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Gene Dmel\mts

General Information
Symbol	Dmel\mts	Species	D. melanogaster
Name	microtubule star	Annotation symbol	CG7109
Feature type	protein_coding_gene	FlyBase ID	FBgn0004177
Gene Model Status	Current	Stock availability	16 publicly available
Also Known As	PP2a, PP2a 28D, PP2A-C, PP2, PP2Ac, MTS/PP2A, dPP2A, PP2A C
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	28D1-28D2	Sequence location	2L:7,827,743..7,832,745 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene microtubule star is referred to in FlyBase by the symbol Dmel\mts (CG7109, FBgn0004177). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: phosphatase regulator activity; protein serine/threonine phosphatase activity. There is experimental evidence for 22 unique biological process terms, many of which group under: cellular component organization or biogenesis; cell cycle; biological regulation; organelle organization; cell cycle process; regulation of developmental process; cell fate commitment; response to stimulus; response to light stimulus; macromolecule modification; sensory organ development; multicellular organism reproduction. 30 alleles are reported. The phenotypes of these alleles are annotated with: eye; embryonic/larval brain; wing hair; embryonic/larval neuroblast. It has one annotated transcript and one annotated polypeptide. Protein features are: Metallophosphoesterase domain; Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of high expression. Peak expression observed within 00-18 hour embryonic stages, during late larval stages, during early pupal stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, adult crop, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval trachea, adult female reproductive system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult midgut, larval/adult salivary gland, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1640841_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of mts. Gene sequence location is 2L:7827743..7832745.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 28D1-28D2   Limits computationally determined from genome sequence between P{EP}EP2178 and P{PZ}mts02496
Experimentally Determined Cytological Location
Cytogenetic map Notes References 28D1-28D2   (determined by in situ hybridisation)   (Spradling et al., 1999) 28D-28D   (determined by in situ hybridisation)   (Snaith et al., 1996) 28D1-28D2   (determined by in situ hybridisation)   (Wassarman et al., 1996) 28D2-28D4   (determined by in situ hybridisation)   (Mayer-Jaekel and Hemmings, 1995) 28D1-28D2     (BDGP Project Members, 1994-1999) 28D2-28D4   (determined by in situ hybridisation)   (Orgad et al., 1990)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\mts for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) mts-RA FBtr0079525  NM_057457   2178   309
Additional Transcript Data & Comments
Reported size (kB)	2.5, 1.6 (northern blot) (Mayer-Jaekel et al., 1992) 2.3, 1.5 (northern blot) (Orgad et al., 1990)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein mts-PA   FBpp0079148   35.5   309   4.97     NP_476805   AAF52567
Additional Polypeptide Data & Comments
Reported size (kDa)	309 (aa); 35.42 (kD predicted) (Orgad et al., 1990)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Metallophosphoesterase domain (IPR004843) Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase (IPR006186)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201617   AA264005   AA264326   AA391144   AA438543   AA438789   AA440920   AA567166   AA695313   AA696382   AA820727   AA820796   AA821000   AA942060   AA942428   AA948912   AA950630   AA950636   AA950857   AA990855   AE014134 AAF52567   AC004723   AC008328   AI108245   AI134422   AI134800   AI134809   AI258458   AI258699   AI259178   AI259231   AI294985   AI295405   AI296894   AI297293   AI405071   AI514825   AI515352   AI515924   AI517764   AI531017   AI546297   AQ073559   AW942828   AY058571 AAL13800   AY431529   AY439457   BE978204   BI162245   BI162246   BI165609   BI238045   BI238766   BI242683   BI354349   BI357059   BI357572   BI363803   BI364369   BI365367   BI365955   BI369212   BI375472   BI375909   BI481763   BI483486   BI484893   BI571068   BI580606   BI590713   BI591716   BI592981   BI605319   BI607882   BI607932   BI610067   BI613187   BI623687   BI626867   BI628132   BI637673   BI640664   BI641787   BP546261   BP549292   BP549293   BP550605   BP555794   BP555795   BP555983   BX033649   BX051433   BX051575   BX055549   BX059795   BX062834   CA804505   CA806211   CA807661   CA807786   CK132045   CK657344   CK662135   CL868585   CO152860   CO153347   CO153630   CO156367   CO156662   CO157098   CO177758   CO184758   CO264075   CO264750   CO269201   CO274930   CO276902   CO278324   CO279986   CO280631   CO281380   CO282684   CO283290   CO283460   CO284450   CO286265   CO293791   CO295272   CO296913   CO298436   CO299780   CO307068   CO307081   CO315066   CO317736   CO320600   CO323786   CO325490   CO328303   CO329919   CO332369   CO332763   CO334077   CZ467633   CZ487054   CZ488088   CZ488089   DN154215   EC051561   EC055097   EC061758   EC063443   EC063555   EC065544   EC066064   EC073002   EC073542   EC079245   EC082588   EC084808   EC090099   EC203551   EC204196   EC205167   EC205458   EC205667   EC206643   EC208862   EC209725   EC210005   EC210768   EC215629   EC220562   EC221255   EC224845   EC233020   EC233989   EC238678   EC238723   EC239381   EC246649   EC256621   EC261792   EC262129   EC264563   EC264965   EC265389   EC265814   EL884707   ES692827   ES694326   EV576490   EV579376   EV580056   EV582782   EV586140   EV586834   EV588486   EV592169   EV598103   EV598983   G01458   X55199 CAA38984   X78577 CAA55315
UniProtKB/Swiss-Prot	P23696
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic brain   (Fisher et al., 2012) embryonic/larval midgut   (Fisher et al., 2012) embryonic/larval nervous system   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage | early     (Mayer-Jaekel et al., 1992) embryonic stage & larval stage     (Mayer-Jaekel et al., 1992) embryonic stage & larval stage & adult stage     (Mayer-Jaekel et al., 1992) embryonic stage -- adult stage     (Orgad et al., 1990) radioisotope in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage | early   organism | ubiquitous   (Mayer-Jaekel et al., 1992) embryonic stage | late   gonad   (Mayer-Jaekel et al., 1992) ventral nerve cord   (Mayer-Jaekel et al., 1992) supraesophageal ganglion   (Mayer-Jaekel et al., 1992) embryonic stage   organism | ubiquitous   (Mayer-Jaekel et al., 1992) embryonic stage 9 -- 11   neuroblast   (Mayer-Jaekel et al., 1992) third instar larval stage   embryonic/larval salivary gland   (Mayer-Jaekel et al., 1992) embryonic/larval brain   (Mayer-Jaekel et al., 1992) imaginal disc   (Mayer-Jaekel et al., 1992) adult stage   adult brain   (Mayer-Jaekel et al., 1992) adult midgut   (Mayer-Jaekel et al., 1992) adult stage & oogenesis   nurse cell   (Mayer-Jaekel et al., 1992) oocyte   (Mayer-Jaekel et al., 1992)
Additional Descriptive Data
	The 2.3kb mts transcript is strongly expressed in early embryos and is reduced ~20fold in late embryos and larvae. (Mayer-Jaekel et al., 1992) The 1.5kb mts transcript is strongly expressed in eary embryos and decreases about 60% in late embryos and larvae. It is also detected in adults. (Mayer-Jaekel et al., 1992) Expression was observed in cryostat sections at several different stages of development. In adult females, basal levels of Pp2A-29B transcripts are detected in all tissues. High levels of expression are observed in the ovary in the nurse cells and oocytes. Slightly elevated levels are observed in the brain and the gut. In early embryos, transcripts are evenly distributed at high levels. In later embryos, the levels decline but slightly higher levels are seen in the developing CNS than in surrounding tissue. In third instar larvae, transcripts are enriched in the supraesophageal ganglion but are at very low levels in the neuropil. Elevated levels are observed in imaginal discs and salivary glands. In early embryos, in situ hybridization reveals uniform expression. Enrichment is observed in neuroblasts at germ band extension and in the ventral nerve cord and supraesophageal ganglion at later embryonic stages. In addition elevated levels are observed in the gonads. (Mayer-Jaekel et al., 1992) The 2.3 and 1.5 kb mts transcripts are expressed throughout development. Expression is especially high in 0-4 hr embryos. (Orgad et al., 1990)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
	Pp2A-29B and mts proteins show the same cytoplasmic localization in embryos and imaginal discs as the tws protein. In syncytial blastoderm embryos the protein is found in the cytoplasmic region surrounding the cortical layer of nuclei. The protein is cytoplasmic in pole cells. In cycle 14 embryos, the protein is located throughout the cytoplasm of interphase cells, and throughout the whole cell as it progresses through mitosis. In dividing third larval instar brain neuroblasts, the protein is detected in the cytoplasm of interphase and mitotic cells. (Mayer-Jaekel et al., 1994)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
centriole inferred from direct assay (Dobbelaere et al., 2008) cytoplasm inferred from direct assay (Chabu and Doe, 2009, Mayer-Jaekel et al., 1994, Dobbelaere et al., 2008)
Expression Deduced from Reporters
Reporter: P{PZ}mts02496 Stage Tissue/Position (including subcellular localization) Reference wandering third instar larval stage   imaginal disc   (Meister and Braun, 1995.10) embryonic/larval brain   (Meister and Braun, 1995.10)
