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Gene Dmel\Ser

General Information
Symbol	Dmel\Ser	Species	D. melanogaster
Name	Serrate	Annotation symbol	CG6127
Feature type	protein_coding_gene	FlyBase ID	FBgn0004197
Gene Model Status	Current	Stock availability	6218 publicly available
Also Known As	Bd
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	97E6-97E8	Sequence location	3R:22,997,818..23,019,716 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Serrate is referred to in FlyBase by the symbol Dmel\Ser (CG6127, FBgn0004197). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: Notch binding; protein binding. There is experimental evidence for 14 unique biological process terms, many of which group under: single-organism developmental process; biological regulation; system development; cellular process; gland morphogenesis; post-embryonic organ morphogenesis; sensory organ development; immune system process; salivary gland morphogenesis; cell fate commitment. 82 alleles are reported. The phenotypes of these alleles are annotated with: adult segment; organ system subdivision; organ system; external compound sense organ; cephalopharyngeal skeleton; imaginal precursor; appendage segment; cell part; spiracle; integumentary specialisation. It has one annotated transcript and one annotated polypeptide. Protein features are: Delta/Serrate/lag-2 (DSL) protein; EGF-like calcium-binding; EGF-like calcium-binding, conserved site; EGF-like, conserved site; EGF-type aspartate/asparagine hydroxylation site; Epidermal growth factor-like domain; Jagged/Serrate protein; Notch ligand, N-terminal; VWC out. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of extremely low expression. Peak expression observed within 06-18 hour embryonic stages, at stages throughout the pupal period. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult hindgut, larval trachea. Comments on Affy2 ProbeSet: ProbeSet 1634766_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Ser. Gene sequence location is 3R:22997818..23019716.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	Bd: Beaded Bd: Beaded From Bridges and Morgan, 1923, Carnegie Inst. Washington Publ. No. 327: 152. Originally recovered alleles were recessive lethal with a dominant incised-wing phenotype; Bd1 was very weak and highly variable when first recovered, but gained expressivity with selection; subsequently isolated alleles were stronger. Wings reduced by marginal excision both anteriorly and posteriorly. Phenotype of Bd1/Bd1/+ extreme (Peter Lewis). Expression and interaction studied by Goldschmidt and Gardner [1942, Univ. Calif. (Berkeley) Publ. Zool. 49: 103-24]. Expression of Bd1, Bd3, and BdS suppressed by H (DIS 9) and Ax alleles (Bang). In combination with several different Minutes, causes incomplete development of anal and genital imaginal discs in males and less frequently in females (Goldschmidt, 1948, Proc. Nat. Acad. Sci. USA 34: 245-52; Sturtevant, 1949, Proc. Nat. Acad. Sci. USA 35: 311-13). BdS (originally designated Ser: Serrate) homozygous viable; initially thought to be homozygous lethal, but lethality removable by recombination (Belt, 1971, DIS 46: 116). The closely linked recessive lethal persists in many BdS-bearing chromosomes. Recessive lethal alleles, which lack the dominant wing phenotype, recovered as revertants of BdS (symbolized BdSrv) or selected on the basis of their failure to complement the lethality of Bd3 (symbolized Bdr). Allelism of Bdr1 (originally designated std: serratoid) inferred from enhanced wing incising in heterozygotes with BdS and genetic map position similar to that of BdS; homozygous viability unknown. Cuticle preparations of embryos homozygous for BdS revertants reveal lack of germband retraction, improper deposition of cuticle, lack of head and thoracic structures, lack of Filzkorper, and in severe cases, only a remaining patch of cuticle (either ventral or dorsal). Central-nervous-system defects revealed by anti-horseradish peroxidase preparations include breaks in the longitudinal and/or commissure nerve tracts, twisted or unretracted nerve tracts, only a single nerve tract, and occasionally only the presence of groups of staining cells scattered throughout the embryo (Fleming, et al.). Each BdSrv allele displays the whole range of embryonic phenotypes but the proportions of individuals with a particular phenotype varies between alleles. BdS: Beaded-Serrate BdS: Beaded-Serrate Edith M. Wallace, unpublished. Wings of BdS/+ and BdS/Df(3R)Ser notched at tip; deepest notch at second posterior cell. In triploids, one dose of BdS overlaps wild type. BdS is homozygous viable; initially thought to be homozygous lethal, but lethality removable by recombination (Belt, 1971, DIS 46: 116); the closely linked recessive lethal persists in many BdS-bearing chromosomes. Homozygous BdS produces extreme incision of wing margins especially in second posterior cell (Belt, 1971). As with other Bd alleles expression suppressed by H and Ax (Bang).
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
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Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 97E6-97E8   Limits computationally determined from genome sequence between P{PZ}sda03884 and P{PZ}btzrL203
Experimentally Determined Cytological Location
Cytogenetic map Notes References 97F-97F   (determined by in situ hybridisation)   (Thomas et al., 1991) 97F1-97F2   (determined by in situ hybridisation)   (Fleming et al., 1990)
Experimentally Determined Recombination Data
Location	3-92.5 (Duncan and Kaufman, 1975) 3-93.8 (Goldschmidt, 1944)
Left of (cM)	ca (Curry, 1939)
Right of (cM)	ro Pr (Curry, 1939)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Ser for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	DGC clone RE42104 appears problematic: incomplete CDS
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Ser-RA FBtr0085128  NM_079803   5552   1407
Additional Transcript Data & Comments
Reported size (kB)	5.9, 5.6, 5.2, 4.5, 2.5 (northern blot) (Thomas et al., 1991) 5.6, 5.5, 3.4 (northern blot) (Fleming et al., 1990)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Ser-PA   FBpp0084498   150.8   1407   7.11     NP_524527   AAF56678
Additional Polypeptide Data & Comments
Reported size (kDa)	1408 (aa); 150 (kD) (Thomas et al., 1991) 1404 (aa) (Fleming et al., 1990)
Comments	If the first AUG is used, the protein is 1443aa. The second AUG has a better match to the Cavener consensus. (Fleming et al., 1990)
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • EGF-like calcium-binding, conserved site (IPR018097) EGF-type aspartate/asparagine hydroxylation site (IPR000152) Epidermal growth factor-like domain (IPR000742) Delta/Serrate/lag-2 (DSL) protein (IPR001774) EGF-like calcium-binding (IPR001881) VWC out (IPR006552) Notch ligand, N-terminal (IPR011651) EGF-like, conserved site (IPR013032) Jagged/Serrate protein (IPR026219)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014297 AAF56678   AX357041 CAD23269   AX417399 CAD35403   AY128478 AAM75071   AY863907   AY863908   AY863909   AY863910   AY863911   AY863912   AY863913   AY863914   AY863915   AY863916   AY863917   AY863918   AY863919   AY863920   AY863921   AY863922   AY863923   AY863924   AY863925   AY863926   AY863927   AY863928   BI356067   BI358014   BI616589   BI641263   CK657759   CO187665   CO189674   CO190872   CO302846   CO344041   CO344474   EC051937   EC052386   EC052908   EC052912   EC053473   EC053954   EC054962   EC055331   EC080790   EC085842   EC207029   EC214099   EC234939   EC238770   EC253857   EC259619   GH949923   GH950960   GH951268   GH956339   GH965632   GH969097   M35759 AAA28938   S77925   X56811
UniProtKB/Swiss-Prot	P18168
UniProtKB/TrEMBL	Q8MQN5
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References protein binding site FBsf0000160856 3R:22,997,795..22,997,802 bound_moiety=ap-XP evidence=experimental (Yan et al., 2004, Bergman et al., 2005) protein binding site FBsf0000160857 3R:22,997,264..22,997,285 bound_moiety=pan-XP evidence=experimental (Yan et al., 2004, Bergman et al., 2005) protein binding site FBsf0000160858 3R:22,997,763..22,997,770 bound_moiety=ap-XP evidence=experimental (Yan et al., 2004, Bergman et al., 2005) protein binding site FBsf0000160859 3R:22,997,565..22,997,573 bound_moiety=Su(H)-XP evidence=experimental (Bergman et al., 2005, Yan et al., 2004) protein binding site FBsf0000160860 3R:22,997,731..22,997,743 bound_moiety=ap-XP evidence=experimental (Yan et al., 2004, Bergman et al., 2005) protein binding site FBsf0000160861 3R:22,997,027..22,997,034 bound_moiety=ap-XP evidence=experimental (Bergman et al., 2005, Yan et al., 2004) protein binding site FBsf0000160862 3R:22,997,214..22,997,223 bound_moiety=ap-XP evidence=experimental (Yan et al., 2004, Bergman et al., 2005) protein binding site FBsf0000160863 3R:22,997,361..22,997,385 bound_moiety=pan-XP evidence=experimental (Yan et al., 2004, Bergman et al., 2005) protein binding site FBsf0000160864 3R:22,997,008..22,997,015 bound_moiety=ap-XP evidence=experimental (Bergman et al., 2005, Yan et al., 2004) protein binding site FBsf0000160865 3R:22,997,687..22,997,708 bound_moiety=pan-XP evidence=experimental (Bergman et al., 2005, Yan et al., 2004) protein binding site FBsf0000160866 3R:22,997,065..22,997,083 bound_moiety=pan-XP evidence=experimental (Bergman et al., 2005, Yan et al., 2004) protein binding site FBsf0000160867 3R:22,997,753..22,997,759 bound_moiety=ap-XP evidence=experimental (Yan et al., 2004, Bergman et al., 2005) protein binding site FBsf0000160868 3R:22,997,594..22,997,604 bound_moiety=ap-XP evidence=experimental (Yan et al., 2004, Bergman et al., 2005) protein binding site FBsf0000160869 3R:22,997,018..22,997,025 bound_moiety=ap-XP evidence=experimental (Yan et al., 2004, Bergman et al., 2005) protein binding site FBsf0000160870 3R:22,997,721..22,997,735 bound_moiety=pan-XP evidence=experimental (Bergman et al., 2005, Yan et al., 2004) protein binding site FBsf0000160871 3R:22,997,776..22,997,782 bound_moiety=ap-XP evidence=experimental (Yan et al., 2004, Bergman et al., 2005) protein binding site FBsf0000160872 3R:22,997,245..22,997,260 bound_moiety=pan-XP evidence=experimental (Yan et al., 2004, Bergman et al., 2005) protein binding site FBsf0000160873 3R:22,997,058..22,997,065 bound_moiety=ap-XP evidence=experimental (Bergman et al., 2005, Yan et al., 2004) protein binding site FBsf0000160874 3R:22,997,400..22,997,417 bound_moiety=pan-XP evidence=experimental (Yan et al., 2004, Bergman et al., 2005) protein binding site FBsf0000160875 3R:22,997,606..22,997,624 bound_moiety=pan-XP evidence=experimental (Bergman et al., 2005, Yan et al., 2004) protein binding site FBsf0000160876 3R:22,997,200..22,997,212 evidence=experimental bound_moiety=ap-XP (Yan et al., 2004, Bergman et al., 2005) protein binding site FBsf0000160877 3R:22,997,413..22,997,422 bound_moiety=ap-XP evidence=experimental (Bergman et al., 2005, Yan et al., 2004) protein binding site FBsf0000160878 3R:22,997,585..22,997,593 bound_moiety=Su(H)-XP evidence=experimental (Yan et al., 2004, Bergman et al., 2005) protein binding site FBsf0000160879 3R:22,997,174..22,997,188 bound_moiety=ap-XP evidence=experimental (Yan et al., 2004, Bergman et al., 2005) protein binding site FBsf0000160880 3R:22,997,591..22,997,600 