186
adult female 01day
 
 9023
adult female 05day
 
 12896
adult female 30day
 
 12789
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
Linear, scaled to Very low expression
Developmental Stage   Expression Level
embryo 00-02hr
 (20771)
embryo 02-04hr
 (28878)
embryo 04-06hr
 (23806)
embryo 06-08hr
 (22243)
embryo 08-10hr
 (20872)
embryo 10-12hr
 (19177)
embryo 12-14hr
 (13549)
embryo 14-16hr
 (10438)
embryo 16-18hr
 (10269)
embryo 18-20hr
 (9468)
embryo 20-22hr
 (9456)
embryo 22-24hr
 (9923)
larva L1
 (8322)
larva L2
 (8263)
larva L3 12hr old
 (7722)
larva L3 puffstage 1-2
 (8210)
larva L3 puffstage 3-6
 (10508)
larva L3 puffstage 7-9
 (13860)
white prepupae new
 (12998)
white prepupae 12hr
 (11739)
white prepupae 24hr
 (13039)
pupae 2d postWPP
 (9898)
pupae 3d postWPP
 (7533)
pupae 4d postWPP
 (9450)
adult male 01day
 (5996)
adult male 05day
 (5766)
adult male 30day
 (5186)
adult female 01day
 (9023)
adult female 05day
 (12896)
adult female 30day
 (12789)
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
Linear, scaled to Moderate expression
Developmental Stage   Expression Level
embryo 00-02hr
 (20771)
embryo 02-04hr
 (28878)
embryo 04-06hr
 (23806)
embryo 06-08hr
 (22243)
embryo 08-10hr
 (20872)
embryo 10-12hr
 (19177)
embryo 12-14hr
 (13549)
embryo 14-16hr
 (10438)
embryo 16-18hr
 (10269)
embryo 18-20hr
 (9468)
embryo 20-22hr
 (9456)
embryo 22-24hr
 (9923)
larva L1
 (8322)
larva L2
 (8263)
larva L3 12hr old
 (7722)
larva L3 puffstage 1-2
 (8210)
larva L3 puffstage 3-6
 (10508)
larva L3 puffstage 7-9
 (13860)
white prepupae new
 (12998)
white prepupae 12hr
 (11739)
white prepupae 24hr
 (13039)
pupae 2d postWPP
 (9898)
pupae 3d postWPP
 (7533)
pupae 4d postWPP
 (9450)
adult male 01day
 (5996)
adult male 05day
 (5766)
adult male 30day
 (5186)
adult female 01day
 (9023)
adult female 05day
 (12896)
adult female 30day
 (12789)
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
Linear, scaled to High expression
Developmental Stage   Expression Level
embryo 00-02hr
 (20771)
embryo 02-04hr
 (28878)
embryo 04-06hr
 (23806)
embryo 06-08hr
 (22243)
embryo 08-10hr
 (20872)
embryo 10-12hr
 (19177)
embryo 12-14hr
 (13549)
embryo 14-16hr
 10438
embryo 16-18hr
 10269
embryo 18-20hr
 
 9468
embryo 20-22hr
 
 9456
embryo 22-24hr
 
 9923
larva L1
 
 8322
larva L2
 
 8263
larva L3 12hr old
 
 7722
larva L3 puffstage 1-2
 
 8210
larva L3 puffstage 3-6
 10508
larva L3 puffstage 7-9
 (13860)
white prepupae new
 (12998)
white prepupae 12hr
 (11739)
white prepupae 24hr
 (13039)
pupae 2d postWPP
 
 9898
pupae 3d postWPP
 
 7533
pupae 4d postWPP
 
 9450
adult male 01day
 
 5996
adult male 05day
 
 5766
adult male 30day
 
 5186
adult female 01day
 
 9023
adult female 05day
 (12896)
adult female 30day
 (12789)
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
Linear, scaled to Extremely high expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 20771
embryo 02-04hr
 