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, adult crop, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval trachea, adult female reproductive system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult midgut, larval/adult salivary gland, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    943.2 Larval Midgut    430.6 Larval Hindgut    677.2 Larval Malpighian Tubules    842.6 Larval Fat Body    795.1 Larval Salivary Gland    436.8 Larval Trachea    700.125 Larval Carcass    326.475 Adult Head    488.1 Adult Eye    846.075 Adult Brain    921.9 Adult Thoracic-Abdominal Ganglion    809 Adult Crop    672.7 Adult Midgut    342.1 Adult Hindgut    570.1 Adult Malpighian Tubules    749.1 Adult Fat Body    528.8 Adult Salivary Gland    406.9 Adult Heart    753.775 Adult VirginFemale Spermatheca    815.7 Adult InseminatedFemale Spermatheca    701.1 Adult Ovary    664.9 Adult Testis    170.9 Adult Male Accessory Gland    407.1 Adult Carcass    443.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (943.2) Larval Midgut    430.6 Larval Hindgut  (677.2) Larval Malpighian Tubules  (842.6) Larval Fat Body  (795.1) Larval Salivary Gland    436.8 Larval Trachea  (700.125) Larval Carcass    326.475 Adult Head    488.1 Adult Eye  (846.075) Adult Brain  (921.9) Adult Thoracic-Abdominal Ganglion  (809) Adult Crop  (672.7) Adult Midgut    342.1 Adult Hindgut  (570.1) Adult Malpighian Tubules  (749.1) Adult Fat Body  528.8 Adult Salivary Gland    406.9 Adult Heart  (753.775) Adult VirginFemale Spermatheca  (815.7) Adult InseminatedFemale Spermatheca  (701.1) Adult Ovary  (664.9) Adult Testis    170.9 Adult Male Accessory Gland    407.1 Adult Carcass    443.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    943.2 Larval Midgut    430.6 Larval Hindgut    677.2 Larval Malpighian Tubules    842.6 Larval Fat Body    795.1 Larval Salivary Gland    436.8 Larval Trachea    700.125 Larval Carcass    326.475 Adult Head    488.1 Adult Eye    846.075 Adult Brain    921.9 Adult Thoracic-Abdominal Ganglion    809 Adult Crop    672.7 Adult Midgut    342.1 Adult Hindgut    570.1 Adult Malpighian Tubules    749.1 Adult Fat Body    528.8 Adult Salivary Gland    406.9 Adult Heart    753.775 Adult VirginFemale Spermatheca    815.7 Adult InseminatedFemale Spermatheca    701.1 Adult Ovary    664.9 Adult Testis    170.9 Adult Male Accessory Gland    407.1 Adult Carcass    443.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    943.2 Larval Midgut    430.6 Larval Hindgut    677.2 Larval Malpighian Tubules    842.6 Larval Fat Body    795.1 Larval Salivary Gland    436.8 Larval Trachea    700.125 Larval Carcass    326.475 Adult Head    488.1 Adult Eye    846.075 Adult Brain    921.9 Adult Thoracic-Abdominal Ganglion    809 Adult Crop    672.7 Adult Midgut    342.1 Adult Hindgut    570.1 Adult Malpighian Tubules    749.1 Adult Fat Body    528.8 Adult Salivary Gland    406.9 Adult Heart    753.775 Adult VirginFemale Spermatheca    815.7 Adult InseminatedFemale Spermatheca    701.1 Adult Ovary    664.9 Adult Testis    170.9 Adult Male Accessory Gland    407.1 Adult Carcass    443.9 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    943.2 Larval Midgut    430.6 Larval Hindgut    677.2 Larval Malpighian Tubules    842.6 Larval Fat Body    795.1 Larval Salivary Gland    436.8 Larval Trachea    700.125 Larval Carcass    326.475 Adult Head    488.1 Adult Eye    846.075 Adult Brain    921.9 Adult Thoracic-Abdominal Ganglion    809 Adult Crop    672.7 Adult Midgut    342.1 Adult Hindgut    570.1 Adult Malpighian Tubules    749.1 Adult Fat Body    528.8 Adult Salivary Gland    406.9 Adult Heart    753.775 Adult VirginFemale Spermatheca    815.7 Adult InseminatedFemale Spermatheca    701.1 Adult Ovary    664.9 Adult Testis    170.9 Adult Male Accessory Gland    407.1 Adult Carcass    443.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (943.2) Larval Midgut    430.6 Larval Hindgut  677.2 Larval Malpighian Tubules  (842.6) Larval Fat Body  795.1 Larval Salivary Gland    436.8 Larval Trachea  700.125 Larval Carcass    326.475 Adult Head    488.1 Adult Eye  (846.075) Adult Brain  (921.9) Adult Thoracic-Abdominal Ganglion  809 Adult Crop  672.7 Adult Midgut    342.1 Adult Hindgut  570.1 Adult Malpighian Tubules  749.1 Adult Fat Body  528.8 Adult Salivary Gland    406.9 Adult Heart  753.775 Adult VirginFemale Spermatheca  (815.7) Adult InseminatedFemale Spermatheca  701.1 Adult Ovary  664.9 Adult Testis    170.9 Adult Male Accessory Gland    407.1 Adult Carcass    443.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    943.2 Larval Midgut    430.6 Larval Hindgut    677.2 Larval Malpighian Tubules    842.6 Larval Fat Body    795.1 Larval Salivary Gland    436.8 Larval Trachea    700.125 Larval Carcass    326.475 Adult Head    488.1 Adult Eye    846.075 Adult Brain    921.9 Adult Thoracic-Abdominal Ganglion    809 Adult Crop    672.7 Adult Midgut    342.1 Adult Hindgut    570.1 Adult Malpighian Tubules    749.1 Adult Fat Body    528.8 Adult Salivary Gland    406.9 Adult Heart    753.775 Adult VirginFemale Spermatheca    815.7 Adult InseminatedFemale Spermatheca    701.1 Adult Ovary    664.9 Adult Testis    170.9 Adult Male Accessory Gland    407.1 Adult Carcass    443.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    943.2 Larval Midgut    430.6 Larval Hindgut    677.2 Larval Malpighian Tubules    842.6 Larval Fat Body    795.1 Larval Salivary Gland    436.8 Larval Trachea    700.125 Larval Carcass    326.475 Adult Head    488.1 Adult Eye    846.075 Adult Brain    921.9 Adult Thoracic-Abdominal Ganglion    809 Adult Crop    672.7 Adult Midgut    342.1 Adult Hindgut    570.1 Adult Malpighian Tubules    749.1 Adult Fat Body    528.8 Adult Salivary Gland    406.9 Adult Heart    753.775 Adult VirginFemale Spermatheca    815.7 Adult InseminatedFemale Spermatheca    701.1 Adult Ovary    664.9 Adult Testis    170.9 Adult Male Accessory Gland    407.1 Adult Carcass    443.9 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    488.1   NA  Eye    846.075   NA  Brain    921.9   943.2  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    809   NA  Crop    672.7   430.6  Midgut    342.1   677.2  Hindgut    570.1   842.6  Malpighian Tubules    749.1   795.1  Fat Body    528.8   436.8  Salivary Gland    406.9   NA  Heart    753.775   700.125  Trachea    NA   NA  VirginFemale Spermatheca    815.7   NA  InseminatedFemale Spermatheca    701.1   NA  Ovary    664.9   NA  Testis    170.9   NA  Male Accessory Gland    407.1   326.475  Carcass    443.9 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    195 central nervous system, larvae L3    326 central nervous system, pupae P8    303 head, virgin 1-day female    142 head, virgin 4-day female    136 head, virgin 20-day female    74 head, mated 1-day female    167 head, mated 4-day female    152 head, mated 20-day female    84 head, mated 1-day male    138 head, mated 4-day male    210 head, mated 20-day male    162 salivary gland, larvae L3 wandering    78 salivary gland, white prepupae    163 digestive system, larvae L3 wandering    206 digestive system, 1-day adult    165 digestive system, 4-day adult    228 digestive system, 20-day adult    116 fat body, larvae L3 wandering    128 fat body, white prepupae    172 fat body, pupae P8    200 carcass, larvae L3 wandering    187 carcass, 1-day adult    112 carcass, 4-day adult    132 carcass, 20-day adult    89 ovary, virgin 4-day female    287 ovary, mated 4-day female    361 testis, mated 4-day male    51 accessory gland, mated 4-day male    67 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (195) central nervous system, larvae L3  (326) central nervous system, pupae P8  (303) head, virgin 1-day female  (142) head, virgin 4-day female  (136) head, virgin 20-day female  (74) head, mated 1-day female  (167) head, mated 4-day female  (152) head, mated 20-day female  (84) head, mated 1-day male  (138) head, mated 4-day male  (210) head, mated 20-day male  (162) salivary gland, larvae L3 wandering  (78) salivary gland, white prepupae  (163) digestive system, larvae L3 wandering  (206) digestive system, 1-day adult  (165) digestive system, 4-day adult  (228) digestive system, 20-day adult  (116) fat body, larvae L3 wandering  (128) fat body, white prepupae  (172) fat body, pupae P8  (200) carcass, larvae L3 wandering  (187) carcass, 1-day adult  (112) carcass, 4-day adult  (132) carcass, 20-day adult  (89) ovary, virgin 4-day female  (287) ovary, mated 4-day female  (361) testis, mated 4-day male  (51) accessory gland, mated 4-day male  (67) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (195) central nervous system, larvae L3  (326) central nervous system, pupae P8  (303) head, virgin 1-day female  (142) head, virgin 4-day female  (136) head, virgin 20-day female    74 head, mated 1-day female  (167) head, mated 4-day female  (152) head, mated 20-day female    84 head, mated 1-day male  (138) head, mated 4-day male  (210) head, mated 20-day male  (162) salivary gland, larvae L3 wandering    78 salivary gland, white prepupae  (163) digestive system, larvae L3 wandering  (206) digestive system, 1-day adult  (165) digestive system, 4-day adult  (228) digestive system, 20-day adult  (116) fat body, larvae L3 wandering  (128) fat body, white prepupae  (172) fat body, pupae P8  (200) carcass, larvae L3 wandering  (187) carcass, 1-day adult  (112) carcass, 4-day adult  (132) carcass, 20-day adult    89 ovary, virgin 4-day female  (287) ovary, mated 4-day female  (361) testis, mated 4-day male    51 accessory gland, mated 4-day male    67 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    195 central nervous system, larvae L3    326 central nervous system, pupae P8    303 head, virgin 1-day female    142 head, virgin 4-day female    136 head, virgin 20-day female    74 head, mated 1-day female    167 head, mated 4-day female    152 head, mated 20-day female    84 head, mated 1-day male    138 head, mated 4-day male    210 head, mated 20-day male    162 salivary gland, larvae L3 wandering    78 salivary gland, white prepupae    163 digestive system, larvae L3 wandering    206 digestive system, 1-day adult    165 digestive system, 4-day adult    228 digestive system, 20-day adult    116 fat body, larvae L3 wandering    128 fat body, white prepupae    172 fat body, pupae P8    200 carcass, larvae L3 wandering    187 carcass, 1-day adult    112 carcass, 4-day adult    132 carcass, 20-day adult    89 ovary, virgin 4-day female    287 ovary, mated 4-day female    361 testis, mated 4-day male    51 accessory gland, mated 4-day male    67 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    195 central nervous system, larvae L3    326 central nervous system, pupae P8    303 head, virgin 1-day female    142 head, virgin 4-day female    136 head, virgin 20-day female    74 head, mated 1-day female    167 head, mated 4-day female    152 head, mated 20-day female    84 head, mated 1-day male    138 head, mated 4-day male    210 head, mated 20-day male    162 salivary gland, larvae L3 wandering    78 salivary gland, white prepupae    163 digestive system, larvae L3 wandering    206 digestive system, 1-day adult    165 digestive system, 4-day adult    228 digestive system, 20-day adult    116 fat body, larvae L3 wandering    128 fat body, white prepupae    172 fat body, pupae P8    200 carcass, larvae L3 wandering    187 carcass, 1-day adult    112 carcass, 4-day adult    132 carcass, 20-day adult    89 ovary, virgin 4-day female    287 ovary, mated 4-day female    361 testis, mated 4-day male    51 accessory gland, mated 4-day male    67 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (195) central nervous system, larvae L3  (326) central nervous system, pupae P8  (303) head, virgin 1-day female  (142) head, virgin 4-day female  (136) head, virgin 20-day female  (74) head, mated 1-day female  (167) head, mated 4-day female  (152) head, mated 20-day female  (84) head, mated 1-day male  (138) head, mated 4-day male  (210) head, mated 20-day male  (162) salivary gland, larvae L3 wandering  (78) salivary gland, white prepupae  (163) digestive system, larvae L3 wandering  (206) digestive system, 1-day adult  (165) digestive system, 4-day adult  (228) digestive system, 20-day adult  (116) fat body, larvae L3 wandering  (128) fat body, white prepupae  (172) fat body, pupae P8  (200) carcass, larvae L3 wandering  (187) carcass, 1-day adult  (112) carcass, 4-day adult  (132) carcass, 20-day adult  (89) ovary, virgin 4-day female  (287) ovary, mated 4-day female  (361) testis, mated 4-day male  (51) accessory gland, mated 4-day male  (67) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (195) central nervous system, larvae L3  (326) central nervous system, pupae P8  (303) head, virgin 1-day female  142 head, virgin 4-day female  136 head, virgin 20-day female    74 head, mated 1-day female  (167) head, mated 4-day female  (152) head, mated 20-day female    84 head, mated 1-day male  138 head, mated 4-day male  (210) head, mated 20-day male  (162) salivary gland, larvae L3 wandering    78 salivary gland, white prepupae  (163) digestive system, larvae L3 wandering  (206) digestive system, 1-day adult  (165) digestive system, 4-day adult  (228) digestive system, 20-day adult  116 fat body, larvae L3 wandering  128 fat body, white prepupae  (172) fat body, pupae P8  (200) carcass, larvae L3 wandering  (187) carcass, 1-day adult  112 carcass, 4-day adult  132 carcass, 20-day adult    89 ovary, virgin 4-day female  (287) ovary, mated 4-day female  (361) testis, mated 4-day male    51 accessory gland, mated 4-day male    67 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    195 central nervous system, larvae L3    326 central nervous system, pupae P8    303 head, virgin 1-day female    142 head, virgin 4-day female    136 head, virgin 20-day female    74 head, mated 1-day female    167 head, mated 4-day female    152 head, mated 20-day female    84 head, mated 1-day male    138 head, mated 4-day male    210 head, mated 20-day male    162 salivary gland, larvae L3 wandering    78 salivary gland, white prepupae    163 digestive system, larvae L3 wandering    206 digestive system, 1-day adult    165 digestive system, 4-day adult    228 digestive system, 20-day adult    116 fat body, larvae L3 wandering    128 fat body, white prepupae    172 fat body, pupae P8    200 carcass, larvae L3 wandering    187 carcass, 1-day adult    112 carcass, 4-day adult    132 carcass, 20-day adult    89 ovary, virgin 4-day female    287 ovary, mated 4-day female    361 testis, mated 4-day male    51 accessory gland, mated 4-day male    67 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of high expression. Peak expression observed within 00-18 hour embryonic stages, during late larval stages, during early pupal stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    273 embryo 02-04hr    380 embryo 04-06hr    313 embryo 06-08hr    293 embryo 08-10hr    275 embryo 10-12hr    252 embryo 12-14hr    178 embryo 14-16hr    137 embryo 16-18hr    135 embryo 18-20hr    125 embryo 20-22hr    124 embryo 22-24hr    131 larva L1    110 larva L2    109 larva L3 12hr old    102 larva L3 puffstage 1-2    108 larva L3 puffstage 3-6    138 larva L3 puffstage 7-9    182 white prepupae new    171 white prepupae 12hr    154 white prepupae 24hr    172 pupae 2d postWPP    130 pupae 3d postWPP    99 pupae 4d postWPP    124 adult male 01day    79 adult male 05day    76 adult male 30day    68 adult female 01day    119 adult female 05day    170 adult female 30day    168 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (273) embryo 02-04hr  (380) embryo 04-06hr  (313) embryo 06-08hr  (293) embryo 08-10hr  (275) embryo 10-12hr  (252) embryo 12-14hr  (178) embryo 14-16hr  (137) embryo 16-18hr  (135) embryo 18-20hr  (125) embryo 20-22hr  (124) embryo 22-24hr  (131) larva L1  (110) larva L2  (109) larva L3 12hr old  (102) larva L3 puffstage 1-2  (108) larva L3 puffstage 3-6  (138) larva L3 puffstage 7-9  (182) white prepupae new  (171) white prepupae 12hr  (154) white prepupae 24hr  (172) pupae 2d postWPP  (130) pupae 3d postWPP  (99) pupae 4d postWPP  (124) adult male 01day  (79) adult male 05day  (76) adult male 30day  (68) adult female 01day  (119) adult female 05day  (170) adult female 30day  (168) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (273) embryo 02-04hr  (380) embryo 04-06hr  (313) embryo 06-08hr  (293) embryo 08-10hr  (275) embryo 10-12hr  (252) embryo 12-14hr  (178) embryo 14-16hr  (137) embryo 16-18hr  (135) embryo 18-20hr  (125) embryo 20-22hr  (124) embryo 22-24hr  (131) larva L1  (110) larva L2  (109) larva L3 12hr old  102 larva L3 puffstage 1-2  (108) larva L3 puffstage 3-6  (138) larva L3 puffstage 7-9  (182) white prepupae new  (171) white prepupae 12hr  (154) white prepupae 24hr  (172) pupae 2d postWPP  (130) pupae 3d postWPP    99 pupae 4d postWPP  (124) adult male 01day    79 adult male 05day    76 adult male 30day    68 adult female 01day  (119) adult female 05day  (170) adult female 30day  (168) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    273 embryo 02-04hr    380 embryo 04-06hr    313 embryo 06-08hr    293 embryo 08-10hr    275 embryo 10-12hr    252 embryo 12-14hr    178 embryo 14-16hr    137 embryo 16-18hr    135 embryo 18-20hr    125 embryo 20-22hr    124 embryo 22-24hr    131 larva L1    110 larva L2    109 larva L3 12hr old    102 larva L3 puffstage 1-2    108 larva L3 puffstage 3-6    138 larva L3 puffstage 7-9    182 white prepupae new    171 white prepupae 12hr    154 white prepupae 24hr    172 pupae 2d postWPP    130 pupae 3d postWPP    99 pupae 4d postWPP    124 adult male 01day    79 adult male 05day    76 adult male 30day    68 adult female 01day    119 adult female 05day    170 adult female 30day    168 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    273 embryo 02-04hr    380 embryo 04-06hr    313 embryo 06-08hr    293 embryo 08-10hr    275 embryo 10-12hr    252 embryo 12-14hr    178 embryo 14-16hr    137 embryo 16-18hr    135 embryo 18-20hr    125 embryo 20-22hr    124 embryo 22-24hr    131 larva L1    110 larva L2    109 larva L3 12hr old    102 larva L3 puffstage 1-2    108 larva L3 puffstage 3-6    138 larva L3 puffstage 7-9    182 white prepupae new    171 white prepupae 12hr    154 white prepupae 24hr    172 pupae 2d postWPP    130 pupae 3d postWPP    99 pupae 4d postWPP    124 adult male 01day    79 adult male 05day    76 adult male 30day    68 adult female 01day    119 adult female 05day    170 adult female 30day    168 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (273) embryo 02-04hr  (380) embryo 04-06hr  (313) embryo 06-08hr  (293) embryo 08-10hr  (275) embryo 10-12hr  (252) embryo 12-14hr  (178) embryo 14-16hr  (137) embryo 16-18hr  (135) embryo 18-20hr  (125) embryo 20-22hr  (124) embryo 22-24hr  (131) larva L1  (110) larva L2  (109) larva L3 12hr old  (102) larva L3 puffstage 1-2  (108) larva L3 puffstage 3-6  (138) larva L3 puffstage 7-9  (182) white prepupae new  (171) white prepupae 12hr  (154) white prepupae 24hr  (172) pupae 2d postWPP  (130) pupae 3d postWPP  (99) pupae 4d postWPP  (124) adult male 01day  (79) adult male 05day  (76) adult male 30day  (68) adult female 01day  (119) adult female 05day  (170) adult female 30day  (168) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (273) embryo 02-04hr  (380) embryo 04-06hr  (313) embryo 06-08hr  (293) embryo 08-10hr  (275) embryo 10-12hr  (252) embryo 12-14hr  (178) embryo 14-16hr  137 embryo 16-18hr  135 embryo 18-20hr  125 embryo 20-22hr  124 embryo 22-24hr  131 larva L1  110 larva L2  109 larva L3 12hr old  102 larva L3 puffstage 1-2  108 larva L3 puffstage 3-6  138 larva L3 puffstage 7-9  (182) white prepupae new  (171) white prepupae 12hr  (154) white prepupae 24hr  (172) pupae 2d postWPP  130 pupae 3d postWPP    99 pupae 4d postWPP  124 adult male 01day    79 adult male 05day    76 adult male 30day    68 adult female 01day  119 adult female 05day  (170) adult female 30day  (168) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    273 embryo 02-04hr    380 embryo 04-06hr    313 embryo 06-08hr    293 embryo 08-10hr    275 embryo 10-12hr    252 embryo 12-14hr    178 embryo 14-16hr    137 embryo 16-18hr    135 embryo 18-20hr    125 embryo 20-22hr    124 embryo 22-24hr    131 larva L1    110 larva L2    109 larva L3 12hr old    102 larva L3 puffstage 1-2    108 larva L3 puffstage 3-6    138 larva L3 puffstage 7-9    182 white prepupae new    171 white prepupae 12hr    154 white prepupae 24hr    172 pupae 2d postWPP    130 pupae 3d postWPP    99 pupae 4d postWPP    124 adult male 01day    79 adult male 05day    76 adult male 30day    68 adult female 01day    119 adult female 05day    170 adult female 30day    168 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    261 Schneider line 2 Sg4    350 embryonic 1182-4H    219 embryonic GM2    254 embryonic Kc167    322 embryonic S1    335 embryonic S3    341 leg disc CME L1    247 wing disc CME-W2    260 wing disc ML-DmD8    274 wing disc ML-DmD9    240 wing disc ML-DmD16-c3    514 wing disc ML-DmD21    474 wing disc ML-DmD32    348 haltere disc ML-DmD17-c3    446 eye-antennal disc ML-DmD11    196 antennal disc ML-DmD20-c5    255 mixed discs ML-DmD4-c1    502 CNS ML-DmBG1-c1    350 CNS ML-DmBG2-c2    325 tumorous blood cells mbn2    400 ovary fGS/OSS    369 ovary OSC    525 ovary OSS    340 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (261) Schneider line 2 Sg4  (350) embryonic 1182-4H  (219) embryonic GM2  (254) embryonic Kc167  (322) embryonic S1  (335) embryonic S3  (341) leg disc CME L1  (247) wing disc CME-W2  (260) wing disc ML-DmD8  (274) wing disc ML-DmD9  (240) wing disc ML-DmD16-c3  (514) wing disc ML-DmD21  (474) wing disc ML-DmD32  (348) haltere disc ML-DmD17-c3  (446) eye-antennal disc ML-DmD11  (196) antennal disc ML-DmD20-c5  (255) mixed discs ML-DmD4-c1  (502) CNS ML-DmBG1-c1  (350) CNS ML-DmBG2-c2  (325) tumorous blood cells mbn2  (400) ovary fGS/OSS  (369) ovary OSC  (525) ovary OSS  (340) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (261) Schneider line 2 Sg4  (350) embryonic 1182-4H  (219) embryonic GM2  (254) embryonic Kc167  (322) embryonic S1  (335) embryonic S3  (341) leg disc CME L1  (247) wing disc CME-W2  (260) wing disc ML-DmD8  (274) wing disc ML-DmD9  (240) wing disc ML-DmD16-c3  (514) wing disc ML-DmD21  (474) wing disc ML-DmD32  (348) haltere disc ML-DmD17-c3  (446) eye-antennal disc ML-DmD11  (196) antennal disc ML-DmD20-c5  (255) mixed discs ML-DmD4-c1  (502) CNS ML-DmBG1-c1  (350) CNS ML-DmBG2-c2  (325) tumorous blood cells mbn2  (400) ovary fGS/OSS  (369) ovary OSC  (525) ovary OSS  (340) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    261 Schneider line 2 Sg4    350 embryonic 1182-4H    219 embryonic GM2    254 embryonic Kc167    322 embryonic S1    335 embryonic S3    341 leg disc CME L1    247 wing disc CME-W2    260 wing disc ML-DmD8    274 wing disc ML-DmD9    240 wing disc ML-DmD16-c3    514 wing disc ML-DmD21    474 wing disc ML-DmD32    348 haltere disc ML-DmD17-c3    446 eye-antennal disc ML-DmD11    196 antennal disc ML-DmD20-c5    255 mixed discs ML-DmD4-c1    502 CNS ML-DmBG1-c1    350 CNS ML-DmBG2-c2    325 tumorous blood cells mbn2    400 ovary fGS/OSS    369 ovary OSC    525 ovary OSS    340 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    261 Schneider line 2 Sg4    350 embryonic 1182-4H    219 embryonic GM2    254 embryonic Kc167    322 embryonic S1    335 embryonic S3    341 leg disc CME L1    247 wing disc CME-W2    260 wing disc ML-DmD8    274 wing disc ML-DmD9    240 wing disc ML-DmD16-c3    514 wing disc ML-DmD21    474 wing disc ML-DmD32    348 haltere disc ML-DmD17-c3    446 