bound_moiety=pan-XP evidence=experimental (Yan et al., 2004, Bergman et al., 2005) regulatory region FBsf0000435108 3R:23,033,175..23,034,589 evidence=Reporter construct (in vivo) (Bachmann and Knust, 1998, Halfon, 2012.6.19) regulatory region FBsf0000435120 3R:23,019,754..23,021,951 evidence=Reporter construct (in vivo) (Bachmann and Knust, 1998, Halfon, 2012.6.19) regulatory region FBsf0000435228 3R:22,997,005..22,997,816 evidence=Reporter construct (in vivo) (Yan et al., 2004, Halfon, 2012.6.19) regulatory region FBsf0000435316 3R:23,024,934..23,034,589 evidence=Reporter construct (in vivo) (Bachmann and Knust, 1998, Halfon, 2012.6.19) regulatory region FBsf0000435729 3R:23,025,778..23,029,817 evidence=Reporter construct (in vivo) (Yan et al., 2004, Halfon, 2012.6.19) regulatory region FBsf0000435759 3R:23,028,638..23,033,175 evidence=Reporter construct (in vivo) (Bachmann and Knust, 1998, Halfon, 2012.6.19) regulatory region FBsf0000435991 3R:23,013,611..23,016,661 evidence=Reporter construct (in vivo) (Bachmann and Knust, 1998, Halfon, 2012.6.19) regulatory region FBsf0000436151 3R:22,990,339..22,999,650 evidence=Reporter construct (in vivo) (Yan et al., 2004, Halfon, 2012.6.19) regulatory region FBsf0000436501 3R:23,011,597..23,013,611 evidence=Reporter construct (in vivo) (Bachmann and Knust, 1998, Halfon, 2012.6.19) regulatory region FBsf0000436534 3R:23,017,502..23,024,929 evidence=Reporter construct (in vivo) (Yan et al., 2004, Halfon, 2012.6.19) regulatory region FBsf0000436653 3R:23,017,326..23,024,934 evidence=Reporter construct (in vivo) (Bachmann and Knust, 1998, Halfon, 2012.6.19) regulatory region FBsf0000436836 3R:23,024,934..23,028,638 evidence=Reporter construct (in vivo) (Bachmann and Knust, 1998, Halfon, 2012.6.19)
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference embryonic stage   embryonic/larval pharynx   (Thomas et al., 1991, Fleming et al., 1990) frontal head air sac | ventral   (Thomas et al., 1991) anal pad   (Thomas et al., 1991) maxillary segment   (Thomas et al., 1991) trachea   (Thomas et al., 1991, Fleming et al., 1990) embryonic/larval posterior spiracle   (Thomas et al., 1991) embryonic/larval proventriculus   (Thomas et al., 1991, Fleming et al., 1990) embryonic/larval hindgut   (Thomas et al., 1991, Fleming et al., 1990) embryonic/larval hypopharynx   (Fleming et al., 1990) supraesophageal ganglion   (Fleming et al., 1990) epidermis | striped   (Thomas et al., 1991) third instar larval stage   alula   (Thomas et al., 1991) adult stage | female     (Thomas et al., 1991) in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage   presumptive embryonic salivary gland   (Haberman et al., 2003) central nervous system   (Fleming et al., 1990) embryonic/larval anterior spiracle   (Fleming et al., 1990, Thomas et al., 1991) embryonic/larval foregut   (Fleming et al., 1990, Thomas et al., 1991) embryonic/larval salivary gland   (Fleming et al., 1990, Thomas et al., 1991) maxillary lobe   (Fleming et al., 1990) telson   (Fleming et al., 1990) epidermis   (Thomas et al., 1991) labial segment   (Thomas et al., 1991) labral segment   (Thomas et al., 1991) mandibular segment   (Thomas et al., 1991) stomodeum   (Thomas et al., 1991) supraesophageal ganglion   (Thomas et al., 1991) embryonic stage 13   small intestine primordium   (Iwaki et al., 2001) rectum primordium   (Iwaki et al., 2001) third instar larval stage   wing disc   (Thomas et al., 1991) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage 5 -- 9     (Fleming et al., 1990) Comment:reference states 2-4 hr AEL adult stage | male     (Thomas et al., 1991)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference embryonic stage   embryonic/larval anterior spiracle   (Thomas et al., 1991) embryonic/larval pharynx   (Thomas et al., 1991) commissure   (Thomas et al., 1991) frontal head air sac | ventral   (Thomas et al., 1991) maxillary segment   (Thomas et al., 1991) trachea   (Thomas et al., 1991) embryonic/larval proventriculus   (Thomas et al., 1991) embryonic/larval hindgut   (Thomas et al., 1991) anal pad   (Thomas et al., 1991) third instar larval stage   wing disc   (Thomas et al., 1991) immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage   epidermis | striped   (Thomas et al., 1991) embryonic/larval salivary gland   (Thomas et al., 1991) embryonic/larval posterior spiracle   (Thomas et al., 1991) stomodeum   (Thomas et al., 1991) mandibular segment   (Thomas et al., 1991) embryonic/larval foregut   (Thomas et al., 1991) labral segment   (Thomas et al., 1991) epidermis   (Thomas et al., 1991) labial segment   (Thomas et al., 1991) supraesophageal ganglion   (Thomas et al., 1991) embryonic stage 15   embryonic ventral epidermis | segmentally repeated   (Bachmann and Knust, 1998) embryonic/larval trachea   (Bachmann and Knust, 1998) embryonic/larval pharynx   (Bachmann and Knust, 1998) frontal sac   (Bachmann and Knust, 1998) embryonic proventriculus   (Bachmann and Knust, 1998) embryonic salivary gland duct   (Bachmann and Knust, 1998) embryonic stage 17   dorsal mesothoracic disc primordium   (Bachmann and Knust, 1998) dorsal metathoracic disc primordium   (Bachmann and Knust, 1998) second instar larval stage   wing disc   (Milan et al., 2004) eye disc | dorsal/ventral compartment boundary   (Bachmann and Knust, 1998) wing disc | dorsal compartment   (Bachmann and Knust, 1998) third instar larval stage   alula   (Thomas et al., 1991) eye disc | anterior & restricted   (Bachmann and Knust, 1998) Comment:anterior border of disc wing disc | restricted   (Bachmann and Knust, 1998) ventral thoracic disc | restricted   (Bachmann and Knust, 1998) Comment:concentric rings
Additional Descriptive Data
	Ser protein is first observed in stage 11 embryos in the clypeolabrum anlage and later in the hypopharyngeal lobe. These regions later form the roof and floor of the pharynx. In late stage 11, expression is observed in a ring of cells surrounding the stomodeum which come to lie in the anterior part of the proventriculus. Beginning in stage 11, a metameric pattern of expression is seen in the epidermis. Expression is also observed in the gnathal segments and in the anlage of the anal pads. From stage 12 onward, two defined regions of expression are apparent in the hindgut . From stage 13 onward, expression is observed in the two main lateral trunks of the tracheal system and in the anterior and posterior spiracles. Expression is detected in the secretory ducts of the salivary glands and on the ventral side of the frontal sac from stage 14 onward. Finally, from stage 15 onward, expression is observed in the anterior and posterior commissures of each segment as well as in the roots of the segmental nerves and in some axons in the brain. In wing imaginal discs, expression is observed in a row of cells located across the wing pouch, in three stripes perpendicular to it, and in some regions at the border of the wing disc. These regions correspond to the future wing margin and anlage of the alula. (Thomas et al., 1991) Ser is expressed at both sides of the DV boundary and along the longitudinal veins. (Milan et al., 2004) During the third larval instar, the expression of Ser protein is re- solved into a complex pattern that includes two stripes of expression dorsal and ventral to the wing margin and ex- pression domains on the ventral and dorsal wing blades, including prospective wing veins 3–5. (Bachmann and Knust, 1998)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
apical plasma membrane inferred from direct assay (Glittenberg et al., 2006) axolemma inferred from direct assay (Thomas et al., 1991) cell surface inferred from direct assay (Kim et al., 2010) plasma membrane inferred from direct assay (Thomas et al., 1991)
Expression Deduced from Reporters
Reporter: P{Ser-GAL4.GF} Stage Tissue/Position (including subcellular localization) Reference third instar larval stage   wing disc | distal   (Fleming et al., 1997) wing disc | dorsal   (Fleming et al., 1997) wandering third instar larval stage   embryonic/larval proventriculus   (Cherbas et al., 2003) wing disc | restricted   (Cherbas et al., 2003)
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult hindgut, larval trachea. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    33.775 Larval Midgut    21.9 Larval Hindgut    58.3 Larval Malpighian Tubules    8.2 Larval Fat Body    27.1 Larval Salivary Gland    50.1 Larval Trachea    177.025 Larval Carcass    64.85 Adult Head    10.5 Adult Eye    8.925 Adult Brain    5.8 Adult Thoracic-Abdominal Ganglion    7.7 Adult Crop    10.2 Adult Midgut    12.8 Adult Hindgut    105.5 Adult Malpighian Tubules    7.4 Adult Fat Body    10.6 Adult Salivary Gland    13.9 Adult Heart    24.7 Adult VirginFemale Spermatheca    8.7 Adult InseminatedFemale Spermatheca    6.7 Adult Ovary    3.3 Adult Testis    38.1 Adult Male Accessory Gland    10.8 Adult Carcass    13 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    33.775 Larval Midgut    21.9 Larval Hindgut    58.3 Larval Malpighian Tubules    8.2 Larval Fat Body    27.1 Larval Salivary Gland    50.1 Larval Trachea    177.025 Larval Carcass    64.85 Adult Head    10.5 Adult Eye    8.925 Adult Brain    5.8 Adult Thoracic-Abdominal Ganglion    7.7 Adult Crop    10.2 Adult Midgut    12.8 Adult Hindgut    105.5 Adult Malpighian Tubules    7.4 Adult Fat Body    10.6 Adult Salivary Gland    13.9 Adult Heart    24.7 Adult VirginFemale Spermatheca    8.7 Adult InseminatedFemale Spermatheca    6.7 Adult Ovary    3.3 Adult Testis    38.1 Adult Male Accessory Gland    10.8 Adult Carcass    13 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    33.775 Larval Midgut    21.9 Larval Hindgut    58.3 Larval Malpighian Tubules    8.2 Larval Fat Body    27.1 Larval Salivary Gland    50.1 Larval Trachea    177.025 Larval Carcass    64.85 Adult Head    10.5 Adult Eye    8.925 Adult Brain    5.8 Adult Thoracic-Abdominal Ganglion    7.7 Adult Crop    10.2 Adult Midgut    12.8 Adult Hindgut    105.5 Adult Malpighian Tubules    7.4 Adult Fat Body    10.6 Adult Salivary Gland    13.9 Adult Heart    24.7 Adult VirginFemale Spermatheca    8.7 Adult InseminatedFemale Spermatheca    6.7 Adult Ovary    3.3 Adult Testis    38.1 Adult Male Accessory Gland    10.8 Adult Carcass    13 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    33.775 Larval Midgut    21.9 Larval Hindgut    58.3 Larval Malpighian Tubules    8.2 Larval Fat Body    27.1 Larval Salivary Gland    50.1 Larval Trachea    177.025 Larval Carcass    64.85 Adult Head    10.5 Adult Eye    8.925 Adult Brain    5.8 Adult Thoracic-Abdominal Ganglion    7.7 Adult Crop    10.2 Adult Midgut    12.8 Adult Hindgut    105.5 Adult Malpighian Tubules    7.4 Adult Fat Body    10.6 Adult Salivary Gland    13.9 Adult Heart    24.7 Adult VirginFemale Spermatheca    8.7 Adult InseminatedFemale Spermatheca    6.7 Adult Ovary    3.3 Adult Testis    38.1 Adult Male Accessory Gland    10.8 Adult Carcass    13 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    33.775 Larval Midgut    21.9 Larval Hindgut    58.3 Larval Malpighian Tubules    8.2 Larval Fat Body    27.1 Larval Salivary Gland    50.1 Larval Trachea    177.025 Larval Carcass    64.85 Adult Head    10.5 Adult Eye    8.925 Adult Brain    5.8 Adult Thoracic-Abdominal Ganglion    7.7 Adult Crop    10.2 Adult Midgut    