 28878
embryo 04-06hr
 
 23806
embryo 06-08hr
 
 22243
embryo 08-10hr
 
 20872
embryo 10-12hr
 
 19177
embryo 12-14hr
 
 13549
embryo 14-16hr
 
 10438
embryo 16-18hr
 
 10269
embryo 18-20hr
 
 9468
embryo 20-22hr
 
 9456
embryo 22-24hr
 
 9923
larva L1
 
 8322
larva L2
 
 8263
larva L3 12hr old
 
 7722
larva L3 puffstage 1-2
 
 8210
larva L3 puffstage 3-6
 
 10508
larva L3 puffstage 7-9
 
 13860
white prepupae new
 
 12998
white prepupae 12hr
 
 11739
white prepupae 24hr
 
 13039
pupae 2d postWPP
 
 9898
pupae 3d postWPP
 
 7533
pupae 4d postWPP
 
 9450
adult male 01day
 
 5996
adult male 05day
 
 5766
adult male 30day
 
 5186
adult female 01day
 
 9023
adult female 05day
 
 12896
adult female 30day
 
 12789
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
 Extremely high 
log, scaled to maximum FBgn0004177 expression level
Developmental Stage   Expression Level
embryo 00-02hr
 
 20771
embryo 02-04hr
 
 28878
embryo 04-06hr
 
 23806
embryo 06-08hr
 
 22243
embryo 08-10hr
 
 20872
embryo 10-12hr
 
 19177
embryo 12-14hr
 
 13549
embryo 14-16hr
 
 10438
embryo 16-18hr
 
 10269
embryo 18-20hr
 
 9468
embryo 20-22hr
 
 9456
embryo 22-24hr
 
 9923
larva L1
 
 8322
larva L2
 
 8263
larva L3 12hr old
 
 7722
larva L3 puffstage 1-2
 
 8210
larva L3 puffstage 3-6
 
 10508
larva L3 puffstage 7-9
 
 13860
white prepupae new
 
 12998
white prepupae 12hr
 
 11739
white prepupae 24hr
 
 13039
pupae 2d postWPP
 
 9898
pupae 3d postWPP
 
 7533
pupae 4d postWPP
 
 9450
adult male 01day
 
 5996
adult male 05day
 
 5766
adult male 30day
 
 5186
adult female 01day
 
 9023
adult female 05day
 
 12896
adult female 30day
 
 12789
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
log, scaled to Very low expression
Developmental Stage   Expression Level
embryo 00-02hr
 (20771)
embryo 02-04hr
 (28878)
embryo 04-06hr
 (23806)
embryo 06-08hr
 (22243)
embryo 08-10hr
 (20872)
embryo 10-12hr
 (19177)
embryo 12-14hr
 (13549)
embryo 14-16hr
 (10438)
embryo 16-18hr
 (10269)
embryo 18-20hr
 (9468)
embryo 20-22hr
 (9456)
embryo 22-24hr
 (9923)
larva L1
 (8322)
larva L2
 (8263)
larva L3 12hr old
 (7722)
larva L3 puffstage 1-2
 (8210)
larva L3 puffstage 3-6
 (10508)
larva L3 puffstage 7-9
 (13860)
white prepupae new
 (12998)
white prepupae 12hr
 (11739)
white prepupae 24hr
 (13039)
pupae 2d postWPP
 (9898)
pupae 3d postWPP
 (7533)
pupae 4d postWPP
 (9450)
adult male 01day
 (5996)
adult male 05day
 (5766)
adult male 30day
 (5186)
adult female 01day
 (9023)
adult female 05day
 (12896)
adult female 30day
 (12789)
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
log, scaled to Moderate expression
Developmental Stage   Expression Level
embryo 00-02hr
 (20771)
embryo 02-04hr
 (28878)
embryo 04-06hr
 (23806)
embryo 06-08hr
 (22243)
embryo 08-10hr
 (20872)
embryo 10-12hr
 (19177)
embryo 12-14hr
 (13549)
embryo 14-16hr
 (10438)
embryo 16-18hr
 (10269)
embryo 18-20hr
 (9468)
embryo 20-22hr
 (9456)
embryo 22-24hr
 (9923)
larva L1
 (8322)
larva L2
 (8263)
larva L3 12hr old
 (7722)
larva L3 puffstage 1-2
 (8210)
larva L3 puffstage 3-6
 (10508)
larva L3 puffstage 7-9
 (13860)
white prepupae new
 (12998)
white prepupae 12hr
 (11739)
white prepupae 24hr
 (13039)
pupae 2d postWPP
 (9898)
pupae 3d postWPP
 (7533)
pupae 4d postWPP
 (9450)
adult male 01day
 (5996)
adult male 05day
 (5766)
adult male 30day
 (5186)
adult female 01day
 (9023)
adult female 05day
 (12896)
adult female 30day
 (12789)
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
log, scaled to High expression
Developmental Stage   Expression Level
embryo 00-02hr
 (20771)
embryo 02-04hr
 (28878)
embryo 04-06hr
 (23806)
embryo 06-08hr
 (22243)
embryo 08-10hr
 (20872)
embryo 10-12hr
 19177
embryo 12-14hr
 13549
embryo 14-16hr
 10438
embryo 16-18hr
 10269
embryo 18-20hr
 