eye-antennal disc ML-DmD11    196 antennal disc ML-DmD20-c5    255 mixed discs ML-DmD4-c1    502 CNS ML-DmBG1-c1    350 CNS ML-DmBG2-c2    325 tumorous blood cells mbn2    400 ovary fGS/OSS    369 ovary OSC    525 ovary OSS    340 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (261) Schneider line 2 Sg4  (350) embryonic 1182-4H  (219) embryonic GM2  (254) embryonic Kc167  (322) embryonic S1  (335) embryonic S3  (341) leg disc CME L1  (247) wing disc CME-W2  (260) wing disc ML-DmD8  (274) wing disc ML-DmD9  (240) wing disc ML-DmD16-c3  (514) wing disc ML-DmD21  (474) wing disc ML-DmD32  (348) haltere disc ML-DmD17-c3  (446) eye-antennal disc ML-DmD11  (196) antennal disc ML-DmD20-c5  (255) mixed discs ML-DmD4-c1  (502) CNS ML-DmBG1-c1  (350) CNS ML-DmBG2-c2  (325) tumorous blood cells mbn2  (400) ovary fGS/OSS  (369) ovary OSC  (525) ovary OSS  (340) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (261) Schneider line 2 Sg4  (350) embryonic 1182-4H  (219) embryonic GM2  (254) embryonic Kc167  (322) embryonic S1  (335) embryonic S3  (341) leg disc CME L1  (247) wing disc CME-W2  (260) wing disc ML-DmD8  (274) wing disc ML-DmD9  (240) wing disc ML-DmD16-c3  (514) wing disc ML-DmD21  (474) wing disc ML-DmD32  (348) haltere disc ML-DmD17-c3  (446) eye-antennal disc ML-DmD11  (196) antennal disc ML-DmD20-c5  (255) mixed discs ML-DmD4-c1  (502) CNS ML-DmBG1-c1  (350) CNS ML-DmBG2-c2  (325) tumorous blood cells mbn2  (400) ovary fGS/OSS  (369) ovary OSC  (525) ovary OSS  (340) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    261 Schneider line 2 Sg4    350 embryonic 1182-4H    219 embryonic GM2    254 embryonic Kc167    322 embryonic S1    335 embryonic S3    341 leg disc CME L1    247 wing disc CME-W2    260 wing disc ML-DmD8    274 wing disc ML-DmD9    240 wing disc ML-DmD16-c3    514 wing disc ML-DmD21    474 wing disc ML-DmD32    348 haltere disc ML-DmD17-c3    446 eye-antennal disc ML-DmD11    196 antennal disc ML-DmD20-c5    255 mixed discs ML-DmD4-c1    502 CNS ML-DmBG1-c1    350 CNS ML-DmBG2-c2    325 tumorous blood cells mbn2    400 ovary fGS/OSS    369 ovary OSC    525 ovary OSS    340 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    209 cold shock, 4-day adult    143 heat shock, 4-day adult    152 Cadmium 50 mM 6 hrs, larvae L3    114 Cadmium 50 mM 12 hrs, larvae L3    190 Cadmium 50 mM 48 hrs, 4-day adult    188 Cadmium 100 mM 48 hrs, 4-day adult    313 Copper 0.5 mM 12 hrs, larvae L3    227 Copper 15 mM 48 hrs, 4-day adult    681 Zinc 5 mM 12 hrs, larvae L3    189 Zinc 4.5 mM 48 hrs, 4-day adult    317 Ethanol 2.5% 3 hrs, larvae L3    160 Ethanol 5% 3 hrs, larvae L3    140 Ethanol 10% 3 hrs, larvae L3    105 Caffeine 1.5 mg/ml 4 hrs, larvae L3    107 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    297 Caffeine 25 mg/ml 48 hrs, 4-day adult    250 Paraquat 5 mM 48 hrs, 4-day adult    207 Paraquat 10 mM 48 hrs, 4-day adult    155 Rotenone 2 μg 12 hrs, larvae L3    122 Rotenone 8 μg 12 hrs, larvae L3    87 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (209) cold shock, 4-day adult  (143) heat shock, 4-day adult  (152) Cadmium 50 mM 6 hrs, larvae L3  (114) Cadmium 50 mM 12 hrs, larvae L3  (190) Cadmium 50 mM 48 hrs, 4-day adult  (188) Cadmium 100 mM 48 hrs, 4-day adult  (313) Copper 0.5 mM 12 hrs, larvae L3  (227) Copper 15 mM 48 hrs, 4-day adult  (681) Zinc 5 mM 12 hrs, larvae L3  (189) Zinc 4.5 mM 48 hrs, 4-day adult  (317) Ethanol 2.5% 3 hrs, larvae L3  (160) Ethanol 5% 3 hrs, larvae L3  (140) Ethanol 10% 3 hrs, larvae L3  (105) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (107) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (297) Caffeine 25 mg/ml 48 hrs, 4-day adult  (250) Paraquat 5 mM 48 hrs, 4-day adult  (207) Paraquat 10 mM 48 hrs, 4-day adult  (155) Rotenone 2 μg 12 hrs, larvae L3  (122) Rotenone 8 μg 12 hrs, larvae L3  (87) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult  (209) cold shock, 4-day adult  (143) heat shock, 4-day adult  (152) Cadmium 50 mM 6 hrs, larvae L3  (114) Cadmium 50 mM 12 hrs, larvae L3  (190) Cadmium 50 mM 48 hrs, 4-day adult  (188) Cadmium 100 mM 48 hrs, 4-day adult  (313) Copper 0.5 mM 12 hrs, larvae L3  (227) Copper 15 mM 48 hrs, 4-day adult  (681) Zinc 5 mM 12 hrs, larvae L3  (189) Zinc 4.5 mM 48 hrs, 4-day adult  (317) Ethanol 2.5% 3 hrs, larvae L3  (160) Ethanol 5% 3 hrs, larvae L3  (140) Ethanol 10% 3 hrs, larvae L3  105 Caffeine 1.5 mg/ml 4 hrs, larvae L3  107 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (297) Caffeine 25 mg/ml 48 hrs, 4-day adult  (250) Paraquat 5 mM 48 hrs, 4-day adult  (207) Paraquat 10 mM 48 hrs, 4-day adult  (155) Rotenone 2 μg 12 hrs, larvae L3  (122) Rotenone 8 μg 12 hrs, larvae L3    87 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    209 cold shock, 4-day adult    143 heat shock, 4-day adult    152 Cadmium 50 mM 6 hrs, larvae L3    114 Cadmium 50 mM 12 hrs, larvae L3    190 Cadmium 50 mM 48 hrs, 4-day adult    188 Cadmium 100 mM 48 hrs, 4-day adult    313 Copper 0.5 mM 12 hrs, larvae L3    227 Copper 15 mM 48 hrs, 4-day adult    681 Zinc 5 mM 12 hrs, larvae L3    189 Zinc 4.5 mM 48 hrs, 4-day adult    317 Ethanol 2.5% 3 hrs, larvae L3    160 Ethanol 5% 3 hrs, larvae L3    140 Ethanol 10% 3 hrs, larvae L3    105 Caffeine 1.5 mg/ml 4 hrs, larvae L3    107 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    297 Caffeine 25 mg/ml 48 hrs, 4-day adult    250 Paraquat 5 mM 48 hrs, 4-day adult    207 Paraquat 10 mM 48 hrs, 4-day adult    155 Rotenone 2 μg 12 hrs, larvae L3    122 Rotenone 8 μg 12 hrs, larvae L3    87 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    209 cold shock, 4-day adult    143 heat shock, 4-day adult    152 Cadmium 50 mM 6 hrs, larvae L3    114 Cadmium 50 mM 12 hrs, larvae L3    190 Cadmium 50 mM 48 hrs, 4-day adult    188 Cadmium 100 mM 48 hrs, 4-day adult    313 Copper 0.5 mM 12 hrs, larvae L3    227 Copper 15 mM 48 hrs, 4-day adult    681 Zinc 5 mM 12 hrs, larvae L3    189 Zinc 4.5 mM 48 hrs, 4-day adult    317 Ethanol 2.5% 3 hrs, larvae L3    160 Ethanol 5% 3 hrs, larvae L3    140 Ethanol 10% 3 hrs, larvae L3    105 Caffeine 1.5 mg/ml 4 hrs, larvae L3    107 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    297 Caffeine 25 mg/ml 48 hrs, 4-day adult    250 Paraquat 5 mM 48 hrs, 4-day adult    207 Paraquat 10 mM 48 hrs, 4-day adult    155 Rotenone 2 μg 12 hrs, larvae L3    122 Rotenone 8 μg 12 hrs, larvae L3    87 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (209) cold shock, 4-day adult  (143) heat shock, 4-day adult  (152) Cadmium 50 mM 6 hrs, larvae L3  (114) Cadmium 50 mM 12 hrs, larvae L3  (190) Cadmium 50 mM 48 hrs, 4-day adult  (188) Cadmium 100 mM 48 hrs, 4-day adult  (313) Copper 0.5 mM 12 hrs, larvae L3  (227) Copper 15 mM 48 hrs, 4-day adult  (681) Zinc 5 mM 12 hrs, larvae L3  (189) Zinc 4.5 mM 48 hrs, 4-day adult  (317) Ethanol 2.5% 3 hrs, larvae L3  (160) Ethanol 5% 3 hrs, larvae L3  (140) Ethanol 10% 3 hrs, larvae L3  (105) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (107) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (297) Caffeine 25 mg/ml 48 hrs, 4-day adult  (250) Paraquat 5 mM 48 hrs, 4-day adult  (207) Paraquat 10 mM 48 hrs, 4-day adult  (155) Rotenone 2 μg 12 hrs, larvae L3  (122) Rotenone 8 μg 12 hrs, larvae L3  (87) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult  (209) cold shock, 4-day adult  143 heat shock, 4-day adult  (152) Cadmium 50 mM 6 hrs, larvae L3  114 Cadmium 50 mM 12 hrs, larvae L3  (190) Cadmium 50 mM 48 hrs, 4-day adult  (188) Cadmium 100 mM 48 hrs, 4-day adult  (313) Copper 0.5 mM 12 hrs, larvae L3  (227) Copper 15 mM 48 hrs, 4-day adult  (681) Zinc 5 mM 12 hrs, larvae L3  (189) Zinc 4.5 mM 48 hrs, 4-day adult  (317) Ethanol 2.5% 3 hrs, larvae L3  (160) Ethanol 5% 3 hrs, larvae L3  140 Ethanol 10% 3 hrs, larvae L3  105 Caffeine 1.5 mg/ml 4 hrs, larvae L3  107 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (297) Caffeine 25 mg/ml 48 hrs, 4-day adult  (250) Paraquat 5 mM 48 hrs, 4-day adult  (207) Paraquat 10 mM 48 hrs, 4-day adult  (155) Rotenone 2 μg 12 hrs, larvae L3  122 Rotenone 8 μg 12 hrs, larvae L3    87 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    209 cold shock, 4-day adult    143 heat shock, 4-day adult    152 Cadmium 50 mM 6 hrs, larvae L3    114 Cadmium 50 mM 12 hrs, larvae L3    190 Cadmium 50 mM 48 hrs, 4-day adult    188 Cadmium 100 mM 48 hrs, 4-day adult    313 Copper 0.5 mM 12 hrs, larvae L3    227 Copper 15 mM 48 hrs, 4-day adult    681 Zinc 5 mM 12 hrs, larvae L3    189 Zinc 4.5 mM 48 hrs, 4-day adult    317 Ethanol 2.5% 3 hrs, larvae L3    160 Ethanol 5% 3 hrs, larvae L3    140 Ethanol 10% 3 hrs, larvae L3    105 Caffeine 1.5 mg/ml 4 hrs, larvae L3    107 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    297 Caffeine 25 mg/ml 48 hrs, 4-day adult    250 Paraquat 5 mM 48 hrs, 4-day adult    207 Paraquat 10 mM 48 hrs, 4-day adult    155 Rotenone 2 μg 12 hrs, larvae L3    122 Rotenone 8 μg 12 hrs, larvae L3    87 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_30
External Data & Images
Linkouts	BDGP expression data • LD26077 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004177 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7109-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for mts Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | embryonic stage | recessive mts02496 mts05559 mtsk06009 mtsk09822 mtsk12502 mtsk16501 mtsXE-2202 mtsXE-2258 lethal | pupal stage, with Scer\GAL4pnr-MD237 mtsGD12133 lethal | pupal stage | recessive mts299 lethal | recessive mts02496 mts05559 mtss5286 mtsXE-2202 mtsXE-2258 viable mtsEY12638 Sterility Allele fertile mtsEY12638 Other Phenotypes Allele increased cell number, with Scer\GAL4Act.PU mtsdn181.Scer\UAS locomotor rhythm defective, with Scer\GAL4P2.4.Pdf mtsdn181.Scer\UAS mtsScer\UAS.cHa locomotor rhythm defective, with Scer\GAL4tim.PE mtsdn181.Scer\UAS mtsScer\UAS.cHa mitotic cell cycle defective mtsk09822 neuroanatomy defective, with Scer\GAL4elav.PLu mtsdn181.Scer\UAS neuroanatomy defective (with mts299) mtsXE-2258 neuroanatomy defective (with mtsXE-2258) mts299 neuroanatomy defective | larval stage mts299 mtsGD12133 neuroanatomy defective | larval stage, with Scer\GAL4ase.neuro mtsGD12133 neuroanatomy defective | larval stage (with mts299) mtss5286 neuroanatomy defective | larval stage (with mtss5286) mts299 neuroanatomy defective | somatic clone mts299 planar polarity defective, with Scer\GAL4ptc-559.1 mtsdn165.Scer\UAS mtsdn181.Scer\UAS mtsdn214.Scer\UAS visible, with Scer\GAL4GMR.PF mtsDN.Scer\UAS Phenotype manifest in Allele bouton & neuromuscular junction | larval stage, with Scer\GAL4elav.PLu mtsdn181.Scer\UAS embryonic/larval brain mtsGD12133 mts299 embryonic/larval brain, with Scer\GAL4ase.neuro mtsGD12133 embryonic/larval brain (with mts299) mtss5286 embryonic/larval brain (with mtss5286) mts299 embryonic/larval neuroblast, with Scer\GAL4Act.PU mtsdn181.Scer\UAS eye, with Scer\GAL4GMR.PF mtsDN.Scer\UAS microtubule & neuromuscular junction | larval stage, with Scer\GAL4elav.PLu mtsdn181.Scer\UAS neuroblast | supernumerary mtsGD12133 mts299 neuroblast | supernumerary, with Scer\GAL4ase.neuro mtsGD12133 neuroblast | supernumerary (with mts299) mtsXE-2258 mtss5286 neuroblast | supernumerary (with mtss5286) mts299 neuroblast | supernumerary (with mtsXE-2258) mts299 type II neuroblast | somatic clone | supernumerary mts299 wing hair, with Scer\GAL4ptc-559.1 mtsdn165.Scer\UAS mtsdn181.Scer\UAS mtsdn214.Scer\UAS wing hair | supernumerary, with Scer\GAL4ptc-559.1 mtsScer\UAS.cHa