12.8 Adult Hindgut    105.5 Adult Malpighian Tubules    7.4 Adult Fat Body    10.6 Adult Salivary Gland    13.9 Adult Heart    24.7 Adult VirginFemale Spermatheca    8.7 Adult InseminatedFemale Spermatheca    6.7 Adult Ovary    3.3 Adult Testis    38.1 Adult Male Accessory Gland    10.8 Adult Carcass    13 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    33.775 Larval Midgut    21.9 Larval Hindgut    58.3 Larval Malpighian Tubules    8.2 Larval Fat Body    27.1 Larval Salivary Gland    50.1 Larval Trachea    177.025 Larval Carcass    64.85 Adult Head    10.5 Adult Eye    8.925 Adult Brain    5.8 Adult Thoracic-Abdominal Ganglion    7.7 Adult Crop    10.2 Adult Midgut    12.8 Adult Hindgut    105.5 Adult Malpighian Tubules    7.4 Adult Fat Body    10.6 Adult Salivary Gland    13.9 Adult Heart    24.7 Adult VirginFemale Spermatheca    8.7 Adult InseminatedFemale Spermatheca    6.7 Adult Ovary    3.3 Adult Testis    38.1 Adult Male Accessory Gland    10.8 Adult Carcass    13 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    33.775 Larval Midgut    21.9 Larval Hindgut    58.3 Larval Malpighian Tubules    8.2 Larval Fat Body    27.1 Larval Salivary Gland    50.1 Larval Trachea    177.025 Larval Carcass    64.85 Adult Head    10.5 Adult Eye    8.925 Adult Brain    5.8 Adult Thoracic-Abdominal Ganglion    7.7 Adult Crop    10.2 Adult Midgut    12.8 Adult Hindgut    105.5 Adult Malpighian Tubules    7.4 Adult Fat Body    10.6 Adult Salivary Gland    13.9 Adult Heart    24.7 Adult VirginFemale Spermatheca    8.7 Adult InseminatedFemale Spermatheca    6.7 Adult Ovary    3.3 Adult Testis    38.1 Adult Male Accessory Gland    10.8 Adult Carcass    13 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    33.775 Larval Midgut    21.9 Larval Hindgut    58.3 Larval Malpighian Tubules    8.2 Larval Fat Body    27.1 Larval Salivary Gland    50.1 Larval Trachea    177.025 Larval Carcass    64.85 Adult Head    10.5 Adult Eye    8.925 Adult Brain    5.8 Adult Thoracic-Abdominal Ganglion    7.7 Adult Crop    10.2 Adult Midgut    12.8 Adult Hindgut    105.5 Adult Malpighian Tubules    7.4 Adult Fat Body    10.6 Adult Salivary Gland    13.9 Adult Heart    24.7 Adult VirginFemale Spermatheca    8.7 Adult InseminatedFemale Spermatheca    6.7 Adult Ovary    3.3 Adult Testis    38.1 Adult Male Accessory Gland    10.8 Adult Carcass    13 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    10.5   NA  Eye    8.925   NA  Brain    5.8   33.775  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    7.7   NA  Crop    no informative data   21.9  Midgut    no informative data   58.3  Hindgut    105.5   8.2  Malpighian Tubules    7.4   27.1  Fat Body    10.6   50.1  Salivary Gland    no informative data   NA  Heart    24.7   177.025  Trachea    NA   NA  VirginFemale Spermatheca    8.7   NA  InseminatedFemale Spermatheca    6.7   NA  Ovary    3.3   NA  Testis    38.1   NA  Male Accessory Gland    no informative data   64.85  Carcass    no informative data FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3    3 central nervous system, pupae P8    2 head, virgin 1-day female    1 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    3 fat body, pupae P8    3 carcass, larvae L3 wandering    12 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3    3 central nervous system, pupae P8    2 head, virgin 1-day female    1 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    3 fat body, pupae P8    3 carcass, larvae L3 wandering    12 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3    3 central nervous system, pupae P8    2 head, virgin 1-day female    1 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    3 fat body, pupae P8    3 carcass, larvae L3 wandering    12 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3    3 central nervous system, pupae P8    2 head, virgin 1-day female    1 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    3 fat body, pupae P8    3 carcass, larvae L3 wandering    12 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3    3 central nervous system, pupae P8    2 head, virgin 1-day female    1 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    3 fat body, pupae P8    3 carcass, larvae L3 wandering    12 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3    3 central nervous system, pupae P8    2 head, virgin 1-day female    1 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    3 fat body, pupae P8    3 carcass, larvae L3 wandering    12 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3    3 central nervous system, pupae P8    2 head, virgin 1-day female    1 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    3 fat body, pupae P8    3 carcass, larvae L3 wandering    12 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3    3 central nervous system, pupae P8    2 head, virgin 1-day female    1 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    3 fat body, pupae P8    3 carcass, larvae L3 wandering    12 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of extremely low expression. Peak expression observed within 06-18 hour embryonic stages, at stages throughout the pupal period. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    10 embryo 08-10hr    24 embryo 10-12hr    29 embryo 12-14hr    22 embryo 14-16hr    12 embryo 16-18hr    8 embryo 18-20hr    8 embryo 20-22hr    4 embryo 22-24hr    4 larva L1    5 larva L2    6 larva L3 12hr old    4 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    12 white prepupae new    12 white prepupae 12hr    16 white prepupae 24hr    30 pupae 2d postWPP    19 pupae 3d postWPP    7 pupae 4d postWPP    3 adult male 01day    2 adult male 05day    2 adult male 30day    2 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    10 embryo 08-10hr    24 embryo 10-12hr  (29) embryo 12-14hr    22 embryo 14-16hr    12 embryo 16-18hr    8 embryo 18-20hr    8 embryo 20-22hr    4 embryo 22-24hr    4 larva L1    5 larva L2    6 larva L3 12hr old    4 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    12 white prepupae new    12 white prepupae 12hr    16 white prepupae 24hr  (30) pupae 2d postWPP    19 pupae 3d postWPP    7 pupae 4d postWPP    3 adult male 01day    2 adult male 05day    2 adult male 30day    2 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    10 embryo 08-10hr    24 embryo 10-12hr    29 embryo 12-14hr    22 embryo 14-16hr    12 embryo 16-18hr    8 embryo 18-20hr    8 embryo 20-22hr    4 embryo 22-24hr    4 larva L1    5 larva L2    6 larva L3 12hr old    4 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    12 white prepupae new    12 white prepupae 12hr    16 white prepupae 24hr    30 pupae 2d postWPP    19 pupae 3d postWPP    7 pupae 4d postWPP    3 adult male 01day    2 adult male 05day    2 adult male 30day    2 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    10 embryo 08-10hr    24 embryo 10-12hr    29 embryo 12-14hr    22 embryo 14-16hr    12 embryo 16-18hr    8 embryo 18-20hr    8 embryo 20-22hr    4 embryo 22-24hr    4 larva L1    5 larva L2    6 larva L3 12hr old    4 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    12 white prepupae new    12 white prepupae 12hr    16 white prepupae 24hr    30 pupae 2d postWPP    19 pupae 3d postWPP    7 pupae 4d postWPP    3 adult male 01day    2 adult male 05day    2 adult male 30day    2 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    10 embryo 08-10hr    24 embryo 10-12hr    29 embryo 12-14hr    22 embryo 14-16hr    12 embryo 16-18hr    8 embryo 18-20hr    8 embryo 20-22hr    4 embryo 22-24hr    4 larva L1    5 larva L2    6 larva L3 12hr old    4 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    12 white prepupae new    12 white prepupae 12hr    16 white prepupae 24hr    30 pupae 2d postWPP    19 pupae 3d postWPP    7 pupae 4d postWPP    3 adult male 01day    2 adult male 05day    2 adult male 30day    2 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    10 embryo 08-10hr    24 embryo 10-12hr  29 embryo 12-14hr    22 embryo 14-16hr    12 embryo 16-18hr    8 embryo 18-20hr    8 embryo 20-22hr    4 embryo 22-24hr    4 larva L1    5 larva L2    6 larva L3 12hr old    4 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    12 white prepupae new    12 white prepupae 12hr    16 white prepupae 24hr  30 pupae 2d postWPP    19 pupae 3d postWPP    7 pupae 4d postWPP    3 adult male 01day    2 adult male 05day    2 adult male 30day    2 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    10 embryo 08-10hr    24 embryo 10-12hr    29 embryo 12-14hr    22 embryo 14-16hr    12 embryo 16-18hr    8 embryo 18-20hr    8 embryo 20-22hr    4 embryo 22-24hr    4 larva L1    5 larva L2    6 larva L3 12hr old    4 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    12 white prepupae new    12 white prepupae 12hr    16 white prepupae 24hr    30 pupae 2d postWPP    19 pupae 3d postWPP    7 pupae 4d postWPP    3 adult male 01day    2 adult male 05day    2 adult male 30day    2 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    10 embryo 08-10hr    24 embryo 10-12hr    29 embryo 12-14hr    22 embryo 14-16hr    12 embryo 16-18hr    8 embryo 18-20hr    8 embryo 20-22hr    4 embryo 22-24hr    4 larva L1    5 larva L2    6 larva L3 12hr old    4 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    12 white prepupae new    12 white prepupae 12hr    16 white prepupae 24hr    30 pupae 2d postWPP    19 pupae 3d postWPP    7 pupae 4d postWPP    3 adult male 01day    2 adult male 05day    2 adult male 30day    2 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    2 embryonic 1182-4H    5 embryonic GM2    14 embryonic Kc167    0 embryonic S1    0 embryonic S3    1 leg disc CME L1    3 wing disc CME-W2    2 wing disc ML-DmD8    0 wing disc ML-DmD9    1 wing disc ML-DmD16-c3    30 wing disc ML-DmD21    1 wing disc ML-DmD32    6 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    7 antennal disc ML-DmD20-c5    6 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    6 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    2 embryonic 1182-4H    5 embryonic GM2    14 embryonic Kc167    0 embryonic S1    0 embryonic S3    1 leg disc CME L1    3 wing disc CME-W2    2 wing disc ML-DmD8    0 wing disc ML-DmD9    1 wing disc ML-DmD16-c3  (30) wing disc ML-DmD21    1 wing disc ML-DmD32    6 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    7 antennal disc ML-DmD20-c5    6 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    6 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    2 embryonic 1182-4H    5 embryonic GM2    14 embryonic Kc167    0 embryonic S1    0 embryonic S3    1 leg disc CME L1    3 wing disc CME-W2    2 wing disc ML-DmD8    0 wing disc ML-DmD9    1 wing disc ML-DmD16-c3    30 wing disc ML-DmD21    1 wing disc ML-DmD32    6 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    7 antennal disc ML-DmD20-c5    6 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    6 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    2 embryonic 1182-4H    5 embryonic GM2    14 embryonic Kc167    0 embryonic S1    0 embryonic S3    1 leg disc CME L1    3 wing disc CME-W2    2 wing disc ML-DmD8    0 wing disc ML-DmD9    1 wing disc ML-DmD16-c3    30 wing disc ML-DmD21    1 wing disc ML-DmD32    6 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    7 antennal disc ML-DmD20-c5    6 