 9468
embryo 20-22hr
 
 9456
embryo 22-24hr
 
 9923
larva L1
 
 8322
larva L2
 
 8263
larva L3 12hr old
 
 7722
larva L3 puffstage 1-2
 
 8210
larva L3 puffstage 3-6
 10508
larva L3 puffstage 7-9
 13860
white prepupae new
 12998
white prepupae 12hr
 11739
white prepupae 24hr
 13039
pupae 2d postWPP
 
 9898
pupae 3d postWPP
 
 7533
pupae 4d postWPP
 
 9450
adult male 01day
 
 5996
adult male 05day
 
 5766
adult male 30day
 
 5186
adult female 01day
 
 9023
adult female 05day
 12896
adult female 30day
 12789
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
log, scaled to Extremely high expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 20771
embryo 02-04hr
 
 28878
embryo 04-06hr
 
 23806
embryo 06-08hr
 
 22243
embryo 08-10hr
 
 20872
embryo 10-12hr
 
 19177
embryo 12-14hr
 
 13549
embryo 14-16hr
 
 10438
embryo 16-18hr
 
 10269
embryo 18-20hr
 
 9468
embryo 20-22hr
 
 9456
embryo 22-24hr
 
 9923
larva L1
 
 8322
larva L2
 
 8263
larva L3 12hr old
 
 7722
larva L3 puffstage 1-2
 
 8210
larva L3 puffstage 3-6
 
 10508
larva L3 puffstage 7-9
 
 13860
white prepupae new
 
 12998
white prepupae 12hr
 
 11739
white prepupae 24hr
 
 13039
pupae 2d postWPP
 
 9898
pupae 3d postWPP
 
 7533
pupae 4d postWPP
 
 9450
adult male 01day
 
 5996
adult male 05day
 
 5766
adult male 30day
 
 5186
adult female 01day
 
 9023
adult female 05day
 
 12896
adult female 30day
 
 12789
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
 Extremely high 
Heatmap
Developmental Stage   Expression Level
embryo 00-02hr
 
 
embryo 02-04hr
 
 
embryo 04-06hr
 
 
embryo 06-08hr
 
 
embryo 08-10hr
 
 
embryo 10-12hr
 
 
embryo 12-14hr
 
 
embryo 14-16hr
 
 
embryo 16-18hr
 
 
embryo 18-20hr
 
 
embryo 20-22hr
 
 
embryo 22-24hr
 
 
larva L1
 
 
larva L2
 
 
larva L3 12hr old
 
 
larva L3 puffstage 1-2
 
 
larva L3 puffstage 3-6
 
 
larva L3 puffstage 7-9
 
 
white prepupae new
 
 
white prepupae 12hr
 
 
white prepupae 24hr
 
 
pupae 2d postWPP
 
 
pupae 3d postWPP
 
 
pupae 4d postWPP
 
 
adult male 01day
 
 
adult male 05day
 
 
adult male 30day
 
 
adult female 01day
 
 
adult female 05day
 
 
adult female 30day
 
 