Classical Alleles ( 18 )
For All Classical Alleles Show
Allele of mts Class Mutagen Stocks Known lesion mtsk12502 P-element activity 3 -- mtss5286 P-element activity 2 -- mts02496 P-element activity 1 Yes mtsc02035 piggyBac transposase 1 -- mtsEY12638 P-element activity 1 -- mtsk16501 P-element activity 1 -- mtsNP0662 1 -- mtsXE-2258 X ray 1 Yes mts05559 P-element activity 0 -- mts299 hypomorphic allele - genetic evidence 0 Yes mtsCPTI003684 piggyBac transposase 0 Yes mtsEP2405 P-element activity 0 -- mtsf04519 piggyBac transposase 0 -- mtsf05498 piggyBac transposase 0 -- mtsk06009 P-element activity 0 -- mtsk09822 P-element activity 0 Yes mtsunspecified 0 -- mtsXE-2202 X ray 0 Yes
Alleles Carried on Transgenic Constructs ( 12 )
For All Alleles Carried on Transgenic Constructs Show
Allele of mts Class Mutagen Stocks Known lesion mtsGD12133 in vitro construct - RNAi in vitro construct - regulatory fusion 3 Yes mtsHMS01804 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes mtsJF02805 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes mtsAct5C.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes mtsDN.Scer\UAS in vitro construct - site directed mutagenesis in vitro construct - regulatory fusion 0 Yes mtsdn165.Scer\UAS in vitro construct - regulatory fusion 0 Yes mtsdn181.Scer\UAS in vitro construct - regulatory fusion 0 Yes mtsdn214.Scer\UAS in vitro construct - regulatory fusion 0 Yes mtsdsRNA.1-690 in vitro construct - RNAi 0 Yes mtsScer\UAS.cHa in vitro construct - regulatory fusion 0 Yes mtsScer\UAS.cUa in vitro construct - regulatory fusion 0 Yes mtsScer\UAS.T:Hsap\MYC in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)28D-15 (Snaith et al., 1996) Df(2L)28D-19 (Snaith et al., 1996) Df(2L)28D-55 (Snaith et al., 1996) Df(2L)BSC41 (Deal et al., 2003.9.17, Casso et al., 2008) Df(2L)BSC142 (Christensen and Cook, 2006.3.8) Df(2L)BSC190 (Christensen and Cook, 2006.8.29) Df(2L)BSC191 (Christensen and Cook, 2006.8.29) Df(2L)BSC233 (Christensen and Cook, 2006.12.5) Df(2L)Dwee-δ5 (BDGP Project Members, 1994-1999) Df(2L)ED12527 (Ramel et al., 2007) Df(2L)Exel7032 (Ryder, 2004.4.26) Df(2L)XE-52 (Wassarman et al., 1996) Df(2L)XE-715 (Wassarman et al., 1996) Df(2L)XE-2267 (Wassarman et al., 1996) Df(2L)XE-2269 (Wassarman et al., 1996) Df(2L)XE-2387 (Wassarman et al., 1996) Df(2L)XE-2519 (Wassarman et al., 1996) Df(2L)XE-2668 (Wassarman et al., 1996) Df(2L)XE-2750 (Spradling et al., 1999, BDGP Project Members, 1994-1999, Wassarman et al., 1996) Df(2L)XE-2794 (Wassarman et al., 1996) Df(2L)XE-2860 (Wassarman et al., 1996) Df(2L)XE-3103 (Wassarman et al., 1996) Df(2L)XE-3494 (Wassarman et al., 1996) Df(2L)XE-3595 (Wassarman et al., 1996) Df(2L)XE-3696 (Wassarman et al., 1996) Df(2L)XE-3781 (Wassarman et al., 1996) Df(2L)XE-3801 (BDGP Project Members, 1994-1999, Wassarman et al., 1996, Casso et al., 2008) Df(2L)XE-3841 (Wassarman et al., 1996) Df(2R)Kr10 (BDGP Project Members, 1994-1999)
Not disrupted in	Df(2L)J-H (Spradling et al., 1999, BDGP Project Members, 1994-1999) Df(2L)spd (Spradling et al., 1999, BDGP Project Members, 1994-1999) Df(2L)Trf-C6R31 (BDGP Project Members, 1994-1999) Df(2R)M60E (BDGP Project Members, 1994-1999)
Partially disrupted in	Df(2L)RACK1-mts (Kadrmas et al., 2007)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD12133} NA P{TRiP.HMS01804} NA P{TRiP.JF02805} NA P{UAS-mts.dn165} NA P{UAS-mts.dn181} NA P{UAS-mts.dn214} NA P{UAS-mts.DN} NA P{UAS-mts.H} NA P{UAS-mts.U} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}l(2)SH0298SH0298 No P{lacW}mtsk06009 No P{lacW}mtsk09822 No P{lacW}mtsk12502 No P{lacW}mtsk16501 No P{lacW}mtss5286 No P{PZ}mts02496 No P{PZ}mts05559 No insertion of mobile activating element P{EP}mtsEP2405 NA P{EPgy2}mtsEY12638 NA miscellaneous insertions PBac{768.FSVS-0}mtsCPTI003684 NA PBac{PB}mtsc02035 NA PBac{WH}mtsf04519 NA PBac{WH}mtsf05498 NA insertion of enhancer trap binary system P{GawB}mtsNP0662 No
Gene Ontology: Function, Process & Cellular Component ( 27 unique terms )
Terms Based on Experimental Evidence ( 26 terms )
Molecular Function
CV term Evidence References
phosphatase regulator activity inferred from direct assay (Wang et al., 2008) protein serine/threonine phosphatase activity inferred from mutant phenotype (Snaith et al., 1996)
Biological Process
CV term Evidence References
actin filament organization inferred from mutant phenotype (Kiger et al., 2003) asymmetric neuroblast division inferred from genetic interaction with l(2)gl (Ogawa et al., 2009) inferred from genetic interaction with par-6 (Ogawa et al., 2009) canonical Wnt receptor signaling pathway inferred from mutant phenotype (Zhang et al., 2009) cell adhesion inferred from mutant phenotype (Kiger et al., 2003) centrosome cycle inferred from mutant phenotype (Chen et al., 2007) centrosome duplication inferred from mutant phenotype (Müller et al., 2010) centrosome organization inferred from mutant phenotype (Dobbelaere et al., 2008) chromosome segregation inferred from mutant phenotype (Chen et al., 2007) establishment of epithelial cell polarity inferred from expression pattern (Ogawa et al., 2009) microtubule cytoskeleton organization inferred from mutant phenotype (Viquez et al., 2006) mitosis inferred from mutant phenotype (Snaith et al., 1996) mitotic cell cycle inferred from mutant phenotype (Chen et al., 2007) negative regulation of neuroblast proliferation inferred from mutant phenotype (Wang et al., 2009) oogenesis inferred from mutant phenotype (Wassarman et al., 1996) phagocytosis, engulfment inferred from mutant phenotype (Stroschein-Stevenson et al., 2006) positive regulation of smoothened signaling pathway inferred from genetic interaction with hh (Casso et al., 2008) inferred from genetic interaction with smo (Casso et al., 2008) protein dephosphorylation inferred from mutant phenotype (Snaith et al., 1996) R7 cell fate commitment inferred from genetic interaction with Ras85D (Wassarman et al., 1996) regulation of cell shape inferred from mutant phenotype (Kiger et al., 2003) response to light stimulus inferred from genetic interaction with inaC (Wang et al., 2008) spindle assembly inferred from mutant phenotype (Chen et al., 2007) spindle organization inferred from mutant phenotype (Snaith et al., 1996)
Cellular Component
CV term Evidence References
centriole inferred from direct assay (Dobbelaere et al., 2008) cytoplasm inferred from direct assay (Chabu and Doe, 2009, Mayer-Jaekel et al., 1994, Dobbelaere et al., 2008)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
protein serine/threonine phosphatase activity inferred from sequence or structural similarity (Mayer-Jaekel et al., 1992) non-traceable author statement (Swiss-Prot Project Members, 1991.11.1, Morrison et al., 2000)
Biological Process
CV term Evidence References
protein dephosphorylation non-traceable author statement (Morrison et al., 2000, Swiss-Prot Project Members, 1991.11.1)
Cellular Component
CV term Evidence References
protein phosphatase type 2A complex inferred from sequence or structural similarity (Mayer-Jaekel et al., 1992)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
mts - A16 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - AR-2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - ATPsyn-γ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Aats-asn anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Aats-phe anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) mts - Arf79F anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Arp1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Arpc4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Art2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Ate1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Atg4 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) mts - Atx2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG10077 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG10175 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG1024 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG10566 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG10585 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG10660 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG10673 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG10681 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG10949 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG10958 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG1105 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG11504 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) mts - CG11550 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG11655 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG11679 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG11815 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG12123 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG12129 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG12264 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG12344 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG1265 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG12659 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG13567 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG14141 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG1416 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG14195 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG14262 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG14500 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG14556 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG14818 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG14826 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG15118 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG15643 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG15784 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG1607 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG1637 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG16815 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG17029 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG17242 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG17273 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG17544 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG17601 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG1774 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG18284 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG18480 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG18769 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG1943 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG2010 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG2065 