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    6 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    2 embryonic 1182-4H    5 embryonic GM2    14 embryonic Kc167    0 embryonic S1    0 embryonic S3    1 leg disc CME L1    3 wing disc CME-W2    2 wing disc ML-DmD8    0 wing disc ML-DmD9    1 wing disc ML-DmD16-c3    30 wing disc ML-DmD21    1 wing disc ML-DmD32    6 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    7 antennal disc ML-DmD20-c5    6 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    6 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    2 embryonic 1182-4H    5 embryonic GM2    14 embryonic Kc167    0 embryonic S1    0 embryonic S3    1 leg disc CME L1    3 wing disc CME-W2    2 wing disc ML-DmD8    0 wing disc ML-DmD9    1 wing disc ML-DmD16-c3  30 wing disc ML-DmD21    1 wing disc ML-DmD32    6 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    7 antennal disc ML-DmD20-c5    6 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    6 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    2 embryonic 1182-4H    5 embryonic GM2    14 embryonic Kc167    0 embryonic S1    0 embryonic S3    1 leg disc CME L1    3 wing disc CME-W2    2 wing disc ML-DmD8    0 wing disc ML-DmD9    1 wing disc ML-DmD16-c3    30 wing disc ML-DmD21    1 wing disc ML-DmD32    6 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    7 antennal disc ML-DmD20-c5    6 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    6 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    2 embryonic 1182-4H    5 embryonic GM2    14 embryonic Kc167    0 embryonic S1    0 embryonic S3    1 leg disc CME L1    3 wing disc CME-W2    2 wing disc ML-DmD8    0 wing disc ML-DmD9    1 wing disc ML-DmD16-c3    30 wing disc ML-DmD21    1 wing disc ML-DmD32    6 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    7 antennal disc ML-DmD20-c5    6 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    6 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_11 mE1_20_mRNA_expression_cluster_05
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004197 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6127-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal Ser+r83k lethal, with Scer\GAL4e22c SerBd.Scer\UAS.T:Hsap\MYC SerScer\UAS.cGa lethal, with Scer\GAL4hs.PB SerBd.Scer\UAS.T:Hsap\MYC SerScer\UAS.cGa lethal (with SerBd-1) SerBd-3 lethal (with SerBd-3) SerBd-1 lethal | embryonic stage SerBd-r2 SerBd-r3 Serrev2-11 Serrev3 lethal | embryonic stage, with Scer\GAL4hs.PB SerScer\UAS.cGa lethal | embryonic stage | recessive SerBd-3 Serrev2-3 Serrev5-5 Serrev6-1 lethal | larval stage | recessive SerBd-3 SerRx50 SerRX82 SerRx103 SerRX106 SerRX107 SerRx111 SerRx112 SerRx120 lethal | pharate adult stage, with Scer\GAL4ptc-559.1 SerScer\UAS.cSa lethal | pupal stage, with Scer\GAL4ptc-559.1 SerBd.Scer\UAS.T:Hsap\MYC lethal | pupal stage (with Ser+r83k) SerBd-3 lethal | pupal stage (with SerBd-3) Ser+r83k lethal | pupal stage | recessive SerRx119 lethal | recessive SerBd-1 SerBd-3 SerBd-5 SerBd-r2 SerBd-r4 Serrev2-3 Serrev3 Serrev5-5 Serrev6-1 viable SerD viable, with Scer\GAL4pnr-MD237 SerGD147 SerGD14453 viable | recessive Ser1 Sterility Allele male fertile SerBd-3rev2A SerBd-3rev7A Other Phenotypes Allele body color defective, with Scer\GAL4pnr-MD237 SerGD14453 cell polarity defective SerRX82 mitotic cell cycle defective, with Scer\GAL4ey.PB SerDN.Scer\UAS mitotic cell cycle defective, with Scer\GAL4ey.PH SerDN.Scer\UAS neuroanatomy defective, with Scer\GAL4h-H10 SerY1248S.F2I.Scer\UAS neuroanatomy defective, with Scer\GAL4htl.POS SerScer\UAS.cUa neuroanatomy defective, with Scer\GAL4sca-537.4 SerY1248S.F2I.Scer\UAS neuroanatomy defective | recessive Serrev5-5 visible SerM8-1 visible, with Scer\GAL4A9 SerS.Scer\UAS.T:Hsap\MYC visible, with Scer\GAL4Act5C.PI SerScer\UAS.cSa visible, with Scer\GAL4ap-md544 SerScer\UAS.cSa visible, with Scer\GAL4Bx-MS1096 SerScer\UAS.cSa visible, with Scer\GAL4c311 SerS.Scer\UAS.T:Hsap\MYC visible, with Scer\GAL4dpp.blk1 SerScer\UAS.cSa visible, with Scer\GAL4hs.2sev SerS.Scer\UAS.T:Hsap\MYC visible, with Scer\GAL4klu-G410 SerScer\UAS.cSa visible, with Scer\GAL4l(3)31-1-31-1 SerScer\UAS.cGa visible, with Scer\GAL4pnr-MD237 SerGD14453 visible, with Scer\GAL4ptc-559.1 SerScer\UAS.cSa visible, with Scer\GAL4T113 SerS.Scer\UAS.T:Hsap\MYC visible, with Scer\GAL4Ubx.PdC SerScer\UAS.cSa visible, with Scer\GAL4vg.int2.1 SerS.Scer\UAS.T:Hsap\MYC SerScer\UAS.cSa visible | dominant SerD visible | dominant | cold sensitive SerBd-3 SerRpw visible | heat sensitive SerBd-3 visible | homeotic | heat sensitive, with Scer\GAL4ey.PB SerDN.Scer\UAS visible | recessive SerCS94 SerRX106 visible | somatic clone Serrev2-11 SerRX82 SerRX106 SerRX107 Phenotype manifest in Allele actin filament & larval salivary gland SerRX82 adult abdominal segment 4 SerRX82 adult abdominal segment 5 SerRX82 adult abdominal segment 6 SerRX82 adult abdominal segment 7 SerRX82 adult heart, with Scer\GAL4tin.CΔ4 SerVDRC.cUa adult heart | heat sensitive, with Scer\GAL4tin.CΔ4, Scer\GAL80ts.αTub84B SerDN.Scer\UAS antenna | ectopic | heat sensitive, with Scer\GAL4ey.PB SerDN.Scer\UAS antenna | supernumerary, with Scer\GAL4ey.PB SerDN.Scer\UAS antenna | supernumerary, with Scer\GAL4ey.PH SerDN.Scer\UAS anterior dorsocentral bristle & trichogen cell, with Scer\GAL4l(3)31-1-31-1 SerScer\UAS.cGa anterior notopleural bristle & trichogen cell, with Scer\GAL4l(3)31-1-31-1 SerScer\UAS.cGa anterior postalar bristle & trichogen cell, with Scer\GAL4l(3)31-1-31-1 SerScer\UAS.cGa anterior scutellar bristle & trichogen cell, with Scer\GAL4l(3)31-1-31-1 SerScer\UAS.cGa anterior supraalar bristle & trichogen cell, with Scer\GAL4l(3)31-1-31-1 SerScer\UAS.cGa axon Serrev5-5 commissure Serrev5-5 crystal cell SerBd-3 crystal cell | larval stage (with Df(3R)D605) SerRX82 crystal cell | larval stage | heat sensitive, with Scer\GAL4hs.PB SerScer\UAS.cSa cuticle Serrev5-5 denticle Serrev5-5 denticle row 3 SerRX82 denticle row 3 & abdominal 2 ventral denticle belt SerRX106 denticle row 3 & abdominal 3 ventral denticle belt Ser5A29 SerRX106 Serrev6-1 denticle row 3 & abdominal 4 ventral denticle belt Ser5A29 SerRX106 Serrev6-1 denticle row 3 & abdominal 5 ventral denticle belt Ser5A29 SerRX106 Serrev6-1 denticle row 3 & abdominal 6 ventral denticle belt Ser5A29 SerRX106 Serrev6-1 denticle row 3 & abdominal 7 ventral denticle belt Ser5A29 SerRX106 Serrev6-1 denticle row 3 & abdominal 8 ventral denticle belt Ser5A29 SerRX106 Serrev6-1 denticle row 4 SerRX82 denticle row 4 & abdominal 2 ventral denticle belt Ser5A29 SerRX106 Serrev6-1 denticle row 4 & abdominal 3 ventral denticle belt Ser5A29 SerRX106 Serrev6-1 denticle row 4 & abdominal 4 ventral denticle belt Ser5A29 SerRX106 Serrev6-1 denticle row 4 & abdominal 5 ventral denticle belt Ser5A29 SerRX106 Serrev6-1 denticle row 4 & abdominal 6 ventral denticle belt Ser5A29 SerRX106 Serrev6-1 denticle row 4 & abdominal 7 ventral denticle belt Ser5A29 SerRX106 Serrev6-1 denticle row 4 & abdominal 8 ventral denticle belt Ser5A29 SerRX106 Serrev6-1 dorsal bridge SerRX106 dorsal bridge, with Scer\GAL4arm.PS SerScer\UAS.cGa dorsal closure embryo Serrev5-5 dorsal hair Serrev5-5 dorsal pouch SerRX106 dorsal pouch, with Scer\GAL4arm.PS SerScer\UAS.cGa dorsal row, with Scer\GAL4ptc-559.1 SerScer\UAS.cSa embryonic/larval anterior spiracle SerRX106 SerRX107 SerRX82 SerRx103 SerRx111 SerRx112 SerRx50 Serunspecified embryonic/larval digestive system | embryonic stage SerRX106 embryonic/larval digestive system | embryonic stage, with Scer\GAL4arm.PS SerScer\UAS.cGa embryonic/larval lymph gland, with Scer\GAL4Scer\FRT.Act5C SerScer\UAS.cSa embryonic/larval lymph gland | larval stage, with Scer\GAL4hs.PB SerScer\UAS.cSa embryonic/larval proventriculus | embryonic stage SerRX106 embryonic/larval proventriculus | embryonic stage, with Scer\GAL4arm.PS SerScer\UAS.cGa embryonic/larval salivary gland duct SerRX82 embryonic epidermis, with Scer\GAL4hs.PB SerBd.Scer\UAS.T:Hsap\MYC embryonic head SerBd-3 Serrev6-1 embryonic head, with Scer\GAL4e22c SerBd.Scer\UAS.T:Hsap\MYC eye SerBd-3 SerS.GMR.T:Hsap\MYC eye, with Scer\GAL4c311 SerS.Scer\UAS.T:Hsap\MYC eye, with Scer\GAL4ey.PB SerDN.Scer\UAS eye, with Scer\GAL4ey.PH SerDN.Scer\UAS SerScer\UAS.cSa eye, with Scer\GAL4hs.2sev SerS.Scer\UAS.T:Hsap\MYC eye, with Scer\GAL4T113 SerS.Scer\UAS.T:Hsap\MYC eye | heat sensitive, with Scer\GAL4ey.PB SerDN.Scer\UAS eye | somatic clone, with Scer\GAL4Act5C.PP SerBd.Scer\UAS.T:Hsap\MYC eye | ventral, with Scer\GAL4ey.PH SerBd.Scer\UAS.T:Hsap\MYC eye-antennal disc, with Scer\GAL4ey.PB SerDN.Scer\UAS eye-antennal disc, with Scer\GAL4ey.PH SerDN.Scer\UAS eye disc, with Scer\GAL4ey.PH SerBd.Scer\UAS.T:Hsap\MYC eye disc | dorsal, with Scer\GAL4bi-omb-Gal4 SerBd.Scer\UAS.T:Hsap\MYC eye disc | somatic clone, with Scer\GAL4Act5C.PP SerBd.Scer\UAS.T:Hsap\MYC eye disc | ventral, with Scer\GAL4bi-omb-Gal4 SerBd.Scer\UAS.T:Hsap\MYC eye disc | ventral, with Scer\GAL4ey.PH SerBd.Scer\UAS.T:Hsap\MYC eye photoreceptor cell SerS.GMR.T:Hsap\MYC eye photoreceptor cell, with Scer\GAL4hs.2sev SerS.Scer\UAS.T:Hsap\MYC eye photoreceptor cell & eye disc, with Scer\GAL4h-H10 SerY1248S.F2I.Scer\UAS eye photoreceptor cell & eye disc | posterior, with Scer\GAL4sca-537.4 SerY1248S.F2I.Scer\UAS femur Ser+r83k SerBd-3 femur, with Scer\GAL4dpp.blk1 SerScer\UAS.cSa femur, with Scer\GAL4klu-G410 SerScer\UAS.cSa haltere (with Ser+r83k) SerBd-3 haltere (with SerBd-3) Ser+r83k hub cell | first instar larval stage SerRX106 hub cell | first instar larval stage | supernumerary, with Scer\GAL4nos.UTR.T:Hsim\VP16 SerScer\UAS.cGa interface glial cell, with Scer\GAL4htl.POS SerScer\UAS.cUa interommatidial bristle SerS.GMR.T:Hsap\MYC SerS.sev.T:Hsap\MYC SerS2.sev.T:Hsap\MYC Sersev.T:VSV\G interommatidial bristle, with Scer\GAL4hs.2sev SerS.Scer\UAS.T:Hsap\MYC joint SerRX106 joint, with Scer\GAL4Act5C.PI SerScer\UAS.cSa lateral process SerRX106 lateral process, with Scer\GAL4arm.PS SerScer\UAS.cGa leg Ser+r83k SerBd-3 leg, with Scer\GAL4Act5C.PI SerScer\UAS.cSa leg, with Scer\GAL4klu-G410 SerScer\UAS.cSa leg, with Scer\GAL4ptc-559.1 SerBd.Scer\UAS.T:Hsap\MYC leg (with Serrev6-1) SerRX82 leg (with SerRX82) Serrev6-1 leg & joint SerRX106 lens SerS.GMR.T:Hsap\MYC lens, with Scer\GAL4hs.2sev SerS.Scer\UAS.T:Hsap\MYC macrochaeta & scutellum | supernumerary | somatic clone | cell autonomous, with Scer\GAL4sca-109-68 SerY1248S.F2I.Scer\UAS macrochaeta & thorax | somatic clone, with Scer\GAL4Ubx.PdC SerY1248S.F2I.Scer\UAS macrochaeta & thorax | supernumerary, with Scer\GAL4sca-537.4 SerY1248S.F2I.Scer\UAS macrochaeta & thorax | supernumerary | somatic clone, with Scer\GAL4Ubx.PdC SerY1248S.F2I.Scer\UAS macrochaeta & wing, with Scer\GAL4h-540.3 SerScer\UAS.cSa macrochaeta & wing, with Scer\GAL4ptc-559.1 SerScer\UAS.cSa macrochaeta | ectopic, with Scer\GAL4dpp.blk1 SerScer\UAS.cSa macrochaeta | ectopic (with Serrev6-1) SerRX82 macrochaeta | ectopic (with SerRX82) Serrev6-1 mesothoracic metatarsus (with Ser+r83k) SerBd-3 mesothoracic metatarsus (with SerBd-3) Ser+r83k mesothoracic tarsal segment 2 (with Ser+r83k) SerBd-3 mesothoracic tarsal segment 2 (with SerBd-3) Ser+r83k mesothoracic tergum, with Scer\GAL4pnr-MD237 SerGD14453 metathoracic metatarsus (with Ser+r83k) SerBd-3 metathoracic metatarsus (with SerBd-3) Ser+r83k metathoracic tarsal segment 2 (with