FlyAtlas Anatomical Expression Data for FBgn0004177


   Styles
Linear
Logarithmic
Heatmap
Back-to-back
   Scales
max expr for FBgn0004177
Moderate expression bin max
High level expression bin max
Very high expression bin max

Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, adult crop, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval trachea, adult female reproductive system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult midgut, larval/adult salivary gland, adult male reproductive system, larval/adult carcass.
[download data (TSV)]

Guide to FlyAtlas expression level colors
 
No expression (0 - 9.999)
 
Low expression (10 - 99.999)
 
Moderate expression (100 - 499.999)
 
High level expression (500 - 999.999)
 
Very high expression (1000 - 25000)

Linear, scaled to maximum FBgn0004177 expression level
Tissue   Expression Level
Larval Central Nervous System
 
 943.2
Larval Midgut
 
 430.6
Larval Hindgut
 
 677.2
Larval Malpighian Tubules
 
 842.6
Larval Fat Body
 
 795.1
Larval Salivary Gland
 
 436.8
Larval Trachea
 
 700.125
Larval Carcass
 
 326.475
Adult Head
 
 488.1
Adult Eye
 
 846.075
Adult Brain
 
 921.9
Adult Thoracic-Abdominal Ganglion
 
 809
Adult Crop
 
 672.7
Adult Midgut
 
 342.1
Adult Hindgut
 
 570.1
Adult Malpighian Tubules
 
 749.1
Adult Fat Body
 
 528.8
Adult Salivary Gland
 
 406.9
Adult Heart
 
 753.775
Adult VirginFemale Spermatheca
 
 815.7
Adult InseminatedFemale Spermatheca
 
 701.1
Adult Ovary
 
 664.9
Adult Testis
 
 170.9
Adult Male Accessory Gland
 
 407.1
Adult Carcass
 
 443.9
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
Linear, scaled to Moderate expression
Tissue   Expression Level
Larval Central Nervous System
 (943.2)
Larval Midgut
 
 430.6
Larval Hindgut
 (677.2)
Larval Malpighian Tubules
 (842.6)
Larval Fat Body
 (795.1)
Larval Salivary Gland
 
 436.8
Larval Trachea
 (700.125)
Larval Carcass
 
 326.475
Adult Head
 
 488.1
Adult Eye
 (846.075)
Adult Brain
 (921.9)
Adult Thoracic-Abdominal Ganglion
 (809)
Adult Crop
 (672.7)
Adult Midgut
 
 342.1
Adult Hindgut
 (570.1)
Adult Malpighian Tubules
 (749.1)
Adult Fat Body
 528.8
Adult Salivary Gland
 
 406.9
Adult Heart
 (753.775)
Adult VirginFemale Spermatheca
 (815.7)
Adult InseminatedFemale Spermatheca
 (701.1)
Adult Ovary
 (664.9)
Adult Testis
 
 170.9
Adult Male Accessory Gland
 
 407.1
Adult Carcass
 
 443.9
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
Linear, scaled to High level expression
Tissue   Expression Level
Larval Central Nervous System
 
 943.2
Larval Midgut
 
 430.6
Larval Hindgut
 
 677.2
Larval Malpighian Tubules
 
 842.6
Larval Fat Body
 
 795.1
Larval Salivary Gland
 
 436.8
Larval Trachea
 
 700.125
Larval Carcass
 
 326.475
Adult Head
 
 488.1
Adult Eye
 
 846.075
Adult Brain
 
 921.9
Adult Thoracic-Abdominal Ganglion
 
 809
Adult Crop
 
 672.7
Adult Midgut
 
 342.1
Adult Hindgut
 
 570.1
Adult Malpighian Tubules
 
 749.1
Adult Fat Body
 
 528.8
Adult Salivary Gland
 
 406.9
Adult Heart
 
 753.775
Adult VirginFemale Spermatheca
 
 815.7
Adult InseminatedFemale Spermatheca
 
 701.1
Adult Ovary
 
 664.9
Adult Testis
 
 170.9
Adult Male Accessory Gland
 
 407.1
Adult Carcass
 
 443.9
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
Linear, scaled to Very high expression
Tissue   Expression Level
Larval Central Nervous System
 