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG2211 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG2812 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG2921 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG30059 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG30338 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG3036 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG3085 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG3091 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG31522 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG31523 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG31637 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG31675 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG31910 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG3209 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG3224 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG3225 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG32295 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG32698 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG3303 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG33514 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG3409 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG3492 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG3509 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG3530 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG3544 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG3568 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG3618 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG3689 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG3793 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG42724 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG43795 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG43897 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG4407 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) mts - CG4415 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG4502 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG4612 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG4617 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG4619 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG4766 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG4854 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG4901 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG4973 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG4998 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG5162 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG5255 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG5482 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG5525 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG5565 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG5776 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG5823 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG5828 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG5961 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG6073 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG6178 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG6337 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG6470 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG6638 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG6701 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG6712 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG6927 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG6937 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG7033 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG7206 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG7339 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG7429 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG7609 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG7646 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG7878 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG8004 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG8026 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG8173 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG8311 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG8745 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG8765 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG8814 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG8888 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG8993 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG9005 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG9062 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG9596 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG9775 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG9890 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG9920 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG9947 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CG9967 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CR18854 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CanB anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CanB2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Cct2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - CkIIα anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Cka anti tag coimmunoprecipitation, peptide massfingerprinting (Ribeiro et al., 2010) mts - Cyp28c1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Cyp6a13 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Cyp6a22 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Cyp6d4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Cyt-c-d anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Dcp-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Diedel anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Dim1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - DnaJ-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Dp1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Drip anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Eb1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Eig71Ed anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Eip71CD anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Ets96B anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Fatp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Fer1HCH anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Flo-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Gale anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Gmd anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Gs1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Gαo anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Gγ1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Hmgs experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) mts - Hph anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Hsc70-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Hsp22 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Hsp23 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Hsp27 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Hsp68 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Hsp70Aa anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Hsp70Ba anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Iap2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - ImpL2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Ipk1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Klp61F anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - LBR anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Liprin-α anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Lst8 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) mts - MED27 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - MESK2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - MFS16 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - MRG15 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) mts - Map205 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Max anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Mcm3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Mcm5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Mcm7 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Mec2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Mnn1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Mob4 anti tag coimmunoprecipitation, peptide massfingerprinting (Ribeiro et al., 2010) mts - NHP2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Nmdar1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Nmt anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Obp19c anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Ocrl anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Orc4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - PSR anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) mts - Pex16 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - PhKγ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Pi4KIIα anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Pk17E anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Pp2A-29B anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) mts - Prat anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Prosα4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Prosβ1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Prosβ6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Prp31 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Pten anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Pvf1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Rab11 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Rab18 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Rab6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Rac1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Rac2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - RagC-D anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Ran anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - RasGAP1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Rassf anti tag coimmunoprecipitation, peptide massfingerprinting (Ribeiro et al., 2010) mts - Rbp1-like anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Rcd6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Rheb anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - RluA-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - RnrS anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - RpL35A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - RpS19a anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - RpS21 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Rpt1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Rpt6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Rsf1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - SC35 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - SNCF anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - SPE anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) mts - Sdc anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Sk1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Sk2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Skp2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - SmD3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Smox anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Socs44A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Sry-δ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Su(var)2-10 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Syp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Tap42 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) mts - Tcp-1ζ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Tcp-1η anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Tsp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Ubx anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Uch-L5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Ucp4B anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Upf1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Uvrag anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Vap-33-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Vha55 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Vps4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Vsx2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - Zn72D anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - aph-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - atms anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - awd anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - brn anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - cathD anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - dac anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - dimm anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - dock anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - eIF4AIII anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - eIF4E-4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - eIF4E-6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - exu anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - fd59A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - fend anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - flw anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - frc anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - fu12 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - fzy anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - gk anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - grk anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - grp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - gus anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - hpo anti tag coimmunoprecipitation, peptide massfingerprinting (Ribeiro et al., 2010) mts - hyd anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - igl anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) mts - ihog anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - inaC anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - ine anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - kuk anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - l(2)03709 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - l(3)02640 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - lkb1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - mRpL47 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - mRpL48 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - mTerf5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - mdy anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - mei-S332 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - mib1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - msl-3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - nito anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - noi anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - nwk anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) mts - ovo anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - p38b anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - papi anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - pdm3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - pgant8 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - poly anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - ptr anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - r anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - ref(2)P anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - roq anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - shf anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - shtd anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - sina anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - spn-A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - ste24a anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - tan experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) mts - tara anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - term anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - tkv anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - tor anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - ttm50 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - twi anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - tws anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - wdb anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) mts - wds anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - zpg anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - γTub37C anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - εCOP anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) mts - θTry anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions mts allele Gene References mtsk09822 png (Lee et al., 2001) mtss5286 png (Lee et al., 2001) mtsXE-2202 Dsor1 (Karim et al., 1996) phl (Karim et al., 1996) phl::tor (Karim et al., 1996) Ras85D (Wassarman et al., 1996, Karim et al., 1996) wdb (Hannus et al., 2002) mtsXE-2258 Dsor1 (Karim et al., 1996) phl (Wassarman et al., 1996, Karim et al., 1996) phl::tor (Wassarman et al., 1996, Karim et al., 1996) Ras85D (Wassarman et al., 1996, Karim et al., 1996) wdb (Hannus et al., 2002)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 70018 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0004177 DroID - A comprehensive database of gene and protein interactions. • FBgn0004177 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 45959 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • P23696
Orthologs
OrthoDB Orthologs (63) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6Z370S Dipteran inclusive ortholog search EOG6H9XV8 Insect inclusive ortholog search EOG6ZGN81 Arthropod inclusive ortholog search EOG6FQZ79 Metazoa inclusive ortholog search EOG676XT0
Orthologs in Drosophila Species (EOG6Z370S)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\mts     Drosophila simulans   Dsim\GD23492 Y   Drosophila sechellia   Dsec\GM16609 Y   Drosophila erecta   Dere\GG10501 Y   Drosophila yakuba   Dyak\GE14639 Y   Drosophila ananassae   Dana\GF21831 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA25737 Y   Drosophila persimilis   Dper\GL18646 Y   Drosophila willistoni   Dwil\GK23721 Y   Drosophila virilis   Dvir\GJ17232 Y   Drosophila mojavensis   Dmoj\GI14963 Y   Drosophila grimshawi   Dgri\GH10208 Y
Orthologs in non-Drosophila Dipterans (EOG6H9XV8)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL013068   Anopheles gambiae Malaria mosquito  Agam\AGAP010172   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ013232
Orthologs in non-Dipteran Insects (EOG6ZGN81)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\mts   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG008036   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH24142   Camponotus floridanus Florida carpenter ant  Cflo\CFLO15171   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL13182   Linepithema humile Argentine ant  Lhum\LH13436   Pogonomyrmex barbatus Red harvester ant  Pbar\PB17228   Solenopsis invicta Red fire ant  Sinv\SINV11123   Acyrthosiphon pisum Pea aphid  Apim\ACYPI000060   Bombyx mori Silkmoth  Bmor\BGIBMGA007460   Pediculus humanus Human body louse  Phum\PHUM269020   Tribolium castaneum Red flour beetle  Tcas\TC005366
Orthologs in non-Insect Arthropods (EOG6FQZ79)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\Aen Y Daphnia pulex Water flea  Dpux\cox2 Y Daphnia pulex Water flea  Dpux\Appbp2 Y Daphnia pulex Water flea  Dpux\JGI_V11_72831 Y Ixodes scapularis Deer tick  Isca\ISCW014549 Y Ixodes scapularis Deer tick  Isca\ISCW015013 Y
Orthologs in non-Arthropod Metazoa (EOG676XT0)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\pph-4.1 Y Caenorhabditis elegans Nematode  Cele\pph-4.2 Y Caenorhabditis elegans Nematode  Cele\let-92 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_025182gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_027953gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_011983gn Y Danio rerio Zebrafish  Drer\zgc:56064 Y Danio rerio Zebrafish  Drer\ppp4cb Y Danio rerio Zebrafish  Drer\ppp2ca Y Danio rerio Zebrafish  Drer\ppp6c Y Danio rerio Zebrafish  Drer\ppp4ca Y Danio rerio Zebrafish  Drer\ppp2cb Y Xenopus tropicalis Western clawed frog  Xtro\ppp2cb Y Xenopus tropicalis Western clawed frog  Xtro\ppp2ca Y Xenopus tropicalis Western clawed frog  Xtro\ppp4c Y Xenopus tropicalis Western clawed frog  Xtro\ppp6c Y Gallus gallus Domestic chicken  Ggal\PPP2CA Y Gallus gallus Domestic chicken  Ggal\PPP6C Y Gallus gallus Domestic chicken  Ggal\PPP2CA Y Mus musculus House mouse  Mmus\Ppp2cb Y Mus musculus House mouse  Mmus\Ppp6c Y Mus musculus House mouse  Mmus\Ppp4c Y Mus musculus House mouse  Mmus\Ppp2ca Y Rattus norvegicus Norway rat  Rnor\Ppp4c Y Rattus norvegicus Norway rat  Rnor\Ppp6c Y Rattus norvegicus Norway rat  Rnor\Ppp2cb Y Rattus norvegicus Norway rat  Rnor\Ppp2ca Y Homo sapiens Human  Hsap\PPP6C Y Homo sapiens Human  Hsap\ENSG00000104695 Y Homo sapiens Human  Hsap\PPP2CA Y
Human Orthologs (3)
Gene OMIM HGNC Hsap\PPP6C     Hsap\ENSG00000104695     Hsap\PPP2CA
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD23492 Drosophila sechellia Dsec\GM16609 Drosophila erecta Dere\GG10501 Drosophila yakuba Dyak\GE14639 Drosophila ananassae Dana\GF21831 Drosophila pseudoobscura pseudoobscura Dpse\GA25737 Drosophila persimilis Dper\GL18646 Drosophila willistoni Dwil\GK23721 Drosophila virilis Dvir\GJ17232 Drosophila mojavensis Dmoj\GI14963 Drosophila grimshawi Dgri\GH10208
Stocks & Reagents
Stocks Listed in FlyBase ( 16 )
Bloomington	5684 mtsXE-2258/CyO, P{sevRas1.V12}FK1 10464 w67c23; P{lacW}mtss5286/CyO 27723 y1 v1; P{TRiP.JF02805}attP2 38337 y1 v1; P{TRiP.HMS01804}attP2 11193 P{PZ}mts02496 cn1/CyO; ry506 20763 y1 w67c23; P{EPgy2}mtsEY12638
Harvard	- PBac{PB}mtsc02035
Kyoto	103701 w*; P{GawB}mtsNP0662 / CyO 102837 y1 w67c23 ; P{lacW}mtsk12502 / CyO
VDRC	v35171 w1118; P{GD12133}v35171 v35172 w1118; P{GD12133}v35172 v41924 w1118; P{GD12133}v41924/CyO
	More stocks available...