Ser+r83k) SerBd-3 metathoracic tarsal segment 2 (with SerBd-3) Ser+r83k microchaeta, with Scer\GAL4l(3)31-1-31-1 SerScer\UAS.cGa morphogenetic furrow, with Scer\GAL4dpp.blk1 SerDN.Scer\UAS morphogenetic furrow, with Scer\GAL4ey.PB SerDN.Scer\UAS mouth hooks Ser5A29 SerBd-3 SerRX106 SerRX107 SerRX82 SerRx103 SerRx111 SerRx112 SerRx50 Serrev6-1 mouth hooks, with Scer\GAL4arm.PS SerScer\UAS.cGa mouth hooks, with Scer\GAL4e22c SerBd.Scer\UAS.T:Hsap\MYC neuron, with Scer\GAL4hs.PB SerScer\UAS.cGa ommatidium SerS.GMR.T:Hsap\MYC SerTM.sev.T:VSV\G Sersev.T:VSV\G ommatidium, with Scer\GAL4c311 SerS.Scer\UAS.T:Hsap\MYC ommatidium, with Scer\GAL4hs.2sev SerS.Scer\UAS.T:Hsap\MYC ommatidium, with Scer\GAL4T113 SerS.Scer\UAS.T:Hsap\MYC papilla of larval anterior spiracle SerRX106 SerRX107 SerRX82 SerRx103 SerRx111 SerRx112 SerRx50 photoreceptor cell R7 SerS.GMR.T:Hsap\MYC photoreceptor cell R7, with Scer\GAL4hs.2sev SerS.Scer\UAS.T:Hsap\MYC pigment cell SerS.GMR.T:Hsap\MYC pigment cell, with Scer\GAL4hs.2sev SerS.Scer\UAS.T:Hsap\MYC posterior dorsocentral bristle & trichogen cell, with Scer\GAL4l(3)31-1-31-1 SerScer\UAS.cGa posterior notopleural bristle & trichogen cell, with Scer\GAL4l(3)31-1-31-1 SerScer\UAS.cGa posterior postalar bristle & trichogen cell, with Scer\GAL4l(3)31-1-31-1 SerScer\UAS.cGa posterior supraalar bristle & trichogen cell, with Scer\GAL4l(3)31-1-31-1 SerScer\UAS.cGa presumptive embryonic/larval nervous system, with Scer\GAL4hs.PB SerBd.Scer\UAS.T:Hsap\MYC SerScer\UAS.cGa presutural bristle & trichogen cell, with Scer\GAL4l(3)31-1-31-1 SerScer\UAS.cGa procrystal cell | ectopic, with Scer\GAL4Scer\FRT.Act5C SerScer\UAS.cSa procrystal cell | somatic clone SerRX82 prothoracic metatarsus (with Ser+r83k) SerBd-3 prothoracic metatarsus (with SerBd-3) Ser+r83k prothoracic tarsal segment 2 (with Ser+r83k) SerBd-3 prothoracic tarsal segment 2 (with SerBd-3) Ser+r83k rhabdomere SerTM.sev.T:VSV\G Sersev.T:VSV\G salivary gland imaginal ring Ser5A29 SerRX82 scutum, with Scer\GAL4Bx-MS1096 SerScer\UAS.cSa scutum & macrochaeta, with Scer\GAL4Bx-MS1096 SerScer\UAS.cSa scutum & macrochaeta & trichogen cell, with Scer\GAL4l(3)31-1-31-1 SerScer\UAS.cGa tarsal segment 1 & joint SerRX106 tarsal segment 2 & joint SerRX106 tarsal segment 3 & joint SerRX106 tarsal segment 4, with Scer\GAL4klu-G410 SerScer\UAS.cSa tarsal segment 4 & joint SerRX106 tarsal segment 5 & joint SerRX106 tarsal segment, with Scer\GAL4dpp.blk1 SerScer\UAS.cSa tibia Ser+r83k SerBd-3 tibia, with Scer\GAL4dpp.blk1 SerScer\UAS.cSa tibia, with Scer\GAL4klu-G410 SerScer\UAS.cSa trichogen cell, with Scer\GAL4pnr-MD237 SerGD14453 ventral row, with Scer\GAL4ptc-559.1 SerScer\UAS.cSa wing Ser+r83k Ser1 SerBd-1 SerBd-3 SerCS94 SerD SerM8-1 SerRX106 SerRX82 wing, with Scer\GAL4A9 SerS.Scer\UAS.T:Hsap\MYC wing, with Scer\GAL4ap-md544 SerScer\UAS.cSa wing, with Scer\GAL4Bx-MS1096 SerScer\UAS.cSa wing, with Scer\GAL4dpp.blk1 SerScer\UAS.cSa wing, with Scer\GAL4h-540.3 SerScer\UAS.cSa wing, with Scer\GAL4ptc-559.1 SerBd.Scer\UAS.T:Hsap\MYC SerScer\UAS.cSa wing, with Scer\GAL4sd-SG29.1 SerScer\UAS.cSa wing, with Scer\GAL4Ser.PGF SerBd.Scer\UAS.T:Hsap\MYC wing, with Scer\GAL4vg.int2.1 SerS.Scer\UAS.T:Hsap\MYC SerScer\UAS.cSa wing (with Ser+r83k) SerBd-3 wing (with SerBd-3) Ser+r83k wing (with Serrev6-1) SerRX82 wing (with SerRX82) Serrev6-1 wing & macrochaeta, with Scer\GAL4dpp.blk1 SerScer\UAS.cSa wing & macrochaeta | dorsal, with Scer\GAL4Bx-MS1096 SerScer\UAS.cSa wing | anterior SerBd-3 SerBd-3rev2A SerBd-3rev7A Serrev6-1 wing | cold sensitive SerRpw wing | distal SerBd-3 SerD wing | dorsal/ventral compartment boundary Serrev6-1 wing | dorsal compartment | somatic clone SerRX106 SerRX107 SerRX82 Serrev2-11 wing | ectopic, with Scer\GAL4ptc-559.1 SerScer\UAS.cSa wing | heat sensitive SerBd-3 wing | somatic clone, with Scer\GAL4Ubx.PdC SerScer\UAS.cSa wing | ventral, with Scer\GAL4ptc-559.1 SerScer\UAS.cSa wing | ventral, with Scer\GAL4Ubx.PdC SerScer\UAS.cSa wing disc SerRX106 SerRX107 SerRX82 SerRx103 SerRx111 SerRx112 SerRx50 wing disc, with Scer\GAL4dpp.blk1 SerScer\UAS.cSa wing disc, with Scer\GAL4ptc-559.1 SerScer\UAS.cSa wing disc (with SerCS94) SerRX106 wing disc (with SerRX106) SerCS94 wing disc | dorsal compartment, with Scer\GAL4Ser.PGF SerBd.Scer\UAS.T:Hsap\MYC wing disc | somatic clone, with Scer\GAL4Act5C.PI SerScer\UAS.cSa wing disc | ventral, with Scer\GAL4dpp.blk1 SerScer\UAS.cSa wing disc | ventral compartment, with Scer\GAL4ptc-559.1 SerScer\UAS.cGa SerScer\UAS.cSa wing margin Ser1 wing margin, with Scer\GAL4ptc-559.1 SerScer\UAS.cSa wing margin, with Scer\GAL4vg.MQ.Exel SerVDRC.cUa wing margin | ectopic, with Scer\GAL4ptc-559.1 SerScer\UAS.cSa wing margin bristle, with Scer\GAL4Bx-MS1096 SerScer\UAS.cSa wing sensillum | ectopic, with Scer\GAL4dpp.blk1 SerScer\UAS.cSa wing vein SerBd-3rev2A SerBd-3rev7A wing vein, with Scer\GAL4ap-md544 SerScer\UAS.cSa wing vein, with Scer\GAL4Bx-MS1096 SerScer\UAS.cSa wing vein, with Scer\GAL4Ubx.PdC SerScer\UAS.cSa wing vein | dorsal, with Scer\GAL4Bx-MS1096 SerScer\UAS.cSa wing vein | ectopic, with Scer\GAL4Ubx.PdC SerScer\UAS.cSa
Classical Alleles ( 39 )
For All Classical Alleles Show
Allele of Ser Class Mutagen Stocks Known lesion Ser1 spontaneous 6197 Yes SerBd-3 cold sensitive antimorphic allele - genetic evidence heat-treatment 3 Yes SerBd-1 spontaneous 2 -- SerRX82 loss of function allele, amorphic allele - genetic evidence X ray 1 Yes SerMB07731 1 -- SerMI05334 1 -- SerCS94 amorphic allele - genetic evidence 0 -- Serrev2-11 loss of function allele, amorphic allele - genetic evidence X ray 0 Yes SerRX106 amorphic allele - genetic evidence, loss of function allele X ray 0 Yes SerRX107 loss of function allele, amorphic allele - genetic evidence X ray 0 -- Ser+r83k spontaneous 0 -- Ser5A29 0 -- SerBd-2 spontaneous 0 -- SerBd-3rev2A wild-type allele Delta2-3 0 Yes SerBd-3rev7A wild-type allele Delta2-3 0 Yes SerBd-4 spontaneous 0 -- SerBd-5 X ray 0 -- SerBd-6 X ray 0 -- SerBd-r1 spontaneous 0 -- SerBd-r2 X ray ethyl methanesulfonate 0 -- SerBd-r3 ethyl methanesulfonate X ray 0 -- SerBd-r4 ethyl methanesulfonate 0 Yes SerBd-r5 X ray 0 Yes SerD neomorphic allele - genetic evidence, gain of function allele spontaneous 0 Yes SerM8-1 gamma ray 0 Yes Serrev2-3 X ray 0 -- Serrev3 X ray 0 -- Serrev5-5 X ray 0 -- Serrev6-1 X ray 0 Yes SerRpw P-element activity 0 -- SerRX102 0 -- SerRx103 X ray 0 -- SerRx111 X ray 0 -- SerRx112 X ray 0 -- SerRx119 hypomorphic allele - genetic evidence X ray 0 -- SerRx120 X ray 0 -- SerRx50 X ray 0 -- SerRX87 0 -- Serunspecified 0 --
Alleles Carried on Transgenic Constructs ( 43 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Ser Class Mutagen Stocks Known lesion SerGD14453 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes SerScer\UAS.cSa in vitro construct - regulatory fusion in vitro construct - minigene 2 Yes SerHMS01179 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes SerJF03140 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes SerKK108416 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Ser4m.MtnA in vitro construct - amino acid replacement 0 Yes Ser8m.MtnA in vitro construct - amino acid replacement 0 Yes SerBd.Scer\UAS.T:Hsap\MYC antimorphic allele - genetic evidence in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes SerDN.cHa.Scer\UAS in vitro construct - regulatory fusion 0 Yes SerDN.Scer\UAS in vitro construct - regulatory fusion 0 Yes SerDSL.Scer\UAS in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes SerF2I.Scer\UAS in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes SerGD147 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes SerGD2643 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes SerKK.Scer\UAS in vitro construct - regulatory fusion in vitro construct - amino acid replacement in vitro construct - site directed mutagenesis 0 Yes SerKKYL.Scer\UAS in vitro construct - regulatory fusion in vitro construct 0 Yes SerLL.MtnA.T:SV5\V5,T:Zzzz\His6 in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes SerLL.Scer\UAS in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes SerMtnA.PR in vitro construct - regulatory fusion 0 Yes SerMtnA.T:Hsap\ALPP in vitro construct - coding region fusion 0 Yes SerMtnA.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes SerMtnA.T:SV5\V5,T:Zzzz\His6 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes SerNNL.Scer\UAS in vitro construct - regulatory fusion in vitro construct - amino acid replacement in vitro construct - site directed mutagenesis 0 Yes SerNPL.Scer\UAS in vitro construct - regulatory fusion in vitro construct - amino acid replacement in vitro construct - site directed mutagenesis 0 Yes SerS.GMR.T:Hsap\MYC in vitro construct - coding region fusion in vitro construct - regulatory fusion in vitro construct 0 Yes SerS.hs.T:Hsap\MYC in vitro construct - coding region fusion in vitro construct - regulatory fusion in vitro construct 0 Yes SerS.Scer\UAS.T:Hsap\MYC in vitro construct - coding region fusion in vitro construct - regulatory fusion in vitro construct 0 Yes SerS.sev.T:Hsap\MYC in vitro construct - coding region fusion in vitro construct - regulatory fusion in vitro construct 0 Yes SerS2.sev.T:Hsap\MYC in vitro construct - coding region fusion in vitro construct - regulatory fusion in vitro construct 0 Yes SerScer\UAS.cGa in vitro construct - regulatory fusion 0 Yes SerScer\UAS.cLa in vitro construct - regulatory fusion 0 Yes SerScer\UAS.cUa in vitro construct - regulatory fusion 0 Yes SerScer\UAS.K.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 -- Sersev.T:VSV\G in vitro construct - regulatory fusion 0 Yes SerTM.Scer\UAS in vitro construct - regulatory fusion 0 Yes SerTM.sev.T:VSV\G in vitro construct - site directed mutagenesis 0 Yes SerVDRC.cUa in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes SerY1248S.F2I.Scer\UAS in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes SerΔC20.Scer\UAS in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes SerΔC4.Scer\UAS in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes SerΔint.MtnA.T:SV5\V5,T:Zzzz\His6 in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes SerΔint.Scer\UAS in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes SerΔT.Scer\UAS in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Bd (Fleming et al., 1990, Hukriede and Fleming, 1997) Df(3R)D605 (Couso et al., 1995, Jonsson and Knust, 1996) Df(3R)Exel6207 (Ryder, 2004.4.26) Df(3R)Exel6208 (Ryder, 2004.4.26) Df(3R)Tl-P (Hukriede and Fleming, 1997) In(3R)Serrv2-11 (Fleming et al., 1990, Sun and Artavanis-Tsakonas, 1996)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data reporter construct P{Ser.8-lacZ.Y} No P{ser.8m.pan-lacZ} No P{ser.8m.Su(H)-lacZ} No P{Ser.9-lacZ.Y} No P{Ser.10-lacZ.Y} No P{Ser.10m.ap-lacZ} No P{Ser-lacZ.I-2.2} No P{Ser-lacZ.I-2.5} No P{Ser-lacZ.I-2.8} No P{Ser-lacZ.I-3.2} No P{Ser-lacZ.I-7.5} No P{Ser-lacZ.II-1.3} No P{Ser-lacZ.II-4.0} No P{Ser-lacZ.II-4.2} No P{Ser-lacZ.II-9.5} No P{Ser-lacZ.III-3.5} No P{Ser-lacZ.IV-3.0} No P{Ser-lacZ.V-1.9} No P{Ser-lacZ.VI-4.0} No UAS construct P{GD147} NA P{GD2643} NA P{GD14453} NA P{KK108416} NA P{TRiP.HMS01179} NA P{TRiP.JF03140} NA P{UAS-Bd.H} NA P{UAS-Ser.DN.H} NA P{UAS-Ser.DN} NA P{UAS-Ser.DSL} NA P{UAS-Ser.EI} NA P{UAS-Ser.F2I} NA P{UAS-Ser.G} NA P{UAS-Ser.K.MYC} NA P{UAS-Ser.KK} NA P{UAS-Ser.KKYL} NA P{UAS-Ser.L} NA P{UAS-Ser.LL} NA P{UAS-Ser.mg5603} NA P{UAS-Ser.NNL} NA P{UAS-Ser.NPL} NA P{UAS-Ser.S} NA P{UAS-Ser.TM} NA P{UAS-Ser.U} NA P{UAS-Ser.ΔC4} NA P{UAS-Ser.ΔC20} NA P{UAS-Ser.Δint} NA P{UAS-Ser.ΔT} NA characterization construct P{GMR-Ser.S} NA P{Ser.1-GAL4.Y} NA P{Ser.2-GAL4.Y} NA P{Ser.3-GAL4.Y} NA P{Ser.4-GAL4.Y} NA P{Ser.5-GAL4.Y} NA P{Ser.6-GAL4.Y} NA P{Ser.7-GAL4.Y} NA P{sev-Ser.S2} NA P{sev-Ser.S} NA P{sev-Ser} NA P{sev-SerS2} NA P{sev-SerTM} NA P{UAS-Dl::Ser.L} NA P{UAS-NT-DL/SER} NA P{UAS-Ser::Dl.L} NA P{VDRC-Ser.U} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions ?{}Ser1 NA Mi{MIC}SerMI05334 NA P{}SerRpw NA roo{}SerBd-3 NA Tirant{}SerD NA insertion of mobile activating element P{EPg}APP-BP1HP32137 NA insertion of enhancer trap binary system Mi{ET1}SerMB07731 No