 943.2
Larval Midgut
 
 430.6
Larval Hindgut
 
 677.2
Larval Malpighian Tubules
 
 842.6
Larval Fat Body
 
 795.1
Larval Salivary Gland
 
 436.8
Larval Trachea
 
 700.125
Larval Carcass
 
 326.475
Adult Head
 
 488.1
Adult Eye
 
 846.075
Adult Brain
 
 921.9
Adult Thoracic-Abdominal Ganglion
 
 809
Adult Crop
 
 672.7
Adult Midgut
 
 342.1
Adult Hindgut
 
 570.1
Adult Malpighian Tubules
 
 749.1
Adult Fat Body
 
 528.8
Adult Salivary Gland
 
 406.9
Adult Heart
 
 753.775
Adult VirginFemale Spermatheca
 
 815.7
Adult InseminatedFemale Spermatheca
 
 701.1
Adult Ovary
 
 664.9
Adult Testis
 
 170.9
Adult Male Accessory Gland
 
 407.1
Adult Carcass
 
 443.9
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
log, scaled to maximum FBgn0004177 expression level
Tissue   Expression Level
Larval Central Nervous System
 
 943.2
Larval Midgut
 
 430.6
Larval Hindgut
 
 677.2
Larval Malpighian Tubules
 
 842.6
Larval Fat Body
 
 795.1
Larval Salivary Gland
 
 436.8
Larval Trachea
 
 700.125
Larval Carcass
 
 326.475
Adult Head
 
 488.1
Adult Eye
 
 846.075
Adult Brain
 
 921.9
Adult Thoracic-Abdominal Ganglion
 
 809
Adult Crop
 
 672.7
Adult Midgut
 
 342.1
Adult Hindgut
 
 570.1
Adult Malpighian Tubules
 
 749.1
Adult Fat Body
 
 528.8
Adult Salivary Gland
 
 406.9
Adult Heart
 
 753.775
Adult VirginFemale Spermatheca
 
 815.7
Adult InseminatedFemale Spermatheca
 
 701.1
Adult Ovary
 
 664.9
Adult Testis
 
 170.9
Adult Male Accessory Gland
 
 407.1
Adult Carcass
 
 443.9
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
log, scaled to Moderate expression
Tissue   Expression Level
Larval Central Nervous System
 (943.2)
Larval Midgut
 
 430.6
Larval Hindgut
 677.2
Larval Malpighian Tubules
 (842.6)
Larval Fat Body
 795.1
Larval Salivary Gland
 
 436.8
Larval Trachea
 700.125
Larval Carcass
 
 326.475
Adult Head
 
 488.1
Adult Eye
 (846.075)
Adult Brain
 (921.9)
Adult Thoracic-Abdominal Ganglion
 809
Adult Crop
 672.7
Adult Midgut
 
 342.1
Adult Hindgut
 570.1
Adult Malpighian Tubules
 749.1
Adult Fat Body
 528.8
Adult Salivary Gland
 
 406.9
Adult Heart
 753.775
Adult VirginFemale Spermatheca
 (815.7)
Adult InseminatedFemale Spermatheca
 701.1
Adult Ovary
 664.9
Adult Testis
 
 170.9
Adult Male Accessory Gland
 
 407.1
Adult Carcass
 
 443.9
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
log, scaled to High level expression
Tissue   Expression Level
Larval Central Nervous System
 
 943.2
Larval Midgut
 
 430.6
Larval Hindgut
 
 677.2
Larval Malpighian Tubules
 
 842.6
Larval Fat Body
 
 795.1
Larval Salivary Gland
 
 436.8
Larval Trachea
 
 700.125
Larval Carcass
 
 326.475
Adult Head
 
 488.1
Adult Eye
 
 846.075
Adult Brain
 
 921.9
Adult Thoracic-Abdominal Ganglion
 
 809
Adult Crop
 
 672.7
Adult Midgut
 
 342.1
Adult Hindgut
 
 570.1
Adult Malpighian Tubules
 
 749.1
Adult Fat Body
 
 528.8
Adult Salivary Gland
 
 406.9
Adult Heart
 
 753.775
Adult VirginFemale Spermatheca
 
 815.7
Adult InseminatedFemale Spermatheca
 
 701.1
Adult Ovary
 
 664.9
Adult Testis
 
 170.9
Adult Male Accessory Gland
 
 407.1
Adult Carcass
 
 443.9
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
log, scaled to Very high expression
Tissue   Expression Level
Larval Central Nervous System
 
