hrp36, P11, hnRNPA1, hnRNPA2, Hrb87Fa
Gene model reviewed during 5.43
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.47
One of a couple of protein products.
hnRNP-specific mAbs were obtained and used to purify hnRNP complexes from S2 cells. hnRNP proteins were identified on the basis of nucleoplasmic localization, association with nascent transcripts, crosslinking to poly(A)-containing RNA in living cells, and amino acid sequence. Staining of polytene chromosomes reveals that Hrb87F protein is associated with actively transcribing loci.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Hrb87F using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Hrb87F in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Loss of Hrb87F slows development, with a significant reduction in adult life span, decreased female fecundity and high sensitivity to starvation and thermal stresses.
The consequences of HRB overexpression and absence in living flies is examined. Overexpression of Hrb87F does alter the splicing of Ddc pre-mRNA, indicating the overexpressed protein can reproduce the in vitro effect of excess protein.
The distribution of the hnRNP protein Hrb87F on nascent transcripts from polytene chromosomes has been studied.
412 element inserted in 3' UTR in some Canton S lines
Homology to the mammalian A and B hnRNP proteins based on amino acid sequence inferred from nucleotide sequence.