Gene Ontology: Function, Process & Cellular Component ( 29 unique terms )
Terms Based on Experimental Evidence ( 20 terms )
Molecular Function
CV term Evidence References
Notch binding inferred from physical interaction with N (Kim et al., 2010) protein binding inferred from physical interaction with mib1 (Glittenberg et al., 2006)
Biological Process
CV term Evidence References
compound eye development inferred from mutant phenotype (Singh et al., 2006) crystal cell differentiation inferred from mutant phenotype (Lebestky et al., 2003, Duvic et al., 2002) cuticle pattern formation inferred from mutant phenotype (Walters et al., 2005) eye-antennal disc development inferred from mutant phenotype (Singh et al., 2006) germ-line stem cell maintenance inferred from genetic interaction with Dl (Ward et al., 2006) imaginal disc-derived leg segmentation inferred from mutant phenotype (Rauskolb and Irvine, 1999) imaginal disc-derived wing morphogenesis inferred from mutant phenotype (Lai et al., 2005) larval lymph gland hemopoiesis inferred from expression pattern (Lebestky et al., 2003) larval salivary gland morphogenesis inferred from mutant phenotype (Haberman et al., 2003) lateral inhibition inferred from mutant phenotype (Pitsouli and Delidakis, 2005) negative regulation of Notch signaling pathway inferred from direct assay (Glittenberg et al., 2006) Notch signaling pathway inferred from mutant phenotype (Pitsouli and Delidakis, 2005) salivary gland morphogenesis inferred from mutant phenotype (Haberman et al., 2003) sensory organ development inferred from mutant phenotype (Pitsouli and Delidakis, 2005)
Cellular Component
CV term Evidence References
apical plasma membrane inferred from direct assay (Glittenberg et al., 2006) axolemma inferred from direct assay (Thomas et al., 1991) cell surface inferred from direct assay (Kim et al., 2010) plasma membrane inferred from direct assay (Thomas et al., 1991)
Terms Based on Predictions or Assertions ( 14 terms )
Molecular Function
CV term Evidence References
calcium ion binding inferred from electronic annotation with InterPro:IPR001881, InterPro:IPR018097 (FlyBase Curators et al., 2004-) epidermal growth factor receptor binding non-traceable author statement (FlyBase, 1992-) Notch binding non-traceable author statement (Kumar and Moses, 2000, Bradley et al., 2001, Sanson, 2001) traceable author statement (Lopez-Schier, 2003) receptor binding non-traceable author statement (Gonzalez-Gaitan, 2003)
Biological Process
CV term Evidence References
compound eye development traceable author statement (Gibson and Schubiger, 2001) crystal cell differentiation traceable author statement (Evans et al., 2003) dorsal/ventral lineage restriction, imaginal disc traceable author statement (McNeill, 2000) lymph gland crystal cell differentiation traceable author statement (Meister, 2004) Notch signaling pathway non-traceable author statement (Kumar and Moses, 2000, Sanson, 2001, Frankfort and Mardon, 2002) regulation of crystal cell differentiation traceable author statement (Evans and Banerjee, 2003) salivary gland development non-traceable author statement (Abrams et al., 2003) salivary gland morphogenesis non-traceable author statement (Bradley et al., 2001)
Cellular Component
CV term Evidence References
integral to membrane inferred from electronic annotation with InterPro:IPR011651 (FlyBase Curators et al., 2004-) non-traceable author statement (Gonzalez-Gaitan, 2003) integral to plasma membrane non-traceable author statement (Swiss-Prot Project Members, 1990.11.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Ser - N inferred by author, confocal microscopy (Kim et al., 2010) Ser - mib1 anti tag coimmunoprecipitation, anti tag western blot (Lai et al., 2005)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Ser allele Gene References Ser5A29 Dfd (Wiellette and McGinnis, 1999) Ser+r83k N (Brennan et al., 1999) SerBd-1 CG6194 (Thumm and Kadowaki, 2001) SerBd-3 Hsc70-4 (Hing et al., 1999) M285 (Go and Artavanis-Tsakonas, 1998) mam (Helms et al., 1999) N (Brennan et al., 1999) SerBd.Scer\UAS.T:Hsap\MYC fng (Hukriede et al., 1997) tsh (Singh et al., 2004) SerCS94 Dl (Klein and Martinez Arias, 1999) fj (Buckles et al., 2001) l(2)gd1 (Klein, 2003) vg (Klein and Martinez Arias, 1998) wg (Couso et al., 1995) SerD fz3 (Sivasankaran et al., 2000) hrg (Murata et al., 1996) kuz (Sotillos et al., 1997) sd (Shyamala and Chopra, 1999) Serrev6-1 Dfd (Wiellette and McGinnis, 1999) mam (Helms et al., 1999) Src42A (Zhang et al., 1999) SerRX82 Dl (Zeng et al., 1998) SerRX106 Dfd (Wiellette and McGinnis, 1999) Dl (Klein and Martinez Arias, 1999) fj (Buckles et al., 2001) l(2)gd1 (Klein, 2003) vg (Klein and Martinez Arias, 1998) SerScer\UAS.cGa fng (Fleming et al., 1997, Jacobsen et al., 1998) mam (Helms et al., 1999) SerScer\UAS.cSa ap (Jonsson and Knust, 1996, Klein et al., 1998, Milan and Cohen, 1999) Bx (Milan and Cohen, 2000, Milan et al., 2001, Milan et al., 2004) Chi (Milan and Cohen, 2000) fng (Milan and Cohen, 1999) N (Lawrence et al., 2000) sno (Majumdar et al., 1997) tsh (Singh et al., 2004) vg (Klein and Martinez Arias, 1998) wg (Jonsson and Knust, 1996) SerScer\UAS.cSaSerRX82 Bx (Milan and Cohen, 2000, Milan et al., 2001, Milan et al., 2004) SerTM.sev.T:VSV\G H (Sun and Artavanis-Tsakonas, 1996) unspecified Chi (Milan et al., 2001) ct (Jack and DeLotto, 1992) Dl (Hukriede and Fleming, 1997, Sun and Artavanis-Tsakonas, 1997) fng (Panin et al., 1997, Walters et al., 2005) gro (Sun and Artavanis-Tsakonas, 1996) H (Go et al., 1998, Mueller et al., 2005) mib1 (Lai et al., 2005) N (Gu et al., 1995, Sun and Artavanis-Tsakonas, 1996, Jonsson and Knust, 1996, Sun and Artavanis-Tsakonas, 1997) rho (Sturtevant and Bier, 1995, Walters et al., 2005) Su(H) (Sun and Artavanis-Tsakonas, 1997)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 68163 DroID - A comprehensive database of gene and protein interactions. • FBgn0004197 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43275 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • P18168
Orthologs
OrthoDB Orthologs (63) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6V43SZ Dipteran inclusive ortholog search EOG608NGZ Insect inclusive ortholog search EOG6VQ8J7 Arthropod inclusive ortholog search EOG60GB5T Metazoa inclusive ortholog search EOG676XS5
Orthologs in Drosophila Species (EOG6V43SZ)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Ser     Drosophila simulans   Dsim\GD18089 Y   Drosophila sechellia   Dsec\GM10127 Y   Drosophila erecta   Dere\GG12134 Y   Drosophila yakuba   Dyak\GE10581 Y   Drosophila ananassae   Dana\GF22944 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA26655     Drosophila persimilis   Dper\GL23608 Y   Drosophila willistoni   Dwil\GK11192 Y   Drosophila virilis   Dvir\GJ23176 Y   Drosophila mojavensis   Dmoj\GI10494 Y   Drosophila grimshawi   Dgri\GH21317 Y
Orthologs in non-Drosophila Dipterans (EOG608NGZ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL005082   Anopheles gambiae Malaria mosquito  Agam\AGAP004154   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ009613
Orthologs in non-Dipteran Insects (EOG6VQ8J7)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB48639 Y Apis mellifera Western honey bee  Amel\GB45005 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG001325 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG011691 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH10467 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH27190 Y Atta cephalotes Leafcutter ant  Acep\ACEP17721 Y Atta cephalotes Leafcutter ant  Acep\ACEP24702 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO20581 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO13858 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL15138 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL20907 Y Linepithema humile Argentine ant  Lhum\LH26201 Y Linepithema humile Argentine ant  Lhum\LH26251 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB27209 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB27335 Y Solenopsis invicta Red fire ant  Sinv\SINV26507 Y Solenopsis invicta Red fire ant  Sinv\SINV18563 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI009235 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI003637 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI001981 Y Bombyx mori Silkmoth  Bmor\BGIBMGA010195 Y Bombyx mori Silkmoth  Bmor\BGIBMGA000783 Y Pediculus humanus Human body louse  Phum\PHUM290740 Y Pediculus humanus Human body louse  Phum\PHUM419360 Y Tribolium castaneum Red flour beetle  Tcas\TC004114 Y Tribolium castaneum Red flour beetle  Tcas\TC010113 Y
Orthologs in non-Insect Arthropods (EOG60GB5T)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\rps16 Y Daphnia pulex Water flea  Dpux\MAN1C1 Y Ixodes scapularis Deer tick  Isca\ISCW013622 Y Ixodes scapularis Deer tick  Isca\ISCW006939 Y
Orthologs in non-Arthropod Metazoa (EOG676XS5)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_022053gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_014415gn   Danio rerio Zebrafish  Drer\ENSDARG00000014246   Danio rerio Zebrafish  Drer\jag1a   Danio rerio Zebrafish  Drer\jag2   Danio rerio Zebrafish  Drer\jag1b   Danio rerio Zebrafish  Drer\CABZ01041002.1   Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000033099   Xenopus tropicalis Western clawed frog  Xtro\jag1   Gallus gallus Domestic chicken  Ggal\JAG1   Gallus gallus Domestic chicken  Ggal\JAG2   Mus musculus House mouse  Mmus\Jag1   Mus musculus House mouse  Mmus\Jag2   Rattus norvegicus Norway rat  Rnor\Jag1   Rattus norvegicus Norway rat  Rnor\Jag2   Homo sapiens Human  Hsap\JAG2   Homo sapiens Human  Hsap\JAG1
Human Orthologs (2)
Gene OMIM HGNC Hsap\JAG2     Hsap\JAG1
AAA Orthologs (10) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD18089 Drosophila sechellia Dsec\GM10127 Drosophila erecta Dere\GG12134 Drosophila yakuba Dyak\GE10581 Drosophila ananassae Dana\GF22944 Drosophila persimilis Dper\GL23608 Drosophila willistoni Dwil\GK11192 Drosophila virilis Dvir\GJ23176 Drosophila mojavensis Dmoj\GI10494 Drosophila grimshawi Dgri\GH21317
Stocks & Reagents
Stocks Listed in FlyBase ( 6218 )
Bloomington	3354 Df(3R)roe/TM3, Ser1 5915 Df(3L)E44/TM3, Ser1 6411 Df(3L)BSC8/TM3, Ser1 5744 Dp(3;3)Cam32/TM3, Ser1 2371 flr3/TM3, Ser1 3355 Df(3R)kar-Sz8/TM3, Ser1
Kyoto	106998 Df(3R)roe/TM3, Ser1 108484 Df(3L)E44/TM3, Ser1 108775 Df(3L)BSC8/TM3, Ser1 108400 Dp(3;3)Cam32/TM3, Ser1
VDRC	v108348 P{KK108416}VIE-260B v27174 w1118 P{GD14453}v27174
	More stocks available...