 943.2
Larval Midgut
 
 430.6
Larval Hindgut
 
 677.2
Larval Malpighian Tubules
 
 842.6
Larval Fat Body
 
 795.1
Larval Salivary Gland
 
 436.8
Larval Trachea
 
 700.125
Larval Carcass
 
 326.475
Adult Head
 
 488.1
Adult Eye
 
 846.075
Adult Brain
 
 921.9
Adult Thoracic-Abdominal Ganglion
 
 809
Adult Crop
 
 672.7
Adult Midgut
 
 342.1
Adult Hindgut
 
 570.1
Adult Malpighian Tubules
 
 749.1
Adult Fat Body
 
 528.8
Adult Salivary Gland
 
 406.9
Adult Heart
 
 753.775
Adult VirginFemale Spermatheca
 
 815.7
Adult InseminatedFemale Spermatheca
 
 701.1
Adult Ovary
 
 664.9
Adult Testis
 
 170.9
Adult Male Accessory Gland
 
 407.1
Adult Carcass
 
 443.9
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
Heatmap
Tissue   Expression Level
Larval Central Nervous System
 
 
Larval Midgut
 
 
Larval Hindgut
 
 
Larval Malpighian Tubules
 
 
Larval Fat Body
 
 
Larval Salivary Gland
 
 
Larval Trachea
 
 
Larval Carcass
 
 
Adult Head
 
 
Adult Eye
 
 
Adult Brain
 
 
Adult Thoracic-Abdominal Ganglion
 
 
Adult Crop
 
 
Adult Midgut
 
 
Adult Hindgut
 
 
Adult Malpighian Tubules
 
 
Adult Fat Body
 
 
Adult Salivary Gland
 
 
Adult Heart
 
 
Adult VirginFemale Spermatheca
 
 
Adult InseminatedFemale Spermatheca
 
 
Adult Ovary
 
 
Adult Testis
 
 
Adult Male Accessory Gland
 
 
Adult Carcass
 
 

FlyAtlas Organ/Tissue Expression, larval vs. adult
Larval Expression Level Tissue Adult Expression Level
 
NA 
Head
 
 488.1
 
NA 
Eye
 
 846.075
 
NA 
Brain
 
 921.9
 
943.2 
Central Nervous System
 
 NA
 
NA 
Thoracic-Abdominal Ganglion
 
 809
 
NA 
Crop
 
 672.7
 
430.6 
Midgut
 
 342.1
 
677.2 
Hindgut
 
 570.1
 
842.6 
Malpighian Tubules
 
 749.1
 
795.1 
Fat Body
 
 528.8
 
436.8 
Salivary Gland
 
 406.9
 
NA 
Heart
 
 753.775
 
700.125 
Trachea
 
 NA
 
NA 
VirginFemale Spermatheca
 
 815.7
 
NA 
InseminatedFemale Spermatheca
 
 701.1
 
NA 
Ovary
 
 664.9
 
NA 
Testis
 
 170.9
 
NA 
Male Accessory Gland
 
 407.1
 
326.475 
Carcass
 
 443.9

modENCODE Temporal Expression Data (Graveley et al., 2011)
FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
hide Expression Clusters
A cluster of genes with similar mRNA expression dynamics across development.
hide External Data & Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyExpress - Embryonic expression images (BDGP data)
hide Alleles & Phenotypes
hide Summary of Allele Phenotypes
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
bouton & neuromuscular junction | larval stage, with Scer\GAL4elav.PLu
microtubule & neuromuscular junction | larval stage, with Scer\GAL4elav.PLu
hide Classical Alleles ( 18 )
For All Classical Alleles Show