Genomic Clones ( 3 )
	BACR09A04 BACR16J09 BACR31D05 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 178 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD26077
Other clones	DPiM_LD26077
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH07034 GH11886 GH12349 GH12361 GH24983 GH28822 GM01183 GM02581 GM07579 GM22437 LD04712 LD07316 LD08031 LD09226 LD12341 LD12727 LD13145 LD24587 LD24683 LD24970 LD26646 LD27606 LD30507 LD30519 LD31008 LD34788 LD41242 LD41631 LD47134 LD47839 LP01664 LP01952 LP02530 LP02594 LP08486 LP09023 LP11011 LP11560 LP13264 LP22129 LP23555 RE05537 RE34414 RE40081 RE41832 RE43407 RE44092 RE48751 RE49462 RE50651 RE51362 RE55331 RE63293 RE63815 RE64364 RE66388 RE68068 RE74822 RH04370 RH05878 RH06586 RH10831 RH11858 RH12036 RH14939 RH42286 RH56012 RH56449 RH67948 RH70904 SD01871 SD19732 SD23627 SD25410
Other clones	1364 17393 29319 30016 31405 35012 38939 41552 42320 43798 44915 64864 67578 70855 81925 119375 147820 147852 164513 164727 165349 167328 181643 191335 240959 273563 275369 283448 287728 295208 296538 522309 528094 bs75d07 CK01.40C.C8 CK01.113D.F3 CK01.123B.F8 CK01.142D.F12 Dmel_dig_009038_0689_2659 Dmel_dig_012846_0638_3188 Dmel_dig_016727_0600_0980 Dmel_dig_017599_0626_3311 Dmel_dig_019557_0685_0616 Dmel_neb_010306_0885_1925 Dmel_neb_012627_0671_3238 Dmel_neb_013442_0169_0475 Dmel_neb_014899_0827_2082 Dmel_neb_015006_0184_3159 EC28525 EC051561 EC055097 EC256621 EK054223 EK062303 EK093856 EK115956 EK122347 EK129751 EK137332 EK140244 EK152140 EK154519 EK157019 EK160953 EK162804 EK163330 EK166108 EK173013 EK176525 EK191454 EK196637 EK198639 EK204836 EK209303 EK215419 EK238915 EK253437 EK253461 EK268934 EK286454 EK294149 EK303262 EK304504 EK308826 EN00618 EN01812 EN02460 EN07928 EN08524 EN09931 EP08932 ESG012b.E21.2_F07 ESG018d.E21_F03 ESG019c.E21_D06 ESG0113d.B21_H08 FGH104E06 FGM004G02 FGM208A12 FGM237B10 FGM238E05 IP15962 RE01616
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0004177 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 45959
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: mts CG7109 (Bayraktaroglu, 2000.4.13)
Additional comments
Other Comments
	mts is required for efficient recruitment of pericentriolar material. (Dobbelaere et al., 2008) dsRNA directed against this gene has been used in a screen for genes required for constitutive protein secretion. (Bard et al., 2006) S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells. (Stroschein-Stevenson et al., 2006) Identified as a potential component of the hh signalling pathway in a genome-wide RNAi screen. dsRNA made from templates generated with primers directed affects the extent of expression of a hh signaling reporter construct in Clone 8 cells. (Nybakken et al., 2005) RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in Kc167 cells: change from round to spindle-shaped, with the formation of F-actin puncta and microtubule extensions. Alterations of cell shape are also evident in S2R+ cells; cells become round and detached. (Kiger et al., 2003) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) Identification: Enhancer trap expression pattern survey for loci expressed in the ring gland. (Harvie et al., 1998) Lack of mts causes a block in mitosis and uncouples the centrosome cycle from the nuclear cycle and prevents the attachment of microtubules to the kinetochore. (Snaith et al., 1996) Encodes the catalytic subunit of PP2A. (Wassarman et al., 1996) The mts product positively and negatively regulates Ras85D-mediated photoreceptor development. (Wassarman et al., 1996) A screen to identify mutations affecting the Ras85D signalling pathway identified alleles of phl, Dsor1, rl, aop, βggt-I, mts, ksr and phyl. (Therrien et al., 1995) mts has been molecularly cloned and developmental expression patterns examined. (Mayer-Jaekel et al., 1992) A mts cDNA has been cloned and sequenced. (Orgad et al., 1990)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057457 RefSeq (Proteins) • NP_476805 DDBJ / EMBL / GenBank • AA438543 AA942060 AAF52567 AAL13800 AC004723 AC008328 AQ073559 AW942828 AY058571 CAA38984 CAA55315 CL868585 CZ467633 CZ487054 CZ488088 CZ488089 G01458 X55199 X78577 Entrez Gene - A searchable database of RefSeq genes. • 45959 UniProtKB/Swiss-Prot • P23696
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Metallophosphoesterase domain (IPR004843) Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase (IPR006186) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD26077
Linkouts
	BioGRID - A database of protein and genetic interactions • 70018 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0004177 DroID - A comprehensive database of gene and protein interactions. • FBgn0004177 DRSC - Results from RNAi screens. • FBgn0004177 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004177 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7109-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0004177 FlyReactome - A curated knowledgebase of Drosophila melanogaster pathways • 97568 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 45959 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 45959 modMine - Data generated by the modENCODE project. • FBgn0004177 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • P23696
Synonyms & Secondary IDs ( 30 )
Reported As
Symbol Synonym	5559 (Harvie et al., 1998) CG7109 (Wang et al., 2009, Coulier et al., 2000, Morrison et al., 2000, Nybakken et al., 2005, Dobbelaere et al., 2008, Jia et al., 2009, Perkins et al., 2009, Cammarato et al., 2011, Wheeler et al., 2004, Bánréti et al., 2012, Ni et al., 2010.12.1) DmPp2A-28D (Cohen, 2005) dPP2A (Berry and Gehring, 1999, Merrow, 2006) dPP2A-C (Bielinski and Mumby, 2007) ER2-6 (Chang et al., 1994, ) l(2)02496   l(2)s5286   mts (Casso et al., 2008, Wang et al., 2009, Casso et al., 2007, Christensen and Cook, 2006.12.5, Christensen and Cook, 2006.8.29, Ramel et al., 2007, Christensen and Cook, 2006.8.29, Christensen and Cook, 2006.8.29, Wang et al., 2008, Stroschein-Stevenson et al., 2006, Stuart et al., 2007, Chen et al., 2007, Kadrmas et al., 2007, Nybakken et al., 2005, Kunttas-Tatli et al., 2009, Casso et al., 2008, Kunttas et al., 2008, Krahn et al., 2009, Su et al., 2011, Viquez et al., 2006, Dobbelaere et al., 2008, Stofanko et al., 2008, Jia et al., 2009, Moazzen et al., 2009, Zhang et al., 2009, Ogawa et al., 2009, Viquez et al., 2009, Chen et al., 2008, Salzer et al., 2010, Ribeiro et al., 2010, Maher et al., 2011, Kotadia et al., 2008, Chang et al., 2010, Wang et al., 2011, Chen et al., 2007, Wheeler et al., 2004, Bielinski and Mumby, 2007, Bánréti et al., 2012, Abruzzi et al., 2011, Ouyang et al., 2011, Wang et al., 2012) Mts (Krahn et al., 2009, Nam et al., 2007, Chabu and Doe, 2009, Viquez et al., 2006, Bandyopadhyay et al., 2006, Brownlee et al., 2011) MTS/PP2A (Morrison et al., 2000, Friedman and Perrimon, 2006) PP2 (Biswas et al., 2006, Cohen, 1994.4.1) PP2a (Hardin, 2005, Jenny et al., 2008) PP2A (Kyriacou and Odell, 2004, Lu et al., 2003, Bennett et al., 2003, Bennett et al., 1999, Millward et al., 1999, Helps et al., 1998, Hermon et al., 1998, Karim et al., 1997, Snaith et al., 1996, Karim et al., 1996, Chang et al., 1994, Chang et al., 1994, Orgad et al., 1990, Dombradi et al., 1990, Kunttas et al., 2007, Nam et al., 2007, Fang et al., 2007, Bose et al., 2008, Nogueira et al., 2008, Su et al., 2008, Choi et al., 2007, Krahn et al., 2009, Lu et al., 2009, Serio et al., 2010, Ouyang et al., 2011, Wang et al., 2012) Pp2A (Therrien et al., 1995, ) PP2a 28D (Lee et al., 2001) PP2A 28D (Cohen, 1997, Chen et al., 1992) Pp2A-28D (Guo et al., 1996, ) PP2AC (Janssens and Goris, 2001) PP2AC (Kotadia et al., 2008) PP2A-C (Wang et al., 2009, Matsubayashi et al., 2004) PP2Ac (Cygnar et al., 2005, Yanagawa et al., 2000) PP2A C (Su et al., 2011, Li et al., 2002)
Name Synonym	catalytic subunit C of type 2A protein phosphatase (Shiomi et al., 1994) microtubule star (Casso et al., 2008, Kadrmas et al., 2007, Kunttas-Tatli et al., 2009, Casso et al., 2008, Stofanko et al., 2008, Moazzen et al., 2009, Viquez et al., 2006, Ogawa et al., 2009, Wang et al., 2008, Viquez et al., 2009, Salzer et al., 2010, Ribeiro et al., 2010, Kotadia et al., 2008, Cammarato et al., 2011, Wang et al., 2011, Bánréti et al., 2012) Microtubule star (Manh et al., 2005, Chabu and Doe, 2009, Nie et al., 2009, Wang et al., 2004) phosphatase 2A catalytic subunit (Orgad, 1993.2.24) PP2A catalytic subunit (Jia et al., 2009, Nie et al., 2009, Viquez et al., 2009) protein phosphatase 2A (Bose et al., 2008, Choi et al., 2007) Protein phosphatase 2A at 28D
Secondary FlyBase IDs
	FBgn0010514 FBgn0010703 FBgn0031953
References ( 146 )
Generate a list of	All references relating to this gene ( 146 )
List References by type	Research paper  ( 82 ) Supplementary material  ( 8 ) Review  ( 10 ) Personal communication to FlyBase  ( 20 ) Abstract  ( 16 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 2 ) Letter  ( 1 ) Protein sequence record  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 11 )
	Bánréti et al., 2012, Autophagy 8(4): 623--636 PP2A regulates autophagy in two alternative ways in Drosophila. [FBrf0219207] Wang et al., 2012, PLoS ONE 7(6): e38569 Essential Roles of the Tap42-Regulated Protein Phosphatase 2A (PP2A) Family in Wing Imaginal Disc Development of Drosophila melanogaster. [FBrf0218627] Abruzzi et al., 2011, Genes Dev. 25(22): 2374--2386 Drosophila CLOCK target gene characterization: implications for circadian tissue-specific gene expression. [FBrf0216798] Booker et al., 2011, BMC Genomics 12: 50 False negative rates in Drosophila cell-based RNAi screens: a case study. [FBrf0212969] Brownlee et al., 2011, J. Cell Biol. 195(2): 231--243 The Protein Phosphatase 2A regulatory subunit Twins stabilizes Plk4 to induce centriole amplification. [FBrf0217352] Horn et al., 2011, Nat. Methods 8(4): 341--346 Mapping of signaling networks through synthetic genetic interaction analysis by RNAi. [FBrf0213352] Maher et al., 2011, Hum. Mol. Genet. 20(2): 261--270 ERK activation by the polyphenols fisetin and resveratrol provides neuroprotection in multiple models of Huntington's disease. [FBrf0212618] Ouyang et al., 2011, Development 138(11): 2185--2196 Dronc caspase exerts a non-apoptotic function to restrain phospho-Numb-induced ectopic neuroblast formation in Drosophila. [FBrf0213702] Rangone et al., 2011, PLoS Genet. 7(8): e1002225 Suppression of Scant Identifies Endos as a Substrate of Greatwall Kinase and a Negative Regulator of Protein Phosphatase 2A in Mitosis. [FBrf0214749] Su et al., 2011, Sci. Signal. 4(180): ra43 Sequential phosphorylation of smoothened transduces graded hedgehog signaling. [FBrf0216577] Wang et al., 2011, PLoS Genet. 7(8): e1002227 PP2A-Twins Is Antagonized by Greatwall and Collaborates with Polo for Cell Cycle Progression and Centrosome Attachment to Nuclei in Drosophila Embryos. [FBrf0214683] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...