Genomic Clones ( 2 )
	BACR02B05 BACR21O10 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 33 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE42104
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LP24305 RE44666 RH46608 SD24485
Other clones	60463 61619 108289 166178 214375.68 214507.13 CK01.55C.F8 CK01.62A.F2 EC051937 EC052386 EC052908 EC052912 EC053473 EC053954 EC054962 EC055331 EK031201 EK044856 EK049953 EK185023 EP18555 EP19338 RP004081572 RP004161774 RP004166591 RP004180770 RP004446378 RP004489389
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0004197 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43275
Antibody Information
	polyclonal (Rauskolb and Irvine, 1999, Thomas et al., 1991)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments	May be allelic to Ndw.
Other Comments
	One of 42 Drosophila genes identified as being most likely to reveal molecular and cellular mechanisms of nervous system development or plasticity relevant to human Mental Retardation disorders. (Inlow and Restifo, 2004) A Ser expressing signalling centre in the lymph gland may control haematopoiesis. (Lebestky et al., 2003) Glycosylation of the N protein domain 'EGF12' is necessary for fng to inhibit the activation of N signalling by Ser but is not necessary for Ser binding to N. (Lei et al., 2003) The secreted proteins encoded by hh, wg and dpp are expressed in the peripodial membrane yet they control the expression of Dl and Ser in the disc proper. (Cho et al., 2000) Ser is a strong candidate for the peripodial to columnar signal demonstrated to be important in eye development. (Gibson and Schubiger, 2000) EGF-like repeats 11 and 12, the RAM-23 and cdc10/ankyrin repeats and the region C-terminal to the cdc10/ankyrin repeats of the N protein are necessary for both Dl and Ser proteins to signal via N. Dl and Ser utilise EGF-like repeats 24-26 of N for signalling, but there are significant differences in the way they utilise these repeats. (Lawrence et al., 2000) The composite signalling of the Ser and Dl genes through N patterns the segments of the leg, leading to the development of leg joints. (Bishop et al., 1999) In cultured cells, heterotypic interactions between N protein and the ligands Dl and Ser have higher affinities than homotypic interactions between Dl protein molecules. (Klueg and Muskavitch, 1999) Candidate gene for quantitative trait locus. (Macdonald and Goldstein, 1999) Local activation of N is necessary and sufficient to promote the formation of joints between segments of the leg. This segmentation process requires the participation of Ser, Dl and fng. (Rauskolb and Irvine, 1999) Ser is required for the normal morphogenesis of the abdominal denticle belts and maxillary mouth hooks in the embryo. (Wiellette and McGinnis, 1999) ap mediates cell interactions across the DV axis of the wing by regulating the expression of Ser and fng. In ap mutants the wing is lost, this phenotype can be rescued by ectopic expression of either Ser or fng and the resulting wings have both dorsal and ventral cell fates. (Klein et al., 1998) Ser is not required for the initiation of wing development, but rather for the expansion and early patterning of the wing primordium. (Klein and Martinez Arias, 1998) Dl and Ser are redundant N signals required for asymmetric cell divisions within the sensory organ lineage. (Zeng et al., 1998) Genetic combinations with mutants of nub cause additive phenotypes. (Cifuentes and Garcia-Bellido, 1997) The combined effect of N and its target genes ct and wg regulate the expression of N ligands Dl and Ser which restrict N signalling to the wing dorsoventral boundary. (de Celis and Bray, 1997) Ser does not signal in the dorsal regions of the developing imaginal wing disc due to the action of the fng gene product. Ectopic expression studies reveal the regulation of Ser by fng occurs at the level of protein and not Ser transcription. (Fleming et al., 1997) Ser ligand binding to N is a necessary but insufficient step toward N activation. (Hukriede et al., 1997) Ser determines vg expression domains in the wing pouch. (Kim et al., 1997) The activities of Ser and Dl during wing development are studied. Ser can activate or inactivate N in a concentration-dependent manner. While inactivation is likely to be mediated by a dominant negative effect over N, the activation is similar to that elicited by Dl and requires the product of the Su(H) gene. Results indicate that regulation of the concentration of Ser during development must be an important way of regulating its activity. (Klein et al., 1997) wg is required indirectly for ct expression, results suggest this requirement is due to the regulation by wg of Dl and Ser expression in cells flanking the ct and wg expression domains. Dl and Ser play a dual role in the regulation of ct and wg expression. (Micchelli et al., 1997) Ser and Dl maintain each other's expression in the wing by a positive feedback loop. fng functions to position and restrict this feedback loop to the developing dorsal-ventral boundary. (Panin et al., 1997) The secreted forms of the Dl and Ser gene products are antagonists of N signalling in the developing eye and wing. (Sun and Artavanis-Tsakonas, 1997) Ser and Dl, two N ligands, have asymmetrical requirements at the dorsal-ventral boundary during wing development. (de Celis et al., 1996) N-expressing cells in a given compartment have different responses to Dl and Ser. Dl and Ser function as compartment-specific signals in the wing disc, to activate N and induce downstream genes required for wing formation. (Doherty et al., 1996) Dl and Ser have clearly distinct capabilities when ectopically expressed during wing development; Dl always acts as a strong activator of N and induces wing outgrowth and margin formation, Ser mediates activation of N only under certain circumstances and even acts as an inhibitor of N under other conditions. (Jonsson and Knust, 1996) Ser expression can e used to follow salivary duct development. (Kuo et al., 1996) Ser activity is not essential for proper eye development. Intracellularly truncated forms of Ser and Dl behave as dominant-negative proteins in an apparently non-cell autonomous manner. The presence of intracellular domains is essential for proper N ligand function in the eye. (Sun and Artavanis-Tsakonas, 1996) Induction of vg requires the combined activities of Ser, wg and N. Based on the patterns of expression and requirements for Ser and wg during initiation wing development it is proposed that Ser is a dorsal signal and that wg is a ventral signal. Their combination at the dorso-ventral interface activates the N receptor and leads to vg expression. (Couso et al., 1995) Localised expression of Ser in dorsal wing cells provides the signal to activate wg. (Diaz-Benjumea and Cohen, 1995) Ser can replace Dl gene function during embryonic neuroblast segregation and expression of Ser leads to N-dependent suppression of ac expression in proneural clusters. Results suggest that Ser functions as an alternative ligand capable of N activation. (Gu et al., 1995) Clonal analysis of Ser loss of function alleles suggests a non-autonomous role for the Ser product, consistent with its proposed function as a ligand for the N receptor. (Hukriede and Fleming, 1995) Compartmentalization of the wing disc, dorsal cell behaviour and the expression of two dorsally expressed putative signalling molecules, fng and Ser, are regulated by the ap selector gene. fng and Ser are distinct components of a single ap-regulated cell recognition and signal induction mechanism. Clonal analysis demonstrates that fng serves as a boundary-determining molecule such that Ser is induced wherever cells expressing fng and cells not expressing fng are juxtaposed. (Kim et al., 1995) vg is required for the proper pattern of expression of ap, sd and Ser. (Silber et al., 1995) The phenotypes of the Abruptex class of N allele are modified by mutations at Ser, Dl, H and gro. (de Celis and Garcia-Bellido, 1994) Wild type function of Ser is required for the control of position-specific cell proliferation during development of meso- and metathoracic dorsal discs, which in turn exerts a direct effect on morphogenesis. (Speicher et al., 1994) Mutations at Ser share phenotypes with mutations at sno, and genetic interactions indicate that sno, Ser and N function in common pathways. (Coyle-Thompson and Banerjee, 1993) A new allele of Notch, NM1, has been isolated that behaves genetically as both an antimorph and a loss of function allele: genetic interactions with Delta and Serrate alleles of the Beaded locus suggest that NM1 products have modified binding abilities with both Dl and Bd products. (de Celis et al., 1993) The dominant Ser mutation causes a gap in the posterior wing tip and margin and a portion of the blade. The phenotype of homozygous Ser flies ranges from deep incisions of the wing to gaps in the wing margin. Ser is a wing margin mutation that interacts synergistically with ct. Double mutants with ct46l and ct53d have extreme phenotypes and suffer tissue loss at the wing tip which is not seen in the single mutants. Ser has no effect on ctL32 mutants as they have already lost the wing tip tissue. (Jack and DeLotto, 1992) Analysis of mosaic females indicates that Ser, ea, snk and tub are expressed in the germline during oogenesis. (Stein et al., 1991) Phenotypic interactions of Ser alleles with the neurogenic mutations in N and Dl together with the structural similarity of the proteins encoded by the genes suggest close interactions at the protein level. (Thomas et al., 1991) Ser is an essential EGF-like protein. (Fleming et al., 1990) Mutant individuals display notched wing tips. (Duncan and Kaufman, 1975) "Maps to the right of ro: 2.1" was stated as revision. "Maps to the right of Pr: 1.5" was stated as revision. (Curry, 1939) Originally recovered alleles were recessive lethal with a dominant incised-wing phenotype; SerBd-1 was very weak and highly variable when first recovered, but gained expressivity with selection; subsequently isolated alleles were stronger. Wings reduced by marginal excision both anteriorly and posteriorly. Phenotype of SerBd-1/SerBd-1/+ extreme (Peter Lewis). Expression and interaction studied by Goldschmidt and Gardner (1942). Expression of SerBd-1, SerBd-3 and Ser1 suppressed by H (Bridges, 1938) and Ax alleles (Bang). In combination with several different Minutes, causes incomplete development of anal and genital imaginal discs in males and less frequently in females (Goldschmidt, 1948; Sturtevant, 1949). Ser1 (originally designated Ser: Serrate) homozygous viable; initially thought to be homozygous lethal, but lethality removable by recombination (Belt, 1971). The closely linked recessive lethal persists in many Ser1-bearing chromosomes. Recessive lethal alleles, which lack the dominant wing phenotype, recovered as revertants of Ser1 (symbolized "SerSrv") or selected on the basis of their failure to complement the lethality of SerBd-3 (symbolized Bdr). Allelism of SerBd-r1 (originally designated std: serratoid) inferred from enhanced wing incising in heterozygotes with Ser1 and genetic map position similar to that of Ser1; homozygous viability unknown. Cuticle preparations of embryos homozygous for Ser1 revertants reveal lack of germband retraction, improper deposition of cuticle, lack of head and thoracic structures, lack of Filzkorper and in severe cases, only a remaining patch of cuticle (either ventral or dorsal). Central-nervous-system defects revealed by anti-horseradish peroxidase preparations include breaks in the longitudinal and/or commissure nerve tracts, twisted or unretracted nerve tracts, only a single nerve tract and occasionally only the presence of groups of staining cells scattered throughout the embryo (Fleming et al., 1990). Each "SerSrv" allele displays the whole range of embryonic phenotypes but the proportions of individuals with a particular phenotype varies between alleles.