Allele of mtsClassMutagenStocksKnown lesion
mtsk125023 --
mtss52862 --
mts024961 Yes
mtsc020351 --
mtsEY126381 --
mtsk165011 --
mtsNP0662
1 --
mtsXE-22581 Yes
mts055590 --
mts299hypomorphic allele - genetic evidence
0 Yes
mtsCPTI0036840 Yes
mtsEP24050 --
mtsf045190 --
mtsf054980 --
mtsk060090 --
mtsk098220 Yes
mtsunspecified
0 --
mtsXE-22020 Yes
hide Alleles Carried on Transgenic Constructs ( 11 )
For All Alleles Carried on Transgenic Constructs Show

Allele of mtsClassMutagenStocksKnown lesion
mtsGD121333 Yes
mtsJF028051 Yes
mtsAct5C.T:Ivir\HA10 Yes
mtsDN.Scer\UAS0 Yes
mtsdn165.Scer\UAS0 Yes
mtsdn181.Scer\UAS0 Yes
mtsdn214.Scer\UAS0 Yes
mtsdsRNA.1-6900 Yes
mtsScer\UAS.cHa0 Yes
mtsScer\UAS.cUa0 Yes
mtsScer\UAS.T:Hsap\MYC0 Yes
hide Aneuploid Aberrations
Disrupted in
Not disrupted in
Partially disrupted in
hide Transgenic Constructs & Insertions
Transgenic Constructs
Type of construct
Name
Expression data
Insertions
Type of insertions
Name
Expression data
insertion of mobile activating element
insertion of enhancer trap binary system
hide Gene Ontology: Function, Process & Cellular Component ( 25 unique terms )
hide Terms Based on Experimental Evidence ( 24 terms )
Molecular Function
CV term
References
Biological Process
CV term
References
inferred from mutant phenotype
inferred from genetic interaction with l(2)gl
inferred from genetic interaction with par-6
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from genetic interaction with hh
inferred from genetic interaction with smo
inferred from mutant phenotype
inferred from genetic interaction with Ras85D
inferred from mutant phenotype
inferred from genetic interaction with inaC
inferred from mutant phenotype
inferred from mutant phenotype
Cellular Component
CV term
References
hide Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term
References
Biological Process
CV term
References
Cellular Component
CV term
References
inferred from sequence or structural similarity
hide Sequence Ontology: Class of Gene
hide Interactions & Pathways
hide Summary of Physical Interactions
Protein-protein
Interacting group
Assay
References
hide Summary of Genetic Interactions
Interacts with
Please look at the allele data for full details of the genetic interactions
mts allele
Gene
References
hide External Data
Linkouts
BioGRID - A database of protein and genetic interactions
DPiM - DPiM, Drosophila Protein interaction Map
DroID - A comprehensive database of gene and protein interactions.
InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.
hide Orthologs
Genome-wide drosophilid orthologs
Curated drosophilid orthologs
Linkouts
InParanoid A subset of ortholog calls from InParanoid.
OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs.
hide Stocks & Reagents
hide Stocks Listed in FlyBase ( 15 )
Bloomington
Harvard
Kyoto
VDRC
hide Genomic Clones ( 3 )
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
hide cDNA Clones ( 178 )
Please Note
This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
hide RNAi & Array Information
Linkouts
DRSC - Results from RNAi screens.
GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
hide Antibody Information
hide Other Information
hide Discoverer
hide Etymology
hide Identification
hide Relationship to Other Genes
Source for database identity of
Source for database merge of
Source for merge of: mts CG7109
Additional comments
hide Other Comments
mts is required for efficient recruitment of pericentriolar material.
dsRNA directed against this gene has been used in a screen for genes required for constitutive protein secretion.
S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.
Identified as a potential component of the hh signalling pathway in a genome-wide RNAi screen. dsRNA made from templates generated with primers directed affects the extent of expression of a hh signaling reporter construct in Clone 8 cells.
RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in Kc167 cells: change from round to spindle-shaped, with the formation of F-actin puncta and microtubule extensions. Alterations of cell shape are also evident in S2R+ cells; cells become round and detached.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
Identification: Enhancer trap expression pattern survey for loci expressed in the ring gland.
Lack of mts causes a block in mitosis and uncouples the centrosome cycle from the nuclear cycle and prevents the attachment of microtubules to the kinetochore.
Encodes the catalytic subunit of PP2A.
The mts product positively and negatively regulates Ras85D-mediated photoreceptor development.
A screen to identify mutations affecting the Ras85D signalling pathway identified alleles of phl, Dsor1, rl, aop, βggt-I, mts, ksr and phyl.
mts has been molecularly cloned and developmental expression patterns examined.
A mts cDNA has been cloned and sequenced.
hide External Crossreferences & Linkouts
Sequence Crossreferences
RefSeq (Transcripts)
RefSeq (Proteins)
Entrez Gene - A searchable database of RefSeq genes.
Other Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
Linkouts
BioGRID - A database of protein and genetic interactions
DPiM - DPiM, Drosophila Protein interaction Map
DroID - A comprehensive database of gene and protein interactions.
DRSC - Results from RNAi screens.
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans
FlyReactome - A curated knowledgebase of Drosophila melanogaster pathways
GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
InParanoid A subset of ortholog calls from InParanoid.
InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.
modMine - Data generated by the modENCODE project.
OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs.
hide Synonyms & Secondary IDs ( 29 )
Reported As
Symbol Synonym
DmPp2A-28D
l(2)02496
 
l(2)s5286
 
Pp2A-28D
Name Synonym
catalytic subunit C of type 2A protein phosphatase
phosphatase 2A catalytic subunit
protein phosphatase 2A
Protein phosphatase 2A at 28D
 
Secondary FlyBase IDs
  • FBgn0010514
  • FBgn0010703
  • FBgn0031953
hide References ( 131 )
Generate a list of
List References by type
hide Recent research papers ( 11 )
Booker et al., 2011, BMC Genomics 12: 50
False negative rates in Drosophila cell-based RNAi screens: a case study. [FBrf0212969]
Horn et al., 2011, Nat. Methods 8(4): 341--346
Mapping of signaling networks through synthetic genetic interaction analysis by RNAi. [FBrf0213352]
Maher et al., 2011, Hum. Mol. Genet. 20(2): 261--270
ERK activation by the polyphenols fisetin and resveratrol provides neuroprotection in multiple models of Huntington's disease. [FBrf0212618]
Rangone et al., 2011, PLoS Genet. 7(8): e1002225
Suppression of Scant Identifies Endos as a Substrate of Greatwall Kinase and a Negative Regulator of Protein Phosphatase 2A in Mitosis. [FBrf0214749]
Su et al., 2011, Sci. Signal. 4(180): ra43
Sequential phosphorylation of smoothened transduces graded hedgehog signaling. [FBrf0216577]
Wang et al., 2011, PLoS Genet. 7(8): e1002227
PP2A-Twins Is Antagonized by Greatwall and Collaborates with Polo for Cell Cycle Progression and Centrosome Attachment to Nuclei in Drosophila Embryos. [FBrf0214683]
Chang et al., 2010, Dev. Cell 19(5): 778--785
Interplay between the Transcription Factor Zif and aPKC Regulates Neuroblast Polarity and Self-Renewal. [FBrf0212286]
Müller et al., 2010, EMBO J. 29(19): 3344--3357
Proteomic and functional analysis of the mitotic Drosophila centrosome. [FBrf0212030]
Ribeiro et al., 2010, Mol. Cell 39(4): 521--534
Combined Functional Genomic and Proteomic Approaches Identify a PP2A Complex as a Negative Regulator of Hippo Signaling. [FBrf0211636]
Salzer et al., 2010, Genetics 184(1): 185--197
The retinal determination gene eyes absent is regulated by the EGF receptor pathway throughout development in Drosophila. [FBrf0209690]
Serio et al., 2010, Cell Host Microbe 7(5): 388--398
Defining a Core Set of Actin Cytoskeletal Proteins Critical for Actin-Based Motility of Rickettsia. [FBrf0210774]
hide Recent reviews (0)
All reviews listed in FlyBase were published before 2010