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079803 RefSeq (Proteins) • NP_524527 DDBJ / EMBL / GenBank • AAA28938 AAF56678 AAM75071 AX357041 AX417399 AY128478 AY863907 AY863908 AY863909 AY863910 AY863911 AY863912 AY863913 AY863914 AY863915 AY863916 AY863917 AY863918 AY863919 AY863920 AY863921 AY863922 AY863923 AY863924 AY863925 AY863926 AY863927 AY863928 BI356067 CAA40148 CAD23269 CAD35403 M35759 S77925 X56811 Entrez Gene - A searchable database of RefSeq genes. • 43275 UniProtKB/Swiss-Prot • P18168 UniProtKB/TrEMBL • Q8MQN5
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • EGF-like calcium-binding, conserved site (IPR018097) EGF-type aspartate/asparagine hydroxylation site (IPR000152) Epidermal growth factor-like domain (IPR000742) Delta/Serrate/lag-2 (DSL) protein (IPR001774) EGF-like calcium-binding (IPR001881) VWC out (IPR006552) Notch ligand, N-terminal (IPR011651) EGF-like, conserved site (IPR013032) Jagged/Serrate protein (IPR026219)
Linkouts
	BioGRID - A database of protein and genetic interactions • 68163 DroID - A comprehensive database of gene and protein interactions. • FBgn0004197 DRSC - Results from RNAi screens. • FBgn0004197 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004197 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6127-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0004197 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43275 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /neural/serrate.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43275 modMine - Data generated by the modENCODE project. • FBgn0004197 REDfly - A database of transcriptional regulatory elements. • FBgn0004197 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • P18168
Synonyms & Secondary IDs ( 15 )
Reported As
Symbol Synonym	Bd (Gottschewski, 1935, Goldschmidt, 1944, Curry, 1939, Jack and DeLotto, 1992, Mendanha et al., 2010) CG6127 (Keleman et al., 2009.8.5, Perkins et al., 2009, Ni et al., 2010.12.1) CT18858 (Hynes and Zhao, 2000) mel(3)8   Rpw (Soanes and Bell, 1995, ) Ser (Althauser et al., 2005, Singh et al., 2006, Childress et al., 2006, Ward et al., 2006, Gonzalez et al., 2006, Singh and Wook-Choi, 2007, Sato and Tomlinson, 2007, Mao et al., 2006, Herranz and Milan, 2006, Sato and Tomlinson, 2007, Mukherjee et al., 2006, Wang and Struhl, 2004, Monastirioti et al., 2010, Richter et al., 2011, Rauskolb and Irvine, 1999, Michellod et al., 2003, Trang et al., 2004, Gallet et al., 2006, Krzemień et al., 2007, Lei et al., 2003, Xie et al., 2012, Griffiths et al., 2007, Galindo et al., 2005, Lee and Lundell, 2007, Richardson and Pichaud, 2010, Sasaki et al., 2007, Fuwa et al., 2006, Okegbe and DiNardo, 2011, Thomas and van Meyel, 2007, Childress et al., 2006, Ayukawa et al., 2008, Singh et al., 2008, Miller and Herman, 2008, Fiuza et al., 2010, Langdon et al., 2006, Macdonald and Long, 2005, Xing et al., 2007, Minakhina et al., 2007, Barad et al., 2010, Jaekel and Klein, 2006, Vaccari et al., 2008, Ciechanska et al., 2007, Lee et al., 2009, Bhattacharya and Baker, 2009, Melicharek et al., 2008, Rafel and Milán, 2008, Pérez et al., 2005, Dworkin et al., 2009, Herranz et al., 2006, Schaaf et al., 2009, Flaherty et al., 2009, Buceta et al., 2007, Shi et al., 2006, Brodu et al., 2004, Ozdowski et al., 2009, Baonza and Freeman, 2005, Wang and Huang, 2009, Sanders et al., 2009, Martinez et al., 2009, Babaoglan et al., 2009, Gutierrez-Aviño et al., 2009, Becam et al., 2010, Saj et al., 2010, Wang et al., 2010, Flaherty et al., 2010, Herranz et al., 2006, Herz et al., 2010, Hamel et al., 2010, Kitadate and Kobayashi, 2010, Vachias et al., 2010, Nicholson et al., 2011, Beltran et al., 2007, Kim et al., 2010, Yamamoto et al., 2012, Cherbas et al., 2011, Grigorian et al., 2011, Poulton et al., 2011, Benhra et al., 2011, Park et al., 2011, Vallejo et al., 2011, Mukherjee et al., 2011, Formaz-Preston et al., 2012, Xie et al., 2012, Quijano et al., 2011, Cho et al., 2006, Leonardi et al., 2011, Tsubota et al., 2011, Zacharioudaki et al., 2012, Sagner et al., 2012) ser (Gallet and Therond, 2005, Chanut-Delalande et al., 2006, Gallet et al., 2006) SER (Xu et al., 2007) std
Name Synonym	Beaded (Hentges and Justice, 2004, ) dmSerrate (Lissemore and Starmer, 1999) Ripped wing   Serrate (Althauser et al., 2005, Singh et al., 2006, Parks et al., 2006, Sato and Tomlinson, 2007, Bernard et al., 2006, Polo and Di, 2006, Herranz and Milan, 2006, Li and Baker, 2004, Radtke et al., 2005, Greenberg and Hatini, 2007, Sato and Tomlinson, 2007, Vachias et al., 2007, Ohlstein and Spradling, 2007, Ohlstein and Spradling, 2007, Ward et al., 2006, Sasaki et al., 2007, Fuwa et al., 2006, Okegbe and DiNardo, 2011, Thomas and van Meyel, 2007, Glittenberg et al., 2006, Axelson, 2006, Ayukawa et al., 2008, Singh et al., 2008, Okegbe et al., 2008, Xie, 2008, Fiuza et al., 2010, Langdon et al., 2006, Xing et al., 2007, Minakhina et al., 2007, Grammont, 2007, Vaccari et al., 2008, Ciechanska et al., 2007, Rafel and Milán, 2008, Banyai and Patthy, 2004, Schaaf et al., 2009, Fontana and Posakony, 2009, Bhattacharya and Baker, 2009, Shi et al., 2006, Buceta et al., 2007, Sanders et al., 2009, Martinez et al., 2009, Gutierrez-Aviño et al., 2009, Baonza and Freeman, 2005, Becam et al., 2010, Saj et al., 2010, Levine et al., 2010, Hamel et al., 2010, Weinmaster, 1997, Kitadate and Kobayashi, 2010, Vachias et al., 2010, Jung et al., 2010, Nicholson et al., 2011, Yamamoto et al., 2012, Kim et al., 2010, Cherbas et al., 2011, Grigorian et al., 2011, Poulton et al., 2011, Dalton et al., 2011, Benhra et al., 2011, Herz et al., 2010, Formaz-Preston et al., 2012, Sagner et al., 2012) serrate (Delon and Payre, 2004, Holley, 2006, Jacques et al., 2009, Marcu et al., 2011) serratoid
Secondary FlyBase IDs
	FBgn0003111 FBgn0003355
References ( 540 )
Generate a list of	All references relating to this gene ( 540 )
List References by type	Research paper  ( 300 ) Supplementary material  ( 10 ) Review  ( 120 ) Personal communication to FlyBase  ( 16 ) Abstract  ( 78 ) FlyBase analysis  ( 1 ) Patent  ( 2 ) Protein sequence record  ( 1 ) Book  ( 3 ) Conference report  ( 3 ) Note  ( 1 ) Curated genome annotation  ( 2 ) DNA/RNA sequence record  ( 2 )
Recent research papers ( 25 )
	Pitsouli and Perrimon, 2013, Sci. Signal. 6(263): ra12 The homeobox transcription factor cut coordinates patterning and growth during Drosophila airway remodeling. [FBrf0220848] Formaz-Preston et al., 2012, Dev. Biol. 369(2): 319--329 The Tbx20 homolog Midline represses wingless in conjunction with Groucho during the maintenance of segment polarity. [FBrf0219199] Gildor et al., 2012, Development 139(21): 4040--4050 Bidirectional Notch activation represses fusion competence in swarming adult Drosophila myoblasts. [FBrf0219658] Liu et al., 2012, Mol. Cell. Biol. 32(24): 4933--4945 Functional analysis of the NHR2 domain indicates that oligomerization of Neuralized regulates ubiquitination and endocytosis of Delta during Notch signaling. [FBrf0220817] Sagner et al., 2012, Curr. Biol. 22(14): 1296--1301 Establishment of Global Patterns of Planar Polarity during Growth of the Drosophila Wing Epithelium. [FBrf0219045] Xie et al., 2012, Dev. Biol. 363(2): 399--412 Drosophila Epsin's role in Notch ligand cells requires three Epsin protein functions: The lipid binding function of the ENTH domain, a single Ubiquitin interaction motif, and a subset of the C-terminal protein binding modules. [FBrf0217494] Xie et al., 2012, PLoS ONE 7(4): e36362 Uif, a Large Transmembrane Protein with EGF-Like Repeats, Can Antagonize Notch Signaling in Drosophila. [FBrf0218242] Yamamoto et al., 2012, Science 338(6111): 1229--1232 A Mutation in EGF Repeat-8 of Notch Discriminates Between Serrate/Jagged and Delta Family Ligands. [FBrf0220110] Zacharioudaki et al., 2012, Development 139(7): 1258--1269 bHLH-O proteins are crucial for Drosophila neuroblast self-renewal and mediate Notch-induced overproliferation. [FBrf0217605] Benhra et al., 2011, Curr. Biol. 21(1): 87--95 AP-1 Controls the Trafficking of Notch and Sanpodo toward E-Cadherin Junctions in Sensory Organ Precursors. [FBrf0212697] Cherbas et al., 2011, Genome Res. 21(2): 301--314 The transcriptional diversity of 25 Drosophila cell lines. [FBrf0213077] Dalton et al., 2011, Cell Death Differ. 18(7): 1150--1160 Drosophila Ndfip is a novel regulator of Notch signaling. [FBrf0214123] Grigorian et al., 2011, Dev. Biol. 353(1): 105--118 The convergence of Notch and MAPK signaling specifies the blood progenitor fate in the Drosophila mesoderm. [FBrf0213410] Hori et al., 2011, J. Cell Biol. 195(6): 1005--1015 Synergy between the ESCRT-III complex and Deltex defines a ligand-independent Notch signal. [FBrf0216916] Leonardi et al., 2011, Development 138(16): 3569--3578 Multiple O-glucosylation sites on Notch function as a buffer against temperature-dependent loss of signaling. [FBrf0214548] Marcu et al., 2011, PLoS ONE 6(1): e15361 Innate Immune Responses of Drosophila melanogaster Are Altered by Spaceflight. [FBrf0212851] Mukherjee et al., 2011, Science 332(6034): 1210--1213 Interaction between Notch and Hif-alpha in development and survival of Drosophila blood cells. [FBrf0214249] Nicholson et al., 2011, Development 138(2): 251--260 Notch-dependent expression of the archipelago ubiquitin ligase subunit in the Drosophila eye. [FBrf0212669] Okegbe and DiNardo, 2011, Development 138(7): 1259--1267 The endoderm specifies the mesodermal niche for the germline in Drosophila via Delta-Notch signaling. [FBrf0213233] Park et al., 2011, PLoS Genet. 7(8): e1002241 Specification of Drosophila corpora cardiaca neuroendocrine cells from mesoderm is regulated by Notch signaling. [FBrf0215231] Poulton et al., 2011, Development 138(9): 1737--1745 The microRNA pathway regulates the temporal pattern of Notch signaling in Drosophila follicle cells. [FBrf0213494] Quijano et al., 2011, Genetics 189(3): 809--824 Wg Signaling via Zw3 and Mad Restricts Self-Renewal of Sensory Organ Precursor Cells in Drosophila. [FBrf0216675] Richter et al., 2011, Nat. Cell Biol. 13(9): 1029--1039 The tumour suppressor L(3)mbt inhibits neuroepithelial proliferation and acts on insulator elements. [FBrf0215050] Tsubota et al., 2011, Fly 5(4): 275--284 Interactions between enhancer of rudimentary and Notch and deltex reveal a regulatory function of enhancer of rudimentary in the Notch signaling pathway in Drosophila melanogaster. [FBrf0217950] Vallejo et al., 2011, EMBO J. 30(4): 756--769 Targeting Notch signalling by the conserved miR-8/200 microRNA family in development and cancer cells. [FBrf0213063] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...